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"bytes": 16586 + }, + "src/final_comutation/publish.py": { + "sha256": "c9b1732abd8063473660c610b27d5d991c58bdbf62f641a08cf6236b1034dff6", + "bytes": 9363 + }, + "src/final_comutation/therapy.py": { + "sha256": "ba484ab077850cb00c04f6d9efb3a977da076e89694b813d4b7c2b906c79fb6c", + "bytes": 95111 + } + }, + "no_prior_results_used": true, + "raw_data_redistributed": false +} \ No newline at end of file diff --git a/README.md b/README.md new file mode 100644 index 0000000000000000000000000000000000000000..7d96e201875c5cf6f407bc6af5de57fc51e3666c --- /dev/null +++ b/README.md @@ -0,0 +1,41 @@ +--- +pretty_name: Final Directional Co-Mutation Dependency Atlas +language: +- en +tags: +- cancer-genomics +- depmap +- crispr +- mutation +- drug-response +- reproducible-research +--- +# Final Directional Co-Mutation Dependency Atlas + +**Standalone fresh computation**: every statistical result was recomputed from official raw DepMap 24Q4 Public v1, PRISM 19Q4 v4, Reactome and optional cited sources. No outputs, C1 shortlist, or checkpoints from historical projects were loaded. + +The source code is under `src/final_comutation/`; experiment-section figures and tables are under `results/Paper_Experiment_Section/`. Computation status and limitations are under `results/Audit/`. + +## Findings for this particular run (dynamic) + +- C1 conservative discoveries: 83 +- Selected across-context results: 546 +- Drug inference: {"causal_mechanism_established": false, "interpretation": "Conditional drug response support differs from A-by-B nonadditive interaction or clinical therapeutic effect", "n_AB_vs_Bonly_BH": 0, "n_AB_vs_Bonly_tested": 50, "n_PRISM_BH_concordant": 8, "n_PRISM_BY_concordant": 5, "n_PRISM_conditional_tested": 49, "n_annotated_drug_hypotheses": 62, "n_external_independently_validated": 0, "n_fresh_C1": 83, "n_strict_AxB_BH": 0, "n_strict_interactions_tested": 31, "raw_data_only_no_prior_results": true, "study": "FRESH raw-source drug-response followup"} + +## Data provenance and scope + +Input providers: DepMap 24Q4 v1 (versioned figshare 27993248 v1), PRISM Repurposing 19Q4 v4 (figshare 9393293 v4), pinned Reactome 98, optionally Enrichr/MSigDB oncogenic signatures, cBioPortal selected TCGA cancer studies, and optional identified GDSC2. The raw input matrices and per-cell data are **not redistributed** here; the original providers should be cited and their terms reviewed. + +### Interpretation safeguards + +- CRISPR and drug-response contrasts are observational; co-mutation states do not establish causal order or genetic synergy. +- A=mutated and B=additionally mutated versus A-only is the primary estimand. A×B and B-only contrasts are auxiliary. +- Multiplicity-adjusted associations are computational, not independent cohort or wet-lab validation. +- `No reported qualifying mutation` is **not** verified wild type. +- TCGA prevalence is not patient treatment response. +- Failed/underpowered and unavailable validation evidence is retained explicitly. +- Authors must inspect all exported evidence and methods before manuscript submission. + +## Reproducibility + +Run the provided multi-cell Kaggle notebook or `python -m final_comutation.pipeline`. Source code and source manifests are preserved; see `results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Section_Claim_Evidence_Methods.md`. diff --git a/results/Audit/Execution_Stages.json b/results/Audit/Execution_Stages.json new file mode 100644 index 0000000000000000000000000000000000000000..4a26a9c988733b3d446b89b773fd780ab3a29337 --- /dev/null +++ b/results/Audit/Execution_Stages.json @@ -0,0 +1,100 @@ +[ + { + "notebook_has_no_prior_result_input": true, + "source_release": "DepMap 24Q4 v1", + "stage": "protocol", + "status": "FROZEN", + "timestamp_utc": "2026-11-04T19:26:36.149401+00:00" + }, + { + "n_provider_md5_checked": 7, + "n_source_files": 7, + "stage": "raw_providers", + "status": "VERIFIED", + "timestamp_utc": "2026-11-04T19:29:16.525662+00:00" + }, + { + "n_genes": 16568, + "n_models": 1178, + "stage": "cohort_integration", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T19:29:36.228907+00:00" + }, + { + "n_all": 274482056, + "n_eligible": 14302, + "stage": "all_pairs_feasibility", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T19:39:48.165182+00:00" + }, + { + "n_contexts": 16920, + "n_tests_completed": 2751, + "stage": "genomewide_gene_fits", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T20:11:09.869839+00:00" + }, + { + "n_primary_by": 83, + "n_total_selected": 546, + "stage": "primary_c1", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T20:43:10.119931+00:00" + }, + { + "n_nomination_rows": 546, + "n_refits": 12975, + "stage": "internal_c2", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T20:43:49.556883+00:00" + }, + { + "n_rows": 546, + "stage": "holdout", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T20:43:59.433360+00:00" + }, + { + "n_GSEA": 309882, + "n_ORA": 51083, + "stage": "reactome", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T22:11:05.143661+00:00" + }, + { + "n_records": 1092, + "stage": "omics", + "status": "COMPLETE_OR_UNAVAILABLE_PER_ASSAY", + "timestamp_utc": "2026-11-04T22:11:39.397883+00:00" + }, + { + "C3_tested": 280, + "n_hypotheses": 546, + "stage": "biological_annotation", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T22:12:28.998466+00:00" + }, + { + "n_C1": 83, + "n_conditional": 49, + "stage": "therapeutic", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T22:15:24.417618+00:00" + }, + { + "stage": "functional_annotations", + "status": "ATTEMPTED", + "timestamp_utc": "2026-11-04T22:16:04.803165+00:00" + }, + { + "n_files": 36, + "stage": "paper_outputs", + "status": "COMPLETE", + "timestamp_utc": "2026-11-04T22:16:12.913933+00:00" + }, + { + "stage": "final_acceptance", + "status": "PASS", + "timestamp_utc": "2026-11-04T22:16:12.917783+00:00" + } +] \ No newline at end of file diff --git a/results/Audit/Integrity_Checks.json b/results/Audit/Integrity_Checks.json new file mode 100644 index 0000000000000000000000000000000000000000..99a7834c9962ba1ef46af089ec68cee78c09d8ee --- /dev/null +++ b/results/Audit/Integrity_Checks.json @@ -0,0 +1,13 @@ +{ + "AxB_global_BY_ge_BH": true, + "Bonly_global_BY_ge_BH": true, + "C1_global_BY_le_005": true, + "C1_negative_effect": true, + "C1_one_row_per_key": true, + "C1_source_is_from_this_run": true, + "C1_subset_of_selected": true, + "PRISM_global_BY_ge_BH": true, + "all_gene_test_results_have_multiple_testing_metadata": true, + "main_context_estimable_n": 2751, + "same_drug_hypothesis_keys_across_models": true +} \ No newline at end of file diff --git a/results/Audit/Run_Complete.json b/results/Audit/Run_Complete.json new file mode 100644 index 0000000000000000000000000000000000000000..100ebcd7fd0a052969d71c7827d02b7887750f5f --- /dev/null +++ b/results/Audit/Run_Complete.json @@ -0,0 +1,32 @@ +{ + "claim_levels": { + "four_group_interaction": "auxiliary", + "independent_validation": "not_achieved_without_verifiable_external_cohort", + "main_C1": "observational", + "therapeutic": "observational" + }, + "completion_utc": "2026-11-04T22:16:12.916243+00:00", + "main_C1_count": 83, + "main_selected_all_contexts": 546, + "output_root": "/kaggle/working/final_comutation_fresh_20261104_192636_UTC", + "raw_source_policy": "ONLY_OFFICIAL_UPSTREAM_DATA; NO_HISTORICAL_RESULTS", + "research_status": "RAW_DATA_COMPUTATIONAL_RUN_COMPLETE", + "researcher_review": "PENDING", + "run_seconds": 10176.768191217001, + "therapeutic": { + "causal_mechanism_established": false, + "interpretation": "Conditional drug response support differs from A-by-B nonadditive interaction or clinical therapeutic effect", + "n_AB_vs_Bonly_BH": 0, + "n_AB_vs_Bonly_tested": 50, + "n_PRISM_BH_concordant": 8, + "n_PRISM_BY_concordant": 5, + "n_PRISM_conditional_tested": 49, + "n_annotated_drug_hypotheses": 62, + "n_external_independently_validated": 0, + "n_fresh_C1": 83, + "n_strict_AxB_BH": 0, + "n_strict_interactions_tested": 31, + "raw_data_only_no_prior_results": true, + "study": "FRESH raw-source drug-response followup" + } +} \ No newline at end of file diff --git a/results/Audit/Runtime_Environment.json b/results/Audit/Runtime_Environment.json new file mode 100644 index 0000000000000000000000000000000000000000..eb785d9c36d8e68c7ca9340b0aa370febe6026b3 --- /dev/null +++ b/results/Audit/Runtime_Environment.json @@ -0,0 +1,17 @@ +{ + "cpu_count": 4, + "gpu_use": "NOT_REQUIRED_BY_STATISTICAL_PIPELINE", + "packages": { + "huggingface_hub": "1.33.0", + "matplotlib": "3.10.0", + "numpy": "2.1.3", + "pandas": "2.3.3", + "python": "3.13.18", + "requests": "2.34.2", + "scipy": "1.16.3", + "statsmodels": "0.15.0" + }, + "pipeline_module": "final_comutation.pipeline", + "platform": "Linux-6.18.55+-x86_64-with-glibc2.39", + "raw_result_policy": "No prior result URLs, checkpoint restores, or legacy shortlist inputs" +} \ No newline at end of file diff --git a/results/Functional_Annotations/Optional_Annotation_Errors.csv b/results/Functional_Annotations/Optional_Annotation_Errors.csv new file mode 100644 index 0000000000000000000000000000000000000000..8b137891791fe96927ad78e64b0aad7bded08bdc --- /dev/null +++ b/results/Functional_Annotations/Optional_Annotation_Errors.csv @@ -0,0 +1 @@ + diff --git a/results/Functional_Annotations/STRING_Protein_Association_Network.csv b/results/Functional_Annotations/STRING_Protein_Association_Network.csv new file mode 100644 index 0000000000000000000000000000000000000000..6d028aa449b3dcb4509d004bd34e45c61d4b5a2f --- /dev/null +++ b/results/Functional_Annotations/STRING_Protein_Association_Network.csv @@ -0,0 +1,25 @@ +stringId_A,stringId_B,preferredName_A,preferredName_B,ncbiTaxonId,score,nscore,fscore,pscore,ascore,escore,dscore,tscore,evidence_type +9606.ENSP00000256078,9606.ENSP00000269305,KRAS,TP53,9606,0.954,0,0,0.0,0.0,0.119,0.0,0.95,STRING_FUNCTIONAL_ASSOCIATION_NOT_DIRECT_CAUSAL_INTERACTION +9606.ENSP00000256078,9606.ENSP00000263967,KRAS,PIK3CA,9606,0.999,0,0,0.0,0.122,0.969,0.9,0.929,STRING_FUNCTIONAL_ASSOCIATION_NOT_DIRECT_CAUSAL_INTERACTION 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"https://rest.uniprot.org/uniprotkb/search", + "STRING": "https://string-db.org/api/tsv/network", + "n_genes_requested": 79, + "n_reviewed_annotated": 79, + "string_status": "REQUEST_COMPLETED", + "annotation_is_not_perturbation_or_validation": true +} \ No newline at end of file diff --git a/results/Functional_Annotations/UniProt_GO_Gene_Function.csv b/results/Functional_Annotations/UniProt_GO_Gene_Function.csv new file mode 100644 index 0000000000000000000000000000000000000000..528ba2c5d1347b75747ff5f27bd736b1a5a68c83 --- /dev/null +++ b/results/Functional_Annotations/UniProt_GO_Gene_Function.csv @@ -0,0 +1,80 @@ +Gene,Status,Accession,ProteinName,FunctionSummary,GO_BP,GO_MF,GO_CC +ABTB2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8N961,Ankyrin repeat and BTB/POZ domain-containing protein 2,May be involved in the initiation of hepatocyte growth,,F:protein heterodimerization activity,C:nucleoplasm +ACBD6,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9BR61,Acyl-CoA-binding domain-containing protein 6,"Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. Plays a role in protein N-myristoylation (PubMed:37951597)",,F:enzyme activator activity | F:fatty-acyl-CoA binding | F:lipid binding,C:cytoplasm | C:cytosol | C:endoplasmic reticulum | C:nucleus | C:plasma membrane +AGRP,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O00253,Agouti-related protein,"Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland (PubMed:10371151, PubMed:11145747, PubMed:9311920, PubMed:9892020). Involved in the control of feeding behavior via the central melanocortin system (PubMed:15927146, PubMed:9311920). Has very low activity towards MC5R (PubMed:9311920, PubMed:9892020). Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism (PubMed:17041250)",P:adult feeding behavior | P:circadian rhythm | P:eating behavior | P:hormone-mediated signaling pathway | P:long-day photoperiodism | P:maternal process involved in female pregnancy | P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway | P:neuropeptide signaling pathway | P:positive regulation of appetite | P:positive regulation of feeding behavior | P:regulation of appetite | P:regulation of feeding behavior | P:response to insulin,F:neuropeptide hormone activity | F:receptor antagonist activity | F:signaling receptor binding | F:type 1 melanocortin receptor binding,C:extracellular region | C:Golgi lumen | C:neuronal cell body +ASIC3,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9UHC3,Acid-sensing ion channel 3,"Forms pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system (PubMed:10842183, PubMed:11587714, PubMed:9744806, PubMed:9886053). Upon extracellular acidification, these channels generate a biphasic current with a fast inactivating and a slow sustained phase (PubMed:10842183, PubMed:9744806, PubMed:9886053). ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (By similarity). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:9744806, PubMed:9886053). As a neuronal acid sensor, probably contributes to mechanoreception, acid noci",P:detection of chemical stimulus involved in sensory perception of pain | P:membrane depolarization | P:sensory perception of sour taste | P:sodium ion transmembrane transport,F:pH-gated monoatomic ion channel activity | F:pH-gated sodium channel activity | F:sodium channel activity,C:cytoplasm | C:plasma membrane +B3GALNT1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O75752,"UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1",Transfers N-acetylgalactosamine onto globotriaosylceramide (PubMed:10993897). Plays a critical role in preimplantation stage embryonic development (By similarity),P:glycoprotein biosynthetic process | P:glycosphingolipid biosynthetic process | P:oligosaccharide biosynthetic process,"F:galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity | F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity",C:Golgi membrane +BORCS6,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q96GS4,BLOC-1-related complex subunit 6,"As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor",P:lysosome localization | P:organelle transport along microtubule | P:regulation of endosome size | P:regulation of lysosome size,F:identical protein binding,C:BORC complex | C:cytoplasmic side of lysosomal membrane +BRAF,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P15056,Serine/threonine-protein kinase B-raf,"Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)",P:animal organ morphogenesis | P:cellular response to calcium ion | P:epidermal growth factor receptor signaling pathway | P:establishment of protein localization to membrane | P:MAPK cascade | P:negative regulation of apoptotic process | P:positive regulation of D-glucose transmembrane transport | P:positive regulation of ERK1 and ERK2 cascade | P:positive regulation of gene expression | P:positive regulation of peptidyl-serine phosphorylation | P:protein phosphorylation,F:ATP binding | F:calcium ion binding | F:identical protein binding | F:MAP kinase kinase activity | F:MAP kinase kinase kinase activity | F:protein kinase activity | F:protein serine kinase activity | F:protein serine/threonine kinase activity | F:scaffold protein binding,C:cytoplasm | C:cytosol | C:mitochondrion | C:nucleus | C:plasma membrane +CCL3L3,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P16619,C-C motif chemokine 3-like 1,"Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5",P:antimicrobial humoral immune response mediated by antimicrobial peptide | P:cell chemotaxis | P:chemokine-mediated signaling pathway | P:inflammatory response | P:negative regulation of cell population proliferation | P:positive regulation of cell migration,F:CCR chemokine receptor binding | F:chemokine activity,C:extracellular region +CD79A,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P11912,B-cell antigen receptor complex-associated protein alpha chain,"Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells",P:B cell activation | P:B cell differentiation | P:B cell proliferation | P:B cell receptor signaling pathway,F:identical protein binding | F:transmembrane signaling receptor activity,C:B cell receptor complex | C:external side of plasma membrane | C:IgM B cell receptor complex | C:membrane raft | C:multivesicular body | C:plasma membrane +CDK19,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9BWU1,Cyclin-dependent kinase 19,"Component of the Mediator complex, a transcriptional coactivator required for regulated expression of nearly all RNA polymerase II-dependent genes. Acts as a molecular bridge between gene-specific regulatory proteins and the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters through direct interactions with transcriptional regulators and serves as a scaffold for assembly of the pre-initiation complex with RNA polymerase II and general transcription factors. Contributes to phosphorylation of transcription factors and other substrates, including RNA polymerase II and the Notch1 intracellular domain (ICN1), thereby modulating gene expression programs (PubMed:253",P:cellular response to lipopolysaccharide | P:positive regulation of apoptotic process | P:regulation of transcription by RNA polymerase II,F:ATP binding | F:cyclin-dependent protein serine/threonine kinase activity | F:protein serine kinase activity | F:protein serine/threonine kinase activity,C:CKM complex | C:cytoplasm | C:cytosol | C:nucleoplasm | C:nucleus | C:perinuclear region of cytoplasm +CDKN1A,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P38936,Cyclin-dependent kinase inhibitor 1,"Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin","P:cellular response to amino acid starvation | P:cellular response to cell-matrix adhesion | P:cellular response to ionizing radiation | P:cellular response to UV-B | P:cellular senescence | P:DNA damage response | P:DNA damage response, signal transduction by p53 class mediator | P:G1/S transition of mitotic cell cycle | P:heart development | P:import into nucleus | P:intrinsic apoptotic signaling pathway | P:mitotic G1 DNA damage checkpoint signaling | P:mitotic G2 DNA damage checkpoint signaling | P:negative regulation of cardiac muscle tissue regeneration | P:negative regulation of cell growth | P:negative regulation of cell population proliferation | P:negative regulation of DNA biosynt",F:cyclin binding | F:cyclin-dependent protein serine/threonine kinase inhibitor activity | F:molecular function activator activity | F:molecular function inhibitor activity | F:protein kinase binding | F:protein kinase inhibitor activity | F:protein sequestering activity | F:protein serine/threonine kinase binding | F:protein-containing complex binding | F:ubiquitin protein ligase binding,C:cyclin-dependent protein kinase holoenzyme complex | C:cytoplasm | C:cytosol | C:nuclear body | C:nucleolus | C:nucleoplasm | C:nucleus | C:PCNA-p21 complex | C:protein-containing complex +CHURC1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8WUH1,Protein Churchill,Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity) | Does not bind DNA by itself,P:fibroblast growth factor receptor signaling pathway | P:positive regulation of DNA-templated transcription,F:zinc ion binding, +CNBP,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P62633,CCHC-type zinc finger nucleic acid binding protein,"Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity) | Binds G-rich elements in target mRNA coding sequences (PubMed:28329689). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (PubMed:28329689) | Binds to RNA | Binds to RNA | Binds to RNA | Binds to RNA | Binds to RNA",P:cholesterol homeostasis | P:G-quadruplex DNA formation | P:negative regulation of transcription by RNA polymerase II | P:positive regulation of cell population proliferation | P:positive regulation of cytoplasmic translation | P:positive regulation of DNA-templated transcription | P:positive regulation of transcription by RNA polymerase II | P:regulation of DNA-templated transcription,F:G-quadruplex DNA binding | F:mRNA binding | F:RNA binding | F:single-stranded RNA binding | F:translation regulator activity | F:zinc ion binding,C:cytoplasm | C:cytosol | C:endoplasmic reticulum | C:nucleus +CNOT4,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O95628,CCR4-NOT transcription complex subunit 4,"Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391)",P:deadenylation-independent decapping of nuclear-transcribed mRNA | P:nuclear-transcribed mRNA poly(A) tail shortening | P:protein autoubiquitination | P:regulation of megakaryocyte differentiation | P:ubiquitin-dependent protein catabolic process,F:metal ion binding | F:RNA binding | F:ubiquitin protein ligase activity | F:ubiquitin-protein transferase activity,C:CCR4-NOT complex | C:cytosol | C:nucleus +CPEB1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9BZB8,Cytoplasmic polyadenylation element-binding protein 1,"Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE",P:cellular response to amino acid stimulus | P:cellular response to hypoxia | P:cellular response to insulin stimulus | P:negative regulation of cytoplasmic translation | P:regulation of mRNA 3'-end processing,"F:mRNA 3'-UTR AU-rich region binding | F:mRNA 3'-UTR binding | F:mRNA regulatory element binding translation repressor activity | F:ribosome binding | F:translation factor activity, RNA binding",C:cytoplasm | C:cytosol | C:dendrite | C:membrane | C:neuron projection | C:nucleoplasm | C:nucleus | C:P-body | C:postsynaptic density | C:synapse +CRYL1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9Y2S2,Lambda-crystallin homolog,"Catalyzes the conversion of L-gulonate to 3-dehydro-L-gulonate (PubMed:15809331, PubMed:40737316). It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate (PubMed:15809331). Utilizes NAD as the sole cosubstrate and shows no activity with NADP (PubMed:40737316)",P:fatty acid metabolic process,F:L-gulonate 3-dehydrogenase activity | F:NAD+ binding | F:protein homodimerization activity,C:cytoplasm | C:cytosol | C:extracellular exosome +DHFR,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P00374,Dihydrofolate reductase,"Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner (PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595). Key enzyme in folate metabolism. Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway (PubMed:21876188, PubMed:22235121). Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2",P:'de novo' pyrimidine nucleobase biosynthetic process | P:axon regeneration | P:dihydrofolate metabolic process | P:DNA replication | P:folic acid metabolic process | P:negative regulation of translation | P:regulation of removal of superoxide radicals | P:tetrahydrobiopterin biosynthetic process | P:tetrahydrofolate biosynthetic process | P:tetrahydrofolate metabolic process,F:dihydrofolate reductase activity | F:folic acid binding | F:mRNA binding | F:mRNA regulatory element binding translation repressor activity | F:NADP binding | F:NADPH binding | F:sequence-specific mRNA binding,C:cytoplasm | C:cytosol | C:mitochondrion | C:nucleus | C:replication fork +DOK1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q99704,Docking protein 1,DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3,P:cell surface receptor protein tyrosine kinase signaling pathway | P:cell surface receptor signaling pathway | P:Ras protein signal transduction | P:signal transduction,F:signaling adaptor activity,C:cytosol | C:nucleus | C:perinuclear region of cytoplasm +DUSP1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P28562,Dual specificity protein phosphatase 1,"Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle",P:cellular response to chemokine | P:cellular response to hormone stimulus | P:endoderm formation | P:intracellular signal transduction | P:negative regulation of apoptotic process | P:negative regulation of cell adhesion | P:negative regulation of cell population proliferation | P:negative regulation of DNA biosynthetic process | P:negative regulation of ERK1 and ERK2 cascade | P:negative regulation of MAPK cascade | P:negative regulation of meiotic cell cycle | P:negative regulation of monocyte chemotaxis | P:negative regulation of p38MAPK cascade | P:peptidyl-serine dephosphorylation | P:peptidyl-threonine dephosphorylation | P:positive regulation of apoptotic process | P:regulation of mi,F:growth factor binding | F:MAP kinase tyrosine/serine/threonine phosphatase activity | F:mitogen-activated protein kinase binding | F:phosphoprotein phosphatase activity | F:protein serine/threonine phosphatase activity | F:protein tyrosine phosphatase activity | F:protein tyrosine/serine/threonine phosphatase activity,C:cytoplasm | C:nucleus +E2F3,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O00716,Transcription factor E2F3,"Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity)",P:G1/S transition of mitotic cell cycle | P:negative regulation of fat cell proliferation | P:positive regulation of transcription by RNA polymerase II | P:positive regulation of vascular associated smooth muscle cell apoptotic process | P:protein import into nucleus | P:regulation of transcription by RNA polymerase II | P:transcription initiation at RNA polymerase II promoter,"F:cis-regulatory region sequence-specific DNA binding | F:DNA-binding transcription activator activity, RNA polymerase II-specific | F:DNA-binding transcription factor activity | F:DNA-binding transcription factor activity, RNA polymerase II-specific | F:protein dimerization activity | F:RNA polymerase II cis-regulatory region sequence-specific DNA binding | F:sequence-specific DNA binding | F:sequence-specific double-stranded DNA binding",C:chromatin | C:nucleoplasm | C:nucleus | C:RNA polymerase II transcription regulator complex +ESCO1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q5FWF5,N-acetyltransferase ESCO1,"Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053)",P:mitotic sister chromatid cohesion | P:peptidyl-lysine acetylation | P:post-translational protein acetylation | P:regulation of DNA replication | P:sister chromatid cohesion,F:acetyltransferase activity | F:identical protein binding | F:N-acetyltransferase activity | F:protein-lysine-acetyltransferase activity | F:zinc ion binding,C:chromatin | C:chromosome | C:nucleoplasm | C:nucleus +FBXO28,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9NVF7,F-box only protein 28,"Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, promoting ubiquitination and proteasomal degradation of specific target proteins including TOP2A, RAB27A or itself (PubMed:27754753, PubMed:31678254). Regulates topoisomerase IIalpha/TOP2A decatenation activity and plays an important role in maintaining genomic stability (PubMed:27754753). Plays a role in lipid metabolism and inflammation through the ubiquitinated degradation of RAB27A (By similarity). Strongly regulates beta-cell survival without having any significant independent effect on insulin secretion (PubMed:29587369). Plays an essential role in spindle morphology and actin-based s",P:proteasome-mediated ubiquitin-dependent protein catabolic process | P:protein polyubiquitination | P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,F:identical protein binding | F:ubiquitin-like ligase-substrate adaptor activity,C:chromosome | C:cytoplasm | C:kinetochore | C:nucleoplasm | C:nucleus | C:SCF ubiquitin ligase complex +FEN1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P39748,Flap endonuclease 1,"Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also ","P:base-excision repair, gap-filling | P:DNA recombination | P:DNA repair | P:DNA replication | P:DNA replication, removal of RNA primer | P:double-strand break repair | P:double-strand break repair via homologous recombination | P:memory | P:positive regulation of sister chromatid cohesion | P:telomere maintenance via semi-conservative replication | P:UV protection",F:5'-3' exonuclease activity | F:5'-flap endonuclease activity | F:damaged DNA binding | F:DNA binding | F:double-stranded DNA binding | F:double-stranded DNA exodeoxyribonuclease activity | F:endonuclease activity | F:exonuclease activity | F:flap endonuclease activity | F:magnesium ion binding | F:manganese ion binding | F:RNA-DNA hybrid ribonuclease activity,"C:chromosome, telomeric region | C:membrane | C:mitochondrion | C:nucleolus | C:nucleoplasm | C:nucleus | C:protein-containing complex" +FOXL2NB,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q6ZUU3,FOXL2 neighbor protein,,,,C:fibrillar center +FZD9,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O00144,Frizzled-9,"Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal deve",P:bone regeneration | P:canonical Wnt signaling pathway | P:negative regulation of mitochondrial depolarization | P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | P:negative regulation of necroptotic process | P:negative regulation of neuron apoptotic process | P:negative regulation of skeletal muscle acetylcholine-gated channel clustering | P:nervous system development | P:non-canonical Wnt signaling pathway | P:ossification | P:positive regulation of apoptotic process | P:positive regulation of bone mineralization | P:positive regulation of canonical Wnt signaling pathway | P:positive regulation of neural precursor cell prolif,F:protein heterodimerization activity | F:protein homodimerization activity | F:Wnt receptor activity | F:Wnt-protein binding,C:cell surface | C:cytoplasm | C:endoplasmic reticulum membrane | C:extracellular region | C:Golgi apparatus | C:membrane | C:mitochondrial membrane | C:plasma membrane +GGT6,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q6P531,Glutathione hydrolase 6,Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors,P:glutathione metabolic process | P:leukotriene D4 biosynthetic process,F:glutathione gamma-glutamate hydrolase,C:extracellular exosome | C:membrane +GPRC5B,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9NZH0,G protein-coupled receptor family C group 5 member B,G protein-coupled receptor involved in the regulation of cell volume,P:cell volume homeostasis | P:intracellular signal transduction,F:G protein-coupled receptor activity | F:G protein-coupled receptor binding | F:protein kinase activator activity | F:protein kinase binding | F:protein tyrosine kinase binding,C:cell surface | C:cytoplasmic vesicle membrane | C:extracellular exosome | C:extracellular region | C:membrane raft | C:plasma membrane | C:signaling receptor complex +GPRC5C,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9NQ84,G protein-coupled receptor family C group 5 member C,This retinoic acid-inducible G protein-coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways,P:G protein-coupled receptor signaling pathway,F:G protein-coupled receptor activity | F:protein kinase activator activity,C:cytoplasmic vesicle membrane | C:extracellular exosome | C:plasma membrane | C:signaling receptor complex | C:vesicle +HES2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9Y543,Transcription factor HES-2,Transcriptional repressor of genes that require a bHLH protein for their transcription,P:anterior/posterior pattern specification | P:negative regulation of transcription by RNA polymerase II | P:regulation of neurogenesis,"F:DNA-binding transcription factor activity, RNA polymerase II-specific | F:DNA-binding transcription repressor activity, RNA polymerase II-specific | F:protein dimerization activity | F:RNA polymerase II cis-regulatory region sequence-specific DNA binding | F:sequence-specific double-stranded DNA binding",C:chromatin | C:nucleus +HTATIP2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9BUP3,Protein HTATIP2,Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672),P:negative regulation of cytoplasmic translation | P:positive regulation of programmed cell death | P:positive regulation of transcription by RNA polymerase II | P:protein autophosphorylation,F:protein serine/threonine kinase activity,C:cytoplasm | C:cytosol | C:mitochondrion +HTN1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P15515,Histatin-1,"Histatins (Hsts) are cationic and histidine-rich secreted peptides mainly synthesized by saliva glands of humans and higher primates (PubMed:3286634, PubMed:3944083). Hsts are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be divided into two major groups according to their biological functions: antimicrobial Hsts (e.g. Hst 5/HTN3) and cell-activating Hsts (e.g. Hst 1/HTN1 and Hst 2/HTN1) (PubMed:32225006). Hst 1/HTN1 and Hst 2/HTN1 act in different cell types (epithelium, fibroblasts and endothelium) in oral and non-oral mucosa (PubMed:25903106, PubMed:28542418, PubMed:28751526, PubMed:32225006) | Hst 1 functions pri","P:antimicrobial humoral immune response mediated by antimicrobial peptide | P:defense response to bacterium | P:killing of cells of another organism | P:positive regulation of cell-cell adhesion | P:positive regulation of metabolic process | P:positive regulation of substrate adhesion-dependent cell spreading | P:positive regulation of vascular wound healing | P:positive regulation of wound healing | P:positive regulation of wound healing, spreading of epidermal cells",F:molecular adaptor activity,C:endoplasmic reticulum | C:endoplasmic reticulum membrane | C:extracellular region | C:mitochondrion +IGSF11,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q5DX21,Immunoglobulin superfamily member 11,Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth,P:cell-cell adhesion | P:homophilic cell-cell adhesion | P:positive regulation of long-term synaptic potentiation,F:ionotropic glutamate receptor binding,C:cell-cell junction | C:plasma membrane +KCNAB2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q13303,Voltage-gated potassium channel subunit beta-2,"Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone sub",P:neuromuscular process | P:regulation of potassium ion transmembrane transport | P:regulation of protein localization to cell surface,F:alcohol dehydrogenase (NADP+) activity | F:methylglyoxal reductase (NADPH) (acetol producing) activity | F:potassium channel regulator activity | F:transmembrane transporter binding | F:voltage-gated potassium channel activity,C:axon terminus | C:cytoplasm | C:cytoplasmic side of plasma membrane | C:cytoskeleton | C:cytosol | C:juxtaparanode region of axon | C:membrane | C:pinceau fiber | C:plasma membrane | C:specific granule membrane | C:tertiary granule membrane | C:voltage-gated potassium channel complex +KLF10,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q13118,Krueppel-like factor 10,"Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation",P:cell-cell signaling | P:cellular response to starvation | P:circadian rhythm | P:negative regulation of cell population proliferation | P:negative regulation of DNA-templated transcription | P:negative regulation of transcription by RNA polymerase II | P:positive regulation of transcription by RNA polymerase II | P:regulation of circadian rhythm | P:regulation of transcription by RNA polymerase II,"F:core promoter sequence-specific DNA binding | F:DNA-binding transcription activator activity, RNA polymerase II-specific | F:DNA-binding transcription factor activity | F:DNA-binding transcription factor activity, RNA polymerase II-specific | F:RNA polymerase II cis-regulatory region sequence-specific DNA binding | F:sequence-specific double-stranded DNA binding",C:chromatin | C:nucleus +KRAS,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P01116,GTPase KRas,"Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22711838, PubMed:23698361). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)",P:canonical NF-kappaB signal transduction | P:cardiac muscle cell proliferation | P:cytokine-mediated signaling pathway | P:female pregnancy | P:liver development | P:MAPK cascade | P:myoblast proliferation | P:negative regulation of programmed cell death | P:positive regulation of cell population proliferation | P:positive regulation of cellular senescence | P:positive regulation of gene expression | P:positive regulation of MAPK cascade | P:positive regulation of Ras protein signal transduction | P:positive regulation of TOR signaling | P:Ras protein signal transduction | P:regulation of cell population proliferation | P:response to glucocorticoid | P:response to gravity | P:response to is,F:G protein activity | F:GDP binding | F:GMP binding | F:GTP binding | F:GTPase activity | F:identical protein binding | F:LRR domain binding | F:protein-containing complex binding,C:cytoplasm | C:cytoplasmic side of plasma membrane | C:cytosol | C:endomembrane system | C:endoplasmic reticulum membrane | C:focal adhesion | C:Golgi membrane | C:GTPase complex | C:membrane | C:mitochondrial outer membrane | C:plasma membrane | C:protein phosphatase type 1 complex | C:serine/threonine protein kinase complex +KRT72,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q14CN4,"Keratin, type II cytoskeletal 72",Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable),P:intermediate filament organization | P:keratinization,F:structural constituent of skin epidermis,C:cytosol | C:extracellular exosome | C:keratin filament +KRTAP9-8,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9BYQ0,Keratin-associated protein 9-8,"In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins",,,C:cytosol +L2HGDH,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9H9P8,"L-2-hydroxyglutarate dehydrogenase, mitochondrial","Catalyzes the oxidation of L-2-hydroxyglutarate to 2-oxoglutarate in the mitochondrial matrix (PubMed:15548604, PubMed:16005139, PubMed:40870031). L-2-hydroxyglutarate is a physiological metabolite produced in presence of an elevated NADH/NAD(+) ratio in the mitochondrial matrix: it competes with 2-oxoglutarate and inhibits the activity of some 2-oxoglutarate-dependent dioxygenases, such as KDM4A, KDM4B and KDM4C histone demethylases, thereby acting as an epigenetic regulator (PubMed:41842973). Acts as a negative regulator of macrophage activation by mediating degradation of L-2-hydroxyglutarate, thereby decreasing chromatin accessibility (By similarity). Also regulates inflammation in macro",P:2-oxoglutarate metabolic process | P:tricarboxylic acid cycle,F:(S)-2-hydroxyglutarate dehydrogenase activity,C:membrane | C:mitochondrial inner membrane | C:mitochondrion +LAMTOR5,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O43504,Ragulator complex protein LAMTOR5,"As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22053050, PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:",P:cellular response to amino acid stimulus | P:cellular response to nutrient levels | P:negative regulation of apoptotic process | P:positive regulation of canonical NF-kappaB signal transduction | P:positive regulation of gene expression | P:positive regulation of interleukin-8 production | P:positive regulation of protein localization to nucleus | P:positive regulation of TOR signaling | P:positive regulation of TORC1 signaling | P:protein localization to lysosome | P:regulation of cell size | P:response to virus | P:TORC1 signaling | P:viral genome replication,,C:cytosol | C:FNIP-folliculin RagC/D GAP | C:late endosome membrane | C:lysosomal membrane | C:lysosome | C:protein-containing complex | C:Ragulator complex +LHFPL6,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9Y693,LHFPL tetraspan subfamily member 6 protein,,,,C:membrane +MAOB,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P27338,Amine oxidase [flavin-containing] B,"Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924). Preferentially degrades benzylamine and phenylethylamine (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924)",P:dopamine catabolic process | P:hydrogen peroxide biosynthetic process | P:phenylethylamine catabolic process | P:serotonin metabolic process | P:substantia nigra development,F:electron transfer activity | F:monoamine oxidase activity | F:primary methylamine oxidase activity,C:mitochondrial envelope | C:mitochondrial outer membrane | C:mitochondrion +MINDY2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8NBR6,Ubiquitin carboxyl-terminal hydrolase MINDY-2,"Deubiquitinase that can remove 'Lys-48'- and 'Lys-63'-linked conjugated ubiquitin from proteins (PubMed:27292798). Acts as an inhibitor of TNF-induced RIPK1-mediated cell death by mediating deubiquitination of 'ys-612' of RIPK1, thereby impairing the interaction between RIPK1 and TNFR1 (TNFR1A or TNFR1B), and formation of TNF-R1 signaling complex (By similarity). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312)",,F:cysteine-type carboxypeptidase activity | F:cysteine-type deubiquitinase activity | F:K11-linked polyubiquitin modification-dependent protein binding | F:K48-linked deubiquitinase activity | F:K48-linked polyubiquitin modification-dependent protein binding | F:K6-linked polyubiquitin modification-dependent protein binding | F:K63-linked polyubiquitin modification-dependent protein binding,C:nucleoplasm +MKX,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8IYA7,Homeobox protein Mohawk,May act as a morphogenetic regulator of cell adhesion,P:cell development | P:muscle organ development | P:regulation of transcription by RNA polymerase II,"F:DNA-binding transcription factor activity, RNA polymerase II-specific | F:RNA polymerase II cis-regulatory region sequence-specific DNA binding",C:chromatin | C:nucleus +MT1HL1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P0DM35,Metallothionein 1H-like protein 1,Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids,P:cellular response to cadmium ion | P:cellular response to copper ion | P:cellular response to zinc ion | P:detoxification of copper ion | P:intracellular zinc ion homeostasis,F:metal ion binding,C:cytoplasm | C:nucleus +MTARC1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q5VT66,Mitochondrial amidoxime-reducing component 1,"Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the",P:cellular detoxification of nitrogen compound | P:detoxification of nitrogen compound | P:nitrate metabolic process | P:nitric oxide biosynthetic process,"F:molybdenum ion binding | F:molybdopterin cofactor binding | F:nitrate reductase activity | F:nitrite reductase activity | F:oxidoreductase activity, acting on other nitrogenous compounds as donors | F:pyridoxal phosphate binding",C:mitochondrial outer membrane | C:mitochondrion | C:nitric-oxide synthase complex +NEFH,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P12036,Neurofilament heavy polypeptide,"Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)",P:axon development | P:axonal transport of mitochondrion | P:axonogenesis | P:intermediate filament bundle assembly | P:neurofilament bundle assembly | P:neuron projection organization,F:dynein complex binding | F:kinesin binding | F:microtubule binding | F:protein kinase binding | F:protein-macromolecule adaptor activity | F:structural constituent of cytoskeleton | F:structural constituent of postsynaptic intermediate filament cytoskeleton,C:axon | C:axon cytoplasm | C:cytoplasm | C:cytoskeleton | C:neurofibrillary tangle | C:neurofilament +NEUROG3,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9Y4Z2,Neurogenin-3,"Is a transcriptional regulator involved in the control of enteroendocrine cell differentiation (PubMed:21378176). Together with NKX2-2, initiates transcriptional activation of NEUROD1 (PubMed:16855267, PubMed:21378176). Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity)",P:axon development | P:central nervous system development | P:enteroendocrine cell differentiation | P:forebrain development | P:hindbrain development | P:negative regulation of transcription by RNA polymerase II | P:nervous system development | P:peripheral nervous system development | P:positive regulation of DNA-templated transcription | P:positive regulation of neuron differentiation | P:positive regulation of transcription by RNA polymerase II | P:sensory organ development | P:spinal cord development | P:transdifferentiation,"F:chromatin DNA binding | F:DNA-binding transcription activator activity, RNA polymerase II-specific | F:DNA-binding transcription factor activity, RNA polymerase II-specific | F:DNA-binding transcription repressor activity, RNA polymerase II-specific | F:E-box binding | F:protein dimerization activity | F:RNA polymerase II cis-regulatory region sequence-specific DNA binding",C:chromatin | C:nucleus +NRAS,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P01111,GTPase NRas,Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:30712867). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:30712867). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300),P:MAPK cascade | P:positive regulation of cell population proliferation | P:positive regulation of endothelial cell proliferation | P:positive regulation of Ras protein signal transduction | P:Ras protein signal transduction,F:G protein activity | F:GTP binding | F:GTPase activity | F:protein-containing complex binding,C:cytosol | C:endoplasmic reticulum membrane | C:extracellular exosome | C:Golgi apparatus | C:Golgi membrane | C:membrane | C:plasma membrane | C:tertiary granule membrane +NYNRIN,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9P2P1,Protein NYNRIN,,P:3'-UTR-mediated mRNA destabilization | P:DNA integration | P:DNA-templated DNA replication,F:DNA-directed DNA polymerase activity | F:mRNA binding | F:RNA endonuclease activity | F:RNA-DNA hybrid ribonuclease activity,C:chromosome | C:cytoplasmic ribonucleoprotein granule | C:membrane | C:nucleus +OR1E1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P30953,Olfactory receptor 1E1,Odorant receptor,P:sensory perception of smell | P:signal transduction,F:G protein-coupled receptor activity | F:olfactory receptor activity,C:plasma membrane +OR2T29,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8NH02,Olfactory receptor 2T29,Odorant receptor,P:detection of chemical stimulus involved in sensory perception of smell,F:G protein-coupled receptor activity | F:olfactory receptor activity,C:plasma membrane +OR4C13,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8NGP0,Olfactory receptor 4C13,Odorant receptor,,F:G protein-coupled receptor activity | F:olfactory receptor activity,C:plasma membrane +OR6S1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8NH40,Olfactory receptor 6S1,Odorant receptor,,F:G protein-coupled receptor activity | F:olfactory receptor activity,C:plasma membrane +OR8B2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q96RD0,Olfactory receptor 8B2,Odorant receptor,P:G protein-coupled receptor signaling pathway | P:sensory perception of smell,F:G protein-coupled receptor activity | F:olfactory receptor activity,C:plasma membrane +PACSIN1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9BY11,Protein kinase C and casein kinase substrate in neurons protein 1,"Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cy",P:actin filament organization | P:cytoskeleton organization | P:neuron projection morphogenesis | P:plasma membrane tubulation | P:positive regulation of dendrite development | P:protein localization to membrane | P:protein localization to plasma membrane | P:regulation of endocytosis | P:synaptic vesicle endocytosis,F:identical protein binding | F:phospholipid binding,C:axon terminus | C:cytoplasm | C:cytoplasmic vesicle membrane | C:cytosol | C:endosome | C:perinuclear region of cytoplasm | C:plasma membrane | C:ruffle membrane | C:synapse +PDLIM1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O00151,PDZ and LIM domain protein 1,"Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity)",P:actin cytoskeleton organization | P:establishment or maintenance of actin cytoskeleton polarity | P:fibroblast migration | P:heart development | P:maintenance of cell polarity | P:muscle structure development | P:response to hypoxia | P:response to oxidative stress | P:stress fiber assembly,F:actin binding | F:cadherin binding involved in cell-cell adhesion | F:muscle alpha-actinin binding,C:actin cytoskeleton | C:adherens junction | C:cytoplasm | C:cytoskeleton | C:filamentous actin | C:focal adhesion | C:stress fiber | C:Z disc +PIK3CA,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P42336,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396, PubMed:28676499). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activ",P:actin cytoskeleton organization | P:anoikis | P:cardiac muscle cell contraction | P:cardiac muscle contraction | P:cell migration | P:cellular response to hydrostatic pressure | P:cellular response to insulin stimulus | P:endothelial cell migration | P:epidermal growth factor receptor signaling pathway | P:insulin receptor signaling pathway | P:interleukin-8-mediated signaling pathway | P:negative regulation of actin filament depolymerization | P:negative regulation of anoikis | P:negative regulation of gene expression | P:negative regulation of macroautophagy | P:neutrophil chemotaxis | P:phosphatidylinositol 3-kinase/protein kinase B signal transduction | P:phosphatidylinositol phosphate,"F:1-phosphatidylinositol-3-kinase activity | F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity | F:1-phosphatidylinositol-4-phosphate 3-kinase activity | F:protein kinase activator activity | F:protein serine kinase activity | F:protein serine/threonine kinase activity","C:cytoplasm | C:cytosol | C:intercalated disc | C:perinuclear region of cytoplasm | C:phosphatidylinositol 3-kinase complex | C:phosphatidylinositol 3-kinase complex, class IA | C:phosphatidylinositol 3-kinase complex, class IB | C:plasma membrane" +PLA2G4D,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q86XP0,Cytosolic phospholipase A2 delta,Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560),P:fatty acid metabolic process | P:glycerophospholipid catabolic process | P:phosphatidylglycerol acyl-chain remodeling | P:phosphatidylinositol acyl-chain remodeling,F:A2-type glycerophospholipase activity | F:calcium ion binding | F:calcium-dependent phospholipid binding | F:glycerophospholipid phospholipase A1 activity,C:cytosol | C:membrane +PLEKHJ1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9NW61,Pleckstrin homology domain-containing family J member 1,,P:vesicle-mediated transport,F:ceramide transfer activity, +POTEM,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,A6NI47,Putative POTE ankyrin domain family member M,,,, +PPIAL4G,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P0DN37,Peptidyl-prolyl cis-trans isomerase A-like 4G,PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity),P:protein folding,F:peptidyl-prolyl cis-trans isomerase activity,C:cytoplasm | C:nucleus +PPIB,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P23284,Peptidyl-prolyl cis-trans isomerase B,Peptidyl-prolyl cis-trans isomerase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding,P:bone development | P:host-mediated activation of viral genome replication | P:host-mediated activation of viral process | P:neutrophil chemotaxis | P:positive regulation of multicellular organism growth | P:protein folding | P:protein stabilization,F:peptidyl-prolyl cis-trans isomerase activity | F:RNA binding | F:RNA polymerase binding,C:cytosol | C:endoplasmic reticulum | C:endoplasmic reticulum chaperone complex | C:endoplasmic reticulum lumen | C:extracellular exosome | C:focal adhesion | C:melanosome | C:membrane | C:nucleus | C:perinuclear region of cytoplasm | C:protein-containing complex | C:smooth endoplasmic reticulum +PRAMEF11,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O60813,PRAME family member 11,,P:negative regulation of apoptotic process | P:negative regulation of cell differentiation | P:negative regulation of DNA-templated transcription | P:positive regulation of cell population proliferation | P:proteasome-mediated ubiquitin-dependent protein catabolic process,F:ubiquitin-like ligase-substrate adaptor activity,C:Cul2-RING ubiquitin ligase complex | C:cytoplasm +PRAMEF12,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,O95522,PRAME family member 12,,P:negative regulation of apoptotic process | P:negative regulation of cell differentiation | P:negative regulation of DNA-templated transcription | P:positive regulation of cell population proliferation | P:proteasome-mediated ubiquitin-dependent protein catabolic process,F:ubiquitin-like ligase-substrate adaptor activity,C:Cul2-RING ubiquitin ligase complex | C:cytoplasm +PRIM1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P49642,DNA primase small subunit,"Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed:17893144, PubMed:24043831, PubMed:25550159, PubMed:26975377, PubMed:31479243, PubMed:33060134, PubMed:9268648, PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By simila","P:DNA replication initiation | P:DNA replication, synthesis of primer",F:DNA-directed RNA polymerase activity | F:magnesium ion binding | F:ribonucleotide binding | F:zinc ion binding,C:alpha DNA polymerase:primase complex | C:membrane | C:nucleoplasm +PRR35,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P0CG20,Proline-rich protein 35,,,, +RAET1E,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8TD07,Retinoic acid early transcript 1E,"Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity","P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent | P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib | P:natural killer cell mediated cytotoxicity | P:positive regulation of natural killer cell mediated cytotoxicity | P:positive regulation of T cell mediated cytotoxicity",F:natural killer cell lectin-like receptor binding | F:receptor ligand activity,C:cytosol | C:external side of plasma membrane | C:extracellular region | C:focal adhesion | C:membrane | C:plasma membrane +RNASEK,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q6P5S7,Ribonuclease kappa,"Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds and hydrolyzes UpU bonds at a lower rate (PubMed:17881363). Degrades circular RNAs (circRNAs), preferentially over their cognate linear transcripts, and limits their age-associated accumulation (PubMed:41742417). Acts synergistically with the lysosome in circRNA turnover, degrading circRNAs outside the organelle while lysosome-resident RNASE1 degrades circRNAs within the lysosomal lumen (PubMed:41926286). Contributes to the decrease in global circRNA levels induced by heat shock and endoplasmic reticulum stress and is required for proper induction of the stress response (PubMed:41926286). Together with the chapero",P:endosomal lumen acidification | P:Golgi lumen acidification | P:intracellular pH reduction | P:lysosomal lumen acidification | P:proton transmembrane transport | P:receptor-mediated endocytosis | P:receptor-mediated endocytosis of virus by host cell | P:vacuolar acidification,F:RNA endonuclease activity,"C:clathrin-coated vesicle membrane | C:endomembrane system | C:endosome membrane | C:Golgi membrane | C:lysosomal membrane | C:membrane | C:plasma membrane | C:proton-transporting V-type ATPase complex | C:vacuolar proton-transporting V-type ATPase, V0 domain" +RPL13A,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P40429,Large ribosomal subunit protein uL13,"Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the ",P:cellular response to type II interferon | P:cytoplasmic translation | P:negative regulation of formation of translation preinitiation complex | P:negative regulation of myoblast fusion | P:negative regulation of translation | P:spermatogenesis | P:striated muscle contraction | P:translation,F:mRNA binding | F:RNA binding | F:structural constituent of ribosome,C:cytoplasm | C:cytosol | C:cytosolic large ribosomal subunit | C:cytosolic ribosome | C:focal adhesion | C:GAIT complex | C:large ribosomal subunit | C:membrane | C:nucleolus | C:nucleus | C:ribonucleoprotein complex | C:ribosome +SLAIN2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9P270,SLAIN motif-containing protein 2,Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase,P:cytoplasmic microtubule organization | P:microtubule nucleation | P:positive regulation of microtubule polymerization,,C:centrosome | C:ciliary basal body | C:ciliary tip | C:cytosol | C:microtubule cytoskeleton +SLC25A22,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q9H936,Mitochondrial glutamate carrier 1,Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (PubMed:11897791). Plays a role in the control of glucose-stimulated insulin secretion (By similarity),P:aspartate transmembrane transport | P:L-glutamate transmembrane transport | P:malate-aspartate shuttle | P:neurotransmitter transport | P:regulation of insulin secretion,F:amino acid:proton symporter activity | F:L-aspartate transmembrane transporter activity | F:L-glutamate transmembrane transporter activity,C:mitochondrial inner membrane | C:mitochondrion +SPINK2,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P20155,Serine protease inhibitor Kazal-type 2,"As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin",P:acrosome assembly | P:spermatid development,F:endopeptidase inhibitor activity | F:serine-type endopeptidase inhibitor activity,C:acrosomal vesicle | C:extracellular region +TLCD1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q96CP7,TLC domain-containing protein 1,Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349),P:membrane assembly | P:phospholipid homeostasis | P:plasma membrane organization | P:regulation of membrane lipid distribution,,C:plasma membrane +TMEM219,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q86XT9,Insulin-like growth factor-binding protein 3 receptor,"Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding",P:apoptotic process | P:ERK1 and ERK2 cascade | P:negative regulation of inflammatory response | P:positive regulation of ERK1 and ERK2 cascade | P:regulation of transforming growth factor beta1 production | P:transforming growth factor beta1 production,,C:plasma membrane | C:signaling receptor complex +TNFSF8,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P32971,Tumor necrosis factor ligand superfamily member 8,Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells,"P:CD8-positive, alpha-beta T cell differentiation | P:cell-cell signaling | P:immune response | P:regulation of T cell proliferation",F:signaling receptor binding | F:tumor necrosis factor receptor binding,C:plasma membrane +TP53,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,P04637,Cellular tumor antigen p53,"Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958","P:autophagy | P:bone marrow development | P:cellular response to actinomycin D | P:cellular response to gamma radiation | P:cellular response to glucose starvation | P:cellular response to hypoxia | P:cellular response to ionizing radiation | P:cellular response to UV | P:cellular response to xenobiotic stimulus | P:cellular senescence | P:circadian behavior | P:determination of adult lifespan | P:DNA damage response | P:DNA damage response, signal transduction by p53 class mediator | P:entrainment of circadian clock by photoperiod | P:ER overload response | P:hematopoietic progenitor cell differentiation | P:hematopoietic stem cell differentiation | P:intracellular protein localization | P:","F:14-3-3 protein binding | F:ATP-dependent DNA/DNA annealing activity | F:chromatin binding | F:cis-regulatory region sequence-specific DNA binding | F:copper ion binding | F:core promoter sequence-specific DNA binding | F:disordered domain specific binding | F:DNA binding | F:DNA-binding transcription activator activity, RNA polymerase II-specific | F:DNA-binding transcription factor activity | F:DNA-binding transcription factor activity, RNA polymerase II-specific | F:DNA-binding transcription repressor activity, RNA polymerase II-specific | F:enzyme binding | F:general transcription initiation factor binding | F:histone deacetylase binding | F:identical protein binding | F:MDM2/MDM4 famil",C:centrosome | C:chromatin | C:cytoplasm | C:cytosol | C:endoplasmic reticulum | C:mitochondrial matrix | C:mitochondrion | C:nuclear matrix | C:nucleolus | C:nucleoplasm | C:nucleus | C:PML body | C:protein-containing complex | C:transcription regulator complex | C:transcription repressor complex +TP53BP1,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q12888,TP53-binding protein 1,"Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation ",P:DNA damage checkpoint signaling | P:DNA damage response | P:double-strand break repair via classical nonhomologous end joining | P:double-strand break repair via nonhomologous end joining | P:negative regulation of double-strand break repair via homologous recombination | P:positive regulation of DNA-templated transcription | P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | P:positive regulation of isotype switching | P:positive regulation of transcription by RNA polymerase II | P:protein homooligomerization | P:protein localization to site of double-strand break,F:histone H4K20me methyltransferase activity | F:histone H4K20me2 reader activity | F:histone reader activity | F:p53 binding | F:RNA polymerase II-specific DNA-binding transcription factor binding | F:transcription coactivator activity | F:transcription coregulator activity | F:ubiquitin-modified histone reader activity,C:chromosome | C:cytoplasm | C:nuclear body | C:nucleoplasm | C:nucleus | C:site of double-strand break +ZDHHC12,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q96GR4,Palmitoyltransferase ZDHHC12,"Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:36586411). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Negatively regulates NLRP3-driven inflammation. Catalyzes NLRP3 palmitoylation, leading to its degradation via the chaperone-mediated autophagy (CMA) process (PubMed:36586411, PubMed:39225180)","P:gephyrin clustering involved in postsynaptic density assembly | P:negative regulation of NLRP3 inflammasome complex assembly | P:peptidyl-L-cysteine S-palmitoylation | P:positive regulation of synaptic transmission, GABAergic | P:protein targeting to membrane",F:palmitoyltransferase activity | F:protein-cysteine S-palmitoyltransferase activity,C:dendritic spine | C:endoplasmic reticulum | C:endoplasmic reticulum membrane | C:Golgi apparatus | C:Golgi membrane +ZIC4,ANNOTATED_NOT_FUNCTIONAL_VALIDATION,Q8N9L1,Zinc finger protein ZIC 4,Binds to DNA,P:central nervous system development | P:regulation of transcription by RNA polymerase II,"F:DNA binding | F:DNA-binding transcription factor activity, RNA polymerase II-specific | F:RNA polymerase II cis-regulatory region sequence-specific DNA binding | F:sequence-specific double-stranded DNA binding",C:nucleus diff --git a/results/Main_C1_C2/C1_Primary_PanCancer_BY_05.csv b/results/Main_C1_C2/C1_Primary_PanCancer_BY_05.csv new file mode 100644 index 0000000000000000000000000000000000000000..c336235694a47d0c786d69fb03c3a449a93be894 --- /dev/null +++ b/results/Main_C1_C2/C1_Primary_PanCancer_BY_05.csv @@ -0,0 +1,84 @@ +beta,se_hc3,t_hc3,p,ci_low,ci_high,n_gene,gene,A,B,Scope,Lineage,test_kind,q_within,q_global_BH,q_global_BY,q_pair_BH,q_pair_BY,discovery_signal,primary_pan_cancer_signal,inferential_tier,dependence_robust_signal,context_type,gene_effect_global_mean,gene_effect_global_frac_lt_minus_0_5,possible_general_essentiality,A_symbol,B_symbol,gene_symbol 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+-0.6206702665037973,0.0731258908796729,-8.487695110957306,7.31467003505931e-16,-0.764523569013355,-0.4768169639942395,340.0,ENTREZ:5290,ENTREZ:7157,ENTREZ:5290,pan_cancer_conditional,PAN_CANCER,conditional,1.3010603591359992e-11,4.967113146706839e-09,8.899927369258888e-08,4.996071779082237e-09,4.065581650016508e-08,True,True,precision_eligible,True,pan_cancer_conditional,-0.48594087,0.3904923599320883,False,TP53,PIK3CA,PIK3CA +-1.3350632067960593,0.1569067095420205,-8.508643197558875,7.668485702786195e-15,-1.644736244111744,-1.0253901694803746,182.0,ENTREZ:4893,ENTREZ:7157,ENTREZ:4893,pan_cancer_conditional,PAN_CANCER,conditional,1.3639935519545806e-10,3.7195541842699805e-08,6.664587881992054e-07,3.741239456789707e-08,3.0444547549386987e-07,True,True,precision_eligible,True,pan_cancer_conditional,-0.26543957,0.0831918505942275,False,TP53,NRAS,NRAS +-0.1422393479163315,0.0170522093714025,-8.3414028539243,2.0641495165840483e-14,-0.1758924694970843,-0.1085862263355787,182.0,ENTREZ:9124,ENTREZ:7157,ENTREZ:546,pan_cancer_conditional,PAN_CANCER,conditional,3.671502745148047e-10,8.760532046773025e-08,1.5696863878375136e-06,8.811606588355312e-08,7.170494667985482e-07,True,True,precision_eligible,True,pan_cancer_conditional,-0.05486635,0.0,False,TP53,ATRX,PDLIM1 +-0.2093218233136288,0.0242561906375533,-8.629624760186283,2.8956627171557764e-14,-0.2573433505535891,-0.1613002960736686,125.0,ENTREZ:390999,ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,conditional,5.150515275004979e-10,1.0924077748988593e-07,1.95734414881598e-06,1.0987765920010625e-07,8.941356624639607e-07,True,True,precision_eligible,True,pan_cancer_conditional,-0.07585081,0.005942275042444821,False,TP53,BRIP1,PRAMEF12 +-0.1815025660300815,0.0213779116249951,-8.490191615249639,6.149178178240633e-14,-0.2238257807826812,-0.1391793512774818,125.0,ENTREZ:283078,ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,conditional,5.468771612818307e-10,2.0878360626101844e-07,3.740923302395388e-06,1.0987765920010625e-07,8.941356624639607e-07,True,True,precision_eligible,True,pan_cancer_conditional,0.11189638,0.0,False,TP53,BRIP1,MKX +-0.1076127681410301,0.0128680041886691,-8.362817307425807,3.523062656277573e-13,-0.1331394269953507,-0.0820861092867095,105.0,ENTREZ:83901,ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,conditional,6.311919054986898e-09,8.544204783378155e-07,1.5309255044966268e-05,9.322218911980652e-07,7.586008332519904e-06,True,True,precision_eligible,True,pan_cancer_conditional,-0.095512435,0.0028763183125599234,False,TP53,EPHA7,KRTAP9-8 +-0.1210771384124408,0.0146304615081908,-8.275688251163885,5.139890592457064e-13,-0.1500965894435448,-0.0920576873813368,106.0,ENTREZ:84320,ENTREZ:7157,ENTREZ:26047,pan_cancer_conditional,PAN_CANCER,conditional,9.142323396803376e-09,1.1634344867715906e-06,2.084607723909631e-05,1.2538043515616061e-06,1.0202903780850196e-05,True,True,precision_eligible,True,pan_cancer_conditional,0.08075888,0.0,False,TP53,CNTNAP2,ACBD6 +-0.1507807162573974,0.0190405531186427,-7.918925218079258,8.988997795156755e-13,-0.1884474722445955,-0.1131139602701992,135.0,ENTREZ:146325,ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,conditional,1.610468844980284e-08,1.907526625860979e-06,3.417850152325546e-05,2.0614001215747637e-06,1.6774760007862984e-05,True,True,precision_eligible,True,pan_cancer_conditional,0.08612436,0.0,False,TP53,ASTN1,PRR35 +-0.135267586461926,0.0172227715852416,-7.85399642516526,1.2788549251817521e-12,-0.1693383369638837,-0.1011968359599683,135.0,ENTREZ:51084,ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,conditional,2.2911964839556272e-08,2.285319876341801e-06,4.0947689964442364e-05,2.587704264232238e-06,2.1057589717545336e-05,True,True,precision_eligible,True,pan_cancer_conditional,0.108311296,0.0,False,TP53,CTNNB1,CRYL1 +-0.5396753485849619,0.0667715959576167,-8.082409007080207,1.2164474322199424e-12,-0.6720859290680695,-0.4072647681018543,108.0,ENTREZ:1719,ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,conditional,1.0896936097826245e-08,2.285319876341801e-06,4.0947689964442364e-05,9.322218911980652e-07,7.586008332519904e-06,True,True,precision_eligible,True,pan_cancer_conditional,-0.85811836,0.7478753541076487,False,TP53,EPHA7,DHFR +-0.3940936007462384,0.0435941468442493,-9.04005765164378,1.823499613346283e-12,-0.4814582233113972,-0.3067289781810796,59.0,ENTREZ:7555,ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,conditional,3.2434587622590335e-08,2.8142476504732347e-06,5.042486238696814e-05,3.113720411768672e-06,2.53380758506516e-05,True,True,precision_eligible,True,pan_cancer_conditional,-0.14572497,0.021222410865874362,False,TERT,ATM,CNBP +-0.08191342192341,0.0106460798397444,-7.694233291169458,3.0322384745748323e-12,-0.1029739073539125,-0.0608529364929074,135.0,ENTREZ:84885,ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,conditional,5.393442574726254e-08,4.1181547544376185e-06,7.378788670067345e-05,4.502263395179459e-06,3.663742286413882e-05,True,True,precision_eligible,True,pan_cancer_conditional,0.045302536,0.0,False,TP53,PREX2,ZDHHC12 +-0.1548810330665694,0.0204645053299065,-7.568276416641679,4.027885401774996e-12,-0.1953283003201801,-0.1144337658129587,150.0,ENTREZ:1796,ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,conditional,3.582199882068592e-08,5.065154058668074e-06,9.075594194213218e-05,2.5311773649289936e-06,2.0597598879339613e-05,True,True,precision_eligible,True,pan_cancer_conditional,-0.1267129,0.0,False,TP53,NBN,DOK1 +-0.2400078629565078,0.0275479165320589,-8.71237803690883,6.114973567045833e-12,-0.2952151213730653,-0.1848006045399503,59.0,ENTREZ:5479,ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,conditional,5.4383517418522117e-08,7.159388068431095e-06,0.00012827981150302574,3.113720411768672e-06,2.53380758506516e-05,True,True,precision_eligible,True,pan_cancer_conditional,-0.102264665,0.001697792869269949,False,TERT,ATM,PPIB +-0.1669111320160176,0.0195327542116275,-8.545191845841064,1.1374719521111744e-11,-0.2060556461970989,-0.1277666178349363,59.0,ENTREZ:54626,ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,conditional,6.744071204067153e-08,1.2458286677412371e-05,0.00022322391960788527,3.113720411768672e-06,2.53380758506516e-05,True,True,precision_eligible,True,pan_cancer_conditional,0.02690069,0.0,False,TERT,ATM,HES2 +-0.1567665833091063,0.0216212099624376,-7.250592523797507,4.2792168681738867e-11,-0.1995714712936455,-0.1139616953245671,125.0,ENTREZ:25841,ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,conditional,2.5555483136734457e-07,4.2733129333483226e-05,0.0007656796535454359,9.322218911980652e-07,7.586008332519904e-06,True,True,precision_eligible,True,pan_cancer_conditional,0.08581477,0.0008488964346349745,False,TP53,EPHA7,ABTB2 +-0.2761298509541908,0.0315774204704331,-8.744534760612849,7.969900150137505e-11,-0.3399501983563369,-0.2123095035520447,44.0,ENTREZ:7071,ENTREZ:324,ENTREZ:9585,pan_cancer_conditional,PAN_CANCER,conditional,1.417606139704958e-06,6.938531924577752e-05,0.0012432257601977018,9.720727815119711e-05,0.0007910297204980417,True,True,precision_eligible,True,pan_cancer_conditional,-0.16518903,0.03480475382003396,False,APC,KIF20B,KLF10 +-0.1479065712039866,0.0204850579406675,-7.22021737172431,8.850492927189212e-11,-0.1885292098312795,-0.1072839325766936,108.0,ENTREZ:341799,ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,conditional,1.5856543128352194e-06,7.512539793792793e-05,0.0013460748033845657,0.0001041167154611385,0.0008472556571566166,True,True,precision_eligible,True,pan_cancer_conditional,-0.03862277,0.0,False,TP53,KCNT2,OR6S1 +-0.1153289367380744,0.0165957627152374,-6.949300174808146,9.571496677284588e-11,-0.1481119928356621,-0.0825458806404866,160.0,ENTREZ:152404,ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,conditional,8.512410569943049e-07,7.926387748537591e-05,0.0014202268637536152,3.5036725300167764e-06,2.8511333254543e-05,True,True,precision_eligible,True,pan_cancer_conditional,-0.020709602,0.0008488964346349745,False,TP53,PPP1R9A,IGSF11 +-0.6690480767468656,0.0959682559193068,-6.9715560665124805,1.1837873059324873e-10,-0.858806449096913,-0.4792897043968183,148.0,ENTREZ:7157,ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,conditional,1.0528012405310574e-06,9.569818600707281e-05,0.0017146919743462076,4.996071779082237e-09,4.065581650016508e-08,True,True,precision_eligible,True,pan_cancer_conditional,0.3786678,0.003395585738539898,False,TERT,TP53,TP53 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Neck;Lung;Uterus,-0.08421024465656152,-0.05497635051867547,0.051458559140237,0.2853574145696922,0.6752305700968727,0.0048012880575075325,0.04600029180889299,exploratory_cross_lineage_meta_analysis,0.5677230377602516 +ENTREZ:7157,ENTREZ:2195,ENTREZ:57084,3,Head and Neck;Lung;Uterus,-0.08360126670362251,-0.06699335018658323,0.04099886148640097,0.10225265111459575,0.7434977788260324,0.0036230620921610937,0.02027023515490398,exploratory_cross_lineage_meta_analysis,0.3318726395824599 +ENTREZ:7157,ENTREZ:2195,ENTREZ:408187,3,Head and Neck;Lung;Uterus,-0.1100334639450444,-0.08702561531240936,0.07341078567836021,0.23583526930447496,0.8324078244661178,0.013177005479515369,0.0025622597950298136,exploratory_cross_lineage_meta_analysis,0.5371117278986081 +ENTREZ:7157,ENTREZ:2195,ENTREZ:51298,3,Head and 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Neck;Lung;Uterus,-0.10265657929433217,-0.09086370114000686,0.04061306619621995,0.02526659748027357,0.7939720709392674,0.0035595119141166045,0.007799381246562565,exploratory_cross_lineage_meta_analysis,0.10459000016832996 +ENTREZ:7157,ENTREZ:2195,ENTREZ:10388,3,Head and Neck;Lung;Uterus,-0.05999993065036544,-0.03280285877197035,0.03575114930002723,0.35886341593787296,0.7571785528543511,0.002619553708740721,0.0162729286772936,exploratory_cross_lineage_meta_analysis,0.6138636078827687 +ENTREZ:7157,ENTREZ:2195,ENTREZ:115572,3,Head and Neck;Lung;Uterus,-0.08107859210905119,-0.043598554608033725,0.06295230198645296,0.48858264527853623,0.8233107803265198,0.009196873489230834,0.003483719077995202,exploratory_cross_lineage_meta_analysis,0.7006281792666038 +ENTREZ:7157,ENTREZ:2195,ENTREZ:9218,3,Head and Neck;Lung;Uterus,-0.09766763922487656,-0.059670360191605674,0.10120629238843237,0.5554646149480449,0.9533769210032139,0.029177694063408664,4.841603867001577e-10,exploratory_cross_lineage_meta_analysis,0.72366868848865 +ENTREZ:7157,ENTREZ:2196,ENTREZ:146223,2,Bowel;Lung,-0.1109589084603707,-0.1109589084603707,0.02076706495599661,9.140909271759855e-08,0.0,0.0,0.8752883861904976,exploratory_cross_lineage_meta_analysis,8.900359027766175e-07 +ENTREZ:7157,ENTREZ:2196,ENTREZ:3060,2,Bowel;Lung,-0.07539820666779898,-0.02298131023508063,0.08090173134529008,0.7763609481540357,0.9283093583126419,0.012182160040145707,0.00018785533536101872,exploratory_cross_lineage_meta_analysis,0.8445709966121058 +ENTREZ:7157,ENTREZ:2196,ENTREZ:79829,2,Bowel;Lung,-0.12133994312189585,-0.05022879721913303,0.12231436315418419,0.6813267727220644,0.8980014351908897,0.02698681591331263,0.0017412706313568549,exploratory_cross_lineage_meta_analysis,0.8018922537318744 +ENTREZ:7157,ENTREZ:2196,ENTREZ:642658,2,Bowel;Lung,-0.10928163930888253,-0.10928163930888253,0.01997032837805805,4.444817423265499e-08,0.0,0.0,0.8426117894667917,exploratory_cross_lineage_meta_analysis,5.873508737886552e-07 +ENTREZ:7157,ENTREZ:2196,ENTREZ:159371,2,Bowel;Lung,-0.10488443701332209,-0.09628960629467798,0.034858320012512316,0.005739334887868196,0.20404924928180926,0.0009545955453781597,0.2623413826448657,exploratory_cross_lineage_meta_analysis,0.03033648440730332 +ENTREZ:7157,ENTREZ:2196,ENTREZ:6672,2,Bowel;Lung,-0.10668747233691112,-0.04048989554318895,0.09166451318021272,0.6586930449220931,0.813817248102062,0.014049315422935438,0.02047345210530929,exploratory_cross_lineage_meta_analysis,0.7861820213586272 +ENTREZ:7157,ENTREZ:2196,ENTREZ:126374,2,Bowel;Lung,-0.09529666595233495,-0.02921179912470124,0.09286343305284302,0.753090212682322,0.8515305775964218,0.014912651248484574,0.009451837372885461,exploratory_cross_lineage_meta_analysis,0.8445709966121058 +ENTREZ:7157,ENTREZ:2196,ENTREZ:220992,2,Bowel;Lung,-0.07931556859163635,0.004626936489331805,0.10672177602640084,0.9654184449983417,0.8774336812570099,0.0202284078758872,0.004285157496097919,exploratory_cross_lineage_meta_analysis,0.9759694662551542 +ENTREZ:7157,ENTREZ:23345,ENTREZ:51496,2,Bowel;Lung,-0.21385115614492684,-0.21385115614492684,0.03978105347459404,7.62841550195932e-08,0.0,0.0,0.4180237036766492,exploratory_cross_lineage_meta_analysis,8.820355424140463e-07 +ENTREZ:7157,ENTREZ:23345,ENTREZ:2595,2,Bowel;Lung,-0.12079269250545153,-0.07742632661392607,0.07458953355428685,0.2992551329364823,0.7358048098122225,0.008544243781635982,0.05171143024001136,exploratory_cross_lineage_meta_analysis,0.5707443257036003 +ENTREZ:7157,ENTREZ:23345,ENTREZ:220064,2,Bowel;Lung,-0.3753169772906978,-0.3753169772906978,0.06360169799006682,3.611893074400773e-09,0.0,0.0,0.5719221882206462,exploratory_cross_lineage_meta_analysis,6.68200218764143e-08 +ENTREZ:7157,ENTREZ:23345,ENTREZ:5330,2,Bowel;Lung,-0.11769699675602753,-0.11924256018410774,0.09507614508565762,0.20977673843588962,0.9540116944464213,0.017247537193642287,3.114558243756761e-06,exploratory_cross_lineage_meta_analysis,0.4980671727551943 +ENTREZ:7157,ENTREZ:23345,ENTREZ:55319,2,Bowel;Lung,-0.16339757579391484,-0.03994837323919772,0.17013247411763016,0.8143581813402005,0.8294923573623796,0.04908768212835453,0.015446264901692043,exploratory_cross_lineage_meta_analysis,0.8759085089996342 +ENTREZ:7157,ENTREZ:23345,ENTREZ:57583,2,Bowel;Lung,-0.17997047238066846,-0.07707200954829387,0.1526735475432174,0.6136882610750429,0.8538102110066824,0.04033334110927021,0.008911773249971553,exploratory_cross_lineage_meta_analysis,0.7735844378365407 +ENTREZ:7157,ENTREZ:27445,ENTREZ:57106,2,Lung;Uterus,-0.14396591072746812,-0.14396591072746812,0.028659777125961187,5.079801580516883e-07,0.0,0.0,0.4430504971569481,exploratory_cross_lineage_meta_analysis,4.698816461978117e-06 +ENTREZ:7157,ENTREZ:27445,ENTREZ:729956,2,Lung;Uterus,-0.09737906590332823,-0.07725139022256179,0.04281410892298737,0.07117736069546003,0.5202968002874413,0.0022658111679612946,0.1487890169656947,exploratory_cross_lineage_meta_analysis,0.24844927789924726 +ENTREZ:7157,ENTREZ:2956,ENTREZ:412,2,Bowel;Uterus,-0.15279332084864997,-0.09857228036615043,0.15307360638319098,0.5196056055879734,0.9464805978168898,0.0443727692154101,1.5420585696551115e-05,exploratory_cross_lineage_meta_analysis,0.7060176674318913 +ENTREZ:7157,ENTREZ:324,ENTREZ:10286,3,Bowel;Esophagus/Stomach;Uterus,-0.23148440353875777,-0.10920015499176111,0.18453959836387185,0.554022191482342,0.8669400910311038,0.08253241321106647,0.0005446257344102114,exploratory_cross_lineage_meta_analysis,0.72366868848865 +ENTREZ:7157,ENTREZ:324,ENTREZ:339479,3,Bowel;Esophagus/Stomach;Uterus,-0.06483021346581974,-0.06483021346581974,0.011283357086986641,9.156888477522366e-09,0.0,0.0,0.4026095784557353,exploratory_cross_lineage_meta_analysis,1.4116869736180313e-07 +ENTREZ:7157,ENTREZ:324,ENTREZ:84893,3,Bowel;Esophagus/Stomach;Uterus,-0.09999902775774812,-0.08470572524218876,0.03790571206035676,0.025440810851755938,0.6858823425519476,0.0024857964644284217,0.04143951047518661,exploratory_cross_lineage_meta_analysis,0.10459000016832996 +ENTREZ:7157,ENTREZ:324,ENTREZ:3693,3,Bowel;Esophagus/Stomach;Uterus,-0.34159186799559416,-0.26274348960460014,0.17793166072581773,0.13976842214436921,0.79425659623235,0.07081001857616254,0.007747205066775613,exploratory_cross_lineage_meta_analysis,0.42157769089522973 +ENTREZ:7157,ENTREZ:324,ENTREZ:57082,3,Bowel;Esophagus/Stomach;Uterus,-0.15886684453969094,-0.13767593603711412,0.0544042581405285,0.011386451645474928,0.5655533969194941,0.004619413145646955,0.1000806573681731,exploratory_cross_lineage_meta_analysis,0.05693225822737463 +ENTREZ:7157,ENTREZ:324,ENTREZ:441670,3,Bowel;Esophagus/Stomach;Uterus,-0.10406107624701437,-0.09411674989461329,0.029510121793108232,0.0014261580671195567,0.10907219911948639,0.0006469799914298144,0.3254893920577339,exploratory_cross_lineage_meta_analysis,0.009097904910935102 +ENTREZ:7157,ENTREZ:324,ENTREZ:85395,3,Bowel;Esophagus/Stomach;Uterus,-0.18026256730142404,-0.042994870040438005,0.12419718993872553,0.7292057087496928,0.792507084665148,0.035854198903888836,0.008071292419083035,exploratory_cross_lineage_meta_analysis,0.8327349143129208 +ENTREZ:7157,ENTREZ:324,ENTREZ:115572,3,Bowel;Esophagus/Stomach;Uterus,-0.11207808045896571,-0.078641688471266,0.0660110899915476,0.23351991985771892,0.8286704796248596,0.010581256515602287,0.002918440825579106,exploratory_cross_lineage_meta_analysis,0.5371117278986081 +ENTREZ:7157,ENTREZ:3845,ENTREZ:26269,5,Biliary Tract;Bowel;Esophagus/Stomach;Lung;Ovary/Fallopian Tube,-0.0618349422409371,-0.04228114850083246,0.031014427624270206,0.17279631828504038,0.7383218493445756,0.003142361388207378,0.004143437080870984,exploratory_cross_lineage_meta_analysis,0.44206579707107974 +ENTREZ:7157,ENTREZ:3845,ENTREZ:3845,5,Biliary Tract;Bowel;Esophagus/Stomach;Lung;Ovary/Fallopian Tube,-1.11980402486127,-1.11980402486127,0.10077612506429891,1.0992260405007512e-28,0.0,0.0,0.8682023742460336,exploratory_cross_lineage_meta_analysis,2.0335681749263894e-26 +ENTREZ:7157,ENTREZ:3845,ENTREZ:54545,5,Biliary Tract;Bowel;Esophagus/Stomach;Lung;Ovary/Fallopian Tube,-0.06815277437600764,-0.03398470057066631,0.02934260271131455,0.24678106416963075,0.7359379137351918,0.002952735568869515,0.004403988142604008,exploratory_cross_lineage_meta_analysis,0.5371117278986081 +ENTREZ:7157,ENTREZ:3845,ENTREZ:23168,5,Biliary Tract;Bowel;Esophagus/Stomach;Lung;Ovary/Fallopian Tube,-0.10713940264511565,-0.08568236845327243,0.029903058213237847,0.004165643764588828,0.3201338844728813,0.0014187360075388464,0.20801825385636538,exploratory_cross_lineage_meta_analysis,0.023289852127099685 +ENTREZ:7157,ENTREZ:3845,ENTREZ:54414,5,Biliary Tract;Bowel;Esophagus/Stomach;Lung;Ovary/Fallopian Tube,-0.040611487030551334,-0.009043775342027353,0.03247755964914067,0.7806575157874058,0.8503684412713819,0.004359548668806002,2.2515905904131976e-05,exploratory_cross_lineage_meta_analysis,0.8445709966121058 +ENTREZ:7157,ENTREZ:3845,ENTREZ:6484,5,Biliary Tract;Bowel;Esophagus/Stomach;Lung;Ovary/Fallopian Tube,-0.050367651299450936,-0.026462488327882804,0.04815901834142881,0.5826750756987771,0.8940830335391847,0.010014799667920595,1.2526113322055857e-07,exploratory_cross_lineage_meta_analysis,0.753810412617299 +ENTREZ:7157,ENTREZ:3845,ENTREZ:84773,5,Biliary Tract;Bowel;Esophagus/Stomach;Lung;Ovary/Fallopian Tube,-0.08896522101781379,-0.05258564639225241,0.07205679608763996,0.46552435123294966,0.9315050288883991,0.023532959869798083,6.294104528697728e-12,exploratory_cross_lineage_meta_analysis,0.7006281792666038 +ENTREZ:7157,ENTREZ:4089,ENTREZ:4084,4,Bowel;Esophagus/Stomach;Head and Neck;Pancreas,-0.058588815235404934,-0.04089581318782811,0.047569991117325836,0.3899556886387999,0.8453814269987899,0.007057713022866613,0.0002256921400006428,exploratory_cross_lineage_meta_analysis,0.6219120896394653 +ENTREZ:7157,ENTREZ:4893,ENTREZ:79705,3,Lymphoid;Myeloid;Skin,-0.14258440853583185,-0.03657008901411821,0.10779354718010387,0.7344135222044154,0.8354213729055978,0.028476907567408897,0.0022970648733398854,exploratory_cross_lineage_meta_analysis,0.8335368196798579 +ENTREZ:7157,ENTREZ:4893,ENTREZ:4893,3,Lymphoid;Myeloid;Skin,-1.3989681739906095,-1.3989681739906095,0.17298725809764715,6.109363701827543e-16,0.0,0.0,0.6960677744610329,exploratory_cross_lineage_meta_analysis,2.8255807120952384e-14 +ENTREZ:7157,ENTREZ:4893,ENTREZ:6197,3,Lymphoid;Myeloid;Skin,-0.2406087225243834,-0.1276687596216597,0.16127900605927872,0.4285928676704792,0.9221062307412322,0.07024015096330638,2.6578386386933816e-06,exploratory_cross_lineage_meta_analysis,0.6662998362944424 +ENTREZ:7157,ENTREZ:5290,ENTREZ:732,7,Bladder/Urinary Tract;Bowel;Breast;Esophagus/Stomach;Head and Neck;Ovary/Fallopian Tube;Uterus,-0.04733567538618562,-0.015227900642772957,0.032800657649262,0.642464376167736,0.8251121886520442,0.005981862972574049,5.866773238530247e-06,exploratory_cross_lineage_meta_analysis,0.7754374926847996 +ENTREZ:7157,ENTREZ:5290,ENTREZ:22943,7,Bladder/Urinary Tract;Bowel;Breast;Esophagus/Stomach;Head and Neck;Ovary/Fallopian Tube;Uterus,-0.049745783787742755,-0.01511308837600394,0.030022276505117535,0.6146860127674134,0.7048387480835555,0.003670359730859532,0.002420661816471309,exploratory_cross_lineage_meta_analysis,0.7735844378365407 +ENTREZ:7157,ENTREZ:5290,ENTREZ:343171,7,Bladder/Urinary Tract;Bowel;Breast;Esophagus/Stomach;Head and Neck;Ovary/Fallopian Tube;Uterus,-0.05443827459048173,-0.043557067593069564,0.015247176662755718,0.004280297147683186,0.23031510693140322,0.00036002277092661057,0.25347952414870956,exploratory_cross_lineage_meta_analysis,0.023289852127099685 +ENTREZ:7157,ENTREZ:5290,ENTREZ:5290,7,Bladder/Urinary Tract;Bowel;Breast;Esophagus/Stomach;Head and Neck;Ovary/Fallopian Tube;Uterus,-0.5375150299173711,-0.541063101645965,0.06396886594571828,2.7147646419597566e-17,0.057940061633691704,0.0017562103881026564,0.383145767373103,exploratory_cross_lineage_meta_analysis,1.6741048625418499e-15 +ENTREZ:7157,ENTREZ:5290,ENTREZ:10908,7,Bladder/Urinary Tract;Bowel;Breast;Esophagus/Stomach;Head and Neck;Ovary/Fallopian Tube;Uterus,-0.03806902628511737,0.0062680584232050595,0.04986116476996691,0.8999613048254852,0.9023028730543374,0.01499251225810202,2.321516484345674e-11,exploratory_cross_lineage_meta_analysis,0.9353530415321053 +ENTREZ:7157,ENTREZ:5290,ENTREZ:7799,7,Bladder/Urinary Tract;Bowel;Breast;Esophagus/Stomach;Head and Neck;Ovary/Fallopian Tube;Uterus,-0.03575739894767351,-0.013717133982291695,0.022518374630375475,0.5424230736665422,0.7788832882348847,0.0026122707833195445,0.00013661332232280823,exploratory_cross_lineage_meta_analysis,0.7219299901317289 +ENTREZ:7157,ENTREZ:53353,ENTREZ:285016,4,Bowel;Esophagus/Stomach;Lung;Uterus,-0.12067362757582774,-0.06713331477738277,0.04839561937704072,0.16538764155588304,0.7027148262436808,0.006248154948725455,0.017805615670240898,exploratory_cross_lineage_meta_analysis,0.44206579707107974 +ENTREZ:7157,ENTREZ:53353,ENTREZ:145853,4,Bowel;Esophagus/Stomach;Lung;Uterus,-0.08660495075932641,-0.02697863854230728,0.05277858392524309,0.609234546738811,0.8667794758043171,0.00849839517131368,5.0863298700102613e-05,exploratory_cross_lineage_meta_analysis,0.7735844378365407 +ENTREZ:7157,ENTREZ:53353,ENTREZ:23601,4,Bowel;Esophagus/Stomach;Lung;Uterus,-0.07581469917219821,-0.033160593772237665,0.03191097508955051,0.29873055015930905,0.7376685401854182,0.002671399971533745,0.009587821973710655,exploratory_cross_lineage_meta_analysis,0.5707443257036003 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+SYMBOL:ADAMTS7P1 (UNKNOWN),ADAMTS7P1 (Unknown),1,True,False,1177 +SYMBOL:ADCY10P1 (UNKNOWN),ADCY10P1 (Unknown),1,True,False,1177 +SYMBOL:ADGRL3-AS1 (UNKNOWN),ADGRL3-AS1 (Unknown),2,True,False,1176 +SYMBOL:ADIPOR1P2 (UNKNOWN),ADIPOR1P2 (Unknown),1,True,False,1177 +SYMBOL:AGA-DT (UNKNOWN),AGA-DT (Unknown),1,True,False,1177 +SYMBOL:AGAP11 (UNKNOWN),AGAP11 (Unknown),1,True,False,1177 +SYMBOL:AKAP17BP (UNKNOWN),AKAP17BP (Unknown),1,True,False,1177 +SYMBOL:AKR1B1P6 (UNKNOWN),AKR1B1P6 (Unknown),1,True,False,1177 +SYMBOL:AKR1C5P (UNKNOWN),AKR1C5P (Unknown),1,True,False,1177 +SYMBOL:AKR1C6P (UNKNOWN),AKR1C6P (Unknown),1,True,False,1177 +SYMBOL:AKR7L (UNKNOWN),AKR7L (Unknown),1,True,False,1177 +SYMBOL:ALMS1P1 (UNKNOWN),ALMS1P1 (Unknown),2,True,False,1176 +SYMBOL:ALOX15P2 (UNKNOWN),ALOX15P2 (Unknown),1,True,False,1177 +SYMBOL:ANKRD20A11P (UNKNOWN),ANKRD20A11P (Unknown),1,True,False,1177 +SYMBOL:ANKRD20A21P (UNKNOWN),ANKRD20A21P (Unknown),3,True,False,1175 +SYMBOL:ANKRD20A5P (UNKNOWN),ANKRD20A5P (Unknown),1,True,False,1177 +SYMBOL:ANKRD20A8P (UNKNOWN),ANKRD20A8P (Unknown),3,True,False,1175 +SYMBOL:ANKRD20A9P (UNKNOWN),ANKRD20A9P (Unknown),4,True,False,1174 +SYMBOL:ANKRD36BP2 (UNKNOWN),ANKRD36BP2 (Unknown),6,True,False,1172 +SYMBOL:ANKRD36P1 (UNKNOWN),ANKRD36P1 (Unknown),1,True,False,1177 +SYMBOL:ANTXRLP1 (UNKNOWN),ANTXRLP1 (Unknown),1,True,False,1177 +SYMBOL:ARNT2-DT (UNKNOWN),ARNT2-DT (Unknown),1,True,False,1177 +SYMBOL:ATP2B2-IT2 (UNKNOWN),ATP2B2-IT2 (Unknown),1,True,False,1177 +SYMBOL:ATP8A2P3 (UNKNOWN),ATP8A2P3 (Unknown),1,True,False,1177 +SYMBOL:ATXN8OS (UNKNOWN),ATXN8OS (Unknown),1,True,False,1177 +SYMBOL:AVPR1B-DT (UNKNOWN),AVPR1B-DT (Unknown),1,True,False,1177 +SYMBOL:B3GALT9 (UNKNOWN),B3GALT9 (Unknown),2,True,False,1176 +SYMBOL:BALR6 (UNKNOWN),BALR6 (Unknown),1,True,False,1177 +SYMBOL:BANCR (UNKNOWN),BANCR (Unknown),1,True,False,1177 +SYMBOL:BLACAT1 (UNKNOWN),BLACAT1 (Unknown),2,True,False,1176 +SYMBOL:BMS1P23 (UNKNOWN),BMS1P23 (Unknown),2,True,False,1176 +SYMBOL:BNIP3P32 (UNKNOWN),BNIP3P32 (Unknown),1,True,False,1177 +SYMBOL:BPIFB5P (UNKNOWN),BPIFB5P (Unknown),1,True,False,1177 +SYMBOL:BRPF3-AS1 (UNKNOWN),BRPF3-AS1 (Unknown),1,True,False,1177 +SYMBOL:BTG1-DT (UNKNOWN),BTG1-DT (Unknown),1,True,False,1177 +SYMBOL:C12ORF29P1 (UNKNOWN),C12orf29P1 (Unknown),1,True,False,1177 +SYMBOL:C12ORF29P3 (UNKNOWN),C12orf29P3 (Unknown),1,True,False,1177 +SYMBOL:C3P1 (UNKNOWN),C3P1 (Unknown),4,True,False,1174 +SYMBOL:C8ORF90 (UNKNOWN),C8orf90 (Unknown),1,True,False,1177 +SYMBOL:CALR4P (UNKNOWN),CALR4P (Unknown),1,True,False,1177 +SYMBOL:CASC15 (UNKNOWN),CASC15 (Unknown),3,True,False,1175 +SYMBOL:CASC6 (UNKNOWN),CASC6 (Unknown),1,True,False,1177 +SYMBOL:CASP1P1 (UNKNOWN),CASP1P1 (Unknown),1,True,False,1177 +SYMBOL:CASP1P2 (UNKNOWN),CASP1P2 (Unknown),1,True,False,1177 +SYMBOL:CASP4LP (UNKNOWN),CASP4LP (Unknown),2,True,False,1176 +SYMBOL:CBX1P3 (UNKNOWN),CBX1P3 (Unknown),1,True,False,1177 +SYMBOL:CCDC162P (UNKNOWN),CCDC162P (Unknown),4,True,False,1174 +SYMBOL:CCDC195 (UNKNOWN),CCDC195 (Unknown),2,True,False,1176 +SYMBOL:CCDC201 (UNKNOWN),CCDC201 (Unknown),1,True,False,1177 +SYMBOL:CCDC90B-AS1 (UNKNOWN),CCDC90B-AS1 (Unknown),2,True,False,1176 +SYMBOL:CCDC92B (UNKNOWN),CCDC92B (Unknown),2,True,False,1176 +SYMBOL:CCNYL2 (UNKNOWN),CCNYL2 (Unknown),2,True,False,1176 +SYMBOL:CCZ1P1 (UNKNOWN),CCZ1P1 (Unknown),1,True,False,1177 +SYMBOL:CEACAM22P (UNKNOWN),CEACAM22P (Unknown),1,True,False,1177 +SYMBOL:CEACAMP11 (UNKNOWN),CEACAMP11 (Unknown),1,True,False,1177 +SYMBOL:CENPIP1 (UNKNOWN),CENPIP1 (Unknown),2,True,False,1176 +SYMBOL:CES1P1 (UNKNOWN),CES1P1 (Unknown),2,True,False,1176 +SYMBOL:CES1P2 (UNKNOWN),CES1P2 (Unknown),1,True,False,1177 +SYMBOL:CFL1P1 (UNKNOWN),CFL1P1 (Unknown),15,True,False,1163 +SYMBOL:CHEK2P5 (UNKNOWN),CHEK2P5 (Unknown),1,True,False,1177 +SYMBOL:CHIAP2 (UNKNOWN),CHIAP2 (Unknown),3,True,False,1175 +SYMBOL:CLEC20A (UNKNOWN),CLEC20A (Unknown),3,True,False,1175 +SYMBOL:CLUHP10 (UNKNOWN),CLUHP10 (Unknown),1,True,False,1177 +SYMBOL:CMKLR2-AS (UNKNOWN),CMKLR2-AS (Unknown),3,True,False,1175 +SYMBOL:COL6A4P2 (UNKNOWN),COL6A4P2 (Unknown),4,True,False,1174 +SYMBOL:COMETT (UNKNOWN),COMETT (Unknown),1,True,False,1177 +SYMBOL:CPHXL2 (UNKNOWN),CPHXL2 (Unknown),1,True,False,1177 +SYMBOL:CRYGFP (UNKNOWN),CRYGFP (Unknown),1,True,False,1177 +SYMBOL:CSPG4BP (UNKNOWN),CSPG4BP (Unknown),1,True,False,1177 +SYMBOL:CST13P (UNKNOWN),CST13P (Unknown),1,True,False,1177 +SYMBOL:CSTP2 (UNKNOWN),CSTP2 (Unknown),1,True,False,1177 +SYMBOL:CT45A11P (UNKNOWN),CT45A11P (Unknown),1,True,False,1177 +SYMBOL:CT47C1 (UNKNOWN),CT47C1 (Unknown),1,True,False,1177 +SYMBOL:CT70 (UNKNOWN),CT70 (Unknown),1,True,False,1177 +SYMBOL:CUBNP2 (UNKNOWN),CUBNP2 (Unknown),2,True,False,1176 +SYMBOL:CUBNP3 (UNKNOWN),CUBNP3 (Unknown),1,True,False,1177 +SYMBOL:CXCL1P1 (UNKNOWN),CXCL1P1 (Unknown),1,True,False,1177 +SYMBOL:CYCSP48 (UNKNOWN),CYCSP48 (Unknown),2,True,False,1176 +SYMBOL:CYCTP (UNKNOWN),CYCTP (Unknown),1,True,False,1177 +SYMBOL:CYP2A7P2 (UNKNOWN),CYP2A7P2 (Unknown),1,True,False,1177 +SYMBOL:CYP2AB1P (UNKNOWN),CYP2AB1P (Unknown),1,True,False,1177 +SYMBOL:CYP2B7P (UNKNOWN),CYP2B7P (Unknown),2,True,False,1176 +SYMBOL:CYP2C58P (UNKNOWN),CYP2C58P (Unknown),1,True,False,1177 +SYMBOL:CYP4F23P (UNKNOWN),CYP4F23P (Unknown),1,True,False,1177 +SYMBOL:CYP4F29P (UNKNOWN),CYP4F29P (Unknown),2,True,False,1176 +SYMBOL:CYP4F9P (UNKNOWN),CYP4F9P (Unknown),2,True,False,1176 +SYMBOL:CYP4Z2P (UNKNOWN),CYP4Z2P (Unknown),2,True,False,1176 +SYMBOL:DDR1-DT (UNKNOWN),DDR1-DT (Unknown),1,True,False,1177 +SYMBOL:DLEC1P1 (UNKNOWN),DLEC1P1 (Unknown),3,True,False,1175 +SYMBOL:DNM1P35 (UNKNOWN),DNM1P35 (Unknown),1,True,False,1177 +SYMBOL:DPY19L1P1 (UNKNOWN),DPY19L1P1 (Unknown),1,True,False,1177 +SYMBOL:DPY19L1P2 (UNKNOWN),DPY19L1P2 (Unknown),2,True,False,1176 +SYMBOL:DPY19L2P2 (UNKNOWN),DPY19L2P2 (Unknown),2,True,False,1176 +SYMBOL:ECMXP (UNKNOWN),ECMXP (Unknown),3,True,False,1175 +SYMBOL:EGFEM1P (UNKNOWN),EGFEM1P (Unknown),2,True,False,1176 +SYMBOL:EIF1P2 (UNKNOWN),EIF1P2 (Unknown),2,True,False,1176 +SYMBOL:EIF1P5 (UNKNOWN),EIF1P5 (Unknown),1,True,False,1177 +SYMBOL:ELK2BP (UNKNOWN),ELK2BP (Unknown),1,True,False,1177 +SYMBOL:EMBP1 (UNKNOWN),EMBP1 (Unknown),3,True,False,1175 +SYMBOL:ENPP7P14 (UNKNOWN),ENPP7P14 (Unknown),2,True,False,1176 +SYMBOL:ENPP7P4 (UNKNOWN),ENPP7P4 (Unknown),1,True,False,1177 +SYMBOL:EXOC3L2 (UNKNOWN),EXOC3L2 (Unknown),4,True,False,1174 +SYMBOL:FAM174A-DT (UNKNOWN),FAM174A-DT (Unknown),1,True,False,1177 +SYMBOL:FAM240B (UNKNOWN),FAM240B (Unknown),1,True,False,1177 +SYMBOL:FAM242A (UNKNOWN),FAM242A (Unknown),2,True,False,1176 +SYMBOL:FAM246C (UNKNOWN),FAM246C (Unknown),1,True,False,1177 +SYMBOL:FAM66C (UNKNOWN),FAM66C (Unknown),1,True,False,1177 +SYMBOL:FAM86C1P (UNKNOWN),FAM86C1P (Unknown),1,True,False,1177 +SYMBOL:FAM86GP (UNKNOWN),FAM86GP (Unknown),14,True,False,1164 +SYMBOL:FAM86HP (UNKNOWN),FAM86HP (Unknown),1,True,False,1177 +SYMBOL:FANCD2P2 (UNKNOWN),FANCD2P2 (Unknown),1,True,False,1177 +SYMBOL:FBXL12P1 (UNKNOWN),FBXL12P1 (Unknown),1,True,False,1177 +SYMBOL:FCGR2C (UNKNOWN),FCGR2C (Unknown),1,True,False,1177 +SYMBOL:FCRL4P1 (UNKNOWN),FCRL4P1 (Unknown),2,True,False,1176 +SYMBOL:FER1L4 (UNKNOWN),FER1L4 (Unknown),1,True,False,1177 +SYMBOL:FLJ40288 (UNKNOWN),FLJ40288 (Unknown),1,True,False,1177 +SYMBOL:FLJ43315 (UNKNOWN),FLJ43315 (Unknown),1,True,False,1177 +SYMBOL:FMO11P (UNKNOWN),FMO11P (Unknown),1,True,False,1177 +SYMBOL:FMO8P (UNKNOWN),FMO8P (Unknown),1,True,False,1177 +SYMBOL:FMO9P (UNKNOWN),FMO9P (Unknown),1,True,False,1177 +SYMBOL:FOLH1B (UNKNOWN),FOLH1B (Unknown),2,True,False,1176 +SYMBOL:FRG1BP (UNKNOWN),FRG1BP (Unknown),4,True,False,1174 +SYMBOL:FRG1EP (UNKNOWN),FRG1EP (Unknown),1,True,False,1177 +SYMBOL:FRG1FP (UNKNOWN),FRG1FP (Unknown),1,True,False,1177 +SYMBOL:FRG1GP (UNKNOWN),FRG1GP (Unknown),5,True,False,1173 +SYMBOL:FRG2HP (UNKNOWN),FRG2HP (Unknown),1,True,False,1177 +SYMBOL:FSIP2LP (UNKNOWN),FSIP2LP (Unknown),2,True,False,1176 +SYMBOL:FTOP1 (UNKNOWN),FTOP1 (Unknown),5,True,False,1173 +SYMBOL:GAD3P (UNKNOWN),GAD3P (Unknown),1,True,False,1177 +SYMBOL:GEMIN2P1 (UNKNOWN),GEMIN2P1 (Unknown),3,True,False,1175 +SYMBOL:GGT4P (UNKNOWN),GGT4P (Unknown),2,True,False,1176 +SYMBOL:GGT8P (UNKNOWN),GGT8P (Unknown),1,True,False,1177 +SYMBOL:GGTA1 (UNKNOWN),GGTA1 (Unknown),3,True,False,1175 +SYMBOL:GIHCG (UNKNOWN),GIHCG (Unknown),1,True,False,1177 +SYMBOL:GOLGA2P5 (UNKNOWN),GOLGA2P5 (Unknown),1,True,False,1177 +SYMBOL:GOLGA2P8 (UNKNOWN),GOLGA2P8 (Unknown),1,True,False,1177 +SYMBOL:GOLGA2P9 (UNKNOWN),GOLGA2P9 (Unknown),3,True,False,1175 +SYMBOL:GREP1 (UNKNOWN),GREP1 (Unknown),1,True,False,1177 +SYMBOL:GS1-600G8.3 (UNKNOWN),GS1-600G8.3 (Unknown),1,True,False,1177 +SYMBOL:GSTA10P (UNKNOWN),GSTA10P (Unknown),1,True,False,1177 +SYMBOL:GTF2IRD1P1 (UNKNOWN),GTF2IRD1P1 (Unknown),1,True,False,1177 +SYMBOL:GUSBP1 (UNKNOWN),GUSBP1 (Unknown),1,True,False,1177 +SYMBOL:GUSBP10 (UNKNOWN),GUSBP10 (Unknown),1,True,False,1177 +SYMBOL:GUSBP12 (UNKNOWN),GUSBP12 (Unknown),1,True,False,1177 +SYMBOL:GUSBP6 (UNKNOWN),GUSBP6 (Unknown),1,True,False,1177 +SYMBOL:H2AL1Q (UNKNOWN),H2AL1Q (Unknown),2,True,False,1176 +SYMBOL:HAS2-AS1 (UNKNOWN),HAS2-AS1 (Unknown),1,True,False,1177 +SYMBOL:HCCS-DT (UNKNOWN),HCCS-DT (Unknown),1,True,False,1177 +SYMBOL:HERC2P10 (UNKNOWN),HERC2P10 (Unknown),1,True,False,1177 +SYMBOL:HLA-DRB6 (UNKNOWN),HLA-DRB6 (Unknown),4,True,False,1174 +SYMBOL:HLA-H (UNKNOWN),HLA-H (Unknown),3,True,False,1175 +SYMBOL:HLA-W (UNKNOWN),HLA-W (Unknown),1,True,False,1177 +SYMBOL:HMGB1P1 (UNKNOWN),HMGB1P1 (Unknown),3,True,False,1175 +SYMBOL:HMGN1P34 (UNKNOWN),HMGN1P34 (Unknown),1,True,False,1177 +SYMBOL:HNRNPA1P18 (UNKNOWN),HNRNPA1P18 (Unknown),1,True,False,1177 +SYMBOL:HNRNPA1P41 (UNKNOWN),HNRNPA1P41 (Unknown),4,True,False,1174 +SYMBOL:HNRNPCP8 (UNKNOWN),HNRNPCP8 (Unknown),2,True,False,1176 +SYMBOL:HNRNPD-DT (UNKNOWN),HNRNPD-DT (Unknown),1,True,False,1177 +SYMBOL:HOMEZ (UNKNOWN),HOMEZ (Unknown),1,True,False,1177 +SYMBOL:HRAT17 (UNKNOWN),HRAT17 (Unknown),1,True,False,1177 +SYMBOL:HSPD1P8 (UNKNOWN),HSPD1P8 (Unknown),2,True,False,1176 +SYMBOL:HSPE1P23 (UNKNOWN),HSPE1P23 (Unknown),1,True,False,1177 +SYMBOL:ID2-AS1 (UNKNOWN),ID2-AS1 (Unknown),1,True,False,1177 +SYMBOL:IFNL3P1 (UNKNOWN),IFNL3P1 (Unknown),1,True,False,1177 +SYMBOL:IGBP1C (UNKNOWN),IGBP1C (Unknown),2,True,False,1176 +SYMBOL:IGHA1 (UNKNOWN),IGHA1 (Unknown),3,True,False,1175 +SYMBOL:IGHA2 (UNKNOWN),IGHA2 (Unknown),4,True,False,1174 +SYMBOL:IGHD (UNKNOWN),IGHD (Unknown),8,True,False,1170 +SYMBOL:IGHD2-2 (UNKNOWN),IGHD2-2 (Unknown),1,True,False,1177 +SYMBOL:IGHE (UNKNOWN),IGHE (Unknown),5,True,False,1173 +SYMBOL:IGHG1 (UNKNOWN),IGHG1 (Unknown),3,True,False,1175 +SYMBOL:IGHG2 (UNKNOWN),IGHG2 (Unknown),3,True,False,1175 +SYMBOL:IGHG3 (UNKNOWN),IGHG3 (Unknown),6,True,False,1172 +SYMBOL:IGHJ1 (UNKNOWN),IGHJ1 (Unknown),1,True,False,1177 +SYMBOL:IGHM (UNKNOWN),IGHM (Unknown),5,True,False,1173 +SYMBOL:IGHV1-24 (UNKNOWN),IGHV1-24 (Unknown),1,True,False,1177 +SYMBOL:IGHV1-45 (UNKNOWN),IGHV1-45 (Unknown),1,True,False,1177 +SYMBOL:IGHV1-58 (UNKNOWN),IGHV1-58 (Unknown),1,True,False,1177 +SYMBOL:IGHV1-69 (UNKNOWN),IGHV1-69 (Unknown),1,True,False,1177 +SYMBOL:IGHV1OR21-1 (UNKNOWN),IGHV1OR21-1 (Unknown),4,True,False,1174 +SYMBOL:IGHV2-70 (UNKNOWN),IGHV2-70 (Unknown),1,True,False,1177 +SYMBOL:IGHV3-11 (UNKNOWN),IGHV3-11 (Unknown),1,True,False,1177 +SYMBOL:IGHV3-13 (UNKNOWN),IGHV3-13 (Unknown),1,True,False,1177 +SYMBOL:IGHV3-15 (UNKNOWN),IGHV3-15 (Unknown),2,True,False,1176 +SYMBOL:IGHV3-16 (UNKNOWN),IGHV3-16 (Unknown),3,True,False,1175 +SYMBOL:IGHV3-23 (UNKNOWN),IGHV3-23 (Unknown),3,True,False,1175 +SYMBOL:IGHV3-30 (UNKNOWN),IGHV3-30 (Unknown),1,True,False,1177 +SYMBOL:IGHV3-35 (UNKNOWN),IGHV3-35 (Unknown),1,True,False,1177 +SYMBOL:IGHV3-53 (UNKNOWN),IGHV3-53 (Unknown),1,True,False,1177 +SYMBOL:IGHV3-64 (UNKNOWN),IGHV3-64 (Unknown),2,True,False,1176 +SYMBOL:IGHV3-64D (UNKNOWN),IGHV3-64D (Unknown),4,True,False,1174 +SYMBOL:IGHV3-66 (UNKNOWN),IGHV3-66 (Unknown),3,True,False,1175 +SYMBOL:IGHV3-7 (UNKNOWN),IGHV3-7 (Unknown),1,True,False,1177 +SYMBOL:IGHV3-72 (UNKNOWN),IGHV3-72 (Unknown),2,True,False,1176 +SYMBOL:IGHV4-28 (UNKNOWN),IGHV4-28 (Unknown),1,True,False,1177 +SYMBOL:IGHV4-34 (UNKNOWN),IGHV4-34 (Unknown),4,True,False,1174 +SYMBOL:IGHV4-39 (UNKNOWN),IGHV4-39 (Unknown),2,True,False,1176 +SYMBOL:IGHV4-59 (UNKNOWN),IGHV4-59 (Unknown),2,True,False,1176 +SYMBOL:IGHV5-51 (UNKNOWN),IGHV5-51 (Unknown),1,True,False,1177 +SYMBOL:IGHV7-4-1 (UNKNOWN),IGHV7-4-1 (Unknown),3,True,False,1175 +SYMBOL:IGHV8-51-1 (UNKNOWN),IGHV8-51-1 (Unknown),3,True,False,1175 +SYMBOL:IGKJ1 (UNKNOWN),IGKJ1 (Unknown),2,True,False,1176 +SYMBOL:IGKJ3 (UNKNOWN),IGKJ3 (Unknown),1,True,False,1177 +SYMBOL:IGKV1-5 (UNKNOWN),IGKV1-5 (Unknown),2,True,False,1176 +SYMBOL:IGKV1-6 (UNKNOWN),IGKV1-6 (Unknown),3,True,False,1175 +SYMBOL:IGKV1-8 (UNKNOWN),IGKV1-8 (Unknown),1,True,False,1177 +SYMBOL:IGKV1D-43 (UNKNOWN),IGKV1D-43 (Unknown),2,True,False,1176 +SYMBOL:IGKV1D-8 (UNKNOWN),IGKV1D-8 (Unknown),1,True,False,1177 +SYMBOL:IGKV1OR22-1 (UNKNOWN),IGKV1OR22-1 (Unknown),1,True,False,1177 +SYMBOL:IGKV4-1 (UNKNOWN),IGKV4-1 (Unknown),1,True,False,1177 +SYMBOL:IGKV5-2 (UNKNOWN),IGKV5-2 (Unknown),1,True,False,1177 +SYMBOL:IGKV6D-41 (UNKNOWN),IGKV6D-41 (Unknown),1,True,False,1177 +SYMBOL:IGLC3 (UNKNOWN),IGLC3 (Unknown),2,True,False,1176 +SYMBOL:IGLJ6 (UNKNOWN),IGLJ6 (Unknown),1,True,False,1177 +SYMBOL:IGLV1-40 (UNKNOWN),IGLV1-40 (Unknown),2,True,False,1176 +SYMBOL:IGLV1-51 (UNKNOWN),IGLV1-51 (Unknown),1,True,False,1177 +SYMBOL:IGLV11-55 (UNKNOWN),IGLV11-55 (Unknown),1,True,False,1177 +SYMBOL:IGLV2-14 (UNKNOWN),IGLV2-14 (Unknown),2,True,False,1176 +SYMBOL:IGLV2-23 (UNKNOWN),IGLV2-23 (Unknown),3,True,False,1175 +SYMBOL:IGLV2-33 (UNKNOWN),IGLV2-33 (Unknown),1,True,False,1177 +SYMBOL:IGLV2-8 (UNKNOWN),IGLV2-8 (Unknown),1,True,False,1177 +SYMBOL:IGLV3-1 (UNKNOWN),IGLV3-1 (Unknown),1,True,False,1177 +SYMBOL:IGLV3-16 (UNKNOWN),IGLV3-16 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(Unknown),2,True,False,1176 +SYMBOL:TERLR1 (UNKNOWN),TERLR1 (Unknown),1,True,False,1177 +SYMBOL:THAP12P3 (UNKNOWN),THAP12P3 (Unknown),1,True,False,1177 +SYMBOL:THRAP3P1 (UNKNOWN),THRAP3P1 (Unknown),1,True,False,1177 +SYMBOL:TM9SF5P (UNKNOWN),TM9SF5P (Unknown),1,True,False,1177 +SYMBOL:TMEM231P1 (UNKNOWN),TMEM231P1 (Unknown),1,True,False,1177 +SYMBOL:TMEM238L (UNKNOWN),TMEM238L (Unknown),4,True,False,1174 +SYMBOL:TMEM254-AS1 (UNKNOWN),TMEM254-AS1 (Unknown),1,True,False,1177 +SYMBOL:TPM3P2 (UNKNOWN),TPM3P2 (Unknown),1,True,False,1177 +SYMBOL:TPRX2 (UNKNOWN),TPRX2 (Unknown),2,True,False,1176 +SYMBOL:TPSP2 (UNKNOWN),TPSP2 (Unknown),1,True,False,1177 +SYMBOL:TPTE2P1 (UNKNOWN),TPTE2P1 (Unknown),1,True,False,1177 +SYMBOL:TPTE2P6 (UNKNOWN),TPTE2P6 (Unknown),1,True,False,1177 +SYMBOL:TRAJ10 (UNKNOWN),TRAJ10 (Unknown),1,True,False,1177 +SYMBOL:TRAJ17 (UNKNOWN),TRAJ17 (Unknown),1,True,False,1177 +SYMBOL:TRAJ35 (UNKNOWN),TRAJ35 (Unknown),1,True,False,1177 +SYMBOL:TRAJ48 (UNKNOWN),TRAJ48 (Unknown),1,True,False,1177 +SYMBOL:TRAJ56 (UNKNOWN),TRAJ56 (Unknown),1,True,False,1177 +SYMBOL:TRAV1-1 (UNKNOWN),TRAV1-1 (Unknown),3,True,False,1175 +SYMBOL:TRAV1-2 (UNKNOWN),TRAV1-2 (Unknown),1,True,False,1177 +SYMBOL:TRAV10 (UNKNOWN),TRAV10 (Unknown),2,True,False,1176 +SYMBOL:TRAV12-3 (UNKNOWN),TRAV12-3 (Unknown),1,True,False,1177 +SYMBOL:TRAV13-1 (UNKNOWN),TRAV13-1 (Unknown),1,True,False,1177 +SYMBOL:TRAV13-2 (UNKNOWN),TRAV13-2 (Unknown),1,True,False,1177 +SYMBOL:TRAV2 (UNKNOWN),TRAV2 (Unknown),1,True,False,1177 +SYMBOL:TRAV20 (UNKNOWN),TRAV20 (Unknown),1,True,False,1177 +SYMBOL:TRAV22 (UNKNOWN),TRAV22 (Unknown),3,True,False,1175 +SYMBOL:TRAV25 (UNKNOWN),TRAV25 (Unknown),3,True,False,1175 +SYMBOL:TRAV27 (UNKNOWN),TRAV27 (Unknown),1,True,False,1177 +SYMBOL:TRAV3 (UNKNOWN),TRAV3 (Unknown),2,True,False,1176 +SYMBOL:TRAV36DV7 (UNKNOWN),TRAV36DV7 (Unknown),2,True,False,1176 +SYMBOL:TRAV38-1 (UNKNOWN),TRAV38-1 (Unknown),1,True,False,1177 +SYMBOL:TRAV38-2DV8 (UNKNOWN),TRAV38-2DV8 (Unknown),1,True,False,1177 +SYMBOL:TRAV40 (UNKNOWN),TRAV40 (Unknown),1,True,False,1177 +SYMBOL:TRAV6 (UNKNOWN),TRAV6 (Unknown),2,True,False,1176 +SYMBOL:TRAV7 (UNKNOWN),TRAV7 (Unknown),1,True,False,1177 +SYMBOL:TRAV8-2 (UNKNOWN),TRAV8-2 (Unknown),2,True,False,1176 +SYMBOL:TRAV8-4 (UNKNOWN),TRAV8-4 (Unknown),2,True,False,1176 +SYMBOL:TRAV8-6 (UNKNOWN),TRAV8-6 (Unknown),1,True,False,1177 +SYMBOL:TRAV8-7 (UNKNOWN),TRAV8-7 (Unknown),2,True,False,1176 +SYMBOL:TRAV9-1 (UNKNOWN),TRAV9-1 (Unknown),1,True,False,1177 +SYMBOL:TRAV9-2 (UNKNOWN),TRAV9-2 (Unknown),2,True,False,1176 +SYMBOL:TRBC1 (UNKNOWN),TRBC1 (Unknown),1,True,False,1177 +SYMBOL:TRBC2 (UNKNOWN),TRBC2 (Unknown),1,True,False,1177 +SYMBOL:TRBD1 (UNKNOWN),TRBD1 (Unknown),1,True,False,1177 +SYMBOL:TRBV10-1 (UNKNOWN),TRBV10-1 (Unknown),6,True,False,1172 +SYMBOL:TRBV11-1 (UNKNOWN),TRBV11-1 (Unknown),1,True,False,1177 +SYMBOL:TRBV11-3 (UNKNOWN),TRBV11-3 (Unknown),4,True,False,1174 +SYMBOL:TRBV12-3 (UNKNOWN),TRBV12-3 (Unknown),1,True,False,1177 +SYMBOL:TRBV12-4 (UNKNOWN),TRBV12-4 (Unknown),2,True,False,1176 +SYMBOL:TRBV12-5 (UNKNOWN),TRBV12-5 (Unknown),1,True,False,1177 +SYMBOL:TRBV13 (UNKNOWN),TRBV13 (Unknown),1,True,False,1177 +SYMBOL:TRBV14 (UNKNOWN),TRBV14 (Unknown),2,True,False,1176 +SYMBOL:TRBV15 (UNKNOWN),TRBV15 (Unknown),3,True,False,1175 +SYMBOL:TRBV17 (UNKNOWN),TRBV17 (Unknown),1,True,False,1177 +SYMBOL:TRBV18 (UNKNOWN),TRBV18 (Unknown),1,True,False,1177 +SYMBOL:TRBV19 (UNKNOWN),TRBV19 (Unknown),1,True,False,1177 +SYMBOL:TRBV20-1 (UNKNOWN),TRBV20-1 (Unknown),2,True,False,1176 +SYMBOL:TRBV20OR9-2 (UNKNOWN),TRBV20OR9-2 (Unknown),2,True,False,1176 +SYMBOL:TRBV23-1 (UNKNOWN),TRBV23-1 (Unknown),2,True,False,1176 +SYMBOL:TRBV24-1 (UNKNOWN),TRBV24-1 (Unknown),2,True,False,1176 +SYMBOL:TRBV25-1 (UNKNOWN),TRBV25-1 (Unknown),1,True,False,1177 +SYMBOL:TRBV27 (UNKNOWN),TRBV27 (Unknown),2,True,False,1176 +SYMBOL:TRBV29-1 (UNKNOWN),TRBV29-1 (Unknown),1,True,False,1177 +SYMBOL:TRBV3-1 (UNKNOWN),TRBV3-1 (Unknown),2,True,False,1176 +SYMBOL:TRBV4-1 (UNKNOWN),TRBV4-1 (Unknown),2,True,False,1176 +SYMBOL:TRBV5-1 (UNKNOWN),TRBV5-1 (Unknown),2,True,False,1176 +SYMBOL:TRBV5-3 (UNKNOWN),TRBV5-3 (Unknown),1,True,False,1177 +SYMBOL:TRBV5-4 (UNKNOWN),TRBV5-4 (Unknown),1,True,False,1177 +SYMBOL:TRBV5-5 (UNKNOWN),TRBV5-5 (Unknown),1,True,False,1177 +SYMBOL:TRBV6-2 (UNKNOWN),TRBV6-2 (Unknown),1,True,False,1177 +SYMBOL:TRBV6-4 (UNKNOWN),TRBV6-4 (Unknown),2,True,False,1176 +SYMBOL:TRBV6-6 (UNKNOWN),TRBV6-6 (Unknown),1,True,False,1177 +SYMBOL:TRBV6-8 (UNKNOWN),TRBV6-8 (Unknown),1,True,False,1177 +SYMBOL:TRBV7-1 (UNKNOWN),TRBV7-1 (Unknown),1,True,False,1177 +SYMBOL:TRBV7-2 (UNKNOWN),TRBV7-2 (Unknown),1,True,False,1177 +SYMBOL:TRBV7-3 (UNKNOWN),TRBV7-3 (Unknown),1,True,False,1177 +SYMBOL:TRBV7-6 (UNKNOWN),TRBV7-6 (Unknown),2,True,False,1176 +SYMBOL:TRBV7-7 (UNKNOWN),TRBV7-7 (Unknown),1,True,False,1177 +SYMBOL:TRDV1 (UNKNOWN),TRDV1 (Unknown),4,True,False,1174 +SYMBOL:TRDV2 (UNKNOWN),TRDV2 (Unknown),1,True,False,1177 +SYMBOL:TREHP1 (UNKNOWN),TREHP1 (Unknown),1,True,False,1177 +SYMBOL:TREML5P (UNKNOWN),TREML5P (Unknown),1,True,False,1177 +SYMBOL:TRGC2 (UNKNOWN),TRGC2 (Unknown),3,True,False,1175 +SYMBOL:TRGJ2 (UNKNOWN),TRGJ2 (Unknown),2,True,False,1176 +SYMBOL:TRGV1 (UNKNOWN),TRGV1 (Unknown),1,True,False,1177 +SYMBOL:TRGV11 (UNKNOWN),TRGV11 (Unknown),2,True,False,1176 +SYMBOL:TRGV5 (UNKNOWN),TRGV5 (Unknown),1,True,False,1177 +SYMBOL:TRGV8 (UNKNOWN),TRGV8 (Unknown),1,True,False,1177 +SYMBOL:TRGV9 (UNKNOWN),TRGV9 (Unknown),2,True,False,1176 +SYMBOL:TRHDE-AS1 (UNKNOWN),TRHDE-AS1 (Unknown),1,True,False,1177 +SYMBOL:TRIM51DP (UNKNOWN),TRIM51DP (Unknown),1,True,False,1177 +SYMBOL:TRIM51FP (UNKNOWN),TRIM51FP (Unknown),1,True,False,1177 +SYMBOL:TRIM51G (UNKNOWN),TRIM51G (Unknown),3,True,False,1175 +SYMBOL:TRIM64FP (UNKNOWN),TRIM64FP (Unknown),4,True,False,1174 +SYMBOL:TRIM75 (UNKNOWN),TRIM75 (Unknown),3,True,False,1175 +SYMBOL:TRIM77BP (UNKNOWN),TRIM77BP (Unknown),1,True,False,1177 +SYMBOL:TRMT1P1 (UNKNOWN),TRMT1P1 (Unknown),1,True,False,1177 +SYMBOL:TUNAR (UNKNOWN),TUNAR (Unknown),1,True,False,1177 +SYMBOL:UBTFL8 (UNKNOWN),UBTFL8 (Unknown),1,True,False,1177 +SYMBOL:UGT1A3 (UNKNOWN),UGT1A3 (Unknown),1,True,False,1177 +SYMBOL:UGT1A5 (UNKNOWN),UGT1A5 (Unknown),1,True,False,1177 +SYMBOL:UGT2B24P (UNKNOWN),UGT2B24P (Unknown),4,True,False,1174 +SYMBOL:USP24P1 (UNKNOWN),USP24P1 (Unknown),2,True,False,1176 +SYMBOL:VASH1-DT (UNKNOWN),VASH1-DT (Unknown),1,True,False,1177 +SYMBOL:VINAC1P (UNKNOWN),VINAC1P (Unknown),1,True,False,1177 +SYMBOL:VN1R9P (UNKNOWN),VN1R9P (Unknown),1,True,False,1177 +SYMBOL:VOPP1-DT (UNKNOWN),VOPP1-DT (Unknown),2,True,False,1176 +SYMBOL:WARS1P1 (UNKNOWN),WARS1P1 (Unknown),1,True,False,1177 +SYMBOL:WDR4P2 (UNKNOWN),WDR4P2 (Unknown),1,True,False,1177 +SYMBOL:WDR95P (UNKNOWN),WDR95P (Unknown),3,True,False,1175 +SYMBOL:XACT (UNKNOWN),XACT (Unknown),1,True,False,1177 +SYMBOL:XNDC1CP (UNKNOWN),XNDC1CP (Unknown),1,True,False,1177 +SYMBOL:YWHAEP7 (UNKNOWN),YWHAEP7 (Unknown),1,True,False,1177 +SYMBOL:ZACNP1 (UNKNOWN),ZACNP1 (Unknown),1,True,False,1177 +SYMBOL:ZCCHC10P1 (UNKNOWN),ZCCHC10P1 (Unknown),1,True,False,1177 +SYMBOL:ZNF209P (UNKNOWN),ZNF209P (Unknown),2,True,False,1176 +SYMBOL:ZNF722 (UNKNOWN),ZNF722 (Unknown),8,True,False,1170 +SYMBOL:ZNF736P9Y (UNKNOWN),ZNF736P9Y (Unknown),1,True,False,1177 +SYMBOL:ZNF781 (UNKNOWN),ZNF781 (Unknown),2,True,True,0 +SYMBOL:ZNF847P (UNKNOWN),ZNF847P (Unknown),1,True,False,1177 +SYMBOL:ZNF861P (UNKNOWN),ZNF861P (Unknown),1,True,False,1177 +SYMBOL:ZNF883 (UNKNOWN),ZNF883 (Unknown),1,True,False,1177 +SYMBOL:ZNF892 (UNKNOWN),ZNF892 (Unknown),1,True,False,1177 +SYMBOL:ZNF92P2 (UNKNOWN),ZNF92P2 (Unknown),9,True,False,1169 +SYMBOL:ZNF969P (UNKNOWN),ZNF969P (Unknown),1,True,False,1177 diff --git a/results/Main_C1_C2/hypothesis_catalogue.csv b/results/Main_C1_C2/hypothesis_catalogue.csv new file mode 100644 index 0000000000000000000000000000000000000000..f1fb79e589793fff65852c14a078f7141003bf8c --- /dev/null +++ b/results/Main_C1_C2/hypothesis_catalogue.csv @@ -0,0 +1,547 @@ +A,B,A_symbol,B_symbol,gene,gene_symbol,Scope,Lineage,inferential_tier,primary_pan_cancer_signal,beta,ci_low,ci_high,q_global_BH,q_global_BY,q_pair_BH,evidence_classification,validation_status,holdout_status,independent_experimental_validation,pathway_support,molecular_support,hypothesis,alternatives,falsifiable_test,human_review +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:3845,KRAS,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-1.0865308434948422,-1.2522251612858322,-0.9208365257038522,5.879271802588757e-24,1.053430644354516e-22,5.956436323901878e-24,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,internally_replicated,False,not established,expression: delta 0.293 (unadjusted contrast; not causal); copy_number: delta 0.145 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on KRAS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KRAS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ENTREZ:673,BRAF,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-1.0910946187228885,-1.3059463059620786,-0.8762429314836979,4.69782143761724e-09,8.417418398503914e-08,4.725210079663258e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: rRNA processing in the nucleus and cytosol (FDR=0.0311); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0311); GSEA: p75NTR recruits signalling complexes (FDR=0.0311),expression: delta 0.237 (unadjusted contrast; not causal); copy_number: delta 0.333 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in BRAF is associated with stronger CRISPR dependency on BRAF; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BRAF with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ENTREZ:5290,PIK3CA,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.6206702665037973,-0.764523569013355,-0.4768169639942395,4.967113146706839e-09,8.899927369258888e-08,4.996071779082237e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,not established,expression: delta -0.000685 (unadjusted contrast; not causal); copy_number: delta 0.197 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PIK3CA is associated with stronger CRISPR dependency on PIK3CA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PIK3CA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ENTREZ:4893,NRAS,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-1.3350632067960593,-1.644736244111744,-1.0253901694803746,3.7195541842699805e-08,6.664587881992054e-07,3.741239456789707e-08,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.479 (unadjusted contrast; not causal); copy_number: delta 0.0962 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NRAS is associated with stronger CRISPR dependency on NRAS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NRAS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ENTREZ:9124,PDLIM1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1422393479163315,-0.1758924694970843,-0.1085862263355787,8.760532046773025e-08,1.5696863878375136e-06,8.811606588355312e-08,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.485 (unadjusted contrast; not causal); copy_number: delta -0.0174 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ATRX is associated with stronger CRISPR dependency on PDLIM1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PDLIM1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ENTREZ:673,BRAF,within_lineage,Skin,precision_eligible,False,-1.1788788245383204,-1.3727434830189689,-0.985014166057672,9.63256426730532e-08,1.605871613461223e-06,1.2795807582824207e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: GP1b-IX-V activation signalling (FDR=0.0321); GSEA: GLI3 is processed to GLI3R by the proteasome (FDR=0.0321); GSEA: GAB1 signalosome (FDR=0.0321),expression: delta 0.364 (unadjusted contrast; not causal); copy_number: delta 0.442 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in BRAF is associated with stronger CRISPR dependency on BRAF; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BRAF with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:85016,CFAP300,within_lineage,Lung,precision_eligible,False,-0.1411363983594159,-0.1717430005712904,-0.1105297961475414,9.63256426730532e-08,1.605871613461223e-06,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.29 (unadjusted contrast; not causal); copy_number: delta -0.0252 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on CFAP300; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CFAP300 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:390999,PRAMEF12,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2093218233136288,-0.2573433505535891,-0.1613002960736686,1.0924077748988593e-07,1.95734414881598e-06,1.0987765920010625e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00607 (unadjusted contrast; not causal); copy_number: delta 0.0783 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on PRAMEF12; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRAMEF12 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:283078,MKX,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1815025660300815,-0.2238257807826812,-0.1391793512774818,2.0878360626101844e-07,3.740923302395388e-06,1.0987765920010625e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0185 (unadjusted contrast; not causal); copy_number: delta -0.0854 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on MKX; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MKX with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:23601,CLEC5A,within_lineage,Lung,precision_eligible,False,-0.0894285800846196,-0.1097476660331033,-0.0691094941361359,4.955871432268486e-07,8.262071274266972e-06,4.767316068721396e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00196 (unadjusted contrast; not causal); copy_number: delta 0.133 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on CLEC5A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CLEC5A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:83901,KRTAP9-8,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1076127681410301,-0.1331394269953507,-0.0820861092867095,8.544204783378155e-07,1.5309255044966268e-05,9.322218911980652e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00429 (unadjusted contrast; not causal); copy_number: delta 0.053 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on KRTAP9-8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KRTAP9-8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ENTREZ:84320,ACBD6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1210771384124408,-0.1500965894435448,-0.0920576873813368,1.1634344867715906e-06,2.084607723909631e-05,1.2538043515616061e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.153 (unadjusted contrast; not causal); copy_number: delta -0.0643 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CNTNAP2 is associated with stronger CRISPR dependency on ACBD6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ACBD6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:146325,PRR35,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1507807162573974,-0.1884474722445955,-0.1131139602701992,1.907526625860979e-06,3.417850152325546e-05,2.0614001215747637e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0344 (unadjusted contrast; not causal); copy_number: delta 0.0827 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on PRR35; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRR35 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:1719,DHFR,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.5396753485849619,-0.6720859290680695,-0.4072647681018543,2.285319876341801e-06,4.0947689964442364e-05,9.322218911980652e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.332 (unadjusted contrast; not causal); copy_number: delta 0.0111 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on DHFR; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DHFR with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:51084,CRYL1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.135267586461926,-0.1693383369638837,-0.1011968359599683,2.285319876341801e-06,4.0947689964442364e-05,2.587704264232238e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.407 (unadjusted contrast; not causal); copy_number: delta -0.0842 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on CRYL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CRYL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:7555,CNBP,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3940936007462384,-0.4814582233113972,-0.3067289781810796,2.8142476504732347e-06,5.042486238696814e-05,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0494 (unadjusted contrast; not causal); copy_number: delta 0.0574 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on CNBP; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CNBP with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:84885,ZDHHC12,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.08191342192341,-0.1029739073539125,-0.0608529364929074,4.1181547544376185e-06,7.378788670067345e-05,4.502263395179459e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.000543 (unadjusted contrast; not causal); copy_number: delta 0.0484 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on ZDHHC12; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZDHHC12 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:1796,DOK1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1548810330665694,-0.1953283003201801,-0.1144337658129587,5.065154058668074e-06,9.075594194213218e-05,2.5311773649289936e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.27 (unadjusted contrast; not causal); copy_number: delta 0.0245 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on DOK1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DOK1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:5479,PPIB,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2400078629565078,-0.2952151213730653,-0.1848006045399503,7.159388068431095e-06,0.00012827981150302574,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.347 (unadjusted contrast; not causal); copy_number: delta 0.0193 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on PPIB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPIB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:54626,HES2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1669111320160176,-0.2060556461970989,-0.1277666178349363,1.2458286677412371e-05,0.00022322391960788527,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.462 (unadjusted contrast; not causal); copy_number: delta -0.105 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on HES2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HES2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:84773,TMEM276,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.2426519282976816,-0.2975092951706348,-0.1877945614247284,1.7435057576459196e-05,0.0002906647001165593,2.350672500648786e-05,multiplicity_robust_exploratory_statistical_hypothesis,unavailable,holdout_underpowered,False,not established,not established,"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on TMEM276; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TMEM276 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:9218,VAPA,within_lineage,Lung,precision_eligible,False,-0.2262761510258059,-0.2840676342234856,-0.1684846678281263,1.8663154823368848e-05,0.0003111386513164073,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.252 (unadjusted contrast; not causal); copy_number: delta -0.0594 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on VAPA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb VAPA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:145853,C15orf61,within_lineage,Lung,precision_eligible,False,-0.1302111895857998,-0.163656977460717,-0.0967654017108826,2.054870697849821e-05,0.0003425732163771388,4.767316068721396e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.252 (unadjusted contrast; not causal); copy_number: delta -0.0849 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on C15orf61; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C15orf61 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7015,TP53,TERT,ENTREZ:7813,EVI5,within_lineage,Lung,precision_eligible,False,-0.1365319841916248,-0.1718854379053745,-0.101178530477875,2.3464800741107e-05,0.00039118822755811075,3.5132444408333763e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.422 (unadjusted contrast; not causal); copy_number: delta -0.0418 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TERT is associated with stronger CRISPR dependency on EVI5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb EVI5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8289,TP53,ARID1A,ENTREZ:10276,NET1,within_lineage,Bowel,precision_eligible,False,-0.1843520332677647,-0.2241479341607382,-0.1445561323747911,2.405480063739038e-05,0.0004010242801303465,3.5132444408333763e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.445 (unadjusted contrast; not causal); copy_number: delta 0.0751 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ARID1A is associated with stronger CRISPR dependency on NET1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NET1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:4184,SMCP,within_lineage,Lung,precision_eligible,False,-0.0947357963429512,-0.1194565153348706,-0.0700150773510318,2.551908780091681e-05,0.00042543581920353004,4.767316068721396e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0188 (unadjusted contrast; not causal); copy_number: delta 0.112 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on SMCP; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SMCP with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:25841,ABTB2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1567665833091063,-0.1995714712936455,-0.1139616953245671,4.2733129333483226e-05,0.0007656796535454359,9.322218911980652e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.12 (unadjusted contrast; not causal); copy_number: delta -0.047 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on ABTB2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ABTB2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ENTREZ:7071,KLF10,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2761298509541908,-0.3399501983563369,-0.2123095035520447,6.938531924577752e-05,0.0012432257601977018,9.720727815119711e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.464 (unadjusted contrast; not causal); copy_number: delta -0.138 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in KIF20B is associated with stronger CRISPR dependency on KLF10; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KLF10 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ENTREZ:341799,OR6S1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1479065712039866,-0.1885292098312795,-0.1072839325766936,7.512539793792793e-05,0.0013460748033845657,0.0001041167154611385,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0043 (unadjusted contrast; not causal); copy_number: delta 0.0687 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KCNT2 is associated with stronger CRISPR dependency on OR6S1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR6S1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ENTREZ:152404,IGSF11,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1153289367380744,-0.1481119928356621,-0.0825458806404866,7.926387748537591e-05,0.0014202268637536152,3.5036725300167764e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.309 (unadjusted contrast; not causal); copy_number: delta 0.00242 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PPP1R9A is associated with stronger CRISPR dependency on IGSF11; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb IGSF11 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:50859,SPOCK3,within_lineage,Lung,precision_eligible,False,-0.1449939034025035,-0.184557973728488,-0.105429833076519,8.911057017384361e-05,0.0014855871305964469,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0644 (unadjusted contrast; not causal); copy_number: delta -0.0215 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on SPOCK3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SPOCK3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:154664,TP53,ABCA13,ENTREZ:9530,BAG4,within_lineage,Lung,precision_eligible,False,-0.1176406803242677,-0.1498114121264442,-0.0854699485220912,8.911057017384361e-05,0.0014855871305964469,3.5132444408333763e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.127 (unadjusted contrast; not causal); copy_number: delta -0.185 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCA13 is associated with stronger CRISPR dependency on BAG4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BAG4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:7157,TP53,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.6690480767468656,-0.858806449096913,-0.4792897043968183,9.569818600707281e-05,0.0017146919743462076,4.996071779082237e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,"ORA: p53-Dependent G1/S DNA damage checkpoint (FDR=1.92e-06); ORA: p53-Dependent G1 DNA Damage Response (FDR=1.92e-06); ORA: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (FDR=2e-06); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0413); GSEA: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (FDR=0.0413); GSEA: Vpu mediated degradation of CD4 (FDR=0.0413)",expression: delta -0.0177 (unadjusted contrast; not causal); copy_number: delta -0.00139 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on TP53; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TP53 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ENTREZ:79944,L2HGDH,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1757264475669163,-0.2256644154223527,-0.1257884797114798,9.669673085231688e-05,0.0017325836074440204,0.0001041167154611385,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.427 (unadjusted contrast; not causal); copy_number: delta -0.052 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNA2 is associated with stronger CRISPR dependency on L2HGDH; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb L2HGDH with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:8514,KCNAB2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1505584871536661,-0.1932362106260924,-0.1078807636812397,0.0001288374468397344,0.0023084715114142433,1.0987765920010625e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.447 (unadjusted contrast; not causal); copy_number: delta 0.273 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on KCNAB2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KCNAB2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ENTREZ:8387,OR1E1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1654319972269921,-0.2124151654817253,-0.1184488289722588,0.0001293915322444478,0.0023183994508685422,0.0001041167154611385,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0111 (unadjusted contrast; not causal); copy_number: delta -0.0654 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNA2 is associated with stronger CRISPR dependency on OR1E1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR1E1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ENTREZ:4744,NEFH,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1811065538630737,-0.2327279271638489,-0.1294851805622985,0.0001377951991180705,0.0024689738843506445,0.0001041167154611385,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.357 (unadjusted contrast; not causal); copy_number: delta -0.0198 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KCNT2 is associated with stronger CRISPR dependency on NEFH; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NEFH with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4780,TP53,NFE2L2,ENTREZ:10361,NPM2,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1035860671902149,-0.1299296366888932,-0.0772424976915366,0.00016759383782566722,0.0027940035413908763,0.0003177466147393907,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Sema4D in semaphorin signaling (FDR=0.0395); GSEA: Signaling by VEGF (FDR=0.0395); GSEA: Phase I - Functionalization of compounds (FDR=0.0395),expression: delta -0.498 (unadjusted contrast; not causal); copy_number: delta 0.0471 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NFE2L2 is associated with stronger CRISPR dependency on NPM2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NPM2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:284297,SSC5D,within_lineage,Lung,precision_eligible,False,-0.1418754388565158,-0.1817839331781634,-0.1019669445348682,0.00017357492504770983,0.0028937159120637048,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0637 (unadjusted contrast; not causal); copy_number: delta 0.0621 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on SSC5D; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SSC5D with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:10046,MAMLD1,within_lineage,Bowel,precision_eligible,False,-0.279969087534999,-0.3387737755883981,-0.2211643994815999,0.000178710662958259,0.0029793352289544366,0.0003177466147393907,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.528 (unadjusted contrast; not causal); copy_number: delta -0.196 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on MAMLD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAMLD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ENTREZ:9311,ASIC3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0915714228989641,-0.1174687861779864,-0.0656740596199419,0.00016663173677616814,0.0029856584920047316,0.00027113314749751654,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 1.02 (unadjusted contrast; not causal); copy_number: delta -0.0457 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRRIQ3 is associated with stronger CRISPR dependency on ASIC3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ASIC3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:181,AGRP,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1536190146750028,-0.1936268669546741,-0.1136111623953316,0.00016942122187537054,0.003035639666274923,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0126 (unadjusted contrast; not causal); copy_number: delta 0.00353 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on AGRP; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AGRP with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:84107,ZIC4,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0963033106393844,-0.1241514085119803,-0.0684552127667884,0.00016942122187537054,0.003035639666274923,4.502263395179459e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.119 (unadjusted contrast; not causal); copy_number: delta -0.109 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on ZIC4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZIC4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ENTREZ:7157,TP53,within_lineage,Skin,precision_eligible,False,-0.8569077390316492,-1.0602864303286224,-0.653529047734676,0.00018604973907735778,0.0031016870106985194,0.0003177466147393907,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.3 (unadjusted contrast; not causal); copy_number: delta 0.0444 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on TP53; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TP53 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:8085,APC,KMT2D,ENTREZ:5204,PFDN5,within_lineage,Bowel,precision_eligible,False,-0.5257261101269709,-0.6527280213687094,-0.3987241988852323,0.00018604973907735778,0.0031016870106985194,0.0003177466147393907,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.223 (unadjusted contrast; not causal); copy_number: delta 0.0148 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on PFDN5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PFDN5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:50674,NEUROG3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1188177004811183,-0.1532583462557517,-0.0843770547064849,0.00017921256840360326,0.003211078136015221,2.0614001215747637e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0647 (unadjusted contrast; not causal); copy_number: delta 0.0246 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on NEUROG3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NEUROG3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:7157,TP53,within_lineage,Skin,precision_eligible,False,-0.8069694294639461,-1.0020976575475726,-0.6118412013803195,0.0002066444322941773,0.0034450268764608144,1.9536731784932713e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (FDR=0.0376); GSEA: PCP/CE pathway (FDR=0.0376); GSEA: Activation of NF-kappaB in B cells (FDR=0.0376),expression: delta -0.0767 (unadjusted contrast; not causal); copy_number: delta -0.123 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on TP53; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TP53 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:23345,KRAS,SYNE1,ENTREZ:55291,PPP6R3,within_lineage,Bowel,precision_eligible,False,-0.5131958432361029,-0.6229953643774189,-0.4033963220947869,0.0002066444322941773,0.0034450268764608144,0.0003772536524379831,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.288 (unadjusted contrast; not causal); copy_number: delta 0.0349 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on PPP6R3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPP6R3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:23648,SSBP3,within_lineage,Lung,precision_eligible,False,-0.259236766287464,-0.3332007552834191,-0.1852727772915088,0.0002066444322941773,0.0034450268764608144,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 1.67 (unadjusted contrast; not causal); copy_number: delta 0.00813 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on SSBP3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SSBP3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ENTREZ:5557,PRIM1,within_lineage,Lymphoid,precision_eligible,False,-0.5040968774574667,-0.6325946822370191,-0.3755990726779142,0.00024349741028423567,0.004059413135233232,0.0004374327734731569,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.41 (unadjusted contrast; not causal); copy_number: delta -0.0806 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CCND3 is associated with stronger CRISPR dependency on PRIM1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRIM1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ENTREZ:440400,RNASEK,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4617484781692947,-0.5861561851764211,-0.3373407711621683,0.00022900759254259955,0.004103290745428759,0.0004051008582123968,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.111 (unadjusted contrast; not causal); copy_number: delta 0.0149 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BLTP1 is associated with stronger CRISPR dependency on RNASEK; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RNASEK with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ENTREZ:114799,ESCO1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3168554856726369,-0.4008227843946776,-0.2328881869505962,0.00022900759254259955,0.004103290745428759,0.0004093442336740012,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.399 (unadjusted contrast; not causal); copy_number: delta 0.00291 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KIAA2026 is associated with stronger CRISPR dependency on ESCO1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ESCO1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:10186,LHFPL6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2818135194007482,-0.3565139292450921,-0.2071131095564043,0.00022900759254259955,0.004103290745428759,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.196 (unadjusted contrast; not causal); copy_number: delta -0.0358 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on LHFPL6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LHFPL6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:283748,PLA2G4D,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1880413094768296,-0.2436187762442556,-0.1324638427094036,0.00022900759254259955,0.004103290745428759,2.5311773649289936e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0376 (unadjusted contrast; not causal); copy_number: delta -0.03 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on PLA2G4D; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PLA2G4D with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:973,CD79A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0889551208394417,-0.1150532429320989,-0.0628569987467844,0.00022900759254259955,0.004103290745428759,4.502263395179459e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.155 (unadjusted contrast; not causal); copy_number: delta 0.0877 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on CD79A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CD79A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ENTREZ:7157,TP53,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.8569077390316492,-1.0602864303286224,-0.653529047734676,0.000251029093557742,0.004497865529228015,0.00046384046663702305,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.423 (unadjusted contrast; not causal); copy_number: delta 0.00229 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on TP53; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TP53 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:1871,E2F3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.5449616367402317,-0.7105320213085424,-0.3793912521719209,0.000251029093557742,0.004497865529228015,2.6913039776546925e-08,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,GSEA: RHO GTPases Activate WASPs and WAVEs (FDR=0.0317); GSEA: APC truncation mutants have impaired AXIN binding (FDR=0.0317); GSEA: APC/C-mediated degradation of cell cycle proteins (FDR=0.0317),expression: delta 0.807 (unadjusted contrast; not causal); copy_number: delta 0.506 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RB1 is associated with stronger CRISPR dependency on E2F3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb E2F3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:401089,FOXL2NB,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1374364504290243,-0.1777421748008485,-0.0971307260572001,0.000251029093557742,0.004497865529228015,1.0987765920010625e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.383 (unadjusted contrast; not causal); copy_number: delta -0.0664 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on FOXL2NB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FOXL2NB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ENTREZ:4129,MAOB,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0731544464992825,-0.0949608946439297,-0.0513479983546353,0.000251029093557742,0.004497865529228015,3.5036725300167764e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00233 (unadjusted contrast; not causal); copy_number: delta -0.0595 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PPP1R9A is associated with stronger CRISPR dependency on MAOB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAOB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7468,APC,NSD2,ENTREZ:26595,OR8B2,within_lineage,Bowel,precision_eligible,False,-0.2288547916266942,-0.2803065734046985,-0.17740300984869,0.00027104801206423353,0.004518716889711578,0.00047963876861091244,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00178 (unadjusted contrast; not causal); copy_number: delta -0.226 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in NSD2 is associated with stronger CRISPR dependency on OR8B2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR8B2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:10664,APC,CTCF,ENTREZ:644591,PPIAL4G,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2444700948887266,-0.299645959617716,-0.1892942301597373,0.0002658117314499375,0.004762736490852514,0.0005012745036982618,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0146 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in CTCF is associated with stronger CRISPR dependency on PPIAL4G; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPIAL4G with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ENTREZ:116238,TLCD1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2898273088966892,-0.3624348963725686,-0.2172197214208098,0.0002824018724592029,0.005059993762163352,0.0005334565558994634,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.226 (unadjusted contrast; not causal); copy_number: delta -0.0104 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ARID5B is associated with stronger CRISPR dependency on TLCD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TLCD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:285016,ALKAL2,within_lineage,Lung,precision_eligible,False,-0.1545576671460959,-0.1994743074386395,-0.1096410268535524,0.0003154244065560494,0.0052585281200819055,4.767316068721396e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.221 (unadjusted contrast; not causal); copy_number: delta 0.143 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on ALKAL2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ALKAL2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:440560,PRAMEF11,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2067843319398499,-0.2669482209882589,-0.146620442891441,0.0002952185163811526,0.005289638621569527,9.322218911980652e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00852 (unadjusted contrast; not causal); copy_number: delta -0.105 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on PRAMEF11; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRAMEF11 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:401494,HACD4,within_lineage,Bowel,precision_eligible,False,-0.2918379373043891,-0.3651574960540622,-0.2185183785547161,0.0003400187130530304,0.005668546652637363,0.000638525338224253,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00466 (unadjusted contrast; not causal); copy_number: delta -0.0267 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on HACD4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HACD4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:6691,SPINK2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0844584975568722,-0.1096491150569747,-0.0592678800567698,0.0003264567007612463,0.00584935522942388,4.502263395179459e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.312 (unadjusted contrast; not causal); copy_number: delta 0.0275 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on SPINK2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SPINK2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4763,TP53,NF1,ENTREZ:55009,FAM174C,within_lineage,Lung,precision_eligible,False,-0.151841360290641,-0.1962733731040447,-0.1074093474772373,0.00036580673654960574,0.006098465973715575,0.0001635001541704906,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.197 (unadjusted contrast; not causal); copy_number: delta 0.0443 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NF1 is associated with stronger CRISPR dependency on FAM174C; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FAM174C with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ENTREZ:5557,PRIM1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.5040968774574667,-0.6325946822370191,-0.3755990726779142,0.00034293628874967707,0.006144631644195273,0.0006582060541288882,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.723 (unadjusted contrast; not causal); copy_number: delta -0.0487 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CCND3 is associated with stronger CRISPR dependency on PRIM1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRIM1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ENTREZ:414062,CCL3L3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1796015702170288,-0.2213423183794773,-0.1378608220545803,0.00034293628874967707,0.006144631644195273,6.664590789067346e-11,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.066 (unadjusted contrast; not causal); copy_number: delta 0.439 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ASXL2 is associated with stronger CRISPR dependency on CCL3L3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CCL3L3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7399,TP53,USH2A,ENTREZ:79705,LRRK1,within_lineage,Lung,precision_eligible,False,-0.1522069780119981,-0.1970755148228991,-0.1073384412010972,0.00041009457863509764,0.006836800922260283,0.0007464256197534772,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: tRNA processing in the nucleus (FDR=0.0472); GSEA: snRNP Assembly (FDR=0.0472); GSEA: mRNA Splicing - Major Pathway (FDR=0.0472),expression: delta -0.0518 (unadjusted contrast; not causal); copy_number: delta 0.162 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in USH2A is associated with stronger CRISPR dependency on LRRK1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LRRK1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7468,APC,NSD2,ENTREZ:26595,OR8B2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2288547916266942,-0.2803065734046985,-0.17740300984869,0.0003881611037331123,0.006954956588992631,0.0007428162417688662,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0131 (unadjusted contrast; not causal); copy_number: delta -0.196 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in NSD2 is associated with stronger CRISPR dependency on OR8B2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR8B2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:5163,PDK1,within_lineage,Lung,precision_eligible,False,-0.0954109066810358,-0.1236382981817151,-0.0671835151803565,0.0004199101886214159,0.0070004396897620615,4.767316068721396e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.269 (unadjusted contrast; not causal); copy_number: delta -0.0597 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on PDK1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PDK1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:767,CA8,within_lineage,Lung,precision_eligible,False,-0.0797796536862612,-0.10339566804543,-0.0561636393270924,0.0004199101886214159,0.0070004396897620615,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.61 (unadjusted contrast; not causal); copy_number: delta 0.122 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on CA8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CA8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:23097,CDK19,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0833633961359934,-0.1084156088172929,-0.0583111834546938,0.0004006056795411646,0.007177934841272493,2.587704264232238e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.084 (unadjusted contrast; not causal); copy_number: delta 0.0529 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on CDK19; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CDK19 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:2923,PDIA3,within_lineage,Lung,precision_eligible,False,-0.1101891541038057,-0.1429113530355734,-0.077466955172038,0.00045080843296379353,0.007515552925638698,4.767316068721396e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.276 (unadjusted contrast; not causal); copy_number: delta -0.0337 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on PDIA3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PDIA3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:79776,TP53,ZFHX4,ENTREZ:79890,RIN3,within_lineage,Lung,precision_eligible,False,-0.124379324943504,-0.1614358546697628,-0.0873227952172452,0.0004869435875191664,0.008117972150034285,0.0009414773712833701,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.363 (unadjusted contrast; not causal); copy_number: delta 0.00134 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ZFHX4 is associated with stronger CRISPR dependency on RIN3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RIN3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:8706,B3GALNT1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1077295170110197,-0.1401177755603689,-0.0753412584616706,0.00046624661178451754,0.008354069775512124,1.0987765920010625e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.476 (unadjusted contrast; not causal); copy_number: delta -0.108 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on B3GALNT1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb B3GALNT1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:10542,LAMTOR5,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0787500030745661,-0.1025980578231377,-0.0549019483259944,0.00047749094350588514,0.008555542406958768,4.502263395179459e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0238 (unadjusted contrast; not causal); copy_number: delta -0.0652 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on LAMTOR5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LAMTOR5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:55096,EBLN2,within_lineage,Bowel,precision_eligible,False,-0.4054326261951341,-0.4393039428384678,-0.3715613095518004,0.0005682140413859904,0.009472854518385742,0.001040615355027238,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.953 (unadjusted contrast; not causal); copy_number: delta -0.0749 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on EBLN2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb EBLN2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:4850,CNOT4,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.216565427692534,-0.282326012091785,-0.1508048432932831,0.0005971917500062626,0.010700306281728517,1.0987765920010625e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.155 (unadjusted contrast; not causal); copy_number: delta -0.102 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on CNOT4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CNOT4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ENTREZ:124446,TMEM219,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1348543304511846,-0.172851047033551,-0.0968576138688182,0.0005971917500062626,0.010700306281728517,0.001230725375041839,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.176 (unadjusted contrast; not causal); copy_number: delta 0.00122 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KCNA4 is associated with stronger CRISPR dependency on TMEM219; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TMEM219 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ENTREZ:7157,TP53,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.5935115896585544,-0.768143683099566,-0.4188794962175428,0.0006371698829686882,0.011416622719899565,1.1705551323033415e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: ABC transporter disorders (FDR=0.0311); GSEA: tRNA processing in the nucleus (FDR=0.0311); GSEA: ABC-family protein mediated transport (FDR=0.0311),expression: delta -0.0785 (unadjusted contrast; not causal); copy_number: delta 0.00328 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on TP53; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TP53 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ENTREZ:64757,MTARC1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1974744369246595,-0.2498982067331207,-0.1450506671161983,0.0006884079042281977,0.012334690527669378,0.0005460658986232966,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 1.33 (unadjusted contrast; not causal); copy_number: delta -0.0747 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAP2K4 is associated with stronger CRISPR dependency on MTARC1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MTARC1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:152273,FGD5,within_lineage,Lung,precision_eligible,False,-0.2479910577134635,-0.3236007796214514,-0.1723813358054756,0.0008209698761318437,0.013686617426075213,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.245 (unadjusted contrast; not causal); copy_number: delta 0.00745 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on FGD5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FGD5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:11170,FAM107A,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1650661356552155,-0.2114290954617153,-0.1187031758487158,0.0008209698761318437,0.013686617426075213,0.0016335234270482293,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0896 (unadjusted contrast; not causal); copy_number: delta 0.0335 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on FAM107A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FAM107A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7399,TP53,USH2A,ENTREZ:9260,PDLIM7,within_lineage,Lung,precision_eligible,False,-0.1769640756238895,-0.2310163548631501,-0.1229117963846288,0.0008437655039767946,0.014066649685932365,0.0007464256197534772,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: tRNA processing in the nucleus (FDR=0.0472); GSEA: snRNP Assembly (FDR=0.0472); GSEA: mRNA Splicing - Major Pathway (FDR=0.0472),expression: delta -0.443 (unadjusted contrast; not causal); copy_number: delta -0.00204 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in USH2A is associated with stronger CRISPR dependency on PDLIM7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PDLIM7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:23219,FBXO28,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.214505765929011,-0.2803426296441706,-0.1486689022138514,0.0007994208793452833,0.014323788392779313,1.0987765920010625e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.112 (unadjusted contrast; not causal); copy_number: delta -0.12 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on FBXO28; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FBXO28 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:3845,KRAS,within_lineage,Lung,precision_eligible,False,-1.0159446991079837,-1.3269434008486185,-0.7049459973673486,0.0008846277213962009,0.014747875091711696,0.00176108825224523,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,not established,expression: delta 0.389 (unadjusted contrast; not causal); copy_number: delta 0.548 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on KRAS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KRAS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4780,TP53,NFE2L2,ENTREZ:53347,UBASH3A,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1430132715873663,-0.1833860903515602,-0.1026404528231725,0.0008865228847074211,0.014779469887032102,0.0003177466147393907,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Sema4D in semaphorin signaling (FDR=0.0395); GSEA: Signaling by VEGF (FDR=0.0395); GSEA: Phase I - Functionalization of compounds (FDR=0.0395),expression: delta -0.0227 (unadjusted contrast; not causal); copy_number: delta 0.014 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NFE2L2 is associated with stronger CRISPR dependency on UBASH3A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb UBASH3A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:23521,RPL13A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3952742324314789,-0.5074520058699298,-0.283096458993028,0.000846191927272247,0.015161818285072143,0.00034784794103089956,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.222 (unadjusted contrast; not causal); copy_number: delta -0.0394 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RHOA is associated with stronger CRISPR dependency on RPL13A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RPL13A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ENTREZ:57523,NYNRIN,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1017390271880533,-0.1327310410538883,-0.0707470133222182,0.0009291802951261467,0.016648779472744558,0.001983635476460049,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.427 (unadjusted contrast; not causal); copy_number: delta -0.000473 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KIF18A is associated with stronger CRISPR dependency on NYNRIN; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NYNRIN with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ENTREZ:64506,CPEB1,within_lineage,Bowel,precision_eligible,False,-0.2019198390993498,-0.2564584739036254,-0.1473812042950742,0.001025794295801857,0.017101302365247262,0.002137397301756624,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.123 (unadjusted contrast; not causal); copy_number: delta 0.0457 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on CPEB1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CPEB1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ENTREZ:8326,FZD9,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2010611087613321,-0.2625807572845611,-0.1395414602381031,0.0009624091356991274,0.01724416407327511,8.85093841555611e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.104 (unadjusted contrast; not causal); copy_number: delta -0.209 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in JAK2 is associated with stronger CRISPR dependency on FZD9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FZD9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ENTREZ:54785,BORCS6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1445554626407885,-0.1874920017457013,-0.1016189235358757,0.0009624091356991274,0.01724416407327511,0.0003541895182373382,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0179 (unadjusted contrast; not causal); copy_number: delta -0.075 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CDH1 is associated with stronger CRISPR dependency on BORCS6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BORCS6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ENTREZ:51704,GPRC5B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0958667672246681,-0.1252258415375474,-0.0665076929117888,0.0009800032925868305,0.01755941100604877,8.85093841555611e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.58 (unadjusted contrast; not causal); copy_number: delta 0.0553 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in JAK2 is associated with stronger CRISPR dependency on GPRC5B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GPRC5B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ENTREZ:140807,KRT72,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.122119019062041,-0.1593446354746919,-0.0848934026493901,0.0010027367707286152,0.017966742786776693,6.397730400898308e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: NoRC negatively regulates rRNA expression (FDR=0.0297); GSEA: Cellular Senescence (FDR=0.0297); GSEA: Cellular response to chemical stress (FDR=0.0297),expression: delta -0.0152 (unadjusted contrast; not causal); copy_number: delta 0.0268 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on KRT72; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KRT72 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:283092,OR4C13,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1230702768483216,-0.1609724215369872,-0.085168132159656,0.0011578373445419669,0.020745789289440705,9.322218911980652e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.000639 (unadjusted contrast; not causal); copy_number: delta -0.0336 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on OR4C13; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR4C13 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ENTREZ:401089,FOXL2NB,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1381501063083409,-0.1812482816478933,-0.0950519309687886,0.0012123339407887105,0.021722243286244475,4.502263395179459e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.17 (unadjusted contrast; not causal); copy_number: delta -0.0333 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RSPH4A is associated with stronger CRISPR dependency on FOXL2NB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FOXL2NB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:7158,TP53BP1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.267368024970112,-0.3515071410103844,-0.1832289089298395,0.0012179182096598456,0.021822300574845736,4.996071779082237e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,"ORA: p53-Dependent G1/S DNA damage checkpoint (FDR=1.92e-06); ORA: p53-Dependent G1 DNA Damage Response (FDR=1.92e-06); ORA: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (FDR=2e-06); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0413); GSEA: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (FDR=0.0413); GSEA: Vpu mediated degradation of CD4 (FDR=0.0413)",expression: delta 0.0216 (unadjusted contrast; not causal); copy_number: delta 0.00164 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on TP53BP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TP53BP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ENTREZ:4893,NRAS,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-1.43378483684841,-1.86810093000774,-0.9994687436890805,0.0012534773857014088,0.02245943944149391,0.002769700795120968,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.447 (unadjusted contrast; not causal); copy_number: delta 0.189 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in NRAS is associated with stronger CRISPR dependency on NRAS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NRAS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:23345,TP53,SYNE1,ENTREZ:5330,PLCB2,within_lineage,Bowel,precision_eligible,False,-0.2143932386248853,-0.2733681679491792,-0.1554183093005914,0.0013944135932293389,0.02324665732459092,0.002782910752464606,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.13 (unadjusted contrast; not causal); copy_number: delta -0.0337 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on PLCB2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PLCB2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ENTREZ:91612,CHURC1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.237494447867264,-0.3007834888191818,-0.1742054069153462,0.0013131700674559699,0.02352899537146925,0.0029346879448226724,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0216 (unadjusted contrast; not causal); copy_number: delta 0.144 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in CDKN2A, the presence of an annotated variant in MUC16 is associated with stronger CRISPR dependency on CHURC1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CHURC1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:10380,BPNT1,within_lineage,Bowel,precision_eligible,False,-0.4669074330805235,-0.5823142704660057,-0.3515005956950413,0.0014255816488717616,0.023766268659786805,0.0003177466147393907,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.174 (unadjusted contrast; not causal); copy_number: delta -0.0115 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on BPNT1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BPNT1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:135250,RAET1E,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1145894515087665,-0.1510985774770359,-0.0780803255404971,0.0013964207948469708,0.02502065744022866,0.00034784794103089956,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.521 (unadjusted contrast; not causal); copy_number: delta 0.0364 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RHOA is associated with stronger CRISPR dependency on RAET1E; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RAET1E with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:3346,HTN1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1259886601883399,-0.1651948000492129,-0.086782520327467,0.0014169385800206539,0.025388289085472953,9.322218911980652e-07,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00108 (unadjusted contrast; not causal); copy_number: delta 0.117 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on HTN1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HTN1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:2237,FEN1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4536906371662967,-0.585827993466725,-0.3215532808658685,0.0015787383727466587,0.028287370223935234,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.187 (unadjusted contrast; not causal); copy_number: delta -0.114 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on FEN1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FEN1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ENTREZ:29993,PACSIN1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0883223839402675,-0.1168121668253869,-0.0598326010551482,0.0015787383727466587,0.028287370223935234,8.811606588355312e-08,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.325 (unadjusted contrast; not causal); copy_number: delta 0.0107 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ATRX is associated with stronger CRISPR dependency on PACSIN1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PACSIN1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ENTREZ:55111,PLEKHJ1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0988522423899898,-0.1304272550726142,-0.0672772297073653,0.0016402942975979962,0.029390311196173163,0.0001041167154611385,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.126 (unadjusted contrast; not causal); copy_number: delta -0.0484 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNA2 is associated with stronger CRISPR dependency on PLEKHJ1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PLEKHJ1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:54545,MTMR12,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.0955127359811028,-0.1235605751364073,-0.0674648968257983,0.0018610173097186123,0.031025537820503234,2.350672500648786e-05,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.18 (unadjusted contrast; not causal); copy_number: delta -0.281 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on MTMR12; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MTMR12 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:6519,SLC3A1,within_lineage,Bowel,precision_eligible,False,-0.2113366882995231,-0.2645382327130511,-0.158135143885995,0.0018856167347267555,0.03143564168518367,0.0003177466147393907,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0711 (unadjusted contrast; not causal); copy_number: delta -0.00966 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on SLC3A1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC3A1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:389816,LRRC26,within_lineage,Lung,precision_eligible,False,-0.1077631802658565,-0.141963146165941,-0.073563214365772,0.0018856167347267555,0.03143564168518367,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.113 (unadjusted contrast; not causal); copy_number: delta -0.0628 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on LRRC26; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LRRC26 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ENTREZ:343563,OR2T29,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2318752524911528,-0.3015415163793752,-0.1622089886029303,0.0017716744320381845,0.03174434183680064,0.0023227175473404184,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00858 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TET2 is associated with stronger CRISPR dependency on OR2T29; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR2T29 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ENTREZ:64506,CPEB1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2019198390993498,-0.2564584739036254,-0.1473812042950742,0.0018104271885939227,0.03243870234061422,0.004468750801494793,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0754 (unadjusted contrast; not causal); copy_number: delta -0.0031 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on CPEB1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CPEB1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8085,TP53,KMT2D,ENTREZ:126014,OSCAR,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1554930969446876,-0.2013185777074415,-0.1096676161819337,0.0019517411992343184,0.03253802104711992,0.004149554560875475,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0954 (unadjusted contrast; not causal); copy_number: delta 0.11 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on OSCAR; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OSCAR with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:55890,GPRC5C,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0920730111939592,-0.1217962637352449,-0.0623497586526736,0.00202371041017104,0.03626024842795549,2.5311773649289936e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.755 (unadjusted contrast; not causal); copy_number: delta -0.00761 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on GPRC5C; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GPRC5C with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:944,TNFSF8,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0906311587524504,-0.1197148515439911,-0.0615474659609098,0.00202371041017104,0.03626024842795549,2.0614001215747637e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.33 (unadjusted contrast; not causal); copy_number: delta -0.0307 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on TNFSF8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TNFSF8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:10060,TP53,ABCC9,ENTREZ:65263,PYCR3,within_lineage,Lung,precision_eligible,False,-0.1190434454815337,-0.1572004587917478,-0.0808864321713197,0.0023249535955449647,0.03875994883701639,1.6138677555324986e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.475 (unadjusted contrast; not causal); copy_number: delta -0.0713 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCC9 is associated with stronger CRISPR dependency on PYCR3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PYCR3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:54629,MINDY2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2287829896913836,-0.2966493570195568,-0.1609166223632105,0.002264743034946507,0.04057900016717392,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.451 (unadjusted contrast; not causal); copy_number: delta 0.0609 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on MINDY2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MINDY2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7157,KRAS,TP53,ENTREZ:57646,USP28,within_lineage,Bowel,precision_eligible,False,-0.2891788084794125,-0.3635712790770432,-0.2147863378817818,0.0026018188531768014,0.043375646647553535,0.005309233117520593,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.121 (unadjusted contrast; not causal); copy_number: delta 0.177 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on USP28; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb USP28 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:94025,KRAS,MUC16,ENTREZ:81168,OR8J3,within_lineage,Bowel,precision_eligible,False,-0.4180329212476706,-0.5142222911657915,-0.3218435513295496,0.002625256816656143,0.043766387463647194,0.005309233117520593,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: ATF6 (ATF6-alpha) activates chaperones (FDR=0.0453); GSEA: rRNA processing in the nucleus and cytosol (FDR=0.0453); GSEA: rRNA processing (FDR=0.0453),expression: delta -0.000495 (unadjusted contrast; not causal); copy_number: delta -0.0416 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in MUC16 is associated with stronger CRISPR dependency on OR8J3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR8J3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:645745,MT1HL1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2553658145987825,-0.3310105298848044,-0.1797210993127606,0.002461950741750176,0.04411250990486612,2.6759323136671476e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0109 (unadjusted contrast; not causal); copy_number: delta -0.0154 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on MT1HL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MT1HL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ENTREZ:641455,POTEM,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2080804309506163,-0.2716521502308973,-0.1445087116703353,0.0024889115890348976,0.04459558644361336,0.0023227175473404184,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.131 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TET2 is associated with stronger CRISPR dependency on POTEM; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb POTEM with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:153579,BTNL9,within_lineage,Lung,precision_eligible,False,-0.0871310102268786,-0.1152596950584867,-0.0590023253952704,0.0027217782643680537,0.045375523397438375,2.281580096041547e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.396 (unadjusted contrast; not causal); copy_number: delta -0.274 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on BTNL9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BTNL9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:57606,SLAIN2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1082138559686604,-0.1433267675377343,-0.0731009443995864,0.0025474436756551064,0.045644347171031864,2.587704264232238e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00907 (unadjusted contrast; not causal); copy_number: delta 0.0377 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on SLAIN2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLAIN2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:10553,HTATIP2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2353982587849002,-0.3057595457096292,-0.1650369718601713,0.0025651076072300254,0.04596084430614658,3.113720411768672e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.812 (unadjusted contrast; not causal); copy_number: delta -0.0211 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on HTATIP2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HTATIP2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:79751,SLC25A22,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1808131138594747,-0.2396398419176464,-0.121986385801303,0.0027213234276943755,0.04875987347056911,4.502263395179459e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0291 (unadjusted contrast; not causal); copy_number: delta -0.0373 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on SLC25A22; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC25A22 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:1026,CDKN1A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3248516515795884,-0.4308883781076913,-0.2188149250514854,0.0027338390511839118,0.04898412473432724,4.996071779082237e-09,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,"ORA: p53-Dependent G1/S DNA damage checkpoint (FDR=1.92e-06); ORA: p53-Dependent G1 DNA Damage Response (FDR=1.92e-06); ORA: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (FDR=2e-06); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0413); GSEA: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (FDR=0.0413); GSEA: Vpu mediated degradation of CD4 (FDR=0.0413)",expression: delta -1.59 (unadjusted contrast; not causal); copy_number: delta 0.0535 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on CDKN1A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CDKN1A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:124975,GGT6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1387908150420942,-0.1839829004216421,-0.0935987296625463,0.002734590673397953,0.04899759208028155,2.0614001215747637e-06,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.352 (unadjusted contrast; not causal); copy_number: delta -0.127 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on GGT6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GGT6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ENTREZ:1843,DUSP1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1644311717459073,-0.2171387449430825,-0.1117235985487321,0.00275756311214463,0.04940920548690533,0.00027113314749751654,multiplicity_robust_computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.57 (unadjusted contrast; not causal); copy_number: delta -0.111 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRRIQ3 is associated with stronger CRISPR dependency on DUSP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DUSP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:144535,TP53,CFAP54,ENTREZ:392309,OR13J1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0990164330014781,-0.131140407650144,-0.0668924583528123,0.0028840835631701077,0.05167616174820807,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0159 (unadjusted contrast; not causal); copy_number: delta 0.0268 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CFAP54 is associated with stronger CRISPR dependency on OR13J1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR13J1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:196528,TERT,ARID2,ENTREZ:84631,SLITRK2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0875040766588685,-0.1149099056105902,-0.0600982477071467,0.002903930175882667,0.05203176752252932,0.0005548747937621566,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.372 (unadjusted contrast; not causal); copy_number: delta -0.0312 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ARID2 is associated with stronger CRISPR dependency on SLITRK2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLITRK2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:26735,OR1L3,within_lineage,Bowel,precision_eligible,False,-0.2994719288029992,-0.3695472573039344,-0.2293966003020639,0.0032973412867148937,0.054970894823943295,0.0026281298431810617,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00106 (unadjusted contrast; not causal); copy_number: delta -0.0954 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on OR1L3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR1L3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:7942,TFEB,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1073106794490978,-0.1397152748137905,-0.0749060840844052,0.0030720044746434805,0.05504327341625371,3.113720411768672e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.189 (unadjusted contrast; not causal); copy_number: delta -0.0248 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on TFEB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TFEB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7157,APC,TP53,ENTREZ:1175,AP2S1,within_lineage,Bowel,precision_eligible,False,-0.7165313576227158,-0.9243723085727455,-0.5086904066726861,0.0033623111005217816,0.05605402468250514,0.0069196764854982966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0472 (unadjusted contrast; not causal); copy_number: delta 0.0668 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on AP2S1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AP2S1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1029,TP53,CDKN2A,ENTREZ:6229,RPS24,within_lineage,Lymphoid,precision_eligible,False,-0.5284498356662476,-0.6857558157360488,-0.3711438555964463,0.0033623111005217816,0.05605402468250514,0.0069196764854982966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.387 (unadjusted contrast; not causal); copy_number: delta 0.0593 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CDKN2A is associated with stronger CRISPR dependency on RPS24; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RPS24 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:154664,TP53,ABCA13,ENTREZ:9465,AKAP7,within_lineage,Lung,precision_eligible,False,-0.0975334508640267,-0.1294754215430743,-0.0655914801849791,0.0035396509593826394,0.05901050685461463,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.325 (unadjusted contrast; not causal); copy_number: delta -0.0366 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCA13 is associated with stronger CRISPR dependency on AKAP7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AKAP7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:32,TTN,ACACB,ENTREZ:9378,NRXN1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1506769001883211,-0.1929209509564317,-0.1084328494202106,0.0033413816079063316,0.059869893729036464,0.00901739096191111,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.367 (unadjusted contrast; not causal); copy_number: delta -0.045 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in ACACB is associated with stronger CRISPR dependency on NRXN1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NRXN1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ENTREZ:79228,THOC6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3976605311110858,-0.518244032347418,-0.2770770298747536,0.0033472940496652574,0.059975831123002005,0.0005460658986232966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.122 (unadjusted contrast; not causal); copy_number: delta 0.0085 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAP2K4 is associated with stronger CRISPR dependency on THOC6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb THOC6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:55284,UBE2W,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2343127242972894,-0.3060894117214352,-0.1625360368731436,0.003653943752280805,0.06547029038027224,0.00034784794103089956,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.271 (unadjusted contrast; not causal); copy_number: delta -0.0546 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RHOA is associated with stronger CRISPR dependency on UBE2W; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb UBE2W with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:55294,ENTREZ:8085,FBXW7,KMT2D,ENTREZ:9575,CLOCK,within_lineage,Bowel,precision_eligible,False,-0.3562188237254975,-0.4201434247728417,-0.2922942226781534,0.003983602246343726,0.06641174238968597,0.004913700751351219,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.123 (unadjusted contrast; not causal); copy_number: delta 0.0438 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in FBXW7, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on CLOCK; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CLOCK with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:23345,KRAS,SYNE1,ENTREZ:10845,CLPX,within_lineage,Bowel,precision_eligible,False,-0.2820737647830141,-0.3570565879499933,-0.2070909416160349,0.003983602246343726,0.06641174238968597,0.0003772536524379831,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.446 (unadjusted contrast; not causal); copy_number: delta -0.0828 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on CLPX; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CLPX with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7179,TP53,TPTE,ENTREZ:26191,PTPN22,within_lineage,Lung,precision_eligible,False,-0.0724935254741172,-0.0963698288562775,-0.048617222091957,0.003983602246343726,0.06641174238968597,0.00445850481036875,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.259 (unadjusted contrast; not causal); copy_number: delta -0.0621 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on PTPN22; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PTPN22 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:8289,ENTREZ:10973,ARID1A,ASCC3,ENTREZ:10658,CELF1,within_lineage,Bowel,precision_eligible,False,-0.2289225971744218,-0.2555039260002002,-0.2023412683486434,0.0040032648159738626,0.06673954256355986,0.008003446939450268,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.131 (unadjusted contrast; not causal); copy_number: delta -0.0772 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in ARID1A, the presence of an annotated variant in ASCC3 is associated with stronger CRISPR dependency on CELF1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CELF1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ENTREZ:5604,MAP2K1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4194115920074878,-0.5535817966377565,-0.285241387377219,0.0037685574123857753,0.06752390426087299,4.725210079663258e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: rRNA processing in the nucleus and cytosol (FDR=0.0311); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0311); GSEA: p75NTR recruits signalling complexes (FDR=0.0311),expression: delta -0.168 (unadjusted contrast; not causal); copy_number: delta 0.04 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in BRAF is associated with stronger CRISPR dependency on MAP2K1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAP2K1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:8289,BRAF,ARID1A,ENTREZ:476,ATP1A1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.9575267196900482,-1.24307846357604,-0.6719749758040563,0.0038325210786035154,0.06866998643535865,0.010437788189546934,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.672 (unadjusted contrast; not causal); copy_number: delta 0.0607 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in ARID1A is associated with stronger CRISPR dependency on ATP1A1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ATP1A1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:57646,USP28,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2587779406145277,-0.3446715571725727,-0.1728843240564827,0.0038857773460366694,0.0696242165849721,4.996071779082237e-09,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,"ORA: p53-Dependent G1/S DNA damage checkpoint (FDR=1.92e-06); ORA: p53-Dependent G1 DNA Damage Response (FDR=1.92e-06); ORA: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (FDR=2e-06); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0413); GSEA: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (FDR=0.0413); GSEA: Vpu mediated degradation of CD4 (FDR=0.0413)",expression: delta 0.123 (unadjusted contrast; not causal); copy_number: delta 0.0235 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on USP28; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb USP28 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5728,ENTREZ:22986,PTEN,SORCS3,ENTREZ:84765,ZNF577,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.259393710674108,-0.317074084669507,-0.2017133366787089,0.003984735937237002,0.07139732754144598,0.01082749358525764,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.384 (unadjusted contrast; not causal); copy_number: delta -0.0424 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PTEN, the presence of an annotated variant in SORCS3 is associated with stronger CRISPR dependency on ZNF577; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF577 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ENTREZ:51134,CEP83,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.124475552334508,-0.1655490697681812,-0.0834020349008349,0.003984735937237002,0.07139732754144598,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.726 (unadjusted contrast; not causal); copy_number: delta 0.0193 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RSPH4A is associated with stronger CRISPR dependency on CEP83; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CEP83 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:29072,TP53,SETD2,ENTREZ:833,CARS1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.263373431137873,-0.3495741959547086,-0.1771726663210374,0.003988472937188771,0.07146428600840121,0.0001948870953143044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.171 (unadjusted contrast; not causal); copy_number: delta 0.0829 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SETD2 is associated with stronger CRISPR dependency on CARS1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CARS1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:1029,ENTREZ:7179,CDKN2A,TPTE,ENTREZ:6665,SOX15,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2380742575909102,-0.3021354551822908,-0.1740130599995297,0.004123098026325671,0.07387645879369964,0.010998925883641243,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.189 (unadjusted contrast; not causal); copy_number: delta -0.0716 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in CDKN2A, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on SOX15; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SOX15 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:1029,ENTREZ:2195,CDKN2A,FAT1,ENTREZ:91754,NEK9,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1984858788636209,-0.2563916864072514,-0.1405800713199903,0.004303816355276022,0.07711451670469832,0.011298188586168408,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0957 (unadjusted contrast; not causal); copy_number: delta 0.141 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in CDKN2A, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on NEK9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NEK9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:602,BCL3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1429449824091862,-0.1882533370974259,-0.0976366277209466,0.004303816355276022,0.07711451670469832,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0689 (unadjusted contrast; not causal); copy_number: delta 0.00704 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on BCL3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BCL3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:2108,ETFA,within_lineage,Lung,precision_eligible,False,-0.0924730577344994,-0.1231829592973903,-0.0617631561716086,0.004662196558080519,0.07772477713343674,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.16 (unadjusted contrast; not causal); copy_number: delta -0.137 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on ETFA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ETFA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:7416,VDAC1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3131620902481931,-0.4096112559895326,-0.2167129245068536,0.00436281300817872,0.0781716013942458,3.113720411768672e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.291 (unadjusted contrast; not causal); copy_number: delta 0.168 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on VDAC1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb VDAC1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5395,TP53,PMS2,ENTREZ:57224,NHSL1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1777671949003817,-0.233244464017383,-0.1222899257833804,0.004503816393648966,0.08069805861887497,0.01177957139473931,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0399 (unadjusted contrast; not causal); copy_number: delta -0.099 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PMS2 is associated with stronger CRISPR dependency on NHSL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NHSL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9863,TP53,MAGI2,ENTREZ:5325,PLAGL1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1382951871501907,-0.1847534007981637,-0.0918369735022176,0.004503816393648966,0.08069805861887497,0.01098138622656085,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.734 (unadjusted contrast; not causal); copy_number: delta 0.0988 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAGI2 is associated with stronger CRISPR dependency on PLAGL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PLAGL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ENTREZ:732,C8B,within_lineage,Head and Neck,precision_eligible,False,-0.1194990991064745,-0.1572278020780054,-0.0817703961349436,0.00488315719449601,0.081408473435535,0.006938299567639482,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00888 (unadjusted contrast; not causal); copy_number: delta -0.0587 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PIK3CA is associated with stronger CRISPR dependency on C8B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C8B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:1788,TTN,DNMT3A,ENTREZ:726,CAPN5,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1812039170179898,-0.2343498611348994,-0.1280579729010803,0.004683669912045113,0.0839206211085026,4.6964441538316514e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.529 (unadjusted contrast; not causal); copy_number: delta 0.00218 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in DNMT3A is associated with stronger CRISPR dependency on CAPN5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CAPN5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:10051,TP53,SMC4,ENTREZ:55847,CISD1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1800235429049502,-0.2372537796471876,-0.1227933061627128,0.004683669912045113,0.0839206211085026,0.012375844226358942,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.205 (unadjusted contrast; not causal); copy_number: delta 0.0348 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SMC4 is associated with stronger CRISPR dependency on CISD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CISD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:10060,TP53,ABCC9,ENTREZ:6822,SULT2A1,within_lineage,Lung,precision_eligible,False,-0.0768562080518012,-0.1025373743145856,-0.0511750417890168,0.005172594379414986,0.08623376134686639,1.6138677555324986e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0192 (unadjusted contrast; not causal); copy_number: delta -0.0958 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCC9 is associated with stronger CRISPR dependency on SULT2A1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SULT2A1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7179,TP53,TPTE,ENTREZ:133396,IL31RA,within_lineage,Lung,precision_eligible,False,-0.1033703789219685,-0.1379537070274535,-0.0687870508164835,0.005246136089786396,0.08745979568012989,0.00445850481036875,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.134 (unadjusted contrast; not causal); copy_number: delta 0.176 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on IL31RA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb IL31RA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:79629,OCEL1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0897548539669335,-0.1200649560167391,-0.059444751917128,0.004929200049711914,0.08831995796203782,0.00034784794103089956,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0547 (unadjusted contrast; not causal); copy_number: delta 9.51e-05 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RHOA is associated with stronger CRISPR dependency on OCEL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OCEL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5728,TP53,PTEN,ENTREZ:5728,PTEN,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1957797435256468,-0.2637439296968085,-0.127815557354485,0.004932859289772991,0.08838552315012269,0.012795752250704768,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,not established,expression: delta -0.272 (unadjusted contrast; not causal); copy_number: delta -0.0381 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PTEN is associated with stronger CRISPR dependency on PTEN; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PTEN with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:2306,FOXD2,within_lineage,Bowel,precision_eligible,False,-0.2470311865543689,-0.3212027561856869,-0.1728596169230508,0.005558829230525286,0.09267279010717967,0.000638525338224253,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0495 (unadjusted contrast; not causal); copy_number: delta 0.0441 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on FOXD2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FOXD2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:3060,HCRT,within_lineage,Lung,precision_eligible,False,-0.0999362463940641,-0.1335132981024317,-0.0663591946856964,0.005559305814648213,0.09268073537381062,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0179 (unadjusted contrast; not causal); copy_number: delta 0.278 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on HCRT; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HCRT with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:6672,SP100,within_lineage,Lung,precision_eligible,False,-0.1182525558835403,-0.1580366687289942,-0.0784684430380864,0.005703633295392852,0.09508685899716253,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.768 (unadjusted contrast; not causal); copy_number: delta 0.232 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on SP100; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SP100 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:1788,TTN,DNMT3A,ENTREZ:163081,ZNF567,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1600283201215986,-0.2073235984556355,-0.1127330417875616,0.00534589036124507,0.095786092512602,4.6964441538316514e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.191 (unadjusted contrast; not causal); copy_number: delta -0.0897 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in DNMT3A is associated with stronger CRISPR dependency on ZNF567; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF567 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:10664,ENTREZ:27445,CTCF,PCLO,ENTREZ:7737,RNF113A,within_lineage,Uterus,precision_eligible,False,-0.354473847390895,-0.4056734537171304,-0.3032742410646596,0.005832974354036187,0.09724313980429242,0.013562427596677931,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.334 (unadjusted contrast; not causal); copy_number: delta 0.0336 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in CTCF, the presence of an annotated variant in PCLO is associated with stronger CRISPR dependency on RNF113A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RNF113A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:84619,ZGPAT,within_lineage,Lung,precision_eligible,False,-0.1336724606307798,-0.1787906495719174,-0.0885542716896422,0.005832974354036187,0.09724313980429242,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.019 (unadjusted contrast; not causal); copy_number: delta -0.127 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on ZGPAT; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZGPAT with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7157,APC,TP53,ENTREZ:1175,AP2S1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.7165313576227158,-0.9243723085727455,-0.5086904066726861,0.0056553869216895815,0.10133156093185436,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.206 (unadjusted contrast; not causal); copy_number: delta 0.0202 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on AP2S1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AP2S1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ENTREZ:27319,BHLHE22,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1711211598574592,-0.2279380343399347,-0.1143042853749838,0.005713842771752029,0.10237895567503429,1.2538043515616061e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.747 (unadjusted contrast; not causal); copy_number: delta -0.0653 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CNTNAP2 is associated with stronger CRISPR dependency on BHLHE22; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BHLHE22 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1009,TP53,CDH11,ENTREZ:440023,KRTAP5-6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1369236468589141,-0.1823974901647838,-0.0914498035530444,0.0057202322570301225,0.10249344059458898,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0113 (unadjusted contrast; not causal); copy_number: delta 0.132 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CDH11 is associated with stronger CRISPR dependency on KRTAP5-6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KRTAP5-6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:23345,TP53,SYNE1,ENTREZ:220064,LTO1,within_lineage,Lung,precision_eligible,False,-0.384138370666213,-0.5143924938885018,-0.2538842474439241,0.006199182348877982,0.10334829526673821,0.0022582247839471313,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (FDR=0.0496); GSEA: mRNA Splicing - Minor Pathway (FDR=0.0496); GSEA: Transport of the SLBP Dependant Mature mRNA (FDR=0.0496),expression: delta -0.239 (unadjusted contrast; not causal); copy_number: delta -0.192 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on LTO1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LTO1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:4191,MDH2,within_lineage,Bowel,precision_eligible,False,-0.3655171080703433,-0.4765220105851585,-0.2545122055555281,0.006199182348877982,0.10334829526673821,0.000638525338224253,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.162 (unadjusted contrast; not causal); copy_number: delta -0.138 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on MDH2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MDH2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:81875,ISG20L2,within_lineage,Lung,precision_eligible,False,-0.2627269285591735,-0.3517907341953276,-0.1736631229230195,0.006199182348877982,0.10334829526673821,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.137 (unadjusted contrast; not causal); copy_number: delta -0.087 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on ISG20L2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ISG20L2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7157,APC,TP53,ENTREZ:81832,NETO1,within_lineage,Bowel,precision_eligible,False,-0.1829894838298278,-0.2386424293697036,-0.127336538289952,0.006228558171021293,0.10383802777817491,0.0069196764854982966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.866 (unadjusted contrast; not causal); copy_number: delta -0.143 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on NETO1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NETO1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:8085,ENTREZ:84159,KMT2D,ARID5B,ENTREZ:4502,MT2A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.6793777172299682,-0.8144111502924366,-0.5443442841674998,0.00583080896002778,0.10447472146406894,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.613 (unadjusted contrast; not causal); copy_number: delta -0.00223 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KMT2D, the presence of an annotated variant in ARID5B is associated with stronger CRISPR dependency on MT2A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MT2A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:5549,PRELP,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1282708923710413,-0.1716068010601702,-0.0849349836819124,0.00583080896002778,0.10447472146406894,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.139 (unadjusted contrast; not causal); copy_number: delta 0.0146 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on PRELP; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRELP with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:23196,FAM120A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1569482013636321,-0.2099990396849371,-0.103897363042327,0.005884454124631876,0.10543591975890733,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0914 (unadjusted contrast; not causal); copy_number: delta -0.00202 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on FAM120A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FAM120A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:80816,APC,ASXL3,ENTREZ:284119,CAVIN1,within_lineage,Bowel,precision_eligible,False,-0.1449790746303651,-0.1892860705851323,-0.1006720786755979,0.006710621575404553,0.11187464103613262,0.017142745966188252,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.1 (unadjusted contrast; not causal); copy_number: delta -0.0406 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ASXL3 is associated with stronger CRISPR dependency on CAVIN1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CAVIN1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:11231,SEC63,within_lineage,Lung,precision_eligible,False,-0.2299064674556811,-0.3084367877909376,-0.1513761471204247,0.006937989241701093,0.11566515071758714,7.372053965892916e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.288 (unadjusted contrast; not causal); copy_number: delta -0.0789 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on SEC63; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SEC63 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:80003,PCNX2,within_lineage,Lymphoid,precision_eligible,False,-0.199257659342317,-0.2618431155516785,-0.1366722031329555,0.006937989241701093,0.11566515071758714,0.0007464256197534772,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.163 (unadjusted contrast; not causal); copy_number: delta 0.0304 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on PCNX2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PCNX2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:472,APC,ATM,ENTREZ:4144,MAT2A,within_lineage,Bowel,precision_eligible,False,-0.6091601027295916,-0.7962205306807777,-0.4220996747784056,0.007003576456170684,0.11675857343452867,0.0006893549193769735,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.129 (unadjusted contrast; not causal); copy_number: delta 0.0216 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on MAT2A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAT2A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5290,ENTREZ:2956,PIK3CA,MSH6,ENTREZ:8605,PLA2G4C,within_lineage,Bowel,precision_eligible,False,-0.4319875109059512,-0.5106939342315813,-0.3532810875803212,0.007003576456170684,0.11675857343452867,0.0045700336522369765,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.834 (unadjusted contrast; not causal); copy_number: delta 0.0297 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PIK3CA, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on PLA2G4C; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PLA2G4C with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5290,ENTREZ:2956,PIK3CA,MSH6,ENTREZ:64922,LRRC19,within_lineage,Bowel,precision_eligible,False,-0.2683822956107458,-0.3172406689704936,-0.219523922250998,0.007003576456170684,0.11675857343452867,0.0045700336522369765,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.32 (unadjusted contrast; not causal); copy_number: delta 0.0328 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PIK3CA, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on LRRC19; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LRRC19 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:80731,TERT,THSD7B,ENTREZ:10494,STK25,within_lineage,Skin,precision_eligible,False,-0.1770529453530737,-0.2311423299879351,-0.1229635607182122,0.007030146969796672,0.11720153786645969,0.018301870541450854,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.307 (unadjusted contrast; not causal); copy_number: delta 0.0251 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in THSD7B is associated with stronger CRISPR dependency on STK25; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb STK25 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9863,TP53,MAGI2,ENTREZ:200316,APOBEC3F,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2789494183808538,-0.3669749519289146,-0.1909238848327929,0.0067931839662511515,0.12171827401542697,0.01098138622656085,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.258 (unadjusted contrast; not causal); copy_number: delta 0.0221 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAGI2 is associated with stronger CRISPR dependency on APOBEC3F; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb APOBEC3F with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ENTREZ:79767,ELMO3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2310374498282762,-0.3085781026026104,-0.1534967970539419,0.0067931839662511515,0.12171827401542697,8.85093841555611e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.134 (unadjusted contrast; not causal); copy_number: delta 0.0105 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in JAK2 is associated with stronger CRISPR dependency on ELMO3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ELMO3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:4528,MTIF2,within_lineage,Lung,precision_eligible,False,-0.0971366426324252,-0.1304653782909527,-0.0638079069738977,0.007398145723085474,0.12333654756166026,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.235 (unadjusted contrast; not causal); copy_number: delta -0.0688 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on MTIF2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MTIF2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:3298,HSF2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2293891271701944,-0.304057343071662,-0.1547209112687268,0.00723470099557173,0.1296292463995558,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0855 (unadjusted contrast; not causal); copy_number: delta 0.00175 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on HSF2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HSF2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:203111,ERICH5,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1749047090504593,-0.2343076882015265,-0.1155017298993921,0.007291617460622832,0.13064905889447673,9.322218911980652e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.367 (unadjusted contrast; not causal); copy_number: delta -0.0256 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on ERICH5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ERICH5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:130813,C2orf50,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2440715626141606,-0.3278265211503952,-0.160316604077926,0.007464877677913867,0.13375348455245586,2.5311773649289936e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.23 (unadjusted contrast; not causal); copy_number: delta 0.0217 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on C2orf50; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C2orf50 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:8233,ZRSR2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4729718306066564,-0.6345452796261304,-0.3113983815871823,0.007490848096745756,0.1342188148852394,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.164 (unadjusted contrast; not causal); copy_number: delta 0.107 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on ZRSR2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZRSR2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:1876,E2F6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.902017972405021,-1.1764482046972786,-0.6275877401127634,0.007912916869474167,0.1417813191229485,9.322218911980652e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.259 (unadjusted contrast; not causal); copy_number: delta 0.0261 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on E2F6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb E2F6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:952,CD38,within_lineage,Lung,precision_eligible,False,-0.0651401087309439,-0.0876559970652377,-0.0426242203966501,0.008586149276116695,0.14314208562569655,7.372053965892916e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.875 (unadjusted contrast; not causal); copy_number: delta -0.0601 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on CD38; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CD38 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:6375,XCL1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2650083277942965,-0.3470572021104088,-0.1829594534781841,0.00803230478152065,0.14392047664684268,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00716 (unadjusted contrast; not causal); copy_number: delta -0.0547 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on XCL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb XCL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:8284,KDM5D,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.079365150190891,-0.1034537730519674,-0.0552765273298145,0.008110523822180386,0.1453219824313974,5.265940490010591e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0675 (unadjusted contrast; not causal); copy_number: delta -0.136 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on KDM5D; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KDM5D with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:7988,ZNF212,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1033082674307014,-0.1387928589145055,-0.0678236759468973,0.008156021974006583,0.14613720494541874,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.183 (unadjusted contrast; not causal); copy_number: delta -0.129 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on ZNF212; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF212 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:2956,APC,MSH6,ENTREZ:80167,ABHD18,within_lineage,Bowel,precision_eligible,False,-0.3557221388007519,-0.4666766960833077,-0.244767581518196,0.008871315896152752,0.14789617776061145,0.023576165448393346,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.603 (unadjusted contrast; not causal); copy_number: delta 0.104 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on ABHD18; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ABHD18 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:64902,AGXT2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1598961411797771,-0.2151448940808343,-0.10464738827872,0.008348294656754242,0.1495822903723155,2.5311773649289936e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0248 (unadjusted contrast; not causal); copy_number: delta -0.0822 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on AGXT2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AGXT2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:341640,TP53,FREM2,ENTREZ:23435,TARDBP,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3728641686900101,-0.5005441210793861,-0.2451842163006342,0.008348761256532907,0.1495906507700314,0.008119808572620044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.171 (unadjusted contrast; not causal); copy_number: delta 0.000785 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FREM2 is associated with stronger CRISPR dependency on TARDBP; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TARDBP with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ENTREZ:6434,TRA2B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2956183790056134,-0.3976354999582602,-0.1936012580529666,0.008368892665201378,0.14995135943459859,0.0001041167154611385,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0622 (unadjusted contrast; not causal); copy_number: delta 0.0198 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNA2 is associated with stronger CRISPR dependency on TRA2B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TRA2B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:197259,MLKL,within_lineage,Lymphoid,precision_eligible,False,-0.1296567229344545,-0.1711309141986343,-0.0881825316702747,0.009057181932214156,0.15099480220717396,0.0007464256197534772,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.674 (unadjusted contrast; not causal); copy_number: delta 0.173 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on MLKL; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MLKL with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:442444,FAM47C,within_lineage,Lung,precision_eligible,False,-0.1085217566540291,-0.1462225302635331,-0.0708209830445251,0.009190636193823879,0.1532196553663882,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00789 (unadjusted contrast; not causal); copy_number: delta 0.119 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on FAM47C; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FAM47C with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8085,TP53,KMT2D,ENTREZ:64981,MRPL34,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.3386706402774299,-0.4492914717105924,-0.2280498088442672,0.009319235031982946,0.15536356240913363,0.004149554560875475,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0563 (unadjusted contrast; not causal); copy_number: delta -0.141 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on MRPL34; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MRPL34 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:55294,ENTREZ:1387,FBXW7,CREBBP,ENTREZ:140688,NOL4L,within_lineage,Bowel,precision_eligible,False,-0.2121290952921373,-0.2551334564202824,-0.1691247341639922,0.009319235031982946,0.15536356240913363,0.023841817447146505,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.801 (unadjusted contrast; not causal); copy_number: delta -0.31 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in FBXW7, the presence of an annotated variant in CREBBP is associated with stronger CRISPR dependency on NOL4L; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NOL4L with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:4089,TERT,SMAD4,ENTREZ:79005,SCNM1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1587991993833861,-0.2099572700563992,-0.1076411287103732,0.008774749603747715,0.1572233847915546,0.022292376166384142,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: ABC transporter disorders (FDR=0.0425); GSEA: p53-Independent G1/S DNA Damage Checkpoint (FDR=0.0425); GSEA: Mitochondrial ribosome-associated quality control (FDR=0.0425),expression: delta -0.35 (unadjusted contrast; not causal); copy_number: delta -0.0819 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in SMAD4 is associated with stronger CRISPR dependency on SCNM1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SCNM1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:54414,SIAE,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1007667827585604,-0.1337246109235669,-0.0678089545935538,0.009533760878003212,0.1589399825286131,2.350672500648786e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.491 (unadjusted contrast; not causal); copy_number: delta -0.0107 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on SIAE; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SIAE with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ENTREZ:10908,PNPLA6,within_lineage,Bladder/Urinary Tract,precision_eligible,False,-0.2009348451844474,-0.2556491831580785,-0.1462205072108163,0.009533805500976981,0.15894072645063528,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.467 (unadjusted contrast; not causal); copy_number: delta -0.0928 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PIK3CA is associated with stronger CRISPR dependency on PNPLA6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PNPLA6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5728,ENTREZ:19,PTEN,ABCA1,ENTREZ:5592,PRKG1,within_lineage,Uterus,precision_eligible,False,-0.2032345757364915,-0.24475353137138,-0.1617156201016031,0.009752169989927855,0.16258114165538398,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.177 (unadjusted contrast; not causal); copy_number: delta 0.0207 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PTEN, the presence of an annotated variant in ABCA1 is associated with stronger CRISPR dependency on PRKG1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRKG1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:6484,ST3GAL4,within_lineage,Ovary/Fallopian Tube,precision_eligible,False,-0.1600600794668911,-0.2077448426588251,-0.1123753162749571,0.009795411139251527,0.16330202689741674,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.752 (unadjusted contrast; not causal); copy_number: delta 0.0407 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on ST3GAL4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ST3GAL4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:54964,C1orf56,within_lineage,Bowel,precision_eligible,False,-0.2335157475156759,-0.307110031501706,-0.1599214635296457,0.009862871369967371,0.1644266751897912,0.000638525338224253,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.017 (unadjusted contrast; not causal); copy_number: delta -0.125 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on C1orf56; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C1orf56 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8289,TP53,ARID1A,ENTREZ:939,CD27,within_lineage,Uterus,precision_eligible,False,-0.2951127036597989,-0.3691660484451664,-0.2210593588744314,0.00988300089028143,0.16476226002855165,0.02543276212525102,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0149 (unadjusted contrast; not causal); copy_number: delta 0.00844 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ARID1A is associated with stronger CRISPR dependency on CD27; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CD27 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:5173,PDYN,within_lineage,Bowel,precision_eligible,False,-0.1975055113013812,-0.2548348946416095,-0.140176127961153,0.010337716145959257,0.1723429446836156,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0 (unadjusted contrast; not causal); copy_number: delta -0.104 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on PDYN; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PDYN with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:171017,ZNF384,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1327184833915675,-0.1785399958555326,-0.0868969709276024,0.009826717246715855,0.17607223187979562,1.0987765920010625e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.62 (unadjusted contrast; not causal); copy_number: delta -0.0262 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on ZNF384; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF384 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:3667,IRS1,within_lineage,Lung,precision_eligible,False,-0.1348245352327743,-0.1821740859055165,-0.087474984560032,0.010897362461550732,0.1816729642593679,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.4 (unadjusted contrast; not causal); copy_number: delta 0.0145 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on IRS1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb IRS1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:10664,ENTREZ:27445,CTCF,PCLO,ENTREZ:7737,RNF113A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.354473847390895,-0.4056734537171304,-0.3032742410646596,0.010198370070971238,0.1827313979683431,0.027567910904318118,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0473 (unadjusted contrast; not causal); copy_number: delta -0.0832 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in CTCF, the presence of an annotated variant in PCLO is associated with stronger CRISPR dependency on RNF113A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RNF113A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7179,TP53,TPTE,ENTREZ:53822,FXYD7,within_lineage,Lung,precision_eligible,False,-0.1261273175255752,-0.1704747718638014,-0.081779863187349,0.010971648908774766,0.18291141430809343,0.00445850481036875,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.548 (unadjusted contrast; not causal); copy_number: delta -0.0129 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on FXYD7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FXYD7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8289,TP53,ARID1A,ENTREZ:140462,ASB9,within_lineage,Lung,precision_eligible,False,-0.0815062703966449,-0.1101597546143462,-0.0528527861789437,0.010971648908774766,0.18291141430809343,0.01796889823527527,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.345 (unadjusted contrast; not causal); copy_number: delta 0.00406 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ARID1A is associated with stronger CRISPR dependency on ASB9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ASB9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:8289,ENTREZ:23039,ARID1A,XPO7,ENTREZ:402381,SOHLH1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2693597833961577,-0.3435167472349635,-0.1952028195573519,0.01023607931633742,0.18340706114531563,0.027690107213473245,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0826 (unadjusted contrast; not causal); copy_number: delta -0.0512 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in ARID1A, the presence of an annotated variant in XPO7 is associated with stronger CRISPR dependency on SOHLH1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SOHLH1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:567,B2M,within_lineage,Bowel,precision_eligible,False,-0.3048955833662344,-0.3484117198943587,-0.2613794468381101,0.011057441077639112,0.18434167944636143,0.001040615355027238,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.566 (unadjusted contrast; not causal); copy_number: delta -0.0244 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on B2M; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb B2M with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:5868,RAB5A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1416745981056749,-0.1909389171375571,-0.0924102790737927,0.010341325647031259,0.18529283397027568,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.251 (unadjusted contrast; not causal); copy_number: delta 0.0111 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on RAB5A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RAB5A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:6597,TTN,SMARCA4,ENTREZ:6532,SLC6A4,within_lineage,Lung,precision_eligible,False,-0.1665204340971208,-0.2139838936071419,-0.1190569745870997,0.011117209254080107,0.185338091359861,0.02895722527541212,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0803 (unadjusted contrast; not causal); copy_number: delta -0.0045 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in SMARCA4 is associated with stronger CRISPR dependency on SLC6A4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC6A4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:10664,APC,CTCF,ENTREZ:162333,MARCHF10,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2907510525384339,-0.3751469215884142,-0.2063551834884536,0.01035443485426499,0.1855277208931277,0.0005012745036982618,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0274 (unadjusted contrast; not causal); copy_number: delta -0.0831 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in CTCF is associated with stronger CRISPR dependency on MARCHF10; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MARCHF10 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:85395,SLX9,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.2220026580480833,-0.2955289909801685,-0.148476325115998,0.011144530942720212,0.18579357883963724,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.194 (unadjusted contrast; not causal); copy_number: delta 0.311 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on SLX9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLX9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ENTREZ:81472,OR2C3,within_lineage,Bowel,precision_eligible,False,-0.3058711213509473,-0.3972881163296004,-0.2144541263722942,0.011228266564971437,0.18718955871661727,0.002137397301756624,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00485 (unadjusted contrast; not causal); copy_number: delta 0.0122 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on OR2C3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR2C3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:26046,TP53,LTN1,ENTREZ:81027,TUBB1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1100198669193094,-0.1489221830029065,-0.0711175508357123,0.010478265623871417,0.1877464842331722,0.02841600679718784,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.279 (unadjusted contrast; not causal); copy_number: delta -0.264 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LTN1 is associated with stronger CRISPR dependency on TUBB1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TUBB1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ENTREZ:6197,RPS6KA3,within_lineage,Skin,precision_eligible,False,-0.3803516974236285,-0.4796768524793259,-0.2810265423679312,0.011264806604962645,0.18779872789886487,0.029553587251572734,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.968 (unadjusted contrast; not causal); copy_number: delta -0.0538 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NRAS is associated with stronger CRISPR dependency on RPS6KA3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RPS6KA3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:26269,FBXO8,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.0978721360916509,-0.1303399616226667,-0.0654043105606352,0.01133427586012871,0.1889568691973157,2.350672500648786e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.245 (unadjusted contrast; not causal); copy_number: delta -0.0957 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on FBXO8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FBXO8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:1788,TTN,DNMT3A,ENTREZ:5553,PRG2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2726966798403681,-0.3569936281725235,-0.1883997315082127,0.010583016275787656,0.18962337563145884,4.6964441538316514e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0371 (unadjusted contrast; not causal); copy_number: delta -0.0815 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in DNMT3A is associated with stronger CRISPR dependency on PRG2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRG2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:54662,TBC1D13,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0946942020302668,-0.127678794589325,-0.0617096094712086,0.010600029742601397,0.18992821793013284,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0409 (unadjusted contrast; not causal); copy_number: delta 0.0185 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on TBC1D13; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TBC1D13 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ENTREZ:8036,SHOC2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.8053495850970134,-1.078103466546513,-0.5325957036475137,0.010767100102458974,0.19292173554161343,0.002769700795120968,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0333 (unadjusted contrast; not causal); copy_number: delta 0.0656 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in NRAS is associated with stronger CRISPR dependency on SHOC2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SHOC2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5290,ENTREZ:7273,PIK3CA,TTN,ENTREZ:5338,PLD2,within_lineage,Uterus,precision_eligible,False,-0.1159039953545958,-0.1402568892383354,-0.0915511014708562,0.011618269600969811,0.19369140793655182,0.029971056485900996,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (FDR=0.0243); GSEA: Phosphorylation of the APC/C (FDR=0.0243); GSEA: KEAP1-NFE2L2 pathway (FDR=0.0243),expression: delta 0.607 (unadjusted contrast; not causal); copy_number: delta 0.00192 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PIK3CA, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on PLD2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PLD2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ENTREZ:114836,SLAMF6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2089883369882346,-0.2769104635685215,-0.1410662104079477,0.010843623507923459,0.1942928594330307,0.0004093442336740012,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.481 (unadjusted contrast; not causal); copy_number: delta -0.108 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KIAA2026 is associated with stronger CRISPR dependency on SLAMF6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLAMF6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:84871,AGBL4,within_lineage,Bowel,precision_eligible,False,-0.1921258748693169,-0.248644221443542,-0.1356075282950919,0.011692413128691657,0.1949274753344566,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00833 (unadjusted contrast; not causal); copy_number: delta 0.0528 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on AGBL4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AGBL4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:23480,SEC61G,within_lineage,Lung,precision_eligible,False,-0.2730242915316927,-0.3696960650867803,-0.1763525179766051,0.011792786995566507,0.19660083602092263,7.372053965892916e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.207 (unadjusted contrast; not causal); copy_number: delta -0.111 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on SEC61G; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SEC61G with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:861,RUNX1,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.261689626053447,-0.3489024413432647,-0.1744768107636292,0.011792786995566507,0.19660083602092263,0.03075370193272835,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0742 (unadjusted contrast; not causal); copy_number: delta 0.181 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on RUNX1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RUNX1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:338755,OR2AG2,within_lineage,Bowel,precision_eligible,False,-0.2425473451887527,-0.3077426435019813,-0.1773520468755241,0.011792786995566507,0.19660083602092263,0.0026281298431810617,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0338 (unadjusted contrast; not causal); copy_number: delta -0.0188 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on OR2AG2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR2AG2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:10317,B3GALT5,within_lineage,Bowel,precision_eligible,False,-0.1861444723463594,-0.2410666601332662,-0.1312222845594526,0.011886330833575364,0.19816033139415887,0.0026281298431810617,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.14 (unadjusted contrast; not causal); copy_number: delta 0.0462 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on B3GALT5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb B3GALT5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7157,APC,TP53,ENTREZ:81832,NETO1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1829894838298278,-0.2386424293697036,-0.127336538289952,0.011077997298572423,0.19849230013918137,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.735 (unadjusted contrast; not causal); copy_number: delta -0.133 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on NETO1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NETO1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ENTREZ:84132,USP42,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1513855536369997,-0.2036351551142877,-0.0991359521597116,0.011142268426684023,0.19964389132552832,8.85093841555611e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.126 (unadjusted contrast; not causal); copy_number: delta -0.27 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in JAK2 is associated with stronger CRISPR dependency on USP42; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb USP42 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:23276,KLHL18,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.091002984347545,-0.1228524854305738,-0.0591534832645162,0.011504081174046261,0.2061267458079772,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.304 (unadjusted contrast; not causal); copy_number: delta -0.114 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on KLHL18; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KLHL18 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ENTREZ:654346,LGALS9C,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.158069190147703,-0.2122041610203939,-0.103934219275012,0.011712361897772083,0.20985865860888753,0.00027113314749751654,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.458 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRRIQ3 is associated with stronger CRISPR dependency on LGALS9C; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LGALS9C with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:4061,LY6E,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0848693231230817,-0.1145967667314233,-0.05514187951474,0.011712361897772083,0.20985865860888753,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.762 (unadjusted contrast; not causal); copy_number: delta -0.0914 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on LY6E; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LY6E with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:79863,RBFA,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3039240692079887,-0.4025742129182882,-0.2052739254976893,0.01177318702934684,0.2109485054419516,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.216 (unadjusted contrast; not causal); copy_number: delta -0.00647 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on RBFA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RBFA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ENTREZ:8390,OR1G1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1734585472162222,-0.2243490585668503,-0.122568035865594,0.01177318702934684,0.2109485054419516,9.720727815119711e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00398 (unadjusted contrast; not causal); copy_number: delta 0.108 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in KIF20B is associated with stronger CRISPR dependency on OR1G1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR1G1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:8289,APC,ARID1A,ENTREZ:10276,NET1,within_lineage,Bowel,precision_eligible,False,-0.1572047655979421,-0.207915928982638,-0.1064936022132461,0.013127763210602937,0.2188565962617274,0.033944264008440285,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.228 (unadjusted contrast; not causal); copy_number: delta 0.0561 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ARID1A is associated with stronger CRISPR dependency on NET1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NET1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:154664,TP53,ABCA13,ENTREZ:5326,PLAGL2,within_lineage,Uterus,precision_eligible,False,-0.3612290575964216,-0.4550527896757934,-0.2674053255170498,0.013394559099835392,0.22330442482759275,0.033944264008440285,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.301 (unadjusted contrast; not causal); copy_number: delta -0.428 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCA13 is associated with stronger CRISPR dependency on PLAGL2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PLAGL2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2956,TP53,MSH6,ENTREZ:412,STS,within_lineage,Bowel,precision_eligible,False,-0.2486106219833314,-0.3289769966150255,-0.1682442473516373,0.013414348859123057,0.22363434541566668,0.033944264008440285,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.24 (unadjusted contrast; not causal); copy_number: delta -0.2 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on STS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb STS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:27445,TP53,PCLO,ENTREZ:729956,SHISA7,within_lineage,Lung,precision_eligible,False,-0.1053569297365906,-0.1429455389399616,-0.0677683205332195,0.013414348859123057,0.22363434541566668,0.023576165448393346,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.259 (unadjusted contrast; not causal); copy_number: delta -0.0582 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PCLO is associated with stronger CRISPR dependency on SHISA7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SHISA7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:8242,KDM5C,within_lineage,Ovary/Fallopian Tube,precision_eligible,False,-0.3392623832852602,-0.4433519971072261,-0.2351727694632942,0.013427537800961963,0.22385422193787766,0.033944264008440285,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.798 (unadjusted contrast; not causal); copy_number: delta 0.2 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on KDM5C; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KDM5C with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:2793,GNGT2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1115383474120385,-0.1507674807116746,-0.0723092141124024,0.012513042715051804,0.224205022199322,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.3 (unadjusted contrast; not causal); copy_number: delta 0.0593 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on GNGT2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GNGT2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:6617,SNAPC1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.6255818425035979,-0.8294181264019249,-0.4217455586052709,0.012527616291762292,0.22446614726412883,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.078 (unadjusted contrast; not causal); copy_number: delta -0.0355 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on SNAPC1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SNAPC1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:3785,KCNQ2,within_lineage,Head and Neck,precision_eligible,False,-0.1215606264590947,-0.1629970659724575,-0.0801241869457319,0.013487368373851245,0.22485167407994264,0.02731070315051411,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.468 (unadjusted contrast; not causal); copy_number: delta 0.0396 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on KCNQ2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KCNQ2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:10056,FARSB,within_lineage,Lung,precision_eligible,False,-0.3340207789186634,-0.4533240331744775,-0.2147175246628492,0.013581889128589087,0.22642745590401653,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.195 (unadjusted contrast; not causal); copy_number: delta -0.018 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on FARSB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FARSB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:80731,TERT,THSD7B,ENTREZ:10494,STK25,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1770529453530737,-0.2311423299879351,-0.1229635607182122,0.012638071066018434,0.22644524345024916,0.035414683933877096,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0758 (unadjusted contrast; not causal); copy_number: delta -0.0119 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in THSD7B is associated with stronger CRISPR dependency on STK25; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb STK25 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:6899,TBX1,within_lineage,Lung,precision_eligible,False,-0.1049809416574613,-0.1425487540688448,-0.0674131292460777,0.014131897982252287,0.2355968066681528,7.372053965892916e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.13 (unadjusted contrast; not causal); copy_number: delta -0.21 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on TBX1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TBX1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ENTREZ:3973,LHCGR,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1407629027666391,-0.1910238875581864,-0.0905019179750919,0.013187272126129317,0.23628566665330714,8.811606588355312e-08,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0105 (unadjusted contrast; not causal); copy_number: delta -0.134 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ATRX is associated with stronger CRISPR dependency on LHCGR; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LHCGR with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ENTREZ:140890,SREK1,within_lineage,Skin,precision_eligible,False,-0.3205534234893338,-0.4241960831006586,-0.2169107638780091,0.01421004117326643,0.236899553566617,1.2795807582824207e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: GP1b-IX-V activation signalling (FDR=0.0321); GSEA: GLI3 is processed to GLI3R by the proteasome (FDR=0.0321); GSEA: GAB1 signalosome (FDR=0.0321),expression: delta 0.605 (unadjusted contrast; not causal); copy_number: delta 0.0468 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in BRAF is associated with stronger CRISPR dependency on SREK1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SREK1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:154664,TP53,ABCA13,ENTREZ:54516,MTRF1L,within_lineage,Lung,precision_eligible,False,-0.2747149001908423,-0.3731027501581465,-0.1763270502235381,0.01421004117326643,0.236899553566617,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0242 (unadjusted contrast; not causal); copy_number: delta -0.0992 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCA13 is associated with stronger CRISPR dependency on MTRF1L; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MTRF1L with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:284434,TP53,NWD1,ENTREZ:81168,OR8J3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1511408493420354,-0.2042342532399867,-0.0980474454440841,0.013300105145050655,0.23830737552845108,0.006172245171030115,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.000266 (unadjusted contrast; not causal); copy_number: delta 0.0212 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NWD1 is associated with stronger CRISPR dependency on OR8J3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR8J3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:26235,FBXL4,within_lineage,Bowel,precision_eligible,False,-0.2483695870784245,-0.3229848551924412,-0.1737543189644079,0.014616847857095447,0.24368154107896262,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.342 (unadjusted contrast; not causal); copy_number: delta 0.132 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on FBXL4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FBXL4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:472,ATM,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1983183982045555,-0.2685368161824083,-0.1280999802267028,0.013606561094212186,0.24379836316826994,4.996071779082237e-09,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,"ORA: p53-Dependent G1/S DNA damage checkpoint (FDR=1.92e-06); ORA: p53-Dependent G1 DNA Damage Response (FDR=1.92e-06); ORA: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (FDR=2e-06); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0413); GSEA: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (FDR=0.0413); GSEA: Vpu mediated degradation of CD4 (FDR=0.0413)",expression: delta -0.329 (unadjusted contrast; not causal); copy_number: delta 0.187 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on ATM; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ATM with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:10060,TP53,ABCC9,ENTREZ:5500,PPP1CB,within_lineage,Lung,precision_eligible,False,-0.3522498590901855,-0.4787793426098238,-0.2257203755705472,0.01463045270890733,0.24390835135215438,1.6138677555324986e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.126 (unadjusted contrast; not causal); copy_number: delta -0.0346 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCC9 is associated with stronger CRISPR dependency on PPP1CB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPP1CB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7157,KRAS,TP53,ENTREZ:1106,CHD2,within_lineage,Pancreas,precision_eligible,False,-0.1399721469122804,-0.1848447642137936,-0.0950995296107671,0.01463045270890733,0.24390835135215438,0.037857940705273076,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.178 (unadjusted contrast; not causal); copy_number: delta 0.189 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on CHD2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CHD2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:84893,FBH1,within_lineage,Bowel,precision_eligible,False,-0.1316267442187141,-0.1745695536097276,-0.0886839348277006,0.014660431922607376,0.24440814317226398,0.030361252568615382,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.31 (unadjusted contrast; not causal); copy_number: delta -0.0288 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on FBH1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FBH1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:23345,APC,SYNE1,ENTREZ:346288,SEPTIN14,within_lineage,Bowel,precision_eligible,False,-0.2360204313892254,-0.3085252603574386,-0.1635156024210121,0.014744809469196204,0.2458148247486373,0.03831634911764394,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00182 (unadjusted contrast; not causal); copy_number: delta -2.56 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on SEPTIN14; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SEPTIN14 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:11037,STON1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0718872456433511,-0.0972247948999319,-0.0465496963867703,0.013964187712130012,0.2502062118134987,9.322218911980652e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.255 (unadjusted contrast; not causal); copy_number: delta -0.0446 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on STON1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb STON1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:129684,TP53,CNTNAP5,ENTREZ:4659,PPP1R12A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.5363406297843409,-0.725849825925724,-0.3468314336429579,0.014020538113768648,0.2512158817505424,0.020782923856166372,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0968 (unadjusted contrast; not causal); copy_number: delta -0.0603 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CNTNAP5 is associated with stronger CRISPR dependency on PPP1R12A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPP1R12A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:23345,TP53,SYNE1,ENTREZ:57583,TMEM181,within_lineage,Lung,precision_eligible,False,-0.2131404370125736,-0.2899278856114345,-0.1363529884137127,0.015207261840414115,0.2535244970114773,0.0022582247839471313,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (FDR=0.0496); GSEA: mRNA Splicing - Minor Pathway (FDR=0.0496); GSEA: Transport of the SLBP Dependant Mature mRNA (FDR=0.0496),expression: delta 0.287 (unadjusted contrast; not causal); copy_number: delta 0.252 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on TMEM181; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TMEM181 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4741,TP53,NEFM,ENTREZ:10207,PATJ,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1750804982949964,-0.2330126626140103,-0.1171483339759824,0.014276631519205475,0.2558044881317863,0.04113617543184933,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 1.29 (unadjusted contrast; not causal); copy_number: delta -0.0273 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NEFM is associated with stronger CRISPR dependency on PATJ; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PATJ with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:2033,APC,EP300,ENTREZ:151011,SEPTIN10,within_lineage,Bowel,precision_eligible,False,-0.2904863319827626,-0.3801340114768266,-0.2008386524886986,0.01539334917487402,0.25662681078526767,0.023576165448393346,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.453 (unadjusted contrast; not causal); copy_number: delta -0.126 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on SEPTIN10; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SEPTIN10 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:79633,APC,FAT4,ENTREZ:151011,SEPTIN10,within_lineage,Bowel,precision_eligible,False,-0.2904863319827626,-0.3801340114768266,-0.2008386524886986,0.01539334917487402,0.25662681078526767,0.04058229643241895,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.494 (unadjusted contrast; not causal); copy_number: delta -0.127 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in FAT4 is associated with stronger CRISPR dependency on SEPTIN10; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SEPTIN10 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7273,APC,TTN,ENTREZ:390326,OR6C76,within_lineage,Bowel,precision_eligible,False,-0.1744835183740851,-0.228379968856244,-0.1205870678919262,0.015428972086875435,0.2572206902713986,0.007915600586225304,computational_hypothesis_with_context_annotations,unavailable,holdout_model_not_estimable,False,not established,expression: delta 0 (unadjusted contrast; not causal); copy_number: delta -0.0323 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on OR6C76; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR6C76 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ENTREZ:4804,NGFR,within_lineage,Lymphoid,precision_eligible,False,-0.1732120561506928,-0.2312921190159791,-0.1151319932854065,0.015428972086875435,0.2572206902713986,0.0004374327734731569,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.138 (unadjusted contrast; not causal); copy_number: delta -0.096 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CCND3 is associated with stronger CRISPR dependency on NGFR; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NGFR with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:118987,PDZD8,within_lineage,Head and Neck,precision_eligible,False,-0.1574891854638402,-0.2118560934795457,-0.1031222774481347,0.015428972086875435,0.2572206902713986,0.02731070315051411,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.554 (unadjusted contrast; not causal); copy_number: delta 0.00717 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on PDZD8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PDZD8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:114088,TRIM9,within_lineage,Lung,precision_eligible,False,-0.1493917659684853,-0.2033208477137473,-0.0954626842232233,0.015428972086875435,0.2572206902713986,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.249 (unadjusted contrast; not causal); copy_number: delta -0.209 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on TRIM9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TRIM9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:4089,TERT,SMAD4,ENTREZ:399687,MYO18A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.172053806929775,-0.2293615176254219,-0.1147460962341282,0.014914606214259668,0.2672355312381263,0.022292376166384142,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: ABC transporter disorders (FDR=0.0425); GSEA: p53-Independent G1/S DNA Damage Checkpoint (FDR=0.0425); GSEA: Mitochondrial ribosome-associated quality control (FDR=0.0425),expression: delta -0.354 (unadjusted contrast; not causal); copy_number: delta -0.0608 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in SMAD4 is associated with stronger CRISPR dependency on MYO18A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MYO18A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:56138,PCDHA11,within_lineage,Lung,precision_eligible,False,-0.1049861823001208,-0.1430074290446583,-0.0669649355555834,0.01620202270534967,0.2701084324086613,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.38 (unadjusted contrast; not causal); copy_number: delta -0.0258 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on PCDHA11; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PCDHA11 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9863,TP53,MAGI2,ENTREZ:1742,DLG4,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1911048481959418,-0.2594343622758518,-0.1227753341160318,0.015116055491652732,0.2708450401911821,0.01098138622656085,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.432 (unadjusted contrast; not causal); copy_number: delta -0.0319 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAGI2 is associated with stronger CRISPR dependency on DLG4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DLG4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ENTREZ:79705,LRRK1,within_lineage,Lymphoid,precision_eligible,False,-0.1755349062314716,-0.234605552116657,-0.1164642603462862,0.016366134093306298,0.2728443790585038,0.042829015238610046,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.98 (unadjusted contrast; not causal); copy_number: delta 0.128 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NRAS is associated with stronger CRISPR dependency on LRRK1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LRRK1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:2956,ENTREZ:27445,MSH6,PCLO,ENTREZ:64768,IPPK,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4345004979322029,-0.534972080897463,-0.334028914966943,0.015458663340975539,0.27698378695424414,0.04440509862391302,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.291 (unadjusted contrast; not causal); copy_number: delta 0.0725 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in MSH6, the presence of an annotated variant in PCLO is associated with stronger CRISPR dependency on IPPK; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb IPPK with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:84690,SPATA22,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1521453125664033,-0.2040236776087003,-0.1002669475241063,0.015458663340975539,0.27698378695424414,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0835 (unadjusted contrast; not causal); copy_number: delta 0.128 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on SPATA22; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SPATA22 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:57082,KNL1,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1996351115088553,-0.2680386203615041,-0.1312316026562065,0.01662999912388144,0.27724334646351684,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.199 (unadjusted contrast; not causal); copy_number: delta 0.0349 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on KNL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KNL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:26278,TP53,SACS,ENTREZ:55655,NLRP2,within_lineage,Bowel,precision_eligible,False,-0.1967832982356336,-0.2617501193111176,-0.1318164771601496,0.01662999912388144,0.27724334646351684,0.03727446385249296,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 2.1 (unadjusted contrast; not causal); copy_number: delta -0.0282 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SACS is associated with stronger CRISPR dependency on NLRP2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NLRP2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:341640,TP53,FREM2,ENTREZ:51704,GPRC5B,within_lineage,Bowel,precision_eligible,False,-0.1858441452396957,-0.247201620333523,-0.1244866701458683,0.01662999912388144,0.27724334646351684,0.042829015238610046,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.13 (unadjusted contrast; not causal); copy_number: delta -0.0721 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FREM2 is associated with stronger CRISPR dependency on GPRC5B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GPRC5B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2625,TP53,GATA3,ENTREZ:57670,KIAA1549,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2030863973439458,-0.2718885797814164,-0.1342842149064752,0.01565474225891544,0.2804970713847891,0.012794101052133685,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.418 (unadjusted contrast; not causal); copy_number: delta -0.0116 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in GATA3 is associated with stronger CRISPR dependency on KIAA1549; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KIAA1549 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:129684,TP53,CNTNAP5,ENTREZ:54555,DDX49,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4598595285303973,-0.6232827282839515,-0.2964363287768432,0.015712737020478585,0.28153620447973715,0.020782923856166372,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.277 (unadjusted contrast; not causal); copy_number: delta 0.0458 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CNTNAP5 is associated with stronger CRISPR dependency on DDX49; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DDX49 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:10973,TP53,ASCC3,ENTREZ:55295,KLHL26,within_lineage,Bowel,precision_eligible,False,-0.1437167438066553,-0.1912180188146449,-0.0962154687986656,0.01691539655863078,0.28200128657479345,0.029707939230177338,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0699 (unadjusted contrast; not causal); copy_number: delta 0.0359 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASCC3 is associated with stronger CRISPR dependency on KLHL26; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KLHL26 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:2956,APC,MSH6,ENTREZ:80167,ABHD18,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3557221388007519,-0.4666766960833077,-0.244767581518196,0.01576316889692785,0.28243982802169626,0.04511713822927242,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.544 (unadjusted contrast; not causal); copy_number: delta 0.0613 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on ABHD18; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ABHD18 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:472,APC,ATM,ENTREZ:23787,MTCH1,within_lineage,Bowel,precision_eligible,False,-0.1901942338258464,-0.2531112515324208,-0.1272772161192719,0.01706198188582245,0.28444505138502174,0.0006893549193769735,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.589 (unadjusted contrast; not causal); copy_number: delta -0.00866 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on MTCH1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MTCH1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5290,ENTREZ:2956,PIK3CA,MSH6,ENTREZ:83852,SETDB2,within_lineage,Bowel,precision_eligible,False,-0.3858278703547997,-0.4669578086941371,-0.3046979320154623,0.017096955975058503,0.28502811416614915,0.0045700336522369765,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.265 (unadjusted contrast; not causal); copy_number: delta -0.106 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PIK3CA, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on SETDB2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SETDB2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:23224,ENTREZ:10664,SYNE2,CTCF,ENTREZ:348013,TMEM255B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2655561348640447,-0.3070779709452649,-0.2240342987828245,0.016072859115733078,0.2879887663545462,0.04511713822927242,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.26 (unadjusted contrast; not causal); copy_number: delta 0.0331 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in SYNE2, the presence of an annotated variant in CTCF is associated with stronger CRISPR dependency on TMEM255B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TMEM255B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7015,TP53,TERT,ENTREZ:171568,POLR3H,within_lineage,Lung,precision_eligible,False,-0.3517094614821288,-0.4797535955194816,-0.2236653274447761,0.017406299528141284,0.2901852666846015,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.158 (unadjusted contrast; not causal); copy_number: delta 0.0677 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TERT is associated with stronger CRISPR dependency on POLR3H; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb POLR3H with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:7403,TTN,KDM6A,ENTREZ:23214,XPO6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2513146641232539,-0.3256683075274346,-0.1769610207190731,0.01641368108544152,0.294095514251489,0.0206885720925328,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.2 (unadjusted contrast; not causal); copy_number: delta 0.0595 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in KDM6A is associated with stronger CRISPR dependency on XPO6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb XPO6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:219285,TP53,SAMD9L,ENTREZ:79295,OR5H6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1721201795917402,-0.2319015934940901,-0.1123387656893903,0.016425607723804424,0.29430921225283135,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00646 (unadjusted contrast; not causal); copy_number: delta -0.0253 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SAMD9L is associated with stronger CRISPR dependency on OR5H6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR5H6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ENTREZ:90557,CCDC74A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1938046843718699,-0.2614259509540872,-0.1261834177896525,0.016470751079985246,0.2951180776427415,6.397730400898308e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: NoRC negatively regulates rRNA expression (FDR=0.0297); GSEA: Cellular Senescence (FDR=0.0297); GSEA: Cellular response to chemical stress (FDR=0.0297),expression: delta -0.492 (unadjusted contrast; not causal); copy_number: delta 0.0487 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on CCDC74A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CCDC74A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:3693,ITGB5,within_lineage,Bowel,precision_eligible,False,-0.4531367746662894,-0.6035481250869561,-0.3027254242456227,0.01772496411901277,0.29549781281972226,0.030361252568615382,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.715 (unadjusted contrast; not causal); copy_number: delta -0.0138 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on ITGB5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ITGB5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:55294,ENTREZ:1387,FBXW7,CREBBP,ENTREZ:140688,NOL4L,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2121290952921373,-0.2551334564202824,-0.1691247341639922,0.01666792444314274,0.298650972021074,0.04655264436766825,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.213 (unadjusted contrast; not causal); copy_number: delta -0.135 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in FBXW7, the presence of an annotated variant in CREBBP is associated with stronger CRISPR dependency on NOL4L; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NOL4L with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:129684,TP53,CNTNAP5,ENTREZ:55004,LAMTOR1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.251469218346548,-0.3412159416853189,-0.1617224950077771,0.01676717363086494,0.30042928980063005,0.020782923856166372,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.248 (unadjusted contrast; not causal); copy_number: delta -0.151 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CNTNAP5 is associated with stronger CRISPR dependency on LAMTOR1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LAMTOR1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4780,TP53,NFE2L2,ENTREZ:9197,SLC33A1,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.3858978678215306,-0.5190924376022894,-0.2527032980407719,0.01815879839271185,0.30273038480934894,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Sema4D in semaphorin signaling (FDR=0.0395); GSEA: Signaling by VEGF (FDR=0.0395); GSEA: Phase I - Functionalization of compounds (FDR=0.0395),expression: delta 0.0306 (unadjusted contrast; not causal); copy_number: delta 0.176 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NFE2L2 is associated with stronger CRISPR dependency on SLC33A1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC33A1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2956,KRAS,MSH6,ENTREZ:64746,ACBD3,within_lineage,Bowel,precision_eligible,False,-0.3820344232314765,-0.4995711216905483,-0.2644977247724047,0.01815879839271185,0.30273038480934894,0.04979686873093012,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.392 (unadjusted contrast; not causal); copy_number: delta -0.0724 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on ACBD3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ACBD3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7015,TP53,TERT,ENTREZ:6727,SRP14,within_lineage,Lung,precision_eligible,False,-0.2905896223981697,-0.3967613196807055,-0.1844179251156339,0.01815879839271185,0.30273038480934894,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.332 (unadjusted contrast; not causal); copy_number: delta 0.0623 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TERT is associated with stronger CRISPR dependency on SRP14; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SRP14 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:494197,SPANXN5,within_lineage,Lung,precision_eligible,False,-0.0644281302194153,-0.0878228760307872,-0.0410333844080434,0.018160343824476045,0.30275614913265686,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0541 (unadjusted contrast; not causal); copy_number: delta 0.248 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on SPANXN5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SPANXN5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ENTREZ:22943,DKK1,within_lineage,Head and Neck,precision_eligible,False,-0.0939817391070051,-0.1268578194343948,-0.0611056587796153,0.01820505185031193,0.30350148908151575,0.006938299567639482,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.755 (unadjusted contrast; not causal); copy_number: delta -0.1 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PIK3CA is associated with stronger CRISPR dependency on DKK1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DKK1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:79776,APC,ZFHX4,ENTREZ:387748,OR56B1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1617322199819352,-0.2106050940124835,-0.1128593459513869,0.017242502407834842,0.30894609114298616,0.0495305106159483,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00388 (unadjusted contrast; not causal); copy_number: delta -0.0577 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ZFHX4 is associated with stronger CRISPR dependency on OR56B1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR56B1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7157,APC,TP53,ENTREZ:55726,INTS13,within_lineage,Bowel,precision_eligible,False,-0.2531318468299807,-0.3375262537497011,-0.1687374399102603,0.018559025507116345,0.3094026824875608,0.0069196764854982966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.369 (unadjusted contrast; not causal); copy_number: delta 0.082 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on INTS13; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb INTS13 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:57492,TP53,ARID1B,ENTREZ:201965,RWDD4,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2454101632384559,-0.31769707986542,-0.1731232466114917,0.017390977528718456,0.3116064247270564,0.049774328660271774,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.323 (unadjusted contrast; not causal); copy_number: delta 0.0882 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ARID1B is associated with stronger CRISPR dependency on RWDD4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RWDD4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ENTREZ:403239,OR2T27,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1827400776889312,-0.2417574072108176,-0.1237227481670449,0.017394895539713563,0.31167662649669303,0.0004093442336740012,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.000842 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KIAA2026 is associated with stronger CRISPR dependency on OR2T27; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR2T27 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2196,KRAS,FAT2,ENTREZ:79934,COQ8B,within_lineage,Bowel,precision_eligible,False,-0.1665100463393466,-0.2179895234167301,-0.115030569261963,0.018761179502341668,0.31277284803716415,0.033546274223613934,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.221 (unadjusted contrast; not causal); copy_number: delta 0.0929 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on COQ8B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb COQ8B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:54969,HPF1,within_lineage,Lung,precision_eligible,False,-0.1182740969532222,-0.1616229803971397,-0.0749252135093048,0.018761179502341668,0.31277284803716415,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.248 (unadjusted contrast; not causal); copy_number: delta -0.134 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on HPF1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HPF1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:642658,SCX,within_lineage,Lung,precision_eligible,False,-0.1097602767564001,-0.1498233590037283,-0.0696971945090719,0.019469568929931246,0.3245826054545458,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.49 (unadjusted contrast; not causal); copy_number: delta -0.0873 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on SCX; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SCX with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:123016,TTC8,within_lineage,Bowel,precision_eligible,False,-0.2138964884081059,-0.2802538692857945,-0.1475391075304173,0.019571317599420636,0.3262788858582495,0.0026281298431810617,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.62 (unadjusted contrast; not causal); copy_number: delta 0.0765 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on TTC8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TTC8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:196528,APC,ARID2,ENTREZ:6648,SOD2,within_lineage,Bowel,precision_eligible,False,-1.0798139943510985,-1.4420230686856557,-0.7176049200165413,0.019913194807121927,0.33197841599271566,0.033944264008440285,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.66 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ARID2 is associated with stronger CRISPR dependency on SOD2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SOD2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:55294,ENTREZ:8085,FBXW7,KMT2D,ENTREZ:144195,SLC2A14,within_lineage,Bowel,precision_eligible,False,-0.403610968329204,-0.4959534386683747,-0.3112684979900333,0.019913194807121927,0.33197841599271566,0.004913700751351219,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.974 (unadjusted contrast; not causal); copy_number: delta 0.102 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in FBXW7, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on SLC2A14; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC2A14 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:55337,SHFL,within_lineage,Lung,precision_eligible,False,-0.0978773092426527,-0.1339366096860355,-0.0618180087992699,0.02040582893502813,0.3401912567262258,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.481 (unadjusted contrast; not causal); copy_number: delta 0.0514 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on SHFL; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SHFL with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:29072,TP53,SETD2,ENTREZ:9856,KIAA0319,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1462209681628986,-0.1983313027064752,-0.094110633619322,0.019173326213291358,0.3435420246839648,0.0001948870953143044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0986 (unadjusted contrast; not causal); copy_number: delta 0.0713 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SETD2 is associated with stronger CRISPR dependency on KIAA0319; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KIAA0319 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:285601,GPR150,within_lineage,Lung,precision_eligible,False,-0.1266388819873291,-0.173326643604323,-0.0799511203703351,0.020653451839649506,0.34431944712640805,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.365 (unadjusted contrast; not causal); copy_number: delta -0.012 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on GPR150; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GPR150 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:127602,DNAH14,within_lineage,Lung,precision_eligible,False,-0.1138143254957379,-0.1557996970696681,-0.0718289539218078,0.020865946616280214,0.3478620067224885,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.377 (unadjusted contrast; not causal); copy_number: delta 0.0221 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on DNAH14; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DNAH14 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:11200,CHEK2,within_lineage,Skin,precision_eligible,False,-0.3190408792325351,-0.4259547077765993,-0.212127050688471,0.020933175837279334,0.34898280378754454,1.9536731784932713e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (FDR=0.0376); GSEA: PCP/CE pathway (FDR=0.0376); GSEA: Activation of NF-kappaB in B cells (FDR=0.0376),expression: delta -0.273 (unadjusted contrast; not causal); copy_number: delta -0.11 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on CHEK2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CHEK2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:144535,TP53,CFAP54,ENTREZ:57139,RGL3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1832480705563802,-0.2494374093160896,-0.1170587317966708,0.019655702813960417,0.35218510686024035,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.43 (unadjusted contrast; not causal); copy_number: delta 0.129 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CFAP54 is associated with stronger CRISPR dependency on RGL3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RGL3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:26052,DNM3,within_lineage,Lung,precision_eligible,False,-0.1120360771386172,-0.1534092846161449,-0.0706628696610895,0.02121262670299322,0.35364160699044944,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.253 (unadjusted contrast; not causal); copy_number: delta 0.222 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on DNM3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DNM3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:83990,TTN,BRIP1,ENTREZ:6007,RHD,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3556629589308616,-0.4706258628134253,-0.2407000550482978,0.019838767999575246,0.3554652150592897,0.011264070744576977,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.091 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on RHD; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RHD with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ENTREZ:9989,PPP4R1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1677391585846019,-0.2266666324589342,-0.1088116847102695,0.019838767999575246,0.3554652150592897,0.002769700795120968,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00412 (unadjusted contrast; not causal); copy_number: delta 0.0725 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in NRAS is associated with stronger CRISPR dependency on PPP4R1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPP4R1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:56926,NCLN,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1238469308605624,-0.168551590858342,-0.0791422708627827,0.019848304070530027,0.3556360795763219,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.144 (unadjusted contrast; not causal); copy_number: delta -0.0229 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on NCLN; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NCLN with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:6510,SLC1A5,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2052425692645437,-0.2793853639309021,-0.1310997745981854,0.019903625949637918,0.35662732074890835,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.149 (unadjusted contrast; not causal); copy_number: delta -0.00678 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on SLC1A5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC1A5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:85315,PAQR8,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.123994985805189,-0.1687753869598752,-0.0792145846505027,0.019903625949637918,0.35662732074890835,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.335 (unadjusted contrast; not causal); copy_number: delta 0.15 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on PAQR8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PAQR8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:22943,DKK1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1006017382032655,-0.1354874376675804,-0.0657160387389506,0.019903625949637918,0.35662732074890835,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.152 (unadjusted contrast; not causal); copy_number: delta -0.0732 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on DKK1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DKK1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:23345,TP53,SYNE1,ENTREZ:51496,CTDSPL2,within_lineage,Lung,precision_eligible,False,-0.2236234703430326,-0.3063062934153258,-0.1409406472707395,0.02145653704780734,0.35770790427222304,0.0022582247839471313,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (FDR=0.0496); GSEA: mRNA Splicing - Minor Pathway (FDR=0.0496); GSEA: Transport of the SLBP Dependant Mature mRNA (FDR=0.0496),expression: delta -0.0182 (unadjusted contrast; not causal); copy_number: delta -0.0339 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on CTDSPL2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CTDSPL2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:26278,TP53,SACS,ENTREZ:94027,CGB7,within_lineage,Bowel,precision_eligible,False,-0.3117031140045385,-0.4092561430942695,-0.2141500849148074,0.02147313363139905,0.3579845905390443,0.03727446385249296,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0134 (unadjusted contrast; not causal); copy_number: delta -0.0215 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SACS is associated with stronger CRISPR dependency on CGB7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CGB7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7179,TP53,TPTE,ENTREZ:5036,PA2G4,within_lineage,Lung,precision_eligible,False,-0.196784312274144,-0.269630066332526,-0.123938558215762,0.021538277906989513,0.3590706288985837,0.00445850481036875,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0314 (unadjusted contrast; not causal); copy_number: delta -0.0501 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on PA2G4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PA2G4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:5684,PSMA3,within_lineage,Lung,precision_eligible,False,-0.5134859041108816,-0.7037339822319291,-0.3232378259898341,0.02162166639558193,0.3604608216136691,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0739 (unadjusted contrast; not causal); copy_number: delta 0.245 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on PSMA3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PSMA3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:10556,RPP30,within_lineage,Lung,precision_eligible,False,-0.2429301923985516,-0.3329049327282751,-0.152955452068828,0.02162166639558193,0.3604608216136691,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.225 (unadjusted contrast; not causal); copy_number: delta 0.129 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on RPP30; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RPP30 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8289,TP53,ARID1A,ENTREZ:388960,C2orf78,within_lineage,Bowel,precision_eligible,False,-0.2090010727561523,-0.2797431464992634,-0.1382589990130412,0.02162166639558193,0.3604608216136691,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0517 (unadjusted contrast; not causal); copy_number: delta -0.0784 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ARID1A is associated with stronger CRISPR dependency on C2orf78; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C2orf78 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:57683,APC,ZDBF2,ENTREZ:23397,NCAPH,within_lineage,Bowel,precision_eligible,False,-0.2730726664275115,-0.3655455645952276,-0.1805997682597954,0.02168940328632729,0.361590082182439,0.029971056485900996,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.217 (unadjusted contrast; not causal); copy_number: delta -0.0559 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ZDBF2 is associated with stronger CRISPR dependency on NCAPH; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NCAPH with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:339479,BRINP3,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.0718968999027539,-0.0971395773099258,-0.0466542224955821,0.021806628829981984,0.3635443818653032,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.665 (unadjusted contrast; not causal); copy_number: delta 0.0248 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on BRINP3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BRINP3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:10350,TTN,ABCA9,ENTREZ:4650,MYO9B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2698150197974722,-0.3511617923331772,-0.1884682472617672,0.020388464401642287,0.3653145136539535,0.03131051898723206,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.232 (unadjusted contrast; not causal); copy_number: delta -0.0559 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in ABCA9 is associated with stronger CRISPR dependency on MYO9B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MYO9B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:6416,TTN,MAP2K4,ENTREZ:4650,MYO9B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2698150197974722,-0.3511617923331772,-0.1884682472617672,0.020388464401642287,0.3653145136539535,0.03131051898723206,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.291 (unadjusted contrast; not causal); copy_number: delta -0.0101 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in MAP2K4 is associated with stronger CRISPR dependency on MYO9B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MYO9B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:154664,TP53,ABCA13,ENTREZ:29935,RPA4,within_lineage,Lung,precision_eligible,False,-0.1098225329579828,-0.1505866948003579,-0.0690583711156078,0.02203051830680163,0.3672769056813932,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.000163 (unadjusted contrast; not causal); copy_number: delta -0.103 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCA13 is associated with stronger CRISPR dependency on RPA4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RPA4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ENTREZ:81472,OR2C3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3058711213509473,-0.3972881163296004,-0.2144541263722942,0.020525327021343198,0.3677667778543617,0.004468750801494793,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00996 (unadjusted contrast; not causal); copy_number: delta -0.046 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on OR2C3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR2C3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:472,APC,ATM,ENTREZ:50833,TAS2R16,within_lineage,Bowel,precision_eligible,False,-0.1376484836696006,-0.1844080208384706,-0.0908889465007306,0.02260068475073928,0.37678230924641654,0.0006893549193769735,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0 (unadjusted contrast; not causal); copy_number: delta -0.0394 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on TAS2R16; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TAS2R16 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:94025,TTN,MUC16,ENTREZ:79641,ROGDI,within_lineage,Lung,precision_eligible,False,-0.1119290874713769,-0.1464341359218552,-0.0774240390208985,0.02260068475073928,0.37678230924641654,0.0015207222607744688,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.519 (unadjusted contrast; not causal); copy_number: delta 0.0339 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in MUC16 is associated with stronger CRISPR dependency on ROGDI; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ROGDI with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8085,TP53,KMT2D,ENTREZ:54863,TOR4A,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.16038109535908,-0.2168617656043787,-0.1039004251137812,0.02275916353158709,0.37942435313459744,0.004149554560875475,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.568 (unadjusted contrast; not causal); copy_number: delta -0.0623 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on TOR4A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TOR4A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:1130,LYST,within_lineage,Lung,precision_eligible,False,-0.0864205078366766,-0.1185641069140305,-0.0542769087593227,0.02275916353158709,0.37942435313459744,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.09 (unadjusted contrast; not causal); copy_number: delta 0.0335 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on LYST; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LYST with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:283297,OR10A4,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1372981740908807,-0.1837921907908652,-0.0908041573908962,0.021331012284187215,0.38220280962977643,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00158 (unadjusted contrast; not causal); copy_number: delta 0.0266 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on OR10A4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR10A4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7179,TP53,TPTE,ENTREZ:23645,PPP1R15A,within_lineage,Lung,precision_eligible,False,-0.1323136526659811,-0.1815832420543188,-0.0830440632776434,0.023127600338646952,0.38556666574620324,0.00445850481036875,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.139 (unadjusted contrast; not causal); copy_number: delta -0.146 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on PPP1R15A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPP1R15A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:4089,TERT,SMAD4,ENTREZ:27166,PRELID1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.5944889574751553,-0.797905301504781,-0.3910726134455295,0.021668884236006936,0.3882566999731017,0.022292376166384142,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: ABC transporter disorders (FDR=0.0425); GSEA: p53-Independent G1/S DNA Damage Checkpoint (FDR=0.0425); GSEA: Mitochondrial ribosome-associated quality control (FDR=0.0425),expression: delta -0.595 (unadjusted contrast; not causal); copy_number: delta -0.03 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in SMAD4 is associated with stronger CRISPR dependency on PRELID1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRELID1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:129684,TP53,CNTNAP5,ENTREZ:79142,PHF23,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1966212884372188,-0.2679410011866129,-0.1253015756878247,0.021668884236006936,0.3882566999731017,0.020782923856166372,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.218 (unadjusted contrast; not causal); copy_number: delta 0.0157 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CNTNAP5 is associated with stronger CRISPR dependency on PHF23; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PHF23 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ENTREZ:10490,VTI1B,within_lineage,Bowel,precision_eligible,False,-0.3565889574728886,-0.4781302028422647,-0.2350477121035125,0.023392928878299996,0.38999003171860736,0.002137397301756624,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.124 (unadjusted contrast; not causal); copy_number: delta 0.0306 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on VTI1B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb VTI1B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:23219,FBXO28,within_lineage,Bowel,precision_eligible,False,-0.2869182628158178,-0.3354924115851553,-0.2383441140464802,0.023392928878299996,0.38999003171860736,0.001040615355027238,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.414 (unadjusted contrast; not causal); copy_number: delta -0.0157 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on FBXO28; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FBXO28 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:10944,C11orf58,within_lineage,Lung,precision_eligible,False,-0.1178743452619243,-0.1618097899457884,-0.0739389005780602,0.023392928878299996,0.38999003171860736,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.15 (unadjusted contrast; not causal); copy_number: delta 0.045 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on C11orf58; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C11orf58 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ENTREZ:7799,PRDM2,within_lineage,Head and Neck,precision_eligible,False,-0.0963519118012726,-0.130783980511517,-0.0619198430910282,0.023392928878299996,0.38999003171860736,0.006938299567639482,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.17 (unadjusted contrast; not causal); copy_number: delta -0.114 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PIK3CA is associated with stronger CRISPR dependency on PRDM2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRDM2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:5005,ORM2,within_lineage,CNS/Brain,precision_eligible,False,-0.1122893225475336,-0.1514890053157477,-0.0730896397793195,0.02355481391593548,0.3926888622622592,0.005991560059067487,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0177 (unadjusted contrast; not causal); copy_number: delta 0.0295 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RB1 is associated with stronger CRISPR dependency on ORM2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ORM2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:29072,TP53,SETD2,ENTREZ:84248,FYTTD1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1109820539475704,-0.1509522061201638,-0.071011901774977,0.022181035372561747,0.3974332735336279,0.0001948870953143044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.146 (unadjusted contrast; not causal); copy_number: delta -0.0196 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SETD2 is associated with stronger CRISPR dependency on FYTTD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FYTTD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:29072,TP53,SETD2,ENTREZ:64324,NSD1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2050176967792966,-0.2788810591803818,-0.1311543343782113,0.02231747811438946,0.3998780144856924,0.0001948870953143044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.238 (unadjusted contrast; not causal); copy_number: delta 0.0222 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SETD2 is associated with stronger CRISPR dependency on NSD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NSD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ENTREZ:148738,HJV,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2336963305396897,-0.3175471582184858,-0.1498455028608937,0.022538863362135467,0.40384473029701057,6.397730400898308e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: NoRC negatively regulates rRNA expression (FDR=0.0297); GSEA: Cellular Senescence (FDR=0.0297); GSEA: Cellular response to chemical stress (FDR=0.0297),expression: delta -0.021 (unadjusted contrast; not causal); copy_number: delta 0.22 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on HJV; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HJV with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:10912,GADD45G,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1235688353435455,-0.1673131693362683,-0.0798245013508226,0.024225527016716895,0.40387050714343825,0.0016335234270482293,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.102 (unadjusted contrast; not causal); copy_number: delta -0.0885 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on GADD45G; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GADD45G with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ENTREZ:143384,CACUL1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1274204876334878,-0.1732852059345078,-0.0815557693324677,0.022863051024720485,0.4096534295671879,0.00027113314749751654,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.194 (unadjusted contrast; not causal); copy_number: delta 0.00704 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRRIQ3 is associated with stronger CRISPR dependency on CACUL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CACUL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:6502,SKP2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.6059681680796146,-0.8314449960754619,-0.3804913400837674,0.022895066949020663,0.41022708149037834,2.6913039776546925e-08,computational_hypothesis_with_context_annotations,unavailable,internally_replicated,False,GSEA: RHO GTPases Activate WASPs and WAVEs (FDR=0.0317); GSEA: APC truncation mutants have impaired AXIN binding (FDR=0.0317); GSEA: APC/C-mediated degradation of cell cycle proteins (FDR=0.0317),expression: delta 0.87 (unadjusted contrast; not causal); copy_number: delta 0.0485 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RB1 is associated with stronger CRISPR dependency on SKP2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SKP2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:219285,TP53,SAMD9L,ENTREZ:3052,HCCS,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3039286611214595,-0.4133629691404035,-0.1944943531025155,0.023318748785729468,0.41781848813446204,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.112 (unadjusted contrast; not causal); copy_number: delta 0.011 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SAMD9L is associated with stronger CRISPR dependency on HCCS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HCCS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:119679,OR52J3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0990238711021563,-0.1347076891197178,-0.0633400530845948,0.023318748785729468,0.41781848813446204,5.265940490010591e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00111 (unadjusted contrast; not causal); copy_number: delta -0.0884 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on OR52J3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR52J3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ENTREZ:90678,LRSAM1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0862948155460673,-0.1173697275331473,-0.0552199035589873,0.023318748785729468,0.41781848813446204,6.397730400898308e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: NoRC negatively regulates rRNA expression (FDR=0.0297); GSEA: Cellular Senescence (FDR=0.0297); GSEA: Cellular response to chemical stress (FDR=0.0297),expression: delta -0.111 (unadjusted contrast; not causal); copy_number: delta 0.027 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on LRSAM1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LRSAM1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:83990,TTN,BRIP1,ENTREZ:8209,GATD3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2286412660685224,-0.3037722500608306,-0.1535102820762142,0.023352503064701435,0.4184232873858167,0.011264070744576977,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.425 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on GATD3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GATD3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:10051,TP53,SMC4,ENTREZ:2512,FTL,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2098077285084074,-0.2846277385236603,-0.1349877184931545,0.023424709912972557,0.4197170684739365,0.012375844226358942,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.225 (unadjusted contrast; not causal); copy_number: delta -0.0754 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SMC4 is associated with stronger CRISPR dependency on FTL; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FTL with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:4784,NFIX,within_lineage,Lung,precision_eligible,False,-0.1121868851320146,-0.1542147726388184,-0.0701589976252108,0.025196274307011105,0.42005410555055234,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.284 (unadjusted contrast; not causal); copy_number: delta -0.00159 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on NFIX; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NFIX with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:10841,FTCD,within_lineage,Bowel,precision_eligible,False,-0.2827722615307109,-0.3728894550428311,-0.1926550680185906,0.025277622344641676,0.42141028133943453,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0361 (unadjusted contrast; not causal); copy_number: delta -0.00328 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on FTCD; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FTCD with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:2033,APC,EP300,ENTREZ:440021,KRTAP5-2,within_lineage,Bowel,precision_eligible,False,-0.1901527313156767,-0.2553988862742598,-0.1249065763570936,0.025277622344641676,0.42141028133943453,0.023576165448393346,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0508 (unadjusted contrast; not causal); copy_number: delta -0.00538 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on KRTAP5-2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KRTAP5-2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8085,TP53,KMT2D,ENTREZ:3043,HBB,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.081198207302424,-0.1100436462313971,-0.0523527683734509,0.025277622344641676,0.42141028133943453,0.004149554560875475,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 1.06 (unadjusted contrast; not causal); copy_number: delta 0.372 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on HBB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HBB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9699,TP53,RIMS2,ENTREZ:29980,DONSON,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4570201009196822,-0.6263354724589669,-0.2877047293803974,0.023549462505378448,0.42195234876400867,0.04511713822927242,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00235 (unadjusted contrast; not causal); copy_number: delta -0.0277 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on DONSON; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DONSON with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:5925,RB1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1539230310668891,-0.2114235246638444,-0.0964225374699339,0.023848577665588455,0.427311806304609,2.6913039776546925e-08,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,GSEA: RHO GTPases Activate WASPs and WAVEs (FDR=0.0317); GSEA: APC truncation mutants have impaired AXIN binding (FDR=0.0317); GSEA: APC/C-mediated degradation of cell cycle proteins (FDR=0.0317),expression: delta -1.09 (unadjusted contrast; not causal); copy_number: delta 0.0302 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RB1 is associated with stronger CRISPR dependency on RB1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RB1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5290,ENTREZ:7273,PIK3CA,TTN,ENTREZ:90529,STPG1,within_lineage,Bowel,precision_eligible,False,-0.2050295222775083,-0.2512981214614077,-0.1587609230936089,0.025864190281866335,0.43118911876648136,0.0133977149806943,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.206 (unadjusted contrast; not causal); copy_number: delta 0.144 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PIK3CA, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on STPG1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb STPG1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ENTREZ:9847,C2CD5,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0852186151977512,-0.1166758003158408,-0.0537614300796617,0.024256487553730884,0.43462061580913386,3.5036725300167764e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0547 (unadjusted contrast; not causal); copy_number: delta 0.0276 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PPP1R9A is associated with stronger CRISPR dependency on C2CD5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C2CD5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5728,TP53,PTEN,ENTREZ:138240,C9orf57,within_lineage,Lung,precision_eligible,False,-0.2536954970882035,-0.3356474312608683,-0.1717435629155387,0.026261841167820606,0.4378184674227795,0.006748505338180818,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00552 (unadjusted contrast; not causal); copy_number: delta -0.102 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PTEN is associated with stronger CRISPR dependency on C9orf57; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C9orf57 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:79776,TP53,ZFHX4,ENTREZ:92675,DTD1,within_lineage,Lung,precision_eligible,False,-0.1681183085791582,-0.2313408450422952,-0.1048957721160212,0.02629438959929976,0.43836109138795226,0.0009414773712833701,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.192 (unadjusted contrast; not causal); copy_number: delta -0.103 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ZFHX4 is associated with stronger CRISPR dependency on DTD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DTD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:57683,APC,ZDBF2,ENTREZ:6635,SNRPE,within_lineage,Bowel,precision_eligible,False,-0.552167428015221,-0.7314228608948252,-0.3729119951356168,0.026417887738122273,0.44041996325163146,0.029971056485900996,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.145 (unadjusted contrast; not causal); copy_number: delta -0.0591 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ZDBF2 is associated with stronger CRISPR dependency on SNRPE; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SNRPE with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:2739,GLO1,within_lineage,Bowel,precision_eligible,False,-0.5480384496230049,-0.6436495338736242,-0.4524273653723855,0.026417887738122273,0.44041996325163146,0.001040615355027238,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0126 (unadjusted contrast; not causal); copy_number: delta 0.0105 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on GLO1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GLO1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:57084,SLC17A6,within_lineage,Lung,precision_eligible,False,-0.1196519193161261,-0.1647796136445515,-0.0745242249877007,0.026417887738122273,0.44041996325163146,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.867 (unadjusted contrast; not causal); copy_number: delta 0.0569 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on SLC17A6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC17A6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:146223,CMTM4,within_lineage,Lung,precision_eligible,False,-0.1115658164986599,-0.1535806702722915,-0.0695509627250282,0.026417887738122273,0.44041996325163146,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0119 (unadjusted contrast; not causal); copy_number: delta 0.00117 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on CMTM4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CMTM4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:126374,WTIP,within_lineage,Lung,precision_eligible,False,-0.111265042324662,-0.153160895907311,-0.0693691887420129,0.026417887738122273,0.44041996325163146,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0273 (unadjusted contrast; not causal); copy_number: delta -0.188 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on WTIP; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb WTIP with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5728,TP53,PTEN,ENTREZ:727800,RNF208,within_lineage,Lung,precision_eligible,False,-0.1024498950601432,-0.1410987444195644,-0.063801045700722,0.026417887738122273,0.44041996325163146,0.006748505338180818,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0751 (unadjusted contrast; not causal); copy_number: delta -0.0877 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PTEN is associated with stronger CRISPR dependency on RNF208; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RNF208 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8085,TP53,KMT2D,ENTREZ:79675,FASTKD1,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.0924708191897331,-0.1254803553329742,-0.0594612830464921,0.026417887738122273,0.44041996325163146,0.004149554560875475,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.112 (unadjusted contrast; not causal); copy_number: delta 0.0414 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on FASTKD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FASTKD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7157,KRAS,TP53,ENTREZ:1718,DHCR24,within_lineage,Bowel,precision_eligible,False,-0.1785929158616687,-0.2360643062802358,-0.1211215254431015,0.026504858941376185,0.44186988440054165,0.005309233117520593,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00674 (unadjusted contrast; not causal); copy_number: delta -0.0233 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on DHCR24; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DHCR24 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2956,KRAS,MSH6,ENTREZ:339230,CCDC137,within_lineage,Bowel,precision_eligible,False,-0.4748629412691944,-0.6277566912438831,-0.3219691912945057,0.026572025595944383,0.44298963840320454,0.04979686873093012,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.775 (unadjusted contrast; not causal); copy_number: delta -0.00841 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on CCDC137; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CCDC137 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7179,TP53,TPTE,ENTREZ:97,ACYP1,within_lineage,Lung,precision_eligible,False,-0.1252227105907411,-0.1725019855794775,-0.0779434356020047,0.026572025595944383,0.44298963840320454,0.00445850481036875,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.153 (unadjusted contrast; not causal); copy_number: delta 0.16 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on ACYP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ACYP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:9883,POM121,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0851084178491784,-0.1163289402820852,-0.0538878954162716,0.024784252646617058,0.4440769556507806,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.28 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on POM121; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb POM121 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:23168,RTF1,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1348788931743387,-0.1832377830103919,-0.0865200033382854,0.026854773818118686,0.4477034127538984,2.350672500648786e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0728 (unadjusted contrast; not causal); copy_number: delta 0.0628 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KRAS is associated with stronger CRISPR dependency on RTF1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RTF1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9863,TP53,MAGI2,ENTREZ:83862,TMEM120A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3105083547108842,-0.4176388424037947,-0.2033778670179737,0.025196771266693826,0.4514683430597512,0.01098138622656085,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.365 (unadjusted contrast; not causal); copy_number: delta 0.111 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAGI2 is associated with stronger CRISPR dependency on TMEM120A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TMEM120A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ENTREZ:8581,LY6D,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1372285007210349,-0.1880137803168823,-0.0864432211251876,0.025263118570807663,0.4526571345575868,3.5036725300167764e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.739 (unadjusted contrast; not causal); copy_number: delta 0.0055 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PPP1R9A is associated with stronger CRISPR dependency on LY6D; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LY6D with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ENTREZ:3070,HELLS,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0795427905070277,-0.1089827727897462,-0.0501028082243092,0.02526846476511711,0.45275292609615403,3.5036725300167764e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0523 (unadjusted contrast; not causal); copy_number: delta 0.109 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PPP1R9A is associated with stronger CRISPR dependency on HELLS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HELLS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:203430,RTL3,within_lineage,Ovary/Fallopian Tube,precision_eligible,False,-0.1531410100519355,-0.2038432078042932,-0.1024388122995778,0.02716345501167114,0.45284952289216884,0.033944264008440285,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0479 (unadjusted contrast; not causal); copy_number: delta 0.163 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on RTL3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RTL3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7157,APC,TP53,ENTREZ:1173,AP2M1,within_lineage,Bowel,precision_eligible,False,-0.7217726182846781,-0.972311295135001,-0.4712339414343551,0.027248553446996424,0.45426822260541844,0.0069196764854982966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0992 (unadjusted contrast; not causal); copy_number: delta 0.151 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on AP2M1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AP2M1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:159195,USP54,within_lineage,Bowel,precision_eligible,False,-0.2254573953227678,-0.2982729539362658,-0.1526418367092698,0.027248553446996424,0.45426822260541844,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.294 (unadjusted contrast; not causal); copy_number: delta 0.0466 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on USP54; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb USP54 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:94025,TP53,MUC16,ENTREZ:55509,BATF3,within_lineage,Lung,precision_eligible,False,-0.0988607291087848,-0.1362699195508644,-0.0614515386667053,0.027248553446996424,0.45426822260541844,0.037857940705273076,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.429 (unadjusted contrast; not causal); copy_number: delta -0.0299 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MUC16 is associated with stronger CRISPR dependency on BATF3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BATF3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:2033,APC,EP300,ENTREZ:1850,DUSP8,within_lineage,Bowel,precision_eligible,False,-0.1926884324698395,-0.2596113086086843,-0.1257655563309946,0.027390280925329632,0.45663100086452885,0.023576165448393346,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.242 (unadjusted contrast; not causal); copy_number: delta -0.00538 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on DUSP8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DUSP8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:91409,CCDC74B,within_lineage,Bowel,precision_eligible,False,-0.4327708713455486,-0.5727655018405449,-0.2927762408505523,0.027587823679313506,0.45992429112727223,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.272 (unadjusted contrast; not causal); copy_number: delta -0.0374 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on CCDC74B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CCDC74B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ENTREZ:29926,GMPPA,within_lineage,Bowel,precision_eligible,False,-0.1764393503272152,-0.2377715803630525,-0.115107120291378,0.027613770728024036,0.4603568616019771,0.002137397301756624,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.309 (unadjusted contrast; not causal); copy_number: delta -0.135 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on GMPPA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GMPPA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:79837,PIP4K2C,within_lineage,Bowel,precision_eligible,False,-0.1744366149663347,-0.2350860566122663,-0.113787173320403,0.027655819716035052,0.46105787199077725,0.04276064596537308,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,not established,expression: delta -0.139 (unadjusted contrast; not causal); copy_number: delta -0.0341 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on PIP4K2C; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PIP4K2C with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:2995,GYPC,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0864568346183594,-0.1180496868441544,-0.0548639823925645,0.025859396155913525,0.46334106110127277,5.265940490010591e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.302 (unadjusted contrast; not causal); copy_number: delta 0.00585 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on GYPC; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GYPC with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ENTREZ:7709,ZBTB17,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1547665093947517,-0.2121219999145008,-0.0974110188750026,0.025916733984337977,0.4643684234612927,3.5036725300167764e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0148 (unadjusted contrast; not causal); copy_number: delta -0.0552 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PPP1R9A is associated with stronger CRISPR dependency on ZBTB17; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZBTB17 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:23345,TP53,SYNE1,ENTREZ:2595,GANC,within_lineage,Lung,precision_eligible,False,-0.138052831381103,-0.1904847618903624,-0.0856209008718436,0.028520586044302382,0.47547463226669995,0.0022582247839471313,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (FDR=0.0496); GSEA: mRNA Splicing - Minor Pathway (FDR=0.0496); GSEA: Transport of the SLBP Dependant Mature mRNA (FDR=0.0496),expression: delta -0.152 (unadjusted contrast; not causal); copy_number: delta -0.0314 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on GANC; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GANC with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:10388,SYCP2,within_lineage,Lung,precision_eligible,False,-0.0840691289885011,-0.1160071486076062,-0.052131109369396,0.0285526072592471,0.4760084668582094,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.528 (unadjusted contrast; not causal); copy_number: delta 0.0293 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on SYCP2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SYCP2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5290,ENTREZ:7157,PIK3CA,TP53,ENTREZ:7157,TP53,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.4831235455977382,-0.6527685976271038,-0.3134784935683725,0.026619581793633804,0.4769618439645538,0.01082749358525764,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Activation of NF-kappaB in B cells (FDR=0.0325); GSEA: AUF1 (hnRNP D0) binds and destabilizes mRNA (FDR=0.0325); GSEA: rRNA modification in the nucleus and cytosol (FDR=0.0325),expression: delta -0.174 (unadjusted contrast; not causal); copy_number: delta 0.0145 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PIK3CA, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on TP53; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TP53 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1387,TP53,CREBBP,ENTREZ:9185,REPS2,within_lineage,Lymphoid,precision_eligible,False,-0.1076430358152613,-0.1459137076419606,-0.0693723639885619,0.028640416331823605,0.47747235635992374,0.042991223440851316,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.325 (unadjusted contrast; not causal); copy_number: delta 0.279 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CREBBP is associated with stronger CRISPR dependency on REPS2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb REPS2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:116987,AGAP1,within_lineage,Bowel,precision_eligible,False,-0.1568241904065933,-0.2115678678289267,-0.1020805129842598,0.028928415388150698,0.48227366882901435,0.04276064596537308,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,not established,expression: delta 0.187 (unadjusted contrast; not causal); copy_number: delta -0.0544 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on AGAP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AGAP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:55294,ENTREZ:8085,FBXW7,KMT2D,ENTREZ:22944,KIN,within_lineage,Bowel,precision_eligible,False,-0.8885363964125346,-1.1064545403742363,-0.6706182524508327,0.029141139708501535,0.48582005521237565,0.004913700751351219,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.378 (unadjusted contrast; not causal); copy_number: delta 0.0894 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in FBXW7, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on KIN; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KIN with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:136895,C7orf31,within_lineage,Bowel,precision_eligible,False,-0.2840675531081614,-0.3765177716597246,-0.1916173345565981,0.029141139708501535,0.48582005521237565,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.186 (unadjusted contrast; not causal); copy_number: delta -0.319 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on C7orf31; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C7orf31 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:6667,SP1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2465788136366878,-0.3376074303470163,-0.1555501969263594,0.027247855080937917,0.48821906009775046,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.259 (unadjusted contrast; not causal); copy_number: delta 0.102 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on SP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:1954,MEGF8,within_lineage,Lung,precision_eligible,False,-0.1386619409774727,-0.1914942132276388,-0.0858296687273065,0.029397166104059166,0.49008834255013367,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.551 (unadjusted contrast; not causal); copy_number: delta 0.15 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on MEGF8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MEGF8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:54894,KRAS,RNF43,ENTREZ:56658,TRIM39,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1313494945462899,-0.1778478743238892,-0.0848511147686906,0.027580856535162238,0.49418568229643933,0.0004051008582123968,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: ABC transporter disorders (FDR=0.0331); GSEA: rRNA processing in the nucleus and cytosol (FDR=0.0331); GSEA: ABC-family protein mediated transport (FDR=0.0331),expression: delta -0.0917 (unadjusted contrast; not causal); copy_number: delta -0.00802 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in RNF43 is associated with stronger CRISPR dependency on TRIM39; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TRIM39 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ENTREZ:222389,BEND7,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2385729118038762,-0.3256365598847116,-0.1515092637230408,0.027611818427407727,0.49474044838301895,1.2538043515616061e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.161 (unadjusted contrast; not causal); copy_number: delta 0.0323 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CNTNAP2 is associated with stronger CRISPR dependency on BEND7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BEND7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ENTREZ:142684,RAB40A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.125182712489032,-0.1694676285049958,-0.0808977964730682,0.027748178664790606,0.49718371104468617,0.0023227175473404184,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.441 (unadjusted contrast; not causal); copy_number: delta -0.143 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TET2 is associated with stronger CRISPR dependency on RAB40A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RAB40A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9863,TP53,MAGI2,ENTREZ:116369,SLC26A8,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1070083896975863,-0.14683424823222,-0.0671825311629526,0.028102853553437633,0.5035386714722563,0.01098138622656085,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.043 (unadjusted contrast; not causal); copy_number: delta -0.0484 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAGI2 is associated with stronger CRISPR dependency on SLC26A8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC26A8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:100506658,OCLN,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.090430486916701,-0.1238926034415581,-0.0569683703918438,0.028102853553437633,0.5035386714722563,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.569 (unadjusted contrast; not causal); copy_number: delta -0.0174 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on OCLN; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OCLN with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ENTREZ:4650,MYO9B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2326933535951814,-0.3136608315312155,-0.1517258756591473,0.028225245515107685,0.5057316546745149,0.0005460658986232966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0484 (unadjusted contrast; not causal); copy_number: delta -0.036 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAP2K4 is associated with stronger CRISPR dependency on MYO9B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MYO9B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:2956,ENTREZ:288,MSH6,ANK3,ENTREZ:3356,HTR2A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2082092461666624,-0.2603341815442231,-0.1560843107891017,0.02824219081171721,0.5060352755195027,0.027888668955665313,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0449 (unadjusted contrast; not causal); copy_number: delta -0.0629 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in MSH6, the presence of an annotated variant in ANK3 is associated with stronger CRISPR dependency on HTR2A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HTR2A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ENTREZ:654502,IQCJ,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1484207092567529,-0.2037635132878754,-0.0930779052256303,0.02824219081171721,0.5060352755195027,3.5036725300167764e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0203 (unadjusted contrast; not causal); copy_number: delta 0.133 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PPP1R9A is associated with stronger CRISPR dependency on IQCJ; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb IQCJ with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:6166,RPL36AL,within_lineage,Bowel,precision_eligible,False,-0.5986780110601476,-0.7944382174406778,-0.4029178046796174,0.030446606925480603,0.5075838627289943,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.299 (unadjusted contrast; not causal); copy_number: delta 0.0384 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on RPL36AL; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RPL36AL with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ENTREZ:4804,NGFR,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1732120561506928,-0.2312921190159791,-0.1151319932854065,0.0284545594248199,0.5098404339209723,0.0006582060541288882,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.22 (unadjusted contrast; not causal); copy_number: delta -0.128 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CCND3 is associated with stronger CRISPR dependency on NGFR; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NGFR with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:441670,OR4M1,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.112102017370876,-0.1522069177424644,-0.0719971169992877,0.03066535313725203,0.5112306417411853,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0 (unadjusted contrast; not causal); copy_number: delta -0.32 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on OR4M1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR4M1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7179,TP53,TPTE,ENTREZ:133396,IL31RA,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0953376793110731,-0.1302766375982841,-0.0603987210238621,0.028790274608729606,0.5158556799306887,0.004875566248171198,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.154 (unadjusted contrast; not causal); copy_number: delta 0.0449 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TPTE is associated with stronger CRISPR dependency on IL31RA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb IL31RA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:80148,SLC66A2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.166183567003349,-0.2281261558651152,-0.1042409781415827,0.029163036366326833,0.5225347155609764,2.5311773649289936e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.654 (unadjusted contrast; not causal); copy_number: delta 0.178 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on SLC66A2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC66A2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:23345,APC,SYNE1,ENTREZ:10845,CLPX,within_lineage,Bowel,precision_eligible,False,-0.2324809088216223,-0.3142558015951295,-0.1507060160481151,0.03135177326499266,0.5226741428428444,0.03831634911764394,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.259 (unadjusted contrast; not causal); copy_number: delta -0.0497 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on CLPX; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CLPX with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:54538,ROBO4,within_lineage,Bowel,precision_eligible,False,-0.4139374471136993,-0.4895660985431201,-0.3383087956842784,0.03159478097532435,0.5267253920537986,0.001040615355027238,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.279 (unadjusted contrast; not causal); copy_number: delta -0.00107 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on ROBO4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ROBO4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:4544,MTNR1B,within_lineage,Bowel,precision_eligible,False,-0.3224569901491708,-0.4284404639115876,-0.216473516386754,0.03159478097532435,0.5267253920537986,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00194 (unadjusted contrast; not causal); copy_number: delta 0.0139 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on MTNR1B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MTNR1B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:7273,KRAS,TTN,ENTREZ:4354,MPP1,within_lineage,Bowel,precision_eligible,False,-0.2244153254384737,-0.2981214299345974,-0.15070922094235,0.03159478097532435,0.5267253920537986,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.184 (unadjusted contrast; not causal); copy_number: delta -0.279 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on MPP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MPP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7399,TP53,USH2A,ENTREZ:83715,ESPN,within_lineage,Lung,precision_eligible,False,-0.1652526362678192,-0.2286079266570105,-0.1018973458786278,0.03159478097532435,0.5267253920537986,0.0007464256197534772,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: tRNA processing in the nucleus (FDR=0.0472); GSEA: snRNP Assembly (FDR=0.0472); GSEA: mRNA Splicing - Major Pathway (FDR=0.0472),expression: delta 0.371 (unadjusted contrast; not causal); copy_number: delta 0.0303 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in USH2A is associated with stronger CRISPR dependency on ESPN; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ESPN with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8085,TP53,KMT2D,ENTREZ:84681,HINT2,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1038800287287649,-0.1417183104640112,-0.0660417469935186,0.03159478097532435,0.5267253920537986,0.004149554560875475,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.219 (unadjusted contrast; not causal); copy_number: delta -0.0404 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on HINT2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HINT2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:220992,ZNF485,within_lineage,Lung,precision_eligible,False,-0.0910113685603022,-0.1259069860225039,-0.0561157510981005,0.03159478097532435,0.5267253920537986,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.422 (unadjusted contrast; not causal); copy_number: delta 0.073 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on ZNF485; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF485 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:154664,TP53,ABCA13,ENTREZ:23169,SLC35D1,within_lineage,Lung,precision_eligible,False,-0.0849336775232164,-0.1174687182263621,-0.0523986368200707,0.03159478097532435,0.5267253920537986,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.146 (unadjusted contrast; not causal); copy_number: delta -0.0643 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCA13 is associated with stronger CRISPR dependency on SLC35D1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC35D1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:672,TP53,BRCA1,ENTREZ:113510,HELQ,within_lineage,Breast,precision_eligible,False,-0.2332276612486765,-0.312451129265547,-0.154004193231806,0.03184281936911196,0.5308605091895754,0.0007728967039296098,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: RNA Polymerase I Transcription (FDR=0.043); GSEA: Polymerase switching on the C-strand of the telomere (FDR=0.043); GSEA: Processing of SMDT1 (FDR=0.043),expression: delta 0.409 (unadjusted contrast; not causal); copy_number: delta 0.15 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRCA1 is associated with stronger CRISPR dependency on HELQ; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HELQ with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:8348,H2BC17,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.125711721777754,-0.1696680105226687,-0.0817554330328394,0.030091657339676687,0.5391734732704996,3.113720411768672e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.493 (unadjusted contrast; not causal); copy_number: delta -0.0455 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on H2BC17; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb H2BC17 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:472,BRAF,ATM,ENTREZ:1215,CMA1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1455353235709902,-0.1955396273262441,-0.0955310198157362,0.03057201264186495,0.547780338414589,0.01903738331268079,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0079 (unadjusted contrast; not causal); copy_number: delta 0.0521 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on CMA1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CMA1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1029,TP53,CDKN2A,ENTREZ:8572,PDLIM4,within_lineage,Lymphoid,precision_eligible,False,-0.1529322930697822,-0.208055044042057,-0.0978095420975074,0.0331460747951374,0.5525874433232734,0.0069196764854982966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0139 (unadjusted contrast; not causal); copy_number: delta -0.0404 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CDKN2A is associated with stronger CRISPR dependency on PDLIM4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PDLIM4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ENTREZ:7143,TNR,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1323568650762269,-0.1801669250080477,-0.0845468051444061,0.030849012013773942,0.5527435317595097,0.0003541895182373382,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0478 (unadjusted contrast; not causal); copy_number: delta 0.127 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CDH1 is associated with stronger CRISPR dependency on TNR; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TNR with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ENTREZ:5176,SERPINF1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1088111952407286,-0.1491934534469005,-0.0684289370345567,0.030849012013773942,0.5527435317595097,0.0001041167154611385,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.758 (unadjusted contrast; not causal); copy_number: delta 0.118 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KCNT2 is associated with stronger CRISPR dependency on SERPINF1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SERPINF1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:7552,ZNF711,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0982730568511303,-0.1347895195770344,-0.0617565941252263,0.031306641137202426,0.5609431959110529,9.322218911980652e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0677 (unadjusted contrast; not causal); copy_number: delta -0.0808 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on ZNF711; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF711 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:4703,ENTREZ:1387,NEB,CREBBP,ENTREZ:647174,SERPINE3,within_lineage,Bowel,precision_eligible,False,-0.2067516313069437,-0.2450867936986765,-0.1684164689152109,0.03389329850398027,0.565044617857876,0.042829015238610046,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0397 (unadjusted contrast; not causal); copy_number: delta -0.52 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in NEB, the presence of an annotated variant in CREBBP is associated with stronger CRISPR dependency on SERPINE3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SERPINE3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ENTREZ:200894,ARL13B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3192140387449011,-0.4313324350741491,-0.2070956424156531,0.03178213863854787,0.5694630204071875,0.0005460658986232966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.489 (unadjusted contrast; not causal); copy_number: delta 0.015 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAP2K4 is associated with stronger CRISPR dependency on ARL13B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ARL13B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:266812,NAP1L5,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1309915177436878,-0.1780652366982142,-0.0839177987891614,0.03178213863854787,0.5694630204071875,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.397 (unadjusted contrast; not causal); copy_number: delta 0.0125 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on NAP1L5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NAP1L5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:22826,DNAJC8,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1974601388225565,-0.2712070779505645,-0.1237131996945485,0.03192079349961957,0.5719473974617971,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.348 (unadjusted contrast; not causal); copy_number: delta 0.00773 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on DNAJC8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DNAJC8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:50837,TAS2R7,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1179649061633005,-0.162207861685151,-0.0737219506414501,0.03192079349961957,0.5719473974617971,2.5311773649289936e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00449 (unadjusted contrast; not causal); copy_number: delta -0.00586 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on TAS2R7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TAS2R7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:10286,BCAS2,within_lineage,Bowel,precision_eligible,False,-0.3759747159213237,-0.5094241713610764,-0.242525260481571,0.03453193016357152,0.5756914240990362,0.030361252568615382,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0781 (unadjusted contrast; not causal); copy_number: delta -0.0028 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on BCAS2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BCAS2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:408187,SPINK14,within_lineage,Lung,precision_eligible,False,-0.1963198611587297,-0.2720345356156979,-0.1206051867017616,0.03453193016357152,0.5756914240990362,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0236 (unadjusted contrast; not causal); copy_number: delta -0.151 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on SPINK14; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SPINK14 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:288,APC,ANK3,ENTREZ:7314,UBB,within_lineage,Bowel,precision_eligible,False,-0.2894050908851458,-0.3869650821315949,-0.1918450996386967,0.03454954624959283,0.575985106774769,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.109 (unadjusted contrast; not causal); copy_number: delta 0.181 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ANK3 is associated with stronger CRISPR dependency on UBB; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb UBB with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ENTREZ:4893,NRAS,within_lineage,Lymphoid,precision_eligible,False,-1.2881247679233456,-1.7541198108633926,-0.8221297249832986,0.03469677645554044,0.5784396225383212,0.042829015238610046,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.896 (unadjusted contrast; not causal); copy_number: delta -0.00818 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NRAS is associated with stronger CRISPR dependency on NRAS; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NRAS with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2196,KRAS,FAT2,ENTREZ:84441,MAML2,within_lineage,Bowel,precision_eligible,False,-0.1157632559202679,-0.154173600749411,-0.0773529110911247,0.03496681510745629,0.5829415121039158,0.033546274223613934,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.323 (unadjusted contrast; not causal); copy_number: delta 0.0184 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on MAML2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAML2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2625,TP53,GATA3,ENTREZ:63933,MCUR1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1381136635824314,-0.1875378224843656,-0.0886895046804972,0.0326196800032994,0.5844698404551274,0.012794101052133685,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0155 (unadjusted contrast; not causal); copy_number: delta -0.138 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in GATA3 is associated with stronger CRISPR dependency on MCUR1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MCUR1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:341640,APC,FREM2,ENTREZ:23435,TARDBP,within_lineage,Bowel,precision_eligible,False,-0.4558441031346059,-0.6180581345702455,-0.2936300716989662,0.03533268463469997,0.589041024878778,0.0007464256197534772,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.544 (unadjusted contrast; not causal); copy_number: delta 0.132 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in FREM2 is associated with stronger CRISPR dependency on TARDBP; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TARDBP with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8085,TP53,KMT2D,ENTREZ:55253,TYW1,within_lineage,Lung,precision_eligible,False,-0.1202491095570693,-0.1667292573540091,-0.0737689617601295,0.03533268463469997,0.589041024878778,0.011352010325071224,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.146 (unadjusted contrast; not causal); copy_number: delta 0.0364 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on TYW1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TYW1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:341640,TP53,FREM2,ENTREZ:158158,RASEF,within_lineage,Bowel,precision_eligible,False,-0.1056050208484655,-0.1431867149067732,-0.0680233267901578,0.03533268463469997,0.589041024878778,0.042829015238610046,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.464 (unadjusted contrast; not causal); copy_number: delta -0.0407 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FREM2 is associated with stronger CRISPR dependency on RASEF; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RASEF with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:8085,ENTREZ:2261,KMT2D,FGFR3,ENTREZ:9441,MED26,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3321577577491595,-0.4319717199870353,-0.2323437955112838,0.03295306793551217,0.5904433874528403,0.049774328660271774,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.32 (unadjusted contrast; not causal); copy_number: delta 0.0995 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KMT2D, the presence of an annotated variant in FGFR3 is associated with stronger CRISPR dependency on MED26; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MED26 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:3093,UBE2K,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2033515351630737,-0.279633385519605,-0.1270696848065424,0.03295306793551217,0.5904433874528403,4.996071779082237e-09,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,"ORA: p53-Dependent G1/S DNA damage checkpoint (FDR=1.92e-06); ORA: p53-Dependent G1 DNA Damage Response (FDR=1.92e-06); ORA: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (FDR=2e-06); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0413); GSEA: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (FDR=0.0413); GSEA: Vpu mediated degradation of CD4 (FDR=0.0413)",expression: delta 0.0306 (unadjusted contrast; not causal); copy_number: delta -0.0244 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on UBE2K; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb UBE2K with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ENTREZ:341276,OR10A2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1454172338470114,-0.1917573162442267,-0.0990771514497961,0.03295306793551217,0.5904433874528403,6.664590789067346e-11,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00872 (unadjusted contrast; not causal); copy_number: delta -0.0661 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ASXL2 is associated with stronger CRISPR dependency on OR10A2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR10A2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ENTREZ:11200,CHEK2,within_lineage,Skin,precision_eligible,False,-0.3097028829356553,-0.4190352744637925,-0.200370491407518,0.035529923795827874,0.5923292538604759,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.177 (unadjusted contrast; not causal); copy_number: delta -0.0779 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on CHEK2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CHEK2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ENTREZ:11319,ECD,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3387764103806261,-0.4642203864782731,-0.2133324342829791,0.03350336657307062,0.6003034767260621,0.001983635476460049,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.12 (unadjusted contrast; not causal); copy_number: delta 0.177 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KIF18A is associated with stronger CRISPR dependency on ECD; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ECD with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ENTREZ:1116,CHI3L1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.102515856384545,-0.1408054569193161,-0.0642262558497738,0.03350336657307062,0.6003034767260621,0.0001041167154611385,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.619 (unadjusted contrast; not causal); copy_number: delta -0.069 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KCNT2 is associated with stronger CRISPR dependency on CHI3L1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CHI3L1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7157,APC,TP53,ENTREZ:55726,INTS13,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2531318468299807,-0.3375262537497011,-0.1687374399102603,0.033827658825292095,0.6061140500026101,0.01458340201106983,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.405 (unadjusted contrast; not causal); copy_number: delta 0.164 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on INTS13; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb INTS13 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:4089,TERT,SMAD4,ENTREZ:4038,LRP4,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1853789110200145,-0.2511075009394467,-0.1196503211005824,0.033827658825292095,0.6061140500026101,0.022292376166384142,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: ABC transporter disorders (FDR=0.0425); GSEA: p53-Independent G1/S DNA Damage Checkpoint (FDR=0.0425); GSEA: Mitochondrial ribosome-associated quality control (FDR=0.0425),expression: delta -0.753 (unadjusted contrast; not causal); copy_number: delta -0.00588 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in SMAD4 is associated with stronger CRISPR dependency on LRP4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LRP4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:170261,ZCCHC12,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1264247358704265,-0.1738493003470588,-0.0790001713937943,0.033827658825292095,0.6061140500026101,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.313 (unadjusted contrast; not causal); copy_number: delta -0.0868 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on ZCCHC12; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZCCHC12 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:83990,TTN,BRIP1,ENTREZ:55756,INTS9,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2844850931875189,-0.3810412552428572,-0.1879289311321806,0.03396894408848137,0.6086455578293742,0.011264070744576977,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.293 (unadjusted contrast; not causal); copy_number: delta 0.0635 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on INTS9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb INTS9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:79066,METTL16,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2607204509714952,-0.3585859546856995,-0.1628549472572909,0.03396894408848137,0.6086455578293742,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.322 (unadjusted contrast; not causal); copy_number: delta 0.0222 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on METTL16; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb METTL16 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ENTREZ:25989,ULK3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2498104832912837,-0.3303532902885472,-0.1692676762940202,0.034052928220595385,0.6101503608284374,9.720727815119711e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.317 (unadjusted contrast; not causal); copy_number: delta -0.0425 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in KIF20B is associated with stronger CRISPR dependency on ULK3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ULK3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:51298,THEG,within_lineage,Lung,precision_eligible,False,-0.1609591450431045,-0.2233436878425591,-0.0985746022436498,0.03670195704846539,0.6118685465992902,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 1.4 (unadjusted contrast; not causal); copy_number: delta 0.121 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on THEG; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb THEG with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:4124,MAN2A1,within_lineage,Bowel,precision_eligible,False,-0.4580380569129123,-0.5445221388728053,-0.3715539749530193,0.036751857450689554,0.6127004501008746,0.001040615355027238,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.759 (unadjusted contrast; not causal); copy_number: delta 0.277 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on MAN2A1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAN2A1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:2956,APC,MSH6,ENTREZ:57535,ELAPOR1,within_lineage,Bowel,precision_eligible,False,-0.2164454999422866,-0.2937620802060867,-0.1391289196784866,0.036751857450689554,0.6127004501008746,0.023576165448393346,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.386 (unadjusted contrast; not causal); copy_number: delta 0.112 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in MSH6 is associated with stronger CRISPR dependency on ELAPOR1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ELAPOR1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:154664,TP53,ABCA13,ENTREZ:220972,MARCHF8,within_lineage,Lung,precision_eligible,False,-0.1274955651802381,-0.1766839458719075,-0.0783071844885686,0.03699132519121692,0.6166926834894214,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.105 (unadjusted contrast; not causal); copy_number: delta 0.0477 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ABCA13 is associated with stronger CRISPR dependency on MARCHF8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MARCHF8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:100287238,USP17L13,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1916569195081724,-0.262914917370273,-0.1203989216460719,0.03546431519360326,0.6354391778508889,9.322218911980652e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00211 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on USP17L13; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb USP17L13 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:79568,MAIP1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1726909667211779,-0.2379910648421113,-0.1073908686002445,0.035570154399028525,0.6373355736310604,2.5311773649289936e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00267 (unadjusted contrast; not causal); copy_number: delta 0.0538 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on MAIP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAIP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:11200,CHEK2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1744092261413206,-0.240262642892347,-0.1085558093902941,0.03582911597409219,0.6419755710328178,4.996071779082237e-09,computational_hypothesis_with_context_annotations,unavailable,inconclusive,False,"ORA: p53-Dependent G1/S DNA damage checkpoint (FDR=1.92e-06); ORA: p53-Dependent G1 DNA Damage Response (FDR=1.92e-06); ORA: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (FDR=2e-06); GSEA: APC/C:Cdc20 mediated degradation of Securin (FDR=0.0413); GSEA: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (FDR=0.0413); GSEA: Vpu mediated degradation of CD4 (FDR=0.0413)",expression: delta 0.0167 (unadjusted contrast; not causal); copy_number: delta -0.00578 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in TP53 is associated with stronger CRISPR dependency on CHEK2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CHEK2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:10385,BTN2A2,within_lineage,Lung,precision_eligible,False,-0.0868655785199918,-0.1206679360915885,-0.0530632209483951,0.03851463251713631,0.6420881641256051,0.02738257774108158,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,"GSEA: Transport to the Golgi and subsequent modification (FDR=0.0462); GSEA: Truncations of AMER1 destabilize the destruction complex (FDR=0.0462); GSEA: Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (FDR=0.0462)",expression: delta 0.385 (unadjusted contrast; not causal); copy_number: delta 0.12 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RB1 is associated with stronger CRISPR dependency on BTN2A2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb BTN2A2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:5925,RB1,within_lineage,CNS/Brain,precision_eligible,False,-0.221525511025261,-0.3027688778898558,-0.1402821441606662,0.038853848227026797,0.6477433236889019,0.005991560059067487,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.69 (unadjusted contrast; not causal); copy_number: delta 0.182 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RB1 is associated with stronger CRISPR dependency on RB1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RB1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:83858,ATAD3B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2621794221475508,-0.3553047761460512,-0.1690540681490504,0.03620944631479561,0.6487902183110464,3.113720411768672e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.195 (unadjusted contrast; not causal); copy_number: delta -0.106 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on ATAD3B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ATAD3B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:81832,NETO1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0994718358986547,-0.1356088662972008,-0.0633348055001087,0.03624893002523181,0.6494976758316869,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.203 (unadjusted contrast; not causal); copy_number: delta -0.08 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on NETO1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NETO1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:220992,ZNF485,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1117176729586878,-0.1514202196295919,-0.0720151262877836,0.036411651078838383,0.6524132638518791,3.113720411768672e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.364 (unadjusted contrast; not causal); copy_number: delta -0.0991 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on ZNF485; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF485 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ENTREZ:159090,PABIR2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0657182341036073,-0.0896015986172372,-0.0418348695899775,0.036411651078838383,0.6524132638518791,2.6759323136671476e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.393 (unadjusted contrast; not causal); copy_number: delta -0.0297 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MLLT10 is associated with stronger CRISPR dependency on PABIR2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PABIR2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:2033,KRAS,EP300,ENTREZ:8771,TNFRSF6B,within_lineage,Bowel,precision_eligible,False,-0.289907197409057,-0.3873267118549011,-0.1924876829632129,0.03917848708703787,0.6531554685285442,0.0026281298431810617,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 1.26 (unadjusted contrast; not causal); copy_number: delta -0.33 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on TNFRSF6B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TNFRSF6B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7015,TP53,TERT,ENTREZ:148867,SLC30A7,within_lineage,Lung,precision_eligible,False,-0.1574704833650264,-0.2188455548228628,-0.0960954119071901,0.03917848708703787,0.6531554685285442,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.462 (unadjusted contrast; not causal); copy_number: delta -0.0791 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TERT is associated with stronger CRISPR dependency on SLC30A7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC30A7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:3845,ENTREZ:23345,KRAS,SYNE1,ENTREZ:84331,MCRIP2,within_lineage,Bowel,precision_eligible,False,-0.269013836207929,-0.35947226258289,-0.178555409832968,0.039398654599560295,0.6568259424413546,0.0003772536524379831,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.631 (unadjusted contrast; not causal); copy_number: delta -0.0398 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in KRAS, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on MCRIP2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MCRIP2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ENTREZ:613211,DEFB134,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1069393959078384,-0.146867842135286,-0.0670109496803909,0.036814349414319616,0.6596286942873235,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0149 (unadjusted contrast; not causal); copy_number: delta -0.0445 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RSPH4A is associated with stronger CRISPR dependency on DEFB134; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DEFB134 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:29072,TP53,SETD2,ENTREZ:10267,RAMP1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1011566966798876,-0.1389664153104128,-0.0633469780493625,0.036814349414319616,0.6596286942873235,0.0001948870953143044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -1.01 (unadjusted contrast; not causal); copy_number: delta 0.0853 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SETD2 is associated with stronger CRISPR dependency on RAMP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RAMP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:55294,ENTREZ:7273,FBXW7,TTN,ENTREZ:9455,HOMER2,within_lineage,Bowel,precision_eligible,False,-0.2225735748218517,-0.2799458229697791,-0.1652013266739243,0.03962528714804002,0.6606041967689718,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.411 (unadjusted contrast; not causal); copy_number: delta 0.178 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in FBXW7, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on HOMER2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HOMER2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4089,TP53,SMAD4,ENTREZ:4084,MXD1,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.1018764999001805,-0.1397347704980596,-0.0640182293023015,0.03974444224431502,0.6625906645609047,0.025328394647393473,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.245 (unadjusted contrast; not causal); copy_number: delta 0.0293 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SMAD4 is associated with stronger CRISPR dependency on MXD1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MXD1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:8085,APC,KMT2D,ENTREZ:81930,KIF18A,within_lineage,Bowel,precision_eligible,False,-1.3363097272574676,-1.817976017711051,-0.854643436803884,0.04024688696286699,0.6709670603830925,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.3 (unadjusted contrast; not causal); copy_number: delta -0.0815 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in KMT2D is associated with stronger CRISPR dependency on KIF18A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb KIF18A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:53353,TP53,LRP1B,ENTREZ:10650,PRELID3A,within_lineage,Lung,precision_eligible,False,-0.0874589744859609,-0.1216381325890696,-0.0532798163828521,0.04030862605934956,0.6719963300534608,4.767316068721396e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.139 (unadjusted contrast; not causal); copy_number: delta 0.174 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in LRP1B is associated with stronger CRISPR dependency on PRELID3A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PRELID3A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ENTREZ:64777,RMND5B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1658640452689805,-0.222646202165923,-0.109081888372038,0.0378234309644609,0.6777091209670957,6.664590789067346e-11,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.166 (unadjusted contrast; not causal); copy_number: delta -0.037 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ASXL2 is associated with stronger CRISPR dependency on RMND5B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RMND5B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:163747,LEXM,within_lineage,Lung,precision_eligible,False,-0.1083387845704058,-0.1507121653972558,-0.0659654037435558,0.040736480859818514,0.6791292165797234,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0826 (unadjusted contrast; not causal); copy_number: delta -0.00311 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on LEXM; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb LEXM with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4763,TP53,NF1,ENTREZ:3449,IFNA16,within_lineage,Lung,precision_eligible,False,-0.0727022830889791,-0.101150254285727,-0.0442543118922311,0.040973025002796246,0.6830727098593661,0.0001635001541704906,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.018 (unadjusted contrast; not causal); copy_number: delta -0.0421 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NF1 is associated with stronger CRISPR dependency on IFNA16; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb IFNA16 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:5290,ENTREZ:7273,PIK3CA,TTN,ENTREZ:10082,GPC6,within_lineage,Bowel,precision_eligible,False,-0.2717907040356301,-0.3388463709488343,-0.2047350371224259,0.04122785698806076,0.6873210848505119,0.0133977149806943,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.193 (unadjusted contrast; not causal); copy_number: delta -0.164 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in PIK3CA, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on GPC6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GPC6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:10350,TTN,ABCA9,ENTREZ:2815,GP9,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1466950137235503,-0.1938287540802032,-0.0995612733668974,0.038658123395901314,0.6926648946651743,0.03131051898723206,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0386 (unadjusted contrast; not causal); copy_number: delta 0.0576 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in ABCA9 is associated with stronger CRISPR dependency on GP9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GP9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:6416,TTN,MAP2K4,ENTREZ:2815,GP9,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1466950137235503,-0.1938287540802032,-0.0995612733668974,0.038658123395901314,0.6926648946651743,0.03131051898723206,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0443 (unadjusted contrast; not causal); copy_number: delta -0.028 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in MAP2K4 is associated with stronger CRISPR dependency on GP9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb GP9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ENTREZ:4499,MT1M,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1816442895709364,-0.2501011891396397,-0.113187390002233,0.0387209139572799,0.6937899574918887,0.0001041167154611385,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.32 (unadjusted contrast; not causal); copy_number: delta -0.0979 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNA2 is associated with stronger CRISPR dependency on MT1M; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MT1M with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:79776,TP53,ZFHX4,ENTREZ:239,ALOX12,within_lineage,Lung,precision_eligible,False,-0.1095813883245484,-0.1525106426364892,-0.0666521340126077,0.041662384107884816,0.6945652074708298,0.0009414773712833701,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.011 (unadjusted contrast; not causal); copy_number: delta -0.124 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ZFHX4 is associated with stronger CRISPR dependency on ALOX12; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ALOX12 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:324,TP53,APC,ENTREZ:115572,TENT5B,within_lineage,Bowel,precision_eligible,False,-0.188500486054551,-0.2567065176906839,-0.1202944544184181,0.0418962989736445,0.6984648673377777,0.030361252568615382,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.929 (unadjusted contrast; not causal); copy_number: delta -0.0567 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in APC is associated with stronger CRISPR dependency on TENT5B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TENT5B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:29072,TP53,SETD2,ENTREZ:54439,RBM27,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2487351483992516,-0.3420752424438953,-0.1553950543546079,0.039089606508205026,0.7003960822728309,0.0001948870953143044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0461 (unadjusted contrast; not causal); copy_number: delta 0.032 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SETD2 is associated with stronger CRISPR dependency on RBM27; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RBM27 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7273,TP53,TTN,ENTREZ:57805,CCAR2,within_lineage,Ovary/Fallopian Tube,precision_eligible,False,-0.2051168851461813,-0.2763106981069829,-0.1339230721853797,0.04226145840365732,0.7045525418839585,0.033944264008440285,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.707 (unadjusted contrast; not causal); copy_number: delta 0.275 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on CCAR2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CCAR2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:159371,SLC35G1,within_lineage,Lung,precision_eligible,False,-0.1111276385189292,-0.1547341530722575,-0.067521123965601,0.042296364633815545,0.7051344733675025,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.247 (unadjusted contrast; not causal); copy_number: delta -0.0587 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on SLC35G1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SLC35G1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4780,TP53,NFE2L2,ENTREZ:5116,PCNT,within_lineage,Esophagus/Stomach,precision_eligible,False,-0.2241374144392805,-0.3079512272324823,-0.1403236016460787,0.04249230689404348,0.70840108135314,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Sema4D in semaphorin signaling (FDR=0.0395); GSEA: Signaling by VEGF (FDR=0.0395); GSEA: Phase I - Functionalization of compounds (FDR=0.0395),expression: delta -0.307 (unadjusted contrast; not causal); copy_number: delta -0.0692 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NFE2L2 is associated with stronger CRISPR dependency on PCNT; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PCNT with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:288,APC,ANK3,ENTREZ:731220,RFX8,within_lineage,Bowel,precision_eligible,False,-0.2521311094681161,-0.3435115593619801,-0.1607506595742522,0.042499646173292625,0.7085234365213217,0.0003177466147393907,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.174 (unadjusted contrast; not causal); copy_number: delta -0.0632 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ANK3 is associated with stronger CRISPR dependency on RFX8; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb RFX8 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:23345,APC,SYNE1,ENTREZ:84331,MCRIP2,within_lineage,Bowel,precision_eligible,False,-0.2675579602096514,-0.3646195439092193,-0.1704963765100834,0.042797335987942726,0.7134863063210668,0.03831634911764394,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.698 (unadjusted contrast; not causal); copy_number: delta -0.0377 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on MCRIP2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MCRIP2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:27445,TP53,PCLO,ENTREZ:57106,NAT14,within_lineage,Lung,precision_eligible,False,-0.1492874203486451,-0.2079368926330635,-0.0906379480642267,0.042797335987942726,0.7134863063210668,0.023576165448393346,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.354 (unadjusted contrast; not causal); copy_number: delta 0.113 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PCLO is associated with stronger CRISPR dependency on NAT14; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NAT14 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:23345,TP53,SYNE1,ENTREZ:55319,TMA16,within_lineage,Lung,precision_eligible,False,-0.186587078008055,-0.2599440121596447,-0.1132301438564653,0.04311023214630326,0.7187026853114227,0.0022582247839471313,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (FDR=0.0496); GSEA: mRNA Splicing - Minor Pathway (FDR=0.0496); GSEA: Transport of the SLBP Dependant Mature mRNA (FDR=0.0496),expression: delta -0.233 (unadjusted contrast; not causal); copy_number: delta -0.018 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on TMA16; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TMA16 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:7015,TP53,TERT,ENTREZ:722,C4BPA,within_lineage,Lung,precision_eligible,False,-0.0669716201560363,-0.0933336494830283,-0.0406095908290443,0.04384061822722524,0.730879155062067,3.5132444408333763e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.643 (unadjusted contrast; not causal); copy_number: delta -0.0696 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in TERT is associated with stronger CRISPR dependency on C4BPA; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C4BPA with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:79631,EFL1,within_lineage,Bowel,precision_eligible,False,-1.7586703767213585,-2.104756177417693,-1.412584576025023,0.04396001654842635,0.7328696777244756,0.001040615355027238,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.216 (unadjusted contrast; not causal); copy_number: delta 0.0535 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on EFL1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb EFL1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:7273,BRAF,TTN,ENTREZ:23500,DAAM2,within_lineage,Bowel,precision_eligible,False,-0.4307808097788753,-0.5155755094668928,-0.3459861100908579,0.04396001654842635,0.7328696777244756,0.001040615355027238,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.403 (unadjusted contrast; not causal); copy_number: delta -0.0267 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on DAAM2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DAAM2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:10664,ENTREZ:288,CTCF,ANK3,ENTREZ:152206,CCDC13,within_lineage,Uterus,precision_eligible,False,-0.3946703628329831,-0.480521042887279,-0.3088196827786872,0.04396001654842635,0.7328696777244756,0.03957788697211413,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.158 (unadjusted contrast; not causal); copy_number: delta -0.136 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in CTCF, the presence of an annotated variant in ANK3 is associated with stronger CRISPR dependency on CCDC13; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CCDC13 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:7468,APC,NSD2,ENTREZ:401666,OR51A4,within_lineage,Bowel,precision_eligible,False,-0.2043373893562695,-0.2750985389747423,-0.1335762397377967,0.04396001654842635,0.7328696777244756,0.00047963876861091244,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0 (unadjusted contrast; not causal); copy_number: delta -0.0747 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in NSD2 is associated with stronger CRISPR dependency on OR51A4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR51A4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:7403,TTN,KDM6A,ENTREZ:23515,MORC3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2397236494600587,-0.3171308006142928,-0.1623164983058246,0.04127624842495837,0.7395756895555524,0.0206885720925328,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.16 (unadjusted contrast; not causal); copy_number: delta -0.05 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in KDM6A is associated with stronger CRISPR dependency on MORC3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MORC3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:673,ENTREZ:472,BRAF,ATM,ENTREZ:285755,PPIL6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1471002486525351,-0.1989528186834612,-0.0952476786216091,0.0419451914782475,0.7515616146041709,0.01903738331268079,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.178 (unadjusted contrast; not causal); copy_number: delta 0.0125 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in BRAF, the presence of an annotated variant in ATM is associated with stronger CRISPR dependency on PPIL6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PPIL6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2033,TP53,EP300,ENTREZ:4646,MYO6,within_lineage,Bowel,precision_eligible,False,-0.2225125812246075,-0.3036825425199372,-0.1413426199292778,0.04545015477883385,0.7577121871325563,0.000638525338224253,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.278 (unadjusted contrast; not causal); copy_number: delta 0.131 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EP300 is associated with stronger CRISPR dependency on MYO6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MYO6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ENTREZ:8340,H2BC13,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.6439842608365199,-0.8556148893270843,-0.4323536323459556,0.042556414008759307,0.7625133202878159,6.664590789067346e-11,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.571 (unadjusted contrast; not causal); copy_number: delta 0.053 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in ASXL2 is associated with stronger CRISPR dependency on H2BC13; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb H2BC13 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ENTREZ:256957,HEATR9,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1337808242616595,-0.1842148424502479,-0.083346806073071,0.042556414008759307,0.7625133202878159,8.85093841555611e-05,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00184 (unadjusted contrast; not causal); copy_number: delta -0.0336 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in JAK2 is associated with stronger CRISPR dependency on HEATR9; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HEATR9 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:646658,SYNDIG1L,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1036217875161453,-0.1432390380296198,-0.0640045370026708,0.042556414008759307,0.7625133202878159,2.5311773649289936e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0191 (unadjusted contrast; not causal); copy_number: delta -0.0168 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NBN is associated with stronger CRISPR dependency on SYNDIG1L; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SYNDIG1L with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7273,ENTREZ:1788,TTN,DNMT3A,ENTREZ:9179,AP4M1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.153112196042385,-0.2060539809176545,-0.1001704111671155,0.04278791020039555,0.7666612010204878,4.6964441538316514e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.311 (unadjusted contrast; not causal); copy_number: delta 0.0519 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TTN, the presence of an annotated variant in DNMT3A is associated with stronger CRISPR dependency on AP4M1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb AP4M1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:94027,CGB7,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1286230069005697,-0.1770620823634912,-0.0801839314376482,0.04286555988060074,0.7680525051717343,1.0987765920010625e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.00956 (unadjusted contrast; not causal); copy_number: delta -0.0484 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on CGB7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CGB7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:29072,TP53,SETD2,ENTREZ:11132,CAPN10,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0726784352795151,-0.1001348294259787,-0.0452220411330515,0.0430867913183646,0.7720164650609919,0.0001948870953143044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.223 (unadjusted contrast; not causal); copy_number: delta 0.0985 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in SETD2 is associated with stronger CRISPR dependency on CAPN10; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CAPN10 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5728,TP53,PTEN,ENTREZ:54827,NXPE4,within_lineage,Lung,precision_eligible,False,-0.0919248822481792,-0.128258000592051,-0.0555917639043075,0.04642008702353904,0.7738821976876845,0.006748505338180818,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0119 (unadjusted contrast; not causal); copy_number: delta -0.0457 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PTEN is associated with stronger CRISPR dependency on NXPE4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NXPE4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ENTREZ:10490,VTI1B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3565889574728886,-0.4781302028422647,-0.2350477121035125,0.043506995391151736,0.7795455581531268,0.004468750801494793,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0319 (unadjusted contrast; not causal); copy_number: delta -0.017 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on VTI1B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb VTI1B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:2257,FGF12,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0811112136700347,-0.1119720876432942,-0.0502503396967752,0.043506995391151736,0.7795455581531268,1.0987765920010625e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.358 (unadjusted contrast; not causal); copy_number: delta -0.108 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on FGF12; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FGF12 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:10780,ZNF234,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.06827685351113,-0.0943495424164747,-0.0422041646057852,0.043506995391151736,0.7795455581531268,4.502263395179459e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.542 (unadjusted contrast; not causal); copy_number: delta 0.0661 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PREX2 is associated with stronger CRISPR dependency on ZNF234; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF234 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:672,TP53,BRCA1,ENTREZ:8843,HCAR3,within_lineage,Breast,precision_eligible,False,-0.2111101267735683,-0.2856571283515317,-0.1365631251956051,0.04692805466200715,0.7823506676457995,0.0007728967039296098,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: RNA Polymerase I Transcription (FDR=0.043); GSEA: Polymerase switching on the C-strand of the telomere (FDR=0.043); GSEA: Processing of SMDT1 (FDR=0.043),expression: delta -0.129 (unadjusted contrast; not causal); copy_number: delta -0.192 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRCA1 is associated with stronger CRISPR dependency on HCAR3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HCAR3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:284434,TP53,NWD1,ENTREZ:25839,COG4,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2855458551181669,-0.395000342869463,-0.1760913673668708,0.04401913575463513,0.7887219386849252,0.006172245171030115,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.128 (unadjusted contrast; not causal); copy_number: delta -0.0584 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in NWD1 is associated with stronger CRISPR dependency on COG4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb COG4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:29943,PADI1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1462146421448982,-0.2019436310046661,-0.0904856532851303,0.044099223657485045,0.7901569301930069,1.0987765920010625e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0831 (unadjusted contrast; not causal); copy_number: delta 0.15 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRIP1 is associated with stronger CRISPR dependency on PADI1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb PADI1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:51466,EVL,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1438423191968457,-0.198861959010748,-0.0888226793829434,0.044167899519995384,0.7913874441159048,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.653 (unadjusted contrast; not causal); copy_number: delta 0.031 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on EVL; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb EVL with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:54888,NSUN2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1509569917311331,-0.2090808230434838,-0.0928331604187825,0.04436982044544949,0.7950054039203166,0.00034784794103089956,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.429 (unadjusted contrast; not causal); copy_number: delta 0.0576 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RHOA is associated with stronger CRISPR dependency on NSUN2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NSUN2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ENTREZ:1551,CYP3A7,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2305253308940723,-0.314551439873723,-0.1464992219144215,0.04485307286228689,0.8036641787133232,0.001230725375041839,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.051 (unadjusted contrast; not causal); copy_number: delta -0.136 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KCNA4 is associated with stronger CRISPR dependency on CYP3A7; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb CYP3A7 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:8289,TP53,ARID1A,ENTREZ:6300,MAPK12,within_lineage,Lung,precision_eligible,False,-0.1247054389665394,-0.1741382807079024,-0.0752725972251764,0.048299582960034934,0.8052157978410611,0.01796889823527527,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.176 (unadjusted contrast; not causal); copy_number: delta 0.0352 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ARID1A is associated with stronger CRISPR dependency on MAPK12; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb MAPK12 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:341640,TP53,FREM2,ENTREZ:197370,NSMCE1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.3200501156241513,-0.4422032665053015,-0.197896964743001,0.04494723397076916,0.8053513297842764,0.008119808572620044,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.103 (unadjusted contrast; not causal); copy_number: delta -0.0418 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FREM2 is associated with stronger CRISPR dependency on NSMCE1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NSMCE1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ENTREZ:84838,ZNF496,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1409614576574697,-0.1894151924394395,-0.0925077228754998,0.04500681417797754,0.8064188704283857,0.0029346879448226724,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.155 (unadjusted contrast; not causal); copy_number: delta 0.0196 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in CDKN2A, the presence of an annotated variant in MUC16 is associated with stronger CRISPR dependency on ZNF496; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZNF496 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:100190949,C5orf52,within_lineage,Lung,precision_eligible,False,-0.1298713049453076,-0.1813930205522532,-0.0783495893383621,0.04858610654218138,0.8099925122692008,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00354 (unadjusted contrast; not causal); copy_number: delta -0.141 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on C5orf52; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C5orf52 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:115572,TENT5B,within_lineage,Lung,precision_eligible,False,-0.1288409202176021,-0.1799714099311417,-0.0777104305040626,0.048751839213853676,0.8127554877913573,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.309 (unadjusted contrast; not causal); copy_number: delta 0.0355 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on TENT5B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TENT5B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:672,TP53,BRCA1,ENTREZ:79075,DSCC1,within_lineage,Breast,precision_eligible,False,-0.4228096819536366,-0.5729787768266377,-0.2726405870806355,0.0493889488766738,0.823376920400505,0.0007728967039296098,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,GSEA: RNA Polymerase I Transcription (FDR=0.043); GSEA: Polymerase switching on the C-strand of the telomere (FDR=0.043); GSEA: Processing of SMDT1 (FDR=0.043),expression: delta 0.7 (unadjusted contrast; not causal); copy_number: delta -0.0406 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in BRCA1 is associated with stronger CRISPR dependency on DSCC1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb DSCC1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:324,ENTREZ:23345,APC,SYNE1,ENTREZ:9618,TRAF4,within_lineage,Bowel,precision_eligible,False,-0.22907056318509,-0.3133199660428492,-0.1448211603273308,0.0493889488766738,0.823376920400505,0.03831634911764394,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.179 (unadjusted contrast; not causal); copy_number: delta -0.0283 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in APC, the presence of an annotated variant in SYNE1 is associated with stronger CRISPR dependency on TRAF4; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TRAF4 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ENTREZ:343171,OR2W3,within_lineage,Head and Neck,precision_eligible,False,-0.0775319012163392,-0.1061524542537217,-0.0489113481789566,0.0493889488766738,0.823376920400505,0.006938299567639482,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.222 (unadjusted contrast; not causal); copy_number: delta -0.228 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in PIK3CA is associated with stronger CRISPR dependency on OR2W3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR2W3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2195,TP53,FAT1,ENTREZ:85302,FBF1,within_lineage,Lung,precision_eligible,False,-0.1339501409953649,-0.1872134178412189,-0.0806868641495108,0.04964583893703895,0.8276596061347798,2.281580096041547e-09,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.325 (unadjusted contrast; not causal); copy_number: delta -0.0825 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT1 is associated with stronger CRISPR dependency on FBF1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb FBF1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:4703,ENTREZ:7273,NEB,TTN,ENTREZ:79918,SETD6,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1298366134657015,-0.1621505806378118,-0.0975226462935913,0.04620971094457423,0.8279720212007304,0.027388103610856564,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.465 (unadjusted contrast; not causal); copy_number: delta 0.0637 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in NEB, the presence of an annotated variant in TTN is associated with stronger CRISPR dependency on SETD6; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SETD6 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2196,TP53,FAT2,ENTREZ:79829,NAA40,within_lineage,Lung,precision_eligible,False,-0.1647324713370345,-0.230249872428471,-0.0992150702455979,0.049744492761553676,0.8293042915160682,0.0023006227792988637,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.197 (unadjusted contrast; not causal); copy_number: delta 0.0507 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in FAT2 is associated with stronger CRISPR dependency on NAA40; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb NAA40 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9817,TP53,KEAP1,ENTREZ:51341,ZBTB7A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1943241696618382,-0.268458712947268,-0.1201896263764084,0.04661634764849907,0.8352580181645913,5.265940490010591e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.0328 (unadjusted contrast; not causal); copy_number: delta -0.0601 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in KEAP1 is associated with stronger CRISPR dependency on ZBTB7A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ZBTB7A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:23034,SAMD4A,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1256835692495913,-0.1739545111939596,-0.0774126273052229,0.04661634764849907,0.8352580181645913,2.587704264232238e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.359 (unadjusted contrast; not causal); copy_number: delta -0.0556 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNB1 is associated with stronger CRISPR dependency on SAMD4A; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb SAMD4A with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ENTREZ:390260,OR6X1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1291932506494017,-0.1746369982777403,-0.083749503021063,0.04738610922498363,0.8490503798845995,0.0005460658986232966,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.00103 (unadjusted contrast; not causal); copy_number: delta -0.0135 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in MAP2K4 is associated with stronger CRISPR dependency on OR6X1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb OR6X1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:171019,ADAMTS19,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.0828066135741398,-0.1146523526189916,-0.050960874529288,0.04778316459225215,0.8561647012738898,2.0614001215747637e-06,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.187 (unadjusted contrast; not causal); copy_number: delta -0.0377 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in ASTN1 is associated with stronger CRISPR dependency on ADAMTS19; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ADAMTS19 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ENTREZ:50809,HP1BP3,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.175656928708333,-0.2434097388408002,-0.1079041185758658,0.047859364099304774,0.8575300216487465,0.0001041167154611385,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0688 (unadjusted contrast; not causal); copy_number: delta -0.0228 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CTNNA2 is associated with stronger CRISPR dependency on HP1BP3; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HP1BP3 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:9699,TP53,RIMS2,ENTREZ:388585,HES5,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1314810959047832,-0.1826603815451608,-0.0803018102644055,0.04817919490296867,0.8632606560011117,0.04511713822927242,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.0331 (unadjusted contrast; not causal); copy_number: delta -0.0661 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RIMS2 is associated with stronger CRISPR dependency on HES5; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb HES5 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:7027,TFDP1,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.2963636460733194,-0.4126767565317689,-0.1800505356148698,0.049563955481862716,0.8880723891184472,2.6913039776546925e-08,computational_hypothesis_with_context_annotations,unavailable,internally_replicated,False,GSEA: RHO GTPases Activate WASPs and WAVEs (FDR=0.0317); GSEA: APC truncation mutants have impaired AXIN binding (FDR=0.0317); GSEA: APC/C-mediated degradation of cell cycle proteins (FDR=0.0317),expression: delta 0.788 (unadjusted contrast; not causal); copy_number: delta 0.169 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in RB1 is associated with stronger CRISPR dependency on TFDP1; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb TFDP1 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ENTREZ:136,ADORA2B,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1285905563914187,-0.1767980276808167,-0.0803830851020206,0.04964463920664135,0.8895180563887555,0.0003541895182373382,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.43 (unadjusted contrast; not causal); copy_number: delta 0.473 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in CDH1 is associated with stronger CRISPR dependency on ADORA2B; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb ADORA2B with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7015,ENTREZ:196528,TERT,ARID2,ENTREZ:388272,C16orf87,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1440154596614626,-0.1979986650861039,-0.0900322542368212,0.04969838848371989,0.8904811201403158,0.0005548747937621566,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta -0.292 (unadjusted contrast; not causal); copy_number: delta -0.153 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TERT, the presence of an annotated variant in ARID2 is associated with stronger CRISPR dependency on C16orf87; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb C16orf87 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:22864,R3HDM2,pan_cancer_conditional,PAN_CANCER,precision_eligible,True,-0.1311201555375655,-0.1815357170342917,-0.0807045940408393,0.04969838848371989,0.8904811201403158,9.322218911980652e-07,computational_hypothesis_with_context_annotations,unavailable,holdout_underpowered,False,not established,expression: delta 0.324 (unadjusted contrast; not causal); copy_number: delta 0.0117 (unadjusted contrast; not causal),"In cancer models bearing an annotated damaging/hotspot variant in TP53, the presence of an annotated variant in EPHA7 is associated with stronger CRISPR dependency on R3HDM2; possible pathway involvement requires direct perturbation tests.",Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association,"Use lineage-matched, preferably isogenic models in all four A/B genotype states; perturb R3HDM2 with at least two independent guides plus rescue; quantify growth/viability, predefine contrasts and A×B interaction, and repeat across independently generated models.",required_before_manuscript_claim diff --git a/results/Main_C1_C2/internal_holdout_confirmation.csv b/results/Main_C1_C2/internal_holdout_confirmation.csv new file mode 100644 index 0000000000000000000000000000000000000000..6c859fbbb3ae37be5efa704405e95285f3818ebf --- /dev/null +++ b/results/Main_C1_C2/internal_holdout_confirmation.csv @@ -0,0 +1,547 @@ +A,B,Scope,Lineage,gene,status,direction_matches,n00,n01,n10,n11,reason,holdout_beta,holdout_p,holdout_ci_low,holdout_ci_high,holdout_se_hc3,holdout_q_selected_family,not_independent_experimental_validation,holdout_q_within_context_legacy,confirmation_family +ENTREZ:1029,ENTREZ:2195,pan_cancer_conditional,PAN_CANCER,ENTREZ:91754,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:1029,ENTREZ:7179,pan_cancer_conditional,PAN_CANCER,ENTREZ:6665,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:1029,ENTREZ:94025,pan_cancer_conditional,PAN_CANCER,ENTREZ:91612,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:1029,ENTREZ:94025,pan_cancer_conditional,PAN_CANCER,ENTREZ:84838,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:10664,ENTREZ:27445,pan_cancer_conditional,PAN_CANCER,ENTREZ:7737,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:10664,ENTREZ:27445,within_lineage,Uterus,ENTREZ:7737,holdout_underpowered,,0,0,2,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:10664,ENTREZ:288,within_lineage,Uterus,ENTREZ:152206,holdout_underpowered,,0,0,2,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:23224,ENTREZ:10664,pan_cancer_conditional,PAN_CANCER,ENTREZ:348013,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:2956,ENTREZ:27445,pan_cancer_conditional,PAN_CANCER,ENTREZ:64768,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:2956,ENTREZ:288,pan_cancer_conditional,PAN_CANCER,ENTREZ:3356,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:10664,pan_cancer_conditional,PAN_CANCER,ENTREZ:162333,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:10664,pan_cancer_conditional,PAN_CANCER,ENTREZ:644591,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:196528,within_lineage,Bowel,ENTREZ:6648,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:1850,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:440021,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:151011,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:10845,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:84331,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:346288,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:9618,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:288,within_lineage,Bowel,ENTREZ:731220,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:288,within_lineage,Bowel,ENTREZ:7314,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:2956,pan_cancer_conditional,PAN_CANCER,ENTREZ:80167,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:2956,within_lineage,Bowel,ENTREZ:80167,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:2956,within_lineage,Bowel,ENTREZ:57535,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:341640,within_lineage,Bowel,ENTREZ:23435,holdout_underpowered,,0,0,9,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:4144,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:23787,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:50833,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:55252,pan_cancer_conditional,PAN_CANCER,ENTREZ:414062,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:55252,pan_cancer_conditional,PAN_CANCER,ENTREZ:8340,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:55252,pan_cancer_conditional,PAN_CANCER,ENTREZ:341276,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:55252,pan_cancer_conditional,PAN_CANCER,ENTREZ:64777,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:57683,within_lineage,Bowel,ENTREZ:23397,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:57683,within_lineage,Bowel,ENTREZ:6635,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:1175,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:55726,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:81832,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1173,holdout_underpowered,,0,0,1,9,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1175,holdout_underpowered,,0,0,1,9,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:55726,holdout_underpowered,,0,0,1,9,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:81832,holdout_underpowered,,0,0,1,9,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7273,within_lineage,Bowel,ENTREZ:390326,holdout_model_not_estimable,,0,0,5,5,Insufficient residual degrees of freedom,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7468,pan_cancer_conditional,PAN_CANCER,ENTREZ:26595,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7468,within_lineage,Bowel,ENTREZ:401666,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:7468,within_lineage,Bowel,ENTREZ:26595,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:79633,within_lineage,Bowel,ENTREZ:151011,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:79776,pan_cancer_conditional,PAN_CANCER,ENTREZ:387748,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:80816,within_lineage,Bowel,ENTREZ:284119,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:8085,within_lineage,Bowel,ENTREZ:81930,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:8085,within_lineage,Bowel,ENTREZ:5204,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:8289,within_lineage,Bowel,ENTREZ:10276,holdout_underpowered,,0,0,10,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:84159,pan_cancer_conditional,PAN_CANCER,ENTREZ:116238,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9585,pan_cancer_conditional,PAN_CANCER,ENTREZ:7071,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9585,pan_cancer_conditional,PAN_CANCER,ENTREZ:8390,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9585,pan_cancer_conditional,PAN_CANCER,ENTREZ:25989,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9699,pan_cancer_conditional,PAN_CANCER,ENTREZ:64506,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9699,pan_cancer_conditional,PAN_CANCER,ENTREZ:81472,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9699,pan_cancer_conditional,PAN_CANCER,ENTREZ:10490,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:64506,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:29926,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:81472,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:10490,holdout_underpowered,,0,0,8,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,pan_cancer_conditional,PAN_CANCER,ENTREZ:79863,holdout_underpowered,,0,0,6,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,pan_cancer_conditional,PAN_CANCER,ENTREZ:6617,holdout_underpowered,,0,0,6,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,pan_cancer_conditional,PAN_CANCER,ENTREZ:6375,holdout_underpowered,,0,0,6,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:10317,holdout_underpowered,,0,0,5,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:26735,holdout_underpowered,,0,0,5,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:338755,holdout_underpowered,,0,0,5,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:8771,holdout_underpowered,,0,0,5,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:123016,holdout_underpowered,,0,0,5,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2196,within_lineage,Bowel,ENTREZ:79934,holdout_underpowered,,0,0,4,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2196,within_lineage,Bowel,ENTREZ:84441,holdout_underpowered,,0,0,4,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:10845,holdout_underpowered,,0,0,6,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:84331,holdout_underpowered,,0,0,6,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:55291,holdout_underpowered,,0,0,6,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2956,within_lineage,Bowel,ENTREZ:64746,holdout_underpowered,,0,0,5,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:2956,within_lineage,Bowel,ENTREZ:339230,holdout_underpowered,,0,0,5,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:54894,pan_cancer_conditional,PAN_CANCER,ENTREZ:56658,holdout_underpowered,,0,0,4,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1718,holdout_underpowered,,0,0,1,5,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7157,within_lineage,Bowel,ENTREZ:57646,holdout_underpowered,,0,0,1,5,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7157,within_lineage,Pancreas,ENTREZ:1106,holdout_underpowered,,0,0,2,6,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:84871,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10380,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:91409,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:26235,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10841,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10046,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4354,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4544,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:5173,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:6166,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:6519,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:136895,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:159195,holdout_underpowered,,0,0,3,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:3845,ENTREZ:94025,within_lineage,Bowel,ENTREZ:81168,holdout_underpowered,,0,0,6,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:4703,ENTREZ:1387,within_lineage,Bowel,ENTREZ:647174,holdout_underpowered,,0,0,1,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:4703,ENTREZ:7273,pan_cancer_conditional,PAN_CANCER,ENTREZ:79918,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:64922,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:8605,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:83852,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5290,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7157,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5290,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10082,holdout_underpowered,,0,0,0,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5290,ENTREZ:7273,within_lineage,Bowel,ENTREZ:90529,holdout_underpowered,,0,0,0,3,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5290,ENTREZ:7273,within_lineage,Uterus,ENTREZ:5338,holdout_underpowered,,0,0,2,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:55294,ENTREZ:1387,pan_cancer_conditional,PAN_CANCER,ENTREZ:140688,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:55294,ENTREZ:1387,within_lineage,Bowel,ENTREZ:140688,holdout_underpowered,,0,0,2,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:55294,ENTREZ:7273,within_lineage,Bowel,ENTREZ:9455,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:9575,holdout_underpowered,,0,0,2,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:22944,holdout_underpowered,,0,0,2,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:144195,holdout_underpowered,,0,0,2,1,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5728,ENTREZ:19,within_lineage,Uterus,ENTREZ:5592,holdout_underpowered,,0,0,4,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:5728,ENTREZ:22986,pan_cancer_conditional,PAN_CANCER,ENTREZ:84765,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:1215,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:285755,holdout_underpowered,,0,0,0,0,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7157,holdout_underpowered,,0,0,10,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7157,within_lineage,Skin,ENTREZ:11200,holdout_underpowered,,0,0,10,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7157,within_lineage,Skin,ENTREZ:7157,holdout_underpowered,,0,0,10,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:567,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:23500,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:55096,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:79631,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:23219,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:2739,holdout_underpowered,,0,0,1,2,,,,,,,1.0,True,,all_nominated_findings_including_untestable_p1 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+crispr,CRISPRGeneEffect.csv,51064667,6edf7ade09b9b34199210b559d4745d3,6edf7ade09b9b34199210b559d4745d3,True,True,VERIFIED +damaging,OmicsSomaticMutationsMatrixDamaging.csv,51065747,cb20fdbe1cf3b9b0d8ed4f53e1f399b6,cb20fdbe1cf3b9b0d8ed4f53e1f399b6,True,True,VERIFIED +hotspot,OmicsSomaticMutationsMatrixHotspot.csv,51065750,a5aeb1deef897ead3c955c372148d840,a5aeb1deef897ead3c955c372148d840,True,True,VERIFIED +expression,OmicsExpressionProteinCodingGenesTPMLogp1.csv,51065489,71794802b750ce77c422dad0720a40af,71794802b750ce77c422dad0720a40af,True,True,VERIFIED +copy_number,OmicsCNGene.csv,51065324,4696565fa74dc805983bc278b4a41802,4696565fa74dc805983bc278b4a41802,True,True,VERIFIED +common_essential,CRISPRInferredCommonEssentials.csv,51064916,545edef0d377f252db6e5e675201bd77,545edef0d377f252db6e5e675201bd77,True,True,VERIFIED diff --git a/results/Main_C1_C2/qc/C2_Methods.csv b/results/Main_C1_C2/qc/C2_Methods.csv new file mode 100644 index 0000000000000000000000000000000000000000..756532d3498db459d91aaca074b16316ee6eb6e9 --- /dev/null +++ b/results/Main_C1_C2/qc/C2_Methods.csv @@ -0,0 +1,2 @@ +rule,deletion,not_independent_replication +Original: dependence_robust_signal AND precision_eligible AND finite effect/CI,"leave-one-model + leave-one-lineage, same original fitted cohort",True diff --git a/results/Main_C1_C2/qc/C3_Exploratory_Null_And_Estimability.json b/results/Main_C1_C2/qc/C3_Exploratory_Null_And_Estimability.json new file mode 100644 index 0000000000000000000000000000000000000000..65428118d82d859987705775067aa4f4d79e80e2 --- /dev/null +++ b/results/Main_C1_C2/qc/C3_Exploratory_Null_And_Estimability.json @@ -0,0 +1,7 @@ +{ + "C3_attempted_contexts": 2056, + "C3_gene_test_contexts": 280, + "C3_significant_gene_tests": 0, + "n_less_sample_four_group": 1776, + "no_interaction_significance_is_not_equivalence": true +} \ No newline at end of file diff --git a/results/Main_C1_C2/qc/External_C5_Validation_Limitation.json b/results/Main_C1_C2/qc/External_C5_Validation_Limitation.json new file mode 100644 index 0000000000000000000000000000000000000000..3302d045882b9f984dbee17eb24bb1a684eaf840 --- /dev/null +++ b/results/Main_C1_C2/qc/External_C5_Validation_Limitation.json @@ -0,0 +1,7 @@ +{ + "inference": "Internal holdout is not a new biological cohort; no external C5 validation is inferred", + "main_result_dependency": "NONE", + "no_fabricated_zero_testable_claim": true, + "stage": "direct_C5_external_CRISPR_replication", + "status": "NOT_CLAIMED_NO_VERIFIABLE_GENOTYPED_NONOVERLAPPING_COHORT" +} \ No newline at end of file diff --git a/results/Main_C1_C2/qc/actual_workload.json b/results/Main_C1_C2/qc/actual_workload.json new file mode 100644 index 0000000000000000000000000000000000000000..f67b19860abd055a7fd52ca317dd132a919aeb77 --- /dev/null +++ b/results/Main_C1_C2/qc/actual_workload.json @@ -0,0 +1,7 @@ +{ + "all_ordered_pairs": 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+ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:83858,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:7555,EXECUTED,,-0.3940936007462385,61.0,59.0,2.0,1.0,0.020962565069010453,-0.41505616581524896,-0.3756679419166131 +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:2237,EXECUTED,,-0.4536906371662968,61.0,59.0,2.0,1.0,0.02167924702777413,-0.47503707739920253,-0.4320113901385227 +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:8348,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:54626,EXECUTED,,-0.16691113201601773,61.0,59.0,2.0,1.0,0.00878755402641776,-0.1756986860424355,-0.1608618380715495 +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:10553,EXECUTED,,-0.2353982587849002,61.0,59.0,2.0,1.0,0.022445393374356915,-0.25323486322343436,-0.21295286541054328 +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:10186,EXECUTED,,-0.2818135194007482,61.0,59.0,2.0,1.0,0.019599584656973756,-0.301413104057722,-0.2673113378834093 +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:54629,EXECUTED,,-0.2287829896913837,61.0,59.0,2.0,1.0,0.016862035372719963,-0.24197147496715563,-0.21192095431866373 +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:5479,EXECUTED,,-0.24000786295650786,61.0,59.0,2.0,1.0,0.016798088303909026,-0.2534162843602702,-0.22320977465259884 +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:7942,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:7416,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:472,pan_cancer_conditional,PAN_CANCER,ENTREZ:220992,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:4893,pan_cancer_conditional,PAN_CANCER,ENTREZ:4893,EXECUTED,,-1.4337848368484096,91.0,90.0,1.0,1.0,0.14532420848473704,-1.5255177242726738,-1.2884606283636726 +ENTREZ:7015,ENTREZ:4893,pan_cancer_conditional,PAN_CANCER,ENTREZ:9989,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:4893,pan_cancer_conditional,PAN_CANCER,ENTREZ:8036,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:53353,pan_cancer_conditional,PAN_CANCER,ENTREZ:90557,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:53353,pan_cancer_conditional,PAN_CANCER,ENTREZ:148738,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:53353,pan_cancer_conditional,PAN_CANCER,ENTREZ:140807,EXECUTED,,-0.12211901906204102,106.0,103.0,3.0,1.0,0.006735584878838505,-0.12783940639897076,-0.11538343418320252 +ENTREZ:7015,ENTREZ:53353,pan_cancer_conditional,PAN_CANCER,ENTREZ:90678,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:673,pan_cancer_conditional,PAN_CANCER,ENTREZ:673,EXECUTED,,-1.091094618722888,91.0,91.0,0.0,1.0,0.09429276739713477,-1.1521922505133013,-0.9968018513257533 +ENTREZ:7015,ENTREZ:673,pan_cancer_conditional,PAN_CANCER,ENTREZ:5604,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:472,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:1026,EXECUTED,,-0.3248516515795883,156.0,156.0,0.0,1.0,0.04134405407675301,-0.349271973516872,-0.2835075975028353 +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:11200,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7157,EXECUTED,,-0.6690480767468654,156.0,156.0,0.0,1.0,0.05772203168187051,-0.6969521665912694,-0.6113260450649949 +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7158,EXECUTED,,-0.26736802497011203,156.0,156.0,0.0,1.0,0.02195664931254604,-0.28932467428265807,-0.2482290727932757 +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:3093,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:57646,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:80731,pan_cancer_conditional,PAN_CANCER,ENTREZ:10494,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10051,pan_cancer_conditional,PAN_CANCER,ENTREZ:55847,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10051,pan_cancer_conditional,PAN_CANCER,ENTREZ:2512,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1009,pan_cancer_conditional,PAN_CANCER,ENTREZ:440023,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:9311,EXECUTED,,-0.09157142289896415,108.0,101.0,7.0,1.0,0.005954241405183108,-0.0962215279464787,-0.08561718149378104 +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:143384,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:1843,EXECUTED,,-0.16443117174590738,108.0,101.0,7.0,1.0,0.008423184661179917,-0.16932017985836392,-0.15600798708472746 +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:654346,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:54555,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:55004,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:79142,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:4659,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:144535,pan_cancer_conditional,PAN_CANCER,ENTREZ:392309,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:144535,pan_cancer_conditional,PAN_CANCER,ENTREZ:57139,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:50809,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:79944,EXECUTED,,-0.1757264475669164,148.0,145.0,3.0,1.0,0.017811099684393483,-0.18376516754157413,-0.15791534788252293 +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:4499,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:8387,EXECUTED,,-0.16543199722699212,148.0,145.0,3.0,1.0,0.00899003731748485,-0.17361277973199646,-0.15644195990950727 +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:55111,EXECUTED,,-0.0988522423899898,148.0,145.0,3.0,1.0,0.0068096935411101345,-0.10566193593109993,-0.09355761853204639 +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:6434,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:23097,EXECUTED,,-0.0833633961359934,137.0,130.0,7.0,1.0,0.00301957195038359,-0.086382968086377,-0.08056795897189067 +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:51084,EXECUTED,,-0.13526758646192602,137.0,130.0,7.0,1.0,0.007332991839494457,-0.1419575899274239,-0.12793459462243156 +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:22826,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:23196,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:79066,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:9883,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:23034,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:57606,EXECUTED,,-0.1082138559686604,137.0,130.0,7.0,1.0,0.005928733149632728,-0.11414258911829313,-0.10559288987697676 +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:6510,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:6667,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:54662,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:158358,pan_cancer_conditional,PAN_CANCER,ENTREZ:114799,EXECUTED,,-0.31685548567263705,61.0,54.0,7.0,1.0,0.017518001294283603,-0.3255429590229539,-0.29933748437835345 +ENTREZ:7157,ENTREZ:158358,pan_cancer_conditional,PAN_CANCER,ENTREZ:403239,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:158358,pan_cancer_conditional,PAN_CANCER,ENTREZ:114836,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:25841,EXECUTED,,-0.1567665833091063,127.0,120.0,7.0,1.0,0.005293541266556068,-0.16206012457566238,-0.1516388234254819 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:1719,EXECUTED,,-0.5396753485849626,127.0,120.0,7.0,1.0,0.01518735642875968,-0.5548627050137223,-0.5290207263869724 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:1876,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:203111,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:3346,EXECUTED,,-0.12598866018833998,127.0,120.0,7.0,1.0,0.004334458472692579,-0.13026213438020592,-0.1216542017156474 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:83901,EXECUTED,,-0.10761276814103016,127.0,120.0,7.0,1.0,0.005168873173904354,-0.11169821745965237,-0.1024438949671258 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:283092,EXECUTED,,-0.12307027684832164,127.0,120.0,7.0,1.0,0.007468830002295063,-0.1305391068506167,-0.1190048074412233 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:440560,EXECUTED,,-0.20678433193985,127.0,120.0,7.0,1.0,0.008233870906340562,-0.2106551876760227,-0.19855046103350943 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:22864,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:11037,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:100287238,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:7552,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:219285,pan_cancer_conditional,PAN_CANCER,ENTREZ:3052,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:219285,pan_cancer_conditional,PAN_CANCER,ENTREZ:79295,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26046,pan_cancer_conditional,PAN_CANCER,ENTREZ:81027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26047,pan_cancer_conditional,PAN_CANCER,ENTREZ:84320,EXECUTED,,-0.12107713841244085,108.0,101.0,7.0,1.0,0.003614442195070122,-0.12469158060751097,-0.11781668063976831 +ENTREZ:7157,ENTREZ:26047,pan_cancer_conditional,PAN_CANCER,ENTREZ:222389,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26047,pan_cancer_conditional,PAN_CANCER,ENTREZ:27319,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2625,pan_cancer_conditional,PAN_CANCER,ENTREZ:57670,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2625,pan_cancer_conditional,PAN_CANCER,ENTREZ:63933,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:284434,pan_cancer_conditional,PAN_CANCER,ENTREZ:25839,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:284434,pan_cancer_conditional,PAN_CANCER,ENTREZ:81168,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:11132,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:833,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:84248,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:9856,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:64324,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:10267,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:54439,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,pan_cancer_conditional,PAN_CANCER,ENTREZ:197370,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,pan_cancer_conditional,PAN_CANCER,ENTREZ:23435,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:1116,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:4744,EXECUTED,,-0.18110655386307375,127.0,120.0,7.0,1.0,0.012256084787739097,-0.18692438399754124,-0.16885046907533466 +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:341799,EXECUTED,,-0.14790657120398665,127.0,120.0,7.0,1.0,0.008626939418790724,-0.15353390692695887,-0.13927963178519592 +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:5176,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:345895,pan_cancer_conditional,PAN_CANCER,ENTREZ:51134,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:345895,pan_cancer_conditional,PAN_CANCER,ENTREZ:613211,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:345895,pan_cancer_conditional,PAN_CANCER,ENTREZ:401089,EXECUTED,,-0.13815010630834096,127.0,120.0,7.0,1.0,0.008440698258757928,-0.1465908045670989,-0.1312767879455866 +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:79767,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:8326,EXECUTED,,-0.20106110876133212,111.0,109.0,2.0,1.0,0.020053497152356298,-0.22111460591368842,-0.18560361798441796 +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:51704,EXECUTED,,-0.09586676722466819,111.0,109.0,2.0,1.0,0.007803815281489435,-0.10367058250615763,-0.09059697361901477 +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:256957,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:84132,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3739,pan_cancer_conditional,PAN_CANCER,ENTREZ:1551,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3739,pan_cancer_conditional,PAN_CANCER,ENTREZ:124446,EXECUTED,,-0.13485433045118464,66.0,64.0,2.0,1.0,0.010604401783674833,-0.14545873223485947,-0.12777271410551308 +ENTREZ:7157,ENTREZ:3845,pan_cancer_conditional,PAN_CANCER,ENTREZ:3845,EXECUTED,,-1.0865308434948417,376.0,376.0,0.0,1.0,0.041821250320390746,-1.1283520938152325,-1.0543818091940387 +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:54888,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:79629,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:135250,EXECUTED,,-0.11458945150876651,163.0,162.0,1.0,1.0,0.014627248850409308,-0.12921670035917582,-0.10285821370486684 +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:23521,EXECUTED,,-0.3952742324314792,163.0,159.0,4.0,1.0,0.018802536040378126,-0.4113102301763582,-0.37647169639110106 +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:55284,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:171019,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:51466,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:124975,EXECUTED,,-0.13879081504209426,137.0,130.0,7.0,1.0,0.0037758290010070916,-0.14256664404310135,-0.13610281963851234 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:23276,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:50674,EXECUTED,,-0.11881770048111831,137.0,130.0,7.0,1.0,0.002846487448179613,-0.12166418792929792,-0.11633851389084549 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:100506658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:85315,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:5549,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:146325,EXECUTED,,-0.15078071625739745,137.0,130.0,7.0,1.0,0.002794061734333886,-0.15357477799173133,-0.1489382073768901 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:5868,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:944,EXECUTED,,-0.09063115875245041,137.0,130.0,7.0,1.0,0.002383378391192542,-0.09259182686042906,-0.08824778036125787 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:170261,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:7988,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:8233,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:64902,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:130813,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:1796,EXECUTED,,-0.15488103306656947,153.0,150.0,3.0,1.0,0.011064732073976985,-0.16088840684356534,-0.1438163009925925 +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:55890,EXECUTED,,-0.09207301119395929,153.0,150.0,3.0,1.0,0.007742126767096111,-0.0998151379610554,-0.08689458325676197 +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:79568,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:283748,EXECUTED,,-0.18804130947682957,153.0,150.0,3.0,1.0,0.016174061821885355,-0.2001709677942163,-0.1718672476549442 +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:80148,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:646658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:50837,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4741,pan_cancer_conditional,PAN_CANCER,ENTREZ:10207,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4893,pan_cancer_conditional,PAN_CANCER,ENTREZ:4893,EXECUTED,,-1.3350632067960595,187.0,187.0,0.0,1.0,0.07788993293853497,-1.4129531397345945,-1.2587829283724201 +ENTREZ:7157,ENTREZ:5290,pan_cancer_conditional,PAN_CANCER,ENTREZ:5290,EXECUTED,,-0.6206702665037975,349.0,349.0,0.0,1.0,0.08690709555491494,-0.6573355983666984,-0.5337631709488826 +ENTREZ:7157,ENTREZ:5395,pan_cancer_conditional,PAN_CANCER,ENTREZ:57224,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:546,pan_cancer_conditional,PAN_CANCER,ENTREZ:3973,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:546,pan_cancer_conditional,PAN_CANCER,ENTREZ:29993,EXECUTED,,-0.08832238394026756,186.0,186.0,0.0,1.0,0.006856030454213458,-0.09517841439448102,-0.08221361349010538 +ENTREZ:7157,ENTREZ:546,pan_cancer_conditional,PAN_CANCER,ENTREZ:9124,EXECUTED,,-0.14223934791633155,186.0,186.0,0.0,1.0,0.018111340732617345,-0.15450764562147057,-0.12412800718371421 +ENTREZ:7157,ENTREZ:54790,pan_cancer_conditional,PAN_CANCER,ENTREZ:343563,EXECUTED,,-0.23187525249115276,85.0,78.0,7.0,1.0,0.017729983956226075,-0.24960523644737884,-0.21923404338242147 +ENTREZ:7157,ENTREZ:54790,pan_cancer_conditional,PAN_CANCER,ENTREZ:641455,EXECUTED,,-0.20808043095061626,85.0,78.0,7.0,1.0,0.016962409289320468,-0.22504284023993673,-0.19771316211514817 +ENTREZ:7157,ENTREZ:54790,pan_cancer_conditional,PAN_CANCER,ENTREZ:142684,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:9847,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:3070,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:152404,EXECUTED,,-0.11532893673807437,163.0,160.0,3.0,1.0,0.010265418467701293,-0.12559435520577567,-0.10870170096304214 +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:654502,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:8581,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:4129,EXECUTED,,-0.07315444649928247,163.0,160.0,3.0,1.0,0.004957231461690165,-0.0764045100747829,-0.06819721503759231 +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:7709,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,pan_cancer_conditional,PAN_CANCER,ENTREZ:5728,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:57492,pan_cancer_conditional,PAN_CANCER,ENTREZ:201965,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:1871,EXECUTED,,-0.5449616367402317,251.0,251.0,0.0,1.0,0.06112382296081276,-0.597273591648888,-0.4838378137794189 +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:5925,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:6502,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:7027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:200894,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:64757,EXECUTED,,-0.1974744369246594,61.0,54.0,7.0,1.0,0.014354279030013017,-0.2074219143807014,-0.1831201578946464 +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:4650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:390260,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:79228,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,pan_cancer_conditional,PAN_CANCER,ENTREZ:133396,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:973,EXECUTED,,-0.08895512083944167,137.0,130.0,7.0,1.0,0.0022700872106413555,-0.09122520805008302,-0.08668898378257561 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:2793,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:10542,EXECUTED,,-0.07875000307456616,137.0,130.0,7.0,1.0,0.0035683729728258756,-0.08181537156855499,-0.07518163010174028 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:4061,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:56926,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:79751,EXECUTED,,-0.1808131138594748,137.0,130.0,7.0,1.0,0.004621857614966807,-0.1847006514342262,-0.176191256244508 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:6691,EXECUTED,,-0.08445849755687228,137.0,130.0,7.0,1.0,0.0022754105559307097,-0.08649936743165743,-0.08218308700094157 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:84885,EXECUTED,,-0.08191342192340997,137.0,130.0,7.0,1.0,0.002780892712805405,-0.08469431463621538,-0.08007723059574731 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:84107,EXECUTED,,-0.09630331063938441,137.0,130.0,7.0,1.0,0.0030516840966229586,-0.09935499473600737,-0.09343286313292043 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:10780,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:602,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:22943,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:3298,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:645745,EXECUTED,,-0.2553658145987826,76.0,69.0,7.0,1.0,0.009992124104016564,-0.26535793870279917,-0.2485304106368509 +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:266812,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:81832,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:283297,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:159090,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:84690,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:81930,pan_cancer_conditional,PAN_CANCER,ENTREZ:11319,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:81930,pan_cancer_conditional,PAN_CANCER,ENTREZ:57523,EXECUTED,,-0.1017390271880533,108.0,101.0,7.0,1.0,0.004424540420635753,-0.10616356760868906,-0.0974571392427932 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:8706,EXECUTED,,-0.10772951701101978,127.0,120.0,7.0,1.0,0.006401732315852046,-0.11413124932687183,-0.1034368902760606 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:94027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:4850,EXECUTED,,-0.216565427692534,127.0,120.0,7.0,1.0,0.013810881731684072,-0.23037630942421808,-0.2073660858090756 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:23219,EXECUTED,,-0.2145057659290111,127.0,120.0,7.0,1.0,0.0072235883441073845,-0.22101973819014237,-0.20728217758490372 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:2257,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:401089,EXECUTED,,-0.13743645042902433,127.0,120.0,7.0,1.0,0.0070057830540043164,-0.14444223348302865,-0.133035545725516 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:8514,EXECUTED,,-0.15055848715366613,127.0,120.0,7.0,1.0,0.006675754390263439,-0.15495295072414822,-0.1438827327634027 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:283078,EXECUTED,,-0.1815025660300816,127.0,120.0,7.0,1.0,0.00928491568509382,-0.18570467240800814,-0.1722176503449878 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:29943,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:390999,EXECUTED,,-0.20932182331362892,127.0,120.0,7.0,1.0,0.0072737973870317385,-0.21434003625464643,-0.20204802592659718 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:171017,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:84162,pan_cancer_conditional,PAN_CANCER,ENTREZ:440400,EXECUTED,,-0.4617484781692949,204.0,204.0,0.0,1.0,0.03430147344104695,-0.4939491091434202,-0.4274470047282479 +ENTREZ:7157,ENTREZ:896,pan_cancer_conditional,PAN_CANCER,ENTREZ:4804,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:896,pan_cancer_conditional,PAN_CANCER,ENTREZ:5557,EXECUTED,,-0.5040968774574668,44.0,39.0,5.0,1.0,0.024203553475771966,-0.5283004309332388,-0.4845603434388517 +ENTREZ:7157,ENTREZ:9699,pan_cancer_conditional,PAN_CANCER,ENTREZ:29980,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9699,pan_cancer_conditional,PAN_CANCER,ENTREZ:388585,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:2995,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:8284,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:119679,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:51341,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:200316,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:1742,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:5325,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:116369,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:83862,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:999,pan_cancer_conditional,PAN_CANCER,ENTREZ:136,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:999,pan_cancer_conditional,PAN_CANCER,ENTREZ:54785,EXECUTED,,-0.1445554626407886,83.0,81.0,2.0,1.0,0.011906190505561132,-0.1530301122419469,-0.13264927213522748 +ENTREZ:7157,ENTREZ:999,pan_cancer_conditional,PAN_CANCER,ENTREZ:7143,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:10350,pan_cancer_conditional,PAN_CANCER,ENTREZ:2815,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:10350,pan_cancer_conditional,PAN_CANCER,ENTREZ:4650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:9179,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:726,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:5553,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:163081,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:32,pan_cancer_conditional,PAN_CANCER,ENTREZ:9378,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:2815,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:4650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7157,EXECUTED,,-0.5935115896585543,96.0,96.0,0.0,1.0,0.1378111964707649,-0.6829957971344534,-0.45570039318778943 +ENTREZ:7273,ENTREZ:7403,pan_cancer_conditional,PAN_CANCER,ENTREZ:23515,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:7403,pan_cancer_conditional,PAN_CANCER,ENTREZ:23214,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:8209,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:55756,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:6007,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8085,ENTREZ:2261,pan_cancer_conditional,PAN_CANCER,ENTREZ:9441,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8085,ENTREZ:84159,pan_cancer_conditional,PAN_CANCER,ENTREZ:4502,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8289,ENTREZ:23039,pan_cancer_conditional,PAN_CANCER,ENTREZ:402381,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:10664,ENTREZ:27445,within_lineage,Uterus,ENTREZ:7737,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:10664,ENTREZ:288,within_lineage,Uterus,ENTREZ:152206,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:196528,within_lineage,Bowel,ENTREZ:6648,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:1850,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:440021,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:151011,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:10845,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:84331,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:346288,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:9618,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:288,within_lineage,Bowel,ENTREZ:731220,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:288,within_lineage,Bowel,ENTREZ:7314,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2956,within_lineage,Bowel,ENTREZ:80167,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2956,within_lineage,Bowel,ENTREZ:57535,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:341640,within_lineage,Bowel,ENTREZ:23435,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:4144,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:23787,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:50833,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:57683,within_lineage,Bowel,ENTREZ:23397,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:57683,within_lineage,Bowel,ENTREZ:6635,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1173,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1175,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:55726,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:81832,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7273,within_lineage,Bowel,ENTREZ:390326,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7468,within_lineage,Bowel,ENTREZ:401666,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7468,within_lineage,Bowel,ENTREZ:26595,EXECUTED,,-0.2288547916266943,39.0,34.0,5.0,1.0,0.013400075872697925,-0.23911880445688816,-0.21545471575399638 +ENTREZ:324,ENTREZ:79633,within_lineage,Bowel,ENTREZ:151011,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:80816,within_lineage,Bowel,ENTREZ:284119,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:8085,within_lineage,Bowel,ENTREZ:81930,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:8085,within_lineage,Bowel,ENTREZ:5204,EXECUTED,,-0.5257261101269711,39.0,39.0,0.0,1.0,0.027326487875779737,-0.5474334481155749,-0.4983996222511914 +ENTREZ:324,ENTREZ:8289,within_lineage,Bowel,ENTREZ:10276,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:64506,EXECUTED,,-0.20191983909934988,39.0,34.0,5.0,1.0,0.01436814150063423,-0.20918805831045695,-0.18755169759871565 +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:29926,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:81472,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:10490,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:10317,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:26735,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:338755,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:8771,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:123016,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2196,within_lineage,Bowel,ENTREZ:79934,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2196,within_lineage,Bowel,ENTREZ:84441,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:10845,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:84331,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:55291,EXECUTED,,-0.5131958432361028,28.0,23.0,5.0,1.0,0.020415259050815204,-0.533611102286918,-0.49852699867591954 +ENTREZ:3845,ENTREZ:2956,within_lineage,Bowel,ENTREZ:64746,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2956,within_lineage,Bowel,ENTREZ:339230,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1718,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7157,within_lineage,Bowel,ENTREZ:57646,EXECUTED,,-0.28917880847941246,28.0,28.0,0.0,1.0,0.01787910174561702,-0.3070579102250295,-0.2747754248193708 +ENTREZ:3845,ENTREZ:7157,within_lineage,Pancreas,ENTREZ:1106,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:84871,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10380,EXECUTED,,-0.4669074330805235,28.0,28.0,0.0,1.0,0.047313217984109035,-0.48117298292930266,-0.4195942150964145 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:91409,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:26235,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10841,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10046,EXECUTED,,-0.27996908753499905,28.0,28.0,0.0,1.0,0.015702411776843173,-0.2956714993118422,-0.26453438161826115 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4354,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4544,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:5173,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:6166,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:6519,EXECUTED,,-0.21133668829952312,28.0,28.0,0.0,1.0,0.010742478905193309,-0.2209349257192839,-0.20059420939432981 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:136895,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:159195,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:94025,within_lineage,Bowel,ENTREZ:81168,EXECUTED,,-0.41803292124767066,28.0,23.0,5.0,1.0,0.01886203996248842,-0.4345401689552804,-0.39917088128518224 +ENTREZ:4703,ENTREZ:1387,within_lineage,Bowel,ENTREZ:647174,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:64922,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:8605,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:83852,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10082,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:7273,within_lineage,Bowel,ENTREZ:90529,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:7273,within_lineage,Uterus,ENTREZ:5338,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:1387,within_lineage,Bowel,ENTREZ:140688,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:7273,within_lineage,Bowel,ENTREZ:9455,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:9575,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:22944,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:144195,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5728,ENTREZ:19,within_lineage,Uterus,ENTREZ:5592,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7157,within_lineage,Skin,ENTREZ:11200,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7157,within_lineage,Skin,ENTREZ:7157,EXECUTED,,-0.856907739031649,37.0,37.0,0.0,1.0,0.03591038215242648,-0.8928181211840754,-0.8228339747562092 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:567,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:23500,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:55096,EXECUTED,,-0.40543262619513415,11.0,0.0,11.0,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:79631,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:23219,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:2739,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4124,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:54538,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:673,within_lineage,Skin,ENTREZ:673,EXECUTED,,-1.1788788245383204,38.0,38.0,0.0,1.0,0.05589259301261573,-1.2347714175509361,-1.1452455038615954 +ENTREZ:7015,ENTREZ:673,within_lineage,Skin,ENTREZ:140890,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,within_lineage,Skin,ENTREZ:11200,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,within_lineage,Skin,ENTREZ:7157,EXECUTED,,-0.8069694294639463,38.0,38.0,0.0,1.0,0.042063842608238367,-0.8490332720721847,-0.7704476881392625 +ENTREZ:7015,ENTREZ:80731,within_lineage,Skin,ENTREZ:10494,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10060,within_lineage,Lung,ENTREZ:5500,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10060,within_lineage,Lung,ENTREZ:65263,EXECUTED,,-0.1190434454815338,86.0,81.0,5.0,1.0,0.0057522797172862156,-0.12319170442956184,-0.11329116576424758 +ENTREZ:7157,ENTREZ:10060,within_lineage,Lung,ENTREZ:6822,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1029,within_lineage,Lymphoid,ENTREZ:8572,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1029,within_lineage,Lymphoid,ENTREZ:6229,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10973,within_lineage,Bowel,ENTREZ:55295,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1387,within_lineage,Lymphoid,ENTREZ:9185,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:9465,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:9530,EXECUTED,,-0.11764068032426771,86.0,81.0,5.0,1.0,0.007161484914537414,-0.12135397988139435,-0.1104791954097303 +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:220972,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:54516,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:29935,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:23169,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Uterus,ENTREZ:5326,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:54964,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:2306,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:401494,EXECUTED,,-0.2918379373043891,39.0,39.0,0.0,1.0,0.015660226876898053,-0.30749816418128717,-0.2804130841744156 +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:4191,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:4646,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Esophagus/Stomach,ENTREZ:861,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:285601,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:54969,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:81875,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:1130,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:1954,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:56138,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:114088,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:153579,EXECUTED,,-0.08713101022687864,86.0,81.0,5.0,1.0,0.004189052146726158,-0.09111950484918963,-0.08294195808015248 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:10944,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:100190949,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:767,EXECUTED,,-0.07977965368626128,86.0,81.0,5.0,1.0,0.0032827059496313704,-0.08306235963589265,-0.07693920698879637 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:85016,EXECUTED,,-0.14113639835941594,86.0,81.0,5.0,1.0,0.00449709358998146,-0.1456334919493974,-0.13867922840798577 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:163747,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:26052,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:2108,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:442444,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:85302,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:152273,EXECUTED,,-0.2479910577134636,86.0,81.0,5.0,1.0,0.004692038559466177,-0.2526830962729298,-0.2436700854801561 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:389816,EXECUTED,,-0.10776318026585653,86.0,81.0,5.0,1.0,0.003251409826722687,-0.11083563540598493,-0.10451177043913384 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:4528,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:57084,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:408187,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:51298,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:50859,EXECUTED,,-0.14499390340250354,86.0,81.0,5.0,1.0,0.0030968172513307357,-0.1473373631526446,-0.1418970861511728 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:23648,EXECUTED,,-0.25923676628746384,86.0,81.0,5.0,1.0,0.009213649247004185,-0.268450415534468,-0.25161440666859236 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:284297,EXECUTED,,-0.14187543885651585,86.0,81.0,5.0,1.0,0.004384131688974252,-0.1462595705454901,-0.13856838954417505 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:10388,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:115572,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:9218,EXECUTED,,-0.22627615102580598,86.0,81.0,5.0,1.0,0.0052670829390402685,-0.23154323396484625,-0.2218907502058539 +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:146223,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:3060,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:79829,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:642658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:159371,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:6672,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:126374,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:220992,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Bowel,ENTREZ:5330,EXECUTED,,-0.21439323862488524,39.0,39.0,0.0,1.0,0.01360683976452498,-0.22786507281058885,-0.20078639886036026 +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:51496,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:2595,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:220064,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:55319,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:57583,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26278,within_lineage,Bowel,ENTREZ:94027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26278,within_lineage,Bowel,ENTREZ:55655,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:27445,within_lineage,Lung,ENTREZ:57106,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:27445,within_lineage,Lung,ENTREZ:729956,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2956,within_lineage,Bowel,ENTREZ:412,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:10286,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:84893,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:3693,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:115572,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:339479,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:57082,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:441670,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:85395,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,within_lineage,Bowel,ENTREZ:51704,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,within_lineage,Bowel,ENTREZ:158158,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:26269,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:54545,EXECUTED,,-0.0955127359811028,49.0,44.0,5.0,1.0,0.004149771857033802,-0.0996625078381366,-0.09177836131592551 +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:23168,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:54414,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:84773,EXECUTED,,-0.2426519282976816,49.0,44.0,5.0,1.0,0.010230040425879688,-0.25143068141879066,-0.2324218878718019 +ENTREZ:7157,ENTREZ:3845,within_lineage,Lung,ENTREZ:3845,EXECUTED,,-1.0159446991079832,86.0,86.0,0.0,1.0,0.0830461244324554,-1.0712496453336786,-0.9328985746755278 +ENTREZ:7157,ENTREZ:3845,within_lineage,Ovary/Fallopian Tube,ENTREZ:6484,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4089,within_lineage,Esophagus/Stomach,ENTREZ:4084,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4763,within_lineage,Lung,ENTREZ:55009,EXECUTED,,-0.151841360290641,86.0,86.0,0.0,1.0,0.01350573581783665,-0.16534709610847764,-0.14545043036658678 +ENTREZ:7157,ENTREZ:4763,within_lineage,Lung,ENTREZ:3449,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:10361,EXECUTED,,-0.10358606719021496,49.0,44.0,5.0,1.0,0.0036968298217403828,-0.10659292614913543,-0.09988923736847458 +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:5116,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:9197,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:53347,EXECUTED,,-0.14301327158736624,49.0,44.0,5.0,1.0,0.005857063296403009,-0.14664598044283506,-0.13715620829096323 +ENTREZ:7157,ENTREZ:4893,within_lineage,Lymphoid,ENTREZ:79705,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4893,within_lineage,Lymphoid,ENTREZ:4893,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4893,within_lineage,Skin,ENTREZ:6197,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Bladder/Urinary Tract,ENTREZ:10908,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:732,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:22943,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:343171,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:7799,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Esophagus/Stomach,ENTREZ:11170,EXECUTED,,-0.1650661356552155,49.0,44.0,5.0,1.0,0.00909554274940258,-0.17416167840461808,-0.16010629953293637 +ENTREZ:7157,ENTREZ:53353,within_lineage,Esophagus/Stomach,ENTREZ:10912,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:285016,EXECUTED,,-0.154557667146096,86.0,81.0,5.0,1.0,0.003774816532125358,-0.15713187690782712,-0.15078285061397065 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:145853,EXECUTED,,-0.13021118958579977,86.0,81.0,5.0,1.0,0.004863352944119603,-0.13507454252991938,-0.12634049899929833 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:23601,EXECUTED,,-0.08942858008461964,86.0,81.0,5.0,1.0,0.0030017136904192665,-0.0924302937750389,-0.08653804895487728 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:127602,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:10056,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:3667,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:4784,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:2923,EXECUTED,,-0.11018915410380575,86.0,81.0,5.0,1.0,0.004791210396896284,-0.113043006819279,-0.10539794370690947 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:5163,EXECUTED,,-0.09541090668103583,86.0,81.0,5.0,1.0,0.003098174248773844,-0.09735852955970875,-0.09231273243226198 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:10650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:5684,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:10556,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:55337,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:4184,EXECUTED,,-0.09473579634295122,86.0,81.0,5.0,1.0,0.003598758597001289,-0.09743609058310408,-0.09113703774594993 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:494197,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:84619,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,within_lineage,Lung,ENTREZ:138240,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,within_lineage,Lung,ENTREZ:54827,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,within_lineage,Lung,ENTREZ:727800,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,within_lineage,CNS/Brain,ENTREZ:5005,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,within_lineage,CNS/Brain,ENTREZ:5925,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,within_lineage,Lung,ENTREZ:10385,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:672,within_lineage,Breast,ENTREZ:79075,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:672,within_lineage,Breast,ENTREZ:8843,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:672,within_lineage,Breast,ENTREZ:113510,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:722,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:7813,EXECUTED,,-0.13653198419162485,86.0,86.0,0.0,1.0,0.008147148843735158,-0.14389742380171974,-0.1283848353478897 +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:171568,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:148867,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:6727,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:97,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:53822,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:133396,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:5036,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:23645,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:26191,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Bowel,ENTREZ:116987,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Bowel,ENTREZ:79837,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Head and Neck,ENTREZ:3785,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Head and Neck,ENTREZ:118987,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Lymphoid,ENTREZ:197259,NOT_PRIORITIZED,Original predeclared 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+ENTREZ:7157,ENTREZ:8289,within_lineage,Lung,ENTREZ:6300,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8289,within_lineage,Uterus,ENTREZ:939,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:896,within_lineage,Lymphoid,ENTREZ:4804,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:896,within_lineage,Lymphoid,ENTREZ:5557,EXECUTED,,-0.5040968774574668,44.0,39.0,5.0,1.0,0.024203553475771966,-0.5283004309332388,-0.4845603434388517 +ENTREZ:7157,ENTREZ:94025,within_lineage,Lung,ENTREZ:55509,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:952,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:23480,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:11231,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:6899,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:6597,within_lineage,Lung,ENTREZ:6532,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:94025,within_lineage,Lung,ENTREZ:79641,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8289,ENTREZ:10973,within_lineage,Bowel,ENTREZ:10658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, diff --git a/results/Paper_Experiment_Section/Figure_Index.csv b/results/Paper_Experiment_Section/Figure_Index.csv new file mode 100644 index 0000000000000000000000000000000000000000..c25e7cb0fe0a95416ab4f996cc7413489c9a65bf --- /dev/null +++ b/results/Paper_Experiment_Section/Figure_Index.csv @@ -0,0 +1,9 @@ +id,files,title,caption +F1_Study_Workflow,"['F1_Study_Workflow.png', 'F1_Study_Workflow.pdf']",End-to-end study workflow,All stages derive from raw upstream releases in the same fresh run. The therapeutic analysis is C1-selected but not an independent biological cohort. +F2_Primary_C1_Results,"['F2_Primary_C1_Results.png', 'F2_Primary_C1_Results.pdf']",Top primary co-mutation dependency associations,"Frozen pan-cancer C1, q_global_BY<=0.05. Effects are conditional associations, not causal synthetic lethality." +F3_Discovery_Drug_Evidence_Funnel,"['F3_Discovery_Drug_Evidence_Funnel.png', 'F3_Discovery_Drug_Evidence_Funnel.pdf']",Statistical discovery and therapeutic corroboration,Distinct statistical families and units: C1 gene-association rows versus PRISM drug comparisons; counts must not be interpreted as independent validations. +F4_C2_Effect_Stability,"['F4_C2_Effect_Stability.png', 'F4_C2_Effect_Stability.pdf']",Internal C2 refit stability,Model and lineage deletion sensitivity; no external replication asserted. +F5_Reactome_Enrichment,"['F5_Reactome_Enrichment.png', 'F5_Reactome_Enrichment.pdf']",Enriched Reactome terms in discovery contexts,"Source: pinned Reactome v98; labels are pathway associations, not molecular mediation." +F6_PRISM_Conditional_Sensitivity,"['F6_PRISM_Conditional_Sensitivity.png', 'F6_PRISM_Conditional_Sensitivity.pdf']",PRISM conditional pharmacological sensitivity associations,"A+B versus A-only (BH q<=0.05, expected direction); negative AUC contrast implies greater drug sensitivity. Other significant discordant tests remain in T7." +F7_PRISM_Four_Group_AxB_And_Bonly,"['F7_PRISM_Four_Group_AxB_And_Bonly.png', 'F7_PRISM_Four_Group_AxB_And_Bonly.pdf']",Four-group auxiliary testing and null evidence,Strict and pooled A×B and B-only contrasts are secondary tests. A non-significant interaction is not equivalence and does not negate the primary conditional comparison. +F8_TCGA_Selected_CoMutation_Prevalence,"['F8_TCGA_Selected_CoMutation_Prevalence.png', 'F8_TCGA_Selected_CoMutation_Prevalence.pdf']",Selected TCGA co-mutation prevalence,"Descriptive prevalence in selected TCGA study cohorts, different mutation definition from DepMap and no patient efficacy inference." diff --git a/results/Paper_Experiment_Section/Figures/F1_Study_Workflow.pdf b/results/Paper_Experiment_Section/Figures/F1_Study_Workflow.pdf new file mode 100644 index 0000000000000000000000000000000000000000..9dbfd5305ab64016dc8eb381872053845500bba1 Binary files /dev/null and b/results/Paper_Experiment_Section/Figures/F1_Study_Workflow.pdf differ diff --git a/results/Paper_Experiment_Section/Figures/F1_Study_Workflow.png b/results/Paper_Experiment_Section/Figures/F1_Study_Workflow.png new file mode 100644 index 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b/results/Paper_Experiment_Section/Figures/F8_TCGA_Selected_CoMutation_Prevalence.pdf new file mode 100644 index 0000000000000000000000000000000000000000..d13310de9b4a2b5870f5b3f599499b96d458fcb0 Binary files /dev/null and b/results/Paper_Experiment_Section/Figures/F8_TCGA_Selected_CoMutation_Prevalence.pdf differ diff --git a/results/Paper_Experiment_Section/Figures/F8_TCGA_Selected_CoMutation_Prevalence.png b/results/Paper_Experiment_Section/Figures/F8_TCGA_Selected_CoMutation_Prevalence.png new file mode 100644 index 0000000000000000000000000000000000000000..dd7a4da294f7196eee95bb7460c5b62a4e55ab1b --- /dev/null +++ b/results/Paper_Experiment_Section/Figures/F8_TCGA_Selected_CoMutation_Prevalence.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a7395ca2242a4cf602dac3ff311146983932f1500244b7e9f6b4e3f7a392e438 +size 95756 diff --git a/results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Claim_to_Evidence_Registry.csv b/results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Claim_to_Evidence_Registry.csv new file mode 100644 index 0000000000000000000000000000000000000000..6cf7c3c58bc5f49eb7239fd81d71e756d1645530 --- /dev/null +++ b/results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Claim_to_Evidence_Registry.csv @@ -0,0 +1,7 @@ +Claim,Statement,Observed_Records,Evidence_Location,Inference_Limit +C1,Conditional co-mutation dependency association,83,"C1 panel A+B vs A-only, pan-cancer BY q<=.05; T2/F2",OBSERVATIONAL_ASSOCIATION +C2,Selected C1 refit direction robustness,129,Selected original BY+precision refits; T3/F4,INTERNAL_SENSITIVITY_ONLY +Pathway,Reactome biological-context association,360965,ORA/GSEA source and FDR in T4/F5,NO_CAUSAL_MEDIATION +Therapy,Concordant conditional drug-response associations,8,PRISM AUC HC3 BH/FDR; T7/F6,OBSERVATIONAL_CROSS_ASSAY_CORROBORATION +Nonadditive,Strict four-genotype A×B BH significant,0,A×B source family; T8/F7,AUXILIARY_TEST_NOT_REQUIRED_FOR_CONDITIONAL +Clinical,Selected TCGA mutation co-occurrence,168,Selected study prevalence; T10/F8,PREVALENCE_NOT_DRUG_EFFICACY diff --git a/results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Section_Claim_Evidence_Methods.md b/results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Section_Claim_Evidence_Methods.md new file mode 100644 index 0000000000000000000000000000000000000000..7911a59774de5ec5613b6c25b3bbbbc28d3773fc --- /dev/null +++ b/results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Section_Claim_Evidence_Methods.md @@ -0,0 +1,47 @@ +# Evidence-aware Experiment Results + +- Fresh C1 BY associations: **83** (no historic result read). +- C1 BH primary associations: **278**. +- Drug conditional tests completed: **49**. +- Concordant BH drug comparisons: **8**; BY: **5**. +- Strict four-group interaction tested: **31**; BH significant **0**. +- There is no independent biological validation unless an independently genotyped non-overlapping cohort is verified by the authors. + +## Manuscript section plan +1. Data availability, cohort integration and feasibility (T1). +2. Directional C1 dependency associations and lineage effects (T2, F2, F3). +3. C2 robustness and underpowered C3 auxiliary interaction (T3, T6, F4). +4. Reactome and molecular coherence (T4, T5, F5). +5. Conditional PRISM pharmacological corroboration (T7, F6). +6. Four-group interaction and B-only sensitivity analysis (T8, T9, F7). +7. Selected TCGA prevalence and clinical limitations (T10, F8). +8. Consolidated interpretation and absent independent verification (T11, T12). + +## Reporting limits +All figures/tables must be inspected by the authors before submission. Negative AUC contrasts indicate increased sensitivity, but not proof of a drug working clinically. No causal genetic synergy claimed. + +## Figures +- **F1_Study_Workflow**: All stages derive from raw upstream releases in the same fresh run. The therapeutic analysis is C1-selected but not an independent biological cohort. +- **F2_Primary_C1_Results**: Frozen pan-cancer C1, q_global_BY<=0.05. Effects are conditional associations, not causal synthetic lethality. +- **F3_Discovery_Drug_Evidence_Funnel**: Distinct statistical families and units: C1 gene-association rows versus PRISM drug comparisons; counts must not be interpreted as independent validations. +- **F4_C2_Effect_Stability**: Model and lineage deletion sensitivity; no external replication asserted. +- **F5_Reactome_Enrichment**: Source: pinned Reactome v98; labels are pathway associations, not molecular mediation. +- **F6_PRISM_Conditional_Sensitivity**: A+B versus A-only (BH q<=0.05, expected direction); negative AUC contrast implies greater drug sensitivity. Other significant discordant tests remain in T7. +- **F7_PRISM_Four_Group_AxB_And_Bonly**: Strict and pooled A×B and B-only contrasts are secondary tests. A non-significant interaction is not equivalence and does not negate the primary conditional comparison. +- **F8_TCGA_Selected_CoMutation_Prevalence**: Descriptive prevalence in selected TCGA study cohorts, different mutation definition from DepMap and no patient efficacy inference. + +## Tables +- **T1_Raw_Source_And_Integrity**: Provider-verified DepMap 24Q4 v1 sources downloaded afresh for this run; no historical result artifact was an input. +- **T2_Primary_PanCancer_C1_BY**: A=conditioned mutant; B=additional mutation; X=target gene. HC3 β is A+B versus A-only CRISPR effect, negative is stronger dependency; BY q<=0.05. +- **T3_Original_Refit_Robustness**: Selected context refits with model/lineage deletions; unestimable refits retained. This is internal statistical stability, not independent replication. +- **T4_Reactome_ORA_GSEA**: Original release-locked Reactome 98 ORA and preranked GSEA, context-wise BH; associations do not prove mediation. +- **T5_Expression_CN_Molecular**: Unadjusted A+B versus A-only expression/copy-number contrasts where observed; not causal validation. +- **T6_C3_Four_Group_Original_Coverage**: All originally eligible C3 four-group gene-effect contexts; low genotype-arm counts and nonestimable models remain visible. +- **T7_PRISM_Conditional_Drug_Response**: All matched fresh-C1-target-drug candidates (including null, discordant, and underpowered); robust HC3, within-family BH/BY. Lower PRISM AUC indicates higher sensitivity. +- **T8_PRISM_Strict_AxB_Interaction**: A+B interaction is secondary; FDR applies over all estimable candidate tests. Absence of significant interaction does not invalidate conditional association. +- **T9_PRISM_AB_vs_Bonly**: Supplementary comparison among B-mutated models. Does not define the primary directional co-mutation estimand. +- **T10_TCGA_Patient_CoMutation_Prevalence**: Selected cancer studies only, any reported nonsilent mutation, not equivalent to DepMap damaging/hotspot. Not patient drug response evidence. +- **T11_Integrated_Candidate_Evidence**: Cross-assay observational evidence, compound-target annotation, TCGA descriptive co-occurrence; no causal synergy or validation inferred. +- **ST1_Expression_Pathway_Activity**: Mean z-scored log1p TPM of measured signature genes; not pathway activation or causal mediation proof. +- **T12_Noncausal_Interpretation_And_Failed_Evidence**: Negative/unavailable results are recorded; no independent/wet-lab validation claims. +- **Experiment_Claim_to_Evidence_Registry**: Counts measured freshly at run time; none copied from past experiments. diff --git a/results/Paper_Experiment_Section/Supplementary/ST1_Expression_Pathway_Activity.csv b/results/Paper_Experiment_Section/Supplementary/ST1_Expression_Pathway_Activity.csv new file mode 100644 index 0000000000000000000000000000000000000000..3ff424e6823f41ca34269a26db7e6acc31424455 --- /dev/null +++ b/results/Paper_Experiment_Section/Supplementary/ST1_Expression_Pathway_Activity.csv @@ -0,0 +1,7939 @@ +A,B,A_symbol,B_symbol,Pathway,n_genes_measured,score_definition,dataset,fit_status,beta_AB_vs_Aonly,hc3_se,p,ci_low,ci_high,n10,n11,n_total,n_lineages,adjusted_for,burden_not_adjusted_due_to_collinearity,fit_df_resid,mean10,mean11,q_global_BH,q_global_BY +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0426018649765227,0.03332044672516434,0.20148598343973548,-0.10802366331418024,0.022819933361134845,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06843985453172931,0.06269712983162766,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05803211865290875,0.03178085463771033,0.06828158708603649,-0.12043106186805075,0.004366824562233251,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.026297406174217434,-0.05236253322994277,0.6029135019899418,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009911008487422764,0.02316826253760413,0.6689421697404337,-0.03557785941615027,0.055399876390995806,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.008125240680896852,0.03597338044572321,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09976101155495137,0.03577523107971309,0.005440548742853352,-0.17000256541180606,-0.02951945769809669,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.1264703351744605,-0.019668968860681035,0.13931314813151582,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10157520222985301,0.02514579623016735,5.960159033504899e-05,-0.15094678549759577,-0.05220361896211026,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07732602582114324,0.009465366443111313,0.003112614632102756,0.02974630957888826 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08181662485852323,0.02819158317366536,0.0038242604323287977,0.026464903904135625,0.13716834581291082,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.029748652212092302,0.09044149878808869,0.10540617816606249,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09700326644181795,0.03420452915023539,0.004702623121750462,-0.16416088370783294,-0.02984564917580297,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07184836118072971,-0.01600554382027794,0.12484756635603735,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016471875607682585,0.024847410999097357,0.5076027283605875,-0.0323138542177276,0.06525760543309278,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.012981030864392945,0.10398742272336135,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039137857618533216,0.019851459583163058,0.04906234074000529,-0.07811447147578478,-0.00016124376128165419,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.055519780555722084,0.029545952676093157,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12860848530432253,0.03485732803004151,0.00024235447383817463,-0.19704781637873825,-0.060169154229906804,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.11574372366977231,-0.04472005672862575,0.010628783499046576,0.10157604515147735 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028439811121770582,0.02216121370570597,0.19981331216239143,-0.0719514262549941,0.015071804011452923,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05503330394651619,0.053895236095282996,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12211229813655523,0.03568966442617234,0.0006595417271079105,-0.1921858493132975,-0.052038746959812976,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.11918099506235784,-0.03803193387078309,0.02604203861514191,0.24887582764720492 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08219265056711404,0.025360616103224716,0.001248615771827638,-0.13198601396673798,-0.03239928716749009,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06489862465242523,-0.015438489104477844,0.043314562335282296,0.4139440736449076 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07415787589378872,0.020924207554798686,0.00042054194610729594,-0.11524073706658047,-0.03307501472099697,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04886999681452277,-0.014069651603122162,0.01747781135183097,0.16703011733956535 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15922941413415562,0.05435268197721144,0.0035066165823567455,0.05251265163833639,0.26594617662997483,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.041867362253873254,0.10597222358581576,0.0990587986859354,0.946674754347594 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19723148643051197,0.04346365049375522,6.7047737785246125e-06,0.11189438993013907,0.2825685829308849,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.16976858312629384,0.09671521082347326,0.00043270320531649085,0.004135212682087226 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09494057826913414,0.019799027819046053,1.99240556080727e-06,-0.13381424691899269,-0.05606690961927561,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.046925180398125,-0.07167309910301643,0.00015505603276164812,0.0014818232572164937 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024165173461427082,0.02284312233366166,0.29048306992021516,-0.06901565686105754,0.020685309938203382,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05725811058156672,0.05312326285147296,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.085358518846818,0.02249439154612472,0.00016085329457839732,-0.12952429968394819,-0.04119273800968782,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05708156884388069,-0.02664603617823522,0.007254849161155216,0.06933238277238057 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021091057823307263,0.02023410539433963,0.2976141628772995,-0.060818963441441415,0.018636847794826886,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03604903076120341,0.02194479157662932,0.8847007730863069,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11443992464018893,0.030414655053788497,0.0001824271626818183,-0.1741564538287259,-0.054723395451651946,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05116555037755165,-0.07270678661365616,0.008135431558248729,0.07774784041480882 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007707148054194894,0.0328120960209798,0.8143659143259456,-0.07213084400960405,0.05671654790121426,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03162219919819894,0.0208771392455774,0.9769437249386967,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03299258755577286,0.02384588429467639,0.16693647790729607,-0.07981190682772177,0.01382673171617605,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.031143951616398668,-0.06073114872265837,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06473026767895997,0.038195048692531666,0.0905786539626569,-0.13972292289965593,0.010262387541735987,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09273504688319678,-0.024796407328539938,0.6632964530955446,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0632575160888566,0.020394340765343046,0.0020025579763523703,-0.1033000299178233,-0.023215002259889907,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03667609141726461,-0.02787031543880958,0.06384058319793219,0.6101050004444529 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020893221250378874,0.022616920486171966,0.3559205294239659,-0.06529957700153756,0.02351313450077981,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04432531259571649,0.0976869730122281,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04214734665831906,0.018755974228149345,0.024946625977266913,-0.07897307032587102,-0.005321622990767105,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.009814260802964964,-0.06267597950168048,0.372930917151685,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010994244113156191,0.02411798878820961,0.648639725406455,-0.05834781688565187,0.03635932865933948,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04247782583674324,0.15613041535617903,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0604896828275692,0.02123076599733174,0.004514413661798833,-0.10217444483234941,-0.01880492082278898,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.024014678244284354,-0.04083332714560629,0.12065796514262335,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06387805986480073,0.01987824735275138,0.0013725520511380137,-0.10290726917716062,-0.024848850552440842,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08302575510528654,0.05668974133970641,0.04737094861710241,0.4527097212988421 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09914984464535724,0.021184391485642058,3.449328901946934e-06,-0.14074355433091756,-0.05755613495979693,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07558735186671024,-0.03278145391617982,0.00024447118592548894,0.0023363366298721016 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12441092581430836,0.03460903771480842,0.00034786515620070845,-0.19236276045548734,-0.056459091173129375,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05424708890676622,-0.07463489996716952,0.014845987150114105,0.14187857539985768 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053571973469212865,0.03415272563300522,0.11720023280133124,-0.120627879035941,0.013483932097515257,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06551031160906688,-0.004186464702277137,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05070181627340771,0.021152080698320804,0.01679472001038306,-0.09223208653903174,-0.009171546007783679,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.031622227439205945,-0.022744877993526244,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09507850371785367,0.03066539271648061,0.0020106054146281356,-0.15528733449344923,-0.034869672942258116,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07250174948591454,-0.07552617515103949,0.06384074312527256,0.6101065288213128 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020978403844733432,0.022412494034686755,0.34959402843767606,-0.06498338604306252,0.023026578353595655,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03425189326494409,0.10345356430959926,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08348516323823775,0.02538430874432584,0.0010571320603707608,-0.13332504507745493,-0.033645281399020566,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.049677312797725255,-0.03622673798398761,0.03797065291956154,0.36287395972779296 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021041230284852826,0.024312238755925763,0.38708850114785753,-0.06877619596962975,0.0266937353999241,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.030257930170070602,0.1476929483937824,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05298140558588784,0.017559870242655158,0.0026453373680683286,-0.08745868313639624,-0.018504128035379444,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.00660184611901304,-0.02843484036050227,0.07894243619446013,0.7544288077723469 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04272089362826334,0.01780692868207137,0.016699378689825677,-0.07768324893101258,-0.00775853832551409,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04640385129270479,0.019890535562393605,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05267097649043118,0.020226908004694084,0.009412661316034776,-0.09238475066015372,-0.012957202320708648,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.013636813742301331,-0.020131727278732237,0.19871730193267034,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03652925847552122,0.020234658657191925,0.07146701886755592,-0.07625825037713317,0.0031997334260907284,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.060804010286709446,0.011454642972004199,0.6190382519293574,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040234219211206276,0.019091642332599024,0.03544142171565132,-0.07771899799944201,-0.0027494404229705394,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.040476918567638125,0.011396013323360151,0.45085577817121814,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08865269524680056,0.01963876658493476,7.47504066517901e-06,-0.12721170490586425,-0.05009368558773685,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05976430133136543,-0.006664683620113138,0.00047852316774347564,0.004573100100975748 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05507916212320202,0.01652883569353454,0.000907311639351528,-0.0875320930343004,-0.022626231212103637,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03668070859022824,-0.0025426112593589048,0.03365532613631977,0.32163369660480573 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05030477406365386,0.018754766843073582,0.007488383234630566,-0.08712812713564946,-0.013481420991658263,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.034779300035228965,-0.0036554475257099123,0.1708126037830386,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07532293801920426,0.021546737870000332,0.0005029533179959198,-0.1176280833070959,-0.03301779273131262,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05874826594295723,-0.028982549621907695,0.02016385574874551,0.19269982516307485 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01700322807958757,0.014960015810330761,0.2561097969827943,-0.0463759176339711,0.012369461474795961,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03237412929265398,0.008006027821425557,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05534200496731107,0.017803540279820222,0.0019579066177863084,-0.0902977074370239,-0.02038630249759825,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03923173719358295,0.01943789018054011,0.06317830378856795,0.603775797935576 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061980219016699735,0.018389791737431372,0.0007925741788051308,-0.0980869752208161,-0.025873462812583375,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04435472986437047,-0.006860498865882217,0.03004088652499707,0.28709159861307076 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048811492330973046,0.018573663266670516,0.008780231592031123,-0.08527926428632288,-0.012343720375623216,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.07684820350681985,-0.17577280853814706,0.19294802921843934,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01068469465267676,0.025051033039379535,0.6698642966000159,-0.03850082933414791,0.059870218639501434,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03294426240400227,0.1994054613102579,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020656589777046836,0.04066473455153643,0.6116348130326135,-0.10049825832454047,0.059185078770446806,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.024185078385234197,0.006384962664966863,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03331523669706891,0.02623732440160155,0.20459702452367562,-0.08482994056881936,0.018199467174681544,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04555573580418021,0.08254398744303128,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011214556845138722,0.022884476521959192,0.6242539291345321,-0.056146235595765946,0.0337171219054885,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06343224632802866,0.08874164254165397,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16109575409273022,0.031845099336624084,5.418557151560242e-07,-0.22362083618503875,-0.0985706720004217,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.11758895182175351,-0.062327643068206894,4.675272464031e-05,0.0004468015431347066 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016720091693204014,0.02526837331193114,0.5083845039691816,-0.0663323443970475,0.03289216101063946,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03286236842066507,0.033294562627188905,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06930516814179988,0.031730921330390786,0.029287473606426827,-0.1316060716521103,-0.007004264631489461,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.12200406082373864,0.016152207570636293,0.4079068880915672,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06125168332140022,0.023536643702750413,0.009456492265782256,-0.1074638355943689,-0.015039531048431545,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07604250191989542,0.004468140848034989,0.19872601687461675,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12124437904284871,0.02300199933621957,1.8170586011710185e-07,-0.16640680361504412,-0.07608195447065332,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08186916324113888,-0.06098463950689406,1.7378085754331982e-05,0.000166077070192145 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049350700760612785,0.017759689199848938,0.005604575798069333,-0.08422030544975165,-0.01448109607147393,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.015049671989135028,0.013966985473020983,0.1422661633455176,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028521416150615646,0.020285186364383898,0.16016842816343613,-0.06834961480949718,0.011306782508265889,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04705007341583536,-0.05511718098867546,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06615068656362906,0.025442954350198548,0.009523206478246426,-0.11610571394793573,-0.01619565917932239,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.033247003047530574,-0.03391450700492332,0.1989347711166319,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06609624122360669,0.03027731897118307,0.029370520432277766,-0.12554312296189174,-0.0066493594853216445,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0758535269592861,-0.017374431479067073,0.4079068880915672,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012941162418128257,0.02803461678402319,0.6445040899130308,-0.06798469352219177,0.042102368685935254,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.016637569030313857,0.033187374434040684,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05138527530993591,0.02435604213316494,0.035239501388847606,-0.09920624511512235,-0.003564305504749475,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.027562325544925128,0.010745034803216565,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06298478621523278,0.026778048388352352,0.01894797313966801,-0.11556115459314452,-0.010408417837321035,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0432507097797554,-0.010437594903847418,0.3146632024742357,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041081451879592897,0.02572022022034199,0.11066996041533295,-0.00941796291920604,0.09158086667839183,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.013060051009377457,0.1801092244701467,0.7011158386088691,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08780924589694757,0.023590938457528403,0.0002136468127028766,-0.13412800119739593,-0.0414904905964992,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.01484297020310917,-0.03533659745188911,0.009474460330924216,0.09054453037322346 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010824407894298019,0.02394797639191802,0.651413569018172,-0.036195360328791955,0.05784417611738799,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.004397372584923853,0.08410851027649041,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10797423673159946,0.01914422822209483,2.4823200597073744e-08,-0.14556226333900094,-0.07038621012419799,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08307256287166138,0.0025286683388090103,3.1781704248317963e-06,3.037280631417158e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0979089645152247,0.020642956164238876,2.5608345574274315e-06,-0.13843961305091834,-0.057378315979531046,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.070290998619981,0.011779095266483913,0.00018822133997091622,0.001798773992251545 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0912228388390646,0.019959531676097327,5.769485914132587e-06,-0.13041164284875295,-0.05203403482937625,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03920551461425355,-0.01953835849635496,0.0003753949113638072,0.003587534779473621 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05850590692671805,0.03571693147156299,0.10186906808331146,-0.12863299457491054,0.011621180721474438,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09351531082597597,-0.03119428376306757,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006321980150504204,0.020197775497259974,0.7543725076921657,-0.03333459487533695,0.04597855517634536,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.005610278700474613,0.03522357516238987,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11105757968814503,0.026752642537183503,3.7207446097142155e-05,-0.16358406588754115,-0.058531093488748916,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.10766426238570026,-0.03651604993307709,0.001995626399453476,0.01907159340243874 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05802239101949407,0.01970794874635871,0.0033478524812840978,-0.09671723383381445,-0.01932754820517369,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05940865199328381,0.0020137549297892907,0.09525180285459917,0.9102924552359429 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10266542725394337,0.020197982999578583,4.792818163350111e-07,-0.14232240969253485,-0.06300844481535188,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08459989512024263,-0.006939004039194569,4.1808121517223276e-05,0.0003995474777817105 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08282549978712833,0.020391284399402142,5.429105070704491e-05,-0.12286201270746733,-0.042788986866789336,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05191309286476752,-0.047858316933198655,0.0028730824034168168,0.02745717305838057 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08644500897920875,0.01839778493476728,3.162443004739237e-06,-0.1225674591309032,-0.050322558827514303,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.041485094129264516,-0.05289940516294731,0.00022615741055513573,0.0021613174591382277 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09036070441133214,0.02151042576857678,3.009522618340767e-05,-0.13259455404715337,-0.048126854775510916,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06887089600604138,-0.013723023081771273,0.0016251422139040143,0.015530988933201399 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1182301825800469,0.01823187236109213,1.6950951996548615e-10,-0.15402687782736726,-0.08243348733272654,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04286526705446605,-0.09211520499039431,6.204534102939563e-08,5.929484180768225e-07 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09513984030208773,0.02014976699685108,2.83534249500728e-06,-0.13470215481401232,-0.05557752579016316,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04510928308650964,-0.02538842813150985,0.00020648576812264027,0.0019733215666538134 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0831364708282651,0.017520646531491855,2.535423545085604e-06,-0.11753673603428286,-0.04873620562224734,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03741912234471187,-0.04894011581162899,0.00018809525327934137,0.0017975690201606602 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.051251964687330204,0.01915283368111444,0.0076289366700712895,-0.08885688736486025,-0.013647042009800159,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03583403483822801,-0.006306209825881641,0.17308879679374334,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0841811911402577,0.01873326585919089,8.209469752824083e-06,-0.120962328900939,-0.0474000533795764,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04916199220497589,0.012482437224731814,0.0005171965944279173,0.004942690255428848 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1215864225195473,0.03111641696076506,0.00010246899295256123,-0.18268080016065613,-0.060492044878438456,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09145973014157104,-0.07835447332696104,0.004899993169020669,0.04682774161530534 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04982545207542778,0.024121995199780137,0.03924333925989927,-0.09718689108849299,-0.0024640130623625675,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06897034536078547,0.010171767694501238,0.47632053064997004,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07677970487520107,0.02416717037305842,0.0015543828642759175,-0.12422984141085527,-0.029329568339546863,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07092277650193954,-0.007200657773867176,0.051843240237908546,0.4954500495449042 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007042697016165885,0.019820968518382033,0.7224620015417398,-0.04595944432037696,0.0318740502880452,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.001108211694071465,0.031308932628697723,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1017889846554545,0.026491117113931314,0.00013310068919231678,-0.15380198843844428,-0.049775980872464695,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.085552463856703,-0.050216838261977696,0.006107244339934165,0.058365073188281984 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11065734569928026,0.020854597157625016,1.5111297491390826e-07,-0.15160353291317635,-0.06971115848538417,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.062437666804340014,-0.03646178494364962,1.4809071541563011e-05,0.00014152578417767157 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03845380184864164,0.021071528171080635,0.0684463179230215,-0.07982591423492622,0.0029183105376429444,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05194090360865803,0.008953859938268435,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08585843117314589,0.022024575296455667,0.00010633828041395571,-0.12910176867705417,-0.04261509366923761,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05328407013743585,0.013954898594990852,0.005054570478598685,0.048304989860929966 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08933706392504188,0.024052116667135408,0.00022025136016350314,-0.13656130251854123,-0.04211282533154254,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07924934632600152,-0.03428854160111991,0.009713084983210489,0.09282499346263162 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002295947339763185,0.021411911236175866,0.9146396535181596,-0.03974447758224129,0.044336372261767655,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.021145270634658923,0.10419902850731087,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018106689435633132,0.018729856292176366,0.334018881474608,-0.01866775393684014,0.0548811328081064,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.022391640412894164,0.045181945024078886,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11252459042525734,0.02566265795268636,1.3425714450823775e-05,-0.16291098671930793,-0.06213819413120675,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09024473388685865,-0.021252016685926817,0.0007894320097084379,0.007544361165072067 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05583522777736052,0.019262469393447234,0.00386681560966721,-0.09365541063798483,-0.018015044916736216,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.056858075501944376,-0.0007046870373286625,0.10548035157916945,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054402566374456535,0.019845789226148054,0.006279015075427912,-0.093368046979018,-0.015437085769895068,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0038235495300302383,0.010368346276613392,0.15242453109708493,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.069727811172912,0.020942189341746287,0.0009162379269117816,-0.11084597801999857,-0.028609644325825433,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05539729431539164,0.03538339407192185,0.03382835657593359,0.3232872957912386 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019203658580544646,0.01629404832033119,0.2389767413778222,-0.05119560491035476,0.012788287749265471,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03647431971916974,-0.004254797437533096,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08666736655711019,0.022068133331595286,9.456364735147727e-05,-0.12999622647355974,-0.04333850664066065,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.019782174664574468,-0.030268115385980735,0.004549371107127434,0.043476953409565144 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07102506416624972,0.02707040953089667,0.008890170157396475,0.01787467011974283,0.1241754582127566,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.05550010605350198,0.0020286762430066422,0.1944081837724882,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0908306176886351,0.02205022495577818,4.262887498446929e-05,-0.1341243160671579,-0.047536919310112266,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04131178563383514,-0.009289057838110189,0.002271060467293404,0.021703832859915062 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08341949719469736,0.027193005929918183,0.00224179570214308,0.030028395784334777,0.13681059860505995,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.05264838174602915,0.04747680733931384,0.06924270149265281,0.6617313988810555 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08756659365775425,0.021617691459533794,5.6872922544661954e-05,-0.13001105014588515,-0.04512213716962335,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02298955347537629,-0.007835589333541223,0.002989783173241898,0.028572446755133162 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09440147277674864,0.027923765552417292,0.0007638543571748171,0.03957558842212456,0.14922735713137272,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.04934779670059063,0.03154785625639507,0.029292154044703856,0.2799361904488662 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0448933814211912,0.0166134141214007,0.007057025212342059,-0.07751237471726347,-0.01227438812511894,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.027225149263588308,-0.02193531539151624,0.16360251162401113,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10564433712330226,0.01777711556303787,4.451219248264277e-09,-0.14054815696050646,-0.07074051728609806,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02763722597863447,-0.0748165761028773,7.361203831817048e-07,7.034878195204077e-06 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059038639385248656,0.017118428374145872,0.0005972852537668631,-0.09264918423143222,-0.025428094539065096,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03824474304038517,-0.003592225451848884,0.023706251722006796,0.22655342405862833 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08707235641218193,0.020399737373972097,2.2456340405553907e-05,-0.12712546601269842,-0.04701924681166544,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04653251326982971,-0.019887881598825503,0.0012553410573189218,0.011996911963647416 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016694067939084678,0.03201692154897123,0.602246022862148,-0.07955650799717388,0.04616837211900453,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03720298043456784,0.08797145882821494,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06896485927230218,0.025409817950717825,0.006811769731865177,-0.11885482621902393,-0.019074892325580427,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07624448354018751,0.01989197683094488,0.15903478862219345,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03265169781415509,0.016120515177938704,0.043203624665534165,-0.06430292691588774,-0.0010004687124224518,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.00773034767584567,0.009133456276967775,0.4971708399879019,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055585976214416535,0.019846461863637435,0.0052405240497306075,-0.09455277748417039,-0.016619174944662682,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05927182375956854,0.01989079646605857,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08036260689811982,0.022034713987572025,0.00028523167398541093,-0.12362585083999074,-0.037099362956248896,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03675355980559019,0.011422239342666151,0.01230526645704452,0.11759768193169373 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05448111896816991,0.021663998958765474,0.012135795711239268,-0.09701649620238938,-0.011945741733950438,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07466869165698396,0.02436577401089461,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06475981700426198,0.022135863925449653,0.003551429749778959,-0.10822166004932857,-0.02129797395919538,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04119942440202874,-0.027043909443033583,0.0996157220980402,0.9519971016942069 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09320713625596133,0.022020775789789844,2.621992247204308e-05,-0.13644301375908016,-0.049971258752842494,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07429800639982896,-0.01615752383346711,0.0014354051350557102,0.013717729486366907 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013223685063665045,0.023500172833776072,0.9551425638849877,-0.04481817638825822,0.04746291340099122,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.002997237762207727,0.030980051829111326,0.9948722834429907,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09819377032982055,0.029883307806256296,0.001068061798104813,-0.15686704542389582,-0.03952049523574527,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.10412535556576076,-0.0028556756980812705,0.038190425916018046,0.36497426328681687 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03970229812080323,0.02564725188106021,0.1220781669836748,-0.09005844593351098,0.010653849691904513,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.041113224927625945,0.07617731512361106,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08560740687408905,0.03588024283047875,0.01730554319951125,-0.15605514216777563,-0.015159671580402462,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08213331916201554,-0.0761454441341196,0.29669849226289485,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06408016669500198,0.030630860263845438,0.036802776248245246,-0.12422119600409748,-0.003939137385906476,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02400633599417384,0.02297782244899776,0.46006368166704054,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0904241622116837,0.024016678331812737,0.0001807192420928004,-0.13757882071683594,-0.043269503706531466,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08322579783922349,0.0009708326038443513,0.008104798552161861,0.07745509010997063 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08047823194524201,0.02048851555489579,9.429310669021328e-05,-0.12070564978049136,-0.04025081410999264,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03394089308109183,-0.008127489634332262,0.004549371107127434,0.043476953409565144 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03132303550455532,0.019102784070328265,0.10152183300407852,-0.006183619116404561,0.06882969012551521,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.06304617485410746,-0.007997464396095952,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15399701515320874,0.03004472796331413,3.857074476494543e-07,-0.21298722468246056,-0.09500680562395691,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05361022557839313,-0.0680704169489276,3.4792564993651915e-05,0.000332501941830682 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06299586876733859,0.020518220256602403,0.002222940325653151,-0.10328160920014373,-0.02271012833453346,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.024390903287788163,-0.030672915720640147,0.06892851681654183,0.6587288316682212 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09082087869646216,0.031611709167746214,0.0041908609164024255,-0.15288771949662172,-0.028754037896302598,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.1082945661099173,-0.007921276690453205,0.11353943329147595,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04984902906794816,0.020995638182554816,0.017857359681767982,0.008625920071868236,0.09107213806402809,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.020234282540563666,-0.009027504315454305,0.303536876132493,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08441331961593039,0.017627118014814286,2.0546975686952434e-06,-0.11902263231666169,-0.049804006915199095,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02663998848961669,-0.02037061142045156,0.00015835135243012468,0.001513315623155056 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014301311475916395,0.019594692405368316,0.46572603124489564,-0.05277378531776022,0.02417116236592743,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04833735212965087,0.043134571547933875,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0984568953765324,0.02058500542691561,2.1138564535698945e-06,-0.13887376268108134,-0.05804002807198347,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03698237019874363,-0.05273930882453895,0.00015979389461704454,0.0015271015592713227 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02036671124568186,0.01871745866047823,0.27692566781835026,-0.01638339045551942,0.05711681294688314,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03128770906209728,0.07616693773568062,0.8725380346331878,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10241837035144587,0.01820397425055315,2.6810191209719886e-08,-0.13816029008579855,-0.06667645061709318,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0315253161054004,-0.025230998063695186,3.3253015284805694e-06,3.1778893438700457e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06639502232978146,0.019528327999977824,0.0007128855687602605,-0.1047371954352016,-0.028052849224361333,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05956674392313225,0.014614144151333037,0.027604320218629012,0.26380607688121777 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07483101243346907,0.02976531968432637,0.012162736028722207,-0.13327262811484777,-0.016389396752090356,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09069395795673017,0.005804843534588148,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07887545473595832,0.023882956069593123,0.0010074702130506998,-0.12576756121279156,-0.031983348259125084,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.050324172167545214,-0.02407206556808739,0.03644649474155011,0.34830804445427466 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05139529783549876,0.017055012484378844,0.0026772520215340074,-0.08488133109917079,-0.01790926457182674,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.025447136753611734,-0.0063369745065469905,0.07911164839882295,0.7560459172479591 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07167784727771037,0.031510790481380224,0.023229954267981218,-0.13354654301689897,-0.009809151538521764,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.060529022161593116,-0.029380895872191126,0.36015503316256814,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058915180421038826,0.022703058484030727,0.009659473033252113,-0.10349066063717263,-0.01433970020490502,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.042294117615348785,0.025165385426642452,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0024740401551894835,0.024190107495872717,0.9185682573118553,-0.049969211736009204,0.04502113142563024,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.006028236679861299,0.007839701234488641,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11562947509366903,0.025890456962208493,9.307165099477486e-06,-0.16646313492489243,-0.06479581526244563,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07260896223548238,-0.013345966989155113,0.0005639715767912388,0.005389704508840115 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05951524097941378,0.030465236598086306,0.05115925256287308,-0.11933108262969394,0.00030060067086638137,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.006818476479368623,-0.12531670680786208,0.5315473126231498,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05241726860174421,0.030277581849342705,0.08385951958026047,-0.11186466647842587,0.007030129274937444,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02566144183169831,-0.041563830015590886,0.6500804664849935,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044438881509493725,0.026272124714581575,0.0911965771886284,-0.09602191276822808,0.007144149749240623,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04872165640263467,0.00940849315644027,0.66475521554025,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08274656862651696,0.028218751900367215,0.003475918450844449,-0.13815163301216288,-0.027341504240871048,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0900870561180848,-0.02854528563335323,0.09854228808144014,0.9417386198889203 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007175046183237898,0.025438285256754005,0.7779845114402947,-0.057120906208767294,0.042770813842291505,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.011362524595874003,-0.04597292850383239,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24302067505320735,0.06267512530377488,0.00011565239629370065,0.1199635191203511,0.3660778309860636,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0791995863400633,0.7118341552540602,0.005436114064320203,0.05195128564764741 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07700214270336321,0.022514043818803703,0.0006626973797252035,-0.12120650906819311,-0.032797776338533306,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08328733451466624,0.013709147984518597,0.02604203861514191,0.24887582764720492 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07640796791636882,0.021642058137610356,0.00044233551747731265,-0.11890026625705447,-0.03391566957568318,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0822094881920493,0.023731049857769457,0.018006458142230296,0.17208223362884745 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007861898073772375,0.026141649074231266,0.9760165668623757,-0.05211304349738384,0.05054066388262937,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.030953433986626963,-0.007766025772292216,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06672106795817245,0.02052282711925969,0.0012057045224398832,-0.10701585356501803,-0.02642628235132688,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06336170885454687,0.012253314922617456,0.04234903760676014,0.40471684802421154 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03126302958668392,0.023687561265680786,0.187337515974149,-0.07777149536496299,0.015245436191595144,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.0018588704966681668,-0.02893547230556922,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011220973498920626,0.025784024856455184,0.6635601375262515,-0.0618456631498617,0.03940371615202044,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.019977946099134475,-0.008686388567308191,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08088573259543838,0.020534075887971532,9.011672082804851e-05,-0.12120260418103097,-0.04056886100984579,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06423449499247359,-0.017675919191980905,0.004415719320574377,0.04219968401117099 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11416178475898245,0.019422408091212606,6.475388923994018e-09,-0.15229599333834634,-0.07602757617961856,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06373993438068684,-0.060814654478495565,1.0280327455732904e-06,9.824595692528385e-06 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09110291704284254,0.02156825299354676,2.7233175128585185e-05,-0.13345030540404812,-0.04875552868163697,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06880062805151743,-0.009971811124793072,0.0014806640011692412,0.014150254678762169 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06589360591127065,0.026510231575129203,0.013169688302419007,0.013843072546635804,0.1179441392759055,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.02152590686068659,0.05875031173802237,0.2450248350502534,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10449933078581623,0.036505013181639775,0.004329353271158797,-0.17617374831033064,-0.032824913261301825,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0729012885523727,-0.008069039493404115,0.11689253832128753,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0352525791432749,0.026925208071945185,0.19087669306954502,-0.0881178827573452,0.017612724470795392,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.007952284993791652,-0.0026637965610030933,0.8119931348263925,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015510865170294324,0.027950122688604768,0.5791103248428537,-0.07038849946880835,0.039366769128219695,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0382036195248297,0.02697816676621987,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10327768449041065,0.03287697744222214,0.0017537720279328947,-0.16782876947188502,-0.03872659950893627,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.059743498300584924,-0.04293465610505765,0.057765320986437003,0.5520455707122307 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07879253534759546,0.019609200780580958,6.511900058288584e-05,-0.11729349512197187,-0.04029157557321906,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05792018241060499,0.014166023032618926,0.0033565884845905706,0.03207789334464142 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05432151877732037,0.03283504423923802,0.09850652554766995,-0.010147234008193166,0.1187902715628339,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.06047822902467577,-0.030097385524673708,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11885804773088685,0.029792292949754676,7.328408481132888e-05,-0.17735262307231797,-0.06036347238945573,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09190298800574052,-0.050146267405950254,0.0037290324694380043,0.035637227018589394 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08872328376656621,0.01798318466876271,1.0127179423210421e-06,-0.12403170236529214,-0.05341486516784029,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.031210045770499874,-0.04816990055573497,8.373911485567118e-05,0.0008002692041179875 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06317332190729279,0.02024558553050071,0.001881774366716268,-0.10292376777403206,-0.023422876040553514,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0526672706404868,0.04973673132754674,0.061219364438498916,0.5850548114850131 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06376131963905293,0.020960118042806127,0.0024391389367877684,-0.10491468793091208,-0.022607951347193796,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.008820580883062415,-0.03159784034100728,0.074183466974028,0.708948789061601 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03984289534742638,0.025905909801252684,0.12451142299393221,-0.09070689548374929,0.011021104788896521,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05380950374736056,0.0886360392697917,0.7259506085296737,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021500577511007927,0.022479682493330478,0.3391829764252574,-0.06563747840263257,0.022636323380616715,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.013461616876632653,-0.028099127131980664,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08661689794600387,0.018769954921820632,4.696046997305545e-06,-0.12347007148928912,-0.049763724402718625,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.049299059442273516,0.014423988796564929,0.00031325395852614636,0.0029936726284795524 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05094213541427029,0.018701130837889355,0.0066128368050824655,-0.08766017885630376,-0.01422409197223682,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.01655607782194262,-0.014365477594647038,0.1564101093868082,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11138126671471574,0.020156095834788786,4.651043889306511e-08,-0.1509560073493357,-0.07180652608009577,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.057647167209374114,-0.052172182096755164,5.274283770473584e-06,5.0404722841460266e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018197213780818417,0.015826070314246786,0.2506148380117972,-0.049270326008761856,0.012875898447125018,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.018738651138616502,0.019804274894825648,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10112014465293015,0.019701382948114746,3.720444534371902e-07,-0.13980209609360883,-0.06243819321225147,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.060205088344584365,-0.028381696148691474,3.3945849096372593e-05,0.0003244101360073502 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012302593873291646,0.016024975414128572,0.4429202821628613,-0.043766238960537066,0.01916105121395377,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.009924540291475143,0.05083482989359828,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03066313814240411,0.01708322380404301,0.07310353010468774,-0.06420456187791258,0.0028782855931043655,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03815962390159323,0.05782815382794737,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1729792225748024,0.029513535952365364,7.132395556808403e-09,-0.23092648280311884,-0.11503196234648594,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.030612480659556532,-0.14009674149187656,1.102272258046489e-06,1.053408009134766e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10711371714901644,0.023086468024452116,4.177093029544343e-06,-0.15244198864196223,-0.06178544565607065,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.042186902662410306,-0.011049904440459236,0.0002833996963121624,0.0027083645415396217 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017205712548321768,0.016637663115283995,0.3014324390658877,-0.049872316634273564,0.015460891537630028,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.027342862153138154,0.02196243492961507,0.8896367821404172,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10305553864060928,0.02154351996445134,2.1071920174375705e-06,-0.14535436585090633,-0.06075671143031222,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06047387915896961,-0.019639857361547594,0.00015979389461704454,0.0015271015592713227 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018307835686731583,0.018775328091870762,0.3298525276435518,-0.01855588760849286,0.055171558981956026,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.00499744649702022,0.058054331779730205,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08259330155002541,0.017776482445645454,4.050865652557982e-06,-0.11749587831630945,-0.04769072478374136,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02860637744163155,-0.02841020103288675,0.00027720492715521775,0.0026491630203452883 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056343650682681046,0.016868228334200788,0.0008822425774889652,-0.0894629495172978,-0.02322435184806429,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03536873530314591,-0.030914451708894886,0.03287906845120848,0.3142152384454954 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0017063085781817999,0.027279662436187912,0.9501439874713483,-0.05526755249967532,0.051854935343311724,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.043884327608139956,0.19313791762856516,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008530678414478745,0.023824793453214466,0.7204089318557032,-0.05530858765407502,0.03824723082511754,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.011100700826474089,-0.04312379954641646,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07608516512806703,0.0773842189135222,0.32724855047007895,-0.2291171611748719,0.07694683091873787,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15483787612709404,-0.029534002802257826,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028350020045819962,0.06789868246883092,0.6769461581923253,-0.10592375118349354,0.16262379127513346,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2262932635370521,0.08666385536206861,0.9619695749374265,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0014671163872300066,0.04934981526189392,0.9763268346558014,-0.09612514260433863,0.09905937537879864,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.19550640394468383,0.09014189272637055,0.9980529036429133,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07386483102524237,0.08203119724599182,0.36947358277892506,-0.08835684710130005,0.2360865091517848,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03963477255021657,-0.044551549785885824,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019692248336159582,0.05797919794900241,0.7346490848383616,-0.09496513938321476,0.1343496360555339,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10659767970931867,-0.003485721799099341,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05486328111293757,0.05937129871561408,0.3570861222653867,-0.1722736327053587,0.06254707047948357,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.25043642397627086,0.08352184884755817,0.911668967477982,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019647339973278766,0.07496322317555017,0.7936462632942575,-0.12859698986193466,0.1678916698084922,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11910659412861593,0.018444750723830713,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001267876646221512,0.04346929797383569,0.9767740181342821,-0.08469530201069966,0.08723105530314268,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.144394416855315,0.09026016628226291,0.9980529036429133,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014324638082204164,0.04157210487004909,0.7309474288120663,-0.0678867259071406,0.09653600207154892,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07755737718919994,0.018351597576542998,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023585902561783115,0.07186664180777756,0.7432728571634194,-0.1185347494191491,0.16570655454271532,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06567580400478254,-0.037017903134065805,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02503429321671365,0.04831714905099781,0.6052133664850761,-0.07051580558092548,0.12058439201435277,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09806511345580601,-0.006257385520638368,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04346263750153447,0.08009013033719764,0.5882441486575816,-0.11492046284153082,0.20184573784459978,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.025761744360538526,-0.10646411429239995,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017770268525869968,0.0488878423082517,0.716802878391567,-0.07890841087275206,0.11444894792449199,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09008699357116372,0.013480355420789545,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013594698659779863,0.041606092808232006,0.7443609835716987,-0.06868387854299102,0.09587327586255073,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.091140467491578,-0.0006820531793783069,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08989256108803367,0.12025638625127641,0.45604774355795064,-0.32770687366737283,0.14792175149130546,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.17462607316985845,-0.016672775940463798,0.9351865121061772,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025756300002480813,0.09574789444534593,0.7883364074147395,-0.21510358049418427,0.16359098048922266,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.44151513666382747,0.34341627433213534,0.9726336318937702,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01020047705774096,0.03607550131278422,0.7777956390805694,-0.061141019332549604,0.08154197344803153,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03969234820653993,0.0020292387643376982,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03692799553392119,0.055294152601991366,0.5053634592929565,-0.0724195518239646,0.146275542891807,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10269157904171884,0.025137759389116603,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008338603954791935,0.0450107484060219,0.8533026307093138,-0.09735009452538995,0.08067288661580607,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06447717099086839,-0.01942010755921984,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03573707023614447,0.045453053325092814,0.43309390246905244,-0.05414910519368025,0.1256232456659692,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08525515120759673,0.0336335824906777,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034029666319734815,0.06378235003835131,0.5945390525263766,-0.16016313999131956,0.09210380735184995,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15715908660620612,-0.05618829872586521,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015641390151843272,0.08303402723669018,0.8508648547243265,-0.14856344522984527,0.1798462255335318,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.19774768754331862,0.09838831185500298,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019275578987728505,0.042286887509194224,0.6492401278103185,-0.10290046908800063,0.06434931111254363,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.22777927644759055,0.08337169011371875,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09064350269814367,0.09651374190394461,0.34930481170917294,-0.10021828768849975,0.2815052930847871,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.162275663297333,0.010644228735379312,0.9086977961712401,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07514920861368608,0.050581300639473324,0.1396699153055878,-0.024878387557469933,0.1751768047848421,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14644275849107746,0.09242158706336714,0.7562754349902838,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003915396746684489,0.04939166942780112,0.9369324733934223,-0.10159042489508614,0.09375963140171716,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05975228610126056,-0.0014492733953949777,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02685702922957435,0.04571849872624713,0.5578800219345643,-0.06355408061388688,0.11726813907303558,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.18927602566933946,0.1045227002911872,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020584394292939377,0.04336869785074282,0.6358068964279546,-0.10634863009231668,0.06517984150643794,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.037648804635605895,-0.022854578211249737,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01910238788891367,0.04907592436559273,0.6977062820413372,-0.07794823520907751,0.11615301098690484,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11626642450218211,0.04527217118028032,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02375119814037153,0.04038572546459776,0.5574346472334378,-0.05611402847065418,0.10361642475139725,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03514471105039977,-0.027598749130880854,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02962886346321181,0.038102840180656045,0.4381539792755783,-0.045721818752943344,0.10497954567936696,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03986086609017491,-0.031161598283463092,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010473115483377963,0.07701993814554393,0.8920387336871483,-0.16278472417178005,0.14183849320502415,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2055654255412462,0.07473435660441222,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0547117494182232,0.08719786598463247,0.5314204804174615,-0.11772733015124628,0.2271508289876927,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15919913650645598,0.022287279473194768,0.9462574637850627,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01240554809018327,0.04498762264712182,0.7831550409813428,-0.07656020988668616,0.10137130606705269,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10015808175464054,0.024721378161409454,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007930102511179704,0.06372351188890411,0.9011463204672487,-0.11808701514389391,0.13394722016625332,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1023703560067122,-0.011161211890442805,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09644973209520623,0.041741868194676394,0.02235820929954375,0.013902650813782946,0.1789968133766295,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07053859939104387,0.1786579128778234,0.34868264326086107,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036060566880842734,0.061359321548836755,0.5577115674766369,-0.15740235445111708,0.08528122068943161,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.16036966468582875,-0.008623443013991525,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049577177198753125,0.04135993752577253,0.23273834467407417,-0.032214612972487,0.13136896736999326,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.047034152843366615,0.10311665601486908,0.8439821745193242,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017312356932089396,0.048668811176737395,0.7226031477124196,-0.11355788895618688,0.07893317509200809,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08426296745431158,-0.017806042535800447,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015781990083712467,0.03871910440163194,0.6842066879985895,-0.06078739208383151,0.09235137225125643,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07543718978129661,0.0049749759222231845,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02691323963327111,0.04662203366097784,0.5647152589598801,-0.11911114472389221,0.06528466545735,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.13201668642205497,0.010217224410534085,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04187498331670684,0.04895314600167172,0.3938290126618351,-0.05493283810458601,0.13868280473799968,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.039290538216520454,-0.019709529276006842,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0051670607614215215,0.04415504666554275,0.9070161728321436,-0.09248634913362831,0.08215222761078526,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09147348291778666,0.024306664457519778,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022959462865400678,0.03613781811510717,0.5262803280037902,-0.04850526878888335,0.09442419451968471,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.013659273061574485,-0.03511656150442312,0.9448126253726593,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019008870989658384,0.040272414495876825,0.6376780716680258,-0.09865001827338947,0.06063227629407271,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.009919271925759143,-0.036906703651738856,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021912227770123444,0.036697645567006616,0.5514322416762016,-0.05065959669466899,0.09448405223491588,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04583936531381047,0.036396388780527617,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0417758354104828,0.041827222573153806,0.31967916457015905,-0.040940039341923626,0.12449171016288922,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04602397290742257,0.014832057923457006,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004452965205470151,0.03777246053821485,0.9063293837528378,-0.07915030159936526,0.07024437118842497,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03691352721148126,-0.012915337676765991,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026981572683384858,0.035018536560830524,0.44234331786539505,-0.09623285703802321,0.0422697116712535,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.027400923332464685,-0.03188418893967874,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01568309013020682,0.04614735993890041,0.7344952555122579,-0.07557611882597823,0.10694229908639188,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10796202013021118,0.02249180102496242,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.245307753430527,0.0957053263802637,0.011459905409079079,0.05604465387466348,0.43457085298639053,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1299618365084106,0.6191679563115371,0.22274190244438216,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10844821394461417,0.07957283309367681,0.17517270769124949,-0.26580832754907885,0.0489118996598505,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14679504794360826,-0.21057102977799463,0.7896200758961603,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014790568884537997,0.09663535916038052,0.8785813993482575,-0.20589286478725985,0.17631172701818384,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20802890553937559,-0.024863781103340206,0.986191362849829,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018671402385732283,0.049924767314246395,0.7089935975951782,-0.11740066400442611,0.08005785923296155,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12164482350720185,0.01337167413251599,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030593903867633648,0.05529884669287919,0.5810028284052396,-0.07876292634027343,0.13995073407554073,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0019104256646341369,-0.05960679864029339,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09253354734573213,0.05928888373847035,0.12091304646762904,-0.024713823620489864,0.2097809183119541,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.009255211595810714,-0.015329736878979,0.7228579124835106,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021312832010322004,0.062299887004846434,0.7328032341194124,-0.14451464493417246,0.10188898091352844,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10522396425101829,-0.09998827937018268,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1318731435255892,0.08226686443886339,0.11125637190302612,-0.03081458079789401,0.2945608678490724,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.004075496692750884,0.07068998275869703,0.7037076335985827,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04256211998057792,0.05557512612855259,0.44509366875365375,-0.06734106960268232,0.15246530956383816,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07842563890689007,-0.05688379292987726,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08226106068157926,0.04176960280608499,0.05093953962980535,-0.0003408674795183225,0.16486298884267686,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.010358947256213778,0.013960244206221276,0.5306536293719093,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029553837067733717,0.04831509464649942,0.5417643897517253,-0.12509987315561766,0.06599219902015023,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11677711115075096,0.009237778046731197,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029350124171495226,0.045743585761044536,0.5221980903849454,-0.06111059680798113,0.11981084515097158,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.13495320847916925,0.01913134433415208,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011279410375934674,0.056478135182812764,0.8420034517065811,-0.1229683552457631,0.10040953449389375,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.16666696267420253,0.010139588049369853,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07351721227991885,0.07041648086211938,0.29832178862237174,-0.0657356582952051,0.21277008285504279,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15730616284697546,0.15938527530746538,0.8855940007795015,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03773438225510257,0.0614565527927254,0.5402404025906158,-0.15926845051954558,0.08379968600934046,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2095611859885116,0.09152315032484307,0.9481163084809376,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00732690614823233,0.0410674692806092,0.8586653591969056,-0.08854032258945307,0.0738865102929884,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.16755633186629945,0.10717526810786077,0.9839047884462332,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01942865060369823,0.06092833592499184,0.750308936974664,-0.13991813790900293,0.10106083670160645,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.143727835034077,0.04929479722369,0.9646550643928868,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013887857360475587,0.05286234606427957,0.7931659770314565,-0.11842635949324148,0.09065064477229032,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12684321945407792,0.011271076909383152,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020701529398312435,0.04606228921329607,0.6538407524914341,-0.11179250582431029,0.07038944702768542,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.18020121811872233,0.10257904594027305,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0006579338097053133,0.04476014075377647,0.9882937784271687,-0.08917383251692121,0.08785796489751058,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.17790978381756,0.11777521674418262,0.9990191441902606,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010620972345686094,0.03786619915547683,0.7795302027844466,-0.08550368255232589,0.0642617378609537,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0421880131622582,-0.06552504807543086,0.9705004312583027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03839967308774417,0.03891959204574725,0.3255706351776855,-0.038566185580983764,0.1153655317564721,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0472511787244937,-0.025571364104744074,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010510823440953367,0.03817158868762904,0.7834597036936217,-0.06497581312603748,0.08599746000794423,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08399668663547025,0.06105435115705697,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10570873995905425,0.08039375993652924,0.19076062608528616,-0.05327480637024673,0.2646922862883552,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12467320702590319,-0.0145861226504242,0.8119345039490624,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03587642335359045,0.055618122525327066,0.5199819980316411,-0.07411179421746368,0.14586464092464457,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20628447580171302,0.15600122614720832,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051617198059971454,0.06850417905587998,0.45245812418993503,-0.08385397947022097,0.18708837559016386,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.020407255621214367,-0.13723486799403006,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017650360929427227,0.03898384997270989,0.6514424049568779,-0.059442571695243994,0.09474329355409844,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04813471642764526,-0.0006634934667808174,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011214205159931594,0.03975800000137615,0.7783250489963313,-0.06740965619658973,0.0898380665164529,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.06962886667030342,-0.10931543604493507,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036793136083430336,0.03949027971811779,0.35314204608235855,-0.04130129214183424,0.11488756430869491,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07271554204943938,0.020420436523007485,0.9092831415853414,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003437587629894139,0.03667587998846278,0.9925353652441629,-0.07218502294739597,0.07287254047337478,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06255193690848322,-0.029614278996706173,0.9994603233931454,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026572378324094433,0.04397741097621736,0.5466987814627999,-0.06039562467638828,0.11354038132457714,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.006394684750985092,-0.05473548336928266,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003795882383966011,0.03183173459488839,0.9052545552446587,-0.06674507216814682,0.059153307400214794,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.01758294457765675,0.02612648431658222,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03102307442571409,0.03674515100001356,0.39999748474535746,-0.04164269492006559,0.10368884377149376,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.002739465560412316,0.022747911349016665,0.9216778037470674,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01035442219301468,0.03545936638120314,0.7707253980436903,-0.059768629923523095,0.08047747430955245,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0027978557405014676,0.02685987158340318,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017182736200030232,0.04396512693237351,0.6965370476698387,-0.06976097435716955,0.10412644675723001,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0932190160770834,0.026751642984249403,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03151988370640808,0.03448954865936339,0.3623885185074228,-0.03668529492302304,0.0997250623358392,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,3.8899086804058775e-05,-0.013808600856530557,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011493934206882092,0.05927122542773844,0.8465271013655479,-0.10571851637665647,0.12870638479042065,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04284249073785966,-0.04587701711069448,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020567399898517972,0.05610468706071736,0.7144948077082645,-0.09038302861298093,0.13151782841001688,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14149624481988773,0.06487366986847232,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028845325771819065,0.04920287982868692,0.5586773973279947,-0.06845635947035505,0.12614701101399317,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06048532593417861,-0.028968393081141873,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01327576236443573,0.04829028472591817,0.7837981270654244,-0.10877273532650905,0.0822212105976376,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1298104277922723,0.012790371679023504,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05916290457530349,0.052639262354176666,0.26302219450962283,-0.044934435962477204,0.16326024511308418,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04175989673674668,-0.00556970304588506,0.8670850705749964,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013651390943243327,0.04204995170861938,0.7459470700155892,-0.09680772609773981,0.06950494421125315,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.016603690482412888,-0.021759180272527493,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013131572725131577,0.052223421026730464,0.8018458590078554,-0.0901434163142259,0.11640656176448905,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09313476650550058,-0.02448725342283288,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013530100903551008,0.04188159003233686,0.747148968854285,-0.06929328880365612,0.09635349061075812,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.061689246771232706,0.025889255231153853,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05311465040943431,0.061012974251939335,0.3855356584692172,-0.06754221433143398,0.1737715151503026,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05603338264065571,-0.03249698264829012,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0032430497472019145,0.03913784182978694,0.9340829041047987,-0.07415441113393191,0.08064051062833573,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09715624716907476,0.04200256134843722,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04236425774923798,0.045560278401097346,0.354095918140621,-0.13246247728363109,0.04773396178515514,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20623937001182271,0.03349242128985401,0.9094475823584263,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00976102485733223,0.049012535230825514,0.8424399986749472,-0.0871642423740843,0.10668629208874875,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05953328343655221,-0.03539560582477061,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04161052564467899,0.04800902401176823,0.38762036932576016,-0.053330237161108913,0.1365512884504669,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04751943365220726,0.029065612275265246,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004017538413140576,0.04227125625157977,0.9244214780465295,-0.07957643992518518,0.08761151675146633,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.104210090772598,0.0658606955318595,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01649049878191307,0.039952543663858905,0.6804381755513986,-0.06251808449085919,0.09549908205468532,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.04084332744142723,-0.04828816124484183,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011429239897993777,0.04703069148341543,0.8083586626970675,-0.10443529066929497,0.0815768108733074,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04592160398283654,-0.06232601399189944,0.974516576191754,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02161472519746724,0.053512260974306454,0.6869052576296464,-0.12743847356439283,0.08420902316945836,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14407606444344967,0.08718320613779777,0.9631430579652833,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04016444942515399,0.0718662421725923,0.5771641860203278,-0.18228431110321888,0.10195541225291091,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.33898913720574825,0.08851474618882631,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002965445043088803,0.04987945109607461,0.9526791770329794,-0.10160509108618486,0.09567420100000724,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1063963910750876,0.09293143362368585,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024613191439886845,0.0678073822142613,0.7171782145787875,-0.1587064108668751,0.1094800279871014,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.316404479157842,0.10607963859654701,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0005194344188526497,0.05530918205751359,0.9925205650423697,-0.10885783460076669,0.10989670343847198,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10377870647318183,0.11495266233873666,0.9994603233931454,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0025156183835080568,0.07045612302994772,0.971570134451007,-0.14184688375482649,0.13681564698781037,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.373175646763637,0.16552731200829693,0.9975397208522654,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005180044473250151,0.030678289192227908,0.8661651060580093,-0.05548813692474535,0.06584822587124566,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06158861116027444,0.025097963224829174,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026661251427205067,0.03639741693479523,0.4651215842032911,-0.04531685267053095,0.09863935552494107,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09625542526984324,0.0703867477616072,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02729355305359115,0.038232513433872656,0.4765227097719874,-0.04831356590189192,0.10290067200907421,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05460420714763977,0.01856677758139349,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0055401336234476165,0.04163939201286016,0.8943502644444603,-0.07680429478028598,0.08788456202718122,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.033822421202113824,0.004349343243818076,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036518951401919776,0.07221669064853226,0.6138958996194916,-0.17933184624020282,0.10629394343636328,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09249917128522461,-0.02462430480126577,0.9556150025445134,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06462635317606075,0.057222555913460524,0.26072313346593506,-0.048534728931942245,0.17778743528406374,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06570288107811256,0.06667775100412221,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007918814762865212,0.036837653989763075,0.8301164431973673,-0.06492988486715606,0.08076751439288649,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12182105899280732,0.07703131141412284,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013950879358090024,0.04289522954954435,0.7455056767313952,-0.09877880281608076,0.0708770440999007,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05437186805707369,-0.010410922505364371,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041017319882733654,0.04337438031741815,0.34600026938386574,-0.04475815333985481,0.12679279310532213,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11805993870409139,0.10634260798256603,0.9073781709238445,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006946747032003947,0.05095289044891022,0.8917567499605119,-0.0938156905712576,0.10770918463526549,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07196652063609177,-0.029459171598424275,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05602323615449274,0.048350811410540775,0.24861616583196333,-0.03959343200502444,0.15163990431400992,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12691555953030956,0.08975564999818031,0.8577318021260126,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002999214068663004,0.04980515937416233,0.9520696590556011,-0.10149194371648347,0.09549351557915746,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05680129365338101,-0.02646827570011452,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0871815350670908,0.06479414579466383,0.18069780001454275,-0.21531589634023196,0.040952826206050355,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20535959230905168,-0.006617245979924941,0.8014130815101496,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09092366194191437,0.06498214221441469,0.16402664398451075,-0.03758247367705661,0.21942979756088535,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.028518571085031082,-0.035937436749808246,0.7824698350312412,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03559183082278352,0.060688423903613016,0.5585330896664668,-0.08442321587922125,0.15560687752478827,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12106250533290777,0.1221571629682564,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07014772940827013,0.08854282721868774,0.42959681482884804,-0.10495109274363804,0.2452465515601783,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14638053360675415,-0.04209374749140571,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05716704448971732,0.07025697188963573,0.41724774660191366,-0.19610447637735093,0.08177038739791628,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1703142605892283,0.05530319740095946,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06222055441040693,0.060465300918104814,0.3052926354775653,-0.057353253027111625,0.18179436184792547,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.021159725242258058,-0.02777049100989552,0.8935888423380949,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021674909808074037,0.04387627911614635,0.6221026512434757,-0.06509309879267339,0.10844291840882148,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11724485574240735,0.08815729621076193,0.9582992440631078,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0012934572189183169,0.04644112697973274,0.9778213812935881,-0.09313360835249451,0.09054669391465789,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.22390315777475017,0.09902046338332254,0.9983210449785855,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04095424490248761,0.0380228491149904,0.2833444106782757,-0.03423825011973328,0.1161467399247085,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.009525051232030053,-0.028035321006461743,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10208189985612817,0.05151843480312036,0.04955589177786272,0.000201063920585276,0.20396273579167107,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1546939280013098,0.20613419338853045,0.5240813480471289,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053944263889884644,0.0814888863203979,0.5091022029627972,-0.10720496142151244,0.21509348920128174,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07203499373956179,-0.0425455116834586,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0050006094017476565,0.03923692866200233,0.8987752598032897,-0.07259280171224723,0.08259402051574254,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10599205149806644,0.08001309727116235,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03097459077674873,0.03393755444472155,0.36301876804973043,-0.09808816729842545,0.03613898574492799,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07050941782428813,-0.024490102291394367,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0913405685488855,0.051439028635987524,0.07801791015875861,-0.010383236865119883,0.1930643739628909,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.026931797280247218,0.04918910968020761,0.6337247675321748,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026125303262617038,0.035910419085110376,0.4681622222857237,-0.09714033951455547,0.04488973298932139,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07840943861735601,-0.02616877799484889,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07135513289275278,0.05092259270725073,0.16341804388949152,-0.02934738908498513,0.17205765487049068,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04930067107132913,0.056057319167276826,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0097715691356163,0.03737057387100612,0.7941197709115091,-0.06413101194859121,0.08367415021982381,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04677376569873683,-0.03002971003135107,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021897961602533822,0.036478665488518025,0.5493086179380822,-0.05024081644819525,0.0940367396532629,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0348109895364136,-0.01409243938608555,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008725512076804054,0.06797137119592117,0.8980454901000967,-0.12569200552809998,0.14314302968170808,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0548183970291082,-0.06088832290457673,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-9.952492291220543e-05,0.048659073042018525,0.9983710436509459,-0.09632579919375296,0.09612674934792854,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12986463031180626,0.00833704746014546,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021382947176245455,0.036737685665558906,0.5615006998148554,-0.05126805901693291,0.09403395336942383,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0957188478807265,0.06577304569525308,0.9509691818071948,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012821751421363931,0.06650185937689988,0.8474009520714035,-0.11868971724957711,0.14433322009230498,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.165844769099634,0.08786086780204189,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007518481552271457,0.05051139736901692,0.8818946668618299,-0.1074078397576208,0.09237087665307789,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0797889302657172,0.029282695130189645,0.9868170095220195,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022728464590122528,0.06175732025134451,0.7134240296715584,-0.14485731878359126,0.0994003896033462,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2071326390388155,0.012235905848798958,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010538737311323565,0.05719282217718024,0.854078647221397,-0.10256354452607146,0.1236410191487186,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07515448009326908,0.01052721929094612,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041342644454007434,0.05918354552521497,0.48602631595428214,-0.0756964137934096,0.15838170270142446,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.354493931740326,0.25689786642612306,0.9400644974323602,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058159255157754344,0.06080202803066261,0.34049936254440005,-0.06208045060995712,0.1783989609254658,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2488401366160011,0.1873112226088845,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06007003846987029,0.060837847721646764,0.325210069277482,-0.06024050291375933,0.18038057985349992,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06311509269561688,0.10346538979294292,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0681505714555852,0.06141418611639708,0.26909188651220317,-0.05329971413151845,0.18960085704268886,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05125450884855854,0.02833160409970641,0.870012817074135,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04670051683753019,0.051186828296659395,0.3631967439581705,-0.05452454707758903,0.14792558075264942,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.19594237222228084,0.1522530463696664,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12386204272569075,0.1491507047208504,0.40774047260273383,-0.4188166261754038,0.1710925407240223,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.39676914210931485,-0.5006077092506059,0.9246299615143487,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04246132761972055,0.046326629075270374,0.3609935149020487,-0.0491523969489945,0.1340750521884356,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0025045885876145532,-0.021822036360011503,0.9134053709502656,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04289518021068969,0.044265173208330066,0.3342402938479174,-0.04464189009298959,0.13043225051436896,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.010942534652255791,-0.021576180434742263,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04165678252238334,0.05464147622681688,0.44716201367121877,-0.14971362268094773,0.06640005763618106,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.26390495412197335,0.16670880213130693,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04725887397489545,0.04329839112917502,0.27699620147085324,-0.03836632600958205,0.13288407395937296,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.030064497260162068,0.05073686735989715,0.8725380346331878,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03784902836923611,0.0534268412315806,0.47989247938368973,-0.14350385400340465,0.06780579726493244,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1967198148657398,0.08251369129199665,0.9385036958235352,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029313038486261392,0.05740553623273078,0.6104374138123985,-0.14283597529653258,0.08420989832400978,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2345543080770813,0.1343739546079693,0.9549530254352627,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05943638837327881,0.03825579154116353,0.12259021989050285,-0.016216764454134842,0.13508954120069247,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.022020899381726643,-0.025067422292879074,0.7228579124835106,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028359868077973867,0.03630103660311235,0.43601844263802003,-0.043427638056195865,0.10014737421214359,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0034985812490597994,-0.005656040441475124,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03467567561878269,0.05440772021594483,0.5249813376291264,-0.14227024905896535,0.07291889782139999,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05412865816992546,-0.06799507288140327,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04643212434774554,0.05418230410226488,0.3929739379922784,-0.06071667502762287,0.15358092372311394,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2285483837997622,0.13760999259713005,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025426867457042986,0.07862950976472058,0.7469074860240908,-0.18092150184656575,0.1300677669324798,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15208043218910472,0.025268145762379204,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024611772526792555,0.05743445593429853,0.6689510184562374,-0.13819189980455343,0.08896835475096833,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2244870769889897,0.10326879779329443,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09367082433257917,0.06550726070172443,0.15503028874644154,-0.03587376500993317,0.2232154136750915,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.17511097460218708,0.20514938784767547,0.7738863562892694,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006450553307672254,0.066986883608382,0.9234274280750486,-0.1260200802591208,0.13892118687446528,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.21706476292169838,0.06958607236442778,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01173192303885542,0.03827156708595426,0.7596592235779752,-0.06395242688716497,0.08741627296487582,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04027835915040934,-0.01604015720324008,0.9673425418314568,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029607836962642443,0.08089998994254237,0.7149481243273923,-0.13037680997045928,0.18959248389574415,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.40361606239853565,0.10569197198439001,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057106131377077735,0.056641218581688677,0.3151450245376932,-0.05490532082567304,0.1691175835798285,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05385400771375872,-0.05925930531201731,0.9025176929330414,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01488717033864318,0.032286471220307464,0.6454661178943623,-0.07873562943691031,0.04896128875962396,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.027640510943942796,-0.05685934650219696,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058136145814518314,0.048000605305940906,0.22793660693446643,-0.15306026011787285,0.036787968488836226,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.05169983317737407,-0.1730334060842785,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07588036181400261,0.04488018120631777,0.09317857343585023,-0.012872924183757434,0.16463364781176265,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.13920802710080915,0.1620586205489732,0.6699741992153797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08316407324984888,0.05723484921083502,0.14851832268269102,-0.19634946610055404,0.030021319600856286,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.11886534429369115,-0.2156513824081857,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10602213302599739,0.05489803124217659,0.055531677473997496,-0.0025420602679677856,0.21458632631996255,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1463964964669677,0.17029917089394994,0.5506521745982841,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04546680894298109,0.03800238356613444,0.23361431909182417,-0.12061883209851401,0.029685214212551825,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.053567980107351136,-0.1303740723450046,0.8449482942840995,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05905576352003766,0.03843613270789347,0.12674769643289893,-0.01695402492509715,0.13506555196517248,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12476506772610424,0.10847797932184491,0.7263564310373228,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030831993381835388,0.03984575529242691,0.44040172458188354,-0.10962939615987281,0.047965409396202044,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.008097107731079023,-0.08476861651917073,0.9320838159679753,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0717332011429812,0.03831939472791736,0.06335678989023022,-0.004045730851819973,0.1475121331377824,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07803290663727652,0.07968982580049919,0.583441065137642,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00366134795012981,0.04237394224891168,0.9312710400426754,-0.08013569818881974,0.08745839408907935,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.023526976291379596,-0.08334359896911732,0.9918526261485133,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0750111385839325,0.032110891470530506,0.02095289289081778,0.011509899111979527,0.13851237805588548,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.01647361927248849,0.05617607186932967,0.3339840637897822,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017284778543961887,0.03318713009488462,0.6033337185129146,-0.08291434530563825,0.04834478821771447,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.032110271287631255,-0.1145381197388456,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07505853849636202,0.05780153252226518,0.19629384588773685,-0.03924750504374899,0.18936458203647302,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12867672286545664,0.2100182624407972,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04280828688819837,0.054219003762704054,0.43116852261191974,-0.15002966207256374,0.06441308829616701,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.06808170968335245,-0.05899566007184357,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01968999034512939,0.04257839657514281,0.6445042032161847,-0.06451137664996938,0.10389135734022815,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08290916645800082,0.021949542473636063,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.068332972377316,0.047117249282508544,0.14928419884300004,-0.16151019645700765,0.024844251702375628,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.047077745542513254,-0.15062866242841724,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09207297485301517,0.04473383100541265,0.04147644268033025,0.0036091052722042882,0.18053684443382606,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07741791534621045,0.08788900673127428,0.49032550277088105,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03225993739791646,0.036411641633105396,0.3771929289263768,-0.039746296905255905,0.10426617170108882,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.00582198513539236,0.02482509335617088,0.9170591775765864,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013713088641677031,0.03715883746610039,0.7126719945416333,-0.05977077083322267,0.08719694811657673,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.034256504042849266,-0.02314166870797943,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03429908103038135,0.04758201046164715,0.47224438309997785,-0.1283953985883974,0.059797236527634696,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.01963135444888077,-0.09823792547600065,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059661228708279446,0.038627961442333755,0.12478886734850868,-0.016727912717898363,0.13605037013445725,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1721480330175915,0.13700268943626576,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04078214057639396,0.04102014315870706,0.3204786120633388,-0.0397585868811717,0.12132286803395961,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02930427311329652,0.1258473705631422,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0504613643958177,0.04080453552909912,0.21663814906741605,-0.029656029694362103,0.1305787584859975,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.021330624810287496,0.039289834419807226,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046753969235469636,0.029906252635720235,0.11843325853922053,-0.011965263739693102,0.10547320221063237,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.022809919830074413,0.06202986984453035,0.7204222518350135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029795794889692768,0.047163414960889764,0.5277573791052036,-0.06280689875855695,0.12239848853794248,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.038869979809127445,0.08654218172414196,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03907871923717616,0.032633016397405984,0.2315190180649848,-0.024994359923296204,0.10315179839764851,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.036985025895706264,0.0928258452699144,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03408588222803619,0.03759848910571504,0.36495085472636735,-0.03973662132012291,0.1079083857761953,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.006475411297342063,0.09301895803919631,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02611322786614636,0.04179694090672939,0.5323345527472061,-0.05595269796703337,0.1081791536993261,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.025915490281553325,0.05716252431615692,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03855989015809189,0.028479323086908127,0.1761966730515267,-0.0173576474780913,0.09447742779427509,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02122556971757607,0.12433904394599798,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026780706041330735,0.025695268869847368,0.2976679467793122,-0.02367049884569965,0.07723191092836112,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.016629787734349952,0.0491305519075781,0.8847007730863069,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05877245714428486,0.04293471710795413,0.17148694045712173,-0.0255274278093202,0.14307234209788994,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02581930498338797,0.07675892041712659,0.7848027568782422,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038455845541464403,0.027670182287801128,0.1650443430279684,-0.015872989970410367,0.09278468105333917,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02414983968437298,0.11358725587710339,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05414674521054026,0.04403052567827962,0.21921241736540584,-0.03230469779752557,0.1405981882186061,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03307243672775588,0.06969595580640729,0.8337844604918982,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04823394521554146,0.03042736919892864,0.11338018260198131,-0.011508470612216527,0.10797636104329944,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015531990406579276,0.09516581296615506,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030485548402100833,0.025200878305514072,0.22681186291360309,-0.018994948617199747,0.07996604542140141,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005215321714996858,0.05187849010919356,0.842579263271115,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05185567651728968,0.06437731713740011,0.4208137998955963,-0.07454553895267704,0.1782568919872564,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03209293575170784,0.07746948128121746,0.9279699506567693,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018542622438302892,0.047660025223463215,0.6973528239498132,-0.11212038220603954,0.07503513732943376,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.029641297541224534,0.028316740233801055,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02171544557016466,0.0226501995975194,0.3380335926772957,-0.022756938292202468,0.06618782943253179,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0017251255368987849,-0.0038063972288571186,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028906436632456053,0.02879193180160831,0.31574526314681167,-0.027624890506950342,0.08543776377186245,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01433799672151846,0.10007405060541606,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04232108534670267,0.02734517907006602,0.12216698428105793,-0.011369624757341115,0.09601179545074645,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005794794143369481,0.050952282896347026,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017821818380041668,0.02510879109898632,0.47808033241574344,-0.03147787062563047,0.0671215073857138,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0030527592794266406,0.0682963604880067,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07326673295319926,0.03854263977984341,0.057732299383226215,-0.002409556961078571,0.14894302286747707,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.018864670535838058,0.06537676043312245,0.5623055122749077,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0027371777074282583,0.0439091677473807,0.9503124854901259,-0.08347598587778116,0.08895034129263768,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0009289227208804013,0.05685499533960826,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035055875769939716,0.028331474575605687,0.21638337089784468,-0.020571369689355037,0.09068312122923447,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.06488831735778242,-0.006780394278544504,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0010596789233825242,0.04827522272424823,0.9824936269144602,-0.09584534413532003,0.093725986288555,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03270515951971402,0.04513358514175852,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0234783322802414,0.02563406442120004,0.3600407110462832,-0.026852701138868392,0.07380936569935119,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012190274125947021,0.03966652022562567,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030053308042486824,0.026819678188791305,0.26286509613321374,-0.0226056108487934,0.08271222693376705,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.05241738779607277,0.13600215043223446,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03202248421922137,0.024476772829744687,0.19121829085897601,-0.01603627271621766,0.08008124115466039,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.04334776706388136,0.023466349942992962,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037402028682787684,0.027069811216963256,0.16751934397710055,-0.015748012240226754,0.09055206960580212,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.06952218289552366,0.18515343025529302,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036540424247114574,0.027346603215415325,0.18193018706662392,-0.017153082085650175,0.09023393057987933,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.013794713465082735,0.05098351315941558,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04521860654692804,0.02554871322298358,0.07719029928949302,-0.004944844629303363,0.09538205772315944,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.05441051745129947,0.11634264999697302,0.6310366588671427,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012372214526673354,0.02432642770986101,0.6112028203503148,-0.035391348282351326,0.060135777335698026,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.023636082647110642,0.04697298940971088,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045044701282199354,0.042184434412679335,0.2859862698139824,-0.037782046099884864,0.12787144866428357,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012068551909294461,0.006788604544584829,0.8775950049080478,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028929237849644015,0.04359312776516063,0.5071579771246291,-0.05666339913293511,0.11452187483222315,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.00909515138309549,0.030326867717963876,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035732838677784706,0.026328180059037618,0.1751631782499806,-0.015961051477217388,0.0874267288327868,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.010132689044150656,0.03595696749918871,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050923538556777274,0.038855469626592726,0.19043729156826564,-0.025366975040975952,0.1272140521545305,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0006765730501524214,0.050325804713425494,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014441264361288614,0.028560841661041166,0.6132784230819956,-0.0416363303774887,0.07051885910006593,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03500152870750651,0.07925449825052158,0.9552990821084932,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07518310918394641,0.03323754173558073,0.024011282907760174,0.009923078766021165,0.14044313960187166,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0043143171456962665,0.10122811419818191,0.36513709525249094,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00488716591639027,0.02451265840824159,0.8420302013731502,-0.0530163821524269,0.04324205031964636,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.045256575639069395,0.11927487897252251,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022433431716214664,0.023182440343108148,0.33354139893217616,-0.023083976700709042,0.06795084013313837,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012776128816012856,0.035407976709038044,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019588485998473265,0.019779222395319766,0.3223505034979508,-0.019246896757276234,0.058423868754222764,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03001524860505864,0.05707846219653643,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04063721553467004,0.02480235743323159,0.10179014314389674,-0.008060808326590334,0.08933523939593041,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012754202738475657,0.04342526035287907,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014316092373165725,0.022252041142068184,0.5202059177465412,-0.02937452991607986,0.05800671466241131,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.024666117918752235,0.03524156114429614,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012471469661977834,0.023255747978709617,0.5919433132649468,-0.033189874144851576,0.05813281346880724,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015228699875200204,0.02122650137218486,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03220309741727203,0.022332730822097337,0.14976958630155943,-0.011645954487948376,0.07605214932249243,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.032169073938519255,0.07762232310773491,0.7665190045530488,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031117835316517087,0.01763989748558501,0.07816889106172276,-0.0035171041635595826,0.06575277479659375,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0017568417340465537,0.04424501240847866,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007514906492909486,0.020431709820034873,0.7131318078959883,-0.03260159836034575,0.04763141134616472,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015390854613658057,0.01399065320033396,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015461404656600541,0.023215059212217233,0.5056311502769424,-0.030120049062084403,0.06104285837528549,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015270190588100224,0.024038423366739038,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004183268914724418,0.017663618598896612,0.8128599473213266,-0.03049824562762904,0.038864783457077876,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015180792688249052,0.00666211379891847,0.9764652333287971,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017074634764213014,0.018334047984546995,0.3520236362724618,-0.018923229899598982,0.05307249942802501,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02441671090293644,0.023886222217186896,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009956092341902874,0.02288358209430479,0.6636448632237162,-0.03497452483267463,0.05488670951648038,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0165388493559495,0.04332701303458293,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012978901459980636,0.025027000425727586,0.6042104921669171,-0.06211799911183873,0.03616019619187746,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.07575415870438781,-0.11529993629922242,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01321479344928078,0.027365910037890767,0.6293267893389147,-0.04051662073575669,0.06694620763431824,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.07032533270089215,0.16943524839537275,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048713696022855656,0.048529826520834915,0.3158359125266894,-0.046571869321346444,0.14399926136705776,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.006945138531326342,0.04520973876103865,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07561688378192175,0.03294657947866186,0.022027614184774814,0.01092814127355532,0.14030562629028817,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02229669553090215,0.1731751149527997,0.34624792356186623,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0385701629939762,0.027630562035717423,0.16319097646851735,-0.015680880397268282,0.09282120638522068,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.052949889372230934,0.10057088346175604,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017606859285374508,0.0361259788818341,0.6261497721450546,-0.05332445385027869,0.0885381724210277,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04806089754886663,0.06570007408011605,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022590662941111485,0.030248609072018682,0.45542130810546066,-0.036800767503537744,0.08198209338576071,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02833374528160019,0.06469783783965544,0.934143241276782,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0035364874739538836,0.036378551069382974,0.9225853404864686,-0.06789073684470104,0.0749637117926088,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.039460127520254865,0.07741765947927778,0.9911330941645131,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031540348790325835,0.02829793932122099,0.26542200991945075,-0.024021052096628734,0.0871017496772804,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03343132390587763,0.060770133790723664,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020310061964672138,0.02670850996205587,0.4472575654314507,-0.03213058441066883,0.0727507083400131,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.017921930668000376,0.03764767866472188,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00531163752134042,0.02125187590039512,0.8027109544741273,-0.036415216971423886,0.04703849201410473,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02237216384652713,0.059909005244084955,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027867860719132238,0.027429055309305044,0.30999018364042813,-0.025987535629388537,0.08172325706765302,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.02047312153210571,-0.011911698529598475,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010865871292452284,0.030941450154064055,0.7255651798047829,-0.04988591336998999,0.07161765595489455,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0051326792215038485,-0.002224035630814064,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05878181069955189,0.03948062290368427,0.13698120877297,-0.01873615594522335,0.13629977734432713,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.009985205941950119,0.07985356736022242,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038403688534693475,0.0373394919322024,0.3040785136725159,-0.034910288734474965,0.11171766580386192,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014950890720649094,0.06665578861535752,0.891349793771208,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05138502694350686,0.03085003146385356,0.09624382067254146,-0.009187262299226992,0.11195731618624072,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,6.777025258592272e-06,0.10749934561685083,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04869042478757318,0.034898259234571974,0.16340579926566098,-0.019830330366313223,0.11721117994145959,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010672757301726071,0.05815381985465116,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0355485352028829,0.030102615123506617,0.23804880119766197,-0.02355624439386289,0.09465331479962868,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.046671504083011586,0.17186766904278714,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0687605010570597,0.031501594908298104,0.029393139328341707,0.006908903899741407,0.130612098214378,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0060661484785160475,0.10565676200148535,0.4079068880915672,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0066966715061022525,0.033442598855723565,0.8413495579244757,-0.07235931996372472,0.058965976951520206,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02371668073885613,0.06785389351851191,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009830707931277433,0.022933776988984387,0.6683085248309565,-0.035198464075654246,0.05485987993820911,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04697150974715245,0.056237232274738085,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025333262315693997,0.024188726798960534,0.29532392357791587,-0.022159932555008654,0.07282645718639665,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03736292525309662,0.0784864992250468,0.8830041858734644,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0010192091487160845,0.024651486626573033,0.9670331541190876,-0.049421006727357775,0.04738258842992561,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0061915482708906865,0.022339621013466034,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056574822498722574,0.04128305089468198,0.1710083043353835,-0.02448210940570998,0.13763175440315512,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010388077862988905,0.10038691824311118,0.7845446469755442,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0076103543201744535,0.02457780490904997,0.7569266170021037,-0.0558674820202477,0.04064677337989879,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.006162484824106823,0.01142340425855952,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029514634335240424,0.03199688129254565,0.35663410779395366,-0.03330942958146454,0.09233869825194538,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03129419821101731,0.05430206008389061,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02114925160755335,0.023336702804669266,0.3651148733689282,-0.02467104241426591,0.0669695456293726,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02985913981184539,0.037839298698585246,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0166132153667274,0.022007120105489053,0.4505681041017341,-0.02659651834103704,0.05982294907449184,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03835039116870682,0.05219524001296453,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015926507930137737,0.02459698582648916,0.9483921291415001,-0.049887439137953106,0.04670213755192556,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0046109065928881645,0.0007726848178644779,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033418982458348423,0.022245868527339875,0.8806310061357145,-0.04033660446404677,0.047020400955716454,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0011759687947885476,0.001133110832504853,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016867467019077063,0.025493093779254034,0.5084196750407851,-0.03318677853002059,0.06692171256817472,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014936041187032272,0.055375521877631506,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013781730276972968,0.019216022523695118,0.4734959308595478,-0.051511301987910735,0.023947841433964803,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.009063438076377077,-0.029681619313431037,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017866432361277693,0.0228506910384462,0.43455775438789335,-0.026999605088274255,0.06273246981082964,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026014432990532237,0.04201544236986266,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020954689566410997,0.019013959452322586,0.2708200004135401,-0.05828752188281061,0.01637814274998862,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0029050947910483566,-0.03335737469331345,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03253231803872379,0.024031931350839426,0.17627600797578677,-0.014653017851456791,0.07971765392890437,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005745115586619276,0.05935420783369283,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05141114739216326,0.0236178652538856,0.029837980728699157,0.005038806828087418,0.09778348795623909,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02188875227542453,0.09370651940998075,0.4119198104772415,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03269005739107528,0.03782569992266545,0.38776564857007434,-0.04157856172554032,0.10695867650769088,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005539886240935238,-0.018248772972000022,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02996718985798304,0.029524137642404802,0.31046217655969616,-0.028001781973160864,0.08793616168912695,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02092376949527211,0.08782597702363018,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020380588385193875,0.02896104169519676,0.4818443271298214,-0.036482776450843385,0.07724395322123113,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.022109075322666184,0.061744428764762355,0.9400049812623549,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026760233259585736,0.024541460019324328,0.275917478820538,-0.021425533308310506,0.07494599982748198,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.00013586429422758948,0.034702125551868995,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04094481863043917,0.03226786612041873,0.20490763040675888,-0.022411308645538308,0.10430094590641664,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.022771179987463263,0.05803452488513924,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026296111624761385,0.02275816532961316,0.24830683952061028,-0.018388256836725167,0.07098048008624794,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.028189946353845332,0.05326018788741632,0.8577283255503066,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043498836635244405,0.02807376306319153,0.12173727318770472,-0.011622406867798765,0.09862008013828757,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014356406457573932,0.09235303970961375,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03942397316501326,0.025672854125818347,0.12509254659175448,-0.010983221641825844,0.08983116797185237,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.027238405784474045,0.09083074009595853,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04079627122294132,0.029793100539916753,0.17134952954637694,-0.01770079402174566,0.09929333646762831,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014865688043753631,0.07609698789892487,0.7848027568782422,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008670764287181616,0.02245108472968658,0.6994637052669835,-0.05275219738565634,0.03541066881129311,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.004177636714679587,0.1018559587341281,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027310505123277443,0.024322836378746413,0.2619025856494853,-0.020446006310538924,0.0750670165570938,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.002605258984180547,0.09982764457746206,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04360683374066015,0.03159267851108421,0.16795114408065895,-0.01842360091119019,0.10563726839251049,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02202799818233869,0.08293695629945486,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026644012020397522,0.02415328535279063,0.27036286103039175,-0.020779595578373184,0.07406761961916823,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.021201641382363013,0.06867357706888459,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008129561410839271,0.022563903819759472,0.7187412511299901,-0.03617338558022269,0.05243250840190124,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.008255403457942047,0.06114717234751716,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03028362135699115,0.02310150739308245,0.19033424817017155,-0.01507487979709983,0.07564212251108213,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04093239513508484,0.07613957726499844,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002182028158268705,0.01892063924302084,0.9082211920402845,-0.039331631529938044,0.03496757521340063,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013715160137181293,0.017251265707452522,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02161732694906948,0.02533917044125319,0.39389240976451967,-0.028134698845033165,0.07136935274317212,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.007076872300142219,0.03678676018307436,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0008824297382707973,0.0376689800983275,0.9813173881280871,-0.07484333835737875,0.07307847888083716,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.03315351652872148,0.008863209569760088,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04162415260597045,0.026816258603304867,0.1210779917660887,-0.011028052122913613,0.09427635733485451,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010008009499574304,0.07785022796656588,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025386039858790337,0.03425266871996295,0.4588629940293609,-0.041867134889899994,0.09263921460748067,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.029028951851795597,0.07357361824654753,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024941811613322984,0.025968540993450816,0.3371623464107242,-0.026045947608579922,0.07592957083522589,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013292296258546268,0.046511554417866426,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01218266503548332,0.036406896207154,0.7380105638339685,-0.05930021335554114,0.08366554342650778,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.02516495852715249,0.04710023294539255,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021296532432212995,0.01803274932725061,0.23801699027133572,-0.05670281424984256,0.014109749385416571,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0026503619082184275,-0.04927772967476288,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00042834134421489584,0.021005576816590175,0.9837367874676265,-0.04167160153783129,0.04081491884940149,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0008592348047044475,-0.010741673820419741,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016625003949157276,0.020795461850145684,0.42430545902673256,-0.024205707410056298,0.05745571530837085,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.020367902333799325,0.03820888377884125,0.9293975534641841,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012016142785791472,0.023955544863172955,0.6161093421220581,-0.03501921256285899,0.05905149813444194,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014731615469530947,0.03823647084391798,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06931315281685511,0.03719705949867203,0.0628344005370996,-0.0037211664373302117,0.14234747207104043,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026244865779682137,0.12347804171835625,0.5817074626033015,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013567353015168952,0.032685272067893734,0.6782058520688761,-0.0506083271942218,0.07774303322455971,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02953658623836571,0.08194426633216653,0.9621651627753025,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009493150415640804,0.021398393470375306,0.6574444942533071,-0.05150768385740006,0.03252138302611845,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.004759092979599836,0.021220700867060703,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040727875690638016,0.02595875944983111,0.11712381049690784,-0.010240678024454712,0.09169642940573075,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026299561563344485,0.08985226838502103,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01688746095828236,0.025414686879493806,0.506609684759556,-0.033012837084587715,0.06678775900115244,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015003973958362836,0.06124909074405179,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041020378207891985,0.02891852344248268,0.1565064830989762,-0.01575950444743792,0.09780026086322188,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03139263922390556,0.10763120641889883,0.7769533851405084,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00953760249157201,0.026889207459848283,0.7229238251435455,-0.04325783318486074,0.06233303816800476,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0022896447940366498,0.009035481457260049,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04416712855998399,0.02849171907908903,0.12156292262967781,-0.011774747904660758,0.10010900502462874,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.028707490321306685,0.08964995460344093,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053060600494465156,0.03227227408788898,0.10060449317533224,-0.010304181575945613,0.11642538256487592,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01065305665575915,0.09890695648973509,0.6818291067720451,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044085000841414014,0.0382030639875553,0.2489181239369165,-0.030924551240378746,0.11909455292320678,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04517089704270346,0.10382829820098342,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0594875798881604,0.03428545286552206,0.08317991003577128,-0.007829964673238508,0.1268051244495593,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02694019221494952,0.13330650704838182,0.6475069956953327,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018106142256178542,0.04291774051976497,0.6732452625414457,-0.06616041012817603,0.10237269464053311,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007362035525114893,0.02522833314801792,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059306762756217934,0.041426156513726026,0.15270831391580392,-0.022031148924820443,0.1406446744372563,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0117770200746851,0.10748772453828166,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028356307169393927,0.030412858961167834,0.35147022762715385,-0.03135761862847031,0.08807023296725816,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.024347681014760047,0.09269468710812111,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009669296379103002,0.022924669218850283,0.6733142052238175,-0.035341993037090784,0.054680585795296784,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013785341206827272,0.05543532406361974,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02889745432756458,0.02463746471251374,0.24124200714442948,-0.019476812017109612,0.07727172067223877,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.060419468596204166,0.020029066121317805,0.8487082760058587,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03280260282049918,0.02336865471272696,0.16086241664264578,-0.07868563260383607,0.013080426962837712,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01954102682396147,-0.06767378070236431,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013688698931180994,0.025037810423154533,0.5847489284541812,-0.03547162353827981,0.0628490214006418,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.01270542128373159,0.02196557452694504,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02799733398204259,0.03736829509675697,0.4539783832258013,-0.045373196669139415,0.10136786463322459,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0359228310722054,0.09888323433106459,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012024471996932773,0.02147264325003335,0.5756696636560261,-0.03013584668121841,0.05418479067508396,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.03886119575800559,-0.051368998362982414,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-6.244048124243726e-05,0.01994693411622201,0.9975032763572078,-0.039227115700754586,0.03910223473826971,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0042122813004208505,0.01015149267271335,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021482206380939787,0.02447208944311072,0.380347498355337,-0.026567354990139427,0.069531767752019,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.025471383174590058,0.06890457652143366,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020560409355964537,0.021993825160521965,0.3502081343832081,-0.02262322048046491,0.06374403919239399,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.00905070316594574,0.004603027632528911,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0256932894461187,0.023569611001618817,0.27605248185024284,-0.02058430662705054,0.07197088551928793,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026714603922860226,0.0887483267655218,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008894201477752177,0.019288180047381455,0.6448579819885107,-0.028977047443495392,0.04676545039899974,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0067046474334283,0.024711743941136344,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006702756041002429,0.02178002421533452,0.7583680132804894,-0.036061087750559044,0.0494665998325639,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03294463791826067,0.03802146756237223,0.9669418369722411,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046378414714243,0.03914562241252761,0.2365219460942304,-0.03048179744264542,0.12323862687113141,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03708161558178394,0.10719750968443471,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039316117663553696,0.029077661798390334,0.17678854398430469,-0.01777622413902038,0.09640845946612778,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0004702514881725755,0.0333805754907128,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019762901608012785,0.022933001088062715,0.38911824367770276,-0.025264746961411018,0.0647905501774366,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007928648089984653,0.03884756278938189,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03630889878353341,0.04160642841376971,0.38314681869134626,-0.045382966561525614,0.11800076412859244,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0028399030541244475,0.05035496935255043,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04988370562275687,0.029218209964990572,0.08822424483060423,-0.007484594543419543,0.10725200578893328,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.020106219173651137,0.0942970126312463,0.659371665428829,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008953134165372592,0.03235858653152844,0.7821057318346141,-0.05458111749885375,0.07248738582959893,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.00019216300690882437,0.052494716634130335,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04860677265347097,0.03253542871175297,0.13564674391786297,-0.015274698614191638,0.11248824392113357,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.028772272443916076,0.08702625853899638,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011196670000418822,0.04061819568460859,0.7828952807008402,-0.06855485636054484,0.09094819636138249,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.047718688247740865,-0.014063528603693287,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018725469395062144,0.039604626618323084,0.6364996856822743,-0.059035971519069225,0.09648691030919351,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0182033954303416,-0.0015039531179984534,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06236869628773869,0.037424462497981044,0.09606793932765885,-0.011112115874077864,0.13584950844955523,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015286774912264838,0.1084339796208153,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026277227202305655,0.03372902729519479,0.4362091275101756,-0.0399478072711406,0.09250226167575192,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01634221127625353,0.045776975014745716,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04354121360485846,0.030818237591316976,0.15815853635743507,-0.01696865017015136,0.10405107737986827,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.05588427974087571,-0.006796624941690701,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056290652170099216,0.06974974109061789,0.41992585766598434,-0.08065901340469767,0.19324031774489608,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.2910797385366717,0.422026222179962,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007457256328845587,0.026060591708254182,0.7748494779067114,-0.043711239257252045,0.058625751914943215,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02881274545732785,0.05872310826539266,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0008404990938616964,0.025147349558497522,0.973347057872296,-0.04853489726287111,0.0502158954505945,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03380452601398873,0.04799467612584702,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02565808345757814,0.0327170334451774,0.4331698134200249,-0.03857995841694829,0.08989612533210457,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.024031676571963,0.016404249149701896,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0013171230344382898,0.02201984279858887,0.952320253794271,-0.044551837029412206,0.04191759096053563,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02470134836369088,0.045070644085121916,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027664390344736615,0.030831178323452595,0.3698823964705106,-0.0328708818247784,0.08819966251425163,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012220067420359427,0.0063721920890231895,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029890672810559724,0.03337442948084106,0.37077342069877073,-0.03563812894101584,0.09541947456213529,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.018516981967181136,0.014920164664821562,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017320196831230344,0.024827924076924652,0.48565881335054406,-0.03142802568666857,0.06606841934912926,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007607913142872532,0.0373785697333303,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,1.4776715323900252e-05,0.020373839486485704,0.9994215230163429,-0.03998810301614108,0.040017656446788875,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007644989183650904,-0.02384420475783918,0.999766777543677,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03677708118045855,0.026024288642264696,0.15805749544206504,-0.014320135391998869,0.08787429775291597,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.043194013930129185,0.08940659804857551,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002197594564455419,0.03063074980435175,0.9428260695205404,-0.05794414756131576,0.06233933669022659,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.020148537044743547,0.004840482237631882,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0656464381708383,0.046594117527093755,0.15931991635687998,-0.025838472214679845,0.15713134855635646,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.022129454818533564,0.1046995182697462,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03698419819751296,0.033684240532706855,0.27260563812919425,-0.029152900004787416,0.10312129639981334,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0019690326818179015,0.06017584079256711,0.8700354117066056,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022700373492767077,0.03923538654542344,0.5630708399566375,-0.05433608545426677,0.09973683243980092,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010042176817635728,0.02818333305996685,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08165380689610592,0.043596626193133245,0.06150378789301705,-0.00394569905162484,0.16725331284383668,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.005658292286301493,0.12077745088924037,0.5784562420554139,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02916671379961894,0.023585290258011544,0.21664266795645912,-0.01714166760530739,0.07547509520454528,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03327190104447973,0.07708782107277151,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004988328577872065,0.0448283379514689,0.9114299933600449,-0.09300623079132464,0.0830295736355805,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.06972128780789377,0.007411621652456965,0.9891894021454795,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030975147096449655,0.03454245623808505,0.37018065852949267,-0.036847009028716494,0.09879730322161581,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015335189784962643,0.025242028075499655,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005661490398603646,0.018663922669372987,0.7617241155825398,-0.042307045319929557,0.030984064522722263,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013268825481912449,-0.0035747071412141128,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0249990463519817,0.022558927645609073,0.2681800252397989,-0.01929413020301723,0.06929222290698063,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.06262381446625463,0.09182593883775982,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04787245373946868,0.02129151498442338,0.024866916248867648,-0.08967713732831965,-0.006067770150617713,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.008603280106414993,-0.08896254597427461,0.37244071921417243,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0026073201128860584,0.029522649476345145,0.9296514696862915,-0.05535872978849864,0.06057337001427075,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.10028069717715273,0.11912828716232447,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0835548238232221,0.025781721688542324,0.0012495634636910614,-0.13417577392253782,-0.032933873723906396,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.024722769593689187,-0.140623179778514,0.043314562335282296,0.4139440736449076 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03212709063572249,0.02155840021403592,0.13662400212276243,-0.010201606983443016,0.074455788254888,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.049598364904438634,0.0889498243723257,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04419318246672825,0.019856122846832,0.02636193865833925,-0.08317955490290493,-0.0052068100305515605,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0018714763277953021,-0.0665154352727082,0.38256136941480245,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03367996539649643,0.023294433178356715,0.1486814745015508,-0.012057334608471137,0.079417265401464,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.024738720485988273,0.053338586166753466,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031269884016252004,0.01796278123243474,0.08216628103001643,-0.06653878744313615,0.003999019410632139,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014989726723210936,-0.025086814226704595,0.6432307088917855,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020905365514748624,0.021346742147429786,0.3277669314923656,-0.021007753480257418,0.06281848450975466,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.004759543974808072,0.01940796427414917,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04042090739450509,0.019149639373655537,0.035153043517981535,-0.07802013955069223,-0.0028216752383179375,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.018174969495021228,-0.01744213249550145,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012452177375888588,0.01874031437346848,0.5066206110373229,-0.024343368329130338,0.04924772308090751,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.025635739709745767,0.04636082846449609,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04112932348457876,0.027959874369239166,0.14174830103804506,-0.09602695298840633,0.013768306019248798,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0095827137185393,-0.10937783004461656,0.7604630965928677,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029138106205838638,0.028850943726905654,0.31287531123140744,-0.027509087506088745,0.08578529991776603,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.06984504727915705,0.10131672192326724,0.9005091445086701,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016453101437502834,0.018594881775338738,0.3765657350437803,-0.052963098474295645,0.02005689559928998,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.008689126122460079,-0.023404931083047455,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04707182461193998,0.026455050581228656,0.07563302144229557,-0.0048711686266533355,0.0990148178505333,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.046845854262734625,0.09079779807991467,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044533163314380064,0.02051420207220635,0.030286574881541527,-0.08481163703190275,-0.004254689596857382,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.019490564458846327,-0.037215215586594456,0.4159426148956344,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00043589415545828496,0.02143165339480721,0.9837790427571691,-0.0425157315747918,0.04164394326387523,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.017594325842828266,0.014524165241930433,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0028314793702494522,0.019488461325566597,0.8845247413990621,-0.035433010495544606,0.041095969236043514,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0008537904642503175,-0.01953809238348165,0.9880940960671373,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07788269614045235,0.031333013616728606,0.0131698684081563,0.01636209879964398,0.1394032934812607,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0498129925728819,0.19137167610008107,0.2450248350502534,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056393885525007556,0.02756300576410177,0.041138909635188736,-0.11051228600373966,-0.0022754850462754495,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.02121855914529431,-0.06820058388713113,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09888846902392129,0.057260725298719006,0.08503516635905328,-0.013722260133146716,0.21149919818098928,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.024954985337060788,0.06783018598535695,0.6528134918357494,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07107123995046925,0.059213527138371365,0.2308367743784209,-0.04537993024040164,0.18752241014134013,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.045109448077540304,0.08027233276012928,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06876076292036372,0.03106857765876227,0.02751624162943493,0.007660328621385652,0.12986119721934178,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.055482119239406526,-0.02108312929877293,0.39228691037577734,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10911089381340536,0.060472734058528405,0.07202713119437819,-0.009816671999399479,0.2280384596262102,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16896255774764227,0.21689689400491954,0.620887427285682,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06227626962893766,0.043412698397833405,0.15230006331528873,-0.023100497705954348,0.14765303696382967,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06588241278633959,0.03549412196939106,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09384086439050608,0.03592090687887656,0.00936988410986694,0.023197688033396224,0.16448404074761594,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.09740736494850649,-0.06352472379715551,0.1983417068376634,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07187957583417597,0.052266281051307754,0.16991411253040892,-0.03090892341746876,0.1746680750858207,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08943495263279526,0.07802917886174704,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09165446752810028,0.033614979198692274,0.006714877012990072,0.025546200501851232,0.1577627345543493,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.0703273840520751,-0.0763689696026791,0.15751637494854673,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06363500091262958,0.033282208383860826,0.05667863685581687,-0.0018188286452697766,0.12908883047052894,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04962084153961675,0.06205606387781458,0.5568255190117257,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07585198568313825,0.05791468547336515,0.1911329828599607,-0.03804484195980125,0.18974881332607774,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16577706384286106,0.17764518074737573,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05319733180714468,0.03646550115175349,0.14548840165409807,-0.018516860640723755,0.12491152425501312,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01708600601186693,0.013543986350465173,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062394403200583606,0.06311463193914474,0.3235340302367702,-0.061728801422988686,0.18651760782415588,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.17577798842483763,0.17231788950282967,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04221592741549511,0.041600685627191845,0.31089356343900976,-0.03959727906194423,0.12402913389293445,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04790967576544069,0.036970120743207824,0.8977348514291958,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037067527929382074,0.030579711095069163,0.22625243196110179,-0.02307148613066614,0.0972065419894303,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03586001957045212,0.0056433900569967475,0.8420027214754927,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18909148166757422,0.08742841610439848,0.031218813259339194,0.017152030408403518,0.36103093292674493,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.06281877049204192,0.1264184347603936,0.42195400245230363,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19968798782441075,0.07165796965736838,0.005609638338012976,0.05876318865474617,0.3406127869940753,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.29288837965961895,-0.14294937107844463,0.1422661633455176,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009669783383627222,0.029354584596864033,0.7420366824927298,-0.06739942544301006,0.048059858675755615,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07015297137937354,0.028478161448401613,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06674909958040873,0.03858810371438448,0.08453311005085287,-0.009139469301596218,0.14263766846241366,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.030294505944230575,0.0386869927384873,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012088272354549323,0.03476807319221198,0.728283069251418,-0.056287705300922135,0.08046425001002078,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.061645381560115356,0.02861166044143261,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08340123894842984,0.037945647716067274,0.02859683502650092,0.008776144080147374,0.1580263338167123,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.006391850590136473,0.057062360948704434,0.4029256832771177,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029081341898175017,0.05321805672443534,0.5850936807292262,-0.07557894909179849,0.13374163288814853,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.040652432060744655,0.022211221482222477,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13127804633405474,0.05075646710706423,0.010092741517000896,0.03145879429794564,0.23109729837016385,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02189029893804766,0.09728108613606008,0.20399134085447534,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057799959044824774,0.03264112324983755,0.07745202634426893,-0.006393092483849484,0.12199301057349904,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.08069381525604494,-0.045531937514028197,0.6318748048518055,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1135994880252586,0.05857108156012439,0.053226129775359295,-0.0015882286443250765,0.22878720469484226,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.1253160828526922,0.16110951434457763,0.5411630668077272,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0589045556892429,0.034544276222708115,0.08902888720589604,-0.00903129586255979,0.1268404072410456,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.022302138530421765,0.024911454616943336,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04666009144924467,0.033391148076631676,0.16316743024473954,-0.019007982307851834,0.11232816520634117,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.010938324057867987,-0.04753533989291494,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05482432384831677,0.030561346843328164,0.07367354560886256,-0.005278574501212767,0.11492722219784632,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04845394857029295,-0.0314518782485145,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032605737298093185,0.03682521008444582,0.37652672017657096,-0.03981586996129703,0.1050273445574834,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04712594763993252,-0.0971356864114039,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05214173495738353,0.031732862372093114,0.10123307346352496,-0.010265102387414037,0.1145485723021811,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.007395332090026437,-0.015025118318452664,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06435561757824876,0.035141018591827444,0.06788103081352528,-0.0047538061376310725,0.1334650412941286,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06701676724884201,0.07739753118598282,0.6004485385751404,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018140499217192865,0.03442377422476413,0.598537621243047,-0.04955836934526478,0.08583936777965051,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0710607034998417,0.018510400585521336,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049972309342586826,0.0570643805657267,0.3817721370826225,-0.06225228213576567,0.16219690082093932,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0822837862011885,0.07235981549175634,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11372883668353617,0.057160617108479035,0.04739359033068091,0.0013149834172066638,0.2261426899498657,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10294359123816246,0.15415406811368348,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023822145444877697,0.03497227349958814,0.4962040443327719,-0.04495541890702076,0.09259970979677615,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.018550119627830458,-0.0015343455385719233,0.9429080290807693,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031188630528147732,0.05120627446141565,0.5428599313488911,-0.06951522668698201,0.13189248774327747,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10623940266027479,0.08842682833651554,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06710180220404954,0.03501361671603723,0.05610618303882089,-0.0017570690074065337,0.1359606734155056,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.013409040880047242,0.03909053845034605,0.5518846108576955,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016847508538507177,0.041522571850576416,0.685174234455372,-0.09850709402536377,0.06481207694834941,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.023867929542175544,-0.05981738305137192,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03326687285191832,0.03364345646183827,0.3234274537396471,-0.032897398448648585,0.09943114415248522,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.046760758566720705,-0.0761036359063639,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03057097455483626,0.028442626518292494,0.28317695427335743,-0.02536518229015449,0.08650713139982702,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.029457293103283405,-0.05878841579902814,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047826954746576056,0.029789779216266753,0.10927193799475328,-0.010758554631296185,0.1064124641244483,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03636989543120775,0.011074685433992709,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02058824101464362,0.03139362473780459,0.5123690429894432,-0.04115144101286697,0.08232792304215421,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.016753588541850835,-0.047424498332552904,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06257484363033412,0.035179877016420766,0.07613798855306782,-0.006611000275903417,0.13176068753657166,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07753969521909981,0.08834836749847488,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06062575274247053,0.02919116671730289,0.03852993492226078,0.0032174933843838877,0.11803401210055717,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.044127711386127026,0.050595077594166975,0.472721210839113,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013762704162662953,0.031255111913232096,0.6599613428910117,-0.04770457422183855,0.07522998254716445,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.044951221792338784,-0.03335372049456586,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05007129242180411,0.03309004284120456,0.13111791719622984,-0.015004618383503573,0.11514720322711179,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01882677314220573,0.04329332703217677,0.7360778123788349,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015077470866040157,0.028968183420004043,0.6030490362662189,-0.04189226258152623,0.07204720431360655,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0471298352649548,0.02434385035173197,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016223808359384286,0.032676449971368364,0.6198483147320768,-0.04803871780220042,0.08048633452096898,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08157292834387113,0.046566749314712746,0.9578267320115292,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05222586158369208,0.027921031470383124,0.06223456637720136,-0.0026845101640375277,0.10713623333142169,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.047493278522951723,0.08341893880163086,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03596061340925835,0.026541774074788835,0.17631619420767383,-0.016237267705443488,0.08815849452396018,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.030181743436921427,0.02884887205896953,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055307952578046014,0.030761793005789243,0.07303082261586726,-0.005189149449374819,0.11580505460546685,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.032947453618710265,0.02712391444258759,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11414536599766043,0.036639358276820994,0.001985809173598861,0.04208926070253295,0.1862014712927879,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.03018990791705752,0.09784818067520598,0.06374504020225781,0.6091919251481692 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016575001049571016,0.0348718481618866,0.6348554237739514,-0.05200506369949463,0.08515506579863667,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.09216685949728606,-0.21381409584143987,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11326647831486139,0.06105020871270526,0.06437744250954223,-0.006796767172577892,0.23332972380230066,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.018954937286683383,0.0681670620893324,0.5880149074273526,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06741949452264834,0.031189111399077086,0.031310394257014214,0.006082014808788255,0.12875697423650842,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.031019446313929066,-0.0042944186565951475,0.4219726818542934,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06676839110806332,0.03387485249856316,0.049492362388980485,0.00014904914110672185,0.13338773307501992,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06432505783934171,0.06634183220037211,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020019258142713665,0.05377737744386363,0.7099188912118068,-0.08574101042733576,0.12577952671276307,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.15164923073150355,0.05048794852220548,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04737972496130696,0.03905376018771096,0.22585837021143804,-0.02942461847165667,0.1241840683942706,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0026103081680170707,-0.026637324808255616,0.8409304609467143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10655532565435803,0.05176803456184893,0.04028450571430732,0.004746693496348639,0.20836395781236744,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16414083989436537,0.2238858038023843,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08076446915764965,0.04263365135667135,0.05898214551455036,-0.003080199956424362,0.16460913827172366,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08698702980565107,0.10924323565813054,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01746304211229483,0.037576824559871165,0.6424088050676313,-0.05643671362811976,0.09136279785270943,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09746932578163421,0.05977177356835998,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011497199501186004,0.02447782220631902,0.6388571096553184,-0.036641649464674395,0.0596360484670464,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04034976349228313,-0.10560372706107335,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0760676848868638,0.03565269821319842,0.03355888888026976,0.005951976060957834,0.14618339371276978,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07280724670334898,0.1628053099704124,0.43742275850834383,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043556155435663664,0.04132689242560481,0.29262216418662,-0.03771860078799145,0.12483091165931878,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04221274110889134,-0.0021265680696050384,0.8801950508955626,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1199692813945269,0.04396519284150078,0.006672414997233688,0.033505961246480004,0.20643260154257378,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09175752864837554,0.17725868563407676,0.15716804227905345,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10020976070272072,0.03963057321917566,0.011882169891209403,0.022271038762993883,0.17814848264244756,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.010997960835420588,0.049466020337859115,0.22774355289058826,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06139307395276088,0.032306166006659046,0.058192364039849565,-0.002141240209350262,0.12492738811487202,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.029110951345449422,-0.04400085861004039,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06146940485799915,0.03918859481911728,0.11763792270470917,-0.01560010856851729,0.1385389182845156,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04517189358311209,0.06077596964357664,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06652299694372284,0.03800802216494802,0.08093671142890489,-0.008224765462083616,0.1412707593495293,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.09655205114238631,-0.15254154459566235,0.6399159515165806,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041781838658493914,0.032363592839912574,0.1975343232413812,-0.021865412905861525,0.10542909022284935,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04228251623900068,-0.090192494464619,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07867523869056811,0.0353158985570245,0.026519398271793886,0.009221890578113373,0.14812858680302285,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.05675178973034936,-0.06615951793225601,0.3841441304406932,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02232173747509347,0.03332781168969766,0.5034417953292385,-0.04322177696708682,0.08786525191727376,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09646959901027066,0.06844519348309534,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027255188661604302,0.03657613590092541,0.4566633845501029,-0.0446765815362728,0.0991869588594814,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05887616164900936,0.007563588504836087,0.9353936944091839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026905357809120473,0.03217535980214495,0.40359611384434446,-0.03637170878946862,0.09018242440770956,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.021476138430242885,-0.004778288021673276,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09921853516316931,0.05964970372752237,0.09711928450828303,-0.0180904335185397,0.21652750384487832,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10669744197461639,0.1502479244262133,0.6756642247386071,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05864236289506728,0.029394034550313253,0.04679795520516533,0.0008351373262204323,0.11644958846391412,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.026482115952441744,-0.03836295497270291,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04813645546148792,0.04980010206817414,0.3344016174123544,-0.04980197924637559,0.14607489016935143,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.1439306888142846,0.11843124987048494,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03607515253565319,0.03245737968356332,0.2671173842998266,-0.027756543161984754,0.09990684823329113,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07339928121992886,0.07076216342616785,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025788002689321386,0.035667521865375584,0.47014667008537747,-0.04435685879351886,0.09593286417216162,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10017170257266023,0.06037057782359266,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04668436544881413,0.03407460595017231,0.17152814864713758,-0.02032781788925675,0.11369654878688501,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.056093730462820596,0.05189668310005862,0.7848027568782422,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026531513392627656,0.02992375167438576,0.37587110235690135,-0.032317470401906995,0.0853804971871623,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.038239667800118275,0.023768689066024955,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02072482221271944,0.037579979800264236,0.5816457608438154,-0.05318113872190944,0.09463078314734832,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06994834912871407,0.03459002400023704,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012953208242724603,0.030136035648333784,0.667582585076291,-0.046313259839162964,0.07221967632461217,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06307868168701641,0.02719027934124626,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04105634026940579,0.03119867793733032,0.18903046405606427,-0.020299953297100853,0.10241263383591244,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03746107336136502,0.01934815335239936,0.8093440257157704,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01955452215633733,0.024627185356907964,0.42771020751158295,-0.028878069042253644,0.0679871133549283,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05659682580386335,0.030428586693193566,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05854952975487018,0.03083761378867723,0.05841793187014152,-0.0020966837901175983,0.11919574329985796,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.025126206032857833,0.03458171921558047,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04895934424980122,0.02935025109712613,0.0961714004308327,-0.008761775413772946,0.10668046391337539,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.016445765536577058,0.018217628582197127,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035886033116471934,0.06892458851339946,0.6029288618942114,-0.09966321340203879,0.17143527963498265,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16437095873284457,0.18284796319417163,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08225649267859085,0.03901839982897971,0.03571482532582183,0.005521690030505663,0.15899129532667605,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.062237055820041284,0.11035539381705042,0.45290755634531366,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05080267973763036,0.04405259937479718,0.249588449750306,-0.03583253682626264,0.13743789630152337,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07556958741107107,0.06541101993175205,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0284002648562667,0.029008538738870403,0.3282275312909072,-0.028648832620644393,0.08544936233317779,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.03312163321816831,-0.05553756947108151,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06139737793578596,0.047716016883780236,0.1990239888169785,-0.03244242981589245,0.15523718568746436,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.11227955171337194,0.1239730652251888,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032294978390058904,0.03247480994752216,0.32067134284055476,-0.03157099620858082,0.09616095298869863,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.057117362483536584,0.02613202637717319,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08421310801774945,0.03644542112854389,0.0214208161194825,0.012538405570109407,0.1558878104653895,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.021846884691224637,0.04713598493992449,0.338048585201694,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021682649497438578,0.032255425470637304,0.5018802915584534,-0.041751876743205976,0.08511717573808313,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.026977450922169847,-0.008976177535430832,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0828156296869042,0.04391038606102098,0.06010454155881105,-0.0035399057364402936,0.1691711651102487,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0872503529529537,0.1055441642552205,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03615414193786688,0.026180110861804096,0.16814975092688597,-0.015332481016708047,0.08764076489244181,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.14340102888452824,-0.18695529418961643,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05684597821337304,0.027437664042456882,0.038999634816201244,0.0028862119325771263,0.11080574449416895,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.12683863757834402,-0.1341918720528269,0.4740874443660114,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05291300302270524,0.04532855165718491,0.24385954501499493,-0.036231541115013005,0.1420575471604235,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08933281506771193,0.07825222671615846,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08536917820360951,0.034698857957627394,0.014355551666149012,0.017129321388289584,0.15360903501892942,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05105984910259488,0.08526131895177404,0.26196406695607094,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034817529147719364,0.029017219000609017,0.23097695719556793,-0.022248639202788953,0.09188369749822768,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.06873841181013703,-0.10392488425986411,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059752568709865644,0.03685985200122706,0.10588450163755248,-0.012737166424045598,0.1322423038437769,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03562815597156817,0.02343545031555666,0.688943585244993,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01890491400639434,0.0283421760879413,0.5051876353442484,-0.0368336938877758,0.07464352190056447,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.035080239089991826,0.04131416360302215,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005366908970725854,0.029825169618465028,0.8572973466203075,-0.05328820027644457,0.06402201821789627,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.026608083017207514,-0.09142338936962432,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07288897385998454,0.03647440329178448,0.046435720743573376,0.0011572741857455299,0.14462067353422353,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.11244991945354707,-0.06998142873270326,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037392558767609496,0.03410822829784426,0.2736902232449531,-0.02968574732855707,0.10447086486377606,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.002110054001533696,-0.029412619830176307,0.870270919138952,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09443465870592654,0.03435017468582688,0.006278351134509016,0.026880533293369813,0.16198878411848328,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.14006184703185282,-0.08138170843323735,0.15242453109708493,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019241184054508607,0.030728881738441557,0.531610404576554,-0.04119119364757105,0.07967356175658827,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.022886331153495816,-0.07571922801291306,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10505697353606526,0.03748183102229528,0.005341383683900579,0.03134403505086049,0.17876991202127002,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.11317525884170888,-0.03049461677152581,0.13766202494416493,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04829207587096714,0.027797678856154147,0.08320195711882582,-0.006375706776479681,0.10295985851841397,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05338883352792425,0.061800777467618966,0.6475069956953327,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003993128330504681,0.027870431296125906,0.8861540517578959,-0.0588039881965937,0.050817731535584346,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.009520458265826946,-0.049716836415387725,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03323793517846607,0.03149594485558219,0.29199794753992103,-0.02870297278550031,0.09517884314243245,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02821213107039338,0.005939703536240654,0.8799526010712531,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026542071627081748,0.03035236995543532,0.38245320693524976,-0.033149846253726516,0.08623398950789002,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03957414422347849,-0.013084016215030603,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0643493686216596,0.049758486288674714,0.1967663219312548,-0.03350722319564635,0.16220596043896557,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01575393449433669,5.515706065860604e-05,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06633338187012158,0.04115757037832257,0.10791237611771891,-0.014608380331761206,0.14727514407200437,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07262570055288736,0.06520783606654046,0.6967044957001925,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029828251051392963,0.02130457821411127,0.16235587479801863,-0.012069997260325978,0.0717264993631119,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.0566930481820351,-0.09369073586548203,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052881497109557446,0.03456428761505486,0.1269156424601621,-0.015093709470877167,0.12085670368999206,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04254207482142169,0.03508298760833427,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055739032928648596,0.03067355521218973,0.07002951741163999,-0.004584537900475062,0.11606260375777225,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.013620753805594374,-0.028034748324400064,0.6115448946244205,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06064297830866555,0.03717281814336002,0.10369203586017703,-0.012462245806274294,0.1337482024236054,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05542598474785137,0.0496263588560022,0.6847815146905868,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0600156473861292,0.03127984682525369,0.05582351154930882,-0.0015002754481912017,0.12153157022044961,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05109232473616118,0.05278287401691105,0.5511530282069819,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051820072064148875,0.04033663734795431,0.19973360484259242,-0.02750721762351728,0.13114736175181502,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06178230389849286,0.05039645143490886,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06835523436709284,0.03468219372322845,0.04950710879482383,0.00014814995513874607,0.13656231877904695,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.0593090663537233,-0.0457661315265997,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053598682559424515,0.048110792858526215,0.2659996036316219,-0.04101750394292318,0.14821486906177223,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.12481614278135586,0.09159180063610799,0.86964779803452,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08048236815123175,0.03957195419580197,0.042708398729143726,0.0026589282120410423,0.15830580809042244,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.008655796032688116,0.04141729803908803,0.49583625418844224,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09186142964933047,0.05539689844133103,0.09814708827231604,-0.017083839450463642,0.2008066987491246,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.11510208571719435,0.1404995381071609,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07068861821993619,0.049286935246309324,0.15238303135891282,-0.026240606603002856,0.16761784304287525,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.023033630972965152,-0.0026316340478836076,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06516440987137671,0.040020544929255324,0.10434894577447658,-0.013541242602212608,0.14387006234496602,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07367234283079833,0.07724482555841505,0.686265063428165,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01186792978720667,0.02811494906687059,0.6731902914836864,-0.043423806356850767,0.0671596659312641,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.004188748433528197,-0.06911004662071653,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0791124037367826,0.029870111708017504,0.00844274058264252,0.020368909973908896,0.13785589749965632,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.1378520479771287,-0.09193716433478452,0.1877705709914981,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0390792406063368,0.03783835991439969,0.30239933058388163,-0.113493339936012,0.0353348587233384,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10559042093349404,-0.07060241208442347,0.8904632102898862,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04833681875196914,0.03738863156764726,0.1969089204193321,-0.025192830777494984,0.12186646828143327,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.020294271548911186,0.019403720392217133,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07050701642631368,0.05479737684288967,0.1990374786486636,-0.03725921479029451,0.17827324764292188,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.12061309449075623,0.10731141644100259,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08130056033853258,0.05535777267234352,0.14281141115965038,-0.027567762803075893,0.19016888348014105,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.004489407232021173,0.1293158709485105,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013948305889322448,0.029560852881340617,0.6373216983856347,-0.044186989814783,0.0720836015934279,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0026009863981335574,-0.03269394834197577,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07228817559509619,0.034455344660376024,0.036605390746412676,0.004527219628828766,0.14004913156136362,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.045975426973104444,0.08153765846185258,0.4586714357798637,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013869143803484727,0.03216714756637018,0.6666132466101455,-0.0493917723559721,0.07713005996294155,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02792521733714473,-0.00529114180131325,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06895610906589877,0.03325799296045235,0.0388546819266835,0.003549902315301459,0.1343623158164961,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.013893870030735798,0.03942674038340876,0.47377644413826986,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012524070374177493,0.02881373985340973,0.6640746116825311,-0.044141929536011,0.069190070284366,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0036218982691468287,-0.07048232518352852,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029330895377357412,0.03265412349635825,0.36966862417476276,-0.03488772284178892,0.09354951359650374,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.052537475536131036,0.013620581573766938,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07835454379626104,0.048098404798519075,0.10418519839227172,-0.01623727996071507,0.17294636755323717,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08738053789470844,0.0919624388123507,0.686265063428165,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04551326150953034,0.03826809673467721,0.23510163187601194,-0.029745971660567493,0.12077249467962817,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06231811747665831,0.0682908940821308,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008743601943794409,0.026654001945470872,0.7430730686598671,-0.04367499000339023,0.061162193890979044,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.009305042911294477,-0.016827867308944235,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08679599149896011,0.04724353758084505,0.06701089296897281,-0.006114623712149048,0.17970660671006927,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08133347155309283,0.11346275365562009,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035166572908428645,0.03683385191680583,0.3403576711140073,-0.037272029648143676,0.10760517546500097,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02312934402953207,-0.010003511706227083,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05551824126439116,0.035643548351561125,0.12021511714800096,-0.014579473158103276,0.1256159556868856,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.05771631107770637,-0.08218438821515926,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00812043109167377,0.04148018810846729,0.8449043139897598,-0.07345580120539325,0.08969666338874077,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08976255538720297,0.019561609286409175,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08234899484390285,0.04079781417985108,0.044290118301516364,0.0021147404078980386,0.16258324927990764,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.02380760222206846,0.02195263799264643,0.5034452685637203,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10504361001032608,0.0446900546340424,0.019292186260504284,0.01715475404221445,0.19293246597843772,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03510330727025551,0.09133445879872043,0.3170765275914746,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04574211378164915,0.04215872145862391,0.2786548349307849,-0.037168543375038596,0.12865277093833688,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.040602649362944415,0.07823301424249925,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07400238960307509,0.04319408790271651,0.08753420566906932,-0.010944451510518219,0.1589492307166684,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.12655021392537305,0.17335949889292654,0.6570553152600204,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09261241823427827,0.0529109197780056,0.08091765235446818,-0.011443847652832947,0.1966686841213895,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.00901868811165397,0.08675809029923183,0.6399159515165806,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014192596261920834,0.08299874967168772,0.864322440390098,-0.17742052728959168,0.14903533476574998,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04747582927493209,-0.2628759804537945,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040595465631370044,0.04432729303459431,0.3603837138456527,-0.0465799720555214,0.1277709033182615,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09890088918098133,0.09542080965340512,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03158756880935216,0.043333393420289926,0.4665145269894174,-0.05363323488204134,0.11680837250074566,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10029431012337794,0.0837874568390061,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07735663672098497,0.037830219080854335,0.04160382782531092,0.0029585474085896124,0.15175472603338033,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.05993324536789423,-0.04659574071224003,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03896866267948754,0.035607778963955956,0.27452344995959294,-0.031058706549181525,0.1089960319081566,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06876821653357518,0.0592682719453535,0.8709804306040525,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06718683921726407,0.03535431609349948,0.05818786673436036,-0.0023420620212172144,0.13671574045574536,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.005990418524518918,-0.0011563419849518555,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07871886169815914,0.038417179770584446,0.04118742929534647,0.003166437177604578,0.15427128621871372,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04150119856205437,-0.03011465867062129,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014183704399191067,0.03700644604891743,0.7017428241703149,-0.05859432716328231,0.08696173596166445,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07192052108846388,0.057000923651595106,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007012434399246398,0.03524482967095496,0.8424045667104287,-0.062301147424204464,0.07632601622269726,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08825841043791612,0.042271852728871497,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006791612521611555,0.038347593981220444,0.8595250836253077,-0.06862396241419935,0.08220718745742245,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.054161433755973924,-0.026137613037361028,0.9839789607467108,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12242256787939126,0.0382704205801544,0.0015030688394490194,0.047158764562263866,0.19768637119651866,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.038178856450718925,0.05170972516076065,0.050556612065874224,0.48315413615957226 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06469313831566967,0.05988119278325401,0.2807119975040008,-0.05307108396651032,0.18245736059784967,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07750024239716859,0.06331062187450341,0.8762453150557444,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07716912212080153,0.03749742124873572,0.04031713403870688,0.00342552340979585,0.1509127208318072,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.01878246022883843,-0.012657593249082218,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09118108648158915,0.049116307112686934,0.06421566109578637,-0.005412575729425426,0.18777474869260374,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06701988554242523,0.10271885402553402,0.5879399282333936,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08853419359231293,0.047785549907162224,0.0647447589189094,-0.00544235997288238,0.18251074715750826,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02293635543783368,0.03349884013521444,0.588665895017662,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018525366605858625,0.031043630143681524,0.5510508158190428,-0.04252600513149027,0.07957673834320751,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04096185712569916,-0.020267604908556777,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1377393411520449,0.04736390333742523,0.003863674119582942,0.04459201088810806,0.23088667141598174,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.15212631730811174,-0.07822547460468968,0.10548035157916945,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019159674929120796,0.058307049354515875,0.7426509890232335,-0.0955087877659557,0.1338281376241973,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.1415848789230047,0.09035459711721004,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0040648887104999705,0.03094578694275504,0.8955683529790316,-0.06492383895577182,0.056794061534771886,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02727068055907856,-0.05534480213311201,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014469668897252468,0.03510160897898559,0.6804238487148779,-0.08350158843876555,0.05456225064426061,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01318132471775915,-0.0674852924072117,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06510806687182415,0.03239013287339016,0.045170267956317116,0.001408620849466788,0.12880751289418152,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0407873864354402,0.02370220627479293,0.5090185993885504,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006810948731224502,0.042015550325183094,0.8713145416835453,-0.08944004106932316,0.07581814360687414,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.005325187330461094,-0.07286787575511719,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10057007894858735,0.03577842990024159,0.00521263574361583,0.030207102263564753,0.17093305563360994,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03065035799978471,0.039515941076773115,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01656837011128514,0.03186519361365191,0.6034193091795805,-0.07923545420504466,0.046098713982474386,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.014343177298757299,-0.06863620038709366,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06081116090964131,0.027749804145549423,0.029067854626218276,0.0062375301619697066,0.11538479165731291,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0380931733505228,0.017014020460949165,0.40623350356148,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01757382458926242,0.03349186106239471,0.6001040382746592,-0.08343996364684535,0.04829231446832051,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.040635762456118246,-0.03399382209705154,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06781542638997254,0.025743602116316162,0.0087990912795509,0.01718725515525267,0.1184435976246924,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.025923269296904344,0.038681149276206556,0.19294802921843934,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020697126705201272,0.03217919055831528,0.5205178983683291,-0.08398172698841125,0.04258747357800871,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06467960660472273,-0.017103738594295464,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05175911835484229,0.02814044088161929,0.06669919612601076,-0.0035827507875558495,0.10710098749724042,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0010320916712397907,0.005859860728485984,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030086211875194904,0.02942637903490609,0.30727297608715576,-0.02778462336634134,0.08795704711673115,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.018529694779357744,0.0008203192542326939,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003325703701768398,0.04076813289931758,0.935029553072016,-0.08350158600529049,0.07685017860175371,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07292242802972737,-0.037367124828143215,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02894868301713674,0.028184978545762244,0.30507059119214486,-0.08437814131960797,0.026480775285334483,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.014747614871556238,-0.08670246499292224,0.8932682968953323,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06463397762936646,0.03192201262830369,0.04363737494698936,0.00185515148839141,0.1274128037703415,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04338712136248771,0.07245584578913368,0.499126055229397,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034430272118314995,0.033663285479129626,0.3071025097809445,-0.10063353978303897,0.031772995546408986,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.025503229277272454,-0.07722923292772667,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09156480275623806,0.035191506578311826,0.009656845801809808,0.022356087790692453,0.16077351772178367,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.016458514323609983,0.05167523277736324,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011634813157549172,0.033771044691637234,0.7306578319131134,-0.054780377137050126,0.07805000345214848,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01895315523832439,-0.016380805605036325,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0018814089147453292,0.026317891384395234,0.9430495418101787,-0.05363899534440179,0.04987617751491113,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06018828215089807,0.014986322982254729,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01583467608388926,0.03125803003039623,0.612762636495705,-0.045638341160885235,0.07730769332866375,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.030093378144944883,-0.11059926382566422,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06406653829460977,0.025685706785959304,0.013073990389292097,0.013552225823156759,0.11458085076606278,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.030215275165076185,0.001987370753918414,0.24476730120330345,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012650763123848148,0.09292723938640463,0.8917773045044733,-0.16999737198336462,0.1952988982310609,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07615955560714956,0.15255748025604177,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08369919655140126,0.06942959960942255,0.22866321656389288,-0.05276441706323892,0.22016281016604144,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04583067723263599,0.19890794578278134,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04070100893803805,0.05598651325990073,0.46763451937659517,-0.06934026965365289,0.15074228752972899,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04398046125675697,0.13790920490005745,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013732613760915568,0.09596919055129882,0.8862829853191834,-0.20235969229767373,0.1748944647758426,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05636695781987372,0.11167832024409097,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03289611776572943,0.06748937898998394,0.6262044541677779,-0.16554623514205494,0.09975399961059608,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0927483968677288,0.07023985897643156,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04128604834775113,0.07233406128593367,0.5684543084734337,-0.10088627363063646,0.1834583703261387,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08350292544506531,0.17372593269442976,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02047994423998243,0.08860091757774737,0.8173096010341598,-0.19462471030876746,0.15366482182880262,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06917865239038311,0.08749940290706713,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017024211643061223,0.052515534733033435,0.7459633456987197,-0.12024329515916873,0.08619487187304628,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10734037718233162,0.10373168364320554,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005180930770990171,0.05318374421770462,0.9224416800629202,-0.09935151594241037,0.10971337748439072,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04731301495069179,0.0686124291292128,0.9911128933864998,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01701466137412532,0.0865294970549844,0.8442066796441624,-0.18708805829427713,0.15305873554602648,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04935328230364774,0.0870677529412198,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030854588329462654,0.051302860562288576,0.5478769216426975,-0.06998098872242896,0.13169016538135425,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08515248717231735,0.17472036311657374,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009159676915384326,0.0926391967459349,0.92128379722296,-0.1912416653097437,0.17292231147897505,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04613839850972807,0.0749128005968307,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0020634400307029312,0.06126910054643192,0.9731492989725276,-0.11836074375430804,0.12248762381571389,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06843046413553475,0.11430070105707756,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012435830957188624,0.05139535992649489,0.8089233491799479,-0.11345321515715051,0.08858155324277325,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07250600654551465,0.07554280564584132,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014352920210170367,0.14195287689511807,0.9195099052034537,-0.2646549187097737,0.29336075913011445,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08104537505342427,0.15979618842926824,0.9903757974905041,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006605719181549995,0.12974839362193405,0.959419474807909,-0.26162569270795527,0.24841425434485526,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08453423433247619,0.11239586806269465,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00021890106142673335,0.056043516337527625,0.9968853521660579,-0.11037221898510118,0.10993441686224771,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.021266900443667257,0.02566404666410159,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000599532632451103,0.0621953957276753,0.992313379943567,-0.12164528080356457,0.12284434606846678,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07458842960666423,0.12959421396193116,0.9994603233931454,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022976657405934534,0.060362963570041346,0.7036571485692928,-0.09566651760293882,0.14161983241480788,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03776906796265456,0.08769959481935508,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02598172904321441,0.05412818807653524,0.6314688541815467,-0.08040701847787061,0.13237047656429943,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05246502214589715,0.13044583187523223,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03630517132460641,0.09447312423614491,0.7009527467889181,-0.14938139456737864,0.2219917372165915,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.041168077005496656,0.138168048408324,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048011577756591865,0.0844185463336907,0.569834543324548,-0.11791275356026248,0.21393590907344623,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.059929007301250344,0.17299224379968378,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0768912889443214,0.060582027921295085,0.20505286980667187,-0.04218245621265021,0.195965034101293,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0114837887196014,0.1358483897369449,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029711513444272204,0.08941860751570846,0.7398439862838541,-0.20546344597200594,0.14604041908346155,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08930846887025007,0.1058193342872327,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0317037793051469,0.05135448539441214,0.5373295363742868,-0.06923326615767408,0.13264082476796787,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05626012081926553,0.1234533585540368,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00884793561450725,0.04921770520139151,0.857416723155247,-0.1055851477457212,0.0878892765167067,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.11959418366988527,0.14272521098292235,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05234971259615614,0.04808919903631117,0.27694179458649026,-0.04216942496542766,0.14686885015773993,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.030077568407855394,0.12603943769434195,0.8725380346331878,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002116633329272945,0.05231064134785908,0.9677429697769472,-0.10069973301859622,0.10493299967714212,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.13955806968852918,0.1674975611097711,0.9964902962886765,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024765108985707985,0.0608566346943579,0.6842532114182048,-0.09484837473789827,0.14437859270931425,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.052243981662382324,0.11652966752293936,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019499655306822348,0.043644205632999776,0.9643841674413165,-0.08773248548649794,0.08383255442513347,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08519831867032343,0.09880826647215424,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016241239071079164,0.0475675574541787,0.7329427550047736,-0.10973509208961636,0.07725261394745804,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08374513397953426,0.08404032628108464,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0037771556477330967,0.0842207082675561,0.9642490447521839,-0.16931263699905205,0.16175832570358586,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03188828936610774,0.07198882966564926,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0030702765488663966,0.09413936384772585,0.9739974083588778,-0.18810083766851643,0.18196028457078361,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.050482085423795155,0.0886486424843322,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02454286875203729,0.05408931212663614,0.6502397740474034,-0.08176946823757734,0.13085520574165194,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.031714344147201784,0.09307533203174694,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04220606413558116,0.09336105715601208,0.6514439573256812,-0.14129473814563098,0.22570686641679333,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.017955694550904913,0.11113817942241143,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037005737417780224,0.047805466316351033,0.4393029089192294,-0.1309671993988582,0.05695572456329777,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10046490582228677,0.059774562207876636,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04842936015037064,0.052903806861912185,0.3604826879948274,-0.05555287075634134,0.15241159105708263,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0637303808676496,0.12613606562444835,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021093685654512754,0.04994293807166738,0.6729764950188053,-0.11925634023025625,0.07706896892123075,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.1315355484697135,0.08770192418576578,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0015758893004794317,0.060877957041463135,0.9793602425731505,-0.11807950341515754,0.1212312820161164,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.051222758436104375,0.07423675971632826,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022344246775115786,0.035326788654437856,0.5273954072847384,-0.09177891533585758,0.047090421785626,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0897422686554556,0.07262144673216431,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001301451111587893,0.06208411724874343,0.9832851288621163,-0.12332754712105912,0.12072464489788334,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05260427183089662,0.0791003072221656,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005669543667321582,0.04303245399134765,0.8952433303321242,-0.09024966810128256,0.07891058076663938,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05790168892422207,0.06214177546948054,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009947831731389472,0.052440333896100234,0.8496352219426381,-0.09312344482612286,0.1130191082889018,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05564542247278877,0.07582626429927965,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04226383412982148,0.0500389166573468,0.3987931097700319,-0.14061513425019026,0.05608746599054731,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09294580722611796,0.05740948343918817,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012093614786568245,0.03334155127671663,0.7169930085944347,-0.05343907726889749,0.07762630684203398,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04360083172324145,0.06076981354148944,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003800766265368981,0.04529991157112193,0.9331731657031982,-0.09283756993692577,0.08523603740618782,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05743394106030372,0.05881152429363633,0.9920354344920299,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0009849004128999416,0.05051020738014115,0.9844520495161058,-0.09829271982824402,0.10026252065404391,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05433694758243581,0.06985837881158068,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02558664941462015,0.03478994679254059,0.4624597287385912,-0.04279285851108652,0.09396615734032682,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037601258086509534,0.06406990010273378,0.9372011503139762,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026115735370463623,0.037587843666900225,0.4875608691369826,-0.0999944989471334,0.04776302820620616,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05951878785668647,0.01024994448240192,0.940275458344982,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012084227278356861,0.046028173621768795,0.7930310432565919,-0.07838397268021224,0.10255242723692598,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07404582998953102,0.1090628876735795,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009558788390797745,0.04381340906589829,0.8273998562476809,-0.0765563002679808,0.09567387704957628,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.06255398082664675,-0.021246827784119585,0.9810156921425078,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0195596747411152,0.05914296362326129,0.7410181815320569,-0.09668559501864477,0.13580494450087516,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.19659175862054745,0.20893763778038343,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1138373731642073,0.1074409608738397,0.2899513493450386,-0.09733742625208561,0.3250121725805002,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.044503766458350816,0.23141408816352893,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029730700452739872,0.06270627362449847,0.6356504252552286,-0.15297964244931944,0.0935182415438397,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08712393390409483,0.1074843761195004,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021801898232994266,0.04449067139375611,0.6243604533155733,-0.10924814341787205,0.06564434695188352,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08166337893013226,0.07263701293656963,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041395059667788475,0.08024379940721064,0.6062130402473682,-0.1991139417998723,0.11632382246429535,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10528341681606455,0.07437080028996794,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009260869419075878,0.0546170508552536,0.8654358889274562,-0.1166104748699328,0.09808873603178105,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08913257941938581,0.11081633265754373,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033423241975687704,0.06212656368231054,0.5908648222962901,-0.08868628233730547,0.15553276628868087,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05765825500906733,0.14035372034076074,0.953309951095112,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008563739265139331,0.05318311992982163,0.8721504098075846,-0.09596748041280476,0.11309495894308341,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0669326411968094,0.098138976237549,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0015120992315464446,0.05763411280020851,0.9790811257923995,-0.11176752998185407,0.11479172844494695,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04826510749159313,0.07360258513754239,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010754728162199226,0.04009786859708224,0.7886647837685256,-0.0680574798554923,0.08956693617989077,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10568887534883467,0.11413601539876994,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01542951905597703,0.04700634289312373,0.7428874563647234,-0.07696126888015227,0.10782030699210633,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.007474088399293379,0.055415100406695686,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025433673383097724,0.06271747165711747,0.6852913423471644,-0.09783727830394758,0.14870462507014304,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06971254806201517,0.11211428750303419,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017921206691612127,0.07026066045928435,0.7987929623554719,-0.12017585385839544,0.15601826724161968,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03563491895988594,0.11759086503215502,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01472059461233334,0.07457860166936199,0.8436206120176782,-0.13186336294151063,0.16130455216617728,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0650850455866099,0.11217324879975342,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03268626706758087,0.06460747329339964,0.6131714801199875,-0.09429947563764055,0.1596720097728023,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06750359529513318,0.13871442305880496,0.9552990821084932,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02068443419563807,0.07629661731401308,0.7864399694017942,-0.1292762765648275,0.17064514495610364,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04094163243566542,0.08779595765783078,0.9723925976809099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018063394235668398,0.053173361314176715,0.7342426112922843,-0.1225754333917274,0.0864486449203906,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.1511996098293475,0.15048065777460976,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010259691649396815,0.0649560537316426,0.8745717630264889,-0.13793056787844105,0.1174111845796474,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07941918194203593,0.08008876701076903,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018630686786788635,0.054674881937096347,0.7334551753904389,-0.08883258543518466,0.12609395900876194,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10338143951880306,0.1421778008646069,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00562256309778178,0.044775299304383676,0.9001287230599393,-0.09362824335701295,0.08238311716144939,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07103156974436252,0.06476667040277914,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013949326071439934,0.049170985273576516,0.7767843552384145,-0.11059471036246303,0.08269605821958316,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08274584462963398,0.06357038858147612,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011182763752259363,0.05170118964354226,0.8288595496491138,-0.11280125509634718,0.09043572759182845,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.060633340866106375,0.05702889140633241,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001336154168379264,0.08505177458938482,0.987473121908331,-0.16850509321019574,0.16583278487343722,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06141670928110226,0.15323753220605293,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004421466138361451,0.04778032624195355,0.9263141916000972,-0.09833351539895537,0.08949058312223247,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08957463231720689,0.0865932590074357,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00828702238615903,0.06564798421689427,0.8996055226669066,-0.1373178853487975,0.12074384057647944,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06807028387967501,0.08888898009178975,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004829235599592368,0.04418136470895946,0.9130117231977992,-0.0916675396734748,0.08200906847429007,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.061737555860909205,0.060820554236261065,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025015886395696206,0.04432524468178609,0.5727958729365814,-0.11213698600821276,0.06210521321682035,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06052437219906237,0.0375293048743372,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005421374583774518,0.05020270809248888,0.9140542450025504,-0.09325185697857803,0.10409460614612707,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.043594933859585565,0.06641653110573113,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015222133372794742,0.05061699277344539,0.7637644587327858,-0.11470963989779363,0.08426537315220416,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.02835234395141616,0.03679240697874871,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025360736392711275,0.05763814174982362,0.6601587570844183,-0.13864828449123628,0.08792681170581375,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05878498298532253,0.0650541618406142,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021880922372787586,0.037205730571440526,0.556769725554707,-0.09500864411558181,0.05124679937000663,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.040970300815301335,-0.0071540634782847785,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014097577382465472,0.042011394847685436,0.9732463363988797,-0.08398299431397038,0.0811634788374773,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05960342645803529,0.06267490529598452,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014049164082681767,0.03910996064957032,0.7196052377450008,-0.09091964279191561,0.06282131462655208,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.023029860021637646,-0.01227829042100593,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016085832412382747,0.04889041822484441,0.7423021951394945,-0.080008098412877,0.11217976323764249,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0520210614689978,0.10518157017881669,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015407338847708773,0.04478441884142347,0.7309892899332006,-0.10343094352226055,0.07261626582684301,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05829242561653942,0.05559208624423585,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0527268117813328,0.09066733252267828,0.5611803144401609,-0.12547948499191997,0.2309331085545856,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.014686595675681315,0.0546744969460558,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02165256986495597,0.06374484720033634,0.7342666773298037,-0.10363768453959951,0.14694282426951147,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05207401787565284,0.13336525578919364,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021821656426494775,0.061762045248032166,0.7240230297309531,-0.14321472114515627,0.09957140829216671,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06628575957074291,0.06607949984772829,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027216589742554795,0.04252958634736078,0.5225492707879296,-0.11080832973739514,0.05637515025228555,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05750274589090944,0.04967889024433245,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015090142588673163,0.0699808454216113,0.8293764869540066,-0.15263722774778998,0.12245694257044365,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04375901655722175,0.07638802927403923,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006582663107063755,0.043886801412017874,0.8808413628872577,-0.0796766779285033,0.0928420041426308,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06586441813806612,0.07317706856844435,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03946616891075669,0.06539295653400048,0.5464788823475204,-0.08906343811240877,0.16799577593392215,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06122431522869683,0.15948683809366893,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005252834975738603,0.051449354801655814,0.9187271173286933,-0.10637634589719365,0.09587067594571645,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08292627559722068,0.08102889978839012,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019016668643478837,0.06905242448280177,0.7831453354306788,-0.11670560869623281,0.1547389459831905,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06568071614736343,0.13724917988364066,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044171852711382166,0.04411144806454528,0.31721143402408486,-0.042529030464176755,0.1308727358869411,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10247901709038564,0.1699182943396505,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019536336471801887,0.05064733360882262,0.6998853475650424,-0.08001080484958005,0.11908347779318383,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09778915572817563,0.1625517561038265,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0110065340831076,0.06886303865524204,0.8730882733232193,-0.12434350613379781,0.146356574300013,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06814774162044215,0.1060098634238931,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009787129051703407,0.05019892334251462,0.8455109365597071,-0.08887866359898867,0.1084529217023955,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05695548900909485,0.1043965989892977,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04064965640981399,0.05240933654199539,0.43840056623778034,-0.06236069496625648,0.14366000778588445,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07430771927516931,0.134030978494478,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01474116588142792,0.05201820179021991,0.7770182894732416,-0.1169827433924925,0.08750041162963666,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08225650792834009,0.047590523286646945,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006134746410562422,0.0347886396251066,0.8601072021676845,-0.07451168510365586,0.06224219228253101,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03472387260421542,0.04473451233035597,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006684749600831957,0.06349397681213932,0.9162014289765754,-0.1314819192128082,0.11811242001114428,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07624030242068938,0.06951077196487407,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0671233549224015,0.08381698402809369,0.423670945610245,-0.09761860797380907,0.23186531781861208,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05714547872923205,0.1735563558917501,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017964230421922682,0.058034128795599105,0.7570561976464534,-0.132030089550831,0.09610162870698563,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07351240312252534,0.06556118004346566,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07393387443493016,0.07238933347279683,0.307669258844228,-0.0683470848162368,0.21621483368609712,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07595001171580888,0.21755460675255806,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014527440684252393,0.061820747617658336,0.8143260578499649,-0.13603588468685035,0.10698100331834555,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07807131718855342,0.04718223911853587,0.9769437249386967,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06415710654949586,0.07321133755059588,0.3813413168413865,-0.07973949858604121,0.20805371168503292,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06603443134563824,0.19584941390769622,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013975810676575572,0.03327716144738069,0.6747083326696831,-0.07938194476770558,0.05143032341455444,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.02947838401105274,0.0009528710518422849,0.960515556802716,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022200760991425796,0.04312286508113899,0.6069393199033436,-0.10695858807804745,0.06255706609519585,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.056365920927463634,0.02550960494939258,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008784707662504413,0.03765059423841885,0.8156224936207384,-0.08278680724851298,0.06521739192350415,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06418922853800908,0.05549705487930428,0.977649408210028,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014841311419095865,0.05219345977309792,0.7762775685945285,-0.11742735782804964,0.08774473498985791,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07666340829672189,0.06888599795294081,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013282762887897426,0.07026922888677754,0.8501610484826025,-0.12483113887371577,0.15139666464951063,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09397214593568304,0.15131934320322973,0.9831844992504223,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037280341461703156,0.05856486160904616,0.5247469344390593,-0.07782867099077727,0.15238935391418357,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06996326781499226,0.1435983685658717,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031039438978013038,0.04051110385396217,0.44398018513352966,-0.048584981363299,0.11066385931932507,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07249206152096689,0.11516076274957228,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006865767992007267,0.04893796054960585,0.8884923359466619,-0.10305314307552406,0.08932160709150953,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06112566879314529,0.0781639085287728,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026086899852032226,0.04400426959050502,0.5536088678451035,-0.11257712414504659,0.06040332444098213,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09986471377361889,0.07599388536048285,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02218383069298338,0.05109448186068082,0.664380781903747,-0.07824217881449362,0.12260984020046038,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08662428397515444,0.1479837867337715,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00024322766184435877,0.05225111041855633,0.9962880387536059,-0.10294258619488827,0.10245613087119956,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05248254016052473,0.0733801258583214,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029463789653154767,0.04696010930630725,0.5307158926480456,-0.06283612634416406,0.1217637056504736,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07486256434647993,0.12151887990060303,0.9460639469661322,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05196116346246444,0.06024305244873743,0.3888792351503182,-0.06644632669415901,0.1703686536190879,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0805910492872654,0.17873266333618298,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027840778884405924,0.0712280093049327,0.6960880877525355,-0.1678391599064562,0.11215760213764436,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08192879415412421,0.08677366228917856,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022666411465211405,0.05568693399394273,0.6841863950046443,-0.08678604522016535,0.13211886815058815,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07832566767966431,0.14266800981019295,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010418155272511245,0.08117317386217014,0.8979361120613606,-0.16996371935636162,0.14912740881133912,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05795084301635876,0.09081378285895218,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0418021324926764,0.08127863312083321,0.6073019071404813,-0.11795071136244215,0.20155497634779493,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06802934952773342,0.1525855498548508,0.9534736034179471,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00501813526726823,0.058648509123055984,0.9318537330471907,-0.11025528605543292,0.12029155658996937,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06973022263529421,0.11429330607935237,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012177980554682213,0.048677133971867965,0.9800523180892963,-0.09445692338284419,0.09689251949378062,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0911196534146544,0.0997407021018082,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03627871943914025,0.05842703697733101,0.5349789513628307,-0.07855939922459933,0.15111683810287985,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03222859477675963,0.1169751961358892,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048761465512326366,0.05814762976675147,0.40217069714669373,-0.1630504103677743,0.06552747934312157,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10466277797119362,-0.024104955678517496,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018185001390230653,0.05441597970992318,0.7384029263994838,-0.08876939949024445,0.12513940227070577,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.051416359928524794,0.1012158744572236,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007184005876291702,0.07616092944120618,0.9248936123362906,-0.14251001088692952,0.15687802263951292,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09695032232254773,0.15682923121199457,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018884266037307768,0.04148255726011665,0.6491707462273633,-0.06264954227408986,0.1004180743487054,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.02849337400060201,0.007654725801962546,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015680870331893946,0.0450392454402628,0.7278902954525368,-0.0728435950521876,0.10420533571597548,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06153356430446378,0.07463413706674145,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015010236153598317,0.04163222435207179,0.9712557373261146,-0.08332900202599886,0.08032695479527918,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04824613958896413,0.07630000724617361,0.99739043245727,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002482146428203124,0.05534705625334267,0.9642501241263471,-0.10630228185242437,0.11126657470883063,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04176912828956096,0.05294911679324441,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024233070918050034,0.0427696690509759,0.571285137247407,-0.05983055071640797,0.10829669255250804,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06341554885484338,0.11605944541452926,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00586240645129551,0.04184805589843397,0.8886561310923686,-0.08811460094433034,0.0763897880417393,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0866791028707688,0.06593210882117925,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014247264988784196,0.053002269860831966,0.7882088138932835,-0.11842302454488368,0.0899284945673153,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08386376841263218,0.07392276962545907,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02102957141423666,0.07888402218597619,0.7899138201477127,-0.13401667376812543,0.17607581659659877,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06593696870673754,0.14154202509461564,0.9728992869406584,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036346397768576025,0.06060915679952909,0.5490320917850828,-0.08278066909524613,0.1554734646323982,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04271066681175329,0.11016505576207765,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008168141679247627,0.041336415522955014,0.8434501604509435,-0.08941470896282444,0.0730784256043292,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04895988852606292,0.04592337186981274,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012327200137411343,0.07794837757778464,0.8744162362443764,-0.14088003913088604,0.16553443940570872,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04337644235818581,0.12273399265532957,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03986105276225293,0.05988963008809193,0.5060395160531462,-0.07785178709050566,0.1575738926150115,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07867523040545968,0.14729866684088921,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04439769140124429,0.07302389252886052,0.5435160372885006,-0.09913049125794292,0.18792587406043149,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08605815659546538,0.17138770679032933,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005419218294661271,0.07239900381202265,0.9403671887669283,-0.13688074797142524,0.14771918456074778,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09171384809348518,0.10823472663575644,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09069670346148989,0.07433836253887408,0.22311368147194016,-0.05541506499631366,0.23680847191929344,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.019655874084939007,0.2025307592485694,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03849213985559654,0.07504857601055628,0.6082872156823307,-0.109015550476001,0.1859998301871941,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.029778931172068195,0.10776685583804006,0.9537283854402375,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052037256379507735,0.0683911303933431,0.4471474123583259,-0.08238524994586427,0.18645976270487974,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03346008447270349,0.13992588201613848,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0069517988901964915,0.07022187537155689,0.9211862892512548,-0.131069029717593,0.14497262749798595,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037568061337708895,0.08849208880768095,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02677861727214334,0.06219649253517825,0.6670122880234692,-0.09546835193484225,0.14902558647912895,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.01520228659727528,0.07100733180989854,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08486002643651933,0.14494063680923835,0.558531297878094,-0.36974029608899617,0.20002024321595754,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.34839252875547705,0.17251196634468705,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021080885732372854,0.054289618694106874,0.6979831187675927,-0.08562515305275223,0.12778692451749793,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0663447309874075,0.10662336500315665,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010520065372205007,0.053735135953464484,0.8448777526930011,-0.09509613969789543,0.11613627044230546,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06337400395186232,0.08109411166568259,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030087121680347398,0.07264459259168299,0.6789570246719463,-0.11269554839685415,0.17286979175754896,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04908646892019852,0.11470783985718078,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001035547254212401,0.04259466765688258,0.980615287134702,-0.08475520431506031,0.08268410980663551,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07561797695701226,0.0842775265860158,0.9985296925363316,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003576034600495171,0.06845954715217728,0.9583651186194099,-0.13098094460380508,0.1381330138047954,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04763473138978494,0.08221916940441588,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02389009592168728,0.07627140554296213,0.7542617465565243,-0.1260210611987949,0.17380125304216945,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05069105998834117,0.10642444818558539,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017063968501248142,0.05513525077700657,0.7570965317383221,-0.12543209392478308,0.0913041569222868,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037612836633387645,0.04178720702645469,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0038620556548311764,0.042767604967579476,0.9280882495878107,-0.08019750903157206,0.08792162034123442,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.040668028949742696,0.016390003967151744,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05085101556752474,0.05268825434597778,0.3350221625942791,-0.15440957882508402,0.052707547690034544,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0973458822273512,0.057806042022738764,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05535284643111653,0.06837791822476241,0.418667568124067,-0.07904369142722774,0.1897493842894608,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.043641291311050615,0.1421201412704979,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015136893367731703,0.09988824094709331,0.8796221762115541,-0.18119306379653655,0.21146685053199993,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07054054792775938,0.14822117408863442,0.9866385240592507,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03505920513346215,0.0650217389502103,0.5900334003444448,-0.09274077514251941,0.1628591854094437,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07576381995929911,0.15593136453921266,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00019873252821671957,0.06352823212505547,0.997505468211731,-0.1246657657708373,0.12506323082727072,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037968395323584876,0.06282724623026256,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027967770451864618,0.08643293310773173,0.7464150787916222,-0.141915830397719,0.1978513713014482,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07636931965496362,0.18083061800443215,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024439732475982325,0.04633024755828654,0.598110590468121,-0.11550165760635002,0.06662219265438536,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08744614988602627,0.07152815786830599,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05066809611080865,0.09258554400910693,0.584486022751745,-0.13130843803364795,0.23264463025526527,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06291308713915214,0.20923352121074562,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007189992148077136,0.07932484819456066,0.9278209743278727,-0.1631026791714576,0.14872269487530332,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04845699166997121,0.06721196986632932,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013162249086057298,0.04248791704295008,0.7568722091861286,-0.09667208822177299,0.07034759004965839,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06974860241904075,0.039324207010466926,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006722406792422568,0.04751054639571505,0.8875468029024612,-0.10010420479267203,0.08665939120782688,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09502683489444393,0.06249139572176367,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029796100219353056,0.044984801427025725,0.508095838677689,-0.11821355610276327,0.058621355664057156,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06977846330919424,-0.0024754441118335566,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03150326466634032,0.0557826333246816,0.5725380354951626,-0.14114381802182024,0.07813728868913962,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.11790874335884843,0.06285692361935483,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016775623048789115,0.04949644818863782,0.7348310785400757,-0.11406070345986288,0.08050945736228465,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05693529147486065,-0.0035063888643097688,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015790442145032245,0.04773172889032843,0.740944256817754,-0.10960697349608653,0.07802608920602205,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08152082547229318,0.0436607581818783,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01970644081817405,0.04265625385310487,0.6443275471734968,-0.10354714531315024,0.06413426367680214,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07155531843609375,0.016483283016105035,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016764649424957256,0.0486365348378924,0.7304940713041794,-0.1123595734200596,0.07883027457014509,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06486075586539698,0.042604988084802634,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01765216143839191,0.04096862928998812,0.6667786539409406,-0.09817584628175995,0.06287152340497613,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.061145881355829296,0.03457356197947699,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00539691510718845,0.049704286258560736,0.9135858947592131,-0.10309050045315925,0.09229667023878234,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05064223573959244,0.0358390978034904,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05551619339230479,0.043036709179561594,0.19775333444764587,-0.14010468138249468,0.0290722945978851,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06074278051000851,-0.012580058944039726,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00241197318157607,0.03712382338407929,0.9482272569971485,-0.07055476029639732,0.07537870665954946,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05748369642830498,0.04414699771184123,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07380435202424583,0.06124340947516415,0.22882799640406684,-0.19417804010652262,0.046569336058030944,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07966706182203279,-0.057721572349037756,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03626790412570511,0.06411222868090767,0.5718968664884936,-0.16228024543117736,0.08974443717976716,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0854381009856793,0.022427718741614346,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019556594550383444,0.03610407226896848,0.5883244677367563,-0.051405821994489065,0.09051901109525595,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04041230718737075,0.05658510424713249,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03348739107176477,0.050640044620043775,0.5087851256689027,-0.13302020591346148,0.06604542376993194,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08138225297337574,0.034172438386729134,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023610571136603767,0.051110904772501686,0.6443523626980845,-0.12406885981471918,0.07684771754151165,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.061060764326545565,0.023566144088035278,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05109344442066075,0.0412712079168902,0.21639435283670944,-0.1322118464028557,0.030024957561534192,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05381312622904552,-0.0003967950088804087,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019247685447928875,0.0350783015596173,0.5834917965854138,-0.049698582674288505,0.08819395357014626,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.02591483228718001,0.042475871942221674,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011066863305961839,0.06257238930488457,0.8596977341566265,-0.13405265618222917,0.11191892957030548,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.1351938790146345,0.14203444400584275,0.9840346955638503,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0017626775018515014,0.05268235902863038,0.9733244120848537,-0.10178429853191338,0.10530965353561637,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04506164258096404,0.05427905423223757,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005917917700251154,0.09383345310999536,0.9497661762263541,-0.17895252632026232,0.19078836172076463,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13737453396423377,0.1617022305071926,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024267925130423376,0.11685389275583641,0.835662184733217,-0.2544931840684402,0.2059573338075934,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09764921332807677,0.07349328991972934,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01964873287492081,0.11250109325807635,0.8615034118053836,-0.20200065094380498,0.2412981166936466,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.038949115686049925,0.06996598431676956,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06136455362818245,0.1642263192443803,0.7089981992756071,-0.38492285349138017,0.2621937462350153,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.19263411488742305,0.14833138671556134,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06225250998619726,0.1153989237783394,0.5900881674974945,-0.16510617256577698,0.28961119253817147,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1931036503198494,0.2508460738732498,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02327294666110551,0.13844212928551794,0.8666457487435741,-0.2960312973759287,0.24948540405371766,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.057109352837516274,0.04983082113575119,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04450297269487098,0.12231387269228658,0.7163056320490817,-0.19647952560437226,0.2854854709941142,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17360979824145986,0.2241779994615612,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03486213354239293,0.12665435804427314,0.7833649479541223,-0.214671978575705,0.2843962456604909,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13610436045379654,0.15905506367475974,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03972741859828551,0.11013206359445826,0.718631652223501,-0.17725450866528775,0.2567093458618588,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10750190004120429,0.14041816517873087,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00586291178804475,0.15630273346163165,0.9701105034951036,-0.3020843583907372,0.31381018196682675,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.18443041028772214,0.1986195373439214,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0345697424037651,0.10711015693630681,0.7471744467177895,-0.17645843161760233,0.2455979164251325,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12409346773076424,0.17360371625899892,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036692519851472545,0.1586396748759982,0.8172888295560687,-0.34924402639377644,0.27585898669083136,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.18537567147369818,0.15234721348656521,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059094615777107146,0.1364970382080446,0.665461035191486,-0.20983152116709727,0.3280207527213116,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12189713751642935,0.18556444653267518,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08549767914473147,0.13874322877958606,0.538344581438992,-0.18785389707035624,0.35884925535981915,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1268603238313463,0.1987907234580305,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14718623827753244,0.2426988790204966,0.5448022783037907,-0.6253509869967785,0.33097851044171367,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.031561153568527345,-0.1542832807374124,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.197657758787716,0.20237249304660235,0.3297293241751583,-0.5963715586859994,0.20105604111056743,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.04580864158156177,-0.23808414515857157,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05087342213885957,0.10457068949761296,0.627071465015744,-0.15515149923212704,0.2568983435098462,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07097370346591148,0.10704864357006288,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002800336779461953,0.1299159378558107,0.9828213852626888,-0.25315973205218106,0.25876040561110497,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1475280621966293,0.17052998980339387,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027244625354643556,0.09670971220954809,0.7784117112893139,-0.1632926174378285,0.21778186814711561,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10896553332308892,0.13951992388648166,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01939719732103639,0.10700439666898333,0.8563094988109758,-0.23021700271765652,0.19142260807558373,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09304023901426366,0.0877415008623044,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13846087408829633,0.1590726344907682,0.38496379907225065,-0.17494364844747906,0.4518653966240717,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07176035036031649,0.20627773583782316,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054203509820942346,0.12155826343802675,0.6560795098461241,-0.29369730858168225,0.18529028893979757,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1359770681870868,0.10483025765494339,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004424064368244797,0.09257486784501964,0.9619253054376702,-0.18681484672160226,0.17796671798511265,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.01192651755953885,-0.018924330163049105,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17483363543401367,0.16275178705662718,0.2838286600501833,-0.49548681552129414,0.14581954465326677,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.19394030519739516,0.022189980080795424,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02393033151850721,0.11054583818479585,0.8288074752413449,-0.19386681344946458,0.241727476486479,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10721086321611087,0.1290870910528738,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017036448236343364,0.10400305316966986,0.8700249297471447,-0.18787011740424076,0.2219430138769275,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1575858079173237,0.18725108817508923,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018517232683131362,0.08994323045835466,0.837066845763114,-0.19572316937591794,0.15868870400965523,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.022594098891166096,0.002024676786988297,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003143773286073171,0.11612121741818845,0.9784245211998409,-0.22563797046088402,0.23192551703303038,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17071008558191356,0.19778549144101193,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03028558768421215,0.11353835510434754,0.7899027893986308,-0.1934074069335418,0.2539785823019661,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0746513162609289,0.10059504437249199,0.9728992869406584,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03263113625830438,0.10908546698867295,0.7651046971018653,-0.24755106140206776,0.182288788885459,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1635307376502557,0.1414908344431012,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07746236172443749,0.1425489272952363,0.5873677824156698,-0.2033871925685936,0.3583119160174686,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13103732931426562,0.18798204656815223,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04442537956824188,0.11730141138228815,0.7052344070428475,-0.18668157949310515,0.2755323386295889,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12361507083166484,0.16610119885145117,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05066670652414461,0.1353318530084027,0.7084557030423841,-0.3172971983856575,0.21596378533736826,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15897242244553303,0.11530241755235521,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07782737439588748,0.13439413556647795,0.5630824747007879,-0.18695562881303157,0.34261037760480656,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.05976742905122966,0.1388080016398195,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053921195434904395,0.14613845544725082,0.7124826531169773,-0.23400043860466616,0.341842829474475,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10050256373341253,0.14603846136522047,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0641905914428453,0.08563048759499489,0.45423793085181374,-0.2328995725012592,0.1045183896155686,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.19821096848973516,0.15868706926747267,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03205428519976219,0.13293214490409078,0.809664338174623,-0.22984830751640298,0.29395687791592734,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11135602311913384,0.1331095699083396,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05674571962131699,0.10591771556143428,0.5926403965374538,-0.2654245485089963,0.15193310926636236,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.23080773111711425,0.20709435135125082,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022297744672326633,0.08308149629444263,0.788641215480953,-0.14138921984594005,0.18598470919059334,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07114910715837043,0.08864884343179981,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08594582836921283,0.1206613435853715,0.476998055208548,-0.15178086105135588,0.32367251778978157,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13545790901570312,0.21383441704452355,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04786034463580713,0.09139270729741938,0.6010002912491315,-0.1322013478450695,0.22792203711668377,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07360463628121698,0.12172050078482978,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005320595832088492,0.1358451393177171,0.9687910795065676,-0.26232117148362055,0.27296236314779754,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11571867372203373,0.11064667686763086,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07688968352060116,0.11143789537320739,0.49089474868603555,-0.14266499037812427,0.2964443574193266,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10585078445138488,0.1777441802796172,0.9419198731133068,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09231131782918373,0.1454192577775686,0.5261854043032405,-0.194193354688393,0.37881599034676045,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14900970238803604,0.21902034978572793,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07401566853297217,0.09397815404494247,0.43174065773359527,-0.11113986492214303,0.2591712019880874,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07774659284945128,0.15374030126348892,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051053274081829955,0.11381359831871422,0.6541593338797894,-0.17318200405600243,0.27528855221966236,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09282055437228111,0.1363273779118166,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0536796510342665,0.13736211310809734,0.6963100243745406,-0.21695085440095233,0.32431015646948536,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11481152927345065,0.1564111010271336,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06969071145780965,0.09432970320329344,0.4607724860514094,-0.11615744330500906,0.2555388662206284,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0554121781007708,0.11855740268456458,0.9368883182059652,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05023104733175953,0.088308319814336,0.5700299333243037,-0.12375379233564862,0.2242158869991677,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0893959013148645,0.12509637901221035,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03411743927998183,0.13010990324026953,0.7933833959845626,-0.22222477968640553,0.2904596582463692,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11688081953477263,0.15043604975419145,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007093431744466947,0.07143769300165954,0.9209891353458105,-0.1336529394834626,0.1478398029723965,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.07395601013787523,-0.09484609918517525,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02039927125902321,0.0897149690797677,0.8203286836379862,-0.15635694541373343,0.19715548793177987,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.2347225094020851,0.26794689929784954,0.9788034269246562,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009178495690941051,0.1496428752358743,0.9511441990946206,-0.2856475378019635,0.3040045291838456,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07828874747483454,0.10066790196430463,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04523273985814538,0.10880628093321189,0.6779989094847417,-0.25960261330577306,0.1691371335894823,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12906158165922987,0.11544839432494608,0.9620942694833536,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07953371261872347,0.15581445320262197,0.6102274484762125,-0.22745154896613248,0.3865189742035794,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14683363892364742,0.23220759414520212,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0761790167691694,0.20933956344338078,0.7162614280027129,-0.33626128849671205,0.4886193220350508,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.24152986927548362,0.30012949926224963,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06331453319309276,0.12769527160676677,0.6204850972939413,-0.18827038432656695,0.3148994507127525,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08871555063038614,0.14199970991371222,0.9580596405456464,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00333989667170603,0.18292824504039992,0.9854486893328885,-0.35706489249095186,0.3637446858343639,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.20790298237976382,0.2414654529036338,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03628197014813473,0.13836193718923154,0.7933796049526266,-0.23631838629112856,0.308882326587398,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12413923951942907,0.14948495957616936,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10300515976924264,0.13548211225437887,0.44785225727194244,-0.16392137249791577,0.369931692036401,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11551623911237478,0.2072205089403848,0.9330843092453226,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03711599898386342,0.08683359521346809,0.6694549157863925,-0.13396334181577066,0.2081953397834975,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10830737865723522,0.13307538879652545,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015433791701803616,0.09015675914323856,0.864224198267512,-0.19306042209686,0.16219283869325277,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.010104967779702566,-0.007825290810444446,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0581810457028321,0.12894272392527772,0.6522534001286477,-0.19586159937958925,0.31222369078525347,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13652364708484405,0.17543291245308115,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006890925571907876,0.13883660349916177,0.960457091182685,-0.2666446172914925,0.28042646843530833,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12457476937809495,0.1496566445453615,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047073741672814154,0.10388737691457219,0.6508819776390999,-0.15760491888771855,0.25175240223334683,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08721489941768454,0.1368055910159839,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03054469018449713,0.0815821321765449,0.7084441586787751,-0.13018823074870353,0.19127761111769778,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11781143586200163,0.14929294199059545,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10989849341450293,0.10555474756997638,0.29888431869689397,-0.09806521680790255,0.3178622036369084,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10156254916133518,0.21310721250755105,0.8861144350754685,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031561762148901565,0.1271086136598613,0.8041167846028778,-0.21886732329234748,0.2819908475901506,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.18061519673230222,0.21511496536496563,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07345250305634458,0.10057551549779363,0.4659271043342973,-0.1247011360927248,0.27160614220541396,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12408080829265108,0.1865549541325171,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009226790742396969,0.06825302689243111,0.8925822562280906,-0.12524515896360497,0.1436987404483989,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1335277260882628,0.14214716582880416,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12878747029417317,0.12516542861297617,0.30457572710510605,-0.11781315663334552,0.37538809722169186,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14902183439504213,0.2766823588377063,0.8924777119824038,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08300546957617529,0.12938289579425294,0.521796644359953,-0.17190440106563581,0.33791534021798636,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.16759347834904717,0.24166666713563115,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09605103164351311,0.10673414581450137,0.3690977444639246,-0.11423632616848667,0.3063383894555129,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10848883260797962,0.19090509535554873,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05679783336468494,0.19893969423968463,0.7755126233636341,-0.44874834129582697,0.33515267456645714,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12629494707662947,0.0821932380258745,0.969910068419809,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008823122933859204,0.08664283533972585,0.9189766004342554,-0.1618803832205478,0.1795266290882662,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1161836042757258,0.11642566327985909,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03762876103893414,0.17117919889281588,0.8262031275739521,-0.37488560769141716,0.29962808561354887,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1738013969207001,0.1294105196122738,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0671239207109932,0.1248560112013046,0.5913589685078955,-0.1788670927749702,0.31311493419695663,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10600368068996295,0.15962105481452876,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10765364450119742,0.12959889752461823,0.40701162146384817,-0.14768179223115308,0.3629890812335479,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1512689696441167,0.25503821159912254,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0006614247589190748,0.12360699904490083,0.9957350947691068,-0.24419163749324965,0.24286878797541148,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09654752844061942,0.07596489303907154,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06609605582464048,0.08985597911798424,0.4627275310194815,-0.11093797848684125,0.24313009013612222,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07249610926107662,0.14267427612045738,0.9372623478521674,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07758429072800715,0.12328040228590555,0.5297483469539239,-0.16530246185591904,0.3204710433119333,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12761098875843743,0.20143115702733225,0.9454007145054515,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0892869884024979,0.12442660953401165,0.4737304358935065,-0.15585801894957063,0.3344319957545664,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08070305366894963,0.13116162187464417,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11281034609526808,0.11895922585208552,0.34395365031688707,-0.12156283505401386,0.34718352724455004,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10477950590310994,0.21285699392385748,0.9053547642872083,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10752156296791154,0.12341542564708592,0.3845326877917322,-0.13563121231801728,0.35067433825384037,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07938459551656585,0.16160357019993019,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05146198021435187,0.11563074577554763,0.6566935657466719,-0.1763534374799108,0.27927739790861456,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08806588098574623,0.14578396566747642,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04765812384806785,0.09002059634881066,0.5970226372195672,-0.12970023893633742,0.22501648663247314,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10883304716818505,0.16500087092242335,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2021657564107531,0.1556801044944103,0.1953659409031994,-0.10455481167175931,0.5088863244932655,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08120979999534107,0.27272385440234154,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011834920803005848,0.11096734477037261,0.9151566081256102,-0.2067926754278199,0.2304625170338316,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12181984608304104,0.16064939949421464,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06261610854769989,0.13517040926365873,0.6436259716168389,-0.20369630723554943,0.3289285243309492,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14916821207662712,0.21240880252522182,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03453300473506334,0.11460041296434562,0.7634285417163087,-0.19125245372842758,0.2603184631985543,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0513179351242038,0.07970321679693687,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07340766566104898,0.15949910822958288,0.6457740900483858,-0.2408370944109635,0.38765242573306147,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11122529822097921,0.18594725796569928,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12041507163710781,0.13295023339921713,0.36602213776635173,-0.14152315898872436,0.38235330226293995,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12005870850319067,0.22716933638405057,0.914684777397777,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001275046388931256,0.10351326069159081,0.9901826777034289,-0.20266653128734727,0.20521662406520977,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09916252438847581,0.11189630045464825,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10797143339784991,0.11424432732324805,0.3455907769771769,-0.1171124659905224,0.33305533278622224,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13956247690784518,0.24851787386928045,0.9073272983575541,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006456805953792834,0.1519966423357165,0.9661524950467195,-0.3059202257353445,0.29300661382775883,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14930251115431942,0.15354551413769518,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007539370127529923,0.07151111854912222,0.9915971328953612,-0.14164497107799667,0.14013709705249067,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11680908605390083,0.13197928132529424,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006559591495409534,0.09677368774733167,0.9460166662880933,-0.1972228787388157,0.18410369574799665,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.05436096889290219,0.06463739935278584,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08226348854096804,0.14639619889665456,0.5747081675184988,-0.20616595102376833,0.3706929281057044,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15419602409269967,0.23657624998556656,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008400033596177912,0.10551590706087464,0.9366164344332696,-0.19948715314845253,0.21628722034080836,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11792925354679326,0.1382570103031585,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014332528476505122,0.06665999703286012,0.829948033999472,-0.1170008376250802,0.14566589457809045,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10221172380354694,0.11096900445520207,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1196106252064165,0.11365583368126474,0.2937093705997941,-0.10431382542151033,0.3435350758343433,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1425425587192603,0.2464000683714086,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04969452986727833,0.087653596691254,0.5712991565673861,-0.12300037587504259,0.22238943560959923,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.044322362210319884,0.09430284849867357,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035036429097670733,0.08318492907073066,0.6740066419271273,-0.1288543184280936,0.1989271766234351,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10299743835438734,0.1156175393054435,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05240733292300884,0.11147867739490237,0.6387155540014905,-0.2720423554629589,0.16722768961694123,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.02176546104652432,-0.06810390956193904,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06669024936440893,0.08599259113326226,0.43881011019616245,-0.10273214721567842,0.23611264594449627,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11364336962682518,0.16260003812185622,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054756079788827156,0.1294808126850834,0.672765894574849,-0.30985886605385116,0.20034670647619687,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.00037866641469055685,-0.0431073058960067,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037554402965836974,0.08419581899249139,0.6559851343701499,-0.12832799745660478,0.20343680338827874,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11018871220410457,0.121087978573437,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07017369241045833,0.12785289768463315,0.5836252158280294,-0.3220691644502657,0.181721779629349,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.015610388819573714,-0.07386239467393874,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049142001885241315,0.11345706298008902,0.6653188130999668,-0.17439083118448323,0.27267483495496586,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07041816827684634,0.09409969790251879,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08917603766981298,0.06862441670639526,0.19506360633878095,-0.046027623355943556,0.2243796986955695,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07202792821433489,0.12982747012323098,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0534954324484584,0.10632139387516623,0.6153352798744258,-0.1559787224836925,0.26296958738060927,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10564504090223022,0.1582000829033467,0.9560640930990785,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06318109752147633,0.11460213724127119,0.5819507116007647,-0.16260775810827335,0.288969953151226,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1410949341307098,0.1923941424540837,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09451628831758783,0.14329362556661185,0.5101628159288423,-0.1878004687216655,0.3768330453568412,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15531219321825057,0.2693842436132915,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03202260295410491,0.09293433128696271,0.7307266862584135,-0.21512159931769664,0.1510763934094868,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17425115653778928,0.14297990558866042,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002181099065569776,0.0576903545375497,0.9698739376643102,-0.11584249705926218,0.11148029892812263,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09186783746398408,0.09247239913296755,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06465398221532076,0.1047440549673911,0.537668078678371,-0.1417125033879673,0.2710204678186088,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11446483034006621,0.18079423065325662,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08786305273092308,0.10668037478566862,0.41100325259132964,-0.1223183655291762,0.2980444709910224,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17886866296189452,0.2530291977443315,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07233617147830103,0.13001106578927604,0.5784818258568127,-0.1838113181794505,0.32848366113605254,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13272062974431928,0.20289708553421074,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017875601676741473,0.10180645446326583,0.8607731380555088,-0.18270323046658166,0.21845443382006458,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11721416786177222,0.12288598555681027,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10657839625634304,0.11548503785229754,0.35702638033489376,-0.12094994803738117,0.3341067405500672,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13248237331126367,0.22904216851711373,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02103834040314115,0.10378856551451683,0.8395434172906485,-0.18344564217425147,0.22552232298053376,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.06018191366046278,0.08528635879586549,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02593137752142856,0.16066398537907692,0.8719171994423933,-0.34247117575647085,0.29060842071361376,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.20070977416667907,0.17622949614798755,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04187565494140483,0.10933263136907573,0.702060432291371,-0.17353123287117936,0.257282542753989,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.154677280168388,0.22216312274875638,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15583635839273446,0.17519239103842155,0.3746435245129446,-0.5009999865747008,0.18932726978923192,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13484644821455202,-0.03587287741614728,0.9159127256227925,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019863780056372984,0.10959894961555816,0.8563362823744451,-0.1960678073259932,0.23579536743873916,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11763785285898316,0.15987680074358063,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04359917988060625,0.1450923454976163,0.7640693643274389,-0.32945977060914666,0.24226141084793418,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1543432624919067,0.11785013086203838,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09928051072657423,0.11597764697334872,0.39285986688640373,-0.12921837087467647,0.32777939232782494,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1456456932825738,0.235192423493431,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025476401401862768,0.09190548016570907,0.7818706249388615,-0.20654835775666147,0.15559555495293592,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.02652172468869608,-0.04998578515972886,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1784559261082214,0.23261903309631607,0.44376327978308316,-0.2798495343732019,0.6367613865896448,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.22715407841522944,0.3400261482773094,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008590320837306258,0.11313776046558117,0.9395415548990245,-0.2143134231849894,0.23149406485960192,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10454293014266551,0.10700084738796299,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06412101509171933,0.16893673376386636,0.7046204496640345,-0.39695976233136876,0.26871773214793016,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.21282600065998966,0.16432550734910012,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02385385806923892,0.07712201675128866,0.7573695626433753,-0.17579947030046417,0.12809175416198632,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.06175086496294489,-0.09019314070152719,0.9659382371888035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09440695216374465,0.10524402526129695,0.370629298199209,-0.11294457371215377,0.30175847803964306,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08443310443233173,0.16574517015642443,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010307078982780939,0.10427743244667734,0.9213480263415375,-0.19514006805057085,0.21575422601613273,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10449863363230495,0.13165266767627878,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1091627600993081,0.12563212436855056,0.3857915910742675,-0.13835734968529345,0.3566828698839096,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07169364171373561,0.16230879424965478,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0072361613022060714,0.10211933208973704,0.9435700741304651,-0.1939591015895625,0.20843142419397467,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.113116656094649,0.14217911185354215,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10003627261373599,0.12014393603936029,0.40590217715746635,-0.13667102170199172,0.3367435669294637,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13098784126384982,0.20376008045429658,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10209678426317448,0.1184603210697506,0.38964803468361264,-0.13129345588183583,0.3354870244081848,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1331257252813677,0.22915118881031651,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03544072554524868,0.13944489992086226,0.7995993699805496,-0.239293281467649,0.31017473255814637,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1492609257884399,0.1959018594751898,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09614930240549098,0.12154753297209354,0.4297234760520915,-0.1433233552170315,0.3356219600280135,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10482812971759342,0.2029995552077733,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03719237605311729,0.0731502890986791,0.6116273632788654,-0.10692814789316807,0.18131289999940264,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07098520187084767,0.10243280337988153,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013490120955337827,0.12649875340100317,0.9151645021341707,-0.2357374192682008,0.26271766117887646,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12487772411507429,0.14810895591751655,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07112425228655898,0.09920195795602044,0.47411427246734383,-0.12432320709165971,0.26657171166477767,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13345241896432558,0.2023306522094362,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04249436536808487,0.10573146242911337,0.6881198395864886,-0.1658175080454949,0.25080623878166464,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0841256708098753,0.12921348660795223,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03654595446850296,0.1437162214333023,0.7994938845368986,-0.2466033999326392,0.3196953088696451,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.20275041873132116,0.24979384509138455,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0825053686080803,0.10176555786764555,0.41834255131869846,-0.28300362637690624,0.11799288916074563,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.011026956922275557,-0.11024272640224897,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04082687398647811,0.09756943078550268,0.6760114578547102,-0.23305793225308705,0.15140418428013083,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10011664162089873,0.0674762795047555,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04665885503247167,0.08971217901665011,0.6034911653881972,-0.13009186466462974,0.22340957472957307,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08170779602222242,0.15196574988546063,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0514723222324165,0.1347879592508246,0.7029011936906353,-0.31703123591865345,0.21408659145382047,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13923468496630748,0.09742401789060404,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013841801860852602,0.1004888128422477,0.8905611477952792,-0.21182461964614094,0.18414101592443574,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.004864213827505042,-0.013443540094048839,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1160880284370241,0.30052725063127383,0.6996409218281849,-0.47601003918220436,0.7081860960562525,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.43337977816193474,0.6067621227976956,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09244798723725449,0.12145713514739694,0.4473327625401905,-0.1468465688080985,0.33174254328260744,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.169621272071354,0.27185006579600896,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09933725802694758,0.11395114704442023,0.3842405010059369,-0.12516901828001237,0.32384353433390756,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1728847900135688,0.2792194642892617,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01005630434931987,0.10903224786435949,0.9265926583372084,-0.2248713773021415,0.20475876860350176,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.055221215626040356,0.0439998119458457,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10485502826423036,0.1120361067762336,0.3502916674583012,-0.11587824030441464,0.3255882968328754,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14988548637086804,0.24994175346095326,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022891997585772546,0.10850329949241073,0.8330874872617235,-0.1908809425546558,0.23666493772620087,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.061277367786281386,0.07159304171363032,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017406096157001408,0.11328299557725584,0.8780175633473208,-0.205783789733602,0.24059598204760485,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.06592879888797362,0.08071503614948033,0.986092730312823,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1315789473330392,0.153905788515795,0.393467138454623,-0.17164586766858864,0.43480376233466705,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09346277263960959,0.22243719955982044,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04601399282865017,0.1305063565062295,0.7247217049587412,-0.2111093174104359,0.30313730306773623,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11731008913613851,0.1346342267325381,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062328673417965164,0.12376808070572917,0.6150235631790757,-0.1815189020177677,0.30617624885369804,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1596024796759891,0.21734575972755454,0.9559539934434115,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053236376859171604,0.11984762287069768,0.6573098906338137,-0.2893598756814566,0.1828871219631134,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.04488900314586509,-0.0031038812055861342,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08705814950591073,0.12546837407350386,0.4884578703797854,-0.16013933984055895,0.3342556388523804,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1728630598663154,0.27418811273308347,0.9404802865694325,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016116777745498,0.10666502365600865,0.8800298392588515,-0.2262679512467997,0.1940343957558037,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10282974278543645,0.08171710941098825,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03751540966451506,0.11010829616504472,0.7336260982072029,-0.254450510395724,0.17941969106669392,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13739015207163546,0.0929771883489372,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03432088151515717,0.1323325790246986,0.7955917139251621,-0.22640044794500436,0.2950422109753187,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15171574431986093,0.191109589395095,0.9735235918682278,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033078697971062165,0.10958128136212864,0.7630246238506747,-0.18281807946081913,0.24897547540294346,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.16552433843684686,0.20331650425920766,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1815427798404023,0.08839963695629925,0.04112501764514261,-0.3557075323216514,-0.007378027359153189,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.007200603102621889,-0.19051979078869782,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11665050078716505,0.18186286766172124,0.5218802209814171,-0.2416552844220216,0.4749562859963517,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15576777115940987,0.2621222011293477,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04408478705295735,0.11898868907730699,0.7113498361445728,-0.19034644247191387,0.27851601657782854,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11127857239899097,0.13487225540107622,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09977144245017873,0.1095038422497947,0.3631723422677705,-0.11597276462851579,0.31551564952887323,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11436212185412727,0.20882904417049308,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0782552893722669,0.13263525114077757,0.5557599043124879,-0.183062363964269,0.3395729427088028,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12880891887699017,0.15456384786088054,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1009221112441573,0.10984189271213396,0.35915330192045924,-0.1154881220437692,0.3173323445320838,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10392550901625104,0.2083091642053818,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0243311533301164,0.1388106223254756,0.8610094349966124,-0.2978155081475019,0.24915320148726913,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11733543681739042,0.02746209967342969,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09715434470277541,0.09869871591293838,0.3259631808951865,-0.09730162841046154,0.2916103178160124,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11035471015423341,0.19680094326883996,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08321364475267835,0.13183634584925794,0.5285356772896261,-0.1765300072967,0.34295729680205667,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1310845705678187,0.17335337705374088,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09356291616422534,0.10537350079359939,0.3755010942837881,-0.11404370209454089,0.30116953442299155,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08712577423712817,0.15908028498923732,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03345815069928345,0.10026846015907384,0.73891685371526,-0.16409052875868882,0.23100683015725573,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09364123437384171,0.1126064338882028,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07530440541356674,0.11934645999991574,0.5286765591931893,-0.15983170352401005,0.3104405143511435,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12110431170206701,0.1807413641047018,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016690316112273486,0.08472564029640157,0.8440051309733123,-0.15023593697101606,0.18361656919556302,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09241123322454396,0.10354974592296712,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11206594719710103,0.09887151065305676,0.2581900865037848,-0.08273046569823203,0.30686236009243406,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10317462730477192,0.2144248976520381,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12325802797012071,0.20211654150652728,0.5425644394124212,-0.27495149681845377,0.5214675527586952,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1593858607011699,0.20861618589239503,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.145337609143034,0.09616788564902447,0.13206949446043176,-0.04413212826083546,0.3348073465469035,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.05932143872550823,0.1948083693352913,0.7380396089280018,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03942182494011781,0.10859943123694923,0.7169323850943901,-0.1745405137325852,0.2533841636128208,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07940518742604119,0.11316752169601911,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10815440331057964,0.10179310878030108,0.2891121894250055,-0.09239813520020969,0.308706941821369,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09208005527654003,0.18099117325814562,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02599178597950798,0.1043626307810295,0.8035394833655202,-0.17962321860762082,0.2316067905666368,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09822384660000448,0.12009188858032474,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11400787774777764,0.11129448874023286,0.3067180417566936,-0.1052642567469848,0.33328001224254006,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07794943197768685,0.1823809872785036,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02921341377515896,0.11043568534946055,0.7916063599560725,-0.18836670834111532,0.24679353589143324,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07086319401651975,0.08521235333609119,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.116129014913634,0.11839176515969385,0.3276655593950888,-0.11712615654198719,0.34938418636925517,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.22312977982467389,0.3868177646430907,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01550287247407356,0.09377585928925924,0.8688367430786832,-0.20025984528725715,0.16925410033911004,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.01843252351555352,-0.03472640323813575,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10666210632901821,0.1287132706448947,0.4078016496928364,-0.1464109906108401,0.35973520326887654,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13100498282172565,0.2581990419764447,0.9246299615143487,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024511179421869568,0.09708488263988738,0.8008119709015431,-0.16637490242981176,0.21539726127355088,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10533388712827474,0.12726622588577502,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020423355317815486,0.06903678133786112,0.7675179785825523,-0.15616190013448633,0.11531518949885537,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06580482308437137,0.05594406049527558,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12442985575891578,0.10714792076134524,0.2462470468383389,-0.08624194212081372,0.3351016536386453,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15180902948419334,0.2777352916390648,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.116255290452054,0.08430781357615827,0.16871847215053015,-0.0495088096368196,0.2820193905409276,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14866488538579417,0.22960783697753995,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05616921833755086,0.086393238754378,0.5159802257013166,-0.22603363384568273,0.11369519717058099,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09046983131592606,0.047074704946553594,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06743204317934298,0.09322724158498633,0.4699319552358505,-0.11586923281856157,0.2507333191772475,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13762105910573605,0.1868728199880079,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0017961213568235537,0.085341988966604,0.9832197915098548,-0.16600135079638945,0.16959359351003656,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1305916220999796,0.1085818870034497,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014821680563444779,0.06619367546242053,0.8229437319924143,-0.11532681432892018,0.14497017545580973,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09069419475341021,0.08570894091646866,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10922214088896447,0.12016711858984383,0.3639646295952391,-0.127047706808183,0.3454919885861119,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13731405438058453,0.23087129498187775,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02273997434183584,0.06911785139991797,0.7423333151371587,-0.11315796858173602,0.15863791726540769,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12573676621859914,0.16649491796790852,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06695724226912994,0.10629475810944165,0.5291222400063775,-0.14203708666408865,0.27595157120234853,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13777736056177423,0.18249336629266522,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06374707621945808,0.07573731145339133,0.4004886564766681,-0.0851658980789585,0.21266005051787465,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11173972466384563,0.17680004745121272,0.9219399112464703,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027454149660671442,0.0761756032150356,0.7187421659586064,-0.12232058390255751,0.1772288832239004,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.110814948963156,0.11096760808291983,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0835812952704835,0.12577512275335254,0.5067512842199524,-0.3308774728417764,0.16371488230080938,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.00982262051779768,-0.06880574336040605,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013089063286198362,0.13691828536038575,0.9238901471953391,-0.2561165464402798,0.2822946730126765,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.03089412684655002,0.03409879723306335,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04194617517105211,0.06366138447643824,0.5103590469740369,-0.08322338694332859,0.16711573728543283,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05587595956102646,0.0653327278478842,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03758522607994836,0.07129033732764348,0.5983505990763462,-0.10258420912280414,0.17775466128270084,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13610904066166563,0.18614102025323892,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044854387699486686,0.06677502887014639,0.5021643991047553,-0.08643715100314414,0.17614592640211751,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08872515577754538,0.12681868898125814,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04302499430051792,0.07254348890983338,0.5534693421304622,-0.0996083589601855,0.18565834756122135,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09377109428103265,0.15319706695444293,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09955918913367734,0.11163330930291844,0.3730379838894323,-0.11993167738992325,0.31905005565727795,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08612828913043083,0.1750846056901294,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021063969710753992,0.08442303954788724,0.803103939333192,-0.14492668505556078,0.18705462447706878,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1300438965757556,0.1695130438701191,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03733942348236168,0.0669715777506889,0.5774833254458271,-0.1690174121108606,0.09433856514613723,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.026528246586891284,-0.006823016431873371,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08014224510143284,0.10574907832054065,0.44900508897232905,-0.12777918067717897,0.28806367088004464,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.16265571816985272,0.2238235296959699,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02976165693192759,0.06996136729510864,0.6707830770468608,-0.1077947877051377,0.16731810156899288,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10468165337871653,0.125703109117972,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027372054736005593,0.06295884374216866,0.663980714953949,-0.09641618781080295,0.15116029728281413,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13711289792345482,0.16765675237797464,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008863708418506916,0.059481440655269266,0.8816191460512648,-0.12581476033143144,0.1080873434944176,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.054442229154568825,0.042957624769452814,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00871362102752823,0.062210490275537385,0.8886808824314159,-0.11360322600227449,0.13103046805733096,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15089291932755758,0.18035132971540593,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015577906827006854,0.0734084385654874,0.8320571343687211,-0.12875609071813354,0.15991190437214725,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08595756340881922,0.09440587138369515,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03546595319691814,0.054158581904308355,0.5129549686815326,-0.0710194152481725,0.1419513216420088,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1307117244307673,0.16385962970754425,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020151223046193364,0.06069937995241957,0.7400829401469017,-0.09919451333298909,0.13949695942537582,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11621751257900112,0.10843385382543058,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011495221348707183,0.09974865231506834,0.9083138052980303,-0.18462830368078267,0.20761874637819702,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11124881198280456,0.10377399792493892,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029174949483979286,0.09031883738409727,0.7468550461817645,-0.14840788851150255,0.2067577874794611,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13387447538674233,0.14831332783014403,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028750693876602066,0.07633838297410146,0.706663297532621,-0.12134409353608253,0.17884548128928665,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06436495030409303,0.09373001677582056,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08962369183586642,0.09625206371810294,0.35237013991554667,-0.0996249204474471,0.27887230411917996,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08962071115610927,0.15850364571393544,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049370986579927105,0.07358464440955521,0.5026622521916888,-0.19405143603662037,0.09530946287676614,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14896379419539713,0.10613431804984205,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02464321126001007,0.08324959429374516,0.7673783022745035,-0.13904024221255146,0.1883266647325716,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11558936474441588,0.12188297262230069,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00907060694214376,0.036481991926243046,0.803778372206081,-0.08080066735511358,0.06265945347082606,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1756073488517283,0.18689110270010573,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014024560482307569,0.04840460309166461,0.7721749309830368,-0.08114746606302271,0.10919658702763786,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07078637721955149,0.06063612764525479,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05678366319880876,0.049478336565106786,0.25183068191191454,-0.04049951361137405,0.15406684000899157,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11198853374084222,0.1390465309106338,0.8597986894695818,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027245228740154146,0.0596753379756713,0.6482478691324183,-0.0900870596615693,0.14457751714187758,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07671333724132322,0.08516345365367649,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04590393311209043,0.059818417493962564,0.44332369334948873,-0.07170967497501751,0.16351754119919837,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09257265980273846,0.11285538088583712,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03141339809894413,0.06528146469037652,0.6306496186512388,-0.09694152877990975,0.15976832497779803,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08909969497795459,0.09937780713288458,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03199982310719719,0.05858236860230392,0.5852214804481849,-0.08318349384198961,0.147183140056384,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12278727762321157,0.11636786331776175,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028215107446272293,0.04827849818038391,0.5592792408641429,-0.06670897449880633,0.12313918939135093,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06540827420712515,0.08516101231372727,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0070689749101870165,0.055454034727070126,0.89863176184399,-0.1161014331475982,0.10196348332722417,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07924335267943859,0.046167788306200636,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047681382153481514,0.06610159133240807,0.471143609584008,-0.08228605902278639,0.1776488233297494,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08680618842708336,0.10150379801659432,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01769462031424093,0.04445826576134269,0.6908481175776249,-0.10510744841212229,0.06971820778364042,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04778802368009805,0.012992619702787806,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012001896599636366,0.04612320988140657,0.7948386790549586,-0.10268829985092082,0.07868450665164808,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06722661664890746,0.024340117194424037,0.9733769568556405,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0028961656058265166,0.06705910157530003,0.9655739737311844,-0.13474624158195772,0.1289539103703047,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10974767980425738,0.09443005558274939,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0939620673722372,0.09616247010009432,0.32912756873179494,-0.09511038798287552,0.2830345227273499,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,-0.06496599857441104,-0.0036072669095568014,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017888722192788493,0.074063016504295,0.8092706801688708,-0.1635097359510401,0.1277322915654631,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.21701290718529914,0.19644227066885103,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018146486925442386,0.10217253001954497,0.8591260546806976,-0.18274281116071797,0.21903578501160273,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09465424621428625,0.11467566709094351,0.9839478606341621,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04041687318006179,0.08908712567995866,0.650317520737834,-0.2155779477167981,0.13474420135667453,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12789104453041117,0.13258319332503274,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0614908698812242,0.08469867169640034,0.46828482358103574,-0.10504172652864374,0.22802346629109216,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11651796529762513,0.1640957332932653,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09110130820261136,0.10132026546796565,0.3691419569245199,-0.10811228676141099,0.2903149031666337,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.17679763394290599,0.21980027804264193,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004575524463195579,0.08259873195864892,0.955852975496194,-0.15782821833152336,0.16697926725791454,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09762116874807383,0.0735908108337199,0.9953510323348796,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009971548173604855,0.10500655427045782,0.9243953093288273,-0.1964899437538564,0.2164330401010661,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15664319531548127,0.1846406540601642,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09048405488752115,0.08052693123974022,0.2618655000632715,-0.06784616058907861,0.2488142703641209,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10614627632584199,0.16611993265263328,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01857698541097939,0.0711389467152559,0.7941274974874399,-0.12129478902274297,0.15844875984470175,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09345942192894832,0.09096012523147828,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02286464231991075,0.052876041906675046,0.6656797684647326,-0.1268283098749217,0.0810990252351002,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10583853846352176,0.05371654561337127,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02348443935265031,0.0691942311412668,0.7344953440305169,-0.11256367967622731,0.15953255838152794,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.023607097830419352,0.046065199702345724,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038536056136577214,0.08103942005076206,0.6346857900065157,-0.12080180315097147,0.19787391542412588,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11907368345225727,0.11756774964505433,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05126963638046806,0.09583562835496409,0.5929778046057699,-0.13716019019025508,0.23969946295119118,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10993603372003416,0.1704320243584924,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048476737936604855,0.08168425003833792,0.5532203491571543,-0.11212897136468274,0.20908244723789243,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09075634083066547,0.13388163070522507,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03233972552078259,0.06400563012421981,0.6136642148820056,-0.09350668453441768,0.15818613557598288,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11300215047123048,0.13450237746347435,0.9555250172093686,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07807334724881967,0.08790952767033419,0.3750388770139904,-0.09477236094105349,0.25091905543869286,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08347158016861092,0.1477647801190663,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002669766403423342,0.08182999572709788,0.9739900167548803,-0.16356203755365872,0.15822250474681204,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.17750257568213562,0.16908821862758894,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04578880331461801,0.06198544549390833,0.4605401017670788,-0.07608556579855913,0.16766317242779513,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11360130080564586,0.132477934878582,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02050530946862417,0.06536143216244586,0.7539030963327555,-0.10800684762984611,0.14901746656709444,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12646760512727695,0.12638538441443622,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043418454281944914,0.05398697301991738,0.42175759476241037,-0.0627295006888581,0.14956640925274792,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10267402524143662,0.1272115974498125,0.9282753503874777,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0487833088801416,0.06474097523821906,0.45160333644756956,-0.07850891996582504,0.17607553772610823,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12075833058684607,0.14103516257459747,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028341564020261504,0.05686547007380237,0.6184905301060182,-0.08346602620267257,0.14014915424319557,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09357649803292523,0.0986673155077808,0.9572656024379023,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061832280354478485,0.09863036656745601,0.5310922902405342,-0.13209249674487178,0.25575705745382876,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12511566767619228,0.19709821022418186,0.9462574637850627,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01096326042180277,0.05874104465090301,0.8520439658041483,-0.10453204175492083,0.12645856259852636,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10986856223756157,0.091967759268591,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06041203473985563,0.0909157736094203,0.5067807406719214,-0.11834448564642544,0.2391685551261367,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13293772610606072,0.16814769091493076,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020916581889806725,0.06546913094824311,0.7495309105772117,-0.10780733010481228,0.1496404938844257,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08383370520887756,0.0750876343914223,0.9643073530246201,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06810222819156228,0.058629347261606235,0.2461326023966966,-0.04717345712601538,0.18337791350913996,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10363116421877444,0.14500201948203847,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04770266388183472,0.06110121311580752,0.43545210392700273,-0.07243314769784737,0.1678384754615168,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08002907725131009,0.096910386640936,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02515406846025694,0.05917976873913278,0.6710425226198033,-0.09120384301195059,0.14151197993246445,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06206970266032445,0.07948879548731883,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08342399180674052,0.07016316779810491,0.23517639627380646,-0.05452922837647793,0.22137721198995897,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10274278836846816,0.1750359738441138,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06584196200955503,0.06365060779731421,0.30158888646256776,-0.059306411244135715,0.19099033526324577,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.0520889736984472,0.05494477575808764,0.8896367821404172,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05106491671756166,0.06903264924615005,0.45992231483410817,-0.08466550367463516,0.18679533710975849,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08169461544264264,0.10880555111902103,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03884012468310985,0.05152682800128646,0.451441774663599,-0.06247074926514837,0.14015099863136807,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.054764566758715404,0.05271058241736314,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04310586876693336,0.059510163335428065,0.46929640120207106,-0.07390165702458801,0.16011339455845472,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08304365552082063,0.11982517419239916,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0116533855135342,0.06870123933181803,0.8653953285571909,-0.1467321952912516,0.12342542426418318,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09004113157620648,0.07678503564732067,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09898631420212212,0.1248899963845633,0.4285085618702028,-0.14656954809157505,0.3445421764958193,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05380010332108056,0.12580353283600296,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01787623895402945,0.07598045757893117,0.8141216867782778,-0.1672672816185981,0.1315148037105392,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12060797895471716,0.13170484304551672,0.9769437249386967,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04165134363074981,0.07345325205758169,0.5710153767020206,-0.102770765180402,0.1860734524419016,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12453518919233994,0.1528510801859041,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004409366628575938,0.05989369869157171,0.9413512888466864,-0.11335225763219331,0.12217099088934519,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06248756599267268,0.04880146563533077,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08125106784995745,0.08759502817040363,0.3542115857596071,-0.09097627859652527,0.25347841429644014,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09539451521210572,0.16172957351827766,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08775632337729879,0.06539839599086675,0.18043225014750072,-0.040828511157510086,0.21634115791210767,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09706213768110564,0.15007242910465182,0.8012048953586696,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02615695284701337,0.07160896469498984,0.7151078939946012,-0.11463896021789062,0.16695286591191735,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09960992436838088,0.13516396543527362,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0725375477936082,0.06825885925914126,0.28859519153401125,-0.06167146437539438,0.20674655996261077,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11526522033472625,0.17184597423127704,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032763771101798796,0.07555112773435027,0.664776928763884,-0.11578313301487642,0.181310675218474,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12770551525721288,0.16724310130381978,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021552653864842355,0.05059227649050757,0.6703421950778603,-0.0779207262189709,0.12102603394865562,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12082368334609521,0.16130589138396983,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02748410340707389,0.07385378822695902,0.7099928768754589,-0.1726937372986846,0.11772553048453682,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09764840229439742,0.0904444775399082,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04640158099736971,0.08936493514166761,0.6038953901374584,-0.12930571616646344,0.22210887816120287,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1267307259646905,0.15937216294517317,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028760818200130246,0.07608247458669694,0.7056239727577891,-0.12083080797821649,0.17835244437847697,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10218737438492291,0.1335427722961792,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02224770692044884,0.05261124850035984,0.6726275978728637,-0.08119532987869915,0.12569074371959685,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10401107850681673,0.11865677521823187,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08135522425532055,0.05453196593212731,0.13655344227304786,-0.025864283348806125,0.18857473185944723,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.0989757468237469,0.14194661322116156,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02735852921173547,0.06607466710994751,0.6790657927315036,-0.15727303259591208,0.10255597417244113,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04469042472973015,0.007926699474035348,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04189506266694584,0.063282688867717,0.5083498809076022,-0.08252991677917983,0.1663200421130715,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09354778387911782,0.1066951677278183,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04749532110857671,0.08133072534467815,0.5595791611933658,-0.20740593822068343,0.11241529600353001,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04457643122259426,0.0046090615540821285,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03753997921665159,0.06282599602282259,0.5505113442959296,-0.08598706117448288,0.16106701960778605,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10124605509187964,0.1186074784238239,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03412170686678955,0.08315354188537223,0.6817817483282509,-0.19761630428485352,0.1293728905512744,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06780744278937019,0.06081610625110646,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07519926668479916,0.06418275760694654,0.2420688329762759,-0.05099540738686363,0.20139394075646194,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09263562096003047,0.13214939761186575,0.8491564414671808,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05059719852955405,0.08427053104828855,0.5485855272236884,-0.21628799456250192,0.11509359750339382,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06037983139596437,0.0352012776099129,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010798675421584797,0.03986158519866968,0.7866105642525846,-0.06757626419898244,0.08917361504215204,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05032126012461909,0.017231110299247215,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02550503010276456,0.05334730955233604,0.6328560478916673,-0.07938523314807035,0.13039529335359945,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06782784227335552,0.04701431722393923,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02551832669755873,0.055002219901194575,0.6429465366154556,-0.08262578353459413,0.13366243692971158,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08803456349764531,0.09476537386609837,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053153582836774675,0.06279116450807568,0.3977948168963761,-0.07030497262453134,0.17661213829808067,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1077635783864807,0.12800725603700785,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06510431190739988,0.0807272483868325,0.4204708951898598,-0.09361976257480822,0.22382838638960798,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13262680177303926,0.19964804035015463,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051169769637317404,0.09143686847305563,0.5760667533964322,-0.12861131558426703,0.23095085485890182,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1308463048872085,0.17256844406086705,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029209421184419746,0.05688557014640254,0.6079139018231483,-0.14105653171164068,0.08263768934280118,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09004553037330186,0.04458896864201786,0.9536302663534211,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008559384015839775,0.07030749971355627,0.9031671032988315,-0.14679638631917316,0.1296776182874936,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10302350493555992,0.08856799735835043,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062323359185768194,0.07725440927305503,0.4203233917335579,-0.08957249824240923,0.21421921661394563,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14737525445270067,0.17456574330347438,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023731848278510043,0.07500604691856183,0.9747756943322912,-0.14510199382148944,0.14984836347719147,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12185131293668144,0.11542440426145704,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06452378589259458,0.07712257424422424,0.4033169745643186,-0.0871128605089016,0.21616043229409077,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10114367975009214,0.13753970731123458,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03613281610745105,0.07255444182001067,0.6187630321415154,-0.10652207251541965,0.17878770473032177,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11528436851815653,0.1219123851652998,0.9572677741452639,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011173265321285123,0.08338964554611798,0.8934819338357881,-0.15278555372928335,0.1751320843718536,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08550820729919595,0.09845944810182493,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10147335921428119,0.11008208885748731,0.3572146621091298,-0.1149675330510726,0.317914251479635,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14953128547619235,0.22813712838503772,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027762483993358778,0.0855409530176937,0.7456973774760716,-0.1404261867389649,0.19595115472568247,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13299270266873128,0.18175017109798788,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10280408977746382,0.10871864200322284,0.3449500215743644,-0.11095602438169473,0.3165642039366224,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11542567713941576,0.189631088192035,0.906393006043464,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0335063013144443,0.09172736162438203,0.7151029805712599,-0.14684594491546238,0.21385854754435096,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11427005682914763,0.16080462945824345,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06636547769382488,0.08552739939982344,0.43825399564333356,-0.10179654422418478,0.23452749961183456,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12667878852970987,0.1950842122454125,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024787055024176826,0.06389681679214661,0.6982884103102773,-0.15041951878776214,0.10084540873940848,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12893389911149133,0.07788526170365623,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06815989010819351,0.06127065307370468,0.2666470114015415,-0.18862885066836182,0.052309070451974804,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.02883518941250011,-0.03158688526551105,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0977215400501938,0.09084709223243388,0.28275176417004666,-0.08089994057920004,0.27634302067958766,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1429659341176256,0.12554732288199097,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035572770021972136,0.05456926897991429,0.5148677491868404,-0.07172008198387356,0.14286562202781783,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09472332425499276,0.11159904076552819,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07238852636026101,0.0876148932094974,0.4091978985590209,-0.09987787827298912,0.24465493099351115,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.17858363328023152,0.24812502616924156,0.9256805126137099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029038487134395132,0.05156940416490855,0.5736995024636846,-0.13043307336445362,0.07235609909566336,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,-0.03730944935988621,-0.07438495272561284,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012480207193885167,0.04469598920048133,0.780223396643279,-0.0754000273078315,0.10036044169560183,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07267015914260218,0.06445400425301902,0.971058846433733,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0672281682667833,0.0590527180536424,0.2556470454291549,-0.04887993904549351,0.1833362755790601,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08630017300978786,0.15862930752775634,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03146951089463829,0.06489226719687818,0.6279889952832709,-0.09612018474964779,0.15905920653892436,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06483427059155031,0.0708169063687037,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017187029537406195,0.054817693558816535,0.7540481848500951,-0.09059426920919726,0.12496832828400965,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09969912251175848,0.1304732500765187,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05619271565594462,0.05676604436498987,0.3228478868061907,-0.05541938600610875,0.167804817317998,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1049467591523521,0.11679482757567511,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048442983977378506,0.06085737291398062,0.42652020267249735,-0.07121339455918697,0.16809936251394397,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10636951026720999,0.12514239287362375,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06321772056918303,0.11112017035436925,0.5697485676149175,-0.15526422385789124,0.28169966499625726,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13150316424636257,0.19402607191306337,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033566008893326775,0.08571773353934603,0.6955806638688037,-0.13497024366850868,0.20210226145516225,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09842963399132042,0.12179932657814047,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002982338056897976,0.048703770063926635,0.9951174337063123,-0.09605847562822604,0.09546200801684644,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06691078700080119,0.05751599423121501,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06449087993524202,0.09987953428988465,0.5188689648740783,-0.13188998224786386,0.2608717421183479,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11573137623265893,0.18125941630317502,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.069899851144133,0.06901398080950435,0.3117778671713184,-0.0657938637937367,0.2055935660820027,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11365429438803994,0.1664188641379283,0.8990379896110621,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025371697364266206,0.09249056406038005,0.78398922066064,-0.15648114008752723,0.20722453481605962,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10959983460901562,0.12505710390728936,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08696370640027455,0.08528148493268925,0.30850234324679804,-0.08071480410148292,0.25464221690203204,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14937518645594328,0.22797498034673094,0.8969323713769235,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004852825427258832,0.06931601994057861,0.9442221146688645,-0.14114040281548046,0.13143475196096277,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04317268252310954,0.03923170319016523,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023691533881534284,0.08030941773876567,0.7681512928050442,-0.13421101151068288,0.18159407927375143,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09762021714843887,0.10466862574833194,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061761611517775115,0.08998147660529292,0.4928879505532654,-0.11515791540923417,0.23868113844478442,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08150346563099824,0.15967366777925776,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04573192064766604,0.07743223610964362,0.5551329727465639,-0.1065135758505856,0.19797741714591768,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10534943641444716,0.14394073196576973,0.9497080900134104,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008577723012449844,0.07575614011715423,0.9099090520594071,-0.1403722717751971,0.1575277178000968,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.017561000464446398,0.039537754780478336,0.9890962952045544,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10145697845854892,0.16300614273115552,0.5340413683665897,-0.21904198139621986,0.4219559383133177,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.2974558699890219,0.3944898403655964,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07545005955563501,0.07125924083018143,0.29035322107420874,-0.06465823442308306,0.2155583535343531,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11818494669984382,0.18552317332331017,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06555586389181389,0.06677961938404035,0.32687982194254916,-0.06574470057453091,0.1968564283581587,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11860009640888089,0.1675312358748955,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008848165171549169,0.07473248821987338,0.9058145075005876,-0.15578547894708866,0.13808914860399035,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07568607822957014,0.049893706027553365,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07998534230440454,0.05794975532052622,0.16831373237771027,-0.03395414483933462,0.1939248294481437,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11015478528923041,0.16491588488236716,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024108450444009995,0.07532176106923004,0.7490876464351954,-0.1239874781672965,0.1722043790553165,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06872578792875324,0.06270603503578366,0.964192424193284,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006007141115466747,0.0756407876102347,0.936742669824677,-0.15473033243506695,0.14271605020413347,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.080209805375884,0.05291158428531362,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06991780257832092,0.07137916377287024,0.3279380779769978,-0.07042628115500707,0.2102618863116489,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07132067910186388,0.13472441394042892,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00011348220324694329,0.04957806443450309,0.9981748675321652,-0.0975927416755584,0.09736577726906451,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08140561167724349,0.024131224426114685,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04937001080176682,0.06566672460522613,0.45261691160169304,-0.07974240533432744,0.17848242693786107,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13624697999394322,0.15885152076026354,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014870224488251964,0.06672757382539843,0.8237712295579112,-0.14606845816429453,0.11632800918779061,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06461741468326093,0.0457236983786784,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09730276574035168,0.11171582335954418,0.3843081436354887,-0.1223503380393354,0.31695586952003874,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15134710243480742,0.2490468957569414,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028197843600519,0.07772770281698033,0.7169713905740964,-0.12462859279844124,0.18102427999947923,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10692861295041287,0.11994565984261336,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0849034472335634,0.08749923774525128,0.3324926279931403,-0.08713555826385454,0.2569424527309813,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11173418255731739,0.1718481437334262,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04135451790286798,0.0855062179243,0.6289153598736961,-0.12676585748109265,0.2094748932868286,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14615374447177223,0.1910600067307895,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04107727577866772,0.05081015842993133,0.4193356803762832,-0.0588244988048033,0.14097905036213873,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13229204304671316,0.15383698231479367,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0891047267595858,0.08343910364245612,0.2862376705675682,-0.25316078919109186,0.07495133567192022,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07672845152299039,-0.002873260818659967,0.8779577391674485,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05288379396068406,0.11029693158449698,0.6318797457828655,-0.16397951717419984,0.269747105095568,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12226212053998156,0.13566751330256208,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020216690307795004,0.05601308479934586,0.7183522695878948,-0.08991495943043352,0.13034834004602353,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08472561016799819,0.05941484634587466,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016824572983154734,0.06186207533561934,0.7857923262981887,-0.10480722853872645,0.13845637450503592,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09111609679181436,0.07980040252236519,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05674212472889325,0.05373691699777645,0.29166832947437427,-0.04891417579466744,0.16239842525245393,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08906875697439123,0.06817054984263857,0.8799526010712531,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03840174962648746,0.06283524008406897,0.5414628999284529,-0.08514346622702322,0.16194696547999815,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08440650704091486,0.09613430447078347,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011248457703018785,0.05763023676487043,0.8453529812817056,-0.10206279934444189,0.12455971475047946,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07748555641632845,-0.003924276652954659,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04217641148598899,0.05515201227974691,0.44490311577228336,-0.06626221710428104,0.15061504007625903,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08395512240679616,0.09551052992681201,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0433678344563702,0.06015740008465134,0.47140710366450345,-0.07491227346874577,0.16164794238148616,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.0969718072754186,0.07734650829107458,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04697411085773387,0.06149273155798905,0.44539897553934793,-0.07393149535287875,0.16787971706834648,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07319710735736215,0.08016258606289466,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018818722094466025,0.04953936448235956,0.7042494209293841,-0.07858444641464235,0.11622189060357441,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07394188476727781,0.059216778043184544,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01455931245781618,0.058154645441896094,0.8024469834592278,-0.12890164988488403,0.09978302496925166,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08661436530933699,0.03294188396640665,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03623479047249377,0.0482295265995032,0.4529341697574527,-0.05859300466724282,0.13106258561223036,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06826104819515644,0.07719565663872735,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009414080079995614,0.06309482206758568,0.8814701926639938,-0.11464151994873818,0.13346968010872942,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07741251366295632,0.07502330957058984,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07048742779060865,0.06713433550122884,0.2944049816586937,-0.06151057141468419,0.2024854269959015,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10307823322628354,0.057499948933375726,0.880884562535511,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06888546478952919,0.05737010813378558,0.2306017153309378,-0.04391433327672831,0.18168526285578668,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.054686864224564896,0.09448808900682763,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019685636509134127,0.04658372981685164,0.6728344171253717,-0.11127750355355892,0.07190623053529066,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06431520075793647,0.02239490325198907,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03244196791554455,0.06233350583813109,0.6030451632257774,-0.09011674950758597,0.15500068533867506,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07916369464925033,0.0738991160814765,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009134506823529221,0.04664873281967412,0.8448590645843129,-0.10085418128945961,0.08258516764240117,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07418997623925644,0.03416960026199916,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045259680714702384,0.04425833513757695,0.307130653494901,-0.0417600483509191,0.13227940978032388,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05937765325639043,0.07487366323570256,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02777538961595172,0.054411232573334065,0.6100151751146908,-0.07920673481190518,0.13475751404380862,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05208156603526468,0.04754964583238421,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000440358808361817,0.07165990478729886,0.9951001329046332,-0.14045571150415506,0.1413364291208787,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1685308178009357,0.18816857813770174,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0033752708560701927,0.06614205452198418,0.9593277145824597,-0.1334222698327637,0.1266717281206233,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.046484022669068766,0.0028673853918848784,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1127921796474633,0.1467957100347482,0.44296178876637404,-0.17625223947273388,0.4018365987676605,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06447098139674048,0.2580407403766135,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14347135946689468,0.13017148673448806,0.27139451606977905,-0.11283954880335526,0.39978226773714465,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05674780881536847,0.2614159114198242,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07221178720082841,0.0835803541985524,0.3883859341005318,-0.092360017543754,0.23678359194541082,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03113035366518046,0.1264209209366998,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11144014088322225,0.12043871372149072,0.35566588067746785,-0.1257066942591098,0.3485869760255543,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07125342131267699,0.2751702869894134,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07324990179999777,0.08878959770366891,0.41012891552804787,-0.10157903350129943,0.24807883710129497,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10434444956147135,0.19470275538501536,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010132267128034222,0.12812584537428368,0.9370286601913234,-0.24215072221632505,0.2624152564723935,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08660221014526098,0.10867365797001892,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04992811709115956,0.10145268165093932,0.6230365242346334,-0.14983474674893932,0.24969098093125847,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08979380496563105,0.19711976222460328,0.9584620018167673,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08725038357358583,0.09461602303607046,0.3572943005573195,-0.0990509287157893,0.27355169586296096,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11127323071080354,0.19377138123635262,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11125125940502092,0.0766968042975392,0.14810147622441017,-0.03976666367536105,0.2622691824854029,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.052012375113030404,0.17935415166941204,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11972726928890139,0.11224822558106964,0.2871173245785008,-0.10129229015648773,0.3407468287342905,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06948952079133283,0.2671156004679543,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11102532312055444,0.09097077007411956,0.22338726713872986,-0.06809839505054663,0.29014904129165553,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08119117388757119,0.24493350335041206,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10740617449062617,0.11657803176968883,0.35772548521777514,-0.12213888147231255,0.3369512304535649,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07007060898597364,0.24296981503655324,0.9120511198404183,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13689348538275442,0.09369536403723472,0.14519575629893594,-0.04759502634546489,0.3213819971109737,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07271914158505957,0.2547899482297646,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11490635955640754,0.07949583269515323,0.1495251710051348,-0.041622920341539305,0.2714356394543544,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08734563424511567,0.22046115152360068,0.7663649588223891,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08533277203124942,0.21204919846509454,0.6877020621808458,-0.3321973954425701,0.502862939505069,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11364475149934615,0.18076566168176833,0.9632925656593531,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07605654078948829,0.15625878405607724,0.6268518695601961,-0.38373398898757216,0.23162090740859556,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08076434848402766,-0.05145875202673256,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1110990044635716,0.06935633445049914,0.11038736898340033,-0.025465350167808848,0.24766335909495205,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0370506961899871,0.15434820961831527,0.7002905874282662,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0793601950775244,0.10210776295247437,0.4377275079242594,-0.1216925402052337,0.2804129303602825,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06802313527775163,0.20795033091424334,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14900269448181983,0.08147561985650646,0.06856182454632226,-0.011424835779843462,0.30943022474348314,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03536373304415142,0.21746675573206412,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09051247298979193,0.0806100742255496,0.2625280692109339,-0.06821077630846492,0.24923572228804877,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.041960244727874595,0.18458535330952927,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13994504882508543,0.09749400794087609,0.15235507037628243,-0.05202308761636695,0.3319131852665378,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04554984629054269,0.22682951751283653,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03187894341451848,0.11840893784715648,0.7879657061423812,-0.20127121233982426,0.26502909916886125,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.055687278843723154,0.17061637831108514,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1709535340314092,0.0624573163315141,0.006620533730658547,0.04797351837171747,0.2939335496911009,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.020342785103635054,0.1491239980313318,0.1564101093868082,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020857932057087088,0.10974865852368111,0.8494151311278696,-0.19523991742835956,0.23695578154253372,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10145239669477957,0.18360623442361013,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06012512289254955,0.08236543578468522,0.4660520835410128,-0.10205447715387413,0.22230472293897324,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.054594569796341086,0.15051495609175025,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10520155836172643,0.08318564260413377,0.20711272688051524,-0.05859304939595675,0.2689961661194096,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.13213579828893057,0.2494216331874186,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047206751092065916,0.07712370555847078,0.541006138991724,-0.10465175123248092,0.19906525341661274,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.02733511181574482,0.09732140172011511,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08232128814751968,0.07872546368691537,0.2966709872897282,-0.07269111593408617,0.23733369222912554,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1429525402502438,0.22755332904477152,0.8839993607754738,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11284449961646627,0.08681853927772687,0.19481641884961515,-0.058103372419129704,0.2837923716520622,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05531505629749497,0.19955086924545704,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08019309153557228,0.058295162849292266,0.17010390823098673,-0.0345915399724086,0.19497772304355315,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08965062888731358,0.18185256097339222,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14442751962784545,0.0795411790075667,0.07054620606373146,-0.012191048291717937,0.3010460875474088,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10792033011575325,0.2731888315449906,0.6147044826936338,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09733920105045377,0.1061525924881058,0.35999618353220664,-0.11167790460314184,0.30635630670404934,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.043198608352072315,0.19909941567898826,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05172064065667746,0.10644106738127372,0.6274364869764991,-0.15786447926590969,0.26130576057926463,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05956873532917901,0.17545635932945788,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12578430085949432,0.0800411899236997,0.11727004516426572,-0.03181880104115889,0.2833874027601475,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.02134901056632403,0.17347633957545558,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03616533012955293,0.12122239320406762,0.7656802439308042,-0.20252458948550817,0.27485524974461406,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04258161215453818,0.1520796532689727,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04089740462444368,0.07593327265085675,0.5906207787585454,-0.10861710557525553,0.1904119148241429,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07857476035348636,0.13415539961592618,0.9533037295212146,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06408964291737484,0.10764435901526842,0.5520993153263143,-0.14786478828343605,0.27604407411818577,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0711987804065023,0.15386339301506596,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09970724090886394,0.05515576957289601,0.07178952696007973,-0.008895846834990506,0.2083103286527184,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08034880041993485,0.17405820479104409,0.6200927802057812,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06785399650073062,0.06013501576424952,0.26019581054871493,-0.05055335134510876,0.18626134434657,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06164637823413617,0.14186960483271366,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06518987968549939,0.07168609813447241,0.36398236262693107,-0.07596183782291596,0.20634159719391473,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11028185433583557,0.17858044489904637,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05630381030058769,0.07076741075892103,0.42697171654605337,-0.08303898882215786,0.19564660942333323,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05673188808530916,0.12400473173622918,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08733887802312387,0.07915301175030143,0.27085416243905014,-0.06851537887283288,0.24319313491908062,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07799493650319012,0.18223467942760999,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0927634485408563,0.06975453128136366,0.18471806021004322,-0.04458496559502528,0.2301118626767379,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0671648472450694,0.17214515535238648,0.8047111541643488,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11348439709968229,0.0920134383414004,0.2185479006631731,-0.06769236092919058,0.2946611551285552,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1251918007528755,0.2510244496489427,0.8332532350933084,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1298328130007047,0.055165353326541114,0.019332960362090413,0.021210854606579316,0.2384547713948301,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04601395935175007,0.18265608453520019,0.3170765275914746,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09920965155820284,0.06556098824448539,0.13141890670928708,-0.029881571608929694,0.2283008747253354,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08143973879899001,0.18584846099639307,0.7364614878814166,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13049543542648612,0.07912774569979118,0.10030584652879149,-0.02530907198502405,0.2862999428379963,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07444161093412593,0.22101956972632072,0.6805365895261084,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06605500285016613,0.055731979308339445,0.23699784364697227,-0.043682656252982316,0.17579266195331458,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.055956873269359,0.12340059366939332,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09708826253429631,0.05606177766883457,0.08448021013445055,-0.013298777777019197,0.20747530284561183,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0683471008726331,0.1457895671293807,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07918694287508414,0.08813092330631822,0.3697329902159452,-0.09434504608815923,0.2527189318383275,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09241472862274197,0.19568421686724902,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05038992631088724,0.06250195061605425,0.4208480501844759,-0.07267797536975631,0.1734578279915308,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.04229620567832923,0.02093635915324428,0.9279699506567693,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006721533850450087,0.06744529812242352,0.9206909397290257,-0.12607994252491417,0.13952301022581431,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.18722169069899658,0.1736106063483589,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042214350227654504,0.13839274326008197,0.7605822958822851,-0.23028441745835032,0.31471311791365936,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06369875000655408,0.16675024964181814,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05232980060390419,0.08923994512301767,0.5581134785538489,-0.12338588001302334,0.2280454812208317,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04331669791899433,0.13339262313479014,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06654643799559654,0.08992185015626061,0.459931289537013,-0.1105119306616163,0.24360480665280937,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11662482672221886,0.19884891257553639,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11984943454267105,0.11863188941583097,0.3132977420016672,-0.11373971841836256,0.35343858750370466,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.15599123756108796,0.3225363950210596,0.9010715492787081,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11808654174044714,0.09910170979855662,0.23450438693433076,-0.07704719980936797,0.31322028329026225,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.12039087711081285,0.24313488677274622,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13619946305155306,0.09228911369668016,0.14119616742700358,-0.045520106636555174,0.31791903273966127,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05349393380157535,0.28742223290914537,0.7596261630193029,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044782024814790364,0.0998197778475424,0.6540688751718734,-0.1517656106564393,0.24132966028602004,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0960620990169147,0.1656500761947433,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.193743176006145,0.07935331427246474,0.015284950442646397,0.037494518441713004,0.34999183357057695,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06385144257713006,0.2880965847505074,0.27083021565564086,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0669059698184505,0.05107825025462024,0.1913821236244992,-0.03366838055614829,0.1674803201930493,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11766176078058532,0.1645052371574167,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08149860031230857,0.06932031032425434,0.24078538789878534,-0.05499482191483285,0.21799202253945,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.02296567875487062,0.08585823003422322,0.8476072767807353,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12046775634090116,0.08188252433195271,0.14242529138813534,-0.04076097899490856,0.2816964916767109,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08372257181436464,0.21884749167479642,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09310574218096608,0.10532433034319585,0.3775085442285103,-0.11428049462436364,0.3004919789862958,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.024965125874500414,0.1842301598581433,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0063276261787796675,0.09029815844865592,0.9441873695520404,-0.18412695526160552,0.1714717029040462,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06491465806817653,0.07330295816769265,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12054928479804215,0.08130657728478355,0.13936439410876247,-0.03954539641824599,0.2806439660143303,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06271285512975215,0.20785495817706157,0.7554902334520308,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03988487106750145,0.07737907368628794,0.606673151895831,-0.11247645747825612,0.192246199613259,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.047868925603473625,0.10893961803553232,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056021909302798795,0.09899029493721417,0.5719216307196857,-0.13889245360256913,0.2509362722081667,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1544467585488251,0.21258773544674134,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034013501698483495,0.07372735683099967,0.6449348110115205,-0.11115750516159006,0.17918450855855705,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08711607420497712,0.12283652617325612,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06062632622555818,0.08382473963786465,0.4701684270988895,-0.1044266795522882,0.22567933200340456,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11814563659817576,0.18698866032927133,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11663478476981826,0.06504185275223023,0.07408559103007734,-0.011434247648224621,0.24470381718786113,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08734441884172045,0.22066578700466785,0.6242218401318658,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1477865180753901,0.06800290803250901,0.030654991967715435,0.01388709386137188,0.2816859422894083,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10182583952351376,0.2649455804789779,0.4195505624822847,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1261909382536517,0.06150870464710575,0.041199382978959614,0.005078762691095931,0.2473031138162075,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06325249258644014,0.20628364169084035,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11398718955622789,0.13137463265737717,0.386376982284908,-0.14469274308343993,0.3726671221958957,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07750545022907043,0.27986025370259554,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08245166417820132,0.06909733627701538,0.23383961322015334,-0.0536027165813944,0.21850604493779704,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0961873215372992,0.16941784921403136,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.098324787854685,0.10311617751750006,0.3411950978824311,-0.10471354089065592,0.3013631166000259,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0941115235914938,0.24281588748769214,0.9043732915535342,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10887217118653134,0.07478482739925056,0.14663901960599673,-0.03838102163159532,0.256125364004658,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08345247376223722,0.19576135646428303,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1267064202426961,0.06511832357535066,0.05274548027731344,-0.0015131851358457793,0.254926025621238,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08299905162103571,0.23041190164555317,0.5404408711479688,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14652700275205088,0.07601720869443475,0.05498794485344029,-0.003152779613663975,0.29620678511776577,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04677985814272686,0.21409184980290932,0.5490494418196339,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09745836383732129,0.05128607503974197,0.05848873878320033,-0.0035251987293781345,0.1984419264040207,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.018079581940175657,0.13811189392035692,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10373717312252641,0.08431333798272285,0.21965538152286712,-0.06227789499855328,0.2697522412436061,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07016830995603378,0.2242572355053235,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12665417721275438,0.06513554562592304,0.052904748952731964,-0.0015993388134663278,0.2549076932389751,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06997862795725308,0.18331643138434364,0.5409607190737244,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10720228551548179,0.08132310260800428,0.18857468670067923,-0.05292493447492978,0.26732950550589335,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08693292805850304,0.19724686477376818,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14399843283944985,0.06457670240627034,0.026599627247003006,0.0168452930692215,0.2711515726096782,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.036955554225722165,0.1781449988126562,0.38460444642387953,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12368029277365206,0.08311653707475983,0.13793974440387533,-0.03997824447085904,0.2873388300181632,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0647112764605942,0.2136473241301812,0.7515207213987387,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08769613633406334,0.055724863371763446,0.11675102749073268,-0.02202751131225425,0.19741978398038093,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05664536349676291,0.15897811798766107,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10701051049848775,0.11103966582158831,0.33607445660081814,-0.1116293645980288,0.3256503855950043,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.0070759971120545745,0.1362019789036281,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06806505636039098,0.07840543424779167,0.38612196617473904,-0.08631720176319624,0.2224473144839782,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.043967482611057776,0.1772181159060078,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09144898655387233,0.08938061949173909,0.30718129960673546,-0.08454368540825567,0.2674416585160003,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08058846125204595,0.20466652289710463,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09184778628260101,0.07643549796451911,0.23058480309324153,-0.0586556181022255,0.24235119066742752,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06680491527858003,0.15319398125131026,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11048548646977353,0.09764239005016584,0.25886194174522875,-0.08177481805055072,0.3027457909900978,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07220030292588683,0.2346467437670122,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15661159308151146,0.07938877354567735,0.04957506777142357,0.0002931153225673999,0.31293007084045554,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09557447089780798,0.25501434186507393,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08428186132547338,0.10445835197114904,0.4204839302249258,-0.12139924243843656,0.28996296508938335,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06225537736232146,0.19280009820782426,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08122088050455728,0.06763606590621038,0.23088916200846793,-0.05195622240129935,0.2143979834104139,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09446705535811636,0.182350893296907,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1067135482864707,0.10859483377953057,0.32666999218420434,-0.10711239146223664,0.32053948803517807,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07268995514733531,0.2417794985842744,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06096164321195219,0.07541316381642832,0.41960894914395197,-0.08752875970361002,0.2094520461275144,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06233108278916277,0.13394454431030767,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01670879016653845,0.07226076632618478,0.8173166317386179,-0.12557446336306605,0.15899204369614295,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08727558997381171,0.11073493776440763,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13856031560423024,0.08560828587507441,0.10674515203711306,-0.030004537256792335,0.30712516846525284,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07483682660495508,0.2527635464053682,0.6917085852004926,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10220812868627854,0.0853193374991525,0.2320157339143189,-0.06578777760638518,0.2702040349789423,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06592811181632731,0.20851524910011032,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0949919592971632,0.061202764869525854,0.1218441237168148,-0.025517813202827533,0.21550173179715393,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05245146645072815,0.15780719428882486,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11695600546335315,0.06778312060761361,0.08562204212947895,-0.01651065182209628,0.2504226627488026,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10754512651524407,0.20875319547260493,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060173381675875076,0.06142010552131819,0.32813372348804104,-0.06076433999533906,0.18111110334708921,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.045631585767501044,0.1074861230381625,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07451386607766611,0.07680337920520068,0.3328432135152761,-0.07671390565749273,0.22574163781282494,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06772499927641001,0.13276122827839662,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00417605453171838,0.0775789585296707,0.9571116876677542,-0.15693096132600123,0.14857885226256448,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05749559008868811,0.059398972263207984,0.995747388821315,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08485925255482167,0.0707431491613867,0.23139748790010692,-0.05443577487647201,0.22415427998611537,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07000367904313606,0.15912479821392186,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017925158457544638,0.09425899402133343,0.8493232365128696,-0.16767315478540543,0.2035234717004947,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06524776634152782,0.10358375594645537,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0575156450172617,0.0645463796338833,0.37370355822647805,-0.06957778845685861,0.184609078491382,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07392036282576199,0.10601388740701205,0.915824547329523,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006763009904063484,0.09979315069206193,0.9460199943736649,-0.20325821584116813,0.18973219603304117,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.055281320464902285,0.0668337456657873,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09499674988951048,0.07327840916489586,0.19598055601184763,-0.04929026780402937,0.23928376758305034,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.046453207255743735,0.13182542059124447,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13734357790795015,0.04907232789001524,0.005509059462132881,0.04071893876496856,0.23396821705093174,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05942679102938584,0.1755565491564619,0.14061387141611192,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09621007824996929,0.07177101114654888,0.1812349317925264,-0.04510883509983395,0.23752899159977253,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07389475897602188,0.1752437240656717,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14439903869171103,0.08083644781903267,0.0752007898728499,-0.014769945865546086,0.30356802324896814,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10055802985015869,0.25512690488849765,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04211944291061581,0.1252766361566005,0.736979484721257,-0.20455338232825154,0.28879226814948317,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11615466644445654,0.19101054512543678,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09982299608158746,0.11589226667928229,0.3898337519087989,-0.12837177129211017,0.3280177634552851,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06941648702350531,0.22005071291990752,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028161812774816455,0.08044722676000425,0.726569591241071,-0.13024078579684484,0.18656441134647778,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07120399538481513,0.09796636859577294,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057021273947998156,0.07566605793349267,0.45176884827659425,-0.0919670837998168,0.20600963169581313,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07129248076464911,0.16223049061891703,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04325273975492641,0.08176411644252397,0.5972556741106138,-0.11774284748949101,0.20424832699934384,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.120938946581761,0.18210773887262888,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1265481373735863,0.08067762873147477,0.11795157039355973,-0.03230812843393688,0.2854044031811095,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10053398880856848,0.27006035383880994,0.718572191699215,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060781110683277365,0.09094452374469582,0.5045079884140387,-0.11829092780971508,0.23985314917626982,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.062391368092715706,0.15359489356927244,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1359343864223096,0.08226085945016272,0.09963011359586921,-0.026039300209760058,0.2979080730543793,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09706452153250239,0.24882726666706587,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023927071131380304,0.0968749712364255,0.8051092747885933,-0.16682216657924642,0.21467630884200706,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08070440557887909,0.1088607041322897,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08999565860480416,0.11172358605607094,0.42124695364572473,-0.12999087251356609,0.3099821897231744,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10834501175713784,0.23964686170438473,0.9282753503874777,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06913159517934604,0.09848246796372126,0.4833195264126766,-0.1247828437327929,0.26304603409148497,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06836663645640889,0.17379036643619003,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05340374564646248,0.12048670331963843,0.6579612115937222,-0.18383758221310997,0.2906450735060349,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06887751622924737,0.17208219382773016,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06840591367816456,0.09777392609483093,0.48477455871288977,-0.12411338859907364,0.26092521595540275,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06161133152648331,0.1622262034610966,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06995830794591633,0.09000191928250353,0.43768160176747006,-0.10725771882050737,0.24717433471234002,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06904354428533409,0.197817809811659,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12462681142600862,0.06045372161890098,0.040235800828331524,0.005591923793031514,0.24366169905898571,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10551663300302432,0.23860038361094935,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02725625844301772,0.06581133671983214,0.6790963318345298,-0.10232790712425101,0.15684042401028644,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.01716284435339601,0.05327405742817501,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22950409310221984,0.17526362517398372,0.19151483233208974,-0.11559436188207464,0.5746025480865143,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1611205428446621,0.3416287724702098,0.8125064948355263,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12289919553714451,0.07565933939175161,0.10549346446227664,-0.026075933234194104,0.27187432430848313,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05236929498855974,0.2023550365962159,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08994431353881993,0.09348588155381135,0.3368748037810486,-0.09413172194794361,0.2740203490255835,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11442743672875291,0.28017965952344354,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061644529846743894,0.058672642417363835,0.2943828800161665,-0.053883368357907906,0.1771724280513957,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.03239166026497646,0.014199588948922037,0.880884562535511,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11443840458633314,0.04518737436787219,0.011906471963919644,0.02546333595090243,0.20341347322176384,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05486148469590521,0.15956009082702557,0.22774355289058826,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0817202751364226,0.06675876642595227,0.2220050334990744,-0.04972940318321398,0.21316995345605919,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05412818888642131,0.16634008643417322,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10737512463031318,0.07603865566946623,0.1590989922820534,-0.04234688736485334,0.2570971366254797,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03904363268947769,0.1473629710949584,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0674234809862242,0.07918652979145434,0.39529324884934425,-0.08849677376983892,0.2233437357422873,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06457025504423575,0.16027388567395537,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13118449618423053,0.0666830442135647,0.050201415160740795,-0.00011608320813577544,0.26248507557659684,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10477089983719622,0.22177908471787047,0.5271148591877783,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11180261206591532,0.06948385357599138,0.10880627778156628,-0.025012830908209577,0.24861805504004023,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09721439839042859,0.20925394245862625,0.6983913976492675,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09595976841558151,0.12432918884780661,0.4409139240312103,-0.14884750941081376,0.3407670462419768,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08695497880141553,0.24418803639230155,0.9320838159679753,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09851237694090295,0.09301752950383216,0.2905381251415821,-0.08464146166287304,0.28166621554467897,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04540715096654278,0.17236283017293863,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08773441004652902,0.06359040131847325,0.16885702813724554,-0.037476678250039475,0.2129454983430975,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.043793624999291444,0.13684197542132953,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09659571045764026,0.12674955320506845,0.4466838089248538,-0.1529773252341475,0.34616874614942805,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.056416649027180125,0.22605526160115053,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08526694110137753,0.06697574312359743,0.20410607549351373,-0.046609969754677294,0.21714385195743235,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0973125136128598,0.20739470635200777,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06300628660577352,0.086533118947328,0.4671893663650647,-0.10737958567120752,0.23339215888275455,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09701503237243624,0.18149811294594345,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15843622765510199,0.10436126495624842,0.13017730539561512,-0.04705370935182698,0.363926164662031,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10637399514389113,0.31411315508383003,0.7333906673033306,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11162694643696672,0.11484840670347068,0.3319683127452877,-0.11451243457510041,0.33776632744903384,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.013885661531849218,0.17660408224302582,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09257375133086956,0.10953943505415961,0.39881310729914676,-0.12311213191796269,0.30825963457970185,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.022841830196802054,0.1526970292419022,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08098499790108674,0.08472777577826515,0.3400379729732398,-0.08584610858954494,0.24781610439171842,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.028355920540545372,0.14140955855485104,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14093300913081702,0.07059757520482629,0.046933615537392906,0.0019246204555405932,0.27994139780609345,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04577665685093031,0.2324764585515657,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07257731579390424,0.09762565755342348,0.4578882460855255,-0.11965004202245856,0.26480467361026705,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.02269241515112901,0.09170840470107056,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16279190273342067,0.19593309323466246,0.4068094300216417,-0.5485890565264756,0.22300525105963429,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.4413617186560483,0.1813994803301031,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12973329278183746,0.06342917946799324,0.04181788427511798,0.004839654335202892,0.254626931228472,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07134982570057626,0.23452141479726252,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12145341049126197,0.06157623308791605,0.04961061039220259,0.0002082697423019947,0.24269855124022194,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07083261518442774,0.2157873729814163,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06728901496446665,0.10359279519207049,0.5165478642373689,-0.13668778588510686,0.2712658158140402,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0590801162593292,0.14270651315710567,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12323129954488997,0.05367470235447445,0.022469028644238737,0.017544470142136157,0.2289181289476438,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09061789350960289,0.2315330897863707,0.3497238223097394,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06514050372649303,0.0928854612691833,0.48373634420621614,-0.11775328922500013,0.2480342966779862,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07403200803928418,0.1519870912301706,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09172295765282817,0.10165267622079635,0.3677140205099375,-0.10843370048996415,0.2918796157956205,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06489224076033531,0.16769984388361522,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15378791628428953,0.08084559118839409,0.05823183609462931,-0.005399071795585825,0.31297490436416486,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04065941933244761,0.2305697146106842,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09235427166683928,0.08162271394351943,0.25888477735621956,-0.06836289052566595,0.2530714338593445,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0631828562569767,0.1550069947180938,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1172261372740994,0.0770197375635864,0.1292036658867419,-0.034427649472033486,0.2688799240202323,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.12353199112237723,0.2570089399089921,0.731539728822366,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09562938172561448,0.10199044901588214,0.34929443693942774,-0.10519235948620669,0.29645112293743564,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.034851525911543335,0.1406805780317757,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09044640746879141,0.11437948377108038,0.429798135646852,-0.1347696525785635,0.31566246751614635,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08833959040263496,0.24955353644267667,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10155573837969659,0.10757459170809958,0.34601079911646226,-0.11026131925093693,0.3133727960103301,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08992736794984306,0.2216968003674091,0.9073781709238445,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05438678483785447,0.10720890100717112,0.6123713513984992,-0.15671021866992693,0.26548378834563585,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05943426208829979,0.14951830813887682,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.102861000647709,0.11414654232865214,0.36834306360251234,-0.12189639188204779,0.32761839317746577,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0596474757539933,0.23433233795001485,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016409777147967507,0.06363499571656236,0.7967062268837647,-0.1088891186321346,0.14170867292806963,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10369553515137765,0.14161520008652462,0.9738068609884574,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026972463857610197,0.1259103432587964,0.8305418024135174,-0.22094814649162037,0.2748930742068408,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03228714659063402,0.10313240068230234,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10914882862928199,0.1182986675572583,0.357032803377319,-0.12378420217037178,0.34208185942893576,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08158360334133821,0.24064544955772907,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11066442382204483,0.07165082680956038,0.12367058060987524,-0.030417843566756086,0.25174669121084575,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09034622178417297,0.18886481876578132,0.7255706347976272,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059831457315006865,0.05630753404897029,0.2889455741758562,-0.0510394834462918,0.17070239807630552,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11999762775182377,0.14434846213369648,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14079272203337728,0.09641490381511553,0.1454067537491596,-0.04905063143501112,0.33063607550176566,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09598537190417705,0.21083743422534892,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06470438164311312,0.06565998090045659,0.32531062485050843,-0.06458176053585968,0.19399052382208593,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.16633754578239407,0.17661631970623956,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16235920110678145,0.09878104938881034,0.10144814302437674,-0.03214315208810134,0.3568615543016642,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0915399311804066,0.2325817868612614,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07530809167779927,0.05891671551804815,0.2023013784683999,-0.04070039255755781,0.19131657591315634,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11218662279648478,0.16015328869830228,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12903205320307348,0.08790299489257827,0.14332861945627554,-0.044051139021253904,0.30211524542740087,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08896016461017996,0.19934264335978036,0.7615412190387651,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12633244364936685,0.06005057323181409,0.036348364756860936,0.008091365258752425,0.24457352203998128,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09327672226371585,0.20576044090197596,0.4572635807289415,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07545662266597322,0.07105609760391036,0.2892414797100051,-0.06445460806419351,0.21536785339613995,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07424952530485923,0.14600973765877348,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18463756680059584,0.06869728656227865,0.00765358625278457,0.04937089392011937,0.3199042396810723,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06170318843369821,0.24661629885579903,0.17308879679374334,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08304373939775402,0.044354416624611835,0.062277962992221395,-0.004291214638991431,0.17037869343449946,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0660916885269797,0.13568137273814698,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09242898036046235,0.0564856347035912,0.10296720129844904,-0.018792645037653308,0.20365060575857802,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06030691579254198,0.14201938388544957,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18150941654347935,0.13723831939003703,0.1871221662729452,-0.08871626171193758,0.4517350947988963,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11632405388053456,0.2491057648907382,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08770661537666391,0.05491613334531844,0.1114439641529429,-0.020424622650438484,0.1958378534037663,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.12821101539350993,0.1617545150197481,0.7040249164444842,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09622149223556573,0.06957883632680457,0.16786445073502537,-0.040780974147000326,0.23322395861813178,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.039173283163356394,0.13919907256129646,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10152256252079885,0.0559412690146049,0.0706928227686386,-0.008627193240767037,0.2116723182823647,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11661467595870446,0.19089872102717176,0.6153066087033479,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05086983723283895,0.07936166538923671,0.5220889343072311,-0.10539526388907705,0.20713493835475494,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07183500748746291,0.11538465410778344,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1421102302708478,0.06788851316913344,0.03728139640214342,0.00843605239970227,0.27578440814199334,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07070406454377048,0.19556763405133923,0.4631727895701855,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13013989577922497,0.06514942632355719,0.04679437391781399,0.0018590483127074175,0.2584207432457425,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04143418345138064,0.17929138306161999,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05199493726373639,0.06664242719450364,0.4359702137056818,-0.0792256662037332,0.18321554073120597,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10693169278229611,0.15343884609372313,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09262435648770984,0.06538993134394094,0.15781465337251835,-0.03613005137029229,0.22137876434571196,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.051025360228209575,0.13913717352233582,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03137420911525868,0.14812851919244185,0.8324435468020679,-0.3232036952850102,0.26045527705449284,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15195038216139573,0.12882105258510157,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12147400632931912,0.16483457321691244,0.46189092103455354,-0.4462162576334576,0.20326824497481935,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14125492393244932,0.02106401197733156,0.9370609591482926,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023736663590453642,0.06437612994781883,0.7126695936632585,-0.10309139778955714,0.15056472497046444,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06504444587944565,0.08788471910269434,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1562084448327886,0.13383285463430572,0.24431638585469231,-0.4198738984097613,0.10745700874418415,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2246722618009412,0.07810780740315142,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10662114376794754,0.09535219464243345,0.26463086784652473,-0.2944754618922546,0.08123317435635949,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20659750188985077,0.09558675560654743,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014012995801356556,0.11040430752671235,0.8991088017669885,-0.20349564137464823,0.23152163297736136,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0936422102385419,0.11426794197954883,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09796558548919297,0.10069159267414138,0.3315898811237199,-0.2963391054022168,0.10040793442383085,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20351830897636972,0.11551855442175991,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03649785539714028,0.07073373627204542,0.6063469774993065,-0.1758511009684427,0.10285539017416212,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1616527263823701,0.11428194287994471,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05273513870046125,0.06498730711240225,0.4179179300411764,-0.1807672863622457,0.07529700896132319,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12699229134832316,0.06936059238439658,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1803326453105067,0.14007032819583348,0.19920621363474034,-0.4562866083141701,0.09562131769315674,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2139783973826697,0.038325718765519365,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05015128834090971,0.09040335749471519,0.5795930764223061,-0.22825585260397588,0.12795327592215647,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14577217719434354,0.09796680617924833,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15777652581338922,0.13893058871051764,0.2572599426638107,-0.43148507658866875,0.11593202496189034,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2161251867922367,0.0626878924000146,0.8656758901506271,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12019144928990749,0.08980395336488206,0.1820673721031321,-0.29711512144542496,0.05673222286561,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1439989387607934,0.021020595094363707,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11664268854453702,0.06815017864862474,0.08829832203966304,-0.25090604124549154,0.017620664156417498,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15345465253277896,0.026400304010816326,0.659371665428829,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2057691617034207,0.26766596946343185,0.4428115270832711,-0.32156225806295863,0.7331005814698,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.01720671873169036,0.23362582264838197,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08302155447765376,0.14159420447650403,0.5582135718562764,-0.19593461252020883,0.3619777214755163,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.019278880800026484,0.10426007365314596,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07158213628924276,0.0689142031739265,0.3000053932089969,-0.20735070139531311,0.0641864288168276,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09686708531346869,0.013848462618654403,0.8872737746993358,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03467723107380129,0.07482920166310335,0.6434933784395136,-0.1820989942216935,0.11274453207409092,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16560952290567138,0.1347776064350295,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08841269243766096,0.07998266734048506,0.2701175113066139,-0.24598735017211093,0.06916196529678899,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12010823130439723,0.02753063337451597,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053876553110185535,0.056551691434184675,0.3417231418324562,-0.16528960944289564,0.05753650322252457,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10945279835971261,0.05662019679893044,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09972356780999417,0.12844318571834124,0.4382922964236734,-0.3527707804233372,0.15332364480334884,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12132066287611103,0.009711836594435133,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08693695297174131,0.10176259206241456,0.39380245917686163,-0.28742045955628404,0.11354655361280139,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15662718558023955,0.08594381664078551,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1253737691347949,0.07158514727246908,0.08118273405281165,-0.2664043880851568,0.01565684981556703,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.014291202192540937,-0.11666840171619028,0.6405850327149293,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16853869398467416,0.13514212476627072,0.2135943042428335,-0.4347835538228568,0.09770616585350853,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2190569009546145,0.06016198118464481,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07770152461445919,0.08112421738192775,0.33914329921651043,-0.23752516157213677,0.08212211234321838,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12767705253740466,0.04733634779999156,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09636474482095364,0.06012382679997151,0.11032837207555905,-0.21481530098158047,0.02208581133967319,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17354723780545167,0.07560251281939404,0.7002905874282662,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022621794757779277,0.08624785153482971,0.7933290242904834,-0.19253955491546426,0.1472959653999057,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06136111773581447,0.03358408647564802,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08803399621442742,0.06761829227056589,0.1942164623996247,-0.2212494742099854,0.045181481781130545,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17255071108497386,0.08524477150392885,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07169389481438858,0.07937838162984974,0.367349037271121,-0.22807804318983166,0.08469025356105449,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11432013957821446,0.037074985412214545,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10416283230236664,0.056381333267920476,0.06593587398795736,-0.2152402642975303,0.006914599692796994,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16851039891420605,0.06605528565566623,0.5947207955047311,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1262818071750796,0.08944304393668792,0.15931144988431342,-0.3024944480345447,0.04993083368438553,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1647284987131878,0.02709822403235292,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12230003228200646,0.10428433711921928,0.24208125813054046,-0.3277516541774324,0.0831515896134195,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1663491718730802,0.04785675283939085,0.8491564414671808,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10031883213262037,0.11139576066012936,0.368742996109643,-0.3197807411030362,0.1191430768377955,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.18613640288362313,0.09571532051703555,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13319208480318603,0.06715070241563957,0.04847781434135377,-0.26548635932053966,-0.0008978102858323844,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07315753474725598,-0.0671956560714098,0.5221396068407954,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04990566282727503,0.15946164503346344,0.7545860156060213,-0.36406265425336226,0.2642513285988122,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14830772216066143,0.0943789287087818,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06736538640752837,0.08057037924927761,0.40394454840081206,-0.2260979012872047,0.09136712847214795,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15777897621644119,0.09323407823880421,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06996702863728915,0.15080401573181146,0.6431058936811282,-0.3670675374608135,0.2271334801862352,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1429499990080078,0.06236632327322359,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07308086886809516,0.08527447220592566,0.3923137956266385,-0.2410809646155035,0.09491922687931316,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15565961741694342,0.0807717750986814,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04805164605273605,0.06169029971907192,0.4368120268229334,-0.16958832627355147,0.07348503416807936,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10615142324537209,0.05346918965774434,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08839004466230123,0.06825259246615359,0.1965762325034332,-0.2228551638556845,0.04607507453108205,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15545569363956735,0.060168420509967784,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049237913260937995,0.06367531175772949,0.44014245558842346,-0.17468528567283398,0.076209459150958,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10742620306107396,0.05359895677972001,0.9319420678743413,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09835188497497659,0.0708223668844666,0.1662350462497331,-0.23787974260763484,0.04117597265768168,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13768831121306385,0.03304643024493246,0.7840604855201315,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0634223673856839,0.07085017007260594,0.3716165437268657,-0.2030050003590586,0.0761602655876908,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12360491325201353,0.0579477741482649,0.915561182973695,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0855636810631095,0.08419421723287498,0.3105481029357294,-0.25143555561829667,0.08030819349207764,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1814655813454227,0.08226330689645289,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09934906983335955,0.06128334914884333,0.10632793085799688,-0.2200840126409223,0.021385872974203204,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08792625574277611,-0.016353499036060596,0.6896374207352632,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09302981905017202,0.059578248734094535,0.11975786090656804,-0.2104055263734624,0.02434588827311837,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11897920992084537,0.016005821071782136,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09334734518872626,0.07311970327435863,0.20299040323355594,-0.23740120835952314,0.050706517982070626,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13625927763056997,0.03490465148458222,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056447902480428816,0.04482168001351325,0.2091395073541532,-0.1447515452827664,0.03185574032190877,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06934649900326746,0.007303150424258276,0.8226706686705988,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020194089084279502,0.07909036754713523,0.7986920896519258,-0.1760108180172921,0.1356226398487331,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08990072215320008,0.057942328821616096,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07414819933573069,0.06770796582451452,0.27458613168075074,-0.20754034410224212,0.05924394543078074,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14490569822616314,0.06926613698340958,0.8709804306040525,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06589523116420815,0.06375143474030555,0.30237289760946057,-0.191492574230047,0.05970211190163072,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,-0.03678814759270968,-0.11026761311260423,0.8904632102898862,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0945702830481833,0.04274400416271003,0.027895630307800595,-0.17878067575072415,-0.010359890345642442,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.23006881310428354,0.1320979029735977,0.3947157101306972,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10694145934083948,0.13728948273207248,0.43679362726804327,-0.3774168507147376,0.1635339320330586,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14178303181940932,0.0467018645199894,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15029619479560105,0.08165296666399503,0.06693063934381327,-0.31116152603429587,0.010569136443093763,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11085113797425726,-0.036834183795550354,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005745413301224099,0.08253262171337074,0.9445602154036923,-0.16834376180401806,0.15685293520156984,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17073280347418873,0.16074695902891456,0.9929703337140127,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.23396440544867952,0.1273594388920183,0.06746677870703265,-0.4848765175345337,0.016947706637174653,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.27479082635416974,0.040548288312947274,0.5990506592577463,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019790574472299004,0.10704467015588272,0.8534814726095172,-0.23068035625846384,0.19109920731386582,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14445787983372754,0.115249686484622,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1656407911864766,0.10920364292106573,0.13065957440888015,-0.38078398694148907,0.04950240456853586,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20302660065006398,0.053692652006273586,0.7355856040125466,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09642943744136166,0.08078940575513135,0.23384187378987334,-0.25559345864412364,0.06273458376140033,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16375563036901356,0.0620542007344243,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12668579311611775,0.10018675182707522,0.20730453200977905,-0.3240647209964931,0.07069313476425762,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14256029747919446,0.007098317623647646,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033636359827697145,0.054406467934633836,0.537014598913275,-0.14082308975813035,0.07355037010273605,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1278299513056976,0.08292958542574591,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09797870432014347,0.06484130254743618,0.13211820159822255,-0.22572320691935135,0.02976579827906442,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.03219967763028336,-0.06957187273190482,0.7380396089280018,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12644509027207115,0.08746852075058005,0.1496197575124892,-0.29876770313440554,0.04587752259026323,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1696790343759547,0.038828939715531564,0.7663649588223891,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05152132049428525,0.10083985150131874,0.6098851709311293,-0.2501869266145511,0.14714428562598064,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14167175095243506,0.09375830246895034,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06246653692910074,0.08837484998385865,0.4803685918403129,-0.23657471813364409,0.11164164427544263,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11339535381220016,0.05847089901474906,0.938972145291407,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07010745873752905,0.07723927499373612,0.3649845688754738,-0.2222773316049024,0.0820624141298443,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14151715373437435,0.0678332091002842,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04132662819623365,0.0750523928210353,0.5824055619895843,-0.18918810249017665,0.10653484609770936,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11861950816029326,0.07956805659293763,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030279692892597423,0.09577224872342915,0.7521590188961678,-0.2189615637885704,0.15840217800337558,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20498051125334774,0.16730205508838397,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09880136294839542,0.07834254009451999,0.20850686664592377,-0.2531447894921712,0.05554206359538033,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1485874111571228,0.04564250539699226,0.82185729615414,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04058816899239636,0.08204357631520114,0.6212636590940357,-0.20222304423535098,0.12104670625055824,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16389394902379958,0.12478292664466284,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10583299890046012,0.08429887287502655,0.21056243816525072,-0.2719110565893231,0.06024505878840285,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14389551414206053,0.03234865640802013,0.8252886794984905,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12758349064164956,0.0830774748174616,0.12595304993380563,-0.29125525972727034,0.03608827844397122,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17158678172656847,0.035094136851123274,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06337973673505165,0.08399853233375094,0.4512841698842164,-0.2288660905014408,0.1021066170313375,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12160173587694535,0.048619315391715566,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1451562594523024,0.13419969223363004,0.28051954413481944,-0.4095444234749218,0.11923190457031704,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17701738408009932,0.03759597148906741,0.876035315676277,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025200691006157863,0.08475689416685218,0.766477928031775,-0.19218110105077907,0.14177971903846337,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13483388786969122,0.10412898964973157,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1466544319462632,0.11688679180864929,0.21084472688623565,-0.3769342766346001,0.08362541274207372,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19841102840898728,0.05033868600036998,0.8252886794984905,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.092295897139167,0.07556857244508934,0.22317628592863867,-0.24117430210439608,0.056582507826062084,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12498182117733667,0.0228175826570232,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11303221633925296,0.08997867835918216,0.21028682478474317,-0.29030011596417066,0.06423568328566472,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16119725841431473,0.04222561667210149,0.8251393055567431,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11123351009059794,0.07297109039827018,0.12876581027224276,-0.25499458953883053,0.032527569357634636,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11484902566035662,-0.006572794029947974,0.7302718857033121,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10988490298605076,0.07465514257426185,0.1423857972685634,-0.2569637505715873,0.03719394459948579,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07635412346583946,-0.03845879754379048,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09273517364813823,0.07792216550875192,0.23520795388773685,-0.24625041599057096,0.06078006869429449,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1459204961762589,0.04863239334925708,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09264499090675303,0.07001333911684304,0.1870390117956633,-0.23057897479376266,0.04528899298025661,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10131628798548276,-0.007583472676564471,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07127833712386399,0.09172463616627313,0.4378869449012992,-0.25198596579282534,0.10942929154509735,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1317805906411644,0.050979412802277135,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10046599536096353,0.0614208624617291,0.10324139446646587,-0.22147185452993823,0.020539863808011163,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09156168212442269,-0.019158728489458172,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08712863845289225,0.061601271252841185,0.1585689761075702,-0.2084899227965583,0.03423264589077381,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11436695771368774,0.02348802320096063,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07918466995496236,0.06574629979992802,0.22964764477985444,-0.20871211674762846,0.05034277683770376,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11036046758620885,0.023228440806779698,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07859114786379304,0.11465463664776535,0.49372940870869864,-0.30447340120913113,0.14729110548154503,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10032532960902227,0.013442604932012452,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07833311425238387,0.06837757986656516,0.2531274329242502,-0.2130444723809746,0.05637824387620685,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1395240185837142,0.07419109114486544,0.8627417615082431,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06943687899377209,0.09916739793745125,0.4844958565530709,-0.26480756751918816,0.12593380953164401,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16928797726891653,0.09406806743725123,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03725031685454691,0.07982656410856791,0.6411893302517044,-0.19451743404104446,0.12001680033195064,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08249817095398868,0.037317087034190295,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08246752102863707,0.12833782210916336,0.5211220510637067,-0.335307155735342,0.17037211367806782,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15502049485848582,0.06977049491592481,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1441442837450879,0.08965716491137775,0.10923756587589295,-0.3207787664913319,0.03249019900115613,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1543763024510209,-0.0019007940213066304,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044723539927653065,0.065753413930277,0.4970659543921294,-0.174265002340104,0.08481792248479786,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1273702129130456,0.08200781242585349,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1291013757921774,0.07182848802046457,0.073562906555156,-0.27061140279872486,0.01240865121437007,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.150559276314692,0.011986040194281964,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12621551009936682,0.09927047586009285,0.20483247613097738,-0.32178927347737674,0.06935825327864309,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16767975032957144,0.04512907664141703,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09557452887559854,0.032045389038497275,0.0031604714528745623,-0.15870747226960513,-0.03244158548159197,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.105086274692161,0.003806032273728089,0.09089790722071839,0.868683601359903 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05366060619459894,0.06563374656158397,0.41442721462344645,-0.1829663107198627,0.0756450983306648,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0900381150492104,0.03568777372758538,0.9266313996019341,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14783145703734038,0.11535485233417847,0.20126830382431068,-0.37509321235223825,0.07943029827755746,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17060405408255352,0.019652698168886373,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08083062590614049,0.07233373560077226,0.2649354581229559,-0.22333604625458822,0.06167479444230725,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13978195574917154,0.06091608068378919,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11690522664401262,0.047925260894639804,0.01545580429389783,-0.21132326536931736,-0.02248718791870788,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11260213319575489,-0.014883253955654763,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.088288358980816,0.07087000828772601,0.2140861758097867,-0.22791007542141614,0.05133335745978415,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1509144194971464,0.04711289893500551,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0709949095774015,0.040172881579735926,0.07848681196731927,-0.15013990780790296,0.008150088653099963,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06228141032578441,-0.01230781233363727,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04708833145124788,0.07351382826284954,0.5224475851240364,-0.1919186642276616,0.09774200132516583,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11102809034638107,0.052688760180824246,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054016422825395635,0.09969320109200654,0.5884513559713809,-0.25042300143637286,0.14239015578558162,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.026953415704355284,-0.022405212987118263,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009690162409673464,0.05707642081944617,0.8653329686231074,-0.12213699338425446,0.10275666856490753,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1259505193529081,0.10601642964680517,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08986573170869361,0.10616035118328544,0.3981298362050718,-0.29901330778869084,0.11928184437130365,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.04626422123587793,-0.04064045627579127,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02469357902129357,0.07604564042153715,0.7456814863821135,-0.17451186040730787,0.12512470236472073,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1171555054870571,0.07840230085964238,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04413835527800869,0.12057643099567715,0.7146487187152115,-0.2816871952548441,0.19341048469882674,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.029945107554049,-0.01080792604829591,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06885054829295927,0.044763782519929504,0.1253729272069064,-0.15704012666060746,0.019339030074688943,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08411421736156541,0.004776466170474154,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14127509145100928,0.06860553983714517,0.04057360867635207,-0.27643555581143375,-0.006114627090584773,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09874884508622807,-0.05689976511190705,0.4857817581793103,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07359839901874618,0.05681229146753472,0.19643056853088048,-0.18552486609938634,0.03832806806189398,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11282738775571449,0.031400978726476576,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11282825119644752,0.07278657216842879,0.12245727713543174,-0.2562258094233979,0.03056930703050284,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1601328658882102,0.0377934974159188,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02425066083316978,0.11463948064378314,0.832650452911012,-0.25010305518255876,0.20160173351621918,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17956329737041976,0.15871582304655804,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10369202576856666,0.07004024202626835,0.14008900071238864,-0.24167901134813935,0.03429495981100604,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17760055688363582,0.07780033246864702,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025584578937072045,0.04170381647270916,0.5401504115506144,-0.10774568740489585,0.05657652953075176,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10536597422195147,0.0767315888138658,0.9481163084809376,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10244143033345034,0.0750276421715163,0.17343841558100195,-0.2502541431237283,0.04537128245682763,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1315623945196611,0.022367225424613058,0.7876167865457628,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1441638462950254,0.07084110043649904,0.04297027248840221,-0.2837286110870448,-0.004599081503006031,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19608796362856176,0.0461974174181099,0.4970268279685195,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08118779625969803,0.07467295856418486,0.2780424574071925,-0.22830174330625114,0.06592615078685508,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15864681393682264,0.07159960770306466,0.8739920503526474,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11097987245685645,0.06430663102154649,0.08569927915955829,-0.23767101330290136,0.01571126838918846,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14072582899635827,0.025704350849359323,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11102060689850476,0.08562332716019601,0.19603495685025077,-0.2797079853015928,0.0576667715045833,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1684622395457607,0.04781221312669944,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011835217014959157,0.07101000493382277,0.8677732567251556,-0.15173274225671818,0.12806230822679987,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09611841797717438,0.08092627279907343,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17085886798641228,0.11234452631944838,0.1296425133044587,-0.392189949728986,0.050472213756161455,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.22415583254250887,0.05249214510912933,0.7324571321073261,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013016157488939355,0.06179013253642345,0.83334209813429,-0.1347495193477635,0.1087172043698848,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15300123851972078,0.14319661599043995,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17553746609124143,0.13550950075281482,0.1964572439951311,-0.44250609705714994,0.09143116487466707,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16356374030367143,-0.014770506060528241,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062869081750166,0.09833579238504664,0.5232305874946842,-0.25660141580895257,0.1308632523086206,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13527525687926445,0.07522971826581164,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10031119451484992,0.10368534716382045,0.33430984128593577,-0.30458274027194776,0.10396035124224791,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16115894200313632,0.06353193275500929,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1288274126192773,0.058291546077975924,0.02806595888439017,-0.24366817409260264,-0.013986651145951962,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16817149678386742,0.029373027979263562,0.3964191843848562,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020761735209961524,0.06797512341092674,0.7603079981979096,-0.1131567394057516,0.15468020982567465,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.010607893031681784,0.02536065433411552,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17271199479964938,0.1425286760905133,0.22681738235660795,-0.45350917372717464,0.10808518412787588,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.24139213431222745,0.046626520346446224,0.842579263271115,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14329641567597207,0.06897421033319576,0.038838396108870785,-0.2791832014903268,-0.007409629861617306,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12789145774333316,-0.015747539286238874,0.47377644413826986,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16657229191482073,0.12084464695881045,0.16939058418650074,-0.40464954685948573,0.07150496302984427,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.24194179474653524,0.0849407080205837,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023757827978042607,0.0806753492163649,0.7686458907327132,-0.18269714524611344,0.13518148929002824,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,-0.04104075644051979,-0.07089741380675756,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054528860901587727,0.06800518226578765,0.423459099233936,-0.18850655476972258,0.07944883296654712,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07971736592758076,0.01117498180274583,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0629407440530828,0.07351559970353219,0.3927842144917193,-0.20777456676261014,0.08189307865644453,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11623865381755404,0.05581676546229265,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07859748931310871,0.07814343514987887,0.31554124604353645,-0.23254865720199985,0.07535367857578244,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08599923098132731,-0.005318811201941276,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019557848228430548,0.06760401251751995,0.7726067907221894,-0.152745193538826,0.11362949708196493,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11840029984281868,0.10412353217600163,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08197238350403344,0.07234586330929271,0.2583426817212007,-0.22450169677306955,0.06055692976500268,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14400616721411472,0.0465942428338099,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11009002311765892,0.09952794395011971,0.2698048824652787,-0.30617102697054344,0.0859909807352256,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14820442327340194,0.030266835671433092,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04770586713479843,0.12197777069134573,0.6960754892882967,-0.2880155005467248,0.19260376627712794,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19004992641235016,0.14331815618314606,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10666998247147742,0.08911965063623357,0.23253989925872554,-0.2822455029356477,0.06890553799269285,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13296274966139277,0.022830707347349273,0.8436479526123232,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05661961041884255,0.06079849258735112,0.3526713473224521,-0.1763993324358533,0.0631601115981682,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07421980617856964,0.012176864213982634,0.9092254482122848,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052975045686535605,0.13112893468666698,0.6865859717816373,-0.3113134793671006,0.20536338799402937,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16641522428187158,0.11914622645744587,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03758242632007783,0.06889514678252957,0.5859258419697827,-0.17331344823770659,0.09814859559755093,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15941988015726458,0.113387123000429,0.952608653969109,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03308499155996169,0.08390165392873421,0.6936945685800617,-0.198380484205811,0.1322105010858876,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1347591824341989,0.10127421921220289,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05015616703140418,0.13975000093347198,0.7199927178580536,-0.32547905007227074,0.22516671600946236,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.18879927007834105,0.13650439000782505,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.129771903117769,0.10399394905900777,0.21331721203807946,-0.33465142857381003,0.07510762233827203,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.05465909091489869,-0.07660322012190966,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05860310320197066,0.10115277731542088,0.5629063708256171,-0.2578852076173423,0.14067900121340096,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12769682722213702,0.0755091618701061,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032583551659809494,0.08271222453148196,0.6939834652366854,-0.19553573748177588,0.13036863416215688,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1084332962517661,0.0761198838678445,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1572316511359244,0.07778241865230151,0.044369111546490834,-0.310471576790294,-0.003991725481554825,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16197538241599907,0.007564023062165383,0.5034452685637203,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06241863062931233,0.06871924207761626,0.36464303167581646,-0.19780310091779124,0.07296583965916659,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.022275442376225692,-0.04192306365482969,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03009653994163817,0.21459376831658783,0.8885834707112481,-0.39267680231868135,0.45286988220195773,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.38399782732256427,0.40610725378926954,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19208300915183868,0.07424291588168962,0.010277401659287337,-0.33834972478240355,-0.04581629352127378,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16333887687862106,-0.0249000727936639,0.20653674524410856,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16961615889406753,0.0736838946377227,0.022213706550468074,-0.3147815411468721,-0.02445077664126294,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16775968971562563,-0.0005744896360950451,0.34711102873546373,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05935825674760117,0.09626309570213486,0.5380788208448392,-0.13029063672015334,0.2490071502153557,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09747771114250016,0.15631533670329986,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16007437100210561,0.06720718728063153,0.018025081046257576,-0.29247992692034575,-0.02766881508386551,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16008081912071234,-0.0021989057445247484,0.30508122248441927,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02896650504368572,0.07119317282546031,0.6844723658447137,-0.11129188110447266,0.1692248911918441,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10836635092924597,0.13106311634646692,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05809199485213264,0.0872757213400413,0.5063102531730651,-0.1138507819515002,0.2300347716557655,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10998938556141401,0.16504202839046916,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05781204658169038,0.10593036208446355,0.5857518935714559,-0.2665065188238869,0.15088242566050614,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09816801242830868,0.03283735049124498,0.952608653969109,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016022906020529453,0.13888446846151312,0.9082514885582051,-0.289640594829171,0.25759478278811204,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13101432954657127,0.10202993556015956,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.103243665145808,0.1096177411578866,0.34723572491726507,-0.3192026800039483,0.11271534971233231,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19052297679146923,0.07730339116045555,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025697732013867894,0.09513959447662179,0.7873161065423804,-0.16173774038453392,0.21313320441226974,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0706254558939565,0.09861239602563643,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14430607948732727,0.12436134088472232,0.24707268151078415,-0.3893116085213447,0.10069944954669022,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.21494035546556337,0.07575684541800462,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09474339263071609,0.1006406479217562,0.3474651659066027,-0.2930165457744462,0.103529760513014,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14442074081435616,0.049207692564189255,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03323439111974631,0.10668660161134888,0.7556859300506575,-0.24341873846334372,0.17694995622385107,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17421874029426598,0.14748265438176061,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16976877683057445,0.10272623224142749,0.0997409171822002,-0.3721507606281954,0.032613206967046476,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17746124464301444,0.008032175673492363,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07944446153916504,0.09491621950164775,0.40344537277367887,-0.2664398606517119,0.10755093757338177,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17977256557639568,0.09895856818110126,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07310103085190824,0.14318485134340023,0.6101551829417384,-0.3551909472477566,0.20898888554394018,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.060967775959663795,-0.008041609933852984,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08790936947908908,0.11493148722650094,0.4451074529993059,-0.3143370489353386,0.13851830997716047,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19626246579427062,0.1018453399441879,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10379421876444847,0.06851050161908669,0.13111327571786738,-0.23876744737517602,0.031179009846279082,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12671960828354872,0.011573609935505127,0.7360778123788349,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0566646551003992,0.06291551958595032,0.3686982451813381,-0.18061515330944128,0.0672858431086429,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1252776053640268,0.052130207465816085,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06796416107167916,0.10663438719661832,0.5245128591073986,-0.2780456402714205,0.14211731812806216,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1346559091263856,0.04859143269736208,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030893278590316386,0.10784475486392514,0.7747777120655045,-0.2433593153104616,0.18157275812982884,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13712114514296891,0.0904493517087269,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0465379512491401,0.12757387420910188,0.7155946112911571,-0.2978725245108861,0.20479662201260587,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13321938405453354,0.06865031329159285,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0997262999017794,0.06276184967504796,0.11341303663222567,-0.22337405147308506,0.02392145166952625,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12656250417438333,0.009878616438975169,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055756527503185285,0.09614011125431267,0.5625034622738931,-0.24516312807278295,0.13365007306641236,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13207208038581267,0.06149989341804734,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1072292985632748,0.08854069999537226,0.2270837215520476,-0.2816642225443282,0.06720562541777862,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11988146347411445,-0.004952687612057837,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016721735847682367,0.07609057042902004,0.8262481092666596,-0.16662853429353644,0.13318506259817173,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09927906512918455,0.07576313382623523,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08454981664487647,0.08642601249959067,0.32893628683624276,-0.2548185735119402,0.08571894022218728,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12968323000254697,0.034779948701281496,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017023427776583902,0.05895571219610723,0.7730276825384994,-0.1331726696022566,0.09912581404908878,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08474681896192711,0.05961912119555043,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06049790554228493,0.026780649242245987,0.024799661738970136,-0.11325873208847892,-0.00773707899609094,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09461247333111483,0.02529514920853576,0.37213556688836474,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19865760235749683,0.14425083212592185,0.16977072640202856,-0.48284761821917443,0.08553241350418075,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1779387160130496,-0.041104564157601,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07449398923836834,0.0785654962697223,0.3440134173462739,-0.22927666398635474,0.08028868550961807,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09796391692908717,0.0016756024163885647,0.9053547642872083,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008565568249298902,0.09480149020479281,0.9280839248447386,-0.19533493801967497,0.17820380152107715,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.076503639684012,0.060529767848013824,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10322921256459265,0.08827968013439909,0.24345021211805123,-0.2771498986910913,0.07069147356190598,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12875226512466884,0.005849814226817652,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032789497228597905,0.09901239303892242,0.7408145227485747,-0.16227581458652585,0.22785480904372168,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.093504017388159,0.12313099359006215,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11952148406907044,0.07241166499926839,0.10015949099875245,-0.2621804339096418,0.02313746577150093,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09550030492219293,-0.037109443079623064,0.6801249269017082,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0640714226643548,0.07741427720914618,0.40871210074427644,-0.21658606915722656,0.08844322382851695,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0828437660776911,0.009384467938706589,0.9253726913029282,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05673934786550759,0.0608426839483564,0.35200520995682816,-0.17660613172750012,0.06312743599648493,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17090922645965198,0.10845867633361299,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06367674469620818,0.06369316570737353,0.3184635924589602,-0.1891592913539491,0.061805801961532736,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06562643232559434,-0.006829587126921158,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04606889987409761,0.121117973162163,0.7039100893561896,-0.19215610804757405,0.2842939077957693,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13166633385462662,0.2117905979208715,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04043570435198411,0.09217076371918072,0.6611512555190303,-0.22172490812482099,0.14085349942085273,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08652435644527759,0.07417689152449623,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033326931980576464,0.07810952684877488,0.6698871526346457,-0.18695931342237895,0.12030544946122604,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.050544374074549016,0.05061854138921305,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01060183651861641,0.1203361238686876,0.9298469817504651,-0.24728903754615889,0.22608536450892608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1634648189157226,0.18954564468216775,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031158828777966698,0.0608816021185784,0.6091236840232038,-0.15090588008936753,0.08858822253343415,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1560416637904303,0.10600362028739313,0.9546345120979649,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09526110997938857,0.09118520797953227,0.2968955862454121,-0.27461183990102705,0.08408961994224991,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0798624668973259,0.029510155749829695,0.8843360296870468,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05982402065043024,0.08743174054678945,0.49428629145812275,-0.2317921153978349,0.11214407409697441,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13663114642382954,0.08022019761193998,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05949174279297782,0.06638991906171296,0.37082810788100606,-0.1900730147667109,0.07108952918075527,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1327213491115249,0.06835276249586751,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019009155370747818,0.05379589352532121,0.9718325518597084,-0.10771119973052423,0.10390936865637468,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0927678864314953,0.0893070939773538,0.9975956028271519,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030113735114483592,0.10395698315608776,0.7722394295673103,-0.23458506574610183,0.17435759551713464,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14497113468854253,0.1285751388411305,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019393705627654544,0.07584714488653702,0.798339484026271,-0.16857624410391828,0.12978883284860918,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12974942172526016,0.14888355831373465,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039715675518504245,0.10466913268710594,0.7045951318851236,-0.2455877216941407,0.1661563706571322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14916650369194542,0.12309111936519342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016720380734098577,0.08679899514382164,0.8473598016262667,-0.18744393864936362,0.1540031771811665,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11358869074228016,0.1198673407376546,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04604761983560219,0.06349787829380238,0.4688324087271434,-0.17094058299060313,0.07884534331939874,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10926612320444207,0.05617954911702521,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0958613497970348,0.14481024022647002,0.508427830816109,-0.3806862995912485,0.18896359999717888,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-6.984673028851706e-06,-0.055979985846765945,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21689923139384196,0.11639954746692227,0.06325755944037145,-0.4458436431390769,0.012045180351392959,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.005682556490099073,-0.1671098382844003,0.5832038406941563,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05496360845285847,0.05777419246596341,0.3420935241931885,-0.16859874532428631,0.058671528418569374,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05900177224892376,-0.0038059592785672732,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008394837487255898,0.05994654075148998,0.8887113459164837,-0.10951305654825788,0.12630273152276966,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1415442217725226,0.18440944820189129,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018460264181676758,0.07064593796444557,0.7940122947564097,-0.15741263179338572,0.1204921034300322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09241948376184292,0.08377316796509138,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006610074786579314,0.050786851297751234,0.8965212383565309,-0.09328177228491014,0.10650192185806875,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09570499347308707,0.1375006488576393,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02567404779660273,0.11647638913844818,0.8256726750107136,-0.25476959819888456,0.2034215026056791,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06866332527658761,0.061981271601488454,0.980597249022118,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05327963834784658,0.10050078459870057,0.5963558341037256,-0.2509530272106568,0.14439375051496367,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12084955812434721,0.10962054355161617,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07691840687899754,0.07174911693747765,0.2844505516945563,-0.21804059960194513,0.06420378584395006,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.0030686011882354726,-0.05358522381123115,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11782038944549222,0.10954360976706184,0.28287922521515685,-0.33327996677500427,0.09763918788401979,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15862084865167336,0.06169918796792515,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0005646026142393148,0.05330066098507858,0.9915544762902182,-0.10540082183002925,0.10427161660155063,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09280628653706252,0.10265513294360318,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04042576011182438,0.061610043418925384,0.5121628095530608,-0.16160557098825934,0.08075405076461056,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1503076625587817,0.12091459561190881,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008374735105987968,0.0630571448568399,0.894419848049756,-0.11565135648758784,0.13240082669956377,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.03189501114213744,0.06718461608646568,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04319597775870326,0.056757042140849624,0.4471377381476398,-0.15483049789314746,0.06843854237574092,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.168452749304407,0.1376217442238509,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014815545295229288,0.06413156632429404,0.8174381682423075,-0.1113238087309401,0.14095489932139868,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07655942340492147,0.10996805319785773,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033364175811287644,0.06344984618779104,0.5993413759064636,-0.15816266538374502,0.09143431376116971,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1412556544927532,0.10757764854865141,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014765662504391524,0.07817172091590965,0.8502923634199336,-0.16852037246399396,0.13898904745521093,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11744569261551623,0.09894547701991518,0.9831931217519931,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0530590289537792,0.08338609298941646,0.5250004660196698,-0.21706980410409077,0.11095174619653236,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09459865642088977,0.050436672450989935,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0849429806793682,0.09886060249010263,0.3908176368163906,-0.2793903215361523,0.10950436017741588,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12708024767160778,0.0578565932770779,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00432500481199774,0.07354522475598052,0.9531396458440292,-0.14897993333063228,0.1403299237066368,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05662411604905898,0.0699194556772778,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06126896332152366,0.11659635755171975,0.59958863380364,-0.16806255103768228,0.2906004776807296,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08749413882953955,0.1657276890353169,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024593817854432133,0.056593694268299216,0.6641483734775901,-0.08671941595712909,0.13590705166599334,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1655119579396263,0.17902248493325676,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02526225660893527,0.07805246368287949,0.7463941114282362,-0.12825788820280684,0.1787824014206774,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10474833014763985,0.1313146690359003,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10397284438415322,0.07756999362847948,0.18100817012862097,-0.04859833777959671,0.25654402654790315,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1976717985701108,0.27483492030805623,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008894060028320732,0.04845182775742184,0.854462867787795,-0.10419318657395156,0.0864050665173101,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07375337805820746,0.07494234652912879,0.9834313824125731,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03434284056101568,0.048724664454868026,0.4813899584191109,-0.1301786052513702,0.06149292412933886,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11672772259359078,0.06730846662416591,0.9396519533333579,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01688900382038637,0.05967251004207884,0.7773254479829854,-0.13425791122810338,0.10047990358733065,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0720787363044123,0.06490956371497254,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03838399256913371,0.05401953332378006,0.4778398418132851,-0.14463415031205323,0.06786616517378583,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09651630179761161,0.050785057023308766,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00965633381437015,0.058550064671520075,0.8691003642740872,-0.12481752134111629,0.105504853712376,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0870554886008042,0.07013474439276758,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027644187261712406,0.06443222631125937,0.6681605901641777,-0.15437490461659809,0.09908653009317327,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13560042227480912,0.09210264520392465,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02100925562245473,0.05423874891021716,0.6987383421240132,-0.12769058500284552,0.08567207375793608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07102697659402897,0.047376787984379505,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04499022784884291,0.06502418661164285,0.48946692177009055,-0.1728852624686762,0.08290480677099038,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08707302949409704,0.040498243983099556,0.9415307631280134,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01455583096388334,0.07373041199625117,0.843615764028025,-0.15957500130913266,0.130463339381366,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09415644159478305,0.07394887448991709,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03891320103385302,0.05199763267645974,0.45475145077725887,-0.14118651467057355,0.0633601126028675,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.04911060627253675,0.006096712920715952,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01232929165700728,0.049817986141875305,0.8046791890793279,-0.08565691000606249,0.11031549332007703,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07224864915114863,0.05633159759889097,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035669159698279614,0.059066883120793195,0.5463231216695624,-0.15184686918256637,0.08050854978600716,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10580700712797732,0.07642015326868073,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06444942443562518,0.051599018408143155,0.21249839283344812,-0.1659387100313524,0.03703986116010205,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.06791813783878956,-0.12033767285406587,0.8284932427858109,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11187881572535006,0.05293150642009335,0.03526441727290458,-0.21598895072034327,-0.007768680730356858,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.22364543666236086,0.1007098106841332,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06807088253684547,0.13328023879432507,0.6098642276013377,-0.330217656575657,0.19407589150196608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07748014025251145,0.054223029965090215,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06128397785346996,0.05978096296210555,0.3060165013054003,-0.056298243871337715,0.17886619957827762,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12916749386890666,0.22811122037953122,0.8944539216937829,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007178118442607063,0.07574163724507,0.9245518193071359,-0.1561531356231617,0.14179689873794754,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13302459012615875,0.12742157583744443,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06568943091848704,0.08367328374389356,0.432952541738708,-0.2302650769791526,0.0988862151421785,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.18932965837292742,0.09987251364284873,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07489202361138689,0.08719590903675095,0.3909972106613748,-0.24639626512644028,0.0966122179036665,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09256100313201708,0.023501716750379906,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06424548484858486,0.09589309285521869,0.5033264566378834,-0.12436510867977951,0.25285607837694923,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.17230651759715326,0.27230503146242296,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045169506945882384,0.08062210284803911,0.5756653628425613,-0.20374383401062823,0.11340482011886348,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10785931698143393,0.06276351553437386,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040089315817471445,0.07132695724616038,0.5744479866153813,-0.10020253774785487,0.18038116938279775,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0998522022714378,0.14704333466551803,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10184406180102133,0.05008760154285889,0.04278758303339417,-0.20036056569222632,-0.0033275579098163283,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10721592510925763,-0.005791165187667456,0.49583625418844224,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061190464192900834,0.05535505319160683,0.2697510829179135,-0.17006743464401033,0.047686506258208666,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0024192617295030086,-0.044113401705591714,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08410892872775003,0.07608152730697174,0.2697110084868898,-0.23375247024515616,0.06553461278965611,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10848881982574918,0.013693775890223197,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014723616058372423,0.07657592170306939,0.8476404513139653,-0.1358923419043544,0.16533957402109922,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1013763772328346,0.13734240706981302,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09112118195104908,0.07835517227598963,0.2456660440295102,-0.24523671946223036,0.0629943555601322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07994251796204904,-0.007415555015675074,0.8545561163480508,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0510307135833733,0.05964068067913966,0.3927947153254462,-0.16833701632523967,0.06627558915849306,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11009385959508809,0.06842309445132934,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07331404152257825,0.07728607776225668,0.3434869298184061,-0.22532679410140227,0.07869871105624576,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07606314880617362,-0.004436837280900048,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057048214509592306,0.08260888551072565,0.4902939095962072,-0.21953031267717393,0.10543388365798934,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.18838580907968877,0.14141471485843515,0.9418332435783486,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07544170359442559,0.05905801885567489,0.2023166002049426,-0.19160197809715762,0.04071857090830645,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11273326174228938,0.036753940442228475,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08309393998840531,0.0636176306484823,0.19237545463478012,-0.20822244213813554,0.04203456216132492,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12716262990934815,0.04612696462882468,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007331601655038524,0.05465619003943277,0.8933700197851389,-0.11483398932857856,0.1001707860185015,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12359971489655572,0.10009322466400354,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027958300930224528,0.05511709909124665,0.6123025011682519,-0.13636724325996347,0.08045064139951441,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1428453088020242,0.09575230954470704,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042425636724492594,0.060808480978120874,0.48584065102508167,-0.1620288672320115,0.07717759378302629,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09627328048846368,0.048293505925931325,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041991950267701444,0.12637796698958415,0.7398857127523091,-0.2905627560795644,0.2065788555441615,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11979295467510176,0.13679104443063342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08275428755081246,0.0651701645401472,0.20500754612447245,-0.21093644382787308,0.045427868726248155,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10526810194229755,0.021219039530191677,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016267350773100098,0.09059380170089949,0.8576008895441535,-0.19445485312632818,0.16192015158012799,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13994790878589475,0.1261370200125736,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034308254881885686,0.07912764451620986,0.6648643957827265,-0.18994315571084106,0.12132664594706968,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08823283416893093,0.03794193160821893,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007468333923775199,0.0617216879234965,0.9037615557933891,-0.1288677365939917,0.1139310687464413,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12531300259831263,0.10551567288172621,0.9884347244265531,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047740351312947064,0.05980179879629863,0.42524160316285475,-0.1653635547074121,0.06988285208151798,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08014932452610089,0.03087280688762283,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003123368324004767,0.05775943014302117,0.9569064262208418,-0.11048273277008928,0.11672946941809882,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.058588882842943474,0.06398007272505958,0.995747388821315,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013927004262367117,0.07862098650874552,0.8595018486563246,-0.14071135901984305,0.1685653675445773,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1163898024643759,0.14577426757206965,0.9839789607467108,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07651004986342358,0.055657500650953255,0.1701321533723783,-0.18598189939414106,0.0329617996672939,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05785221184616868,-0.061961151249396655,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027065263534082045,0.05132827395573822,0.5983270004043082,-0.1280220261884572,0.07389149912029312,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09556479079354421,0.06224852869858403,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009405378921465188,0.05000606693192693,0.8509211097750236,-0.10776151368802218,0.08895075584509181,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06333195212675503,0.031235560934471603,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028786090266016973,0.06630581990554082,0.6644580507853733,-0.1592019489520088,0.10162976841997484,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08379320755053672,0.072465882532681,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017013877679334582,0.04736345964490462,0.7196512909290596,-0.07614455500016815,0.11017231035883732,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10539016222853294,0.1339244295494195,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013995893683431092,0.0870430847570529,0.8723510492656181,-0.15720776019552515,0.18519954756238735,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.047004646684249245,0.04144128559670435,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025617559214503146,0.06489387432169226,0.6932640535082135,-0.10202116624249263,0.15325628467149893,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11418571437053252,0.1812110488627593,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023976261789214106,0.06405711019535779,0.9701642554740019,-0.12359528127583856,0.1283905336336814,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13147433777383122,0.14186535859035368,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08492722838184923,0.07153838300428672,0.23598518120784184,-0.2256349318956969,0.05578047513199842,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05590824789669556,-0.024072788886954733,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00405634499201013,0.08910398666804978,0.9637162831557748,-0.17120086395606607,0.17931355394008633,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09950064676826982,0.12154023449229505,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028437562850215183,0.06692313812688527,0.6711543088265611,-0.1600676148910865,0.10319248919065616,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10482048640881385,0.05487084117829107,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02751015423409673,0.072264255936964,0.7036695513641504,-0.1696455656316096,0.11462525716341615,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09869673842182662,0.10321381499046184,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03635521244256363,0.056211296873977835,0.5182186463658318,-0.1469163149237114,0.07420589003858413,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1212418000407559,0.06938989093466207,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009250962598993905,0.09063212345359224,0.9187593427411184,-0.16901191419784858,0.1875138393958364,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1304790328761559,0.16745827880689912,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013324158616405835,0.08673802076499555,0.8780043136063924,-0.15727946976652285,0.18392778699933454,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1406559755017926,0.19246771438781987,0.986092730312823,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06115509172075864,0.06782920476320475,0.3678980030519593,-0.1945672717644308,0.07225708832291353,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08405785635941847,0.06167228177271614,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002230867041828632,0.07372662936270621,0.9758783346343739,-0.14278086330188597,0.1472425973855432,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12822460351646456,0.1286289421010819,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0185943159872811,0.0756293692944868,0.8059364229832822,-0.13015988315348329,0.16734851512804547,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1066165165476937,0.14444175112057597,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014914376342176894,0.07205558975996436,0.8361445787887921,-0.1268106128828796,0.1566393655672334,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1141001875507588,0.14963332452076897,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008978780416011177,0.08115976725004147,0.9119735360204977,-0.16861063100994228,0.1506530701779199,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12096025149804301,0.08101428567063529,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022020969145548613,0.05233270809963656,0.6741727406751432,-0.08091139899197487,0.1249533372830721,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.04009276585281254,0.0627090182010158,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05611068183328866,0.042208401981916166,0.18460608438090467,-0.13912971388925335,0.026908350222676035,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08513992056122008,0.0037312143737481076,0.8047111541643488,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10356405671510743,0.11114180602372549,0.3520835336770324,-0.32216710074872557,0.11503898731851073,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.007971484087280548,-0.05030045418278867,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04689915565424451,0.04837583235036038,0.33298942567116174,-0.14204880804689404,0.048250496738405015,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10022811456930622,0.03826123044126545,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0876120664408823,0.09376130255298928,0.3507447565363703,-0.2720296756550525,0.09680554277328789,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.040342169949271464,0.01324014121590822,0.9088510667694087,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0776973850787649,0.050193657883630054,0.12255325418926594,-0.17642248949358108,0.021027719336051284,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09494121513113998,-0.017719739555766844,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07105372697984906,0.11248571211227779,0.5280227801486674,-0.2923000784453271,0.15019262448562903,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.019329557007907817,0.0018711778986211282,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032796858492329356,0.04431802671773476,0.4597839501364308,-0.11996527776375926,0.05437156077910055,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05006955865286005,-0.00752204598380013,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07272184520454505,0.0486721066917562,0.13606159602914916,-0.16845423486965133,0.023010544460561208,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06212569735262675,-0.04200642719685863,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009138176967264024,0.04531216491393125,0.8402926658454546,-0.09826195078666891,0.07998559685214085,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09313260869338942,0.07453662437155602,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0733307178949377,0.06447727630180326,0.25619984187060985,-0.2001500433570596,0.05348860756718421,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11815974621369346,0.032973694583778745,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054652015752781336,0.07916448720604691,0.4904331744440391,-0.21035938188023154,0.10105535037466887,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14060207052166265,0.09609979970601602,0.9418332435783486,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02361566564622427,0.0813437480329456,0.7717468542064507,-0.1363780538125869,0.18360938510503547,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14157589415023955,0.17292927036653039,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06726214044870193,0.040513249052771254,0.09777528510359929,-0.14694700326924431,0.01242272237184043,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0886156942392338,0.023132714930248686,0.6772213442508546,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015031968344447883,0.052342980543842024,0.7741457823216129,-0.11798454118849287,0.08792060449959711,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10552717598759248,0.10090459235212516,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10521771731315506,0.048423488622082976,0.030472541400301787,-0.20046110406588533,-0.009974330560424793,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15209395977641746,0.028729076737496237,0.4177738059336711,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004966004244117323,0.0681464905602748,0.9419499398870541,-0.12907024016875662,0.1390022486569913,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11904053002527816,0.13081575252073266,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06874229809480709,0.059274912882658494,0.2469671500570579,-0.185329177996782,0.04784458180716783,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09590939872138204,0.02455215295489874,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008529776666846369,0.08031223337647556,0.915479477925109,-0.16649462641463716,0.14943507308094442,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11888896335156215,0.10368106388955511,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06157811628239839,0.07669581658170717,0.42259410050892887,-0.21242989356795197,0.08927366100315517,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07148204862122154,0.02912052463835887,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02919466932481866,0.08818056239253386,0.7407869347501481,-0.20263560980665069,0.14424627115701338,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.16421303771785936,0.13968109966146758,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033479305231018275,0.0638731332533152,0.6005095629191128,-0.1591103513754274,0.09215174091339084,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1387099256405781,0.12221939036412223,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09871220675770484,0.09980573078775666,0.32333702431467726,-0.29501850537540003,0.09759409185999035,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10465288149949746,0.015595299965522641,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02445133363704164,0.08158561342374529,0.7645858325568997,-0.1849207742719502,0.13601810699786693,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1099615152483248,0.10408901421272264,0.968605544021173,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030099253599340754,0.0621184603221213,0.6283067722549349,-0.15227906156645685,0.09208055436777533,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13938527433893627,0.13414282513905385,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025258224132818675,0.05834435624426258,0.6653468596983647,-0.14001480703785968,0.08949835877222231,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13335214297401646,0.10456218849769655,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09032424623260825,0.08188899614440397,0.2707945725178423,-0.25139040549766967,0.07074191303245315,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.009986592713289512,-0.0322966273942242,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10566025884787962,0.07012829656583508,0.1328127743643363,-0.24359448585613358,0.03227396816037435,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15814252505183574,-0.037906408721947046,0.7413978923376241,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05537090078698474,0.060978379284459545,0.3644919623340951,-0.17530830156103555,0.06456649998706608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08720176165150492,0.0374322276774652,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041233655698428046,0.09721385025004654,0.6717185341677074,-0.2324420258625045,0.14997471446564842,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.18731137147015295,0.17879226771205403,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06959795194899686,0.0611145899591479,0.25557452613839254,-0.18980326332466585,0.05060735942667215,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.0514172636521923,-0.11664610485073097,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03636867261426243,0.0605559631819969,0.5485155372311541,-0.15547522989970342,0.08273788467117854,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06971624701153334,0.011803599701038598,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020077121873035394,0.049893386501115446,0.6876392573415153,-0.11821162729902587,0.07805738355295508,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0969216281695931,0.09707306489007739,0.9632925656593531,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02524329335178259,0.06886637884592814,0.7141765707406165,-0.16069547454162747,0.1102088878380623,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05750151726513253,0.01643589110681402,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014078788428670493,0.04840223769289106,0.77132556747461,-0.10928037706801665,0.08112280021067565,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10898594542768973,0.11845335636498659,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04756450370885902,0.05650529931483059,0.4005011317357122,-0.1587038748975533,0.06357486747983526,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11414784004867295,0.04727526375954636,0.9219399112464703,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052677816077024486,0.05278439585433872,0.3189901180950088,-0.15649860164866386,0.05114296949461487,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11456391197051141,0.04543179820864687,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0045518714215478165,0.0915111307034651,0.9603575098131847,-0.1845436535459572,0.17543991070286158,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13960977174020237,0.1696612011205307,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004668622469048117,0.06864796908344782,0.9458186453982234,-0.1396912169836984,0.13035397204560217,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09001074123178927,0.09280400732452009,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04761211609755296,0.042272245362272066,0.26081480175741206,-0.1307567206791631,0.035532488484057184,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06362056074867231,0.015987356767783723,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03502867095612203,0.10177137957736995,0.730913853678985,-0.23520117279908004,0.16514383088683598,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10855113983360086,0.10659704525987819,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02720344254785247,0.07889725123665964,0.7304585819139788,-0.1823851865131897,0.12797830141748473,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1208029385930482,0.09603216166827981,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07231638375981014,0.08929685152407733,0.418590546554537,-0.24795293551437025,0.10332016799474997,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09921729356158393,0.06114199953833691,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006179649622310284,0.0643297406133249,0.9235271933087024,-0.120349490249359,0.13270878949397957,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15986944171872855,0.161380473572794,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08642298464944315,0.09027720068212809,0.3390846814272589,-0.2639877695129734,0.09114180021408716,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.0038990680909883457,-0.05458266532732544,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08985280185479448,0.09518670145874061,0.3458506426686241,-0.27707400542204647,0.09736840171245749,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07489030648951082,-0.008803653780470365,0.9073781709238445,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05261563318035842,0.0712892551439437,0.46098215137583376,-0.1928333310826998,0.08760206472198295,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08976882321554067,0.07516770914415556,0.9369772953428787,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010548945264779307,0.08554727935439946,0.9019326158803473,-0.1788105233758452,0.15771263284628656,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11114222447263608,0.11504465024243349,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034384806098170954,0.0752487996315553,0.6479966664553325,-0.1823904688442153,0.11362085664787339,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.00870350033531084,-0.017512057396649395,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.157869520447595,0.09426540784770997,0.09489515623365875,-0.34327864631856564,0.027539605423375607,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.4027050635923872,0.17161029429903418,0.6729775750805861,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0070260635161012025,0.061124326487789794,0.9085541235461401,-0.12725052551452493,0.11319839848232252,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13234571549499194,0.11930501170750751,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007468055510707009,0.05696848316436616,0.8957799501545571,-0.1195184556189248,0.10458234459751078,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13433905358109544,0.11150017930448804,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08412104499345102,0.08170773916979476,0.30395127610561834,-0.24483069280868552,0.07658860282178348,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.054407826414197884,-0.015758321978841573,0.8913059585247131,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05030159395118709,0.053722345617576696,0.34976255523902156,-0.1559672179389906,0.05536403003661641,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1252547420307224,0.06507237463476756,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08848017509023158,0.07788761500418799,0.2567481957506104,-0.24167608166745025,0.06471573148698707,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.053562977571919586,-0.032441186165094504,0.8647791852375212,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06303946683721953,0.08664561914534369,0.4673808209218908,-0.23346135194952672,0.10738241827508765,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06280868848521126,0.012506126640140535,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04114242539917914,0.057869123187232314,0.47759299527651755,-0.15496427999082524,0.07267942919246698,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0866870824581372,0.05552168459912016,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028908753656806063,0.061595897674562576,0.6391316697940326,-0.15006074149447224,0.0922432341808601,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09476816541221864,0.039666416694847335,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035372114568025664,0.07777836532178117,0.6495537354092826,-0.18835313968894749,0.11760891055289616,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14753261356503633,0.10847588666301285,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08129703757442705,0.07505121351719382,0.2794690779865955,-0.22891407134633926,0.06631999619748516,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.04594405816148327,-0.01437728254285741,0.875118556630215,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03801090626957865,0.1122528197977661,0.735103565136471,-0.25879918555946674,0.18277737302030944,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15075775033675376,0.1357527861835832,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10985723541096735,0.08839952432646121,0.21481170162578533,-0.2837288486251985,0.06401437780326376,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09578953587176359,0.0014254896586881223,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03873340899590523,0.0861849125340397,0.6534101793127072,-0.20824913762902075,0.13078231963721026,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1076301378281214,0.07142416191907812,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0345821362477931,0.09632445430224194,0.7198024741162812,-0.2240411677201828,0.15487689522459658,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13865977380607178,0.13434093075668047,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006964036191198874,0.049356841127900564,0.8878769574990013,-0.09011514670546462,0.10404321908786236,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14897487910393836,0.16036106445716972,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13335053471467034,0.09591459386882983,0.16533515849698177,-0.3220034182434708,0.05530234881413007,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.03130144271242471,-0.030298128404972546,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03836134421495885,0.10869652086156939,0.7243634090232256,-0.2521547958989309,0.17543210746901322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12227894323805782,0.07481666625059476,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05332783761104411,0.049492480047604995,0.2820147554152556,-0.15067380653357523,0.04401813131148702,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09124781274035816,0.013459583485390158,0.8770089248428307,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055712858379055104,0.058052202951079684,0.33787888379693465,-0.16989480963558218,0.05846909287747198,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11244916600632081,0.03511239253554924,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12010473376414046,0.0432093057368055,0.0057417045871045675,-0.20509242743746975,-0.035117040090811194,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08686311092934619,-0.08744605034360997,0.14446869304005933,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05541568658898925,0.07991130497284203,0.48848579258324143,-0.212591956659974,0.1017605834819955,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11428895391809069,0.03545187438902286,0.9404802865694325,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09599617929117506,0.04766030077654777,0.044769205593499145,-0.18973846405382394,-0.0022538945285261736,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07366415690313197,-0.07208899427146447,0.5055162930315735,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034633179433292305,0.06275294140362304,0.5813770629157398,-0.15806093811094854,0.08879457924436393,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10668564612483625,0.05268888735362006,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09908563729320871,0.04044690264807667,0.014792632093482017,-0.1786400044294914,-0.01953127015692603,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09411753914451632,-0.05047148849965252,0.2647257396604304,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03773088940562369,0.06344474770667584,0.552431833866351,-0.16251935085696617,0.0870575720457188,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08247969588072189,0.026095760161694913,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08286455066937115,0.0349578679242708,0.018319097826943413,-0.15162262303270363,-0.014106478306038672,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07522133808317279,-0.026272678327680012,0.3074355149054478,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01976601919236342,0.059773434598805145,0.7410857621062636,-0.13733343349957608,0.09780139511484923,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09847551751069188,0.05903229934203671,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0964661818127284,0.03471178833379084,0.005751084278238693,-0.1647402441578866,-0.028192119467570192,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08001730799286241,-0.034111922723864846,0.14446869304005933,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01644285321769287,0.05516926556908708,0.7658497240156804,-0.12495440095992615,0.0920686945245404,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09257456411444359,0.06506560479960104,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12508587869059734,0.06600507610856211,0.0589180437908384,-0.2549102092032955,0.004738451822100809,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0984023195084509,-0.11797632286305286,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04451541505330768,0.05414626462323093,0.41157084200167127,-0.15101483856601666,0.061984008459401316,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07579900321440414,0.0072896561058186414,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053746659718664595,0.05211550654192107,0.303125240161572,-0.15625181757965798,0.04875849814232879,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06219691058331706,-0.0060149563851642175,0.8911882060750217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031097193700684183,0.0630211392322597,0.6220161148713337,-0.1550524664060562,0.09285807900468782,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09523790822396454,0.043865696214774604,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07147137751335031,0.04183182350666312,0.08843806990166134,-0.15374972337792558,0.010806968351224966,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07740045579230338,-0.009670278958384385,0.6595715709697217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06708272216754631,0.05031988826703917,0.18337283244640712,-0.16605610710838592,0.031890662773293305,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07212022863962354,-0.004849312323912393,0.8024330451816867,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07137353881374413,0.05186225397564913,0.16965071221689632,-0.17338057824498523,0.030633500617496978,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.055024437089398505,-0.024912016887741334,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023900316293977847,0.06577349370970499,0.9710344796133346,-0.12697880315990023,0.13175886641869577,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1904153954217912,0.18748751822895282,0.9972922369220661,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09853160386080746,0.06683718588904394,0.14134137601152813,-0.2299925978171844,0.032929390095569486,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.027334117896982157,-0.08624061000659784,0.7596261630193029,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0017090777636238868,0.07979295404708106,0.9829573806904046,-0.16016207068233038,0.1567439151550826,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06815524813388503,0.08431400702047848,0.9987610176465104,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0982824944296748,0.07099837251789623,0.16958174678232105,-0.042706202531964194,0.23927119139131378,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09076643006635005,0.1972677862079571,0.7842677313995,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02904011080109587,0.06133781434062487,0.6370048611104044,-0.09276463220452427,0.150844853806716,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07344979827303244,0.10304702404489734,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05811338886581981,0.10187129241142624,0.569742193166378,-0.2604095861661839,0.14418280843454434,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.005660154582884388,-0.03530163351407405,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02363476153372332,0.04196381721507346,0.5746421206626128,-0.059697062828846056,0.1069665858962927,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.023266993071708583,0.0553686784127437,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059820532645938625,0.0732590480959447,0.4162657034677605,-0.08565741798023632,0.20529848327211356,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11004857015263902,0.18130288628712463,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02490078116015904,0.061433624164970814,0.6861671954123618,-0.09709422116847942,0.1468957834887975,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.058181152141906466,0.09469375581551598,0.9631430579652833,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04326712594553325,0.06280108634299511,0.49256680392669827,-0.08144338525727515,0.16797763714834166,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.10218197895541827,0.14953459342427522,0.9421219642690486,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01369580399594147,0.04133256884582811,0.7411209295667136,-0.09577409420156059,0.06838248620967764,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.026922269760614403,0.013773186880434498,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02615755404356148,0.06965554538787644,0.7081235604352563,-0.1121645543669314,0.16447966245405438,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0036947077449781198,0.03261096818236477,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040245638821480904,0.047173309593169496,0.3957712779125089,-0.13392248260029413,0.053431204957332314,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.008054019369458461,-0.02502529575687939,0.9210297285457331,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026180369641801718,0.08404277408211787,0.756108332944732,-0.14071192361312407,0.19307266289672753,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0529087970095038,-0.006653672658433961,0.9654293488033827,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030153240493235152,0.04189050835666108,0.47344660421047735,-0.053033007005291295,0.1133394879917616,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.02174776554176011,0.05579638138966114,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018313836513107355,0.03687114641407156,0.6205738822037958,-0.09153262595918116,0.054904952932966454,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0024860349192142167,-0.013567117480463433,0.9580596405456464,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03164864183812782,0.17728484778932246,0.8587040305510122,-0.32040393055793187,0.3837012142341875,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0571372467899005,0.1215109490504378,0.9839047884462332,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058006240580517475,0.13308007245722042,0.6639376985351491,-0.3222768899193394,0.20626440875830446,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.3842045342661061,0.34833828650596044,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010901481339806344,0.03963972272422165,0.7839154831411157,-0.08961811464573105,0.06781515196611837,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0012579865796823982,-0.013744141050202045,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026585463496307464,0.05622576932137672,0.6374393477885464,-0.13823869822768708,0.08506777123507217,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03297777052999733,0.011035506759406918,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018092183610390236,0.039018738008480186,0.6439609061026819,-0.05939129712033406,0.09557566434111453,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.005369376187578787,0.029106793248363613,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0036432247256248146,0.04843414421330645,0.9402011031415705,-0.09982383618069601,0.09253738672944639,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.02778353049114478,0.02566594690284327,0.992787535469879,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09782868604933327,0.07582140282547926,0.20016217982591053,-0.052737593247749,0.24839496534641553,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04350381328842548,0.06169845313294628,0.8152321105480133,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02201047711476493,0.08834677699967755,0.8038039843851684,-0.19744966717233045,0.1534287129428006,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11863462920017263,0.10555353692398887,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019948366758716782,0.052013678750065934,0.7022084382347235,-0.08334049087396495,0.1232372243913985,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06258381156515846,0.07617817272570551,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02375473699921946,0.10428860705189974,0.8203182161383631,-0.18334176810004169,0.2308512420984806,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0235524880030365,0.06391371629711716,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018990014330902354,0.046470023183833864,0.6837353719966832,-0.07329024202024742,0.11127027068205211,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.049533721211876956,0.0617360397279684,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008257259616805072,0.04797050426685605,0.863707769001575,-0.10351717402501187,0.08700265479140173,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03878250726113966,0.04331312198013927,0.9854445582989166,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012985339300050986,0.04109443082254403,0.7527198348410913,-0.06862005598686588,0.09459073458696785,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06603239585491243,0.07205657404181201,0.9654221498691481,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03631936935708509,0.06165872899071673,0.5572635093914002,-0.15876138525710778,0.08612264654293761,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04318963279551083,0.023559051250584537,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06351147419257348,0.04158888574419548,0.1301236443401678,-0.019075810574871052,0.146098758960018,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.011043929848733607,0.06907228258293047,0.7333906673033306,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061795821811500944,0.04131803325538335,0.1381401318995086,-0.14384524721524228,0.020253603592240384,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01232207017460023,-0.038600916619565835,0.751698554752432,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018884273160627327,0.04561560098194549,0.6798367187023608,-0.07169927003179515,0.1094678163530498,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03900474957680788,-0.019191865449263837,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056511651714779176,0.06527627732730137,0.3888659436393538,-0.07311409823551704,0.1861374016650754,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.08570952346826358,0.14474472122636534,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06373978016851181,0.08821353611349764,0.47176194179051467,-0.11143481989553261,0.23891438023255623,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.035070424339093305,0.1126710335979175,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010964939654526999,0.058672584066617066,0.8521590390242593,-0.10554718423731903,0.12747706354637303,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0013632255623791981,0.0013689264152598746,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006623909022048918,0.062020242876813216,0.9151758203902755,-0.12978381985299323,0.1165360018088954,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.012615668514437682,0.010991470195262122,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06157020073467626,0.06859727413593436,0.3717376785996749,-0.07465039070364002,0.19779079217299253,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14978855005301417,0.20378120949816486,0.915561182973695,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16935006269396274,0.04234973166279903,0.00012754935878731523,0.08525188872091766,0.25344823666700783,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.004689453282535513,0.17143387593004558,0.00588655122124249,0.05625597630143159 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1081042124396514,0.053932715506286505,0.047932550278606725,0.0010045281346705431,0.21520389674463225,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0795280742012744,0.18224389444709896,0.5190840165233017,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08255284252838828,0.062205325688521676,0.18772377111607036,-0.04097460608585092,0.2060802911426275,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02098153520434877,0.06409981934451237,0.8085168201280608,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012634997812711645,0.034766900624950706,0.7171157255320142,-0.0816751721529197,0.05640517652749641,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.022473984500906773,0.016988040575757868,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0837179186462326,0.05576510391205963,0.13667601896950973,-0.027020525879518795,0.194456363171984,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.00677966201375684,0.09208924837506917,0.7473242853882033,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05909678278025206,0.04581390669067816,0.20027298046046832,-0.150074121808871,0.03188055624836689,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.00024644861432186684,-0.050976977330868256,0.8152650866129219,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047310481178934376,0.046090723623053956,0.30733523369478816,-0.044216561416238066,0.13883752377410682,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01911205073675161,0.06498375712514139,0.8959335604367346,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00012527731605061875,0.039832370290717276,0.997497303467585,-0.07922447050905167,0.07897391587695042,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02059189088662536,-0.015536435616097985,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024687376076205136,0.03533009960929777,0.48644376778521126,-0.04547119982895703,0.0948459519813673,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.025629067267318232,-8.223716440586282e-05,0.9400644974323602,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015939322712449955,0.04005405724640266,0.6915825486300051,-0.09547874226426782,0.06360009683936792,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.029689488288793465,0.012790791675262583,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019921071958819942,0.03835883925022997,0.6047612233794131,-0.0960941245381264,0.056251980620486516,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.011680609258843434,-0.006827358216545307,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024149492827584145,0.04467067368019449,0.5900676349279973,-0.0645576120145963,0.1128565976697646,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02018638711900012,0.004529069516897865,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05134908924866253,0.048391381587976116,0.2913830421953502,-0.14744478260476657,0.044746604107441516,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.014561390229088504,-0.06488924326657379,0.8798016694357893,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02888142062927721,0.057120874711573046,0.6143201892424083,-0.084549316009985,0.14231215726853944,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.010769895841614915,0.04051446432055825,0.9557595790374268,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03407773287112517,0.0929506060172709,0.7147338306209403,-0.21865921494476553,0.1505037492025152,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.4343866538725613,0.3431704727354897,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02709587167846937,0.08282376489621285,0.7442889584653434,-0.13737571092338202,0.19156745428032074,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.1001422834690824,-0.03545290589869282,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013023305849770787,0.08843405149352383,0.8832410662903126,-0.1625891940560208,0.18863580575556238,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05231921458346889,0.09231436510531635,0.9870713197539774,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0036342523672710917,0.0702329223132516,0.9588422988927867,-0.1358344121891932,0.14310291692373536,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.056481209496461675,0.0689881747497689,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0683244105192225,0.06038702880482119,0.2607783105936572,-0.18824108188278993,0.051592260844344914,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.005436078794885925,-0.057567766509401604,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09368335076576917,0.051895837462830594,0.07427633143995518,-0.009371497424915776,0.1967381989564541,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.016086476088893808,0.08196585434108761,0.624582117553352,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010013761402307528,0.060975195110203835,0.9869323668212372,-0.1200832769397026,0.12208602922016411,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04057815504843819,-0.01664071711462433,0.9990141708527136,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030261915915155774,0.09399707863969774,0.748216689302088,-0.2169214852210746,0.15639765339076303,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03737982782045326,0.0021242309582710367,0.9637098944799569,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004134676630222744,0.052063939764214126,0.9368728850279407,-0.10752334267599081,0.09925398941554534,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.023581771733803367,-0.012250805947982361,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019222061928814597,0.05789453981299165,0.7406223667952663,-0.09574502027254073,0.1341891441301699,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.030444597158381426,-0.018953591225182562,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002199731420076224,0.052591169206446436,0.9667262707129343,-0.10223590780865331,0.10663537064880575,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03608195648703227,0.04623431073690108,0.9962315319978402,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11208209929453114,0.05234495136218297,0.03487070981072443,0.00813539990766432,0.21602879868139796,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.006754490778198699,0.10291524367206766,0.4493241481738629,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08386910763849537,0.05031390526466745,0.09889534373544173,-0.01604433672290513,0.18378255199989585,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.012972757658492888,0.1007889679304345,0.6779844217208436,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043058224000438995,0.07569327806325273,0.5708282301803562,-0.19337007291222916,0.10725362491135118,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.1331909005192814,0.08411377771725417,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004004496956167846,0.055485518135647706,0.942620070654436,-0.11418773953985516,0.10617874562751946,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.13155798349886458,0.13379397331582385,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01964119051004848,0.054232694491943956,0.7180502988597492,-0.08805419260891657,0.12733657362901352,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11014592456223485,0.12938006427364845,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03739697061466114,0.03889768088035014,0.3388345864910116,-0.039846114651383005,0.11464005588070529,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07255199635814004,0.11275813948629813,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045454310347078024,0.07565959162696731,0.5494519565420646,-0.10479064397841772,0.19569926467257379,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.08014892520706635,0.14724465936209574,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008657687293805701,0.040922745014062234,0.8329118927785383,-0.08992214859074198,0.07260677400313058,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.10617376240866404,0.09430131960766049,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0487968472810718,0.06725973104483833,0.46996784545590364,-0.08476764866018024,0.18236134322232386,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.16294845926016618,0.22607949893027054,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04749895034108163,0.02892245554408174,0.10390799426010988,-0.10493321503585556,0.009935314353692305,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04368304503761867,-0.08852882677474122,0.6856372888086054,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03812246003596956,0.04377841578953914,0.3861029645258357,-0.1250577175400222,0.048812797468083105,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0247401929928894,-0.06423687787299048,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02534219455232957,0.038019481370037425,0.5067046843936571,-0.050156960532777975,0.10084134963743711,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04025584232004745,0.0591826759031974,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02416809789281461,0.09307009969946013,0.7956874768130898,-0.16065067495172,0.2089868707373492,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.014931124515966633,0.019363990247580135,0.9735235918682278,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057080057829450366,0.0575820561283948,0.3241200326476099,-0.05726649370407907,0.1714266093629798,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.12634859331644177,0.1796374434738445,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015444917263015653,0.06511553980692092,0.8130291774554362,-0.1138616398276756,0.1447514743537069,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.11264748627665297,-0.08204235361872741,0.9765207460495163,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019801693725899204,0.04108984477243508,0.6310005553749414,-0.061794594574390634,0.10139798202618905,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.004096155507659166,0.026160192790730178,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04454309326432988,0.029006860796090512,0.12803043006834594,-0.10214497006168316,0.013058783533023387,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.08008793347243581,-0.11770070221443077,0.7288842902994255,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019420169234462645,0.03996921086177407,0.6281963503921968,-0.059950762212819086,0.09879110068174438,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.008302758731469918,0.005779820873785247,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005900410799040302,0.028387204059202132,0.835797003033662,-0.062271772124009014,0.05047095052592841,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03227354481115196,-0.03976572799955124,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018337227848851213,0.03388401956566467,0.5896800905908014,-0.08562417537967748,0.04894971968197506,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.044195528621654295,-0.05850839648046351,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012799801516090758,0.026743324320155422,0.6333346612323585,-0.06590674347269418,0.04030714044051266,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.014816073605879297,-0.005012724588004561,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0036719754734673158,0.03831138734487706,0.9238494800691006,-0.07240684702609516,0.0797507979730298,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.013069473956518004,0.011835451157918078,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011256101849250637,0.0355197049632146,0.9747873889343042,-0.06940948437605483,0.07166070474590495,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.003852191938395018,-0.004794340797313643,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051514319461236954,0.04764167902485469,0.28236546776468446,-0.04309261318480084,0.14612125210727475,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.029538883089998715,0.08401415514597088,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00410582836966605,0.0364871708412435,0.910647305548986,-0.06835046168722131,0.07656211842655342,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.013047355434271034,-0.0093749817467879,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0886945518620498,0.04735386426437853,0.06420722241696113,-0.005340837710438931,0.18272994143453852,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.041767972995486555,0.04939856863912089,0.5879399282333936,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12300016332891187,0.06639964357664883,0.0671371297646814,-0.2548566960153371,0.008856369357513383,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06523878726921738,-0.0586887465408088,0.5974602422332298,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008206379536076672,0.04773609799730047,0.8638807156503707,-0.10300080954890596,0.08658805047675262,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.018491946470719407,-0.02075364277416642,0.9854445582989166,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07256823901092134,0.05922636741626082,0.22356793523669866,-0.04504358886140175,0.19018006688324443,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01786467927239245,0.09771344756900865,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01938999668373617,0.04985225294994735,0.6982027906265267,-0.11838669104096855,0.07960669767349621,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.003827294305167949,-0.0205026839587113,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03584144198439571,0.03410585032731135,0.29603291936456866,-0.10356890144417769,0.03188601747538627,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0033903856352080347,-0.030235684689089864,0.8833721946393759,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009890827007630207,0.06001332877186136,0.8694508362522855,-0.12906540416772488,0.10928375015246448,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.006181470916057502,-0.007881057745320445,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02851946176052062,0.05217340134412274,0.585943210421177,-0.07508657328923113,0.13212549681027239,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.028132171351179826,0.056872526719618524,0.952608653969109,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015496297063994257,0.0713065214950034,0.8284354357934546,-0.15709691682346144,0.12610432269547295,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.035475965315716396,-0.047833386593572946,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029350091328186216,0.06755166534826756,0.6649437356294922,-0.10479412828248538,0.16349431093885783,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05242752615487163,0.08667438113409015,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02271405141077782,0.05571384942211708,0.684437323913091,-0.08792261185585229,0.13335071467740792,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05104610244949686,0.08175785722553695,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009036041106567812,0.03965257389248204,0.8202395497356286,-0.06970611207260485,0.08777819428574049,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03149121008304818,-0.021098549009603326,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04971525862399726,0.051816630163349316,0.33982188010099235,-0.15261281681566286,0.053182299567668324,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.022218443994689415,-0.028785889284965355,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0034944472716358847,0.04810138591081866,0.9422426107612953,-0.09202537214261644,0.0990142666858882,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06390598017085965,0.0653113922423947,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0050981579393715,0.05620976428968416,0.9279269905353476,-0.10652329397103437,0.11671960984977738,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03154727199251544,-0.023515206376874112,0.9916764739841218,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011820803047457312,0.042724554689460924,0.7826438819444818,-0.09666330126690617,0.07302169517199156,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.06084603531300843,-0.06859069908678156,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02863021556673391,0.05773825707822493,0.6211614912668978,-0.08602652009637073,0.14328695122983853,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06105403975063935,0.0778199973933196,0.9582992440631078,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05616288235317651,0.10672268226630127,0.599966841819622,-0.15576721372309738,0.2680929784294504,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.08900439300170762,0.15472516582265333,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029467344736773184,0.05190147192330966,0.5715691555328104,-0.07359869237575395,0.13253338184930033,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0779770846474987,0.09916532688753568,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06122018665024922,0.11770460915375594,0.6042178530581317,-0.17251783976414534,0.29495821306464376,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11069761600202083,0.1807673386233952,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026383867475491943,0.05180718262438628,0.6117689223411458,-0.07649492977615975,0.12926266472714365,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09073965997186184,0.10412790765622945,0.9549530254352627,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10497560921733086,0.11811143922748946,0.3764120495866151,-0.12957030109561418,0.3395215195302759,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14386233419136643,0.2538862594599142,0.9168661227448366,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060729036095991624,0.041466721700601686,0.14642297093794876,-0.021615655092036536,0.1430737272840198,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0012933609529624725,0.0525315992398899,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034441202281358864,0.02890556743008067,0.23648627154746138,-0.022959525965990865,0.09184193052870859,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.029341599217219152,0.05269561818346178,0.845523093424569,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08194439356520372,0.038819073669323564,0.03746115829659675,0.004857406641436815,0.15903138048897064,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.001957884269548862,0.0779758999997062,0.46391056873382996,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007185219806611031,0.03174030752698627,0.9819879118614273,-0.062311438294322626,0.06374848225564483,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0010077174776533186,-0.0026990100135804193,0.9987474789101741,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028115180662939002,0.048329613888133685,0.5621505419937866,-0.06785785428274997,0.12408821560862797,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.02748826581455984,0.0691115696825946,0.9512976205783472,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06633188735685251,0.0965693352269911,0.4938653485623282,-0.2580994484607815,0.12543567374707643,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.048061853131465465,-0.019635806938260437,0.9421219642690486,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04165611296773013,0.04228313145262213,0.3270962446493241,-0.04230980618710985,0.12562203212257012,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.055899466394384215,0.09444203720991584,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04851341519680465,0.05717052154908264,0.3982973055334521,-0.16204274061606996,0.06501591022246064,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01803465164668736,-0.025440194108524845,0.9212557438608796,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03440199892440139,0.04029042732716198,0.3953818580938626,-0.04560680476264542,0.1144108026114482,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.10462547187629133,0.13885378540507842,0.920957044807631,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010472022175899505,0.04291006242787029,0.9805821804420254,-0.0841636776053674,0.08625808204054732,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.014173203353383462,-0.005998346902381626,0.9985296925363316,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05938610512496327,0.06055403588518209,0.32927889649294007,-0.06086220920179343,0.17963441945171998,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0635335210508417,0.11970838864915449,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02398277436554658,0.04396576310612401,0.5867242447616507,-0.06332451777969314,0.1112900665107863,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.008200625589392253,0.02254282716258367,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02973164426027629,0.0678562218668379,0.6622888944804751,-0.16448065275809573,0.10501736423754314,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.043675942292603416,0.028308065185049795,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03786183341470493,0.07810284621021288,0.6289801180496635,-0.19295860712451848,0.11723494029510864,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.010008120924392966,-0.03546865069773748,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10035492721589886,0.061829501887062724,0.1079549672097804,-0.22313606424332655,0.022426209811528805,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14175186430142772,0.04459044964056502,0.6967044957001925,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008504256793265205,0.09792182154029122,0.9309795178584144,-0.20295758767202343,0.18594907408549305,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02854140663517224,-0.02493560654771874,0.9918526261485133,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0055282222512822565,0.04302136974483679,0.8980312121776581,-0.07990369184365716,0.09096013634622167,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11144966946794489,0.12593274799691678,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008632758626763083,0.07023058823967354,0.9024355313893283,-0.13083127092215507,0.14809678817568123,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.01925736880227299,-0.00386311419014099,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004854434644866109,0.03755866667195334,0.8974394410428189,-0.06972963377670884,0.07943850306644105,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07458885546179371,0.07487365777407314,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07540979222571959,0.05823502799115921,0.19855289340284382,-0.04023343201760418,0.19105301646904335,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06588719621638686,0.13931597093157252,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09689283946783707,0.026125675513756965,0.000354146130386751,0.04501242563160824,0.1487732533040659,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.07121436305627088,0.017790717242766776,0.015033219160481441,0.14366789467055133 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022773656250537566,0.05796035585579599,0.6952793835647053,-0.09232412356803167,0.1378714360691068,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14103176753162378,0.14858969024994131,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032131991122524343,0.0918967456679174,0.7273895289162231,-0.21462071540235142,0.15035673315730272,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.016960239416040787,-0.037456456652527025,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031259496318208776,0.04279010362066293,0.46690206658098266,-0.05371316908774945,0.116232161724167,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05485222303687603,0.08119744728046946,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035921691762008226,0.032578063972824804,0.27303121573673456,-0.028771886783101566,0.10061527030711802,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.029011547431374664,0.005354455529726227,0.8700354117066056,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004349227828280715,0.05938741445111357,0.9417765241370823,-0.11358240753804798,0.12228086319460942,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04945720645514231,0.05751135010341119,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01771971828651801,0.0328813590910304,0.5912445242707682,-0.08301558082764271,0.047576144254606684,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.024876867807830137,-0.04393998727176149,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002405916558102475,0.05080844003532491,0.9623336701676385,-0.0984895758481267,0.10330140896433165,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05679074340519807,0.06391882487042333,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005588605376822299,0.03585895835019401,0.8764893417459494,-0.06562017917554427,0.07679738992918889,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03671654970645151,-0.03165503746556638,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01853453939487928,0.04213503652502089,0.6610415145198805,-0.06513729258403474,0.1022063713737933,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.01698357245683386,0.0012205828710561402,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018658282983304828,0.054448167512545574,0.7326127362164208,-0.12678155281752315,0.08946498685091349,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.008886634450367376,-0.011451439361377538,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04091840145431545,0.0446286205535057,0.36158513467375564,-0.1295419971212184,0.04770519421258747,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.020741290582390076,-0.015527282230625328,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038297368004069986,0.04913744409389211,0.4377272614885924,-0.05927985762989744,0.13587459363803742,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07520394110953528,0.11640453272138679,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04822073022177922,0.06523912234978138,0.4616845549304307,-0.17777269775030424,0.0813312373067458,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11226020455720942,0.06710109578442791,0.9370609591482926,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0224249874633154,0.033958015058120176,0.5106462753824915,-0.04500890045068243,0.08985887537731324,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05697579890745535,0.08446598816221086,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04379313758394368,0.06724745977630152,0.5165080494946159,-0.08974699004998365,0.17733326521787102,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04983630464238653,0.10926684774269625,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027362633532922297,0.03817254216849445,0.4752849095661441,-0.04844046996346643,0.10316573702931103,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.027798383849391463,0.0586061367512685,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01711608741522691,0.08431964779815186,0.8395859157628882,-0.18455819699779769,0.15032602216734386,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.2184148096757128,0.1935826094636106,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009080747854124403,0.07510063404095176,0.9040196981502808,-0.1582157231911681,0.1400542274829193,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.15923513896080108,0.14574310242069355,0.9884605236688444,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04239551562268065,0.05987420296617226,0.48066866333699587,-0.1612938165054156,0.0765027852600543,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.12240567108677332,0.08459850261477772,0.9390961972850291,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027344468333671483,0.07629531764636216,0.7208540481232608,-0.12416291187456541,0.1788518485419084,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0385171807179523,0.07076992739205133,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05753074440209214,0.04934588408579196,0.2466494755446654,-0.04046040174597223,0.1555218905501565,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11425247413733698,0.16499128276861677,0.8552269457897888,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17667907595007817,0.20576538233836666,0.3927449964239391,-0.5852883455271687,0.23193019362701237,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.19300970058575587,-0.2846892200356802,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03043732325475108,0.0439873841862429,0.49068909795634763,-0.11778755058011901,0.056912904070616846,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.009402450886899021,-0.0366331095874827,0.9419198731133068,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020752361096281067,0.0383300603915142,0.5895181852559961,-0.09686826456573494,0.055363542373172814,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.010184408762515706,-0.027396885665603107,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023203954331792467,0.05041530897272888,0.6464067218657266,-0.07691085769705781,0.12331876636064275,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.1690236591389038,0.1917573160366638,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01469074917770919,0.037056015836890485,0.6926834379368688,-0.0882766526590339,0.058895154303615506,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03662610918916207,0.017805131999953698,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042963526535083264,0.053092391103848745,0.4204530206535436,-0.06246744004689763,0.14839449311706415,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09199468552097746,0.1368332064920448,0.9279200175745067,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0417293703680963,0.05828533428268584,0.47581623279842933,-0.07401375220021406,0.15747249293640667,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.13183640912576758,0.17334531533176806,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045708691798115715,0.02802274583351821,0.10624532437646943,-0.009938927721036613,0.10135631131726805,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.05281663358603755,-0.011444780925075669,0.6896374207352632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0059102745659911525,0.026655297021346256,0.8250103606990649,-0.047021862620925066,0.058842411752907366,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0379833964336491,-0.03910381245354793,0.9805258636366487,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02078685943118465,0.03663704639969851,0.571828066263459,-0.09354077264397806,0.05196705378160876,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.023702953447338262,-0.034996148196860456,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11639104853203364,0.07480299417421025,0.12311239468882229,-0.03215287301761313,0.26493497008168043,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07868664594909355,0.1935559235838024,0.724437501141491,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010609030950169314,0.05322772330352571,0.9841407958953384,-0.1046388064146219,0.10676061260465575,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09262720932991662,0.10830586133485581,0.998871063691614,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0029229882899850326,0.051746234347679824,0.95507505406516,-0.1056807543431718,0.09983477776320172,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.12507703056096287,0.12736316538224882,0.9948722834429907,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0984406485112335,0.07533826811479961,0.19455407805354966,-0.24804751802327468,0.05116622100080766,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.18153925602783139,0.07601753454023423,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012601959330954557,0.06127153803654924,0.8374951536084251,-0.13427509073169316,0.10907117206978406,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09558008330761475,0.08894086528837337,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001178573194014168,0.03697859866232716,0.9746426173907954,-0.07225359512160115,0.07461074150962949,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0010615924551456814,0.003201580837106364,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22305711522613195,0.10806375286894626,0.041791069823777935,0.008463918713959795,0.4376503117383041,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0697278098343282,0.3034233376137317,0.49032550277088105,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05320241781179229,0.059441878833148144,0.3730803395827974,-0.06483737302319789,0.17124220864678247,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04794823156424477,0.016659875668978634,0.91574265170323,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010397529356140238,0.028157423058277856,0.7127702015234374,-0.06631259115257132,0.04551753244029085,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.054686851843780644,-0.06371288651038749,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031113410616587678,0.06300593348409451,0.6225995932723749,-0.15623070764385483,0.09400388641067947,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.10733966767459585,-0.12356937783905142,0.9584620018167673,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09756051816682705,0.04056986186787537,0.018164225096176354,0.01699681286184071,0.1781242234718134,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0723696140109526,0.15373438158209551,0.3061308255062588,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06795695645626573,0.0776714650099686,0.3838669454242132,-0.22219709259595952,0.08628317968342805,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.10964789717833559,-0.15490438188658742,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15545134214403103,0.05552872434585324,0.006224149298174135,0.04518230058972657,0.2657203836983355,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.049867966660988694,0.18850297961052137,0.15202245270432702,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002991630195628252,0.06437858338642453,0.9630358130063715,-0.13083473788940397,0.12485147749814746,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0757803433876628,-0.06814714557863173,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09056333637435221,0.03842129470405434,0.020514733714454333,0.01426625964152553,0.1668604131071789,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03654246856209591,0.11551492031120121,0.3296651866882387,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018030131555266234,0.043833331714845235,0.6817741455504879,-0.06901417809289576,0.10507444120342821,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.06760716842150837,-0.04824594595118032,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0791019353006582,0.041631597214434005,0.060525231470506834,-0.0035701659818793696,0.16177403658319578,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.027617636440315795,0.10307863815254886,0.5719634373962896,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03920949681413028,0.03862716313585546,0.31270329575220823,-0.03749639382408359,0.11591538745234414,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.09340945188532629,-0.05596128180872379,0.9003405011538009,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06934331886211126,0.030102718651512414,0.02347552719002601,0.009565285547196052,0.12912135217702647,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01689563535277439,0.0835282665738235,0.36184220356199315,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014010691777141199,0.03962211792951744,0.7244331476192115,-0.09269236544980111,0.0646709818955187,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.08851803608459832,-0.09551889919464798,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08258057909611924,0.04600862765711568,0.0759193250800009,-0.008783437180942502,0.17394459537318097,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11124429049892863,0.16501517477872485,0.6296189902384475,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01447615298804161,0.07137327942076853,0.8397163452774954,-0.15620934075761517,0.12725703478153194,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0033221871339524493,-0.01177391318616489,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06310447576345511,0.04094824113533011,0.12669340298853457,-0.01821061577735371,0.14441956730426392,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.006092139575788537,0.057986441043748504,0.7263564310373228,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03291228659342336,0.06982102832384071,0.6384728324925721,-0.10573843813155065,0.17156301131839735,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.09738021698120901,-0.055454014427499226,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1014172572528701,0.056978548166381995,0.07835527690908231,-0.011730847074722162,0.21456536158046235,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03246446855284957,0.1340673832804295,0.6337247675321748,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0031322655860481145,0.04903135602033698,0.949200572775945,-0.1004988213310693,0.09423429015897308,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.013144786222081822,0.005298554709800327,0.9937952805575481,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04908662489377236,0.03137520219177082,0.12109582670970986,-0.01321830854411319,0.1113915583316579,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.053714666313890776,-0.009850613209771687,0.7228579124835106,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004607832200117678,0.066140559641032,0.9944563236831634,-0.13088126011699772,0.13180282655702127,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.045541450038599544,-0.030291868818726055,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0869985922423469,0.06394580906137737,0.17695851671803134,-0.03998511141154787,0.21398229589624168,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07438301818240421,0.15152695353021722,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0596385603924845,0.0888779277930936,0.5025565645888841,-0.11503191869708906,0.23430903948205806,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10895893584773139,0.18651353741275725,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13275904760086468,0.07681062231187538,0.08460810023592068,-0.018195734216473275,0.28371382941820267,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06628000518544512,0.2078386215643642,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06434542502100918,0.043524552004712364,0.14001285081743425,-0.021192734335277352,0.1498835843772957,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.03893872683277191,0.11366783557364771,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13529320150695157,0.06557128041727434,0.0396610150327126,0.006426932351066922,0.2641594706628362,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.13382703614173666,0.2968992252279642,0.4806551714956834,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0906729378008906,0.07618318111103987,0.23460098023117154,-0.05904874308945891,0.24039461869124013,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12446975699168963,0.205960683266567,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01930129957325408,0.06388422754668997,0.7626939899386641,-0.10624942948767677,0.14485202863418492,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04357412698518663,0.06466694234885742,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07165442526988529,0.08054683343730801,0.37415946263326605,-0.0866430771020809,0.22995192764185146,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1011894504936063,0.1762452594831934,0.915842680969123,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09406915054953505,0.06737954211803311,0.16337478027889255,-0.038350868625433715,0.2264891697245038,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09903733530623467,0.17047445630774083,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06112264648801824,0.0518663400961122,0.2392383832519779,-0.040809505826570946,0.16305479880260743,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07981695970444941,0.14186967347712373,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12960720800913733,0.06524563720025271,0.04759355611890549,0.0013809206591050005,0.25783349535916966,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12014086373027016,0.26609228410943764,0.5170078888029929,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0789112387956366,0.04948313431842691,0.11148391534022634,-0.01833723439530771,0.17615971198658092,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09483770647697362,0.18092320910173992,0.7040249164444842,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1234867770972562,0.061825156626193825,0.04639231885905571,0.0019827097114237108,0.24499084448308867,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11776935874909363,0.25212026283695,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09619532162305125,0.06812870257557,0.15865610944513636,-0.03769701153675256,0.23008765478285506,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09601599222030986,0.19831382042381365,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08420741600781348,0.07041406049993539,0.23237378100522635,-0.05417629733436083,0.2225911293499878,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09205206891610596,0.16562981849559671,0.8434307606856365,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05712832433924998,0.07280438896613603,0.4330554425630634,-0.2002097149196323,0.08595306624113234,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.018340617822174665,-0.0538861116295024,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001593752903544239,0.0753352812014577,0.9831310800830362,-0.14964906862197497,0.14646156281488648,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.04273872551945524,-0.07304521061333255,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07160149612162967,0.04941564777900151,0.14804876763446992,-0.025514346769911475,0.16871733901317082,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04969013953246812,0.11241500367028531,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07608446961409848,0.058983130179897626,0.1977397843488893,-0.039834205163172653,0.19200314439136962,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11432772786960478,0.20666605473067323,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08444011146372282,0.048698908807167776,0.08362138791208998,-0.011267134910088808,0.18014735783753444,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07355429636216863,0.16027466021564948,0.6500804664849935,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06543192906623002,0.04903289611516734,0.1827359130175574,-0.030931697632221145,0.1617955557646812,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07761055615443999,0.1607330230447092,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06484808549752687,0.08269421449025698,0.43334320909469726,-0.09766963314882927,0.22736580414388302,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06801089978633004,0.14060326708510656,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09627656428784172,0.06931015817175049,0.16550350882054093,-0.03993766610935402,0.23249079468503747,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08981819242547975,0.2030445757239421,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014314483086318868,0.058597850643922145,0.8071234136733556,-0.10084700750807041,0.12947597368070815,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.002667999120498526,0.02693781279406065,0.9744404042188741,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0989767894436123,0.0610182232075489,0.10549005916577031,-0.02094142361001501,0.2188950024972396,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12053595128996134,0.22200182003651545,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07460931929092027,0.05455195874576202,0.17210122280090093,-0.032600839699052725,0.18181947828089326,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0772108310317472,0.15162630298127422,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054472695546489515,0.05741749155869476,0.34327944201610106,-0.058369052767292505,0.16731444386027153,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10453322493546614,0.15320952795324588,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06467569732546306,0.05063305046982526,0.20214474982117972,-0.034832689097765185,0.1641840837486913,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.02993087365274488,0.09853067650521294,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054949384727056266,0.06356719393808419,0.3878153941786495,-0.06997828286430945,0.179877052318422,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11852216581574161,0.17109229382502095,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0828471901553561,0.06127524952480996,0.17704305430780434,-0.03757615292424496,0.20327053323495717,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05651199657348436,0.13480501231163008,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06873972489483288,0.05205210041229788,0.18731228658711274,-0.03355749942615502,0.17103694921582077,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11725151524146255,0.1925595978592072,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09415346304516176,0.0592233342990021,0.1125860907539968,-0.022237281340448375,0.2105442074307719,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09390570924763904,0.17278280654424275,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06709888545992179,0.08215610243504767,0.4145210506407745,-0.09436128951028006,0.22855906043012364,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07634650717435107,0.14435821948229083,0.9266313996019341,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08505847870178385,0.05493258574579891,0.12222991834198603,-0.022899720910891833,0.1930166783144595,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09614529837307573,0.18676586455668562,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05411882963297253,0.0739190368241513,0.4644689043105429,-0.09115316192349178,0.19939082118943685,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04154884274214445,0.09708377729132692,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1291389577308281,0.06946929468730545,0.0636932071348118,-0.007388021310523046,0.2656659367721792,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07716301688270166,0.21688358544607572,0.5858594185818494,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07598522455627835,0.09041604415515218,0.4011360357387679,-0.10170809190729127,0.253678541019848,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12290815180540828,0.19215748255113613,0.922683406617749,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1352991857244273,0.07771176393677828,0.08236482966015407,-0.017426596421763696,0.2880249678706183,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08919684124151382,0.2174307527094923,0.643528579284767,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0457266997005603,0.07817450516025715,0.558889175182472,-0.10790850093913691,0.19936190034025753,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1463389390781826,0.17543334194216095,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052334674801109385,0.046669474096248595,0.26272400681302016,-0.03938415350266698,0.14405350310488574,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.046311606498219006,0.08894471722754099,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03783838336969315,0.055197322853798865,0.49337674287163924,-0.07064010017213523,0.14631686691152154,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.087626629116472,0.10955708373888448,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022190682584098016,0.050491320699748765,0.6605153016424645,-0.07703916441482966,0.12142052958302568,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05539156233468851,0.07658658538489228,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07536587875482663,0.05447707355752143,0.16721985023237504,-0.0316971094804777,0.18242886699013094,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07980482283401807,0.14906487498581478,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05993691788753193,0.06464521983225309,0.3543401416566454,-0.06710937807514107,0.18698321385020494,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06886087551318036,0.1229006324422792,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05627071872469751,0.060089716139253325,0.34954972718713817,-0.06182271309826472,0.17436415054765975,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09306673964536764,0.12034947327663771,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02682176739522497,0.05048381959402844,0.5954787293972066,-0.07239333779139445,0.1260368725818444,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06667473730024001,0.10125100787831393,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06975425776509162,0.058248047049913175,0.23173151278704215,-0.04471976899131258,0.1842282845214958,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06031213096898282,0.11721735026123753,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058954263782024036,0.06204659840592882,0.34254384242824376,-0.0629849998636358,0.1808935274276839,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07396318866104615,0.12549991136565125,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04082664997376286,0.04864985154782104,0.4018091789746008,-0.05478418489265107,0.1364374848401768,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.043059266136677044,0.08533896602637481,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03569868791227775,0.05516483826782299,0.5178815552527885,-0.07271595415241086,0.14411332997696635,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06249555207875507,0.0789753228057112,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034840504125209344,0.059334589745309876,0.5573745350069761,-0.08176888894619308,0.15144989719661178,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08286354787648571,0.11358207209290007,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024755216688806675,0.06531363360526402,0.7048524898713647,-0.10360470299193594,0.1531151363695493,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.09062828613906125,-0.07918614295402883,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03322193422354919,0.052907527210516156,0.5303740387557756,-0.0707564477524494,0.13720031619954776,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1552529686472957,0.1533210270819243,0.945915518526879,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1034881720451974,0.07932460310168285,0.19269480132804784,-0.052407299096040125,0.2593836431864349,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05379883178568676,0.17230581815320864,0.8136230494372573,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0961459325888345,0.05386843491346553,0.07496712206856626,-0.009720907106675308,0.2020127722843443,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10117381831115341,0.21255888221455296,0.6283938912146557,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05647684785404759,0.0678522334591435,0.40565553324524917,-0.07687214463368174,0.1898258403417769,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1050700787964969,0.16147740957242215,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08235088701601385,0.08481749369000838,0.3321138581334425,-0.08433968088853937,0.24904145492056706,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.14559990218512206,0.21156325717662616,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04588669397519633,0.05784878781422356,0.428071710652998,-0.06780267450090689,0.15957606245129957,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07025727797908798,0.10097115205384546,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06172951856021669,0.08147966744350688,0.44908583087945486,-0.09840126870958285,0.22186030583001623,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.14419204043093165,0.23520336223716629,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027249244850281813,0.05431197079844481,0.6161135468190426,-0.07948926937057363,0.13398775907113725,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09688416336906466,0.12389514108808965,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04126884783534019,0.0733620122507976,0.574032189196348,-0.10290843155232943,0.1854461272230098,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07981034000095817,0.12097738953094633,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025401255150320157,0.049079457539920227,0.6050257128501866,-0.07105387802865577,0.12185638832929609,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06954791478584212,0.06413355259442605,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03249911183379611,0.04172715037326177,0.43648130741555535,-0.04950664063725416,0.11450486430484638,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.035513453800443684,0.100281775917019,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09290151656433929,0.06862093479091541,0.17647268568875926,-0.0419581932998119,0.22776122642849048,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07364994052932168,0.14456157262404876,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08831369679910182,0.0725105204755344,0.22388804476167157,-0.05419015837606479,0.23081755197426845,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0910325168621969,0.20632050734473123,0.8356888710841501,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01574493567334294,0.07797233318995819,0.8400634897283186,-0.1689828107251528,0.1374929393784669,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06593768503702374,0.059511464695420915,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08350169278024226,0.05976274921471691,0.16304066003825068,-0.033949155774035136,0.20095254133451967,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08641275321107696,0.16330969493431788,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045258459722101615,0.07857510839954363,0.5649119619138715,-0.10916404054831945,0.19968095999252267,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07121417120616484,0.12800877824360726,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08437855934403636,0.061936550515941435,0.17377706008060428,-0.03734442880843644,0.20610154749650916,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12295475367863136,0.17659143242615588,0.7883592203510926,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1200372227511417,0.08635578499263169,0.16521125120170668,-0.04967652633551617,0.2897509718377996,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08035114386486487,0.1849745094241193,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01640923549626054,0.07055091407580133,0.8161884671884942,-0.1222434341577359,0.15506190515025697,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07932511073449074,0.07503475235806957,0.977947781515814,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05054332538075898,0.06457666871396217,0.43422532120130997,-0.07636824808138637,0.17745489884290433,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09079604743891757,0.13141194867236355,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08956451017817135,0.07875416015845035,0.2560359244999838,-0.06520987787008897,0.24433889822643168,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1033345344552919,0.1711755035758255,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030916461538584065,0.06534745806088813,0.6363664568726419,-0.09750993284533302,0.15934285592250116,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07252413763401064,0.08519096067183246,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11907595036785162,0.06203674691288834,0.055564675214566074,-0.0028439522840063014,0.24099585301970955,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10989413206633167,0.262418022331961,0.5506521745982841,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018039733305575095,0.06366069685806205,0.777021987693881,-0.1070716941937267,0.1431511608048769,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0658267274185911,0.05966545122300578,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052562945646756454,0.05246373250830548,0.3169382414107979,-0.0505432531542134,0.1556691444477263,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11347123326491632,0.16773157440392691,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05079007659183311,0.06486638153805975,0.434044456701562,-0.07669086520551155,0.17827101838917775,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07587697638470306,0.11792278756884636,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06169465725618403,0.0635762321324081,0.33236972713969704,-0.06325077296502536,0.1866400874773934,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0928576584628594,0.14431711273730188,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052284836683072926,0.060642945033421984,0.3890534688065058,-0.06689584771642995,0.17146552108257582,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06436946700811753,0.10733432740823665,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07071297733377767,0.060157081760548944,0.24043156823657896,-0.047512847149972795,0.18893880181752815,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04592867528703033,0.11520330542676602,0.8475547497769944,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05114502264352388,0.05704815092553563,0.37045566092218163,-0.06097086597772192,0.1632609112647697,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08799577052468582,0.13618675964029184,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048464235672060624,0.06750593235729385,0.47317821189092435,-0.08420417637380534,0.1811326477179266,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.040659301737466236,0.054528386263553566,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029462007122766854,0.06108174849227833,0.6298024367329531,-0.0905810512349029,0.1495050654804366,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06426919343766553,0.0807826063851231,0.96007126858481,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03715510185409495,0.05988272734871537,0.5352682727247824,-0.08053153795529105,0.15484174166348094,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04201811347699973,0.052904459107437914,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03553601807342381,0.053423083179939636,0.5062778052312524,-0.06945557843640514,0.14052761458325275,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0628047392658118,0.10410795250235923,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0584957570290575,0.06763368954246515,0.3875626265867227,-0.07442373432631887,0.19141524838443386,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07763866678818804,0.13377871269910774,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14889008750475186,0.10108045163491278,0.14145860148380354,-0.04976183150446534,0.34754200651396905,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05439723512253013,0.2146265853180443,0.7597417987675457,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05625512585668375,0.05816497934165327,0.3339845928157793,-0.05805564915928373,0.17056590087265122,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09581212408010274,0.1850710655436864,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1122362474515645,0.07011636536558968,0.11014674783046931,-0.02556241003894942,0.2500349049420784,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10718982052328556,0.22179108340296844,0.7000359361715495,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008958908757723892,0.04947545911911237,0.8563885601475992,-0.08827448047734221,0.10619229799278998,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.036323587935133975,0.03173265640837603,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09306145605780802,0.07826463516643081,0.2350467739036926,-0.06075087575213148,0.24687378786774752,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08439142234988999,0.18646831063789537,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056043399754492323,0.07070735484419219,0.42842518634155236,-0.08291672063156424,0.1950035201405489,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08531126660600853,0.12729265914064808,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09299823350975386,0.05691398751048106,0.10296004005559176,-0.018853985732988535,0.20485045275249625,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07388648315255852,0.17693072382869993,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06776447940447708,0.08506763382004746,0.4261089708528426,-0.09941768520398636,0.23494664401294052,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1062634161800795,0.16805039361457738,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09828743595738018,0.05850645645421294,0.09366735520643399,-0.016694438985531787,0.21326931090029216,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09592097695656811,0.20519902600296575,0.6704521782043941,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012943245683839734,0.06043067287076341,0.8305017249097697,-0.10582026336887435,0.13170675473655383,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06828373348516927,0.0580533829039965,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06564003600263317,0.04258616698975511,0.12394009285407884,-0.01805392914027526,0.1493340011455416,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.052097497716361484,0.11503220726090481,0.7255813269452924,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08847148623291905,0.07744019342041909,0.2538789132301119,-0.06372058238757532,0.2406635548534134,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1144863582374713,0.2062118996673602,0.8634493629908433,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07134668962272485,0.05638662050824886,0.20641853739058758,-0.03946910303781398,0.18216248228326368,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.080723243067799,0.16112166699559183,0.8202168117716766,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02927657077658807,0.05871087948031108,0.61826657078842,-0.08610705372093352,0.14466019527410967,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06169584620775727,0.06770756749927047,0.9572656024379023,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05261357116849887,0.0735716146820976,0.4748995184704663,-0.09197563678234269,0.19720277911934045,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09398349561340709,0.12290076572392296,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02398000880002344,0.04637311024537714,0.6053349975410713,-0.06715638000384627,0.11511639760389317,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.049880768059877956,0.0863772623725138,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036468122732290865,0.060826677802496405,0.5491155523013838,-0.08307364896521241,0.15600989442979415,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06627770453167253,0.0793325156561595,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011775938777100372,0.05847287653151477,0.8404840926152621,-0.12669181959378636,0.10313994203958562,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.00017116498369935945,-0.005294940432663009,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018784074030566592,0.05498547075976346,0.7327982770139565,-0.08927805971913524,0.12684620778026842,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08140742052237397,0.08668137325546203,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014555422222847204,0.05338463789126383,0.7852467302442628,-0.0903606183288436,0.11947146277453802,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.021609572392259094,0.04199808166253804,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011168331208617259,0.062028523415116395,0.8571937002018886,-0.11073540992450048,0.133072072341735,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06565055561233459,0.045957092581553886,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012972262883837333,0.05336080675470069,0.8080358081376261,-0.11784146845473939,0.09189694268706472,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.013663564615856634,0.014271946405986526,0.974516576191754,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0372695214088813,0.05217039940993981,0.4753647441044888,-0.06526019418532841,0.139799237003091,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.03519671220988522,0.05047471159189446,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013050574354779434,0.05953964389282554,0.8266010507486358,-0.10396180860483513,0.130062957314394,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04354829019667135,0.02621877841632092,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04837935654659003,0.056485458919739474,0.39218448136056605,-0.06263068178456918,0.15938939487774922,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06583326463517446,0.10147311308270544,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06808193154514057,0.06855636226838807,0.32120838002813995,-0.06665087489398781,0.20281473798426897,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08234301565105945,0.1303384088248091,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08039330165698125,0.0828899043303321,0.33263055626002924,-0.08250900334245073,0.24329560665641323,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09500822073282515,0.17892752351586683,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06720735105356666,0.06711310671374013,0.31717318233940517,-0.06468904655562234,0.19910374866275565,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10022688695567776,0.16550124757463597,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03206779752204755,0.04826858152175215,0.5068013886590139,-0.06279373299209814,0.12692932803619325,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05255292848178556,0.067314004117468,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06751019011466426,0.06290154618650505,0.28373012945113496,-0.05610928977970768,0.1911296700090362,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0807007392777174,0.14386104113132692,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07967960327583025,0.06731384880210199,0.23715975623622002,-0.05261130979538929,0.21197051634704978,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10510044583270782,0.15691575336767413,0.8457206401631242,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06541247924366063,0.057503979282347926,0.2559263233859541,-0.04759924211630935,0.17842420060363062,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10191574596835855,0.16460974822826507,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08625329474730674,0.06786719844860215,0.20442064748078706,-0.047125108213227476,0.21963169770784097,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07324624701408322,0.14789864998889762,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07211473358342617,0.06136714446064333,0.2405659327145593,-0.04848920925661583,0.19271867642346818,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10525215728851452,0.17184679223208968,0.847586495289912,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06517685681864639,0.058212281323849355,0.26346802597970415,-0.04922688008445364,0.17958059372174642,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04702460379483328,0.10990260575892705,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07420645816900602,0.06578374167088183,0.25990962002270374,-0.055077357951317144,0.2034902742893292,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.13064564302901943,0.21115154912951392,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08193075138668872,0.05914877054451067,0.16669315951914046,-0.03431345395325357,0.198174956726631,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10400674426215592,0.19895481465376658,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06572374587958983,0.047478775621804706,0.166964531973395,-0.02758559076193598,0.15903308252111564,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08524536766429924,0.15373723838739778,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046289146191887426,0.07169341370091346,0.5188346837087663,-0.09460886110479766,0.1871871534885725,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08515988355811585,0.142901331828649,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.078044414826232,0.05554307135703288,0.16068159490067263,-0.031113563143560327,0.18720239279602435,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09882341653638341,0.1806406775718836,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02729138090272515,0.06317805963516439,0.665967432339136,-0.09687152678920387,0.15145428859465415,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0932191928297913,0.09808419108743882,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027387668556184845,0.050011267906501795,0.5842193459293711,-0.07089873777679997,0.12567407488916968,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.012261504296026399,0.010997748434330478,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04301764622145384,0.09951245217645478,0.6657434362571766,-0.15255270660567768,0.23858799904858538,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0987115126425834,0.061910444887612374,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05916175624035555,0.05845740431921825,0.3120621314821462,-0.05572371726597211,0.1740472297466832,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06648115127785556,0.12230576554690378,0.8991467149565432,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07774417028556221,0.07186630702857431,0.27992960658168115,-0.06349362171497211,0.21898196228609654,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1478138985096304,0.23848637422513216,0.8758370884717323,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028275520530609357,0.04067871595737214,0.48735772495184426,-0.10822080032565659,0.05166975926443787,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.010281965265606707,-0.01327565436231267,0.940275458344982,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07024853582680829,0.04911688411607742,0.1533490737240681,-0.02628015124963562,0.1667772229032522,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04874991969467188,0.09475824577906206,0.7704335108997802,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04770576132401481,0.06569748024653364,0.46813118640373097,-0.08140852649280289,0.1768200491408325,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07645924816382833,0.13975043775794344,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032375216764912104,0.050023659122155395,0.5178359621455202,-0.06593554184122377,0.13068597537104798,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0481516211252066,0.06627294469977435,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030248452340423206,0.060335069860721485,0.6163778652405871,-0.08832716952836256,0.14882407420920898,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08118950675237899,0.12482002458993957,0.9561867293882707,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027513661398986814,0.0613389246159048,0.653972642077433,-0.09303482139689455,0.14806214419486818,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07534795959205619,0.0637812766603308,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03522302124278487,0.06977908517614731,0.6139627756332852,-0.10191278447181379,0.17235882695738353,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08709938436092884,0.11077085337726808,0.9556150025445134,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11908915987390842,0.07267362469809584,0.10198255464095203,-0.02373524162140489,0.2619135613692217,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.113487337104035,0.24658485274142777,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09929765974510275,0.07261985566196895,0.1721988921193657,-0.043421070257482555,0.24201638974768808,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07382182582274126,0.17616241120466486,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012831852685774562,0.04467105420106486,0.7740524345181362,-0.07495951050735593,0.10062321587890506,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.053074546735900216,0.05999780711538765,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1095026211860892,0.06665272676135867,0.10111038190433873,-0.021488998500813983,0.24049424087299237,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08502969744018833,0.21099808426962954,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05324980490277462,0.060889811366912766,0.38230075748446835,-0.0664160422566241,0.17291565206217335,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08860513834124699,0.13462044411503252,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06564809765198514,0.06001895699952096,0.2746364345933413,-0.052306272278514976,0.18360246758248525,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05817490580515955,0.11099777999232975,0.8709804306040525,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0947108455849034,0.09397934258775564,0.31410354484075265,-0.08998536867136585,0.27940705984117264,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11720976431986421,0.20839824356954126,0.9014294790115309,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017402073797502266,0.059146673017546565,0.7687271534124003,-0.09883800930367027,0.1336421568986748,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.007322268977099654,0.014850223980530129,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050207167037185224,0.06756830570442048,0.4578369283813609,-0.08258382642676229,0.18299816050113274,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0618731042080834,0.11632186556547675,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05224629297030548,0.061444729512347016,0.39561498365214165,-0.0685101266262021,0.17300271256681304,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07693412590729697,0.16205244611703334,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06294769340782258,0.055766485575418315,0.2595991066308491,-0.04664935722635109,0.17254474404199627,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10529757270910181,0.19521611413835765,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017092428079625386,0.05799852793156797,0.7683564302411602,-0.0968912224379805,0.13107607859723128,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.01581267444533854,0.060758123003055234,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0022399402322220503,0.1303628441108614,0.9862988079440341,-0.2584401127804954,0.25396023231605125,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.2514307185696037,0.18650688788082556,0.9990098172080826,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03023148232321841,0.06949359034387538,0.6637538876829884,-0.10634324461323157,0.16680620925966838,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11713134443729861,0.16091335219104622,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025270796483390954,0.06882365961676748,0.7136571683816431,-0.10998732548750248,0.16052891845428438,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11798840950990223,0.15109591322568225,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032281289785726884,0.06539285157971823,0.6217946689750413,-0.09623431581045064,0.16079689538190442,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.02773103011922657,0.048790203392983574,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03449464050691881,0.06671425038373065,0.6053766021162666,-0.09661789064655296,0.16560717166039057,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10318900724039894,0.13482477354989444,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05226222826909526,0.06165537246460228,0.39708608490296216,-0.06890816481105297,0.17343262134924348,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.031450203182821275,0.06906866984302176,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03703038203243396,0.06621934856046903,0.5762999109655255,-0.0931095258756731,0.167170289940541,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.03352203127147477,0.05639975802241563,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05483333868199224,0.06685313784591075,0.41253588498749993,-0.07655214595004181,0.1862188233140263,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06943925198293208,0.1257139590336073,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040836555572592005,0.07041639443811888,0.5622542437897347,-0.0975517446238306,0.1792248557690146,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07462044496193716,0.09105781581692468,0.9512976205783472,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08478948021269815,0.0643110834678909,0.18803582657321874,-0.04160014248706685,0.21117910291246317,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10607563803217841,0.1735526378322332,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06279033445644551,0.04914275799424705,0.2020138485888791,-0.03378920217070254,0.15936987108359357,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.02769969567899505,0.09241325664056513,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10829464995990269,0.07728130538827087,0.16181690124728015,-0.043585158357206374,0.26017445827701174,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11173549052128837,0.22903477153918,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09206876669629566,0.06363960338852706,0.14867586784742987,-0.03300120611880247,0.21713873951139379,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05896729090101385,0.13755267880392796,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08757077619677474,0.061068797993719684,0.1522801951329106,-0.03244683073730925,0.20758838313085873,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08638763167423713,0.18266258308908864,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11804190201481425,0.057284586880752435,0.03991714421570559,0.005461349302075882,0.2306224547275526,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10441053250743107,0.2232703903050361,0.4822865917568812,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05401822771075977,0.06288828545871626,0.3908255424004349,-0.06957519107110136,0.1776116464926209,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10352075220864244,0.14701069801885258,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0259597785853753,0.058779209833674906,0.6589567974942612,-0.08955813454662262,0.1414776917173732,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.002148618554249235,0.023853732986834755,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07108804202368402,0.08043344449933118,0.3772728180040884,-0.08698661874281655,0.22916270279018458,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10391374889571972,0.167467777740159,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05628617304897765,0.06150012327811603,0.36056933495613386,-0.06457911109743228,0.17715145719538758,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05141491538773658,0.07161386015880786,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018523256260503867,0.06147336023602844,0.7633093292974314,-0.10228943087448364,0.13933594339549138,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07987841105970656,0.07361368268734773,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03944794727539895,0.0765918064297564,0.6067787168012421,-0.11107679891992149,0.18997269347071938,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04772306679367373,0.029958188304012815,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01668510670471145,0.05359515510322915,0.7557044426970203,-0.08864466021508491,0.1220148736245078,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08921889741125397,0.0859140395217671,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008065230802632757,0.07755449645813431,0.9172204610644441,-0.16048193749531067,0.14435147589004518,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.030447274085708322,-0.044917199570581,0.9899246798000758,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045632407776926356,0.06393575840984886,0.47577109346487256,-0.08001959412844813,0.17128440968230085,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07529790404239925,0.09529959314249203,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049725084712092346,0.0756045389830253,0.5110696359555273,-0.09885939934849973,0.1983095687726844,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05425480627263469,0.055357668035809666,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04181399108133966,0.06932703756018573,0.5467206722028587,-0.09443341212870099,0.1780613942913803,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06741328253169812,0.08971320750154568,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024677608951288725,0.05481433647463165,0.6527819368437913,-0.08304819711487155,0.132403415017449,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.043558639608581896,0.044325354116400026,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04079832874566448,0.0725328496198371,0.574070511697113,-0.10174940956708038,0.18334606705840933,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07718198450330707,0.09939112136834262,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0251343631828986,0.049815135234576965,0.6141216323260411,-0.07276658650611517,0.12303531287191236,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04373983537287701,0.04257301257620012,0.9556748710849078,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03525858939027902,0.048566925603354405,0.46823131359861936,-0.06018927234198778,0.1307064511225458,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06837272209708402,0.09498595967147151,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003988195585357384,0.08849850302238904,0.9640755288122411,-0.17791299677578254,0.1699366056050678,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.061767657549030276,-0.015619909417965643,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03188481458603509,0.0710832318157191,0.6539692908455809,-0.10781401126183407,0.17158364043390426,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05943870664728394,0.0714357726468478,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04402354594346675,0.06145796993622322,0.47416811280167337,-0.07675889486257204,0.16480598674950556,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04159663199566561,0.07373950112453978,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0484352880460089,0.07266684547479167,0.5054105029037675,-0.09437579034184908,0.1912463664338669,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07180786364953444,0.0948653463829716,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006389327631839422,0.05555495750108161,0.9084895246627797,-0.10279201000133695,0.1155706652650158,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.038488360871973895,0.021073686555432222,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030639055812316192,0.07117553281299452,0.6670599914400757,-0.10924116782254994,0.17051927944718231,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0457610781428965,0.058742655158679095,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04551543645624595,0.07383301177939854,0.537901761260383,-0.09958749135004127,0.19061836426253317,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.034873605089030084,0.06211552409101248,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03919827799971455,0.06164828037723935,0.5252078496921397,-0.08195817710586352,0.16035473310529264,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.13491165699602548,0.17077907890291075,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12148636889685684,0.05435398930311252,0.025904308663204454,0.014665276329237711,0.22830746146447595,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.016013168970623257,0.10949872200682977,0.37799338633918556,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0772187326640555,0.06766919638525254,0.2547514257761107,-0.055960569690112746,0.21039803501822374,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.049364215385923435,0.15720510248541628,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006053040125290443,0.0805349805663038,0.9940082401912622,-0.15789506395200492,0.159105671977063,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04256075999826988,0.05741843053501414,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08741055253363095,0.05830145345520974,0.13487612143719696,-0.027332156293498097,0.20215326136076,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.057649951090653406,0.023223290001411198,0.7471365331252404,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014503886673832584,0.09095500706278785,0.8734145935780223,-0.1935118405628852,0.16450406721522,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.20733393677609172,0.23526618106827119,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016131620885967896,0.051167324683347275,0.7527796234574226,-0.08457045581465777,0.11683369758659357,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09454920367339144,0.06620821605264261,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08749776229424751,0.05106032457538431,0.08765703941299592,-0.01299372819445982,0.18798925278295484,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0860074865782966,-0.013040011600410783,0.6570553152600204,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03915783132856598,0.05222884618105636,0.45401544676867667,-0.06363341888158372,0.14194908153871566,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11870192473212554,0.1425235183052785,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08202629275526412,0.0534162835193605,0.12571448791605894,-0.02310194510587385,0.18715453061640208,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04786794394076957,-0.005139775383334766,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018929098759622825,0.056728956203520704,0.7388626346940925,-0.09271878852209425,0.1305769860413399,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06588171587989981,0.0655162301629403,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003197563862376406,0.07608577559364262,0.9665067725663816,-0.1529414806505691,0.14654635292581628,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.19649561356187956,0.20319538706674214,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1016081088740341,0.049677925221575076,0.04171459986264683,0.003837309502552594,0.1993789082455156,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.038850214523377835,0.16795149547112864,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03255822713314562,0.08184700995092611,0.6910719065732569,-0.1936407915392831,0.12852433727299184,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.21286260781061178,0.19002427174176695,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07781712389026643,0.0836969250179137,0.3532664661941538,-0.08690624624722981,0.24254049402776268,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06500184780928661,0.1546237277885549,0.9092831415853414,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03800633159162398,0.05774490197549281,0.5109415903401795,-0.07564103191219287,0.15165369509544083,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05022108709328045,0.06574930148349126,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06052150032704168,0.11296871802975592,0.5925468908395918,-0.28285449463945067,0.16181149398536734,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.06473209978992078,-0.11525710402788618,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22679328043225502,0.1373008438797697,0.09964695802925122,-0.04342761145543664,0.4970141723199467,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.31633883152078945,-0.12599350604492335,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01574039102956184,0.05053992861282688,0.7556840855240823,-0.11520769363155697,0.08372691157243331,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07567073766998697,0.037865403139406756,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020178082268061046,0.0574604866647634,0.7257173242071702,-0.09290952532486632,0.1332656898609884,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04615142599786361,0.08092671356503553,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0370885431710271,0.052071741009455524,0.4768714511818192,-0.06539350937951227,0.13957059572156646,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07498357651970432,0.10334629402052013,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0046706081666336215,0.05865237012868651,0.9365842683435295,-0.12010395380126974,0.11076273746800251,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.014926856498667432,0.039336866123486636,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14692747379152565,0.1166593410315737,0.20886751192409908,-0.082669011487084,0.3765239590701353,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04963830319036385,0.18964829969293706,0.8221680401162432,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07799387093677881,0.07418992720733318,0.2939994611992004,-0.06801883905503772,0.22400658092859535,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.037232790606117325,0.13965437730314176,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09335989816640292,0.06555726683662928,0.15548253745250284,-0.03566292947059113,0.22238272580339696,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.09055577108794405,-0.013683093434961022,0.7742913314290888,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10257541389571753,0.12538331299181532,0.4139679659812001,-0.349341491270673,0.14419066347923792,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.16762000034471533,0.09365670725596459,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005964397613894069,0.05513663763066073,0.9139310324606867,-0.10254965790999099,0.11447845313777913,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0372043815954479,0.042816856834138224,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06007584973268969,0.06441461881930137,0.35177215716506727,-0.06669813982267951,0.18684983928805887,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.014873475998663076,0.06248173511824557,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034692007809651426,0.06043111196573596,0.5663572900103326,-0.08424206798849593,0.15362608360779878,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04563560773244147,-0.008302163915653558,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07390251173351095,0.05815831061382643,0.20483882397253736,-0.040558478604693096,0.18836350207171498,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.023964970319314566,0.04403372805945471,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044370120248184826,0.06824210630639971,0.5160809959943877,-0.08993672237077058,0.17867696286714022,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.011981846608910308,0.054884403539725825,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01018961652628998,0.05609526541531089,0.855984243863295,-0.10021110806412552,0.12059034111670548,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08481851150204651,0.08654141716314705,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013295995646102204,0.06769968572685732,0.8444358195076718,-0.11994331258165505,0.14653530387385946,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10042841790607647,0.11440101259424831,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0250485047929886,0.07933809442413703,0.7524409442705842,-0.13109627939153934,0.18119328897751652,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09192752295989078,0.0945360914065177,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010268773765442902,0.07064564581929149,0.884529685897339,-0.12876845923210084,0.14930600676298666,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12601964488877027,0.135978055247967,0.9880940960671373,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05099685475306133,0.06784321726669323,0.45284276133623547,-0.08252493695850056,0.18451864646462324,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04096497311812287,0.09174362421405306,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15064360543398744,0.10451733854888934,0.15056034855506906,-0.05505628425598452,0.3563434951239594,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1241341028081861,0.2735366956387101,0.7680900043895489,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004044238668912755,0.07225850414595375,0.9554046220882428,-0.14625572757926655,0.13816725024144103,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0003284385507804202,-0.03738748302678513,0.9950146798919537,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010235885876732187,0.07331038800636856,0.8890530432230792,-0.13404580877228742,0.1545175805257518,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04628453869566819,0.049085335604089855,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03143493723146144,0.05669185969392165,0.579668127332699,-0.1430098151155192,0.08013994065259632,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.045682581965206415,-0.10728236412934357,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006475326887858065,0.050991361880578935,0.9898766820398989,-0.09970823277179566,0.10100329814936729,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.015620526674525155,-0.03330547565859212,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022231722818387502,0.03606001436090965,0.5380300376787558,-0.04873775534899111,0.09320120098576612,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05921641183187902,0.052251405891525354,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024081342962807447,0.06161955965369143,0.6962240532621486,-0.09719170894886188,0.14535439487447677,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.013221093746906165,-0.014434664632473122,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004025750409305979,0.04858273961656402,0.9340164196572545,-0.09158962134348009,0.09964112216209203,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09986811788753065,0.0984269087998112,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05942373828910711,0.05288079813729766,0.26204743610011033,-0.04465061429758526,0.16349809087579947,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05817172273519555,0.08426397843881189,0.8670831795592645,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002832286622931867,0.06301677138672511,0.9641817914116467,-0.1211906085525336,0.12685518179839733,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08218352024030823,0.06531969731236395,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015877023216516673,0.04034060694753362,0.6941816561404593,-0.06351706119420203,0.09527110762723537,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.01884709350597936,0.023258607646486483,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031078148647677377,0.04500495724526946,0.49039538349153233,-0.11965211034039222,0.057495813045037474,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05237951221964027,0.006351778081495045,0.9418332435783486,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010527378288728662,0.0551999708532998,0.9847971689718636,-0.10758596339582549,0.10969143905357123,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09623933736966046,0.07869826884852363,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02107890711331835,0.027000123724432223,0.43561118155050005,-0.07421767383701736,0.03205985961038065,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05104520721459685,0.022664875479934884,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01585370444027199,0.0492729382119272,0.747869417827015,-0.08112004264909967,0.11282745152964366,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03541090760998107,0.016662099170513617,0.9635753025013546,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,5.949588805353057e-05,0.03916790843359597,0.9987890508500723,-0.07702660825541283,0.07714560003151988,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05071320051454974,0.0371017021744656,0.9996705945842735,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004154826502200757,0.06190401599077777,0.9465341473852787,-0.12598771506846404,0.11767806206406253,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04634048898531282,-0.05054641723290725,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044824781476998955,0.05760509500789974,0.4371148683960884,-0.06854742884925843,0.15819699180325636,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.05228982971496168,-0.0525993689263389,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21576356570581273,0.06060347353947164,0.00043215058183657443,0.09649026622290197,0.3350368651887235,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03591244716109433,0.24322110074981618,0.017682532570199628,0.16898657564190503 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10964527274002023,0.09015715744269943,0.22490391143504798,-0.06779243853551037,0.2870829840155508,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.019330817121530553,0.1085357380500978,0.8381630276861085,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0830353882959845,0.034936367998888614,0.018107684359713935,0.014277351176831113,0.1517934254151379,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0846238605303426,0.14309312592872192,0.30582723073916857,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07325254326101688,0.09062046866933146,0.419548208146704,-0.2516020943282367,0.10509700780620296,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.2065534947316064,0.11799066467025135,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05982933847575303,0.04321709092356193,0.16729228193982448,-0.02522593521493592,0.144884612166442,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.028620328224568777,0.07194162940951204,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04806705097628432,0.09061530053380638,0.5962004960016164,-0.13027232871724603,0.22640643066981464,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.190494832475974,0.2732361321708096,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02512552196942687,0.05716471973454263,0.6606026512838861,-0.0873799886646127,0.13763103260346643,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10855855647354863,0.12252506833647797,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002746358049237217,0.08614963230927924,0.9745903065039798,-0.17229688534821905,0.1668041692497446,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12494951080520988,0.12503326194154674,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008013371825435016,0.054403677659674035,0.883000740879955,-0.09905814997847205,0.11508489362934209,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.02097465673600001,-0.043939776266197494,0.9870713197539774,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016529643303118922,0.056764300646142955,0.7711060264912531,-0.09518780514471176,0.1282470917509496,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06304794934559724,0.08594773264755935,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033911476037758875,0.05368627992737358,0.5281015689098574,-0.07174813998623769,0.13957109206175544,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06690170738390068,0.05798539956269923,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07168223913841903,0.09216145378946827,0.4373205177234748,-0.10970011465442472,0.2530645929312628,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10358125310996723,0.18383151639942721,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1141913748471777,0.050493188387974564,0.024459998510759078,0.014816061375691358,0.21356668831866404,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.015163943244322485,0.06812531164337327,0.3691320687802387,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02247834875296162,0.05769241866179115,0.6970976802670832,-0.09106572268478386,0.1360224201907071,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.010507557872841205,-0.0068989896802377215,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06135827276024269,0.05400012702211683,0.2567755781815114,-0.0449190236760618,0.16763556919654718,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05017749856329354,0.07549892875344032,0.8647791852375212,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08999317705025367,0.04636954981834189,0.0532436829398885,-0.0012664303511055325,0.18125278445161286,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.06051721233666787,0.0010829375388409963,0.5411630668077272,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03673694349572649,0.07060893351029494,0.6032561271612441,-0.10222803624684829,0.17570192323830125,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.022548422615489897,-0.02708949630565542,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0686821764358149,0.05137550980160361,0.18230340843635853,-0.032429628032997204,0.169793980904627,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04167082173895988,-0.009419321841843206,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020281563928293344,0.06263769643072586,0.7463267670096626,-0.1435584041647804,0.10299527630819372,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12075447282330411,0.09282670848271272,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006801799583098352,0.06270032306641031,0.9136883289036009,-0.13020189489123957,0.11659829572504285,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08969492469842869,0.06407729065244279,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05074363638449649,0.06880277182159732,0.4613944913633994,-0.08466664836406473,0.18615392113305773,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.029648351766565596,0.06066314379881602,0.936984237335683,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05111144223894466,0.07347047330443145,0.48718489061569725,-0.0934853152370634,0.19570819971495274,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.13853845413111388,0.24124813865828726,0.9402561783874069,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056988490643020556,0.04795494075609277,0.23564771950796984,-0.03739131428286989,0.15136829556891102,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.019673801192792873,-0.008512038839234286,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06849839834958768,0.07102372519531883,0.33561873803041364,-0.2082797268916855,0.07128293019251014,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1855674383974584,0.12806280616980947,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04095470132904692,0.05319806609246248,0.4420072002943366,-0.06374406424295162,0.14565346690104544,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08156932910383763,0.10115444802274698,0.9329043222378208,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03270860444799777,0.06502430885353536,0.6153272893922652,-0.16068252096790928,0.09526531207191372,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.13380902606343126,0.09585936830080433,0.9560640930990785,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007365436178160741,0.041357925219721876,0.8587752982669259,-0.07403082566334693,0.0887616980196684,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07503443723028018,0.07347714594368439,0.9839047884462332,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004368774698540267,0.046415020622294106,0.9250748637837967,-0.09571787289144608,0.08698032349436553,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05810711953888707,0.04072190554914063,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04083074836506611,0.07939412707070918,0.6074444677526372,-0.11542431330431699,0.19708581003444922,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09375898937457433,0.15313710708503214,0.9535088362706019,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0566482490727974,0.06440475445135757,0.37981512401554507,-0.18340282463020155,0.07010632648460677,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0822471310312079,-0.002615119997004703,0.9191989190351819,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04605707647144838,0.0414716978350129,0.26766555541968023,-0.035563100509308235,0.127677253452205,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.057170084550610845,0.08018170705706565,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04186686963320286,0.04529794192419897,0.35611387628296187,-0.13101745255425545,0.04728371328784973,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07657497011412812,0.007811917279319535,0.9109996615965683,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001714313633755355,0.05584811958724941,0.9755328830659122,-0.10820000487059432,0.11162863213810502,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04397124990232738,0.047444222977736386,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017849470941675872,0.06019575860574805,0.7670402240229786,-0.10062140744961222,0.13632034933296397,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03276630672740157,0.04165819882948334,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11015093362075586,0.11452368528202235,0.33693414671727095,-0.11524238155997595,0.33554424880148764,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.17571741682254724,0.2709150356821759,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061250182226076415,0.06918824779497564,0.37673771486658003,-0.1974191197140103,0.07491875526185746,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08068886698335995,0.05457284334057244,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02482764780316667,0.0623092771517887,0.6905826052242376,-0.09780283260070914,0.1474581282070425,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09583022248573482,0.11543814598937778,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01700515383153038,0.037870056167995166,0.6537350545222108,-0.05752665576545661,0.09153696342851737,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.022511679641732996,-0.024850115878972602,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058198917256836374,0.08146716130439062,0.47555789240102864,-0.10213606951504389,0.21853390402871664,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1375452452975898,0.20483383166803126,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032063334930030635,0.06500202318679434,0.6221936357255997,-0.09586672131507917,0.15999339117514044,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07791497814277212,0.08606563653186122,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07245797732206204,0.0496760333720796,0.1457435018186578,-0.025309098712813963,0.17022505335693805,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05152166580900528,0.14353988004899174,0.7646625175952992,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02494547313970361,0.06814821233510644,0.7145938904639435,-0.10917657736910308,0.1590675236485103,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03406535145021578,0.03276347936744131,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002585171324936019,0.05856541755825789,0.9964810250558775,-0.11552073198257518,0.11500369771758798,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1252193047489725,0.1525937331495071,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09365762014410799,0.047563694575272104,0.04988383386711927,4.782426507812798e-05,0.18726741602313784,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.12363081014134436,-0.035117280478017016,0.5251695931527756,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07818566836655676,0.04765903335857996,0.10196982696422167,-0.015611763147688112,0.17198309988080163,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.11256151299515543,-0.03257514668658961,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04990832181304967,0.0867405326599298,0.5654793983996759,-0.1208051525972359,0.22062179622333522,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11437074318346205,0.16123732958885847,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010586875392478571,0.05372465992684042,0.8439187547140166,-0.11632202684213983,0.09514827605718268,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07542317768371931,0.07800513268595492,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05073805752303397,0.06418832561572939,0.42990071938204333,-0.07559056585999843,0.1770666809060664,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.05029439632140837,-0.011983779889997888,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046865694945304334,0.055552524381358714,0.39956522338545264,-0.06246686456968724,0.1561982544602959,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05625046298926006,0.0617229764756695,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004895342877641791,0.057734228790213726,0.9324854565439258,-0.10873101480010801,0.11852170055539159,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.030157994985565397,0.016192294900672432,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0318467609961243,0.08432164433476426,0.7059403389188554,-0.13410611513863044,0.19779963713087903,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.015693685617535612,-0.02830420480421962,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06071576340575819,0.05997243922091708,0.3121847911029055,-0.05731560156638676,0.17874712837790313,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.11316090516465917,-0.050735247057903436,0.8991737560866705,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025076574758703868,0.08175794391548934,0.759276426493645,-0.135830699366234,0.18598384888364172,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.012951894820951408,0.00803110572712145,0.9672325614747834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09381079958952393,0.05504141882788839,0.089372571374767,-0.014515856432052526,0.2021374556111004,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.13859926227357514,-0.016785151174336148,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016452142143552482,0.07637793546957325,0.8296019159732969,-0.1338667725835961,0.16677105687070107,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.007935321441126086,-0.047790287401111256,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09383448297084815,0.059172951499093886,0.11387091408514084,-0.022623415450475734,0.21029238139217205,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.1146178568872687,-0.0031760362630177796,0.7095033877612622,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007182110502767851,0.042959552794143825,0.9866727196000109,-0.08526662563464162,0.08383020353408806,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06532355695100536,0.028257266361400517,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04885050873715352,0.05969359588007881,0.41381997373793755,-0.16633308395587026,0.06863206648156324,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.025030024688935705,-0.05674340673997845,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0030834401443473264,0.04904254948248532,0.949910700141094,-0.09960376068373236,0.0934368803950377,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.049422556456585096,0.023672891689221383,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0413181002382036,0.05581560667261583,0.45973457768215353,-0.06853222981172807,0.15116843028813526,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06276656995634697,0.07603926062078596,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12181358373019181,0.05582415084811842,0.02989675515261993,0.011946437944394928,0.2316807295159887,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03685108617358471,0.13798334129133769,0.4120146569470434,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00303471865556986,0.07685360479861672,0.9685290058753802,-0.1482203577637115,0.15428979507485124,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10473088961915869,0.11811646341078513,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04883220778530211,0.04316019509264848,0.25880450843732405,-0.03611108959308109,0.1337755051636853,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04847855572421686,-0.043454133179493586,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024669575657968092,0.053601579140842646,0.6456855282204351,-0.0808233413026198,0.13016249261855597,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07433910254251509,0.10498265869969428,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04463072424662428,0.05854488899555792,0.4464742910160441,-0.07059108847361448,0.15985253696686302,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03758265769480309,0.042947960948211475,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0717353493031269,0.06683726704635326,0.2840269867831216,-0.05980663836605839,0.2032773369723122,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08489699628354058,0.1682508798783813,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0446805083751228,0.05232115207374417,0.393821213984465,-0.05829240845806988,0.14765342520831548,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0643461783616228,0.08672991611712753,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047055292611344474,0.07066469856111834,0.5060019113192276,-0.09201943796264439,0.18613002318533334,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08078845468781973,0.11165936350882398,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13313209209103044,0.05587293777957119,0.01782069960992788,0.023168929064864827,0.24309525511719604,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04847756248895636,0.07023037635182822,0.303536876132493,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019227341276375305,0.08370495584795101,0.9816895403614525,-0.16666190968914982,0.16281644143387478,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1637144693990352,0.15966248088736376,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06052499538319461,0.07154535715116131,0.39826162253685826,-0.08028295359590729,0.2013329443622965,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.011613332604276818,0.07358791551451908,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08746272046917372,0.14013905194580034,0.533038453202645,-0.36326947106897367,0.18834403013062626,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.15978172707326718,0.10131276092684012,0.9463787165114282,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0629568358584482,0.07244339022603065,0.3855317944224199,-0.07961852613559724,0.20553219785249366,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0229777611811189,0.02574229461397107,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009578315488350865,0.07451282650538667,0.8978051953574349,-0.15622652147454255,0.13706989049784082,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11058837390401045,0.13855124703634378,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03443788256753079,0.0677313562169225,0.6115216995390137,-0.09886375614436703,0.1677395212794286,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0235262913163584,0.022140142726437637,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07056692412706693,0.05072265219688743,0.16521086290547726,-0.029259995564368646,0.1703938438185025,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.13589328074280266,-0.056551854510154084,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10730135956973848,0.08032990468747374,0.18266482144361648,-0.26539811903984367,0.0507953999003667,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.14614335923474434,-0.062238960443255595,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040399869158534545,0.04892103765061892,0.40957929514807345,-0.05588130474013065,0.13668104305719975,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.024496811001829846,0.054950029346311074,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04233174274441667,0.065645076739267,0.5195238878449597,-0.1715273884758728,0.08686390298703944,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.16002336380114335,0.1445595493922054,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059170577674544575,0.038219797727149334,0.12266183019844908,-0.016049555995145043,0.1343907113442342,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.051304916455638776,-0.012829452657697712,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03101670619973881,0.06959962342729914,0.6561829881066616,-0.1059618569767645,0.16799526937624212,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.015788693076688766,0.01781521603155844,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055741762925945695,0.06121432297154541,0.36325467439057024,-0.06473374532480487,0.17621727117669628,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.059489295313689836,0.11537359619650253,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05273976020132152,0.08043863402872788,0.512562469472124,-0.10557098877342053,0.21105050917606355,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03995895319046255,0.06429343188574553,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06419555468359124,0.05048774208826141,0.2045564637473611,-0.03516903996108829,0.1635601493282708,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.025785288190073977,0.08298515243696206,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010054701453502386,0.059353290841162205,0.8655955547639766,-0.12686752455321218,0.1067581216462074,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.028166691330453433,-0.01846137903746845,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015550029930714025,0.06174699701661153,0.8013454660561493,-0.13707389048197366,0.1059738306205456,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07757236068186368,0.03159532095809481,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07672888789741937,0.08388077600424208,0.361081639461065,-0.08835631816253918,0.2418140939573779,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12131869739450987,0.2068864260643671,0.9134053709502656,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015388475360518399,0.06273861605500163,0.8064119895190295,-0.10808698412775306,0.13886393484878987,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06695209824830489,0.07029055979333393,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04074481847393324,0.044354799173683,0.35905451552174317,-0.04654957137488297,0.12803920832274945,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.013808789571406337,0.03487695923108485,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06774787158960219,0.07667725275431289,0.377665778353637,-0.08316012752591748,0.21865587070512185,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09963472010313548,0.18259568492665607,0.9170727894069044,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061240181247076315,0.07246159159695131,0.39872233231151577,-0.08137100274590797,0.2038513652400606,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03761736794634261,0.08119943881230633,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09086521036647514,0.045615872855240165,0.047302850340571925,0.0010889096616348154,0.18064151107131549,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.03559066977102271,0.04578459213178385,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014854910069654897,0.09608354286640569,0.8772398761164495,-0.1742464815563508,0.2039563016956606,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11708498248797329,0.12315064478879048,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08391702830511784,0.09537146210240027,0.3796364078071479,-0.10378292183146694,0.27161697844170263,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.00969639969719528,0.10537540342336163,0.9190466011506984,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0047025184301177445,0.05835526749317978,0.9358275662014057,-0.11014610145280258,0.11955113831303808,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.043026925799663454,0.028941525326593425,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04977516453598915,0.08391914230440464,0.5535500749198413,-0.115385549988123,0.2149358790601013,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.029757150519666622,0.08612043091555353,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011061568417077226,0.07362993533007113,0.8806849891785358,-0.1559721620616984,0.13384902522754394,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1301814676222996,0.1297422490425837,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1155822907561095,0.04048649074907648,0.0046132939431071645,0.03590109339072173,0.19526348812149727,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.03150439995373773,0.07898134689612582,0.12288700443082104,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.30459993299478016,0.22852398284743547,0.18359968338302665,-0.14515662142840985,0.7543564874179702,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.02040603068324071,0.21906159835934835,0.802983078068576,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01620716829498196,0.07568834516192839,0.8305943854537288,-0.1651689048526207,0.1327545682626568,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10729655986729102,0.08286885737868123,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0036957755671325385,0.08214660259964439,0.9641459270300466,-0.15797641516941946,0.16536796630368455,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1077837604086253,0.08730625835293883,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06840194085981013,0.07175511954431824,0.34123947679980904,-0.07281884011188311,0.20962272183150338,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.05440021547640953,-0.024647535690491867,0.9043732915535342,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006667146637960407,0.06277023901376362,0.9154843810376608,-0.13020484306432584,0.11687054978840503,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07335110228759417,0.04807523072137677,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041562808470479766,0.042192300311297455,0.3253973153334305,-0.04147558152583999,0.12460119846679951,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.006249501778486664,0.016113764127729458,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05509844076961622,0.06765310333025437,0.41606242544667926,-0.07804918894837645,0.1882460704876089,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.03303053124033859,-0.0188064610388317,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03459281035209503,0.048987154000544736,0.48064923029633544,-0.13100410740616455,0.06181848670197449,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08658279869397201,0.07138266403409238,0.9390961972850291,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03196613245173258,0.07914217988340527,0.6865752634811064,-0.18772533851136083,0.12379307360789568,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10198422079979604,0.027000872898964697,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0016793964653891492,0.0649030424108974,0.9793742828818742,-0.12941464929351465,0.12605585636273636,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0879986373394563,0.06315289184771783,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.076874817079317,0.061820269379106174,0.21466985765715088,-0.044793250328831,0.198542884487465,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0393208903769657,0.026256617846315562,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09894451997640964,0.07111773634713553,0.1651967111226328,-0.04102183129805785,0.23891087125087712,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1012488518090003,0.19723909330127457,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04903694925309418,0.050121036530896584,0.3286981662191487,-0.049605934585072994,0.14767983309126137,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.00374820562551992,0.03783422852926334,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04153296372603525,0.06913741172558054,0.5484837892504457,-0.09453592362656198,0.17760185107863247,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07065025675411765,0.08236193270072659,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028943997440808486,0.1009519675146555,0.7745365697851954,-0.16973890886030052,0.22762690374191752,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04939004933647199,0.08811220095296872,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013622394387693472,0.058550070374611816,0.8161860785693287,-0.12885440454612407,0.10160961577073713,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06528174798648166,0.028387812898660342,0.977947781515814,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05214262475638763,0.09231644881141089,0.5726250747600192,-0.12954477372433992,0.23383002323711521,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.13152492360371573,-0.042201031084930014,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06879997221700378,0.08571877066474845,0.422842441750674,-0.09990257910036456,0.23750252353437212,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1653966119852091,0.21844277962493344,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042009359600776085,0.06483876427597465,0.5175537658763516,-0.16961810705240943,0.08559938785085724,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05982391434901547,-0.013423718899980182,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010543231451999762,0.05625079950453408,0.851451222284215,-0.12125006166508451,0.100163598761085,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03961137644395968,-0.004704828807662508,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0541021564192171,0.05404694457714082,0.31764236394347684,-0.16047159417903495,0.05226728134060076,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06114461446619999,-0.05317131608139788,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04532869528065177,0.06120115382098795,0.45949820107354145,-0.07512089485110927,0.1657782854124128,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.012552462206511118,0.024540383258455447,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0034320653832144187,0.07846974398794526,0.9651434899843554,-0.1578678547596385,0.15100372399320966,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.053141874770841355,-0.011813807203641878,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020377129839519816,0.058217553011947504,0.7265774524458609,-0.1349547147535872,0.09420045507454758,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.039379333919174565,-0.00939033726750547,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04490006979162122,0.0458657287464881,0.3284142756655386,-0.135168110240141,0.045367970656898564,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06523051270822479,-0.029396671617931486,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00031355564657030335,0.07219206731986229,0.9965374721034671,-0.14176717938133582,0.1423942906744764,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.061241373228635744,0.03802807183587522,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01260341512070361,0.03251717424776596,0.6985989789510679,-0.051393422616092505,0.07660025285749972,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.046033526131856864,0.031683816914432096,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007465454755553016,0.07150399321652023,0.916918495218694,-0.1481919956457106,0.13326108613460455,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08320520037049497,0.04374771521860859,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03171921464931186,0.03305674294077774,0.33807870582264754,-0.09677797399809743,0.03333954469947372,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.015255502174636143,-0.04321573915373449,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007561923575036484,0.043010040184798544,0.8605586631649376,-0.09220970206239194,0.07708585491231897,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03661226151037753,0.0035470063064485333,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10348823900811158,0.1140712985760642,0.36503378200242853,-0.3279912148747661,0.12101473685854294,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09746295049829858,-0.10532979823515347,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008333703156295839,0.06514015334089263,0.8982882040388027,-0.11986820614071297,0.13653561245330464,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0033089353628299525,-0.021246940647650106,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05368821077998036,0.05163718698280504,0.29932725793825476,-0.047938598835870955,0.15531502039583167,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05602753798563901,0.0820973889504646,0.8866736552767163,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005402656587691472,0.0827812117215696,0.9480080845923895,-0.1683238173821177,0.15751850420673474,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05560892124486473,0.025748831346575383,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010651807592057137,0.03630575676316966,0.7694304685327529,-0.060801314588256106,0.08210492977237038,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03704727054339717,0.013469397575571869,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027832193281451253,0.06858155090895274,0.685166476001775,-0.16280709460024,0.1071427080373375,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.033422266207223876,-0.015250665280371568,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01239614893541712,0.0435873702568615,0.7763064911207183,-0.09818016695763696,0.07338786908680273,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0823098582152902,0.06211283946452015,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05809307926080322,0.07287678542754147,0.4260145874194011,-0.08533524499176014,0.20152140351336656,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.006111798834572769,0.0069885650611334026,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02960836366206889,0.05073968316775416,0.5599823430047758,-0.07025207457162233,0.1294688018957601,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.02926032981923946,-0.013856325554887805,0.9506287080350535,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15031179117460425,0.15169566408978372,0.32559694404511297,-0.453547102947545,0.15292352059833653,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.061637892434934685,-0.012466688130476111,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15309288445158256,0.2332295990377845,0.5139930362568987,-0.6193122098572292,0.31312644095406417,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0613678576026273,0.033323197804528845,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16928553585423406,0.14118471703306879,0.23507665640951794,-0.45150976384375585,0.11293869213528773,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.021417452481400735,-0.04445365768025304,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10532325487495292,0.28067682782137526,0.7087571614958156,-0.6663882391811637,0.45574172943125796,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010724137636336211,0.16920496138859747,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12336716427046582,0.15769771561287316,0.4370150407631811,-0.43860040608182915,0.19186607754089754,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04787095545752627,0.026274526891370616,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13102709545156507,0.09389924160023655,0.16787303738205833,-0.31872900488147365,0.05667481397834351,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02059762312369495,-0.05082648747357175,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19052089530907074,0.16713360986177977,0.25869949176196416,-0.5246162209617375,0.14357443034359602,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04504000969550276,0.0014525034686254878,0.8664830381179188,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11465602669182319,0.11245917191184177,0.31191113925281744,-0.33945870817275503,0.11014665478910866,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05469510104989216,-0.00953810451814227,0.8990379896110621,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11036438566829417,0.14917657198000794,0.46219911960829774,-0.40856410406500965,0.18783533272842134,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0060699273214421855,-0.04963949784272701,0.9372011503139762,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16161444414851087,0.2475843666967121,0.5163208963000215,-0.6565285412379858,0.333299652940964,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.033483873835531246,0.0756606503802274,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11365235469922835,0.16303512264576026,0.4883437616302859,-0.4395549211441467,0.21225021174568998,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07234387683166953,0.10919552435147532,0.9404802865694325,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13855308730116356,0.26020939929964376,0.5963053516388116,-0.6587042649655166,0.3815980903631895,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.042389996451177796,0.0666374169130916,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10449834645600081,0.2035334741723986,0.6094817214660684,-0.5113559640894745,0.3023592711774728,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.025544987267754872,0.0666804706672754,0.9548186116040361,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08951617865643219,0.14730058853064693,0.5455988051937313,-0.38396585957144896,0.2049335022585846,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.011076282914904511,0.02756284846855426,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3042958934628656,0.19166322671732047,0.11745066417651907,-0.6874252245335001,0.07883343760776884,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12615043645881616,-0.19567541835940055,0.7176009922554474,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2504171511408201,0.15109109813540503,0.10249243292406324,-0.5524439527907897,0.05160965050914956,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08957631023381694,-0.35695131445890055,0.6839484127328216,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13282460965022552,0.12698163889578104,0.2996154382152517,-0.3866572889891096,0.12100806968865857,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06092570623347941,-0.08214404764147477,0.887112028553774,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09400026074775648,0.18774051634695818,0.6183604345452851,-0.4692882055184653,0.28128768402295234,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08071021021813818,0.12545904239370248,0.9572656024379023,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08898191642382007,0.17023486246193298,0.6030453270681294,-0.4292765576913188,0.2513127248436786,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02863920980282399,0.03633437329470858,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04747345631527538,0.1673365639174995,0.777585199139124,-0.3819744813445923,0.2870275687140415,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04204152251015651,0.12234313775832754,0.9700679690002965,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1812481097517472,0.2408166151597955,0.454514765706452,-0.6626336642845669,0.3001374447810725,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09337065748184634,-0.02978238869323162,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.125035753258967,0.1948114465988251,0.5233498077969507,-0.5144582862020874,0.2643867796841535,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017041775254068053,0.09552066213930865,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02080951079942935,0.09933194284957872,0.8347489620546439,-0.1777522136884659,0.2193712352873246,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09154969458246298,-0.047296263360098297,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03154470425237737,0.2479248357073829,0.8991662091731312,-0.5271393891966157,0.464049980691861,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03781340106584676,0.13315769381643522,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07094364418996205,0.17639693923334449,0.688933407844579,-0.42355610140928535,0.2816688130293613,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01956342550114624,0.0370709616753463,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1088261653484627,0.14920413948029373,0.46851727634672324,-0.40708099039304524,0.18942865969611986,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1273780414398217,0.12957018780694685,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09267625313125515,0.15160887386428465,0.5432456794583573,-0.3957380737154664,0.21038556745295606,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09555157390828475,-0.03284863364627266,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08679091901328212,0.12343698725768125,0.48461341457393015,-0.33353794068979903,0.1599561026632348,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.23179816367618422,0.18276341730736437,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09797438801436052,0.14874728942921195,0.5125506872827621,-0.3953159828192754,0.1993672067905543,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04480773721347267,0.017044566046403097,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022700247598425493,0.1226389894364684,0.8537562474388162,-0.26785209435968327,0.22245159916283228,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12289657585735073,0.13023482914420897,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14996241644917868,0.14302329572994546,0.29847049176126556,-0.4358619108855813,0.13593707798722393,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02999653754368315,0.014008612694845279,0.8856954470736713,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14360223471062727,0.16205282949152805,0.37896388819137883,-0.46754122511885854,0.180336755697604,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1243709378551329,-0.05112484923098977,0.9183506089424412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08303685333842664,0.23432800506876114,0.7242703070949439,-0.5514518611141334,0.3853781544372801,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05250012467754903,0.041604515821230426,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1356805034765614,0.1700254452637272,0.4279157879318988,-0.47555652572966983,0.204195518776547,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0012560495818535124,-0.024468614575686765,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008276591487155089,0.28961309000679497,0.9772928715107537,-0.5872049093707624,0.5706517263964522,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11059179449015968,0.05134325100913496,0.9982821339400993,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10431670484742403,0.11316197972577499,0.36018784187688235,-0.33052427913035687,0.12189086943550884,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2957103713776532,0.07100898877466215,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09538921321433078,0.23387889623512634,0.6847834684590697,-0.5629064652235534,0.37212803879489187,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0033710642749800223,-0.04920278891748399,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0402666290005238,0.15311683672143495,0.7934381367689669,-0.34634282438492275,0.26580956638387515,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.4590573672519115,0.14449396565581338,0.9732342286065081,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11761645751399027,0.10963146537618865,0.28750329640033073,-0.33676663417162245,0.10153371914364187,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05594972916763291,-0.0720765680377886,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05647377146493206,0.10200896899797168,0.5818329534109208,-0.2603867949738184,0.1474392520439543,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02253531125210583,0.03965077450042433,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11376407531321592,0.1070011973699523,0.2918131739124074,-0.32765642114421745,0.10012827051778558,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05622523002727782,-0.06160140204732063,0.8799526010712531,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07507268843789684,0.14224372600205482,0.5995393082615863,-0.3594138451927046,0.20926846831691093,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0032336619426973144,0.03325382304895656,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10931080726614456,0.1368295343902797,0.4274079863567657,-0.3828291492012528,0.1642075346689637,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004243484572203527,-0.05984819445238297,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035437799406607295,0.13285294159944175,0.790551046882513,-0.30100704561799024,0.23013144680477565,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.001993006238585174,0.08518258171816952,0.972929334907502,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03953143862357865,0.10871815728434159,0.7173832728096308,-0.2568559384193324,0.17779306117217514,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.048808967815108545,0.04218580926338283,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1982676548594025,0.14133407128989792,0.16565553827979979,-0.48079043775427344,0.08425512803546842,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02020916422587805,-0.10496219158361222,0.782722418372054,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022401346480963428,0.16188770574952951,0.8903918526825667,-0.34601025923215367,0.3012075662702268,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.040983944500535795,0.023495217475652048,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15113945082833147,0.10745468750308623,0.16455618313250242,-0.3659383105187234,0.06365940886206045,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.017790923781745648,-0.10620781431100026,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04420365831764849,0.09259289782660662,0.6347574619323066,-0.22929422375261696,0.14088690711731996,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.030723905428380764,-0.05370538418044792,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18190059190983526,0.14386983985218976,0.21083998745227836,-0.46949230393451624,0.10569112011484572,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00918507368282488,-0.033675636990404025,0.8252886794984905,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09784681836375458,0.04169304238160246,0.022142843722990344,-0.1811900225430434,-0.014503614184465774,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2597122309316758,-0.1858932466948276,0.34668618042031035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13298188066621972,0.10344993613137493,0.20340871405053257,-0.3397753564317604,0.07381159509932095,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.28466171327047474,0.10498726011794139,0.8179445630780711,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2167225535836207,0.22415474234665603,0.33737867985030323,-0.6648014989425418,0.23135639177530043,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1354192184161362,-0.08397593967807679,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12250022939817239,0.18376261031294772,0.5074867067763915,-0.4898364533094591,0.24483599451311427,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.25379839698871476,0.12786145607157479,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1925698686832699,0.17871509487946247,0.285420765584993,-0.5498162530112332,0.1646765156446934,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07660137379146677,-0.0247936873560994,0.8771632762317894,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019823794756336065,0.20267041972883024,0.9223963434728493,-0.3853086016267953,0.4249561911394674,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01951446816003333,0.20106332233010388,0.9911128933864998,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21382884072577255,0.17276068796471172,0.22048781943217147,-0.5591725352303225,0.1315148537787774,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07044068121734988,-0.12203181651077755,0.8354330838437122,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1054080174673301,0.2568768996621903,0.6829678761607648,-0.6188976232758896,0.40808158834122943,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12920783384746273,0.20269306809812065,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08793945134417251,0.1815019200713351,0.6297314424331069,-0.45075661985364024,0.2748777171652952,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06143043518030335,-0.0014245926264877362,0.96007126858481,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13837648968757424,0.16245496065278817,0.397612324822309,-0.463119328833276,0.18636634945812755,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.023225636805521196,0.010432345881706977,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.125221157744414,0.09388100146533943,0.187139320929639,-0.3128866056641964,0.0624442901753684,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02661057188721463,-0.08192586145652887,0.8085168201280608,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11246679316302925,0.15658163138107012,0.47529318516001573,-0.42546901438440826,0.20053542805834973,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1025907347625909,-0.057487547414140486,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09332683987113773,0.16410439337908064,0.5716113046250341,-0.42136684805596086,0.23471316831368544,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07355467601774329,-0.01704959507273397,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1593748278790156,0.18629144298330588,0.3955611190884326,-0.5317661162696917,0.21301646051166048,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.018091069742467717,0.03484339314041156,0.920957044807631,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2550494470722793,0.11544791260792435,0.0308630643167776,-0.48582653607647874,-0.024272358068079813,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0032656817740679494,-0.15303794097422843,0.42002168600416523,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01146473677276121,0.13965100882768866,0.9348351350625819,-0.2906231257442878,0.26769365219876534,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008978680207842822,0.05714245720585629,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15139251033853052,0.14192520921653934,0.2902406967480898,-0.4350969611113958,0.13231194043433475,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028228986020699252,-0.08615646516969111,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10667986223243496,0.11893543566563305,0.3732120885086997,-0.34442841049399125,0.13106868602912136,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.16724580620968368,0.08476630376909432,0.9157828620037275,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14953509072823207,0.10379947710140237,0.15472464870176691,-0.35702728893689384,0.057957107480429676,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.014213240825944653,-0.05448340355616142,0.7731429757303867,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08060708764627145,0.0970835091839857,0.4095628346572605,-0.2746742572787073,0.11346008198616439,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02741855674892935,-0.0104071627721811,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06419307884999106,0.13431041623906873,0.63436976940549,-0.3326757753527868,0.20428961765280465,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08527248917200851,0.06882235847128969,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06849279063054672,0.14144621053954834,0.6299273645420801,-0.3512397366914103,0.21425415543031687,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0897041177175909,0.05289341295829604,0.96007126858481,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19048915467763047,0.09769568943686781,0.05572327085219434,-0.38578005519886793,0.004801745843606986,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.009719061477801647,-0.07723602150216627,0.5511199060187707,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10014467413494782,0.30797160866936224,0.7461433981413244,-0.7157711479199529,0.5154817996500571,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06871167069213108,0.144927458752914,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09600457478459175,0.08248774357620417,0.24893822119096248,-0.26089522469777693,0.06888607512859345,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00568158161102086,-0.061601335206915096,0.8577318021260126,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10025282138082792,0.21057999614098907,0.6356911185884508,-0.5211962357236639,0.320690592962008,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.031946438689249075,0.05947118858408719,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15639809812470934,0.11232540756441418,0.16878546800360675,-0.3809333884851389,0.06813719223572023,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007081200625616371,-0.0838442627049901,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07735991451252494,0.1397263379272487,0.5818075674941867,-0.35666888420847576,0.20194905518342587,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04543776993215869,0.037346382471725614,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11197294497286553,0.13690090567639662,0.41653955421157285,-0.38563395607605555,0.1616880661303245,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05260977052610782,-0.031624452966914005,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11626521131717747,0.11364407078251092,0.31025268877013756,-0.34343647189114196,0.11090604925678703,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01272923377491759,-0.04809861305851582,0.897405574514287,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00467921407542826,0.17445640653129543,0.978688106712247,-0.3534126016954837,0.3440541735446272,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019548286523057724,0.1419782002111411,0.9984157213799838,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013211698375807468,0.13297121106052384,0.921174920618639,-0.2525939651196134,0.2790173618712284,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09438902487254906,-0.03018598357002266,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12603327886517524,0.1412834104352442,0.3758099472593397,-0.4084547921545648,0.15638823442421435,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.009388990791976281,-0.016511378445566605,0.9164018869766861,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07566725692513945,0.07622607296815556,0.3247297557206089,-0.2280410056437904,0.0767064917935115,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04195063025402943,-0.05540793281401485,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06660125533746004,0.13652928964906808,0.6274003941975026,-0.33951941658674717,0.2063169059118271,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022220742020647055,0.060149765945109145,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07352347895253357,0.13479431155508595,0.5874015211730388,-0.3429734684092736,0.19592651050420645,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11748547489932114,0.05072359778655945,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2614204110409426,0.2120153374698181,0.22222080572302996,-0.6852330318173285,0.16239220973544338,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07774955510238543,-0.19925687798237818,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13970411662250157,0.1258103064366278,0.2710998997640801,-0.3911953357385617,0.11178710249355853,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.053789781491429885,0.06750683547620334,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04819935121159904,0.21938326401655914,0.8268235534981425,-0.4867402472945145,0.39034154487131645,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04179766087994491,0.10598297782342891,0.9807718720364996,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14687887064849686,0.08216444151976898,0.07872454498231994,-0.31112324895946974,0.01736550766247605,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03247481170671132,-0.1101676663130032,0.6337247675321748,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1524722578370236,0.18619850410117067,0.41599740023677867,-0.5246777640494865,0.2197332483754393,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07189659878687858,-0.01868029370063069,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1318658547926986,0.14724956632714462,0.37396956570218653,-0.4262135437761779,0.16248183419078074,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0012941942894647688,-0.009577933717769382,0.915842680969123,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06903400784064681,0.16071866789184852,0.6690243044607479,-0.390306047211999,0.25223803153070534,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.005087178786000146,0.1175674782760922,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01879164293460539,0.12638306666800145,0.8822824079144826,-0.27142779343927087,0.2338445075700601,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09514516313728309,0.06829176042254076,0.9870366109823806,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06437228812737844,0.20555830807507341,0.7552114579163842,-0.47527749105902256,0.3465329148042657,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019952462656871513,0.14756559340194347,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016913107952520292,0.10273152256598017,0.8697676012418991,-0.22227049546338645,0.18844427955834586,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21507299252650364,0.12684408464636773,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12677442935623215,0.10495049894240166,0.2316559550226079,-0.3365674874405348,0.0830186287280705,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.045920164872602906,0.003109601663553646,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08277550610620105,0.201962647874256,0.6833246572588333,-0.4864930867114806,0.3209420744990785,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04181095608743475,0.07641818423014542,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10029623482043684,0.17123754281067244,0.5601937869065801,-0.4425952055457548,0.24200273590488117,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.027472441219192182,0.0512654627726428,0.950784323383458,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04107629489564232,0.12541337571959935,0.7443725400173964,-0.2917740608141269,0.20962147102284226,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08060890762078403,0.053359067017270376,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05731650509039058,0.09263628305868302,0.5383633681083206,-0.24249379636853963,0.12786078618775848,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07255023999087043,0.01931871272400005,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19407543810510747,0.08479287620936206,0.025509330970968306,-0.3635739824949594,-0.02457689371525551,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022397144530138767,-0.14124809289429255,0.3742940281840044,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011724026949687313,0.07149978732008892,0.8702858604239787,-0.1546500652764894,0.1312020113771148,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006205569140477348,-0.003779979837581782,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.22263269757029885,0.10806863568855649,0.043592076411757524,-0.43865882219638014,-0.00660657294421757,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1243390087646769,-0.15602208627238173,0.499126055229397,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01523271228761373,0.10619460714762805,0.8864067142062707,-0.2275127072382714,0.19704728266304397,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.012249278527238118,0.04031047691603432,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11167411746364148,0.12182635012419643,0.36286943828970697,-0.35520152138604594,0.13185328645876299,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04524786353830159,-0.005744507410299538,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03923498204073941,0.09293635874549638,0.6743610298178351,-0.22501211606978264,0.1465421519883038,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0306695716775987,-0.036116529038009326,0.9604862397331528,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.22755927880876756,0.13761508469265044,0.10326538109598299,-0.5026479134235119,0.04752935580597675,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07889033248014064,-0.11020104496021683,0.6839484127328216,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025785834320539415,0.09459456075927691,0.7860717794178492,-0.2148776669446173,0.16330599830353848,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07054795949626691,-0.05831194621075445,0.9723917383541977,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09629256326386958,0.06838876872481107,0.16412055679390777,-0.23299976402975003,0.040414637502010894,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06916084522626276,-0.08809845714494118,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11131379137406222,0.10188747042947553,0.2788329938872626,-0.3149839427051644,0.09235635995703997,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.044725056367260034,-0.031109189461153985,0.8741612580873186,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08095062324285848,0.14579168471749804,0.5807225850271944,-0.3723840484134475,0.21048280192773058,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.005774538379914176,0.020799347407807124,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14237204949432386,0.1504243142035285,0.34758338413333567,-0.44306596905645684,0.15832187006780912,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05276449264810398,0.05995817186080492,0.9086350165348037,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.084935814880537,0.2050058612877296,0.680077598334485,-0.3248650626585302,0.4947366924196043,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04027836142967617,0.1968286836562423,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1012495144670629,0.081552249499233,0.21908676480321837,-0.2642701383660293,0.061771109431903476,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028865620303942158,-0.06965930923523556,0.8337844604918982,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05128409498189452,0.13832468920141056,0.7120863351135629,-0.32779120879800877,0.22522301883421975,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03241391608187196,0.06810579385891291,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05458760241465417,0.12212070423915149,0.6564347784549012,-0.29870341182877536,0.18952820699946704,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.041538909851369946,0.07041183222423582,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05225098527904357,0.17951056927326176,0.7719657332817997,-0.41108750026274105,0.30658552970465386,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.001826804041778725,0.09195357488359238,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11200306404436676,0.14148833232219682,0.43160840234119047,-0.39483421034899135,0.1708280822602578,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.045088424952508366,-0.01770057876557718,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02162239773487494,0.18349226287584464,0.9065767928905127,-0.3884182048196896,0.3451734093499397,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0157276192371206,0.03290931688297358,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06872017001331561,0.07435313003273133,0.3589444120149716,-0.21734995915102462,0.07990961912439341,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013975255948403471,0.02910957065960359,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08217448779844204,0.25759089391042367,0.7507900153783662,-0.5970913477725457,0.4327423721756616,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03789905970972045,0.1010005893053019,0.9646550643928868,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013268795458266926,0.15490767928269708,0.9320157743444142,-0.29638724319758614,0.32292483411412,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.14405104152290432,0.1626833743176483,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05569447011862234,0.2026219705168018,0.7843308839383111,-0.46073001790688617,0.3493410776696415,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10641088754701532,0.05372376997895205,0.9719042392604298,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10689994634080086,0.1461607397291091,0.4672986676211309,-0.39907110196781886,0.18527120928621715,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07338687551732771,0.03600452433398708,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05992481117190123,0.17685412935655717,0.7358770671857904,-0.4134511784253957,0.2936015560815932,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05772528354067816,0.13290988783690513,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04277154742374474,0.14873265449966516,0.7746323884900042,-0.34008388742134177,0.2545407925738523,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01789739169037018,0.05132730355126205,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06556181852728145,0.08940125424063272,0.46611293876353777,-0.2442723793413658,0.11314874228680293,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09239972034968637,-0.05227567024008387,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041896523654872946,0.11173617536257541,0.7089703055789676,-0.2652539556269079,0.18146090831716202,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07441772116669164,-0.06825630992695397,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07384292345334478,0.10305146670342887,0.47633407922103976,-0.2798398701820127,0.1321540232753231,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027290726790321032,0.015626353582154473,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07520332891918671,0.24346363830708434,0.7584412822860357,-0.5618802073283649,0.4114735494899915,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03673061616789965,0.20694463641077943,0.9669418369722411,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09825554815712928,0.057289163830371324,0.0913248782745838,-0.2127749548887004,0.016263858574441847,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1054496227698355,-0.16426708886194166,0.6648373299485711,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02544130569101813,0.10429944018205174,0.808093792599857,-0.23393291585746623,0.18305030447542997,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.045858903558661755,0.009828845104853202,0.974516576191754,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1033675603740902,0.14451897081857584,0.4771379171059503,-0.39225686671140136,0.18552174596322094,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06565177233341651,0.05388272364874612,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08383918114374156,0.1107716887031444,0.4519976020458969,-0.3052686317550153,0.13759026946753217,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026216793687125404,-0.028791679528507346,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12428635584118619,0.1485185452836684,0.40589617032912384,-0.42117069761447135,0.17259798593209896,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11640453778521673,0.03943086634648825,0.9237532919369174,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08436162253133682,0.08348074191107652,0.31615860805007,-0.2512372478323934,0.08251400276971975,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0016473377353009098,-0.0268802749016862,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09507923942038884,0.12955141856470434,0.46576924979704437,-0.35404883512250207,0.1638903562817244,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.037522108635689604,-0.012574725722157126,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12598643149135016,0.2310637454805082,0.5875410015666838,-0.5878762773259362,0.3359034143432358,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017607519437938614,0.09335538589112262,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09261408624591091,0.17629156628660667,0.6012164289014019,-0.44501590594603946,0.2597877334542177,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.020659272950951723,0.005635095779781979,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11985137236420886,0.10895073993169722,0.2755628313799674,-0.33764079824738275,0.09793805351896505,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02674757986716093,-0.055502810402613845,0.8716406527156833,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17832941063840008,0.23945460602221427,0.459247671545705,-0.6569923476992557,0.3003335264224556,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06151927104625425,0.038780069636653536,0.9366557334939974,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03294210660856801,0.13169179618073057,0.8033018736018883,-0.29619025620081346,0.23030604298367746,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02415228531182194,0.09336886731617325,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17411184586262426,0.1635209004013288,0.2911101080596605,-0.5009854682045325,0.152761776479284,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04309628280925369,-0.054685120931346566,0.8793120387281526,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024881011657025665,0.19429964169547134,0.8985200264710274,-0.3635184378620126,0.41328046117606393,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11210097187489518,0.1646312567809207,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010941900431990219,0.18542706140780477,0.9531345759986911,-0.38160531467339115,0.3597215138094107,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2577497450226847,0.001731030537538425,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16774413507746738,0.16632207110538572,0.31711044423525964,-0.5002172178711337,0.16472894771619895,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0913199458127513,-0.12841545702900592,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04464316088826174,0.19334460358788588,0.8181531880706876,-0.4311335164325552,0.3418471946560317,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05814262879502784,0.11849486864210712,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07009509714824132,0.20219935937853034,0.7300181177339005,-0.4742858573083194,0.3340956630118368,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.011565179317347577,0.08573304373698598,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07715137679858132,0.1056506922753942,0.4679880265146139,-0.2883441014119527,0.1340413478147901,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10173078510998877,-0.020194756830571335,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21359710761840722,0.30793298887404236,0.49049365444102966,-0.8291463815325741,0.4019521662957597,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7636580954504453,0.24242192542172872,0.9418332435783486,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021226994097726156,0.15201210503481388,0.8893969437904465,-0.32509486230660534,0.282640874111153,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10221608804516406,0.14091866138567957,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037801021504846065,0.1314248768498634,0.7745933704688875,-0.3005156069573424,0.2249135639476503,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10474465668493116,0.08972966803080526,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15157496283220465,0.10336725530259147,0.14760059834865477,-0.35820316197600244,0.05505323631159317,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10701993063233699,-0.12113429755854103,0.7662201971017615,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07131123753151077,0.12809495744382082,0.5797323056995008,-0.3273694089373113,0.1847469338742898,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03714225299139471,0.07124055770213651,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09901722383530911,0.11177560429634757,0.3791175290380927,-0.3224534731229016,0.12441902545228342,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1532811826163582,-0.09001672969893786,0.9183506089424412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15332745783992152,0.11063805459809728,0.17075824969736936,-0.3744897776815018,0.06783486200165878,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10963856634288671,-0.12133251075735188,0.7844207095472905,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10054977461793993,0.13984533695715332,0.47483791141007614,-0.3800966199852247,0.17899707074934482,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023974795523529168,0.04727832925415321,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02524813904210767,0.10439949136981964,0.809701038844112,-0.23393974868314918,0.18344347059893382,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05521983707962424,-0.06663320267691328,0.9747331744048557,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0789216168581652,0.15662603645742246,0.616127571390129,-0.39201260256238424,0.23416936884605385,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.041397278196287246,0.07101092838954534,0.9561721723743585,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2059731360671691,0.1477536411321947,0.16828450225762057,-0.5013284562283977,0.08938218409405951,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05667117376033574,-0.13784104774174252,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1459106685891797,0.23652394545795813,0.5395621988678905,-0.6187152986559944,0.32689396147763494,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0015810688854524739,0.09552977093147838,0.9473666743227858,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07098325596596079,0.1372115898661184,0.6067687621835074,-0.3452653159151972,0.20329880398327566,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0678770281570204,0.02436921850566744,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023257920584194798,0.11101127724122498,0.8347373990826046,-0.24516630185889926,0.19865046069050968,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06462403498094592,-0.02185278066953552,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06968562612921432,0.20907954444681867,0.7400344904323839,-0.48762968027271913,0.3482584280142905,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0095951454536699,0.1736400634558502,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08105900882015678,0.12034992406611392,0.5031147925605388,-0.3216350791054484,0.1595170614651349,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06786250416095038,0.027959411292043677,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.317670531925848,0.11989601602538356,0.01021271972474962,-0.5573392529663672,-0.07800181088532873,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.198954671438614,-0.19770826665266913,0.20575778978442252,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.256642257969226,0.2136275165468051,0.2341831086110013,-0.6836775788008662,0.17039306286241412,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09192801372609885,-0.11162178697632623,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03560988808590213,0.1007642034147559,0.724988769363276,-0.2370346606485567,0.16581488447675244,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02700235940002622,-0.01878539974724439,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02528528360728498,0.08686995669006657,0.771968914692946,-0.19893585271665126,0.14836528550208128,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10437815457883762,-0.0010504504876414481,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09007275310476585,0.07017421483366446,0.20407294159667963,-0.23034900978744233,0.050203503577910605,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09017380913024088,-0.11866005954709105,0.8179445630780711,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12898112159359892,0.07390485712403945,0.08589896969729302,-0.27671482595497515,0.018752582767777304,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.13435935779115704,-0.06983897867310973,0.6537545747431563,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1900090082987411,0.08034179832633086,0.021173150280695965,-0.3506099747803164,-0.029408041817165748,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.19385215791367774,-0.23882516048700642,0.33504311408065957,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027224904048626472,0.08543086400184224,0.7510420875174039,-0.19799876786386134,0.14354895976660836,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0728683763986583,0.018616344554728676,0.9646550643928868,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07364388605292338,0.06442595009440481,0.2574009420720016,-0.2024295252494525,0.055141753143605754,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.050754693248060194,-0.09319869174664194,0.8657833382065884,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054385229882060425,0.08781006157415751,0.537954665224279,-0.22991504187774844,0.12114458211362758,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03747082009418279,-0.020920424872413045,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17119398939184124,0.08731647235020958,0.05442062637810994,-0.34573713058774275,0.0033491518040602575,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01522258570007871,-0.13119395089559133,0.5461326576351918,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10238182385456084,0.11341594789490207,0.37017313086727555,-0.3290970732738119,0.1243334255646902,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004717302168070243,-0.044508985081094674,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13441711673723966,0.08605023095855242,0.12336007541942581,-0.3064290774575298,0.03759484398305049,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.060916659033646486,-0.07645886428170537,0.7248203395110304,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08480368039282592,0.09405454904682486,0.3707356029715827,-0.27281604498484774,0.10320868419919589,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12000192389667103,-0.02602056321493801,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018857495858569502,0.0630409090743496,0.7658404474860482,-0.1448744775060854,0.10715948578894641,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16567614839522057,-0.15431320948616006,0.9686101294099047,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05817738250231495,0.09227301177908054,0.5306900007029861,-0.24262850483958237,0.1262737398349525,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05815790372934572,-0.04335298516477548,0.9460639469661322,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1709753315097789,0.09906765915870144,0.08935642434726727,-0.369008760427194,0.027058097407636206,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00584915793746927,-0.1422463545131096,0.6623259037556665,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04891389139737399,0.07647542524331676,0.5247872839724648,-0.20178608821177962,0.10395830541703166,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.009242230717971632,-0.003195795491331943,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.24909343808566248,0.08844616443482288,0.006506056685381738,-0.425894801581724,-0.07229207458960094,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.027782035021601474,-0.1998391343293123,0.1556009807507485,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09395046832423731,0.1018329957485401,0.35979551252207864,-0.2975117263197501,0.1096107896712755,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.004455594135383792,-0.030127017466522882,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12296007826064541,0.0885704130378219,0.17002156219758072,-0.3000098111751332,0.05408965465384237,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06312375611086488,-0.10162096765873121,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01974604517781638,0.12358457089626056,0.8735756726114129,-0.26678808234423346,0.2272959919886007,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3580977464113995,0.20482126087528157,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1979627640882593,0.07363797324166209,0.009210289844567733,-0.34516297517040795,-0.05076255300611068,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13390347933599983,-0.19935210598066452,0.1972100984392524,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11985576732154223,0.09168397576079215,0.19240939063088658,-0.06077978158652757,0.300491316229612,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13344975684686572,0.29413457815542243,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14027233936980923,0.11261338037061533,0.2141587640286594,-0.08159827224843627,0.3621429509880547,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09235733785852165,0.24391835200391965,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2280188804608498,0.06677013903179649,0.0007523113877363316,0.09646851285741415,0.3595692480642855,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.032767125317647375,0.2775195062258137,0.028989552407043692,0.27704431880498176 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08053037470855055,0.11668555052102499,0.49078756746932006,-0.1493632167626353,0.3104239661797364,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.187177694220206,0.32128481889957,0.9419198731133068,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09587538823788316,0.08985722361799595,0.2870875260031767,-0.08116109798453358,0.2729118744602999,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19213995819091428,0.2907591614744614,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2554682372504214,0.07941269397237913,0.0014794570916679454,0.09900953825818509,0.4119269362426577,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.04866872360085526,0.3261259915257902,0.04997417188791553,0.4775879328570332 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08337340907372601,0.09351963118991784,0.3735769218166818,-0.10087874375334613,0.2676255619007981,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17185387165211707,0.289096758999981,0.915824547329523,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21347716875937997,0.09829100006239996,0.030873283816991896,0.019824476435936433,0.4071298610828235,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13150394521191897,0.3134902363680174,0.42002168600416523,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11963002533159181,0.05304692945512342,0.025051375194060036,0.015117092286299497,0.22414295837688414,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1053557368465991,0.215637279449691,0.3733081872128039,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07533970969349517,0.10786207125758278,0.48557239198243285,-0.1371698841182824,0.28784930350527277,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.18150433583045486,0.29678900194787483,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16732468723305846,0.04145833336401498,7.378029720449574e-05,0.08564357838191798,0.24900579608419893,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11992544128112197,0.3176260493941364,0.003730369421715205,0.0356500038641133 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05493085946191975,0.10614105844569964,0.6052793354410309,-0.15418799904008657,0.26404971796392607,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.18179121768208342,0.265403772641461,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14622971587690758,0.0794619020205367,0.06700346171333926,-0.010325932693658835,0.302785364447474,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11930625428228896,0.27978879694246583,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13634654694097745,0.07254677285555013,0.06143397181741178,-0.006584930752154938,0.27927802463410983,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12583178903213837,0.24286120966438798,0.5784562420554139,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01996289942217283,0.07647352295948526,0.7942897103675274,-0.13070505189749346,0.17063085074183912,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.038112718684805744,0.04345069777332306,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16003534489115248,0.12908198127153028,0.21629799481530487,-0.09428166468049479,0.4143523544627997,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.056965278256045165,0.1010231307777389,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.081777703612733,0.06457759004815136,0.20665305767540892,-0.045452909247497744,0.20900831647296375,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07038694911365545,0.13148127801621146,0.8206162940607284,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17833606273331995,0.05715895518622034,0.0020366728898343163,0.06572162646571163,0.2909504990009283,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14183044516486124,0.3610233962195971,0.06441079442033786,0.6155543353451172 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11196252194025828,0.0790718016550218,0.15812254151695954,-0.04382455182681279,0.26774959570732937,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1063809319465681,0.22880745348122195,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11136804862642906,0.05364125256379696,0.0389756170169307,0.005684181619414877,0.21705191563344323,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08870336132857048,0.22948194794194318,0.4740874443660114,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24938212282271044,0.11966349413444362,0.03824749861823477,0.01362139399449483,0.4851428516509261,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06895084941405953,0.31780667914019495,0.4714419938378068,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1629103956281092,0.07606178107250987,0.03324569338853923,0.013053657185557788,0.3127671340706606,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12861283005253207,0.342348537714292,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17812318530100726,0.0732432653607203,0.015772871328842235,0.03381947974648697,0.32242689085552756,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.017132844869104435,0.15114102249360434,0.2751759397985707,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009428505357194271,0.1516080096836773,0.9504648235763055,-0.3081262420208164,0.2892692313064279,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.18762451023199084,0.20517319678456675,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14876579455219005,0.07102265869027949,0.03728488442118273,0.008837122928032265,0.28869446617634786,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10354290874297788,0.2527307705753527,0.4631727895701855,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.161972413329249,0.08631589265255094,0.06183559468107034,-0.008086951127884712,0.3320317777863827,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15314968247617228,0.33724739270688836,0.5795602425469765,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17056734403238402,0.06862225302917553,0.01363602155220463,0.03536794587829073,0.3057667421864773,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.01696982694187771,0.18388369482015302,0.25114324612853905,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2087564455483719,0.09257716831127101,0.025065918844094797,0.02636113082192948,0.3911517602748143,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1645159978533958,0.4051734319293246,0.3733081872128039,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15832571926675798,0.08524127925724945,0.06451841650705405,-0.00961644445913018,0.32626788299264614,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07098742829719756,0.2246861814824587,0.5880149074273526,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07442905461362778,0.06464780660018395,0.2507886677986816,-0.052939898728825624,0.2017980079560812,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15995491680337423,0.2558335332396128,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07530408201095079,0.0785488745447646,0.3387082703628411,-0.07945272201905446,0.23006088604095604,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13150587241107334,0.18072201870931165,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1569549462544443,0.12194830872907149,0.19935005689933533,-0.08330731880220207,0.39721721131109067,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12008584797731087,0.28813082521162264,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08466270362534394,0.11199580314034657,0.4504455518033439,-0.13599115881664664,0.3053165660673345,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15411122412381562,0.2687889331383311,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1373822891969491,0.07668458046032098,0.07450691079717624,-0.01370148710410865,0.2884660654980068,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.05823203221300191,0.2005482652656728,0.6251964671331764,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09935650757215501,0.10839705776391349,0.36030114775201205,-0.11420711536987747,0.3129201305141875,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09904322775785213,0.20049320022389175,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11491926061421727,0.08470974521929288,0.17621372187744674,-0.051975676026317266,0.2818141972547518,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19253412423399913,0.339565680638477,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06230292690576786,0.09879097603216741,0.5288848419944132,-0.13233481687285495,0.25694067068439064,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11060231894565442,0.160981785149692,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03709401014806032,0.06202971717020199,0.5504181646438857,-0.08511678968555009,0.1593048099816707,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.22769016253257882,0.3061411220194349,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11638497945013655,0.050033548379309886,0.020870126341914756,0.017809002565198073,0.21496095633507503,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06841554665730257,0.180965793648805,0.3333341305877653,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07441442495745777,0.06374767014475854,0.2442712502052233,-0.05118108170176981,0.20000993161668534,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13599648396296837,0.20733502706706858,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1714057060883382,0.06143941657756066,0.005709961807250491,0.05035791506502116,0.29245349711165525,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.0700657144124973,0.2448730571147069,0.14434928925463184,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042890683558262116,0.05104253607586522,0.4016055846227793,-0.05767319846382142,0.14345456558034564,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1145550919986085,0.14815407680097376,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12221725493291379,0.05766332394183991,0.03510648216876727,0.00860911255398758,0.23582539731184,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10478069856398141,0.2231746302697635,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08787057374347783,0.0825590660219598,0.28827833555871074,-0.0747870999063132,0.25052824739326884,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1497492572198856,0.20472221208176894,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08587098333081837,0.06365818144446214,0.17866616384929357,-0.03954821290595019,0.21129017956758694,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07758627779845766,0.1698640398552838,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08410496474534086,0.06896292739531211,0.22386184497652384,-0.051765629226945845,0.21997555871762758,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09201965089587313,0.16885803835658364,0.8356888710841501,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0907403031946963,0.0678430836311767,0.18236274171066058,-0.04292397728226767,0.22440458367166027,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11391145871802043,0.19192764381322405,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.068455411044276,0.047277840494473866,0.14897845697681666,-0.024691276782491847,0.16160209887104382,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.055717195174954534,0.11755615947335518,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1004693641334813,0.059223619175184566,0.09113794663962428,-0.016212868167867156,0.21715159643482976,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08860568519630387,0.15616069115025208,0.66475521554025,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10061704859719582,0.08208995654566768,0.22155182787639982,-0.06111638668874973,0.26235048388314136,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11480375867449807,0.22347593948027186,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06603978072250645,0.06697215168623734,0.3251175814801446,-0.06590859172767045,0.19798815317268337,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.07531672794464803,-0.053121098255111875,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1534906646462953,0.03838083162773365,8.538202328263983e-05,0.07787284232680677,0.22910848696578381,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.23094235873786273,0.3968981911074089,0.004236015630109969,0.04048231059979825 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3132419035669142,0.10512732775478602,0.0031914002689833326,0.10612029483814961,0.5203635122956789,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06893266591869333,0.41127903230744006,0.09145608424256206,0.8740179290727966 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16775543954692507,0.06411315459343866,0.009463143660696035,0.04143985630444649,0.29407102278940367,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12234302429333217,0.3342562524424017,0.19872601687461675,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14859904268460422,0.07435456217053783,0.04682248199657209,0.0021058628236368115,0.29509222254557166,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14483277176589437,0.31014665150302356,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017297034526085706,0.14268106354371715,0.9036144030640773,-0.29840692333861085,0.2638128542864394,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.244013747117123,0.2268877458922073,0.9884099671383002,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16754683124544895,0.063694298417071,0.009094823533069438,0.0420564774359643,0.2930371850549336,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08590303756743348,0.24202287616548862,0.19636616606057228,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03370237764055106,0.13298087633444886,0.800153418410496,-0.22829622562270008,0.2957009809038022,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.20574920884878073,0.31702693613934535,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10819580757997391,0.07052815659035001,0.12636677626623105,-0.030758597194216503,0.24715021235416432,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12206409384747158,0.22128913452002105,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08474245680313164,0.0900955989115319,0.34789231725991454,-0.09276367585026377,0.26224858945652707,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11631672595054388,0.19401940851882996,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10352879001250716,0.044198437007181686,0.020004983480343207,0.016449135542666693,0.19060844448234762,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10678143507366049,0.18675182227673642,0.3247434741655713,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10480222375912623,0.08390361214805112,0.2128896677244708,-0.060504471439996294,0.27010891895824873,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.006424212226480463,0.11055235471111788,0.8287975391843301,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1120698384733124,0.08557378509189968,0.19161150898615587,-0.056527427449647644,0.2806671043962724,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13522711358839598,0.22359176524612198,0.8125064948355263,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2081705721582142,0.09856004785272887,0.03574095465829469,0.013987802524256049,0.4023533417921723,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11814048112740193,0.36465209780631247,0.45290755634531366,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15178599997994777,0.09161566993183556,0.09891212287211433,-0.028714972947916,0.3322869729078115,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08423609627570493,0.2417649359093566,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15920906809704935,0.09046182060765977,0.0797270030759391,-0.019018593662748412,0.33743672985684714,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11404279769425982,0.2776169826633408,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15441064689633383,0.10199276453242634,0.13139703996920032,-0.04653525289791352,0.35535654669058114,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10045158921458015,0.2655451340932474,0.7364614878814166,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22596927772793415,0.08204462131875916,0.006347438821098188,0.06432516179719261,0.3876133936586757,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17529072271932641,0.3949905070245512,0.15361576024962625,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1272936284189617,0.0816535945720884,0.12036612844077087,-0.033580087554355514,0.28816734439227887,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1228927659928079,0.23451550767591636,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12125130969679425,0.07244832675501962,0.09554628621555532,-0.021486209725444835,0.2639888291190333,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1301451159349255,0.25452141940139256,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0625582613863226,0.07171194989761608,0.3839129304764035,-0.07872845011952188,0.20384497289216708,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15129353110075014,0.2202781134276817,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05737943783966672,0.080840436595705,0.478546356063965,-0.10189219624099541,0.21665107192032887,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16869885741462745,0.21592895337893417,0.9377193222502479,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07477260438414857,0.06202805209540601,0.22924689346532912,-0.04743491492309669,0.19698012369139384,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10963228116425108,0.165108394613424,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16368099100828654,0.08109939239523899,0.04470858506619757,0.0038991628331427886,0.3234628191834303,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11876931110290412,0.32316389015531394,0.5055162930315735,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1088930228619975,0.042277082717044105,0.010621671655166903,0.025598816001359603,0.19218722972263538,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11339974718926672,0.20792983312124802,0.21078707399678717,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03452840046147253,0.09747945691670734,0.7235003008312473,-0.15752539150486566,0.22658219242781075,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17111831459696603,0.21122738491947568,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09168057405418968,0.04589193826565002,0.04690660815225518,0.0012643874710597663,0.1820967606373196,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10569600726366607,0.17738994941064987,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06133723796906754,0.06959697126961874,0.37905258735739467,-0.07578254772202064,0.19845702366015572,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15281908141222975,0.21893014521183835,0.9183506089424412,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08961812152821787,0.06145471452067531,0.14611026415761047,-0.03145980946589284,0.2106960525223286,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09416292029241405,0.15137592713702722,0.7660655725780131,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07996341123237839,0.08203887982844729,0.3307192366741871,-0.08166939282793621,0.24159621529269298,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07209715436767085,0.1658082464551308,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055811542929488554,0.08703613688413893,0.5219933540685984,-0.11566684498339286,0.22728993084236998,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1282837996453106,0.18987025192562706,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05120995088402254,0.07088284653764938,0.4707368141573818,-0.1908631649407615,0.0884432631727164,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08559496586390608,-0.022364269073111474,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09867583497873746,0.0780172720670365,0.20720848913707118,-0.05503360712604062,0.25238527708351555,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1055055659060834,0.20444037782912217,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00198345084019406,0.0684646303034582,0.9769129603688959,-0.13687230107853574,0.13290539939814763,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08329322905849279,0.044922607348525656,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14372973141938858,0.05873961053983527,0.015149294291327957,0.02800109176928675,0.25945837106949043,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08519623113657662,0.24831790138043935,0.26949433460657995,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11958830846129911,0.07683107477541798,0.12094417416600035,-0.03178409058762571,0.27096070751022394,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10681556423940002,0.23931357054739352,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11288955882463152,0.12934256036779204,0.3836733078352865,-0.14194084305681282,0.3677199607060759,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08444452398166977,0.19379921690968488,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19048577436625427,0.07980724948834594,0.017793648288451373,0.033249723043799195,0.34772182568870935,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11590379507094946,0.3605810118073917,0.303536876132493,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11523629422514513,0.100033781201702,0.2505124571450485,-0.08185002131448403,0.3123226097647743,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14760201513781943,0.2729039291501309,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11771768214190426,0.04562499019144493,0.010490610221785244,0.02782743601362328,0.20760792827018523,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.04909293341546718,0.1568654560372447,0.20923232145862128,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1252431206303371,0.07945412985526623,0.11631465324156347,-0.03129721523887463,0.28178345649954883,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10946003567314655,0.2546233073580179,0.7174092598535593,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06246182616878115,0.07488025459570924,0.40504736429260446,-0.08506707164605645,0.20999072398361876,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12218950202863403,0.17245906738817757,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18672635343143928,0.0615981290056065,0.0027096604527017815,0.06536586756345941,0.30808683929941916,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09337995746653585,0.30371403875641384,0.07966401730943237,0.7613247386116051 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15595178707809068,0.10365062463135637,0.13378360494912328,-0.048260424702499194,0.36016399885868056,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13859572852707583,0.29584752023190625,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09096028304382779,0.09974043970450436,0.3627271269234823,-0.10554809178234388,0.2874686578699995,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14578027308735314,0.2698823367642111,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1415871850429061,0.036897236473518676,0.00016021965078874558,0.06889233833409761,0.2142820317517146,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1127350462852534,0.2680077587624802,0.007254849161155216,0.06933238277238057 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17890367996030584,0.054412825815403174,0.0011653997336180842,0.0716996611855465,0.2861076987350652,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.04864342865220357,0.2539674973271523,0.04111530260204601,0.3929264185216215 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1517683098501019,0.08524108851052756,0.0763037828929475,-0.01617347806705277,0.31971009776725656,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15226917584027488,0.3116555819785053,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13131981229561956,0.07360965003301256,0.07572456144736689,-0.013705743460550868,0.27634536805179,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11389233005357838,0.27380274747398486,0.6287673313485338,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11196452359094893,0.04592491221997097,0.015517883105481422,0.021483371802187276,0.2024456753797106,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09969552062926881,0.19489529170314837,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14493115136805504,0.08299000176903212,0.08206473377847964,-0.018575550855928852,0.3084378535920389,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14272267476449296,0.2553187568354982,0.6430699474171485,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12649598564141526,0.05636035675460051,0.02574521252411891,0.015454946086326707,0.23753702519650383,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.042222816391601095,0.17042799486919843,0.37636371457910855,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16021762781065474,0.08267836314247728,0.05385081316904952,-0.002675084739544059,0.3231103403608535,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10018829917206545,0.20972069828902704,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1279255189975982,0.08849517659058564,0.1496429435846187,-0.04642746544172857,0.302278503436925,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.027592091038850658,0.11672272611229569,0.7663649588223891,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12148967152160194,0.08888217201129665,0.17298591174125538,-0.05362577036642259,0.2966051134096265,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11276241134539382,0.19853962001103406,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19243233210296304,0.06927866634007519,0.005921097239525215,0.05593967001980232,0.32892499418612375,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.008026690279421093,0.20208081544780856,0.14734065795407886,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11544682886581624,0.08199764090391473,0.16048498815903217,-0.04610472636440015,0.2769983840960326,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10891818077502612,0.16439104929591938,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17046881905426953,0.06670425107462541,0.01123720519093458,0.039048263745853434,0.3018893743626856,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.02322688385748887,0.1680721557355071,0.22034340329509305,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013980131938340727,0.056699095719525715,0.9803498881313052,-0.11031040905662819,0.11310643544429634,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07230386661217256,0.035524113974039456,0.9985296925363316,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010376723314280672,0.07694850592896804,0.8928446591365424,-0.16198048493997427,0.14122703831141295,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07570948343781636,0.017119161624397285,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06826014780193793,0.07010214591886411,0.33120335760023656,-0.06985493177015475,0.2063752273740306,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10530832045162898,0.17677161799468918,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059798914381597845,0.07716022124923654,0.43912741773318953,-0.09222196825975423,0.21181979702294992,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14135673078558122,0.19112071069736153,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2632392911480158,0.08452417497566518,0.002074373338399263,0.09670996455591713,0.4297686177401145,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1502084578302297,0.45337441356183883,0.06508448838028992,0.6219926232357781 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10401996964645836,0.08434833347189277,0.21873674940502766,-0.062162914437108405,0.2702028537300251,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16991513874992278,0.2809817399115418,0.8335728837144069,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0963682131646639,0.04502660468347447,0.033373442422756194,0.007656904727445624,0.18507952160188218,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08885915105706148,0.19141560417027872,0.43572102952605046,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15380437430123375,0.05891098770226174,0.009619297797140434,0.03773808777720075,0.2698706608252668,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11200365474140729,0.2711370575110764,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09897991734697383,0.0780847691960278,0.2062076990037551,-0.05486250743928038,0.252822342133228,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1789337287123588,0.2614856851979967,0.8201610583485497,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18578775870058875,0.05537703023465907,0.0009265528290105168,0.07668406669409378,0.2948914507070837,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12957393163646225,0.31631380276235443,0.034050816466136495,0.32541327717506013 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10134412126531862,0.07619633906046072,0.18480579919899318,-0.04877772300201598,0.2514659655326532,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11484420716448485,0.20156638242411534,0.8047111541643488,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16580369949547116,0.06882092227709133,0.01676425873701582,0.03021288366614469,0.30139451532479766,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13120630024761176,0.28476453992365497,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.245631252998349,0.04920718716797761,1.1717337081946889e-06,0.14868337098786052,0.3425791350088375,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.05378456201871427,0.2990714049012314,9.588888840875711e-05,0.0009163808877475568 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10842421045767181,0.10914541508898264,0.32154934608503877,-0.1066138242893846,0.3234622452047282,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19622041369353813,0.32023987197709125,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2046119179829034,0.07453870673501889,0.006521942881006634,0.05775593694313175,0.35146789902267506,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14964415399996625,0.39717810293695255,0.1556009807507485,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016462821772685675,0.15957618877328153,0.9179200384363833,-0.3308594457468206,0.29793380220144927,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.129841248889651,0.10419519674050134,0.9901412236863718,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21316089297796695,0.08847421983496186,0.016760019887908224,0.03884919748825241,0.3874725884676815,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11165678950624372,0.3624315891742477,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019327053765939496,0.060222809047621735,0.7485542767072708,-0.09932378002300127,0.13797788755488025,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15177652079845308,0.19697262484267636,0.9639882946953788,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08278487720466163,0.07974361458243327,0.3002819382237926,-0.07432580077895351,0.23989555518827677,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14645229590852468,0.22148215581373817,0.8874303892853559,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19171741654128074,0.0763203387535062,0.01268198779241356,0.04135126837643474,0.3420835647061268,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.03290088258767514,0.15626310859657858,0.2385535997539783,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08859003173656015,0.13579887410858824,0.5148107041290872,-0.3561406474483276,0.17896058397520725,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.23646213105202066,0.050314714477324704,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09476952625301321,0.06962380978221722,0.17477634901290826,-0.04240313661115644,0.23194218911718287,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10192051326186394,0.1935171045064856,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10408316542012558,0.1018874438375341,0.3080531920936479,-0.0966552317939231,0.30482156263417426,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.2067482557981945,0.35709419662081526,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10094888776757545,0.03081253889880263,0.0012123934254255962,0.04024209761093994,0.16165567792421096,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.06530126434076516,0.022399656607055982,0.04239638330849508,0.4051693164687506 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08946210611886095,0.06676499876229458,0.1815652127679021,-0.04207813413794399,0.2210023463756659,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08532298483320229,0.14812225208840535,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11557930249272319,0.0644960347181833,0.07442444614264145,-0.011490630252221162,0.24264923523766754,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10094551719038033,0.2522770699172266,0.6251653475981882,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054938185855869265,0.0885301765944587,0.5354964229296445,-0.11948375550705218,0.2293601272187907,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07393072674101293,0.10174959371567463,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13150241028370394,0.053916497329610076,0.015475669188193982,0.0252762566999553,0.23772856386745256,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10901128554533239,0.2812216378680729,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03188789881143943,0.06378275834054184,0.6175853162770722,-0.09377673852687267,0.1575525361497515,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1337791575200367,0.12244143763536276,0.9570174945596325,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06774918887838657,0.07612878427668705,0.37442210698887546,-0.08223955911615813,0.21773793687293128,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13439977909522263,0.20100734400207568,0.9159127256227925,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21150709850127877,0.09539403185519028,0.027575723858614735,0.02356200598397637,0.3994521910185812,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1437411227421191,0.3839298072381239,0.39228691037577734,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17904519498116578,0.08551279509686642,0.037360601832590275,0.01056809139998155,0.34752229856235,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10256426052526071,0.2914083180258734,0.46338821460484625,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07091666148840864,0.04242775820183821,0.09597162987880596,-0.012674405850594456,0.15450772882741173,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07027298539448505,0.1303267163902289,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18038953904926175,0.09141723789300041,0.049648421986828034,0.0002795164478700263,0.36049956165065344,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11939319522213407,0.33163365265733014,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09165071056926756,0.07382298294099034,0.21567205806522438,-0.05379515316998228,0.23709657430851738,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.132883604150304,0.230860029419448,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19535876665474192,0.06794777134050996,0.004412483912675421,0.06148823070420775,0.32922930260527605,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07959440375047622,0.2845390922450762,0.11833208546897803,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13480483105539173,0.08892783446470215,0.13090258954341683,-0.040400574888695445,0.31001023699947894,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19963658076418975,0.35882615349142594,0.7360778123788349,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10040096901337081,0.11368164089973146,0.3780511582611752,-0.12357432693441528,0.3243762649611569,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.016818434860036237,0.06587501019846277,0.9171668992289758,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1443439520590306,0.0789226911197255,0.06868854407240724,-0.011149344489418345,0.29983724860747957,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09400864588006344,0.26350465925846545,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16378072190274248,0.09173886064135346,0.07551456290335601,-0.016962961065229043,0.344524404870714,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07783243613347876,0.2893358539246434,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08123458020317303,0.10193220477313913,0.4262930545651573,-0.11959200489873237,0.2820611653050784,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13449005567654598,0.24734602782909473,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19847850262698938,0.07435976040984092,0.008138745076382854,0.05197508120742814,0.3449819240465506,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.011243639882921158,0.19494055511726022,0.18301801251084163,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.35912516766031566,0.33742859184984225,0.28829464689868256,-0.3056758338265626,1.023926169147194,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.4266809307844373,0.8516360144348635,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04876276880206752,0.09437749407306434,0.6058710539530208,-0.13717954341762656,0.23470508102176163,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17067783926906768,0.2517383998317953,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06537592853262529,0.07942619746766741,0.4112911454999675,-0.0911093750136057,0.22186123207885627,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17383014592846652,0.2633484376962916,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14295315584443613,0.07154467211626388,0.04686865621227641,0.00199601462177304,0.28391029706709925,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.05047457998875105,0.19835763950246638,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0883286975034814,0.07772354183535447,0.25693695305739833,-0.06480203800409144,0.24145943301105421,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15060100451416905,0.2407256240510758,0.8649556969336845,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14025076999810315,0.0895718000956895,0.11875452405642098,-0.036223375485975456,0.31672491548218173,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.057880818293774054,0.18466762131420666,0.7212497413617978,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15083695580555398,0.09073791969370136,0.09778999186013244,-0.02793467571064115,0.32960858732174914,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06186838208337288,0.21624105076657704,0.6772213442508546,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0865829110664211,0.07712405572700169,0.2627439180232348,-0.06536671834985833,0.23853254048270053,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09516123289888595,0.18505556631505546,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02421213219005864,0.0663120592130787,0.7153499696055949,-0.15485999203451925,0.10643572765440198,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1198238576638391,0.054513851907576585,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09246042616067385,0.09376778501379125,0.3251277389299938,-0.09228063873436926,0.27720149105571695,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1587879647319978,0.25235743360891955,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15491911387248883,0.04377684856086349,0.0004850268290813727,0.06867007194733858,0.24116815579763906,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.03840210941092264,0.2031807866066011,0.019543872940344854,0.18677483838120149 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19940897093657578,0.11117075592276857,0.07415484948908407,-0.019619385458304522,0.4184373273314561,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16917037680087033,0.4099941352929603,0.6242218401318658,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1440375525039883,0.07675968498612545,0.061840202247075975,-0.007194194553481303,0.2952692995614579,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.097928236400515,0.23975051443348666,0.5795602425469765,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09597901960184588,0.08543058277999446,0.26239254745499097,-0.07233610947003136,0.26429414867372314,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1331148122176946,0.2271079315894656,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14837040841322519,0.11527793931349967,0.1993481362482993,-0.07874991083660896,0.37549072766305935,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14810116625513228,0.315501989389785,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1097759351995932,0.05845845649753687,0.06165144822617039,-0.005398775431431205,0.22495064583061758,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16313508665268459,0.28721937228487643,0.5791588118572077,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11594476130561926,0.16569599830423584,0.48478528364644824,-0.21050909671256451,0.44239861932380303,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.016922540132795847,0.10272682767615024,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11016263274012209,0.09899335681244557,0.26692885788227805,-0.08487384116588273,0.3051991066461269,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1559973006181178,0.26977400891036313,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00743940683963749,0.08209604581660572,0.9278737166428774,-0.16918483919256463,0.15430602551328967,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1130868735318356,0.07882717289362162,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12376655686578926,0.06478603598950697,0.057310747173138936,-0.0038747356876156352,0.25140784941919414,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11434987099601081,0.22272684698237175,0.5602619594339617,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05371178666835154,0.0836872211075021,0.5216236502677429,-0.21859214875894545,0.11116857542224236,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1337186509098624,-0.0030766433643655685,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11505828011135975,0.08618174144063256,0.18315780700858417,-0.05473677995015326,0.2848533401728728,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10395936617622992,0.2221086654045237,0.8023767505707181,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07668198589322477,0.09043367856953974,0.3973437331727261,-0.25485420227708827,0.10149023049063875,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11972788272796392,-0.0639858855516934,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08681696609603465,0.0740563315751104,0.24226990650864866,-0.059088640561881844,0.23272257275395114,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11133892622146574,0.17681187721900754,0.8494428082445464,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047677315886761974,0.07628162850022269,0.5325715038890866,-0.19796719720353323,0.1026125654300093,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13575576339659534,0.025909727891925798,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10397403729097347,0.07467831481145851,0.1651612814410439,-0.04315699924579654,0.2511050738277435,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08756981484607843,0.15476959508831603,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015962909722763562,0.04825113613964961,0.9736367444180363,-0.09666056354225883,0.09346798159770611,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09482940766644944,0.07627576849028592,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030249739993900574,0.06880652139494745,0.6606091318575869,-0.10531270325200293,0.16581218323980407,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12278779225043585,0.1339465821443878,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0029646227985941236,0.06335875995934169,0.9627198435316275,-0.1277938995442979,0.12186465394710964,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.0930662051402257,0.08362045622177054,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09976119381637052,0.053301364915010814,0.06250885033026335,-0.005253027361085141,0.20477541499382618,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10413652301550345,0.19871264863475455,0.5810248874960544,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09531116389516554,0.11277777911168013,0.3989088084443764,-0.31750567351833087,0.12688334572799975,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16728109573256914,-0.043765775826262406,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12660851999642744,0.06825996040473821,0.06488821594110031,-0.007877090098874384,0.26109413009172927,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.060844690226611126,0.16411395295759365,0.588665895017662,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039940400885650346,0.05420000291301601,0.46191982025034883,-0.06684431471781967,0.14672511648912034,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07950724656131208,0.11463734071854344,0.9370609591482926,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11631457582020528,0.06992159168355504,0.09755676404275333,-0.021444776230997317,0.25407392787140787,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09271300260190694,0.17289592085060415,0.6772213442508546,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019731395395227343,0.04900423215695757,0.6875772759851836,-0.11627941593030491,0.07681662513985021,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.0994297699200997,0.0835926997743843,0.9632925656593531,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08073629662010934,0.07651150693671506,0.29241870128496,-0.07000649064029449,0.23147908388051316,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07944480024360207,0.14816625215569187,0.8801800464438181,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06851277926917002,0.06489935166091336,0.2922090018170601,-0.05935176754796559,0.19637732608630562,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06997639797196951,0.11639981755982412,0.8799526010712531,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22377084576267856,0.08845085879155892,0.012070360107910075,0.04950517614458594,0.39803651538077117,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.2197158072808223,0.5223751460579893,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06279889077616002,0.07439774607039489,0.3994811835479066,-0.08377936990061999,0.20937715145294003,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.016822466962316308,0.010581322546273956,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006419626274114722,0.12643634502940737,0.9595370363745601,-0.24231448893544377,0.2551537414836732,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06621141898262324,0.109534089653939,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037291242991096124,0.15812946773405567,0.8137147801966479,-0.34837420917649664,0.27379172319430445,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.028209879662149866,0.019392291632308874,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047975662885301334,0.07352724653965567,0.5145460826864177,-0.1926234270039384,0.09667210123333572,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.018199137784080374,-0.006971733560578074,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046586025678629205,0.16149781648934958,0.7731762359504093,-0.27112338361670446,0.36429543497396283,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05325527488802479,0.13102048267176367,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010090562915665634,0.10087324196854744,0.920380322936109,-0.20853521570542013,0.1883540898740889,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09338199109707981,0.06599426848385495,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11843078561865256,0.09338829620433432,0.20564769755098183,-0.30215054770059624,0.06528897646329115,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06559499583498754,-0.030042056276512415,0.8194936863251474,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09677219888885621,0.12081502879789774,0.42371809528314697,-0.33444768124381524,0.1409032834661028,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06695930013275722,-0.017559431304913893,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016582142863230783,0.08737721179113533,0.8496023665906296,-0.1884764938055274,0.15531220807906582,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09775982397684507,0.06546365059816817,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017966962254319964,0.08934474448881145,0.8407481185712402,-0.19373197637173856,0.15779805186309864,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04244265647582276,0.017582476141464447,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025028193007659332,0.1589653073848437,0.8749921156349244,-0.28769909337655325,0.33775547939187195,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04812108929792848,0.09253890679712207,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003632948676730901,0.08395342816187334,0.9655101027127299,-0.1615259039284746,0.16879180128193638,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07670298657044866,0.11411448916564575,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03244899698520132,0.16192593528345603,0.8412973531760974,-0.2861026365094469,0.35100063047984953,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.048215492049292166,0.08729425852910172,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0443595334086901,0.11546280262727937,0.7010888762398934,-0.18278668822902372,0.2715057550464039,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06264865663292267,0.12869507671156413,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044017226652312655,0.10999156927987931,0.6892806883449004,-0.1723656153143575,0.2604000686189828,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06661205403908087,0.10486054101192926,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043380853302158975,0.1622186330290487,0.7893132614022434,-0.36250830156555025,0.2757465949612323,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.058638004625385015,0.0516836181177098,0.9727286373504853,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12683256536954335,0.11948681730559238,0.28925869398134857,-0.3618951003929981,0.10822996965391143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.036022470418822825,-0.10181785501874856,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04258294122637975,0.10928633988942481,0.6970530555044979,-0.17241252586470635,0.2575784083174658,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.01750774301991059,0.04661920908649366,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048165033509608775,0.09901368190301599,0.6269762315017591,-0.14662136715753485,0.24295143417675238,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06592822664834058,0.1413129717384082,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013377830841380466,0.12144800056470612,0.9123560153798638,-0.22554287631292794,0.25229853799568885,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03499955295221479,0.056504676237275536,0.9895179737785706,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015800546572278855,0.08435818843378676,0.8515395442525491,-0.15015457777016283,0.18175567091472056,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0396880803275394,0.08577179603923894,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056060918837943334,0.14108617994657877,0.6913677152347626,-0.33361517848651734,0.22149334081063066,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.017597082636061304,-0.008342934327109931,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08952325757262454,0.11915355622802912,0.4529980425463147,-0.3239301789017559,0.1448836637565068,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.047031984653059196,-0.004569378083340732,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0072490770255082245,0.09506536556412704,0.9392641092001306,-0.19426808319154878,0.17976992914053233,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.03411611561877194,-0.03488674387966933,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020078869751380277,0.1525495292999669,0.8953644993288818,-0.28002686477642946,0.32018460427919004,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06902436260473498,0.08846836522089191,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0027033345661921053,0.11147382210874682,0.9806673573964779,-0.21659549525048646,0.22200216438287065,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03793854162408856,0.04781000326948154,0.9985296925363316,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08662254375273197,0.0697634988242773,0.21525464236774414,-0.05062092172346257,0.22386600922892652,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1254943422036502,0.2250008453444671,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015126285845816932,0.08741825146743695,0.8627324793685143,-0.18710137281042574,0.15684880111879188,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.0014691744500724018,-0.001991932261791057,0.9850935588646815,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051420592444764004,0.06572164515563018,0.43454766605275086,-0.07787146557937534,0.18071265046890334,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1550446701413335,0.2239540027934016,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04810973313811974,0.09841252672012273,0.6252710693425829,-0.14549403446187992,0.24171350073811942,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03184639599924867,0.09486700974160782,0.9596677781209249,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027525664945372914,0.08807347838573124,0.7548370632087584,-0.14573842865530648,0.20078975854605233,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09517412169121545,0.12058649780745398,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08101641494271888,0.11401921557894044,0.47787081089748085,-0.14328988477924318,0.30532271466468097,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07748977209067488,0.1557137263287411,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06046434401139439,0.13230457827028264,0.6479691642498489,-0.32074284388877083,0.19981415586598206,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.01745432134239765,-0.03253655111641918,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06277057248521395,0.13978026006262043,0.6536823715855182,-0.33775573835940376,0.21221459338897586,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0397025111800134,-0.01518200162909603,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03289205230246284,0.09604480215709797,0.7322211322794705,-0.15605376766304202,0.2218378722679677,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.015279138540119535,0.062920277912941,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019723826997877024,0.13698163098843535,0.88559824485609,-0.28920334078757115,0.24975568679181712,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.009753867418065878,0.007849040839417022,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062432775687239546,0.09607686376720236,0.5162653901731359,-0.12657611804253502,0.2514416694170141,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.118311876157498,0.16823171382476348,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04977355742056394,0.14026691637360253,0.7229322596902634,-0.2261689916087236,0.3257161064498515,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05388009060618992,0.09592188488290758,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050242251284243075,0.05334098011546059,0.3469376266316446,-0.05469372650239614,0.1551782290708823,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15791541242211507,0.19107638479628375,0.9086080106242148,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020136082497718914,0.06228406507288804,0.7466796586527886,-0.14266550086991328,0.10239333587447544,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.038463814086873445,0.017791770825300736,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051309093813997494,0.09478420416663245,0.5886530707547482,-0.13515679266623887,0.23777498029423383,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08911929629674564,0.12752350778483051,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05105955372848825,0.06659185400806403,0.44378283381870054,-0.18206354536560346,0.07994443790862696,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.036242321785108264,-0.011836634125008497,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07737637034194596,0.10854287226314552,0.47643948795127167,-0.13615649703410948,0.29090923771800137,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05624771557757225,0.12447028665633297,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004631793129470662,0.08476980580232168,0.9564590135644542,-0.17139667895262906,0.16213309269368775,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05422697716773292,0.04286359146209311,0.995720872088477,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07262254462814684,0.11380868713887038,0.5238495760752578,-0.15126958933115342,0.2965146785874471,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09840946241901262,0.15927090324417087,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04228269233575785,0.0860047207092464,0.6233102065133601,-0.12691160147654776,0.21147698614806346,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04606342745856583,0.09093792809917987,0.9586972329593203,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03849223907827824,0.09380091674116732,0.6818107051708675,-0.14603925798479434,0.2230237361413508,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0616167693144715,0.09663333824999781,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04287576190799811,0.13097794185392186,0.7436125176382162,-0.21479288923362497,0.3005444130496212,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05176812385419897,0.08668457583091918,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014612721775765593,0.06533624731030153,0.8231665264114075,-0.1139211555841099,0.14314659913564107,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04027903226742018,0.051610610239108186,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022323076431218565,0.0702682232695772,0.7509281830518202,-0.11591331705390492,0.16055946991634204,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06575702616659902,0.06259053669083832,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043147288281999555,0.09977146670257152,0.6656921772556545,-0.15312987781017162,0.23942445437417076,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07072405503678529,0.12056817004339553,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003045892369902617,0.06120032718892244,0.9603367758867293,-0.12344330840032913,0.1173515236605239,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.08914524398754384,-0.09873123912294338,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004754367940727429,0.08065666853106836,0.9530314329159594,-0.1634276123955538,0.15391887651409897,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.20307726763446027,0.18215119167713942,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1248353759383276,0.1299602774844445,0.3374825100770047,-0.38050200901731707,0.13083125714066185,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.024512810637070302,-0.06386465323489086,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057960053930853114,0.10719126638180326,0.5890724597768722,-0.15291384309194267,0.26883395095364887,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07633732130063409,0.1631632109309822,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008531958565618232,0.09237639506530186,0.9264681070806474,-0.19026104040100592,0.17319712326976947,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10382956255920585,0.10461557240162149,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12417334172794747,0.14707809720608062,0.39913874054038856,-0.16516862214131112,0.41351530559720606,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.11613348039253325,0.22458001336407568,0.9213036703720862,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03700633511249015,0.10370514166249908,0.721441064506449,-0.24102209219645257,0.16700942197147225,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07969061480682486,0.04817838811905683,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04632174678569739,0.15080880262603422,0.7589211612963237,-0.25035951269135365,0.34300300626274843,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06699064849691959,0.1517393859397447,0.9671401795424975,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018933170452516215,0.10196187513026109,0.8528043530482188,-0.21951945590496474,0.1816531149999323,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0634374101424466,0.04187269891723792,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06254214102532486,0.12844101257137905,0.6266331839394466,-0.19013569153248244,0.31521997358313214,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04499215101620129,0.11337715778016975,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009565114375042753,0.0743540866606296,0.8977196612807992,-0.13670926545968748,0.155839494209773,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0981543148566631,0.08940705598020425,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013318977346400624,0.08765423215938431,0.8793211125861684,-0.1857583014621578,0.15912034676935657,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.03980992732900809,-0.043541165286233655,0.9864402192918322,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02626941009502575,0.12642907685992213,0.835530634847312,-0.22245040668075816,0.2749892268708097,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.052663339045276876,0.057145633265411146,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003317369963850285,0.1303296577420724,0.9797086645826782,-0.25971067282703497,0.2530759328993344,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.02057758779178553,0.0455284327766113,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13280395693930294,0.07465799908321327,0.07619925026413116,-0.2796762138125932,0.014068299933987366,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.053524098446356604,-0.07620288596394251,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004490085307379051,0.09755388015408743,0.9633171330186061,-0.1964046654049178,0.1874244947901597,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.051785860904806115,0.048705517181973586,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11172431711065682,0.10401809047904138,0.28357874569792774,-0.31635572823753244,0.09290709401621881,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03748748433818959,-0.07203497084346579,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006819870251474729,0.09936315873245223,0.9453215977002645,-0.20229378533495052,0.18865404483200104,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15178771396157842,0.14293468539799745,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012572427066703945,0.09622097915116433,0.9895829686365138,-0.18803516453743052,0.19054964995077128,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06749778625907417,0.05017037500091054,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07879802734414695,0.06466933184456598,0.2239241910803713,-0.20601990356818825,0.04842384887989434,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09896553967601776,0.01568082405822953,0.8356888710841501,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06369970632541169,0.08912187328582956,0.4752761009491323,-0.11162686051273368,0.23902627316355707,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08968267114829415,0.15010689802675523,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02353207157803435,0.1058417334308314,0.8241941715947916,-0.18468693310009537,0.2317510762561641,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10201785372422899,0.11646001451561104,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005913128560774649,0.08169548702139483,0.9423437969738444,-0.15480374977159372,0.166630006893143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05538115106859247,0.05493174086336127,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06316041448919685,0.15471869842761368,0.6833747165618482,-0.24121265601372055,0.36753348499211425,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0372923845538869,0.14655949102797539,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017163948221997176,0.06993608298553708,0.8062830738682207,-0.15474693291349448,0.12041903646950011,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07870701121358985,0.042740906929640984,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09199755067101906,0.13720564709603866,0.5030084202508969,-0.17792266273162605,0.36191776407366416,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06575741460144957,0.1571008039073374,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010049346044687227,0.10950223423795051,0.9269347812281166,-0.2254695350758673,0.20537084298649289,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06655915099894358,0.047859945661625644,0.9916453225591361,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04319717819852249,0.0914308169518257,0.6369163699742888,-0.13667169852446404,0.22306605492150905,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07763754941835434,0.11643268929459372,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024934699554938173,0.10839382946295611,0.8182065182322477,-0.188304960760878,0.23817435987075436,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.026385085792732223,0.040627533733511106,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018688885790146527,0.0862361415928893,0.8285640216130337,-0.1883384463908154,0.15096067481052236,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.018853450999595216,0.004936496222277838,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06992255601282388,0.11708428836511413,0.5507894402040319,-0.16041356185473934,0.3002586738803871,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05814555034818394,0.1421871007849227,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07367551129252714,0.11773230873851975,0.5318916129601482,-0.1579354360093995,0.3052864585944538,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03922076519027215,0.07344085649254542,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06975314564511523,0.11636261342575051,0.549291639936244,-0.1591632445526093,0.29866953584283973,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06946694360575675,0.13714784082022596,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043552975689263675,0.10739055837443336,0.6853342798822086,-0.16771298199807969,0.25481893337660705,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.025774452294892163,0.04184807698919794,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034058745513633124,0.08940662251948081,0.7034943463908396,-0.1418279992438627,0.2099454902711289,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0457944132276392,0.09640475361879199,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013479958641007237,0.07410120115336395,0.8557642013285927,-0.15925684503044363,0.13229692774842916,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06737541259984973,0.06238549732906118,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01989190260548445,0.17115102816179037,0.9075463680069547,-0.3565917617095079,0.316807956498539,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.017603878980256716,-0.04052384710881837,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014400160550780257,0.10756260356687239,0.8935824321377157,-0.1972042560560093,0.2260045771575698,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04401463752717093,0.09496060053554031,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03160112523037417,0.12505361702886977,0.8006588383168508,-0.2144127940916078,0.27761504455235614,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0704595151905762,0.1069406681025227,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012495962904131998,0.07497321512968116,0.8677311819609721,-0.13499640825986967,0.15998833406813365,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.044586180609344196,0.05478421142153031,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002834744475516973,0.12355075189011439,0.981709005485999,-0.24022263706865538,0.24589212601968935,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04196731351401767,0.06826755267986839,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034129727243492856,0.11901740191094418,0.7744763487300997,-0.20000934211962185,0.2682687966066076,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07641049579064614,0.10312122035982191,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012722904146065164,0.10253906201531146,0.9901078031223015,-0.20044947605107577,0.20299405688028882,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04729370246240617,0.07734495504314871,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025450695086375996,0.08464819974629434,0.763862119276187,-0.14107495909224974,0.1919763492650017,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0941136543490562,0.11718714435145913,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05258831588332065,0.13929521174256726,0.7060244025702389,-0.22144263018410199,0.32661926195074326,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.059830905272040324,0.1386953049142877,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0604164692310764,0.062218678313720334,0.33225111144907105,-0.18281725435557433,0.06198431589342152,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09318169017182719,0.04385306520037914,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04197355698045369,0.07236423258594517,0.5622938316646013,-0.18433336152002136,0.10038624755911399,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07332336431836976,0.056851913520771076,0.9512976205783472,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048215441932345546,0.13783381585789167,0.7267082878976617,-0.222940547473991,0.3193714313386821,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06649898084958648,0.12020461723968721,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02413158401685335,0.10838690578910253,0.8239528070060179,-0.23735762361396268,0.18909445558025595,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05740022943184874,0.05555825358017411,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02057579397814501,0.06579863244432858,0.7547020531147177,-0.1088677186386775,0.15001930659496754,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.056750903695976185,0.07163850678140123,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06681115369844165,0.10769834450011684,0.535457828291163,-0.14506030163776093,0.27868260903464426,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10144528206027086,0.14504265884334308,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003286615977736298,0.057472556921114026,0.9544321983289994,-0.10977727867438586,0.11635051062985846,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.030552928683960215,0.03815332394026673,0.9946097045025434,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010470872939035696,0.07987033573064042,0.8957783344188635,-0.14665544453582138,0.1675971904138928,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05647818369494686,0.04032793251001892,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09583630647945852,0.06266885793986557,0.12717236268279708,-0.21912271536165492,0.027450102402737875,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.014090167430879418,-0.06041746153754394,0.7267776925673457,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07701962825018668,0.09133319804489091,0.39968913943443496,-0.10265720596762859,0.25669646246800193,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.060384198331904095,0.1206968153447936,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0716718966667956,0.07936316102607037,0.3671461398860135,-0.22780046581724042,0.08445667248364921,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03536050245482643,0.00017553694822498086,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01046414770308158,0.08025933563616662,0.8963468386083009,-0.14742743665207925,0.1683557320582424,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06919419600820144,0.04099004942469297,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09363692468828906,0.06920449490177809,0.17697821663640614,-0.22978067990293516,0.04250683052635705,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.02010214135215789,-0.037985277112655674,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03482777188031991,0.10379151504414141,0.7374222297744846,-0.1693579047521352,0.239013448512775,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.02556633484956902,0.02946121482360326,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04964670724995643,0.08065553707598781,0.538627657348916,-0.1090243113300371,0.20831772582994995,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03737063445327788,0.05088727758389577,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009200255310263559,0.09238307946279575,0.9207325537095938,-0.17254197652321973,0.19094248714374684,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06923315058263049,0.0742504914411913,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053197441695885174,0.114262688773076,0.6418331814051883,-0.17158783493344057,0.27798271832521093,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08041744531204582,0.12431706943268968,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10445221827760726,0.08374841227481203,0.2132141842716913,-0.26920774978664974,0.06030331323143526,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10348111150682447,0.025602944000113502,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07299874370828752,0.14486165377771643,0.6146576783807085,-0.21198288298942453,0.35798037040599956,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06347740917817157,0.13658843236437127,0.9557595790374268,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05035773865952716,0.04631632096441419,0.2777265094938182,-0.1414743326433693,0.04075885532431498,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06258702559660966,0.005583608362658268,0.873574778219852,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008425693143705844,0.09223190884787126,0.9272679409366344,-0.17301914564871648,0.18987053193612816,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06130839590704423,0.08388741371274477,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013235061053024334,0.09460063791244706,0.8888217906600705,-0.17286970149717026,0.19933982360321892,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10267063678508508,0.09818809964748255,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02668039085820362,0.11106545955912427,0.8103089773145141,-0.19181508057729538,0.2451758622937026,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07924641824890989,0.12669436334161469,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010986076806300052,0.09894102882191003,0.9911475339141829,-0.19354486493966178,0.19574208030092177,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03963017674990471,0.03247644073723244,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00823294865041678,0.10734038154684765,0.9389096886528412,-0.2029342977936472,0.21940019509448078,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0757339892153282,0.08184216378981429,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0480299779208789,0.08352304129113783,0.5656537088192531,-0.21234214441327948,0.11628218857152167,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.058798711597882025,0.023167773437662954,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06727887019259657,0.144488947273658,0.6417888996149222,-0.21696954310434644,0.35152728348953954,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08695371796687289,0.15296070822216934,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0030646727848396803,0.11121784888230336,0.9780334674443585,-0.21573058921688867,0.22185993478656804,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08499539427549818,0.10982779680877708,0.9984091646827826,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09745812513980708,0.14299868224689816,0.4960190236121369,-0.18385853817043202,0.37877478845004614,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.025776793643755343,0.11450452889399038,0.9428637474696224,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05566325845787794,0.0934527900201853,0.5518358993912789,-0.23950989712913184,0.128183380213376,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06675623445981352,0.03422327684006761,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0904509624529109,0.12240225313244626,0.4604600517207188,-0.1503470147859455,0.3312489396917673,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06205307810286418,0.1673362922703761,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013387396551393684,0.08990405861028986,0.9881284412672939,-0.17552659496820483,0.17820407427848356,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0907112677394433,0.0847415335049889,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07108890030884772,0.057845965690205545,0.2199827255544769,-0.18488738990493053,0.0427095892872351,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.008944227636383938,-0.059856555052424806,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17722141188079413,0.20361656069948636,0.3847395636333395,-0.2233468349775,0.5777896587390883,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.12331281329916823,0.20797559976800006,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03744430832737215,0.09094395432186803,0.6808082741127099,-0.1414667793558968,0.21635539601064108,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03383368687780608,0.06723531913407763,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09208705440590229,0.13984573132867076,0.5106879183355835,-0.18302691096362952,0.36720101977543407,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09271769895570955,0.20734341984992907,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05416338794728867,0.04810370697652625,0.26100592599176475,-0.14879624838249994,0.040469472487922584,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.0480018658448037,-0.10397456298260205,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01717104236410577,0.08334485881437885,0.8369007542066076,-0.14679059152873108,0.18113267625694263,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05526296723550422,0.056881701913310594,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021755546072669295,0.06987936202903909,0.7557487073931577,-0.1592269454686166,0.115715853323278,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05417710731438022,0.05301662355545656,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07276202087650249,0.11901017850929264,0.5413653596515513,-0.16136283812314292,0.30688687987614793,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.024810217459188884,0.08081589067932567,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028754973511393812,0.0640462325138746,0.6537500678274412,-0.15475104665902428,0.09724109963623667,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07186766589465349,0.06517796935984671,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05862831726052452,0.0932893952589057,0.530145049723741,-0.1248968802035567,0.24215351472460572,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08720868654225462,0.11583524066128557,0.9458960226358858,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004215539077229779,0.08877464689685219,0.9621550889446169,-0.17042794056300897,0.1788590187174685,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08570142664360127,0.079517922741616,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03316154355437182,0.1332258665721544,0.8035854404929048,-0.22892937687791462,0.2952524639866583,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06655794099900551,0.12752507016474646,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012210455454759931,0.11565608076313331,0.9159840477553214,-0.23973690689190208,0.2153159959823822,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03305806132851718,0.026950161606464004,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059039011679867755,0.07109828428594109,0.4069283448044373,-0.08083033388424218,0.19890835724397768,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03973891452348428,0.09180360837936044,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027071617926601982,0.14176159619686315,0.8486712535543466,-0.3059546020283668,0.25181136617516287,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.030466423477274546,0.033246042559986345,0.9827611894425448,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03420479818887189,0.103804800981835,0.7419812785494893,-0.17000701543731056,0.23841661181505436,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07962649499626345,0.12066091346206277,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05792612072539727,0.08876501001229901,0.51448806200921,-0.23255064203563877,0.11669840058484424,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06565777760302749,0.022020062941245158,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032960786850375276,0.11961367575305612,0.7830603455992705,-0.2023513126766992,0.2682728863774497,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1120839588645742,0.160977044318495,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013247740731346797,0.12558209014514515,0.9915896697910755,-0.24572879324688313,0.2483783413931525,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.045877193678091725,-0.01994896818344703,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06257722770211338,0.126715532727492,0.6217515748138327,-0.3118605798027282,0.18670612439850143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.004285396863299831,-0.05904524641028335,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017920289452642155,0.13112168880661923,0.8913766788231026,-0.24003115040044623,0.27587172930573056,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.028858052019112186,0.07579735657510553,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055916982120147785,0.13119827962120928,0.6702418611111123,-0.20218513235498697,0.31401909659528254,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03236124816650382,0.09818123725444147,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09143703852347465,0.08084966449547878,0.2589068715709222,-0.2504899576710128,0.06761588062406351,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.03943536035479484,-0.09846361533632528,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0509018813790368,0.16306224328158844,0.7551167637094246,-0.2698851739356211,0.3716889366936947,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.49485844269613577,0.5309110585623947,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05676695589690646,0.09800774612119845,0.5628482499409688,-0.1360404999771887,0.24957441177100165,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07736021338001679,0.13863934853406112,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054360789607040605,0.09436565606336744,0.564968448311524,-0.13128170078313914,0.24000327999722035,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07882105893407408,0.1275843195766872,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04675648245459778,0.07588609972163005,0.5382319110148958,-0.19604474182791165,0.10253177691871611,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.025363848585414676,-0.016586535057442408,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0252453537560213,0.09032461566875857,0.7800415757189939,-0.15244732910970543,0.20293803662174803,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08097798699906561,0.10042201977103118,0.9709847934855533,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05572326399910714,0.07358935678760883,0.44946557141277343,-0.20049321559134192,0.08904668759312766,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.029912610322173593,-0.025993987979222397,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04608675369530983,0.07589924351266887,0.5441344698836252,-0.19540087042185378,0.1032273630312341,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.031122666730645655,-0.012432176023235122,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031318218307084596,0.11041384366066047,0.7768633060451876,-0.1858953503343786,0.24853178694854777,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04005662126779167,0.08561121153923036,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0849906170260361,0.10700805202975396,0.42763056044730086,-0.12552284835236127,0.29550408240443343,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.043137464807391314,0.08617918444228138,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049493594789245345,0.09309643721008876,0.5953388795320289,-0.13365200257223972,0.2326391921507304,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10541322340158779,0.15372826207313717,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.074572327067463,0.09021155873179541,0.40904672857805047,-0.25204259669293594,0.10289794255800996,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.015781512476466305,-0.051777637283178926,0.9256023179739352,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04981149450535626,0.15399476358378816,0.7465525798438581,-0.3527603915017837,0.25313740249107114,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07105720636986164,0.053739288264920596,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0523724248906565,0.09872419281660692,0.5961318104066496,-0.24658932308005896,0.14184447329874597,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05775236815582388,0.014691377094340331,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0026477513738547426,0.11852769304709448,0.982191466608525,-0.2358234323937553,0.23052792964604585,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03449228571289703,0.018710496963377017,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03991670900494048,0.12695434099066358,0.7534048364367003,-0.20983644283585898,0.2896698608457399,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.047743131035710616,0.1089213593898952,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061418831168630256,0.07403170596297383,0.40735579748411355,-0.08422133958979838,0.2070590019270589,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09435025788863396,0.1477404185154737,0.9241469906913099,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1834161681534874,0.08947233219884188,0.04116632381266905,-0.3594321814290883,-0.007400154877886506,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.01978142550959106,-0.17390340235610433,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031390065570198064,0.15751448906981896,0.8421650892675261,-0.3412632042025632,0.278483073062167,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04972775741174661,0.021380117461148915,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0763298796652578,0.1109711535656159,0.49204558792889896,-0.1419800666520578,0.2946398259825734,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06861794944485934,0.11647395344026405,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0021461251695576557,0.08047385718812237,0.978740374533183,-0.15616748046759044,0.16045973080670572,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.11722533527903732,0.10221062817085007,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07090428560391532,0.11967182320422609,0.5539336548149509,-0.16452220551534802,0.30633077672317865,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.062353944072080746,0.07057226876165305,0.9488833301512906,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014917464270737119,0.08416010273610236,0.8594212958704753,-0.18048290105350018,0.15064797251202594,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15642808654824683,0.1356042988937145,0.9839789607467108,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046391797739697996,0.11154613480045235,0.6777583947038146,-0.17304929048682005,0.265832885966216,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04240326669354933,0.017713157373700168,0.9620942694833536,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030705100363190255,0.08715553327168887,0.7248391583656799,-0.14075314962741675,0.20216335035379723,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1047086043437641,0.11898320888995939,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04642847913160564,0.10997708790810459,0.6731828518279022,-0.16992587410269433,0.2627828323659056,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.065349546597261,0.060080638804905516,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062322117454507144,0.09679436580851668,0.5201182781488274,-0.12809829473830003,0.2527425296473143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0675143026743745,0.11405979350196876,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01557945287772921,0.06999041040427187,0.8239908182002916,-0.12211040838021323,0.15326931413567166,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.057257034580680995,0.051318468580546533,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07767640752211967,0.11672710907198403,0.5062313158858422,-0.15195704312244507,0.3073098581666844,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05251030797179643,0.10695450526369352,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05097531759868877,0.04848062672448984,0.29382729735842184,-0.04439904481518951,0.14634968001256704,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06473224289998294,0.09432287235111678,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0010918489183871852,0.08594958973014619,0.989872225152874,-0.17017768534603855,0.1679939875092642,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07369719785956642,0.06280871115262696,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14103138082719574,0.1639284534862567,0.39024339977381806,-0.18145974169055584,0.4635225033449473,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06745825364854359,0.10970661668440468,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013876418906313023,0.06982722554275417,0.8426017039557105,-0.12349241407344122,0.15124525188606727,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.11355752105114755,0.11784451145671704,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013406476140421536,0.0863866072485526,0.8767663103491643,-0.18335204293869234,0.15653909065784927,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03586572061082813,0.01001923629298648,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038936309152046454,0.08261436535222791,0.6377403840837892,-0.12358824867747792,0.20146086698157084,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0941235260229319,0.11762192328793551,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010560130518937269,0.05386143149445676,0.8446845137729184,-0.09539971436251632,0.11651997540039086,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06187269317439689,0.05026871051440748,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015367730401659278,0.0994424674554742,0.8772804650076893,-0.1802622061568495,0.21099766696016808,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05903697675598961,0.06283178887503899,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015495506556830952,0.08302728491687525,0.8520656554216919,-0.14784137452152968,0.1788323876351916,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.024550211184570174,0.02869839363272792,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02889458627948706,0.08366189548854973,0.7300364787663556,-0.13569074356581134,0.1934799161247855,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15456931347526115,0.19314851836763577,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05370359419530141,0.08103602149579721,0.5079828921383716,-0.21312312741711173,0.10571593902650891,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.012355002807083655,-0.0652819675667755,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0549683087961736,0.04546534014596129,0.22789820745071343,-0.03461349547612085,0.14455011306846804,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05126592895060643,0.09293721146763649,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06781757074345096,0.04729038520444155,0.1529113484715718,-0.02536017779522373,0.16099531928212565,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08054859278882454,0.09393565461572828,0.769695804798565,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018833279290508622,0.030454091817342304,0.5369134831842963,-0.04117138544340261,0.07883794402441986,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11253448993992496,0.1131869562180604,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042190928951942076,0.05547500431341542,0.4477111550963032,-0.06711323466928881,0.15149509257317298,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.033690908523249234,-0.05611506180234521,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03993850297839738,0.03399873527027597,0.24132729591554375,-0.02705028537575649,0.10692729133255124,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.017119733464298875,0.018361451467432503,0.8487082760058587,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0492775642948383,0.033945683268663346,0.14795903203692085,-0.017606694014902433,0.11616182260457904,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.13595359666124474,0.21225501001758515,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05154323376463628,0.04431330658733331,0.24597204743215886,-0.03576868218321563,0.1388551497124882,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02790150611702262,0.023201631845236204,0.8552269457897888,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0009486895567885124,0.030156653193329098,0.9749309981627781,-0.05846992240563063,0.060367301519207654,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11752313363811577,0.1049173734022963,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016928430949927697,0.02603004107580987,0.5161203672197616,-0.03435938604136608,0.06821624794122147,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.027915262044266927,-0.0009458807045465339,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045404279282892465,0.04680143624628234,0.3329922603465125,-0.046810077588011936,0.13761863615379688,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02979387502467823,-0.0565852825476873,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01799103181951163,0.02979906624293995,0.5466082964141086,-0.04072301521284764,0.07670507885187089,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02561484356049953,0.03455702567222856,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05952649978512803,0.0524778562052943,0.2578426322478634,-0.04387228768946397,0.16292528725972003,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.08406168423358708,-0.059005375520059675,0.8664830381179188,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007347615236633569,0.03332459889311951,0.8256880842106118,-0.05831290079408915,0.07300813126735628,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.033992962111868086,0.008549255732158733,0.980597249022118,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014024544581739963,0.024934896649025415,0.5743596364326029,-0.03510547454913654,0.06315456371261646,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.016541175431126414,0.004826914762999854,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09864677107990456,0.07159660547331725,0.16959993967668385,-0.04242229554273082,0.23971583770253996,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05065656087375026,0.28359838470897614,0.7842677313995,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10548251937768299,0.06566087694340038,0.10954170596598059,-0.023891192724928595,0.23485623148029458,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.3203177028801584,0.48337036443414677,0.6985162532376802,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0117769367780903,0.02256188631751146,0.6021840155881482,-0.05623133825447755,0.032677464698296944,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.009974904760311558,-0.03637834562203696,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011819921274627273,0.03380363516668025,0.7269106731451191,-0.05478445514644291,0.07842429769569746,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.045364217504471,0.019534907147136335,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007107410662185223,0.02706029224186622,0.7930547598273069,-0.046210342936041905,0.060425164260412355,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.006575962942787717,-0.01764556192494319,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004378324586011995,0.028377518255851334,0.8775175666403368,-0.051534801280152975,0.06029145045217696,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04623598049676403,0.015427920771057467,0.9858833377512005,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05268102848245911,0.04375348870837733,0.22981108361250774,-0.03352786051123901,0.13888991747615723,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.009902913497955067,0.02321750616725202,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050918285957045145,0.044507503340051775,0.25379702095159096,-0.03677626202295457,0.13861283393704488,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09642081688025353,0.08920748491164349,0.8634493629908433,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013771910947493799,0.0334931193411421,0.6813188178950602,-0.07976446817140179,0.052220646276414186,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.13208642128880166,0.08502410458501737,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0780615531325062,0.06459763143775361,0.2281238184576603,-0.04921721256753883,0.20534031883255124,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.012030320225477623,0.05013861048940525,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007868085969353974,0.0296594062508474,0.7910303748307811,-0.06630695648183811,0.05057078454313016,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08269812062843858,0.011092650930619018,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026752011702373624,0.028308886304315425,0.34564849461240155,-0.02902588644901835,0.0825299098537656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.027855005400581313,0.06613369889645863,0.9073272983575541,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00734754799026055,0.02847466899724465,0.7966082837157833,-0.04875699706846879,0.06345209304898988,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10351182939738054,0.06324283932048719,0.9738068609884574,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0357605810069908,0.027795208845968932,0.199536437293406,-0.019005202127006474,0.09052636414098808,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.016746220317831184,0.08636831164162455,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01232543721200155,0.02831954443980355,0.6638056170051025,-0.04347346100238653,0.06812433542638963,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.048114319374855996,0.014018824937954295,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036391543346368536,0.030331369647291547,0.2314518956499342,-0.02337131799660657,0.09615440468934364,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017557424273252055,0.009112442463281535,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0029173410093427006,0.02599522935271794,0.9107420851332975,-0.04830188533786063,0.05413656735654604,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.013668007808735462,-0.032344968895243235,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04743388793936592,0.041904602744934294,0.2588344926389012,-0.03513208229540019,0.12999985817413204,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07451862631913875,0.041665242860165534,0.8664830381179188,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06407614870793468,0.052262705861781035,0.22143756541055165,-0.03889872120880232,0.1670510186246717,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.022237507867751374,0.041566167760676835,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000957568280886078,0.02882980299992574,0.9735323192869297,-0.05584670858709576,0.05776184514886792,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0393249083128056,-0.011425329098106824,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018453106652479352,0.04004236383310357,0.645349143767086,-0.060443635084879606,0.09734984838983832,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.018345155422753775,-0.02725426194133001,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038177619650344795,0.02756634484544844,0.16741395262449854,-0.09249246477235797,0.016137225471668376,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.14235898656022508,0.02008626927019633,0.7842677313995,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001447101372689923,0.03350251546731229,0.9655845122655885,-0.06456396933715687,0.06745817208253672,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.037849837078625784,0.043293308886111666,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03220761700478249,0.02490639811115633,0.19725780273211677,-0.08128148456100368,0.016866250551438706,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08832993048015671,0.014653743413085438,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024034191349055257,0.02849095116306932,0.39978464724498397,-0.03210243497833615,0.08017081767644665,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.013602513922006454,0.030417885966993075,0.921525791075194,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018286079972501056,0.02346671202043565,0.4366424116838107,-0.027951128335632645,0.06452328828063475,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.018575716346097018,0.028903285049968527,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03393046398795613,0.03011400742553376,0.2610293037379937,-0.025404121663180193,0.09326504963909245,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04070471405044266,0.05742343373441309,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015530110875477487,0.028766375163417242,0.5898088086819143,-0.041149192110921634,0.07220941386187661,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.012336870831899797,-0.014429834998704419,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017161967920389973,0.024731829124515863,0.48843118484818326,-0.03156794081482527,0.06589187665560522,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.028857187137978312,0.01397220616131504,0.9404802865694325,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007853447527683913,0.023647439641226568,0.740111961940087,-0.03873985415400233,0.05444674920937016,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.013236091591079354,-0.016565162032086418,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006848025801289067,0.01886235890308898,0.7168991297797163,-0.04401313086694174,0.030317079264363608,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.014999378346477823,-0.03317497798073978,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012394256123922478,0.022687020062988745,0.5853790763062896,-0.05709521259493239,0.032306700347087436,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.03701055726011266,0.009424198361421336,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010841289977208063,0.02516116610880646,0.6669635800132846,-0.060417135014012684,0.03873455505959656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.021601017159556757,-0.022369173837208538,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022979582616925162,0.02163586319523645,0.28930144605981045,-0.0196502460788573,0.06560941131270762,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.00595926192788981,0.014388865235406473,0.8780447660402404,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012360959767646767,0.02220268869813187,0.5782514676244328,-0.03138570322639252,0.05610762276168604,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017877022579193862,0.003047604625413624,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032009426633257225,0.02511059037681942,0.20368823947587666,-0.017466767431856746,0.0814856206983712,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02792490199185313,0.03634809433409313,0.8179445630780711,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12220070171725991,0.040048488777899065,0.002545942811590354,-0.20110951162795898,-0.04329189180656083,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.4265201841445645,0.005181005361375644,0.07655187135759178,0.7315829080671686 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0869136503674201,0.036886804051787125,0.019301775792396753,0.01423440832965428,0.15959289240518593,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07964087899606268,0.1695617976612132,0.3170765275914746,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047925031332528734,0.05055112769590075,0.3440986802537802,-0.05167746174153243,0.1475275244065899,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05328967965006322,0.12281086338194562,0.9053547642872083,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026238056159205377,0.03145192909366513,0.40501853391094444,-0.03573267906480185,0.0882087913832126,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06285263642607242,0.07418102844592275,0.9237532919369174,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025358468288172762,0.02889362946543486,0.3810500119406752,-0.03157156789277747,0.082288504469123,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03389751967882046,0.013215652490714923,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033112786204904272,0.03750163919746383,0.9297175313559418,-0.07057939264012773,0.07720194988110858,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.027266464143950436,-0.09493128664672716,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05202752925934285,0.035326336172632256,0.1421804919818045,-0.017577073334950753,0.12163213185363644,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02688984661146658,0.09392905933798888,0.7607934302264618,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015309885000156516,0.044212920091308935,0.7294516633987557,-0.10242400624528394,0.07180423624497093,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.015834903883347684,-0.11229857423658761,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042320787539941396,0.03463446178541677,0.22298604828833057,-0.025920592966107103,0.1105621680459899,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.026015416208646933,0.025779217340288593,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021743473372910112,0.027131341345227288,0.4237183906377324,-0.07520121727695217,0.03171427053113195,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0036212208086452346,-0.07667292785277323,0.9288749656602147,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00924528437713622,0.025473221492196437,0.7169820477600121,-0.040945413296582855,0.05943598205085529,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.055800529439733536,0.08585032218818286,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048352239789502614,0.032323753457977694,0.13605754793052996,-0.015336278680224004,0.11204075825922924,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.013186585703059169,0.007852201105101196,0.7473242853882033,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04966233272473593,0.03432428011859669,0.1492984046370996,-0.01796788698768989,0.11729255243716175,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.03667124208973999,0.04633040422604163,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011024477810514632,0.03990869392807264,0.7826098690425594,-0.06760888986583138,0.08965784548686065,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11819732439872763,0.012016061603057963,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06820008549230419,0.03650076140241872,0.06296984707730265,-0.00371852444757223,0.1401186954321806,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10672243232379518,0.1403471760612893,0.5817074626033015,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010520255573386431,0.031226845754607845,0.7365011551225369,-0.05100699079604164,0.07204750194281449,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.12078589545378823,0.07057721730013451,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04939136326330818,0.035104201363707684,0.1607793293319946,-0.019775560059011203,0.11855828658562756,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05378652708703109,0.049636515482108394,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018138778423621472,0.033331571139726936,0.586836436111634,-0.047535475246122956,0.08381303209336591,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.077382307628409,0.13955561416756035,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01453822003277429,0.029230379682962944,0.6194055567293767,-0.043055325801428436,0.07213176586697702,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11740643533855058,0.07456951384799537,0.9576211468940484,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03070955524289286,0.030711160574977196,0.31838665246183995,-0.02980162023210246,0.09122073071788818,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1361665512327761,0.1561342894870795,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008951291143556812,0.02039482849754768,0.6611459826209107,-0.031233287455634057,0.04913586974274768,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.056454206330853435,-0.06905070772688421,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029436468127781477,0.024045869861047866,0.2221368817405739,-0.07681480953101415,0.01794187327545119,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017686297773271433,-0.07822413032995129,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011141209247678733,0.022098263364958487,0.6146268274029908,-0.032399701194474315,0.054682119689831776,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05409868288796307,0.006766435463054423,0.9557595790374268,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023756939572392277,0.05627789587050768,0.6733198986662638,-0.08712918679427088,0.13464306593905545,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.01240262171936701,-0.00271839151614083,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0035533763640868523,0.028007465808474127,0.8991521821461463,-0.058737376135406735,0.051630623407233026,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.15666984893104965,0.1213280128310128,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03726694720372416,0.04386503815710003,0.39644097481460994,-0.04916173121308348,0.1236956256205318,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.09605592747818545,-0.06564321411189347,0.9212557438608796,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022319711696272778,0.02302512307687739,0.3333821612038357,-0.02304741988564161,0.06768684327818716,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0020340570753792104,0.005117635649591896,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019425915614087595,0.025536497334812273,0.4476083652660461,-0.06974128769099333,0.03088945646281814,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07470805518305289,-0.10050235537547224,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0041589471608474175,0.027206665525517235,0.8786387527340637,-0.05776510469061057,0.049447210368915744,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.027650460244181725,-0.03422834988982452,0.986191362849829,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009033594551929456,0.022152192297577086,0.6838021509162477,-0.03461357377966076,0.05268076288351968,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.005324683172916868,-0.032577753875234094,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005308806015158551,0.027500639419484108,0.8470956471735864,-0.0488765776184006,0.059494189648717694,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03515592636546657,-0.05747146098988928,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005164418852057205,0.017429079386286385,0.7672603644767021,-0.03950548774577101,0.0291766500416566,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.011599208472595067,-0.04265058448634044,0.9686101294099047,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014893065873547383,0.024767344682970125,0.9521028282662771,-0.050289192755837986,0.04731057958112851,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.009758863595189293,-0.03498997182314113,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02144239714532661,0.020470256560776626,0.29597297517131327,-0.06177559405409398,0.018890799763440765,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.014260470958433,-0.06853843188509401,0.8833721946393759,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0031514832757183918,0.025795436553353455,0.9028693815211306,-0.04767408497082576,0.05397705152226254,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04775993781295779,0.02448963749844422,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015562524159948809,0.024988236500444797,0.5340368980733734,-0.06479764049485863,0.033672592174961005,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.005882817507713343,-0.026917797476136922,0.9464658142652354,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02768506446348029,0.03654955321821333,0.4495457132504401,-0.04432968154133196,0.09969981046829254,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04319596700714968,-0.07933653509153034,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02031177453301997,0.03462257655818685,0.5580056196273389,-0.04790618813218485,0.08852973719822478,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06340348152902431,0.025708936100854816,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016660930164621,0.02951060524212815,0.572913513571472,-0.04148475299248838,0.07480661332173039,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.010771193995502793,-0.01816514269631215,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014353930911273259,0.026212637633702143,0.5845004501435989,-0.03729366187972612,0.06600152370227264,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05182621027344743,0.09821252034461168,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016436388808126177,0.03362140627022494,0.625401838588032,-0.04980893622824947,0.08268171384450182,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.00751624946601316,-0.041458465129667894,0.9596829295789286,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004444380273506782,0.023335790219642445,0.8491218612188612,-0.04153486865070982,0.05042362919772339,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.0118984347851077,-0.030757219569006254,0.9828627793326524,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018384623120566927,0.029839058686988502,0.5384205737555187,-0.04040822229499209,0.07717746853612595,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.009303920012706274,0.016322539363258233,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003323216611639487,0.02620579431575439,0.8991997660147979,-0.05495732579585179,0.04831089257257282,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.028503421131978544,0.0011698866027879228,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01478785627970726,0.0345911284460952,0.6694120213708978,-0.05336814317103389,0.08294385573044841,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.024042354467473753,-0.04958842862414022,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027433188870099306,0.027314263230156864,0.31626349013405125,-0.08125134957604527,0.02638497183584666,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09942026549733227,0.0901626396299068,0.9025176929330414,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02824666690264156,0.02703608986455282,0.29722316339280197,-0.025023399982576213,0.08151673378785933,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0858871954831661,0.1517192548662831,0.8843360296870468,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01999548730988347,0.02958013104598117,0.49973439834385447,-0.038287184747619926,0.07827815936738687,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017694464102195735,-0.042991496603767346,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020585734489131934,0.02665465271121883,0.44072193605169896,-0.03193277465336472,0.07310424363162858,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.01046351118796273,-0.01849594770513646,0.9320838159679753,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012882633928841166,0.02598801895094721,0.6205692826135774,-0.06408765339233756,0.03832238553465523,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09558197806571071,0.0468142505196049,0.9580596405456464,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0063474344606186004,0.023978254332111783,0.7914651016625055,-0.05359255083882178,0.04089768191758458,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03238352033980098,-0.04380121840981913,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04651741899518313,0.024360573106254557,0.05743711060965288,-0.0014809922112326984,0.09451583020159895,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04538794211986861,0.019963242385632976,0.5608066224101164,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002581570658598894,0.02878649244338922,0.928619608657574,-0.054137370043720864,0.059300511360918656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08529961245113053,0.024906500817467935,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07617231994942326,0.04265374004285677,0.07544424867359956,-0.00786969930598408,0.1602143392048306,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1447394070671882,0.2611686264228228,0.6286648421036044,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01227915165857129,0.027451019204523926,0.6550712595265549,-0.04180846368885513,0.06636676700599771,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07462460307732918,0.016448957031327933,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05751121109829769,0.03921181946524192,0.14382893166460414,-0.019749082681949755,0.13477150487854514,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1604243798468195,0.24492771421077159,0.7626680424539931,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005708113715584691,0.02790300159337337,0.8380891009144288,-0.06068628432472143,0.04927005689355205,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0940663235565737,0.014625282030312305,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06909027404541818,0.04098209057905958,0.09317786282608247,-0.011658041157693227,0.14983858924852958,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.19749904903542537,0.27338240173236167,0.6699741992153797,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008680338500729842,0.02118023887265711,0.6823106844338145,-0.05041243611705782,0.033051759115598135,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02496186193732358,-0.01649387805407424,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013649257882203666,0.020543916899295148,0.5071036194950174,-0.054127590096384195,0.026829074331976868,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06293374680829279,-0.005227032441497958,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016248008365698806,0.02115401767348889,0.44322666695778845,-0.05792844152017229,0.02543242478877468,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.030557466792859037,-0.0015820938333291094,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004895508720984525,0.02467772953291687,0.8429248770387063,-0.04372780586998208,0.053518823311951125,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.012640289765509391,-0.02294808134412334,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057372861633468414,0.03943422896677956,0.14706033819095773,-0.020325652654336654,0.1350713759212735,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.018329069071741064,0.06286133038323838,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034200655006096155,0.03404895995621537,0.316214823376119,-0.10128840265475911,0.032887092642566805,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.062258477306679695,-0.03303357375104121,0.9025176929330414,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0050962620551213405,0.01986534077492783,0.7977629288201368,-0.044237574170875864,0.03404505006063318,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09172296807746215,0.06209132646604154,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023362917147256496,0.027752518635384936,0.4007572766234482,-0.03131875210841938,0.07804458640293238,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.004804686848662507,0.001821041149213321,0.922090220822299,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005928416770949665,0.024164413608939016,0.8064145267028009,-0.04168349514527591,0.05354032868717524,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09717671293580564,0.039176212626735624,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03649448971406888,0.029503490981783093,0.21736528516728215,-0.021637175989839295,0.09462615541797706,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.009810574076775895,0.007096367827855249,0.8311395152494632,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009612738053548528,0.029034882144035577,0.7408888913314257,-0.047595612768108746,0.0668210888752058,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07971982258661217,0.01799734945735991,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02649543954057298,0.029563505330680574,0.37107169788652816,-0.031754474341820244,0.08474535342296621,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.009795630107326632,-0.005129723674087124,0.915340937794674,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05259971373657159,0.03457467145189227,0.12954897312092156,-0.015523859975598936,0.12072328744874211,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06551789737340802,0.1576742118341338,0.7324499634144411,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014613342234676124,0.042970117949289975,0.7341055302390338,-0.07005204646213846,0.09927873093149071,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.022765572254972603,-0.043837022067301994,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01828244704603815,0.03233482219344053,0.5723457366267393,-0.04542788050486085,0.08199277459693716,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10542633085607116,0.06907640482296484,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059314019806243554,0.06406297928112865,0.35548376301963824,-0.06691130376195391,0.185539343374441,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02103622046644876,-0.0016622871261566382,0.9108386596575023,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06372626198948894,0.03798560929638432,0.0947753089328684,-0.011117990934346789,0.13857051491332467,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08038487771082885,0.10970697676910471,0.6729775750805861,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0020833888430823854,0.03991270316456873,0.9584157230277843,-0.0807246560454832,0.07655787835931843,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.00736426523487737,-0.04998627564409998,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011635306182828476,0.026790493382587103,0.6644724740192329,-0.06442146651622489,0.04115085415056795,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09410754144832988,0.03540061562842421,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008069624393740836,0.031621519898112814,0.7988012614013966,-0.054235260980724745,0.07037450976820642,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1361715678729157,0.14097341026294463,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005209563079519402,0.021285684706039875,0.8068721593112554,-0.04714942397172078,0.036730297812681986,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04255311857745075,-0.09281590671672345,0.9742852449973755,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02808383277284448,0.032305831891521856,0.3855830105570405,-0.09173703981075632,0.035569374265067365,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1662524136806432,0.026423366359041665,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037911783622351126,0.053376400520198576,0.47825477713393083,-0.06725743426559141,0.14308100151029368,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02385208676015465,-0.028446009923389543,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007556223239584768,0.024239059628630995,0.7555224430061782,-0.05531521258015788,0.040202766100988344,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08194374290603296,0.05694423777997381,0.9654221498691481,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015683608711135385,0.020749759944530707,0.45051535403655985,-0.02520030259538023,0.056567520017651,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.0003887701084415337,0.0016604228320889747,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01592540355592322,0.026524847524882062,0.5488337011918631,-0.06818815341544479,0.03633734630359835,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.037940712333135375,-0.013188498589657227,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008580068716671652,0.02294046550971507,0.7087380211463703,-0.03662025937081474,0.053780396804158054,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,3.7385985133505515e-05,-0.019063589481754694,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033238194613805696,0.027349541908130586,0.9033765070265289,-0.05056385194469611,0.057211490867457256,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04623845723949467,0.024806759787276565,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019057375775248537,0.021386312884879917,0.3738059376855196,-0.06119550756550515,0.023080756015008076,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.006766348679736066,-0.01163778635636299,0.915824547329523,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00292144686585934,0.02325519012654875,0.9001380491499873,-0.048741886865724594,0.04289899313400592,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.0007938805130454892,-0.019501033405402452,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027231089912925464,0.03826080910688649,0.47735770312315184,-0.048155397941541646,0.10261757776739258,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.023587540243789187,-0.012725736315501484,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0580420689872432,0.03218398533664463,0.07262687250940264,-0.00537105991213007,0.12145519788661646,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.013285477529620376,0.03092543193056962,0.6232563394374466,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0035871736364184144,0.022075715310280127,0.8710594389595734,-0.039909309657176345,0.04708365693001318,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06924229457969518,0.04355940768191363,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042515766098632016,0.040908168644182834,0.2997576159159825,-0.038086898367449856,0.12311843056471389,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0829630509548442,0.02918997159540242,0.8872020712681092,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012787227489470789,0.027526113039892,0.6426939249802754,-0.041448347627758356,0.06702280260669993,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04817240554911532,0.026387810284759457,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.064344712904479,0.03443107947849508,0.06292216959019625,-0.0034959369801199347,0.13218536278907794,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06846676091797184,0.14990812855683935,0.5817074626033015,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017374820054213095,0.029798033607981608,0.5604065906658642,-0.04133719234467756,0.07608683245310376,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.008054726625344389,-0.00910779008807582,0.9509421797147564,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006976281660967065,0.04304727264503329,0.8714001416699111,-0.07784112738432786,0.09179369070626198,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.24367566993648612,0.14788197261473354,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00968852010437142,0.03991125016427523,0.8084141665687453,-0.06894988420538455,0.08832692441412739,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.16891410422435868,0.07953355587496935,0.974516576191754,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023691595449805272,0.03593588090612986,0.5103793060344342,-0.04711401250013046,0.094497203399741,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07366136607307451,0.02716618576903221,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009166412595775667,0.04067800098015335,0.8219142674646107,-0.07098274520868868,0.08931557040024,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02179535399170427,-0.045925467841161124,0.9793038292216457,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01297003961608401,0.03131772360610547,0.6791547837960341,-0.07467634550380471,0.0487362662716367,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1414971888837611,0.06149428221603626,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06370697422068372,0.07735737673752141,0.41105350141080055,-0.08871272306237654,0.21612667150374398,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.3276727251283103,0.11286544708301069,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006311599613447861,0.027591479334081535,0.8192651211600015,-0.06067596801701981,0.04805276879012409,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.015117657297099182,-0.06394607416944462,0.9784383200536336,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011182573516285026,0.026383943741127267,0.6720785409441608,-0.06316769617370001,0.04080254914112995,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.015339907675015071,-0.06547763480869272,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027923628641601264,0.03401116465639602,0.4124886759744587,-0.03908964972694723,0.09493690701014976,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.17584262541385354,0.15788704794229227,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007087472267727103,0.024717746238742993,0.7745724614511642,-0.055789633045644674,0.04161468851019047,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.037470671744266826,-0.027575694816707005,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03576110772478624,0.03237208590694503,0.2704483983780293,-0.028022641704820862,0.09954485715439335,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0995947231648087,0.10027166501076243,0.870012817074135,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030477586508376325,0.03382494145724385,0.36851017924241936,-0.03616877037396192,0.09712394339071458,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.14519201192698494,0.13528050734384478,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047222309333192644,0.02309173324968266,0.04199455736799574,-0.09272068505500852,-0.0017239336113767656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.012285113302457495,-0.09400893122878069,0.4909466809825482,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02868653976690297,0.025585179638387714,0.2633647501763094,-0.07909783213333957,0.021724752599533624,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.005645728017443351,-0.07172206795300469,0.8670850705749964,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049020177444194186,0.027560543362750663,0.07662030039938779,-0.005283236832127454,0.10332359172051583,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.034736365840893915,0.005772097036385324,0.6296189902384475,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02482685185640218,0.03479458702246619,0.47624354633733046,-0.04373002849190781,0.09338373220471217,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.127722747349198,0.13791152778428284,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047046096123078696,0.04556780467788655,0.3029496974938146,-0.04273759727210173,0.13682978951825914,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.052854813674651835,0.04341858458041458,0.8910021114138201,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037928216747156844,0.03472306554490514,0.2758413980267583,-0.030487742561443106,0.1063441760557568,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.12876548334049465,0.127573195077167,0.8716406527156833,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008757521345904361,0.04147444764509478,0.8329535874757512,-0.07296090062821213,0.09047594332002086,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1622751059765691,0.06272416851792383,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025906541420579975,0.04158276389296058,0.5338942030736158,-0.05602529949826833,0.10783838233942829,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10766191219137917,0.061045001149995254,0.9464658142652354,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008457619155250663,0.02895582803358963,0.7704834472231746,-0.04859496884078705,0.06551020715128839,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.012517021380513063,9.140941070013568e-05,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05636747518795784,0.05672181384611529,0.3213874331221241,-0.055393316870772445,0.1681282672466881,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1802006348523323,0.2407501938984257,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0304814646815507,0.037947275620005806,0.42265477050136735,-0.04428725818173003,0.10525018754483144,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04450455635247246,-0.04267048323342717,0.9288749656602147,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02076245548597575,0.019794948136993316,0.2953358671572245,-0.05976507075060333,0.018240159778651833,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017444349036563316,-0.027286743257804294,0.8830041858734644,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030634241453177006,0.0277946387282056,0.27154249494692906,-0.024130418359676675,0.08539890126603068,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.10544725421049515,-2.7099356703262806e-05,0.870012817074135,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03442082960365617,0.023710003259331085,0.1479357674876096,-0.08113740236994471,0.012295743162632385,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1168941735258386,0.02086117689409045,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042085609905837894,0.03381288618167421,0.21452283890917737,-0.024536994084009923,0.10870821389568572,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.14307812511658294,0.0186237537922721,0.8289622204693651,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04138901913225279,0.02892282381887197,0.153782965223911,-0.09837657787538034,0.015598539610874769,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.12462089739430492,0.029409832435672596,0.7711789647234355,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00933712333090499,0.024095628322627585,0.6987423683090546,-0.038139258750167424,0.05681350541197741,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07699003793460557,-0.019753508769120378,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02665318889409243,0.020718671897979466,0.19958528471061832,-0.06747584643471911,0.014169468646534258,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0845596811129878,0.012634002801494282,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010330699290762068,0.023627192898680382,0.6623492329059426,-0.03622270959078013,0.056884108172304264,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.05381181943671176,-0.03840320411253018,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007501650801358226,0.021087120165658484,0.9716524466653712,-0.04079845778910657,0.04229878794937822,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05340819656309137,0.034317870096177795,0.9975397208522654,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011322261120709816,0.025326980535830924,0.6552643575696184,-0.06122481559154795,0.03858029335012832,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.057041196718226085,-0.08285146836489515,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006182104443192023,0.01880336903307956,0.74262384060413,-0.04323097989366384,0.030866771007279793,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.03646028621186311,0.015018819403336535,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01789751691216576,0.02146703771308721,0.40530330880632126,-0.024399669571999762,0.060194703396331276,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07908338815902588,-0.030276035984242267,0.9237532919369174,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03213784506888045,0.0299302701045479,0.28405671179676334,-0.09111040723854211,0.026834717100781204,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.13494486486214013,-0.03672487438778231,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007326795910335946,0.03198576934055617,0.8190225414381336,-0.07034937353464499,0.0556957817139731,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03368477723589157,0.00812029437508787,0.9783899072890752,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005335352731613258,0.022403377461553332,0.8119771874338766,-0.038806733709534386,0.0494774391727609,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.022715797000319126,0.024252372565007983,0.9761434066106486,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010576267478718993,0.02851663962822729,0.9704469645375244,-0.05512961437862689,0.05724486787437069,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.08813519219231597,-0.037419099226833286,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00309381016554092,0.025632271961421323,0.9040341902035539,-0.047410269701246066,0.05359789003232791,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06180352140911186,0.0612751866463044,0.9884605236688444,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014100599096465001,0.02511432015266528,0.575033003608399,-0.06358414205743526,0.03538294386450525,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.021427290982532488,-0.020006467484949577,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02362525093124244,0.022427011765895368,0.293250103028926,-0.06781390479317442,0.020563402930689544,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.007768333231592063,-0.05004199602043663,0.8803348634474737,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017569895172824104,0.02941901525808053,0.5509418461768296,-0.0403953253286026,0.07553511567425081,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03258115613233368,0.02536284680500907,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004066309967039593,0.024595131809337107,0.8688295725352271,-0.04439425970475771,0.05252687963883689,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11329722463105547,0.06969739120833296,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09546927612162073,0.10092889590347358,0.34493072156989313,-0.29405910466258667,0.10312055241934523,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12923164934595743,0.050228384137207524,0.906393006043464,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04059335117936526,0.07763803266151266,0.6014481829686682,-0.1933555849924975,0.11216888263376697,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05685673754001431,0.005634813549724719,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11175291142760783,0.06336960416278942,0.07879646580426511,-0.23644028378757953,0.012934460932363875,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.03879310005064079,-0.06677455090839877,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11025846399880812,0.09951749344113897,0.26874795669013285,-0.30607118722728366,0.08555425922966745,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1568934713502917,0.053392499440001344,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09826237338066839,0.09167753957713529,0.2846292093368163,-0.2786490377021824,0.08212429094084563,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1668494009684544,0.04268418105736287,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07742726616299357,0.11782898265922487,0.5115925585097776,-0.30927006255928896,0.15441553023330185,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05730302205707268,-0.0201516246207485,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10275336819237357,0.10764950514852549,0.3405629271668318,-0.3145668095125987,0.10906007312785154,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1323775658171265,0.00997565965783418,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025162815143034308,0.05563659844152368,0.6513891234623315,-0.13463456202186352,0.0843089317357949,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1435170588064605,0.10643438516262055,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07852805819406296,0.03939876587973724,0.04711731965255123,-0.15604990256522883,-0.0010062138228971035,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09389814898117815,0.0027832669366609467,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11632971203161314,0.10761299112737258,0.28053436286836686,-0.3280713075921558,0.0954118835289295,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14641418625843253,0.02338760838297753,0.876035315676277,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07010054662807091,0.046550147336894374,0.133104075170484,-0.16169360028667534,0.021492507030533528,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11671476929277134,0.06326100570714993,0.7419804415051278,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11409219415541887,0.10289839436060556,0.2683796429259045,-0.31655724948265224,0.08837286117181452,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14121423709907682,0.011400259616973805,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10475083449177007,0.08801218838312114,0.23488119850808784,-0.2779254763429516,0.06842380735941149,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11578778076128464,0.019529131071344102,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022774617103720224,0.07695993490300346,0.767482391003927,-0.174202611436762,0.12865337722932155,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10990241411514658,0.0724990938575187,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19998581452704606,0.1416797078328466,0.1590866924473023,-0.47875780181964483,0.07878617276555272,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.028858116005231763,-0.2267277148549439,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1908788635845705,0.10119819326145624,0.06020116022672062,-0.3899985672982468,0.008240840129105725,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.03588272282074763,-0.24129807189551056,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02381887690268818,0.06517585158902908,0.7150198074225556,-0.15206025987050953,0.10442250606513316,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04909566598197427,0.0037899776455083798,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0768909976687649,0.04027331630416517,0.05715259142267557,-0.15613362593717733,0.0023516305996475334,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1337286264114878,0.0690137043239798,0.5594047727659663,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04044093919676231,0.06797975735508612,0.5523450412489113,-0.1741993464056774,0.0933174680121528,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08364007755622077,0.036376906557609834,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050731509638534907,0.04671026548876021,0.27828068199515965,-0.14263961515657653,0.04117659587950672,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08546210035884239,0.05202959053723022,0.874155937347676,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09444535059856497,0.11745338678927186,0.42194811717661174,-0.32554911662355823,0.13665841542642826,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06541443905896749,-0.02816727536335487,0.9283326369589645,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1198172941159716,0.07969008102897007,0.13371440134946208,-0.27661718166348015,0.03698259343153694,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10762525935785432,-0.005051632567915175,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07090933168055825,0.040989696457626255,0.08463477111785354,-0.15156152467840206,0.00974286131728555,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.016622010319932903,-0.09199589231783337,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12868671649869382,0.07400028830029268,0.08302376004781592,-0.27429124762912305,0.016917814631735445,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1483799846160593,0.003947053661823463,0.6473895945575272,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08008060266082113,0.05828230120870654,0.17042728982748304,-0.19475809021680682,0.03459688489516455,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0910648930166232,0.006736031434113634,0.7844207095472905,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002656630156621082,0.04561445837290112,0.9535940922992192,-0.09240860243547075,0.08709534212222858,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14566140215174533,0.14265222526435326,0.994341785733425,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0934859610730823,0.039901760486512165,0.01976437955020438,-0.1719975082624777,-0.014974413883686893,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0275210349592465,-0.059135929878569096,0.32215532827417326,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02675698672052356,0.053273439469506925,0.6158417953121926,-0.07806495862360263,0.13157893206464974,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.163517094235625,0.19704568595096994,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048404458177894745,0.06471507852695245,0.45504792754702417,-0.17573921433111575,0.07893029797532627,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07098014804620437,0.025723341598968417,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007291654986733625,0.05589043072633232,0.8962841641997479,-0.10267953766000054,0.11726284763346778,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1351242059236907,0.13007244417970412,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033222278539388465,0.08841639531500503,0.7073604571044967,-0.14074768941319682,0.20719224649197376,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1167904473092783,0.13890475809644715,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09452818005444935,0.130694530046788,0.4700541240332018,-0.3516854993820701,0.1626291392731714,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07223728951984527,-0.05171095503906392,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12076935766345598,0.06827864757060843,0.07791209402300116,-0.25511586757697136,0.013577152250059371,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10663542071020478,-0.036546153296467904,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05030723309737745,0.08072346332853853,0.5336068342577648,-0.20914042549630174,0.10852595930154685,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.054174950955259045,0.008124428234748416,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17238669476591034,0.11294437247928993,0.1279521462621559,-0.39461842894420174,0.049845039412381026,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08930455729379361,-0.08372817654956927,0.7288842902994255,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01417738868443585,0.04089077197352481,0.7290409302695209,-0.0662801584078885,0.09463493577676022,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13838554634278372,0.12570180372839093,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11978569387609542,0.10932275043846089,0.2740548301184693,-0.334891447990003,0.09532006023781214,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11036615274327717,-0.013878645678517678,0.8705271074351378,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002334662370116563,0.03679510980287851,0.9494486607156855,-0.07473349802059331,0.07006417328036019,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.18486911747417942,0.16767319328695549,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028377390382369607,0.034544726670026775,0.41200897464007635,-0.09634832462261081,0.03959354385787159,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0640391458457385,0.024581803486344384,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04932063200857644,0.0423580612129074,0.24516483253549026,-0.1326652484169832,0.03402398439983032,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11571425048363318,0.04657562894431066,0.8535607195906675,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06320366445073453,0.05358711240265426,0.23911794146804194,-0.16864279928706766,0.042235470385598606,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0605795210400333,-0.0158467517829829,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033549729377182376,0.07110442556467886,0.6373736985429409,-0.17345629978986313,0.10635684103549839,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09510842373872065,0.04719978051321227,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06571288659186507,0.054824957250610346,0.23159822391081133,-0.17358763111079115,0.04216185792706101,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08201196088862463,-0.0026634878054108916,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003555838547851624,0.07597318485208027,0.9626995900891284,-0.15304228262740566,0.1459306055317024,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13382498122305791,0.11175578568507248,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0570483964641009,0.045680677631229655,0.21265849730235092,-0.14693066315506964,0.03283387022686786,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06621040212644458,0.005165318012592461,0.8287104327864808,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0071923078742780295,0.05717148214054444,0.8999696524277082,-0.10529950860791207,0.11968412435646814,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.066027607430276,0.054343517832340794,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04271040976967581,0.08186006799369754,0.6022164667880217,-0.2037800095279817,0.1183591899886301,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09251570590522136,0.031153290131299877,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03493679818431092,0.041199577935282734,0.3970961274769592,-0.11600195841308121,0.04612836204445937,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0429094833260004,-0.0034940676305670482,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0071284232691434905,0.056527210535670704,0.8997294629948172,-0.11835255732599474,0.10409571078770775,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07005261580604157,0.03662985436820801,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0075373922123054,0.0708235859827691,0.9153138622103616,-0.14689137672855154,0.13181659230394074,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09648081719713371,0.07872555872466556,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03518430196392091,0.03763670383078225,0.35059596343552135,-0.1092390758093656,0.03887047188152377,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.08123324922321123,-0.12944848911842413,0.9088510667694087,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0048810886138657816,0.042362830560873435,0.9083442934185815,-0.07847291206439104,0.0882350892921226,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.20669217670614223,0.18660806762485524,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.182736641061633,0.12363472579485477,0.14041001472747136,-0.42600294034614294,0.0605296582228769,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04633339608061066,-0.14489816098883312,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11732776493254454,0.045100511590253384,0.009726342783223407,-0.20606848466046163,-0.02858704520462746,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12480846337389004,0.030160907528278918,0.199353905835858,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0211067817040111,0.0585772610219809,0.7188495883984862,-0.13636463842207155,0.09415107501404935,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12728635321040008,0.09717019527134399,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053322427962626276,0.1634121129628421,0.744411972154192,-0.26821069894133015,0.3748555548665827,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.20427113089810478,0.23049372372072194,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04794412923283774,0.06929176113053533,0.48950585278776915,-0.18428406279730464,0.08839580433162915,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08441763763917923,0.02416153753426189,0.9415307631280134,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08361986587151812,0.07598786208184877,0.2719927241494151,-0.23313518917854306,0.06589545743550682,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.17251145211897603,0.10597681205697868,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08975440972433289,0.06383711378041146,0.16072508506461894,-0.2153616638879618,0.035852844439296,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10768640812694649,0.0019595410387838,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010704910780653729,0.1256447386987814,0.9321573442076991,-0.236516332371841,0.25792615393314844,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1033073176625768,0.11246636347762706,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018024246323023695,0.03637643259050313,0.6206025033617679,-0.05355079119634941,0.0895992838423968,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09837361965579203,0.09461701796257074,0.9580596405456464,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11366295471163478,0.046248107079774226,0.014529187889918329,-0.2046617075772203,-0.022664201846049267,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0017859330274702433,-0.11154237001695025,0.262949343295113,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05190973363528446,0.07940053260832301,0.5137427053282588,-0.20813989959121232,0.10432043232064342,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09303585355132608,0.0030283250364842463,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09855357552309946,0.07048506163060062,0.16304351611816906,-0.23724147236988,0.04013432132368108,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09909834583303091,0.005552413771720624,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14234004686430018,0.08679263719842265,0.10201590547857886,-0.31311507403132,0.028434980302719653,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0648978728151251,-0.09777077897553371,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09626743241169365,0.04342970186704011,0.027371827776785058,-0.18172063161848231,-0.010814233204904988,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12509264313798418,0.027664168344774392,0.3921977777836097,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15377713651768338,0.08729176003759706,0.07911172225705589,-0.3255342483311787,0.017979975295811995,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08430925140285324,-0.08636178846960066,0.6349735604413647,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007712447538670549,0.07286248854411874,0.9157701154582644,-0.151078219823381,0.13565332474603992,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.17506810900153144,0.15993060874985648,0.9897049933979173,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07259748782241204,0.07882865178515547,0.3577887612979419,-0.22770240898494273,0.08250743334011865,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12500811005652404,0.0363792944459643,0.9120511198404183,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06968114303173599,0.055176090822952856,0.20757598334059044,-0.1782467853882166,0.03888449932474462,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1132249756072583,0.02144971296875189,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001509030764455565,0.08266874292596625,0.9854479722067597,-0.1641697964094686,0.16115173488055745,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12453791946650002,0.1097067219807108,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017801097470258483,0.08537655569941278,0.8349742857983864,-0.1857898127533422,0.15018761781282522,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1483891549644122,0.11657475454618149,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02074881304325176,0.07052728911428045,0.7688047544636932,-0.1595197975793271,0.11802217149282357,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0903485768284634,0.05323157546408507,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12409308825027773,0.11094321702870698,0.2642047913240911,-0.3423873066729706,0.09420113017241516,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12412687604841346,0.0263616285489014,0.8687894090847701,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03421775122149774,0.04223531049498379,0.4184623683851372,-0.11732084072318945,0.048885338280193966,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08223095153678124,0.015646232069560045,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0681006264695203,0.11360228286494428,0.5492991046530168,-0.291626879026447,0.1554256260874064,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1397521225986836,0.05797258805942634,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03168370124489401,0.07019783820678815,0.6520528346694856,-0.1698064512130005,0.1064390487232125,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08696207006028034,0.03424019093231163,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02041480435639492,0.0871070152787204,0.8148561209601924,-0.19180840847805697,0.15097879976526712,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1258218258846469,0.09133996231365388,0.9770888048613304,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021091782097863485,0.0894637694582221,0.8137757867903356,-0.1971225855491215,0.1549390213533945,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08071586342490517,0.04603555400064057,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05472898872011782,0.05747055265090789,0.34168630761093244,-0.16780926265884782,0.05835128521861217,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05573118450984886,-0.005450423025613715,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044428748470747965,0.09663796879894716,0.6460210400569735,-0.2345756581593701,0.14571816121787418,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11192126365208081,0.06899937538367791,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05885032929772549,0.08287743423283042,0.4781812261413081,-0.10422106177301083,0.2219217203684618,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06566421573646962,0.09024635006101045,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024140581081796,0.08870097794685451,0.7856819918938536,-0.15038933767138832,0.19867049983498034,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08652514714306737,0.09688473382785873,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003449435473050394,0.08067395807327969,0.9965911783196788,-0.15839084126516223,0.15908072835977233,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06275926701949297,0.038155932798649726,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0667335720811054,0.04472406777076007,0.13668197364811904,-0.15473359299428485,0.021266448832074028,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07927338901323715,0.014076439110322988,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05957113729492807,0.055684104549045405,0.28553664723897,-0.16913635819487816,0.04999408360502202,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09840337714360921,0.039427391496859386,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0500671442784375,0.13441481747746797,0.7097874704941223,-0.31454457977663874,0.21441029121976374,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.047799699864506585,-0.027458940283700838,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0355690685650669,0.0465034775429534,0.4449295450852133,-0.127070293750826,0.055932156620692224,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10278993159995767,0.08093634926790488,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07046547281646615,0.0977571681458175,0.4715607893727013,-0.2628145427923732,0.12188359715944092,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12842871954015553,0.05113883849936185,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011767680075552681,0.04716486928746495,0.8031380090735749,-0.10457027363520718,0.08103491348410183,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04125203156157188,0.014610388541397555,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09464742557146621,0.09159256353155368,0.30224173813696104,-0.274866889229869,0.08557203808693659,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10043343285753749,0.007604876760207836,0.8904632102898862,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002136659033839086,0.08342068062305076,0.9795823944344207,-0.1662769531825654,0.16200363511488725,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10660223349554278,0.0882330772129221,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08756524837376678,0.053595233275625556,0.10330740071386409,-0.19302036201137912,0.01788986526384556,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09550973693432983,0.021891856411950676,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0427497053106746,0.08317458930747892,0.6076340777730416,-0.20640578498615858,0.12090637436480939,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12728938657639627,0.07391943792699163,0.9536178942986169,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09526166140591975,0.07321000371781472,0.1941494037396953,-0.2393112118905391,0.04878788907869959,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12380415794049127,0.036036937105692494,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05628438145389922,0.04500214996069218,0.21198251864599535,-0.1448315627607852,0.03226279985298677,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11022738897695293,0.061561292440262344,0.8272946081671145,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07108956650248499,0.044737636565792924,0.11306906176268867,-0.15911628566352456,0.016937152658554583,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06616588007575414,0.01122160321090762,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002686497597926999,0.10417501577686494,0.9979440462081607,-0.20524561236488972,0.2047083128453043,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1375228929624456,0.13232714337560772,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06439536860757045,0.040954184622914745,0.116880183568106,-0.1449776877689534,0.0161869505538125,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10303281221691554,0.04438511746005626,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03426394856502987,0.043871070589562966,0.43538797641956983,-0.120585594197835,0.05205769706777526,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09065805536238189,0.05026705414337188,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001853991656031301,0.08453665890597753,0.9825168887389203,-0.16819010825855543,0.1644821249464928,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1293473121132695,0.10438755991690103,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06255570612666132,0.02924443760224749,0.03320900720837142,0.00501373266881603,0.12009767958450662,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0413181148819161,0.09983826374768848,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030188801128689137,0.046814434042850975,0.5194926815842184,-0.12230187089518574,0.06192426863780747,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09366791394377186,0.04026927758123963,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0144532463781445,0.0769719049954895,0.8511770453110563,-0.16590479331812943,0.13699830056184045,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.01543954939629259,-0.02585298759107363,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035939896944915346,0.068443613019185,0.5998862280631609,-0.17061099636131533,0.09873120247148465,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1113297041626192,0.0621626536794602,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07916093546472684,0.07772046148675685,0.3092159128203581,-0.23208535797640317,0.07376348704694947,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.016065365558510184,-0.04170229877714984,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045874445845579204,0.06361784359119407,0.4713933858299021,-0.07930136765984144,0.17105025935099985,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.094683309795432,0.10669811021110481,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05704427539621834,0.07920037562296921,0.4719104646518286,-0.21288060823778512,0.09879205744534844,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.0011137193603686008,-0.039552913509117646,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029001790851424777,0.05648435082704611,0.6080023655851177,-0.1401415932398189,0.08213801153696935,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04374330883297448,-0.01962516985238917,0.9536302663534211,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04291217368795568,0.06687715027862345,0.5215687151943393,-0.08867672053557818,0.17450106791148956,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05722659372859844,0.0674097230279974,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05359697443366481,0.05663396509367829,0.34469201196085364,-0.16503116101492857,0.05783721214759895,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0873667014192829,0.020078795476564104,0.9063150682163816,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014375241294106637,0.08011390128415395,0.8577129651281379,-0.14325856394422504,0.17200904653243831,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11779040348214798,0.11288291523834536,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12400270200922751,0.11030400793740248,0.2617992320972895,-0.34103919911526803,0.09303379509681302,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12986138591210597,-0.0008650234850692828,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026316367017429076,0.0609616804918584,0.6662680035138361,-0.14626585787508795,0.0936331238402298,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1496861969581016,0.12108488025995151,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013692880910828053,0.02862486278061592,0.6327327877059166,-0.07001576585596646,0.04263000403431036,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0727210273559292,0.04102848169770157,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04599634630902527,0.053403860669931386,0.38974050402710925,-0.15107491116333782,0.05908221854528729,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1114552631389375,0.06994356025958788,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03425739730140781,0.06420441683841134,0.5940218447473313,-0.16058736472428536,0.09207257012146974,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14991881970253115,0.08746974065900363,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08227297466651483,0.07375038039738131,0.26547175709980286,-0.22738578172579538,0.06283983239276573,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13549856576446304,0.06266045744461159,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013726071372336116,0.06901369080831711,0.8424794500126013,-0.14951886789426108,0.12206672514958886,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0863935283011174,0.04983224789635513,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09107333159077498,0.0740711862910749,0.21979956547624058,-0.2368173631061763,0.05467069992462635,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12847170499300514,0.02897723823566652,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0957025221852074,0.05576009109063378,0.08709806282403057,-0.20541725581023365,0.014012211439818845,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05719293805740391,-0.03991401566221164,0.6570209000268399,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05691005593538216,0.08732410464642032,0.5150691108209172,-0.22873080968474668,0.11491069781398237,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.17313275635072717,0.10672907994266065,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10798122974495152,0.0413819392851639,0.009509193352945271,-0.18940520801964628,-0.02655725147025674,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1272089105028098,0.019659090522171088,0.1989347711166319,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10303352835573698,0.11805024549327418,0.3834488139677167,-0.33531168618032314,0.12924462946884915,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10999695606441635,-0.0037462067863688825,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12931186295644764,0.11795304599006372,0.2737959205127003,-0.36139876898436996,0.10277504307147467,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09213195918378983,-0.04194583820292192,0.870270919138952,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036618856013848726,0.0902086169062665,0.6850693393685641,-0.2141152370449683,0.14087752501727083,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13426313889759206,0.10605400471996673,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03231879522014816,0.0750208134752725,0.6669138754878003,-0.17993133325193902,0.1152937428116427,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12911981695849786,0.0797277886236834,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11522790403395469,0.03931583950219038,0.0036310575812478854,-0.1925865807121508,-0.03786922735575858,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.01459217439024656,-0.11994478429972975,0.10149061647868209,0.9699148959817107 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09905447389171755,0.1501301683325216,0.5098765223111031,-0.1963448180662135,0.39445376584964864,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.15511510770179754,0.16239969662184295,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09980537119059153,0.06661578377458027,0.13508933321173403,-0.23087999515723162,0.03126925277604854,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08317565867067353,-0.028550283539366825,0.7471520865805139,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10937351845883968,0.08007361176765443,0.17295348129107646,-0.2669280491930562,0.04818101227537684,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1798183283611763,0.07423938896212327,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04495797374579039,0.043826494129443706,0.30577494019386964,-0.1311919097936169,0.0412759623020361,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.06533108283415603,-0.12142662161545749,0.8944539216937829,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018255383350456213,0.06492185334867677,0.7787515744174316,-0.14599699401273766,0.10948622731182525,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0658435064179348,0.028698409784871124,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02427530009570285,0.03907290773929932,0.534869097979175,-0.10115597910328311,0.052605378911877415,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09042150315902928,0.07082309052385626,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005595575972775898,0.09258142209080494,0.951844410098323,-0.17656958668466072,0.18776073863021253,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05501808571727316,0.041227473084549354,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05010754173941352,0.034572057802356615,0.14824318529513084,-0.1181322532932241,0.01791716981439706,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09948615647652233,0.05523765083646736,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024800098481968402,0.05700897739268184,0.6638489522991908,-0.13697216718800143,0.08737197022406461,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1069977448965126,0.05069788995390283,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004462949662823381,0.07749888241779532,0.954114365605046,-0.14802548919006586,0.1569513885157126,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10920974445751887,0.09101756744779081,0.9945843511717473,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047866474343281236,0.08570606232072558,0.5769077531844196,-0.21650353381802442,0.12077058513146197,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13526117708479996,0.09458402478652365,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08198284446095594,0.059197476452017804,0.16707435731050943,-0.1984610501663598,0.034495361244447895,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07177692680326765,-0.025451876703165097,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04262992853464412,0.04186327153116247,0.3093205742650636,-0.12500098630870754,0.03974112923941932,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.061975344665682074,0.010019281372975346,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11423576871320541,0.07833085862461375,0.14574633271878154,-0.26836122153303876,0.03988968410662795,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09553093065239564,-0.0186075273534533,0.7646625175952992,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05207002340456992,0.07442246318179187,0.4846659778173549,-0.19850523475378815,0.0943651879446483,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1156217219801443,0.05483158887932917,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08549768736116085,0.046001363133058706,0.06402981298426635,-0.17601094162267344,0.005015566900351751,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07482223418646694,-0.01673650807317746,0.5879399282333936,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044093972962903794,0.09666885123925455,0.6486118054045802,-0.14611370166791524,0.23430164759372282,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.15584185024999866,0.1887328280368183,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1439079526558908,0.09222563402495045,0.11968474382160565,-0.32537305919597387,0.037557153884192285,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.005654424406476265,-0.13837224000643902,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1556297754431654,0.08046037026693778,0.053990379934774395,-0.31394530037405777,0.002685749487726957,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06423323755811132,-0.11385041799140888,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13063382213536254,0.06024157845999029,0.030878496897730867,-0.24916642501698077,-0.012101219253744286,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07260800665970167,-0.04605552715812935,0.42002168600416523,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06451457940373456,0.06679385798101053,0.3348567391719671,-0.19593958594224362,0.06691042713477449,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10530300260023316,0.033280095738960715,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08662943624525823,0.06828500245875542,0.20551640132634164,-0.2209884501709914,0.04772957768047492,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.01534559843621421,-0.09764278637744267,0.8193818150318936,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1563221652888649,0.21836842431517312,0.4746122644285953,-0.27334416124050964,0.5859884918182394,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.3818547239731472,0.5045992432216055,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03545048762718214,0.08306521727982712,0.6698356093661437,-0.19889136458966586,0.12799038933530157,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13828137765476822,0.09223249758812585,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024191996249178584,0.08099208073186719,0.7653716256123018,-0.18355372592766625,0.13516973342930907,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.137021336371545,0.09325188651977938,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08614103671298863,0.08228881910635187,0.2959985441082826,-0.24805425622148186,0.07577218279550461,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.036942268207738264,-0.06739710099405925,0.8833721946393759,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04164426687829572,0.0545876892079521,0.44610873975636656,-0.14905215778222916,0.06576362402563773,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12807042546207056,0.07067647735917411,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05556788898925721,0.08678936672427737,0.5224740377021099,-0.22633648110223287,0.11520070312371844,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.040387525710111734,-0.038953445919359245,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05731903816369605,0.08763792061842847,0.5135669203048326,-0.22975726285155293,0.11511918652416084,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04122890690437634,-0.040134148684292444,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020241749351709408,0.08779958105341595,0.8178199249932349,-0.1929980605278672,0.15251456182444836,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0854647862139746,0.07035317508733424,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0024240475157417687,0.08375782228494694,0.9769300908674019,-0.16237961369184956,0.1672277087233331,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08727086220097774,0.05072057665601457,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041264388415668256,0.07705131875935871,0.5926563471024107,-0.19287219155571766,0.11034341472438114,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13864157171471594,0.08386840321325748,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10746347402553383,0.04320914735899742,0.013404648076196308,-0.19248270552125168,-0.022444242529815972,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.02844707154723918,-0.09010232878156893,0.2480344649940285,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1295965260287184,0.10878016041782525,0.23441999125742186,-0.3436346685513021,0.08444161649386525,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13410035058145248,-0.002226422005654859,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06917198287054235,0.05823872442244431,0.23584541272160311,-0.1837637278209569,0.04541976207987218,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08087542829200307,-0.002352847143364895,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08330353549706043,0.05815931678555378,0.15305273207759443,-0.19773903630298323,0.031131965308862364,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09880381791255705,-0.013488316873532774,0.7699192568009788,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13348278748237308,0.08778170033586698,0.12937072741704203,-0.3062039161808028,0.039238341216056655,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13162360180418461,-0.002174200715208291,0.7319635311735422,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025454148081678934,0.036261116457633004,0.4832240399493737,-0.0968022871410056,0.04589399097764772,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13234757843142603,0.08826093224371083,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16895948148287968,0.03497221939056194,2.133806100958267e-06,-0.23777155943438055,-0.1001474035313788,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.00010669537495762708,-0.15510020853938492,0.00015979389461704454,0.0015271015592713227 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07567128058409942,0.11891311855406471,0.5250113526624733,-0.3096472456784578,0.158304684510259,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1202506283609523,0.01945754703881438,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0218348127768156,0.08348635163394102,0.793851146020685,-0.14243469704078401,0.1861043225944152,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0837957721450356,0.07220700874955428,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013067414228281426,0.05977336099013634,0.8270925627678039,-0.1045439140646689,0.13067874252123174,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10619484001268892,0.10104645993705881,0.980914908860308,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08416970666151424,0.08982381031073197,0.34945818723067545,-0.09256952077999586,0.26090893410302435,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07889531550857463,0.09819904121432504,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028932052490144855,0.04367423686062429,0.5081726848139471,-0.057002298937853024,0.11486640391814273,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1081098025630004,0.12541759987425014,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14582490146593668,0.0751857971306207,0.053341225310108854,-0.0021122618927674475,0.29376206482464085,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06169162278457256,0.13457583989126545,0.5414611847974988,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007368482088909038,0.06511332510640264,0.9099735756965055,-0.12074987245030518,0.13548683662812325,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1059196442134206,0.09826391826088438,0.9890962952045544,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0692478876931039,0.08394602571668441,0.4100551369953147,-0.09592608656413489,0.2344218619503427,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08645651118043185,0.10095395727367468,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015962513327083587,0.07523530088891339,0.8321150586706341,-0.16399708132678253,0.13207205467261535,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08622792324817065,0.05540564269940329,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03936572102097669,0.04811301738804889,0.41387358589724765,-0.05530246877889119,0.13403391082084457,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0648775701563233,0.0759015450895672,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0049537513361067155,0.07861230999303732,0.9497950745573182,-0.14972549114423492,0.15963299381644833,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09893990938400347,0.08017155039144533,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03907660993182083,0.029532478454186075,0.18674946392165823,-0.01903211879355443,0.09718533865719609,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06531004412561943,0.07947179315491783,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015301380726286628,0.05784437607164983,0.7915493292996628,-0.12911719752779338,0.09851443607522012,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08564195112403496,0.05674814716234127,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12673053435056053,0.13094123702838487,0.33387492604212454,-0.13091221084778454,0.3843732795489056,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10132108633002475,0.13639564537332413,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01658820613432186,0.05481424478847016,0.7623773354523864,-0.09126546031770746,0.12444187258635117,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07601165500570056,0.08514103971661674,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014235982378301888,0.045796236242486646,0.7561192065395099,-0.10434562463491545,0.07587365987831168,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04981907024973005,0.012953637174591323,0.9654293488033827,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006771651703478134,0.06282287797993716,0.9142321123965319,-0.11683997066498147,0.13038327407193775,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09690978856145963,0.09088212542925395,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027288041257634656,0.03432044806000197,0.42716419639580705,-0.040241597649773135,0.09481768016504244,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.059465097685510074,0.05243453054217575,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03040854292135764,0.05802340816182908,0.6006005581875283,-0.08375954120432584,0.1445766270470411,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06440480445907211,0.07810362769999488,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02780212040865121,0.07369874912635045,0.7062525033807818,-0.11720909587060954,0.17281333668791196,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.048349294436412824,0.055481982393839835,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09936888739361935,0.0793328599701067,0.21130820373303486,-0.25546589923644614,0.05672812444920747,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1928914336041499,0.08867997167122882,0.8262879414940053,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020238350938848296,0.05144965610434247,0.6943214921665899,-0.08099507971340747,0.12147178159110406,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.01175750236968849,0.007457969629466383,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04025269936354357,0.08970756139681933,0.6541313954270045,-0.13665217960484144,0.21715757833192856,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16570732182700684,0.26310885776697857,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24066559838452176,0.0905748219286364,0.008524971229179203,0.062050466489557976,0.41928073027948554,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15848102405279632,0.40432603873395767,0.18849922456051393,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09946484881719075,0.05666734222851556,0.08076460593229323,-0.012284140479836711,0.21121383811421823,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07023288833503358,0.16908671748174714,0.6398297823258919,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18432678878153316,0.1268675530362463,0.14783247402981847,-0.06585824317596325,0.4345118207390296,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.25490754085327455,0.4626236281100312,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15156378454082514,0.08614795527043978,0.08006379243191813,-0.018321488932134755,0.32144905801378504,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22350117007054776,0.3123959235606816,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15792904576134767,0.09247022404720658,0.0892239070710599,-0.024423852238959876,0.3402819437616552,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08424770521902626,0.23743966048349208,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17942061660438785,0.06905005241784325,0.01006988139852632,0.04325270639105433,0.31558852681772137,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22807250714672858,0.38510595737411724,0.20399134085447534,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09896674123282147,0.049906594676063995,0.048745405010495284,0.0005500642724512311,0.19738341819319172,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1631345177126951,0.22239738718906482,0.5228932769909616,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03707703435334134,0.04768698190967879,0.43778680401328296,-0.05696252743769402,0.1311165961443767,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14094339430522979,0.15005729791563507,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18789804920852404,0.11361392518744581,0.09974667714307481,-0.03615059698643175,0.41194669540347983,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.248105083951432,0.434029423762415,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.191869409441335,0.047551182557500925,7.795443462424631e-05,0.0980976463462729,0.2856411725363971,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15513554202334962,0.3793801839426617,0.003916470266121944,0.037428512926404645 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21154399691314757,0.10321752341475292,0.04173204671309696,0.007997236720525464,0.4150907571057697,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2446789277280487,0.4364067620843861,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11324058265899774,0.11846062985822049,0.34027109133189004,-0.12036584985662489,0.34684701517462035,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15888383156174343,0.28886057132806303,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05037833164365223,0.07002143168760103,0.4726996061987714,-0.08770515546724915,0.1884618187545536,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17382346028630413,0.20201996886024634,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058362861378056075,0.15210754258409695,0.7016164128734848,-0.35832159386425877,0.24159587110814662,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.029212699441850908,-0.02669464472938219,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-3.175094101095458e-05,0.09112155876326254,0.9997223311483812,-0.17972505742963304,0.17966155554761112,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.025469660494695987,-0.06149300632108512,0.9998482883527592,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0763375573011655,0.07200125088211243,0.29033364258583994,-0.0656501678642634,0.21832528246659438,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11132042122146948,0.1527793034649076,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10053115206684622,0.059354927019027524,0.09188931247191086,-0.016517801410231375,0.21758010554392382,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17507721062716228,0.2964948814795188,0.6673534880164945,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08595382316724264,0.05463409018630277,0.11725433748015406,-0.021785557565699734,0.19369320390018502,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13221778073012364,0.2118315001154618,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0845825234325091,0.0755943387573271,0.26453828192797646,-0.06449083382223617,0.23365588068725437,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12252786726722965,0.24043156540124794,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12404049922759323,0.086076601595565,0.15115073652554925,-0.045704063551405924,0.2937850620065924,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14102063641401655,0.2547514236246882,0.7686319965021204,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11288738842789094,0.08467379303895346,0.1839969454702752,-0.05409081135941533,0.2798655882151972,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17368427805271847,0.32227837638881957,0.8036298987262369,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04816478705001548,0.07493639799228524,0.5211349626255942,-0.09961109951668784,0.1959406736167188,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.025490384809305967,0.05321439363039736,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13879760371049268,0.10125811552556664,0.172010776831012,-0.06088516987844847,0.3384803772994338,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2599814451532205,0.3919471950607346,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10217524673869602,0.08833995416516514,0.24882356702937536,-0.07203268686605488,0.2763831803434469,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15224124044806128,0.24207963089426449,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1070846274525433,0.043805923462896294,0.015379318826237623,0.020698580751057877,0.19347067415402872,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17117836598020023,0.26966947920677425,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06410995480559742,0.07892203986822661,0.4175835831138026,-0.09152568720084897,0.2197455968120438,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07611237299015634,0.1402214244187453,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09642681958498238,0.038070377963712536,0.012089177172496206,0.02135136885279887,0.1715022703171659,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15208389400268643,0.24639714909311744,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07680477201668193,0.060329215821040935,0.20447734075904087,-0.042165496006423955,0.1957750400397878,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1276938522283789,0.20734406335628902,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07367045044380524,0.06115304422491707,0.22976103685732324,-0.04692442159048038,0.19426532247809086,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16240542227581276,0.21129382012260725,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09177757005460054,0.07398140002832783,0.21624027315489885,-0.05411504383588299,0.23767018394508405,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19715474442513187,0.2771045971978484,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17055176344826087,0.0758433863949883,0.025630840839982686,0.020987279899234462,0.32011624699728725,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17959578282784963,0.3258154656352149,0.3753830527449863,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11553495339085325,0.09521235528859029,0.2264052935338867,-0.07222547534397734,0.30329538212568385,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21043388525101528,0.314649075490529,0.8421767666691623,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033526300399972675,0.07564203561444134,0.6580882360478519,-0.11564111589063963,0.18269371669058498,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09412875662576528,0.13009667397077046,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15556030308576857,0.13453409248426038,0.24895616932455697,-0.1097432786577146,0.42086388482925174,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1713741922103353,0.33240185236323067,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1405923812077032,0.051073205008069,0.006458906344159338,0.03987512828279749,0.24130963413260892,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.137780167514939,0.25010817251237144,0.1553660562422328,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001933798046539768,0.08202864402482808,0.9812156198965005,-0.15982812165343616,0.16369571774651567,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1474283290630325,0.13098216262694665,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06319404720636747,0.09721003877879622,0.5163957708077391,-0.12850584828632944,0.25489394269906435,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12388732655809687,0.15994235915003246,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12429325455012799,0.06340621617299089,0.05136720016814372,-0.000744911946324256,0.24933142104658024,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11276889995384003,0.21073386450446252,0.5316325649082267,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039661038108274906,0.059808854072328214,0.508018649778639,-0.07828306745157329,0.1576051436681231,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17411508339694223,0.18379854703091167,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14708805117740278,0.05031173465285144,0.0038639110834294732,0.04787243110183849,0.2463036712529671,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10994440222750934,0.22118084919656114,0.10548035157916945,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06192153484944437,0.08326693063994096,0.4579691815807122,-0.10228230769810193,0.22612537739699068,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15889684395586895,0.20298689014171356,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023376015021888873,0.05597045050796095,0.6766561458703267,-0.08699869162204715,0.13375072166582488,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13637573298282354,0.13602292681701245,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.091220438797997,0.06432850651157741,0.1577507955178166,-0.03563650036578521,0.21807737796177923,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2030264165183122,0.2637259827206786,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06520238853988895,0.04558316278331601,0.15417697844246325,-0.02468840516375778,0.1550931822435357,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09118787917963539,0.14597712097773766,0.7721494352531693,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012208078030909621,0.033135525848942075,0.712947224215033,-0.07755191414224022,0.05313575808042098,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12978331229425222,0.09995213305244274,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07207164856422592,0.07574855211798724,0.3425313661176915,-0.07730582013305666,0.2214491172615085,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16483127032961817,0.20736114281689128,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001986839737554531,0.02930907300252774,0.94602181622532,-0.05581116448253974,0.0597848439576488,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08428406947045716,0.07162781286005376,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017422450179995767,0.06647878880112416,0.7935358189327071,-0.14851978360104087,0.11367488324104932,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09285449990974494,0.03790943727987533,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011337632694069283,0.04909890603528354,0.8176199191049719,-0.08548626815003398,0.10816153353817255,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16002037478961162,0.16341811629612138,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09685057837579526,0.03316337252669829,0.0039012401080264353,0.031451828129229795,0.16224932862236074,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.00917386663267094,0.09356485905532942,0.10605494512847206,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04316954162336111,0.04743267913495128,0.36386457644089987,-0.050368530651249944,0.13670761389797217,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20208525032129682,0.1960951536752066,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.191098460239719,0.07337117812455124,0.009897482538290984,0.04640921460883998,0.33578770587059803,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14498851735241564,0.3424625432710978,0.20196970794075533,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1581607014590427,0.08502287034123288,0.06433829660433264,-0.009505884869473652,0.3258272877875591,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09702704212249746,0.27268170791957513,0.5880149074273526,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06943668083562296,0.045015960333374024,0.12455120007277895,-0.019335579723267965,0.15820894139451389,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17126592764644707,0.2217855232474731,0.7259506085296737,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18043781256116875,0.1544047515864278,0.24396879644335154,-0.12405105622786777,0.4849266813502053,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.32304246207270004,0.4744991602506879,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09996817119259062,0.06923211020090159,0.15033158132454533,-0.03655876015090963,0.23649510253609085,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15105553018995513,0.2336172881700233,0.7680634195565342,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13768088742750068,0.11183031010948451,0.21972379974564488,-0.08285043865998734,0.35821221351498866,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23342996485610715,0.41050481306819114,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07783170821631902,0.06539298678099997,0.23538702499818648,-0.05112440464357382,0.20678782107621185,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1817545621994673,0.234636353459896,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09427562872472661,0.11182431993822385,0.40020709036521707,-0.12624388464034017,0.3147951420897934,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17405470741658144,0.26331372200696,0.9218931756584715,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07289328030038113,0.03232820608044892,0.02524117851484482,0.009141492882719857,0.1366450677180424,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13652421556770378,0.16625221843736562,0.37388200177512143,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11410606453855858,0.08832402816406477,0.1978966815278538,-0.06007046271367038,0.2882825917907875,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05089380369828489,0.155853492867229,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03576031297088724,0.0847745417928084,0.6736078741225784,-0.13141656511989094,0.20293719106166544,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19822773138629138,0.18996060610730875,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.128227003750117,0.06418474205848702,0.04710920393938412,0.0016535706005202655,0.25480043689971377,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.160438646502679,0.2916555099626582,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10640205876578132,0.07497289200861648,0.15741098114596652,-0.041445794638963585,0.2542499121705262,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10501566576911744,0.17618644945409484,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11784922758069184,0.08408631654264066,0.16262215284319745,-0.047970458288068965,0.28366891344945266,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15591586645363772,0.2553617068696501,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10798703782425097,0.060920074380352476,0.07783233868143413,-0.012148413604745043,0.22812248925324696,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1280442907445396,0.19419772125415916,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12341861392434109,0.053708969168952486,0.022611423598813584,0.017503588006724954,0.2293336398419572,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1886200477568547,0.2903767881319269,0.35125142960348776,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11020424311888748,0.07978410177619309,0.16874947386090405,-0.04713140003704365,0.2675398862748186,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1596883679391635,0.2150222869628316,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1983064714822543,0.1253668325231476,0.1152890690672421,-0.0489191133940676,0.4455320563585762,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16261335201566982,0.3288523741378972,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11753465732740982,0.08016020407140664,0.14416737026953133,-0.040542666128135854,0.2756119807829555,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16466208877023977,0.26045208330937086,0.7634426852565308,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08445838994445634,0.08674231251226523,0.3314084156355541,-0.08659896639746051,0.2555157462863732,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18784817718964336,0.25170940415926196,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11392795362782543,0.07247623092861358,0.11756212411675868,-0.02899644049092609,0.25685234774657695,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14005688156726845,0.23343489547426977,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1985017264389988,0.11877486615987254,0.09625332289122258,-0.03572438555565155,0.43272783843364915,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21489479913425236,0.4589638197304066,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06519812859897847,0.027962024131959504,0.02072377190439244,0.01005652829514117,0.12033972890281577,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14176045173041735,0.16118738255089787,0.33233394217589335,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12032077899545424,0.09384768637064402,0.20131169129085788,-0.06474849878172961,0.3053900567726381,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23886967621223862,0.3490221243870886,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06519330569689041,0.057893952349352594,0.26149405690385613,-0.04897458019691561,0.17936119159069644,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14146782567099797,0.1739807706885004,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07181027533879975,0.06884612031859264,0.2981947605641354,-0.0639554772105202,0.20757602788811969,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18061636588583543,0.23140574766226965,0.8855940007795015,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057913469166859924,0.0739875436504963,0.43471132719363914,-0.08799126005391704,0.20381819838763687,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.154154036320415,0.1925263223304533,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09237403577698045,0.06103545876403872,0.13176029366142533,-0.02798895567331393,0.21273702722727483,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09023359674458178,0.17253236830621818,0.737305253544566,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12648684735193527,0.07230939272448118,0.08179811655727488,-0.016108538912296744,0.2690822336161673,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17024284758494299,0.30929450214315785,0.6428846031996515,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06485755910557513,0.10831725433441466,0.550007994299516,-0.14874595959286985,0.27846107780402013,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1379437879749,0.15168123023601982,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09050241150935806,0.08433060706912132,0.28449395408553324,-0.07579901954729185,0.25680384256600797,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13720290714272676,0.20092148739280366,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004143706181547784,0.029796607885384473,0.8895390443299722,-0.06290313771168923,0.05461572534859367,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11883443767372613,0.0814088175491926,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09459162542775208,0.07260314626913397,0.19413626723338084,-0.048583047960710904,0.23776629881621508,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13395519029822428,0.22506339114995214,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06954375605765174,0.0666869952333497,0.29829475608914563,-0.061964164086739534,0.201051676202043,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10619973465895112,0.16528323432892864,0.8855940007795015,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06840523070053586,0.11596628921938654,0.5559492167566744,-0.16028231847963484,0.2970927798807066,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12651031190946968,0.15452896519123924,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07594079127830253,0.0634854497553291,0.233052080640938,-0.04925362522735208,0.20113520778395713,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1477227120283784,0.25520094704771384,0.8443484327374559,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11384032157785567,0.08774638947405991,0.1960103964347151,-0.05919709208181062,0.28687773523752197,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1821676906050233,0.2770861455710032,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03945954078668485,0.05447019308586868,0.46966031387033214,-0.14687571357300488,0.0679566319996352,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08533879473726806,0.02658340910669079,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10800382082292598,0.07709974848449239,0.1628294927316558,-0.044038230725090416,0.26004587237094234,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17982426370108956,0.29491313452550744,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07154495078104295,0.11075089740535145,0.5190281070910249,-0.14685775458809874,0.28994765615018464,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1615829539447795,0.20301680913382195,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12651503849847523,0.06130770661667867,0.04035919638823715,0.005615169524472136,0.24741490747247832,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1412356351865526,0.2869163284687134,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06378600064165056,0.08525068507957667,0.4552171581770792,-0.10432984033258792,0.23190184161588906,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14572005084628648,0.180248855249528,0.9339658313801124,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12119812371115714,0.09642236758670011,0.2102523673470376,-0.06894847042393996,0.3113447178462542,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19819470216872884,0.33891476836474416,0.8251393055567431,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11565176665710003,0.04163192035149724,0.005996232709715275,0.03355289208815883,0.19775064122604125,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0907733571660717,0.20952864007810307,0.14874404765537455,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08011761276054384,0.035582765384437914,0.0254468039985646,0.009947777512769346,0.15028744800831834,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07493696889678735,0.16778910439483002,0.3742940281840044,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10916248202359922,0.10739731897793896,0.31066230057966,-0.10262690807339832,0.3209518721205968,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19321064906765295,0.29137740740469703,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.108464497056792,0.06957362429415724,0.12059596404279696,-0.028735906047534995,0.24566490016111897,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.151125923423317,0.2688498475997827,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11285602187644703,0.09242724798224165,0.22352836435750476,-0.06941212657262116,0.2951241703255152,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11766198804213852,0.21318196661372973,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05573425547633788,0.07334993189965873,0.4482536350943672,-0.08891309222771511,0.2003816031803909,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15555252480121257,0.1600112336084878,0.9334305759126671,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025405572697212643,0.02346264652000177,0.2802099431978115,-0.020863176316469473,0.07167432171089476,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07221689480897489,0.08099000489416049,0.876035315676277,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054913368459433815,0.09055255300140344,0.544926952666115,-0.12365784872181393,0.23348458564068156,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1307892785825998,0.13363518247922343,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014349754997865867,0.08063614363509253,0.9858197655686761,-0.16045086009331347,0.1575809090937403,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.040864703778411685,0.05753998481000393,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09362777283998307,0.11055514844109661,0.3980802773698443,-0.12438891215038018,0.31164445783034633,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1412459097928667,0.1954200767559063,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05906478575571636,0.0775978399910521,0.4474638969207353,-0.0939595109487964,0.21208908246022912,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0484056049792566,0.14915381876733746,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07950673602588612,0.10802002524581726,0.4625792525737161,-0.13351064171492416,0.2925241137666964,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11968995247601344,0.1264476830646225,0.9372011503139762,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015370845773817083,0.06690654733054541,0.8185340374026868,-0.11657003494353921,0.14731172649117338,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.04003096582248112,0.08899901097443289,0.9782788982878687,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009063875226175013,0.08494755332463132,0.9151352806941349,-0.15845418462922478,0.17658193508157483,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1095922624571888,0.0715694368383674,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13387926926029864,0.04237039383723147,0.0018267982419370413,0.05032411207057261,0.21743442645002467,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1147281143710986,0.19051453188479595,0.059922001836761295,0.5726563124259477 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04340931829169611,0.07885743118620443,0.58261174945422,-0.11209891426458271,0.19891755084797494,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1228404203549789,0.1430277616808095,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0546896218088153,0.07540242105179833,0.4691223450810269,-0.09400527037632146,0.20338451399395208,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18763192131119394,0.21284280485671037,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14303128913748317,0.05379358993260387,0.008481168413618881,0.036949389594958845,0.24911318868000748,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18874999502899537,0.31509704696883356,0.18805451080253263,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08257028357967303,0.10283573868738086,0.422975807352011,-0.12022359045780132,0.2853641576171474,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21357431935427232,0.29604045710579185,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03813513566805129,0.04947288767506021,0.44172713874946257,-0.05942626350608055,0.13569653484218314,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10807592409514,0.11185025310312006,0.9325611774982004,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07164700749045247,0.05432447931205688,0.18873540787317922,-0.035481815187149573,0.1787758301680545,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1491610060333396,0.2231056926428813,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09367819625815076,0.07122839620876664,0.18997030335469617,-0.04678544598361463,0.23414183849991616,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2202224887234118,0.27137224053042636,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11035318426044119,0.0685114098050599,0.10883221956313226,-0.02475251330617745,0.24545888182705983,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19041123371483334,0.31516188774273873,0.6983913976492675,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08830081096976995,0.0644603513038697,0.1722861198471595,-0.038816128428774035,0.21541775036831395,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16842570373657106,0.2314984671457939,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08463380080849021,0.09118855613100382,0.3544760418010797,-0.09519162566028656,0.264459227277267,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1819786083492269,0.24130473400324645,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11054232317401069,0.060660289952635324,0.0699153440133264,-0.00908082882305801,0.23016547517107938,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09122139808935158,0.1902857450954189,0.6114670027237653,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14856736179566712,0.09931579357598418,0.1362696499245975,-0.04728511896111698,0.3444198425524512,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2506231861024037,0.3716967997327037,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13158720066448876,0.07288258599829713,0.0725204252177646,-0.012138532753885128,0.2753129340828626,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14281004300989733,0.26687328553048545,0.6230163802798868,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14732522372958468,0.10599773385974151,0.16612284960153817,-0.061704160052611284,0.3563546075117806,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2199576655910441,0.3533277301402735,0.7840604855201315,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14363137718073082,0.07409703147600777,0.05399345535118847,-0.0024892639455647847,0.28975201830702646,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11497207627002613,0.24586787848034963,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1488409336827955,0.08449696444023433,0.07969815711953379,-0.017788557017255763,0.3154704243828468,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.195715763037292,0.3622940551223234,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026633405439159916,0.06804315000238319,0.6959081978454931,-0.1075488756124132,0.16081568649073302,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18665381098952774,0.18293699274482975,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010482140594062762,0.051204483397936935,0.8380079083583905,-0.09049399561012442,0.11145827679824993,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.023382049019245135,0.044368381526058265,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11965882657654416,0.11656103542861476,0.305872391453138,-0.34951922567618837,0.11020157252310005,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.29430065481670087,0.0517626521469027,0.8944539216937829,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0940728732509609,0.064352066614172,0.14536844226538448,-0.03283052684691741,0.22097627334883924,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15126755280662788,0.23149190687719567,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16026752124198868,0.09597863088822729,0.09653413738393832,-0.029004016368163715,0.3495390588521411,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2721844407368019,0.45041938512099533,0.673446463693037,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04484802021957938,0.027254611125025068,0.10144902731207282,-0.008898549270536182,0.09859458970969494,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.04038545412296225,-0.01890054450061386,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028766931562320183,0.05257801660586899,0.5849065790198136,-0.07491783613429426,0.13245169925893463,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09723757233841337,0.09535641034403161,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10155245061353663,0.04128730406921323,0.014764825267786892,0.020133165376405623,0.18297173585066762,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12098693601458044,0.22526246448272488,0.2647257396604304,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08232047635241244,0.0930343156556737,0.3773162274291896,-0.1011448201588917,0.2657857728637166,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10783973882735384,0.15376556093456561,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06024191353527991,0.043086666381005854,0.16363017730088975,-0.024725745629661747,0.14520957270022156,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11553406296017536,0.18287616506861973,0.7815260814768127,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011900276820167525,0.07188843189649782,0.8686893348310524,-0.12986496733379788,0.15366552097413294,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16844045669367694,0.13454327495741647,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014580573522043951,0.058529090349715866,0.8035287430561249,-0.10083981560931493,0.13000096265340283,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1625807472246423,0.13889924872972548,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1408497030361027,0.08609021265392713,0.10341329168975885,-0.028921700987878413,0.31062110706008383,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19867214707552408,0.352101815527977,0.6840511279380797,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11370030602166033,0.0678832454078136,0.09552480050423291,-0.0201666403746356,0.24756725241795624,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1420280816500102,0.2347469565773732,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07815217656977004,0.050659931794557723,0.12450460172682447,-0.021750094354970856,0.17805444749451094,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08457697413883308,0.1450320167411909,0.7259506085296737,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15271571986792495,0.09303133485906995,0.1022703992088586,-0.03074369846037872,0.33617513819622863,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1891475228491191,0.36123753352229954,0.6839279097893172,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14227023282194426,0.048167091206880626,0.0035202945244121,0.047283887105556324,0.2372565785383322,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17037162309303205,0.2926059571851927,0.09909254586802571,0.9469972658835614 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07584310835170698,0.0642451735811896,0.2392072406394211,-0.050849496816871356,0.20253571352028532,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13766754508337017,0.21502886468582844,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00527374129734606,0.07827534464339286,0.946351766768186,-0.14908660642289645,0.15963408901758858,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2178318894244507,0.22767398926412347,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1447798229741384,0.11712283113705284,0.2178722005215476,-0.08618844708151777,0.3757480930297946,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10251511232113582,0.2784741010546513,0.8322459088982637,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047721107736983535,0.09514137148564213,0.6165195034658966,-0.13989933969779014,0.23534155517175723,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14767953983641616,0.17010107198055355,0.9562195815772346,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16441390302054598,0.09071272271491665,0.07142865313654141,-0.01447317163516948,0.34330097767626144,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09613171744012203,0.2521250792536144,0.6190382519293574,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17090781508186897,0.07228433990592098,0.019027687778445063,0.028361833413706683,0.31345379675003127,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18278051311459753,0.3425496704505326,0.31532731854968044,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04593879848063806,0.04867559174437461,0.3464349038309863,-0.05005031918317594,0.14192791614445205,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.03626731682343351,0.09653244554568595,0.9075908470661285,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04600356911073501,0.21045187752722572,0.8271912824276771,-0.36901121161591255,0.46101834983738255,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2775677155859899,0.24413515896976845,0.980914908860308,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12293324733835166,0.09656218462820118,0.20447552737173533,-0.06748906844628459,0.3133555631229879,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.185827890258868,0.2903420651066186,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09706559493272876,0.08678770355960788,0.26474032375987433,-0.07408127334788497,0.26821246321334247,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18125533492030063,0.24455208770550924,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05418433265044527,0.05413722744570775,0.31811120068263565,-0.05257522607395927,0.16094389137484982,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1073478655458879,0.13917890147002318,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10138551921272418,0.07369732274631138,0.17046828196036273,-0.04394688931256738,0.24671792773801574,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18648589831805001,0.2606181908559174,0.7844207095472905,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08664948162217626,0.049572855001763796,0.08202762167314448,-0.011109054867427401,0.18440801811177993,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12991805652729177,0.18694143905720048,0.6430699474171485,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07901421377976628,0.05798848133850162,0.1745612647871627,-0.03534008493280359,0.19336851249233616,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11890823454710359,0.16629333116589243,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09087195913409149,0.08166237169733075,0.26715364799836777,-0.07016766513441278,0.2519115834025958,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12901968173447176,0.234124135429223,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02190530340185398,0.07549800454522958,0.772009609349313,-0.12697808110292164,0.1707886879066296,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15826585312667132,0.12894637997287245,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0926234476498711,0.06577947292576355,0.16067245461850901,-0.03709482264243616,0.22234171794217836,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1971039895335553,0.2670503986324954,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025041733291789957,0.08453908159110676,0.7673764473890954,-0.1416708131658983,0.19175427974947823,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08411205761292165,0.09294306564014787,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22578317395767578,0.08760198727416023,0.010682246613055443,0.053030523960049314,0.39853582395530224,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22177958520066915,0.44552138044762774,0.21146053270432444,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06632836358029186,0.04631781099270527,0.15371277309656237,-0.025011169232329877,0.1576678963929136,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16315706453027412,0.22626991732987017,0.7711789647234355,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03712312737748681,0.06416315733233822,0.5635342588078802,-0.08940774031489022,0.16365399506986383,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1829480200444457,0.18723611097270312,0.9517733928546709,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1801621999504276,0.06511462345291699,0.006196434046761572,0.05175502443870242,0.3085693754621528,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20125107933193664,0.38833420630523563,0.15181263414565851,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0941080422790901,0.052690425754200715,0.07562050631636939,-0.009798398222702925,0.19801448278088313,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18315231331311096,0.25111536311095517,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12642757127645451,0.09562406512849572,0.18764974733984982,-0.06214475645846579,0.3149998990113748,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09374859256475147,0.25459619184219046,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06105442952804665,0.10709205866574205,0.5692483119286713,-0.15013298189800955,0.27224184095410286,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23094114792198372,0.26654555718298617,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01635558806136106,0.06126025531096941,0.7897583405405094,-0.13716188223115944,0.10445070610843733,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14978519119345163,0.08884725122123657,0.9728992869406584,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03799582590771408,0.061638404242169605,0.538318144432267,-0.08355618456363531,0.15954783637906347,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11052775741804743,0.10038429214439511,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09775663071789938,0.10422177862445843,0.34940389251873016,-0.3032837997362665,0.10777053830046775,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1913263486093408,0.01726755370913023,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059161283155195137,0.0591863095630068,0.31873519576912857,-0.05755515375154171,0.17587772006193197,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08856845102215458,0.10577345543998311,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04560485500698218,0.12280615053152147,0.7107691264781631,-0.2877807302406428,0.1965710202266785,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20187070618782205,0.08004921660559232,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046362383816448596,0.07659840613507242,0.5456955989203686,-0.10469101185613329,0.1974157794890305,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1163697051835586,0.12086732921922454,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04500845203669297,0.08682112114643843,0.6047549725256391,-0.21622122038260355,0.12620431630921763,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18231757886086317,0.06985961193985465,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08057012562108044,0.081688441751217,0.32518474505318473,-0.0805209092493356,0.2416611604914965,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13111061863472442,0.17335375511459944,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015243559251982569,0.05367928643465078,0.7767265065545074,-0.12110005029876583,0.0906129317948007,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12678244715851772,0.0816576060321644,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022714460305507382,0.09057361953577368,0.8022407736391353,-0.15589830044971587,0.20132722106073064,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15764593006465694,0.1432372859247635,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023803469171418346,0.02996088182017259,0.4278644053777746,-0.03527991342927782,0.08288685177211451,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09944124858025977,0.09102818331689581,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022758076691186704,0.05801141490453572,0.6952559967945304,-0.09164144741443148,0.1371576007968049,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09322793268770102,0.08437382735806559,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016767750761280557,0.15982158478538835,0.9165491166936042,-0.3319387092931782,0.2984032077706171,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.24084367963768705,0.0940834701653895,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10258113234392752,0.06967746998004996,0.1425470032865073,-0.03482405626797758,0.2399863209558326,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05786841627520117,0.11605363957197827,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07293532552145691,0.07221612921457334,0.3137475747685215,-0.21534679451410654,0.0694761434711927,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1002074033005484,0.005484673131630996,0.901410374901842,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11299488943587467,0.06418526494599744,0.07987563093796562,-0.013579574857031554,0.2395693537287809,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12170360333466279,0.19352266183645844,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058836457567472494,0.03761807179848492,0.11940321751551017,-0.13301995263649513,0.015347037501550129,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11448896379971295,0.02052278235706227,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06097561440124922,0.08095220824113696,0.4522065269637231,-0.09866355511952196,0.22061478392202039,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10306978475090596,0.13129837255323307,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03812572906863025,0.05054552077323388,0.45157422795268143,-0.061550921322403196,0.1378023794596637,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11226443333811562,0.1300785042454389,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14298309881946988,0.04420217266676798,0.0014267411348023392,0.055815641762371734,0.23015055587656802,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16001069791676092,0.24617818868652047,0.048607172223437634,0.4645239336088109 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06433608525183875,0.05111632112015182,0.2096491880991047,-0.03646619339967053,0.16513836390334802,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08714603824930389,0.13292031922955735,0.8238590371934124,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05113790215355433,0.11195270344516044,0.6481068226333855,-0.2713096858479296,0.16903388154082094,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.050550205538605474,0.06584668354993152,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16918070156813686,0.12225852353894091,0.16728829863297567,-0.07125902316432567,0.40962042630059936,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.006560955030370635,0.21292611054176266,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10601244925975432,0.07868551639237505,0.17874275985236143,-0.04873442117654979,0.2607593196960584,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.058693503861224856,0.05374414166511869,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13470775016407777,0.12249713041533669,0.272214271876833,-0.10620123078070604,0.37561673110886157,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.1560539984907259,0.3943614722129031,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0779578124857021,0.08154039960736413,0.33968884596833515,-0.08240361401169058,0.2383192389830948,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08034886130944932,0.13455140135123794,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05899185221076925,0.09686532479617792,0.5429069157545172,-0.13150833833582562,0.2494920427573641,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.07747947255335684,-0.02581939313644808,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12228726822136575,0.10550948554165088,0.247226159683057,-0.08521296101392371,0.3297874974566552,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08353913492032618,0.2298960263616534,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022622547663817685,0.06045193243770154,0.7084606632575596,-0.09626524497533342,0.1415103403029688,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03405879837152247,-0.05370043874539767,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06949504932290013,0.07190308440852984,0.3344451664587974,-0.07191315128485029,0.21090324993065054,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.048083511424817774,0.1103868417216854,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1294916638181751,0.11299068512806495,0.25254901894365817,-0.0927214665479143,0.3517047941842645,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.14381089946825668,0.3375811666365858,0.861510147131396,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06509577198606961,0.06574866587122301,0.3228124180880385,-0.06420884143475478,0.194400385406894,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03756719933710053,0.15935737991595295,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12937399875555225,0.1217235037923129,0.2885697703413602,-0.11001352939476608,0.3687615269058706,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.15706397856711987,0.34465302251519014,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0889089267542608,0.0750193884369312,0.23675025281180165,-0.058627953156023746,0.23644580666454534,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.051394157908544603,0.1806596141478795,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05266255794176787,0.06883200845498269,0.4447259098554204,-0.0827059111566439,0.18803102704017965,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03345478297564875,0.07829764145787771,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1949568089185425,0.2650961515306151,0.4625684283153483,-0.32639453621981407,0.7163081540568991,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09258706086162953,0.0988738380800436,0.9372011503139762,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21397625790283803,0.1825377194883878,0.24188842663526475,-0.14501154725497667,0.5729640630606527,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.28542485631975056,-0.14255853768395074,0.8491564414671808,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06112792609456357,0.0570905792982921,0.2850214975651433,-0.05114926140906272,0.17340511359818986,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04544711042068064,0.09496660839543877,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11377433446926559,0.07845548291394393,0.14788961444393203,-0.040520140627783405,0.26806880956631457,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0418779717194297,0.19823638412129982,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07011435765477637,0.07110145403751303,0.32474539335745134,-0.06971731658765219,0.20994603189720495,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06046979141143354,0.146568464516794,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07914117648363239,0.07200599704091311,0.27247089791543244,-0.06246941725210181,0.2207517702193666,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.011143734134902135,0.13796481278388445,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12186486214309566,0.11464263341182751,0.2885034943229545,-0.10359707230734555,0.3473267965935369,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.015717277809042564,0.17458789524394455,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13868736293959177,0.10893374774309263,0.20380088020359874,-0.07554719153776712,0.35292191741695067,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.024543737777131945,0.2224636899807646,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05263681588837116,0.06495017338790533,0.4182411538511208,-0.07509744229395984,0.18037107407070216,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09586022575456278,-0.04661872493501475,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09853338886086202,0.1315759185675217,0.45442946307734944,-0.16023039075994558,0.3572971684816696,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11764960455849559,0.2788425701706513,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05142113249095575,0.07928117286464609,0.5170202902859573,-0.10449718574368808,0.2073394507255996,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0201761372387788,0.09374673175831616,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04061413803970164,0.053680825496095444,0.4497985815468547,-0.0649572571651611,0.14618553324456438,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.027875267811143186,0.0788532089819403,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08897857633727099,0.0721468419663072,0.21827819244805874,-0.05290901007031512,0.2308661627448571,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.06340337112547788,0.03964603430501844,0.8330251402176395,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01370984251165103,0.04537882115377855,0.7627371278834619,-0.07553441589314568,0.10295410091644773,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.016409927584557702,0.046265684868053165,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07177229141668955,0.0769382256232636,0.3515265212973968,-0.0795382696369079,0.22308285247028697,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.006463420062626003,0.08167613162045588,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04059371376322054,0.059221968577765585,0.49350592900553836,-0.0758751704566768,0.1570625979831179,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0866731855796763,0.1476189314210396,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02604852582546321,0.057294029492892355,0.6496407285599104,-0.0866287770023995,0.13872582865332592,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06940521494916996,0.11475356601704542,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11352946156708757,0.11656538434196788,0.33074009811005445,-0.11571385099090772,0.3427727741250829,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.049809815886572475,0.17817038732618765,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13093115660183305,0.11302944530618707,0.2474850958422148,-0.09135820146837462,0.35322051467204074,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08650572036868201,0.25256668405693855,0.855600896698613,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07758101839994712,0.07516262760530562,0.30269063008142716,-0.07023756282013512,0.22539959962002937,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02667427414648754,0.12296068192910399,0.8905701340201515,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10834375122154379,0.11183714166187694,0.3333208469249498,-0.11160076289229033,0.3282882653353779,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07563038403367481,0.22099827852612183,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04691164811438794,0.060575974848438796,0.4391925569964841,-0.16604338876002153,0.07222009253124564,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05108064536068218,-0.02181377956145534,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13033385035061104,0.1093174503780247,0.23395691226478701,-0.08465531291189982,0.3453230136131219,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.029622485262915246,0.15842026204388784,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012495650661689905,0.03597074253771616,0.7285083358950913,-0.08323751130125508,0.05824620997787526,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04548229407294755,-0.010920066827241568,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010188694439162378,0.05263039238288029,0.8466076810811527,-0.09331686648862544,0.11369425536695019,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0268048329145847,-0.02787505023748792,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01925897532795354,0.04621278720879971,0.6771156684442592,-0.07162540241495735,0.11014335307086442,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04727251171568624,0.05020057736650657,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036274105738011084,0.06348671739594271,0.5681125961142248,-0.08858204672473392,0.1611302582007561,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.02385748900687745,0.0035348154663721043,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06885743826433628,0.05727341522667221,0.2300625394605436,-0.0437793235169633,0.18149420004563588,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0721121051905656,0.14989920351304148,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02736748169880073,0.05774241210118513,0.6358203588645641,-0.08619163278351405,0.1409265961811155,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04452894518449627,0.05369581608483036,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0787579575770536,0.054815010196618025,0.15165436475353583,-0.02904398196366119,0.18655989711776838,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.060477836007393766,0.12090164526729172,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034920865767951795,0.04705571318053086,0.45850551614318535,-0.05762125233322808,0.12746298386913169,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.019477550938220563,0.05255213753317385,0.9366135780422296,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06310434319372966,0.054345327605081144,0.24634942013560177,-0.04377389508058804,0.16998258146804737,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.034089199163143694,0.08886087971090288,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047900254646054706,0.07666053226103973,0.5324790158582926,-0.10286418075805479,0.1986646900501642,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06587065800819479,0.11269592521164595,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020212557293690255,0.03997176313840424,0.6134006487211556,-0.05839791049106051,0.09882302507844103,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03434530809482112,0.05353565485009428,0.9553020108982802,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027115809206197185,0.03876561491671093,0.48470829056182363,-0.10335420559653007,0.04912258718413569,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.037523386227265296,-0.02680191070958437,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07328251515665198,0.06759453624297043,0.2790326360877336,-0.05965227922193113,0.2062173095352351,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03361596409610357,0.10798130838898798,0.8744417944194353,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016113166635236764,0.03869932242547803,0.6773915154757382,-0.05999485562753035,0.09222118889800388,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09135189285107934,-0.07973554045414348,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10554317771936697,0.06487982536965364,0.10467522838523968,-0.022052730533206194,0.23313908597194014,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0031638946246393307,0.05223920600674602,0.6872720950554446,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11973855247376675,0.13512630911847676,0.3761493375403405,-0.1460076027070767,0.3854847076546102,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-9.632865955062025e-06,0.1606050864400817,0.9167557388379561,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05397185430595798,0.08720802942000207,0.5363870754528994,-0.1175358163353215,0.22547952494723744,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.021668812795849122,0.11984309237932829,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0455514728868422,0.07982829939706117,0.5686185273816438,-0.11144285174015603,0.20254579751384041,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07581056561243744,0.12951609974931394,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05789579587977568,0.09745775909292652,0.55284901370377,-0.1337695055736831,0.2495610973332345,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.15405114205696913,0.2258014686587063,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10351883000474947,0.08217332043838833,0.20858044912411008,-0.05808733024194644,0.26512499025144537,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0010666953164133767,0.0979263664243368,0.82185729615414,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032790020039323,0.12992086486756793,0.8008894877426104,-0.2227188482303952,0.2882988883090412,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.17136197032385345,0.30528383109470625,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07789410830666695,0.08073477212258093,0.3352924767151072,-0.08088293090163436,0.23667114751496826,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07143022805841892,0.16201476629187062,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011078854938772562,0.07442803962649405,0.9881320066909243,-0.14526601828119257,0.14748178926894706,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09011624870443498,0.1264519317721625,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06451200011592619,0.05565127961779276,0.24714401796214527,-0.04493458867793769,0.17395858890979005,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.01722571442188698,0.0019351290209614846,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12590315958054196,0.08199407827603758,0.12554554771962978,-0.03535049406842508,0.28715681322950903,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.025076713025220743,0.17658219558184168,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09608525213527838,0.07219200448969246,0.1840512919985259,-0.04589115314870709,0.23806165741926386,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03505151685143991,0.09837490247429699,0.8036298987262369,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07954862848021291,0.10679865376898787,0.4568558016155714,-0.13048694344319609,0.28958420040362187,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07907446290007415,0.22097374651156776,0.9353936944091839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14093644188149054,0.1047453323263264,0.1793152506246918,-0.06506096543653997,0.3469338491995211,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.016074173130068026,0.09935270099973027,0.7982357106299288,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02671504424026498,0.06835264893873262,0.6961482687848395,-0.10771069246780886,0.1611407809483388,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.012960188339088026,0.007964347853457777,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1213500466055671,0.09698336274963366,0.2116663485286566,-0.06938228328162631,0.3120823764927605,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03316230399465957,0.14060787701810326,0.8272808836142177,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018113420395044374,0.06544685599475468,0.7821209280708818,-0.1105976386336687,0.14682447942375745,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.025297040130296343,-0.035074903727144495,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0234577674054617,0.07203443230839825,0.7448830745316486,-0.11820874854893602,0.16512428335985943,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.022599475015444237,-0.03277193710551739,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027129265208449906,0.07404892018361448,0.7143070186364424,-0.11849904331609606,0.17275757373299588,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03434501210282368,-0.04203472801485124,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04633513116851599,0.054857580428466286,0.3988768435987923,-0.06155052911845935,0.15422079145549134,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11191327885688208,0.16503130602601684,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005468785747997614,0.06917324534621068,0.9370299059585456,-0.13057077688091379,0.141508348376909,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08643802905167082,0.08254876273289496,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03046368799529551,0.059086771125558,0.606470989856639,-0.08573931015586514,0.14666668614645614,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.023944885753635715,0.040019782995388435,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13095223625573726,0.10535856314178033,0.2147154069914778,-0.07625118144256943,0.33815565395404396,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08278186131081307,0.3234388637494369,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030249562671269412,0.05089514728327381,0.5526551411713527,-0.06984337848968598,0.13034250383222482,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.017859795677077673,-0.03256245356995917,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06478142574595099,0.08951347925006467,0.4697216272217545,-0.11126025779258221,0.2408231092844842,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.13631032095775505,0.24475334374235155,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042189659529164286,0.06129970038920017,0.49174214038574626,-0.07836539594774233,0.1627447150060709,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0618095595079614,0.09433369193206691,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0039947964123953515,0.053281356392554824,0.9402763164100139,-0.10079098288190196,0.10878057570669265,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11431598747045402,0.1406437888487076,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06051303884064261,0.056948671271646795,0.2886885882110791,-0.05148506524306117,0.17251114292434638,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04453434942118405,0.10134403092684688,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04630340080538388,0.0636370812820801,0.4673265315003744,-0.07884846479331324,0.17145526640408099,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04567310660030448,0.09308986085139563,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062342813935237815,0.06970289243406147,0.3717079959570736,-0.0747383791364593,0.1994240070069349,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07410102352014021,0.1797544108647103,0.915561182973695,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023170806061228236,0.058621068379290146,0.6928846984681005,-0.1384579299086711,0.09211631778621461,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04860421949400264,-0.014785154262099115,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012583599426635544,0.06502533117738309,0.8466633453778605,-0.11529846782201202,0.1404656666752831,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04462962418101533,0.05845234787021947,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008199160382250176,0.04971455402289728,0.869096818698705,-0.08957196704883862,0.10597028781333896,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05404408718632822,0.02803738455255709,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07389175915461724,0.05745287838433087,0.19923421364462351,-0.03909794384483245,0.18688146215406692,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02394842614245364,0.1234226818050855,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025429435338490906,0.05541049367728734,0.6465658315886273,-0.08354361178663093,0.13440248246361275,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0426187035959815,0.0757380042588698,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09378933114906315,0.14675133011711108,0.5231664060215311,-0.19481917152308184,0.3823978338212082,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.12734773802759783,0.25204289763814525,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008137267196383507,0.08155347631371626,0.9205764997325938,-0.152249876605494,0.168524410998261,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0679247884347943,0.15897930060017637,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08849770966853401,0.08449098938050904,0.2956156506498177,-0.07766649419208618,0.25466191352915424,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07800414708547647,0.191066290238384,0.8831753988928314,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04465801980339201,0.05369251022901134,0.40611524183154535,-0.060936355181403834,0.15025239478818786,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03054157835994755,-0.0024882723390311605,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0417448133100391,0.08748899766420934,0.633552662758732,-0.13031542352736528,0.21380505014744347,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09245524120485085,0.19206472368235897,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027073724905524715,0.07320101588360406,0.7117108284498921,-0.11688705263146569,0.1710345024425151,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05844735930273761,0.07999934088816324,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10854959981805024,0.0737927753033996,0.14217288439964207,-0.036574961379047616,0.25367416101514806,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03397967551094342,0.19417672668886982,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008642057141583535,0.06128429362826688,0.8879371743815071,-0.1118826986290074,0.12916681291217447,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04198692811769382,0.04419769486587198,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09410668610847017,0.08853860471185517,0.2885528662992401,-0.08001776042416117,0.26823113264110154,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09670048403754271,0.25868099359520746,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007173552896425112,0.0485281595520034,0.8825665547333594,-0.10261145764701113,0.0882643518541609,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.06330904474028691,-0.08323041200154499,0.9870366109823806,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06761032946433919,0.0757908075082578,0.37296063041995,-0.08144366175887612,0.21666432068755448,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09127848749121599,-0.016968236881950607,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05410304443654482,0.0866761318430425,0.5328975278884818,-0.11635856983755394,0.22456465871064357,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09400013161237682,0.17858566206043064,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0584373711861048,0.08508593140463241,0.4926532728359535,-0.10889687540340894,0.22577161777561855,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.058355298739412566,0.16187981630228465,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021194374437144402,0.044879884249920426,0.6370401014986231,-0.06706864970806871,0.10945739858235752,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.030426752815497924,-0.027869085286112222,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055569907717496245,0.05112155603265487,0.27776552534982446,-0.044968300209345335,0.15610811564433782,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05711281386629223,0.07437994127261469,0.873574778219852,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018833811610988346,0.061745325064624476,0.7605260558274015,-0.14026525485368443,0.10259763163170775,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.017463384421257333,-0.004526366390479411,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050900669133235224,0.05377937605946499,0.34454991194828677,-0.05486454053660636,0.1566658788030768,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.01392787419286764,-0.021293109886007553,0.906241617311299,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051534189683378695,0.11087604042392592,0.6423652517748217,-0.16652017468544095,0.26958855405219834,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.12457495227008879,-0.07340274205628641,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03727632517267339,0.05821675221429319,0.5223879256807697,-0.07721565029081412,0.1517683006361609,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.012471579103875318,0.01853096959332088,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1126920333391629,0.10170056548363254,0.2685767303831013,-0.08731738328226259,0.3127014499605884,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.13287956061624007,0.0043941049938629375,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051183286640096456,0.04684086058436901,0.2752618125932709,-0.04093629160387047,0.14330286488406338,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.00019677761989330992,-0.026982998210579402,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05331236248978705,0.09712417509658919,0.5834117981616116,-0.13769689599887222,0.2443216209784463,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.11800932943850141,-0.04167598287066515,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0351836600425976,0.046286510774404356,0.44768134225171674,-0.05584570615025666,0.12621302623545186,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03937821221653856,0.032084364112946726,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018628526781743523,0.042157801014308785,0.6588471251810446,-0.06428111238118778,0.10153816594467482,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.006195341760565475,-0.024901049201293463,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023740832955115806,0.05546239006810674,0.6688714983186359,-0.08533427620676251,0.13281594211699413,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04540500613777188,0.052419175517108695,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054489360365878974,0.06274972398187437,0.38578219972847483,-0.06891738400261738,0.17789610473437534,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04615497646621238,0.0866650307247003,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13700783681045045,0.10391150672253684,0.18818228271013585,-0.06734972738787981,0.3413654010087807,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03317438253822294,0.18415356837527502,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012731014780617656,0.09374950566837036,0.8920575624326637,-0.17164145009319354,0.19710347965442887,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08869530116170855,0.14307990844850202,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014235347473957969,0.0527043070946405,0.7872410810429498,-0.11788627276927509,0.08941557782135916,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03586552163909907,-0.09146836846443399,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04029888635131286,0.07090340511377453,0.5701466986697548,-0.09914329497619369,0.17974106767881942,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06096585657575051,0.13288206866327484,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03493384297051908,0.0636775273575498,0.5836200752866121,-0.09029756590230689,0.16016525184334504,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.033482610777307194,0.03626861157273166,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019996920070156098,0.0732885752616963,0.7851253378171741,-0.12413605611734016,0.16412989625765237,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06402613189244075,0.1271708402122698,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05093640071421508,0.06770488561585225,0.45234991351490483,-0.08221541225801769,0.18408821368644784,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03928613703106963,0.08254006589144516,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035429163775952156,0.0752505932196956,0.6380606697937918,-0.11256241501924893,0.18342074257115323,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05879408198617218,0.10214940955606491,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09893347870231022,0.0876646856076076,0.2598500702606555,-0.0734722748281371,0.2713392322327575,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0472441504767314,0.04858363249418512,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06899782931733281,0.11339905264873042,0.5432760408681854,-0.154018417031318,0.2920140756659836,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.1283902989948482,0.2407670665140441,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07468620211344831,0.0867249635238639,0.38971603752599115,-0.09587144698550404,0.24524385121240067,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03241303967060252,0.14637735904045374,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09820378704024303,0.1198323794000678,0.4130440187201606,-0.13746456133312152,0.33387213541360755,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09737894964106732,0.24701583252188844,0.9263451842579509,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12948546304382144,0.09174953431265251,0.1590316110309353,-0.05095375817284348,0.30992468426048636,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.010105474729309557,0.12992926846668312,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02249636413256217,0.08755378805915871,0.7973709354925395,-0.14969129273475917,0.19468402099988352,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09332747853736746,0.1855938639305858,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03415655624114628,0.06830211456773269,0.6173273582155616,-0.10016979704644252,0.16848290952873507,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0196602254997561,0.026491072833083586,0.9570174945596325,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.092435708351975,0.08218205897255458,0.26144535228566973,-0.06918763753289713,0.2540590542368471,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.13589509324233953,-0.04077233695891532,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025810791690085752,0.07883668857594739,0.7435610636506677,-0.18085496490048858,0.12923338152031705,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.10904986625750444,-0.03548578921224342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0487171432247214,0.0596531124609975,0.4146609322701583,-0.0685996501110696,0.1660339365605124,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0075511853824476805,0.06147101665362238,0.9266831307321275,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09044409032964777,0.09666437093629202,0.3500872844949018,-0.09966089430936469,0.2805490749686602,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.1244755721547472,0.2890714509090745,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015217487871672248,0.05388757891387285,0.7778061066338662,-0.09076051894127246,0.12119549468461696,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0641183071672962,-0.06914455809787261,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030035009086584758,0.043925772274425554,0.4945668952406176,-0.05635161074658983,0.11642162891975934,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.019824604304632187,0.014762109042817145,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005636963405394293,0.06411086065418456,0.9299855256883794,-0.13172058720397212,0.12044666039318352,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05536742049939218,0.08648945780488217,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0169920318920318,0.05303758843608224,0.7488704012275147,-0.08731434115183591,0.12129840493589951,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02524663046584581,0.021748206882381778,0.9640825891897521,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010343927540207723,0.06230223998330518,0.8682290227865178,-0.13287062750506062,0.11218277242464518,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.037081936534998534,0.04925588873444325,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006535776830013011,0.04093500344407319,0.8732376463880248,-0.07396904749726944,0.08704060115729546,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.022292351351684413,-0.014466274846595397,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022366901174004954,0.0626163486156222,0.7211496572665018,-0.10077754053109018,0.1455113428791001,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06535434018047122,0.06973311952601073,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1407554866472119,0.10021237056064371,0.1610204788856333,-0.05632717143604335,0.33783814473046714,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08959661674338552,0.28402818522124623,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09318778135036355,0.09553266015670854,0.3299971208617235,-0.09469152428939988,0.281067086990127,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04448965862104119,0.15491322513526318,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050286543179385475,0.03765938613115393,0.18263164881187213,-0.023776288375128553,0.12434937473389951,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0133369195748903,0.04186672904799102,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13414478822726422,0.10769014918791021,0.2137102192905846,-0.07764404315749976,0.3459336196120282,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05929324423821548,0.25511171783218456,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05638579645082731,0.05942538518385569,0.3433404015434002,-0.060483137036463144,0.17325472993811775,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.028697226970109357,0.09053565361607366,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08523937874901612,0.07608182434752696,0.2633136889411353,-0.06438694073975444,0.2348656982377867,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.04518347645579653,0.04227585673549496,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06116382100844584,0.09447416739902925,0.5177818253832702,-0.12463379985449588,0.24696144187138755,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11257590550061929,0.19700085001872342,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09791837192346077,0.09742322998585201,0.3155398405358363,-0.09367902286173528,0.2895157667086568,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.06631193602329225,0.08160679877753345,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09776200435916331,0.0980850952814533,0.31958420520265685,-0.09513704780645792,0.2906610565247845,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.013325260889999392,0.11776665386314404,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0914869329346783,0.09230455738515875,0.32228937328895535,-0.09004382440487346,0.27301769027423006,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.024867740173121197,0.16687524877963308,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02291359132710601,0.08301231303438672,0.7826879397545823,-0.14034257370449288,0.18616975635870492,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09603512057487874,0.18135345784842824,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08609422321260311,0.07630418289769704,0.2599518627535607,-0.06396939771779474,0.23615784414300095,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.050855110654302704,0.05920229753999989,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11473905802813723,0.18378744577952585,0.5328284659307264,-0.4761846373904347,0.24670652133416027,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.16352558130836725,-0.024002458985077624,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02450478564138044,0.06427149630850576,0.7032304427067949,-0.15090432354875993,0.10189475226599905,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.10180671905093641,0.10738511137629281,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010775603324491219,0.06006592812279635,0.8577286216579503,-0.12890426057958226,0.10735305393059984,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.10451050293302949,0.10324289997484068,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07348073288897121,0.06753466078691528,0.277311408122682,-0.05933630742424774,0.20629777320219017,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0695044761576531,-0.027165812910448166,0.8731844338269933,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0032396245226133887,0.05464852150743605,0.9527614762435944,-0.11071413908354563,0.10423489003831884,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0628212609397157,0.060117194956986864,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08268265946471053,0.07023748323495899,0.23990726465004603,-0.055449886603011964,0.220815205532433,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.02767538439494188,0.03446532875820252,0.8466912699522725,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08168614436233024,0.0734165640360679,0.26661418064531145,-0.0626985409476711,0.22607082967233158,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0522989984772505,0.0010085794725044103,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06412148294922974,0.07264759253336675,0.3780278077768886,-0.07875090455866636,0.20699387045712586,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06971517544483788,0.16582726911967854,0.9171668992289758,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010315492073273395,0.04399515060749909,0.8147558094129546,-0.09683855480485486,0.07620757065830806,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0745515088150061,0.014843521871435797,0.9770888048613304,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06271936922339541,0.06182815871891985,0.3110740263760269,-0.05887497882512406,0.18431371727191487,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07231569183458465,0.1268587203093154,0.8977920836150588,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09631717281039884,0.07212191785991945,0.18257345312273263,-0.04552139660347915,0.23815574222427682,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.04987828370326496,0.04510003298366261,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1391713788182462,0.12351505413508261,0.2606044038605756,-0.10373950180510191,0.38208225944159435,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07445822220275536,0.2652329468605589,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10488971250241207,0.07910689375445619,0.18571505664563157,-0.05068585972101129,0.2604652847258354,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.024094171696946175,0.08428945769246085,0.8073060060237306,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06385261140616205,0.08936902713871377,0.47539705853439396,-0.11190498538827454,0.23961020820059864,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0410167209602422,0.10213077839061473,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17384815002249587,0.0875438886851487,0.04781777963765027,0.0016799617590239346,0.3460163382859678,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.031321629387063815,0.23611022331917772,0.518548544759109,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02699949636262879,0.05070736268034497,0.5947415983589681,-0.07272413820987575,0.12672313093513332,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06203228308051085,0.08459095047183914,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07553800001962148,0.1484769300802236,0.6112409057280241,-0.2164641538117163,0.36754015385095923,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.157376951815049,-0.04514545585337722,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07583246399219935,0.10824521401821693,0.4840341146657694,-0.13704798563842957,0.2887129136228283,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11378331189051924,0.21952189459562224,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031117912425513473,0.05130002870393181,0.5445118831019653,-0.06977128877944035,0.1320071136304673,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04152275312693831,0.03691413257976592,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0333303909375325,0.05820588679284228,0.5672572411822434,-0.08114021604491062,0.1478009979199756,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.049064369892676825,0.04667908294086083,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04534217606475854,0.050973408302989846,0.3743210993983025,-0.05490467713024668,0.14558902925976375,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.031232344260220132,-0.012836350763482269,0.9159127256227925,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005013155295251126,0.05284868504154261,0.9244804642544624,-0.10894802147915196,0.09892171088864972,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03084846354136358,0.003476894880723816,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022954576694875238,0.0723241920913175,0.751137938147195,-0.11928179533521319,0.16519094872496368,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.009933424208461567,-0.06144180435775889,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044856796431189755,0.05220169209170613,0.39075450830550673,-0.05780566107101309,0.1475192539333926,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.042535783916034124,0.05736317115555991,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023698214558673273,0.057605501629319794,0.6810355685173042,-0.0895916449448031,0.13698807406214963,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04291677866268568,-0.0036942521513758124,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028560125104768363,0.06273549137262746,0.6492092865891486,-0.0948186287028207,0.15193887891235744,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03989384021012403,0.04840694706406599,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023710007826163705,0.04905917726165021,0.6291840718439268,-0.0727722229005566,0.120192238552884,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.032775890269523406,0.02476230862999215,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010378343933492058,0.05951776194509743,0.8616707492322668,-0.12742895017783626,0.10667226231085215,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06617996095084552,0.03126942863100614,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017684193970986316,0.04201891029836876,0.674109263502662,-0.06495229576610657,0.10032068370807921,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02057036251561928,-0.0011097557321781124,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059520974770167885,0.051271679105265644,0.24646292577915638,-0.041312472696704856,0.16035442223704063,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04836248843465225,0.08159409637570099,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004762388079114381,0.07689485963466168,0.9506503357468736,-0.14646288725320672,0.1559876634114355,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.051263357310323034,-0.08177287568082826,0.9938446417962179,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010120777707949388,0.05024203757865689,0.8404692525635473,-0.08868772525554834,0.10892928067144712,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.005471778763360378,-0.009696512873396896,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02291655101689624,0.05715559793735462,0.6886972919149253,-0.1353216074267235,0.08948850539293103,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.047888205657375844,0.005023811038713091,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04038518822285333,0.07037753345558226,0.5664408872937058,-0.09802278761058733,0.178793164056294,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04271045462546118,0.05849922109667781,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009233706345172368,0.05773942615465439,0.8730345540676834,-0.10431953582541202,0.12278694851575676,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03245729356093741,0.006583895564791285,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05058692886559481,0.052646641814858924,0.3372663544490312,-0.052950589007515994,0.15412444673870562,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.023152634641798887,0.05594290126898236,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02541454858377947,0.052458905482835536,0.6283532134684222,-0.07775375763285644,0.1285828548004154,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.053917833006453246,0.07968435561458498,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029129475659001963,0.06547763518539212,0.6566792039415403,-0.09964211526483087,0.1579010665828348,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.056636371203747954,0.08090299710649836,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036197661374920156,0.06311681808407354,0.5666665226073209,-0.0879310286079085,0.1603263513577488,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.054713293523917246,-0.06508730294379593,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052667973939813185,0.06258938396499623,0.4005758067383568,-0.1757104367422176,0.07037448886259123,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.050243550480914535,0.07514719140633198,0.9219399112464703,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039373143727224946,0.08593550997963872,0.6470766698630463,-0.1295647195370758,0.2083110069915257,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.001557109442987959,0.11580614036897836,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014350257495960977,0.04667533773205263,0.758660918382076,-0.07740729215331515,0.1061078071452371,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.04486795797319836,0.020108598054144465,0.9669637716950737,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003851456276579898,0.07916309593529798,0.9612205968530116,-0.15947564795083422,0.1517727353976744,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.14033408662009647,0.22013434063908607,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014077803305938654,0.055388072851956606,0.7994964125675541,-0.09480783291305887,0.12296343952493617,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07597547753172064,0.10204871076474344,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023815937692101392,0.060290021741339184,0.6930350004135235,-0.14233815803562808,0.0947062826514253,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.058938496515559054,-0.024924868491415234,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0464238345073388,0.06190534305018719,0.45374259389072114,-0.07527389419666347,0.16812156321134109,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0746542563145325,0.15734005060547562,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001601361255550971,0.05231153633089535,0.9755941185816877,-0.101236210475951,0.10443893298705292,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.017727182593728533,0.017373172390622988,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00012146613346779615,0.04342158148445829,0.9977694105153092,-0.08523962845105457,0.08548256071799015,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04667944583595892,0.06213522294208008,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04319626352114064,0.07384118717201567,0.5588826634607991,-0.10196575837987915,0.18835828542216043,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.1252466320807649,0.22029068602757482,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020711580329338414,0.04598776991376964,0.6526847854067153,-0.0696943017950979,0.11111746245377473,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04307002589058615,0.14379664783288212,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06984682788436299,0.07745939087194251,0.36774321341239,-0.0824281046407452,0.22212176040947118,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.13436423516644128,0.2413819266466828,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027308323887409867,0.062419488533682815,0.6619854887469027,-0.09540014693483109,0.15001679470965082,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.047985618323336185,0.13127589348042298,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01951979415239833,0.053429061734258085,0.7150490018385327,-0.0855146849324481,0.12455427323724477,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03190663095428254,0.07978666686741846,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060904457650084724,0.12322682824448696,0.621401230441148,-0.1813432123223525,0.30315212762252197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.05606131687352582,0.036911738736822124,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016041028827089753,0.10013902763914738,0.8728135699515157,-0.2129011319757257,0.1808190743215462,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.22994005158404654,-0.19609521203333208,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04784083655604508,0.04377427716554969,0.27509128890079804,-0.038213611157588256,0.13389528426967842,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.036964466571626574,0.0809771715935344,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006799536336249165,0.048475359486760024,0.988815549998789,-0.0946162010596147,0.09597610832686453,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04438164629202526,0.11707817461473458,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019477108680632366,0.053399461521482186,0.7154941767647933,-0.08549918029514607,0.1244533976564108,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.053259466051061834,0.09626750984177686,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024051745867436275,0.04642339570133754,0.6046760477319173,-0.11531401075787917,0.06721051902300662,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.019871613434344182,0.07022609166511884,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0391646248906291,0.07489499991663981,0.6013123619485021,-0.10806905369107683,0.18639830347233505,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01600278604786314,0.10871236850854371,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011361471017736421,0.06876262297474899,0.8688478304347562,-0.12381676438873536,0.14653970642420822,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.022616725927612834,0.11894600015186417,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021267321739875708,0.043088494050481436,0.6218765720101583,-0.10597361041948669,0.06343896693973528,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.07637323928065758,-0.05970001795938837,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015718068810405222,0.08113472511134251,0.9845532957048702,-0.16107196112570882,0.15792834736362776,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10928393873049912,0.17438142975306334,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015176491261540474,0.0466379796371633,0.7450392413495579,-0.1068605998300838,0.07650761730700285,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02111564337810089,0.0596433678811247,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06868090167366075,0.04436747252703466,0.12240690780677416,-0.018539689778356266,0.15590149312567778,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03549714345947431,0.15058501671964866,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01850023958546951,0.041817729724792106,0.6584358001508133,-0.10070837342844403,0.06370789425750502,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.050949529305168065,-0.012891018603788142,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04326702640886029,0.044422350431535106,0.3306446277314965,-0.044061447755773725,0.1305955005734943,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.027626686940126512,0.12769651479995722,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024307118224741447,0.05199281259810614,0.6403883029824302,-0.0779038847413946,0.1265181211908775,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0014217790871333276,0.07288050905865233,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002059146641041872,0.04062102041679371,0.995957916966691,-0.08006147605490324,0.07964964672669486,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08094108990252623,0.11143238498946481,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032665088653217926,0.050247513827524286,0.5160085679904886,-0.06611488742857463,0.13144506473501047,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06687156248613638,0.1377080820186335,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05759700091966186,0.06746836153384511,0.3937844414900964,-0.07503688742488546,0.19023088926420917,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.033783731941160834,0.11362209496062947,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039889006656112204,0.07107770997583493,0.5749712400957652,-0.09984038404491807,0.17961839735714247,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07155540149543617,0.1516769139276965,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018821192221839724,0.04541870684106289,0.6788068252747081,-0.0704659870568408,0.10810837150052026,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.025245206901736362,0.07902778585088364,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017074309630884764,0.06664243545771767,0.7979211432011757,-0.11393591712663875,0.1480845363884083,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06203757920960184,0.12093298210564347,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018541064773188478,0.054957889896665696,0.7360147170572979,-0.08949888856923348,0.12658101811561043,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04456906205696371,0.07016710246995803,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011923688309521955,0.07167744809676806,0.8679633577935595,-0.12898470833087605,0.15283208494991996,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.023841968520795925,0.06875487513384747,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008773368812993444,0.05267444170327646,0.8678010910778322,-0.11232436457830547,0.09477762695231859,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04616461577201218,0.049108077802067586,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005087190280549943,0.031790437976236936,0.8729434033625387,-0.05740861227201818,0.06758299283311806,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.014932989793278145,0.01672882783766496,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-8.810346536002999e-05,0.0392259409425073,0.9982090234359138,-0.0772011228554696,0.07702491592474953,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.048847552322779646,0.0663991073493297,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006753748773970296,0.03580275786509757,0.8504717636924948,-0.06362974477987977,0.07713724232782036,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.013865048014585967,0.016994640387167474,0.9832573347205102,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018117010033921823,0.04820025673703162,0.7072116363250298,-0.07663832898570089,0.11287234905354454,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06670056662281067,0.10494455435168569,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011857496615880739,0.03604989951501739,0.7423877775513178,-0.08272683801389863,0.05901184478213715,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04019084020290109,0.03566853987692001,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04830082151803327,0.04972107242670411,0.3319140736331653,-0.04944424029596128,0.1460458833320278,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06014898925404264,0.1324437186405715,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0024036986845543374,0.03566235507443257,0.9462954467335811,-0.06770378152560452,0.0725111788947132,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.020384450499025434,0.039743041009026446,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0074653264034370125,0.042495698044016886,0.8606394593783512,-0.07607560361701829,0.09100625642389232,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03195629882470342,0.0568577424735288,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03066703859906732,0.05661301202086192,0.5883273415450813,-0.08062666625037929,0.14196074344851392,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06194871980437872,0.10673330630324522,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044256734048316385,0.03417456667074906,0.19605486944296757,-0.022925950649867854,0.11143941874650062,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.028555351326954845,0.07499390891621983,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0314485705792038,0.03289256837748342,0.3395951058396677,-0.03321387478573982,0.09611101594414742,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.034012372968550565,0.03988724753740743,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030236393409148823,0.043427723429782815,0.4866759253854531,-0.05513677542872536,0.11560956224702301,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.030363899622486996,0.09424774910353606,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01664298116665619,0.035287062375089086,0.6374351482340539,-0.05272672316085762,0.08601268549417,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.08220335249564889,-0.039679436252223275,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02585784076695115,0.03253095704008727,0.4271577240244935,-0.03809372446606185,0.08980940599996415,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.021680450052766677,0.0768969850041249,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04757553481185024,0.06337847519180471,0.453296801697481,-0.07701817712853236,0.17216924675223283,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0011546758493428543,0.10464503601527919,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02600674275608787,0.05621828735780608,0.643898702397786,-0.13652447104857712,0.08451098553640138,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.031101190590124835,0.07509153812533002,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019289966187608743,0.047375375665450054,0.6840972306486247,-0.07384376558591542,0.1124236979611329,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06556318772455294,0.11048652547473276,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04855281106415805,0.07444578451620308,0.5146502844846574,-0.09779776936739812,0.1949033914957142,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.135080284325875,0.21698924086544516,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01192379546199254,0.05438075186491845,0.8265546347397962,-0.09498158073164603,0.11882917165563112,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.011072304985834154,0.05778988856760394,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009943410289189464,0.07274597974442798,0.8913466737726615,-0.15295239902974167,0.13306557845136274,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.15116600732193614,0.2177007701321216,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01991248709833509,0.04687503697469353,0.6712096302642311,-0.07223764488803597,0.11206261908470616,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06623912498713068,0.11113800912708384,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034362899517455914,0.056450614111349474,0.5430496978377373,-0.07661155248950308,0.1453373515244149,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08152834765858495,0.14717538464980048,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020941775152054264,0.03522547238046642,0.5525069517544617,-0.04830685138011653,0.09019040168422507,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.001533842476014027,0.036472648111969354,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012114844745684791,0.044797033668728614,0.7869613315355789,-0.07595020717949803,0.10017989667086762,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02523102669287006,0.05214995353123866,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0032432876432340963,0.0516447784355679,0.949956969565402,-0.09828352612362773,0.10477010141009593,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.034426357193109075,0.05412782780723958,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03419881853823444,0.06089617812351064,0.5747060641139443,-0.15391266227507466,0.08551502519860577,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07232912693770366,0.09782940734674819,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009466509914177974,0.056035341792182135,0.8659300094506517,-0.11962459138595816,0.10069157155760222,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.00655066124961964,0.00601572140472284,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00824672738232836,0.04889256576239264,0.8661405441121023,-0.1043630545137432,0.08786959974908648,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.004176575072564759,0.03909846057984531,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002380681407646512,0.053541008859651115,0.9645560647207927,-0.10763523375635045,0.10287387094105743,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.029237694246456926,0.037614249852087805,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008680388335838693,0.04936676219525839,0.860512149814819,-0.10572892302795658,0.08836814635627921,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.006636972242339446,0.04263434676602632,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011672498208333779,0.04764119577270095,0.8065745540299155,-0.0819838007896392,0.10532879720630677,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.01611341922093322,0.02221794369299566,0.9740740620552973,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027127702359946146,0.04489784234016447,0.5460443572708698,-0.11539093081954323,0.061135526099650936,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.020036586411164077,-0.00555212168043075,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03732857917707852,0.042875258301180816,0.3844733333955266,-0.046958516181087775,0.12161567453524481,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10270655537610925,0.15252139194399278,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029009041706671002,0.052557377737419086,0.5812885907009693,-0.07431182176220297,0.13232990517554497,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07928827104676078,0.125242733010549,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05430242044377221,0.043880971319586154,0.21662442261757017,-0.031961773885782564,0.140566614773327,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02297224547904552,0.09374194848388251,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04331937988037021,0.07400119337536665,0.5586147750563419,-0.10215719308469226,0.18879595284543269,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07747165309388754,0.2216405580911427,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003406599540382728,0.03691206999271915,0.926513823870556,-0.07597085423218344,0.06915765515141797,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.011065269194320661,-0.00278104786085086,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05108052526155118,0.06393838984557709,0.4248176519961908,-0.07461390494117826,0.17677495546428063,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.12111978115751339,0.20931713769348506,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032772975063186674,0.048253179322961366,0.49740870188245645,-0.06208640277097861,0.12763235289735197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05668914523859328,0.0951816428686581,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014656815445246343,0.04682055614319648,0.7544104509893097,-0.07738621442159167,0.10669984531208436,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10272786101414401,0.13683743452629116,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005099511805562987,0.04063822788176221,0.900201710842025,-0.07478987718880369,0.08498890079992967,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04685776705370141,0.07590595776467465,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015800802948033838,0.03676844245771117,0.6676157964988023,-0.05648109897858383,0.0880827048746515,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04050194088497707,0.06470688470906248,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04235888814041255,0.0556630667352879,0.4471096741122228,-0.06706734973524295,0.15178512601606803,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06909506652175945,0.16023306696557962,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03596423788400662,0.057540787063738295,0.5323105753355533,-0.07715335017007352,0.14908182593808675,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.044935510644274076,0.06188921258993402,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04130029071579238,0.047786033325757496,0.3879507724168687,-0.052640739783042116,0.13524132121462687,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.041360652071613664,0.09543158190190551,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02109800621093996,0.04824408367873678,0.6621149967587266,-0.07374349078792594,0.11593950320980587,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04462888010747717,0.052597108654562415,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014853958887206756,0.035044101894877756,0.6718906121016496,-0.05403811722358623,0.08374603499799974,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.023346149615589184,0.08726890938549647,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023511816968703834,0.04122006539540262,0.568726086375005,-0.05752138773519566,0.10454502167260332,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.039497371242605314,0.08480988331467573,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04814824156696363,0.09497128601784305,0.6124483608855874,-0.138552764048976,0.23484924718290326,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10284936618873629,0.13815329333071255,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06454554168551564,0.043218212931880905,0.13609404764271824,-0.14950684055420743,0.020415757183176134,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05975589560613498,0.0776737970868283,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01239635707205077,0.05611723467060133,0.8252813395650507,-0.09792271498324932,0.12271542912735085,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06693008004106261,0.11803621208088648,0.980554299276661,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010206708340717562,0.03275694671653068,0.755513928509613,-0.05418912275011353,0.07460253943154865,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.023252653613465984,0.006701615889694628,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04532149377203358,0.06685094752943657,0.4981934529348844,-0.08609864018065701,0.17674162772472418,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0791656315258166,0.17014699597139982,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037232932569345185,0.05373754332629659,0.4887925406412127,-0.06840798058481326,0.14287384572350362,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.050800322153762394,0.10163894923925998,0.9408426740082313,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040420093799258296,0.04568083418851494,0.37677214567821327,-0.049382393225803005,0.1302225808243196,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03981315289403399,0.14388042307004567,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004805706208870501,0.04583147779631352,0.9165422266925745,-0.08529292625387944,0.09490433867162043,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03626720655044344,0.060003353053178006,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00010587668462045514,0.05309253392374916,0.9984098531250981,-0.10426703316941718,0.10447878653865808,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09025651706618346,0.16314940000009095,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02453148711817832,0.03632484858220516,0.4998494536365752,-0.0959413420702348,0.046878367833878165,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.03551305013957142,0.0032910255064567276,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003082620019978909,0.039787504284415784,0.9382824676789481,-0.07513435873561364,0.08129959877557147,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.06619880756899796,0.003949454769667074,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020521046391184298,0.06875619315721236,0.7655051185606689,-0.11464454884318548,0.15568664162555407,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08447568989723384,0.1434842578219763,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0018659704292533694,0.047960968563373174,0.9689845821860873,-0.09241895964333624,0.09615090050184297,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.055582048449694534,0.109243442141093,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028979756849577258,0.04126880045756916,0.48294765549856566,-0.11010876824933993,0.052149254550185424,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.010359625353158802,0.007473545330928039,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030630860068195546,0.04284675209200203,0.47508883808019653,-0.0536001958474915,0.11486191598388258,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05602281884481476,0.07970962610757874,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020607408673476785,0.031745058820336056,0.5166090903545356,-0.0830140017986912,0.04179918445173762,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01698888644694714,0.008582048028515601,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00853772839464855,0.04444334964972361,0.847757798831833,-0.07883202745961328,0.09590748424891037,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0004120043581228993,0.009172132318551547,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061140071279218035,0.062085919855954005,0.32533012077105894,-0.18319279013488832,0.06091264757645224,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.10149910951390852,-0.09702938676273394,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02028582994725927,0.04459873761860175,0.6494605588854931,-0.06738939813199396,0.10796105802651251,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02120797792116819,0.05509467169391549,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043145776377564775,0.05645458165063863,0.44516169208236,-0.15412802804278014,0.06783647528765058,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.10227472588387865,-0.0465393537190088,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006252150719196767,0.04425885129732883,0.8877325385857877,-0.08075490574063843,0.09325920717903197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.012887384664265861,-0.001887026423648075,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041177623513438275,0.060272716378898236,0.4948803416341184,-0.15966582379989563,0.0773105767730191,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.09616662223314648,-0.05339383275766096,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03023474585071078,0.04064391531593106,0.4573743818095872,-0.049665823888102166,0.11013531558952372,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.032626447822361314,0.0426831985888557,0.9362139873142092,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044976144850677836,0.03475898460074197,0.19642615908965444,-0.023355428314797068,0.11330771801615275,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01396529768195864,0.045433517164302537,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04167882589920513,0.04337366071295464,0.3371661637507516,-0.043588062777355316,0.1269457145757656,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03921902930042358,0.08332345204972365,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02348564692604167,0.04698099572060931,0.6174206167245145,-0.06887278596100967,0.11584407981309301,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.045111213338412844,0.09244716561549034,0.9570174945596325,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010490349558143522,0.05743348456263571,0.8551628090901902,-0.12339699506631358,0.10241629595002652,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03809442918140002,0.0866532794012141,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017527431677299508,0.058333085456104404,0.763972447958355,-0.13220257373327926,0.09714771037868024,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09105410269863688,0.13407487561875872,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01240974978894899,0.03274086126108275,0.7048656312960232,-0.076773958998748,0.05195445942085003,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.02273638988174232,-0.016841400935344378,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03523383111247017,0.04603597490917617,0.44450858276615957,-0.05526681566658417,0.1257344778915245,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05370134648149714,0.1315728206805554,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02331801821390751,0.0476660738126337,0.624969590278745,-0.07038718772497311,0.11702322415278814,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.029305138811762377,0.08420675571354846,0.9595394253172342,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02793217512279121,0.053907323429015996,0.6046367266907186,-0.07804250329074609,0.13390685353632853,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06528470375901906,0.15338585833125795,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019886507142061978,0.05063941358391172,0.6947427291859682,-0.07966389210325844,0.11943690638738239,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.034329938183146204,0.07942953672957813,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0061992682029154275,0.05380629980404983,0.9083324563362247,-0.09957681110595558,0.11197534751178644,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.056810520487584705,0.09683116223061956,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03507221463586961,0.041098272461677646,0.3939586253362827,-0.11586599051705003,0.04572156124531081,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.02562614336796799,-0.008135183507594257,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0038477769816789333,0.07010683591370978,0.95625769753917,-0.13397300353488842,0.14166855749824628,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.11672174902395578,0.16906938498760482,0.9956418681880812,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004242341885330039,0.050400457299415516,0.9932882357243373,-0.09865640856001523,0.09950487693708124,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.030830830866331753,0.09402235161315257,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011019311503563948,0.07224689773152061,0.8788508063491673,-0.1310085479125193,0.1530471709196472,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09247993653342881,0.15652208374211582,0.986191362849829,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023345725287783073,0.05064250087294173,0.6450539124521908,-0.07621074316003737,0.12290219373560352,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.008482999352326642,0.05971768900256882,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0037180175994914015,0.05580441985302583,0.9469125964011637,-0.11342213703635544,0.10598610183737263,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09225591192534872,0.16303807589829544,0.9933384683801291,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007623145622169107,0.04932895129824981,0.8772637432779989,-0.10459734908438857,0.08935105784005036,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.022069674733858628,0.045562927463901406,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01753446117245943,0.03674919746348512,0.6335220607975295,-0.0897785299820821,0.05470960763716325,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.10686590680721145,-0.05899279951905918,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028672552502013435,0.06385039524600979,0.653630956039414,-0.09684889193926279,0.15419399694328967,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09168356231168638,0.06501295443826015,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003964608434709848,0.049267379549525134,0.9359023943926925,-0.10081776997061204,0.09288855310119234,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.010351096589851687,0.05263637330890759,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012935788830548578,0.06509890095161516,0.8425899740599183,-0.14091163060103404,0.11504005293993688,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.11555799939301703,0.18848276574494433,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010753113358885277,0.02990110510773381,0.7193177444082308,-0.06953473701293339,0.04802851029516283,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.05666867620561762,-0.07627183804124502,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018487270325866337,0.03931963766990079,0.6384814305186097,-0.05880994445593246,0.09578448510766513,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.023607649907223104,0.041740175986440954,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014691167319721378,0.03315465757280007,0.6579237850187465,-0.050486510789543484,0.07986884542898624,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0490203030358491,0.1011182623182704,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024626032409955503,0.04859919716429227,0.6126306229419736,-0.07091357080228246,0.12016563562219347,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.027257080405057765,0.05236236871951832,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0014974513073059148,0.03502464267684774,0.9659186316693512,-0.06735637055078567,0.0703512731653975,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.033822642476099195,0.07591469717031785,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04884829924947298,0.03635267309098285,0.1797906883508391,-0.022616255012105208,0.12031285351105117,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0230130964485374,0.07833469787376147,0.7995397670190257,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038487790770219264,0.04588583128421136,0.4020940109238441,-0.05171769347136574,0.12869327501180428,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06450163341154508,0.10342823988923733,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026845521648113588,0.06747933319668971,0.6909637660163993,-0.10580993553657746,0.15950097883280462,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08142829202825957,0.16663998230048874,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017660980807222566,0.05131787520601501,0.7309139493918246,-0.11854514599833324,0.0832231843838881,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.039229965602519436,0.056759557127808245,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035800203187149895,0.043573554792594005,0.41178814937059705,-0.04985965085031269,0.12146005722461248,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.013135548631129824,0.0501362124951342,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03447777754972815,0.06679935469283212,0.6060401360512199,-0.09684093169997567,0.16579648679943199,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04988287565286036,0.15203397682527248,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023884203935297298,0.05095723368869983,0.63952982409701,-0.07629098766207945,0.12405939553267406,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03181668485728567,0.0972913730194336,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004627480908696069,0.041509894219914925,0.911292029141284,-0.08623045080439012,0.07697548898699799,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.03205644918171856,0.023433258931987565,0.9891749114349121,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00030835963750853865,0.06803914754795402,0.9963861691532387,-0.13406433790306233,0.13344761862804527,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09338116338764377,0.12781574738138113,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020282076145726566,0.06258798918784989,0.7460629970241641,-0.1433217970004671,0.10275764470901395,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.044603553509393996,0.02364998477714354,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02946317271955563,0.06115410242628197,0.6302197058987116,-0.1496840615720232,0.09075771613291195,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.009794446813052615,0.01601068048439594,0.9602080663001867,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009070102855251687,0.054331325097008755,0.8675005347291116,-0.09773810684038504,0.11587831255088842,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.026656931023543322,0.09286713626874439,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01855093205646606,0.05302311075267502,0.7266227613751548,-0.12278736512477127,0.08568550101183915,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08724520618090711,0.11950918707194287,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006394924354646208,0.04467021057092832,0.9885850716645761,-0.08717624202875222,0.08845522689968145,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.051134907376807565,-0.00884580407694246,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04720444342580499,0.09518765938250762,0.6202287541435572,-0.13992192364900538,0.23433081050061536,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.16429245905011272,0.20050997399179368,0.9580596405456464,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035813345211460644,0.05595605708684405,0.522519229850069,-0.14581556342354143,0.07418887300062016,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09402213893779367,0.0976468764622889,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037046309210464215,0.0542187547975689,0.4948258383114704,-0.1436332205643689,0.06954060214344047,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09400274172931496,0.07885735261330461,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029885689370636962,0.04161427094546061,0.4730749901076333,-0.05192247138262447,0.11169385012389839,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.06239092365798002,-0.005386829191139057,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013291799552836592,0.04581970286614922,0.7718972247620258,-0.10336728405797838,0.0767836849523052,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0634793302204171,0.08093255715991127,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028342606955765022,0.03921890317198593,0.4702974004228906,-0.04875657710696583,0.10544179101849588,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.02396496164944165,0.026906751214725865,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027593303627552888,0.04271941448715351,0.518699098010051,-0.056387423374261406,0.11157403062936717,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.047305773282939084,0.004588633113278378,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020077146585731967,0.04725627811188895,0.671167880057781,-0.07282245512650105,0.11297674829796499,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06561578972407271,0.1230687691370234,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025832279465305943,0.04354223731855833,0.5533336350274034,-0.05976600855424767,0.11143056748485956,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06427439759842324,0.0629491108413764,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02128979057385091,0.04909097561231093,0.664752646468226,-0.07521658411885411,0.11779616526655594,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06617637609013291,0.11071180895561981,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02373693122745774,0.05045805696785758,0.6383030704038097,-0.12293080731707348,0.07545694486215801,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.0354945878173488,-0.013875692053518036,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0499654486686429,0.07400886789378698,0.49998169148432237,-0.09552621138607346,0.19545710872335925,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06206676499710446,0.17813562933968075,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009669482576827704,0.04961914002737546,0.8455897573591649,-0.08787519360212417,0.10721415875577958,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.014523228004561467,0.05297507001277086,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05674933826581416,0.0493446510411938,0.25080091411532945,-0.15375440534922336,0.040255728817595024,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02995469072161203,0.0026183768666353992,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016349186872287917,0.06594275135206301,0.8043148379766867,-0.11328555333960041,0.14598392708417626,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.039026184885712925,0.1334587571237317,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028447878594181065,0.046893826665122706,0.5444284972733051,-0.06373919144205152,0.12063494863041364,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.057257015380193385,0.10676080269659032,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044595683922255186,0.07027016177548309,0.5260286462850656,-0.18273754151290195,0.09354617366839157,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.11288208811732921,-0.04318990194052467,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04244347380671798,0.07772693340419591,0.5853276907070348,-0.11035741200291624,0.1952443596163522,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09421825543526123,0.16402629972209365,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035661221341121284,0.043256188526554,0.4101892232084784,-0.049374732531326036,0.1206971752135686,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04160091267430385,0.0689303041105774,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00324110900824299,0.04638206675841497,0.9443250307524438,-0.08793990863865686,0.09442212665514285,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05195715408791924,0.044145320409037334,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06291514285144029,0.04800279531008144,0.19072049192773316,-0.031452013081190944,0.15728229878407152,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.025369060072137257,0.05479686082869701,0.8119345039490624,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05523356253602516,0.055087696082466324,0.3166324152113489,-0.05306157262440012,0.16352869769645045,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03684920735767582,0.07899099542608906,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06490740670113743,0.05192106357978005,0.2119822215494196,-0.03716254717073954,0.16697736057301438,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.006763403778514132,0.039808785202705255,0.8272946081671145,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03175505975711581,0.04397841485102179,0.4706762669394875,-0.05470069568604106,0.11821081520027268,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04138241671504359,0.06948094395091586,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030463597278825114,0.041530219562295655,0.4636626831407378,-0.051179329555656294,0.11210652411330652,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03654359260901541,0.04667684835298541,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030581073608019458,0.0481054440960528,0.525326798337554,-0.06398787628118206,0.12515002349722099,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.040744563030697935,0.07429873856852913,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04733906892148687,0.032881106009309664,0.15072739986581463,-0.01730084294144249,0.11197898078441623,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.031090723076449178,0.07096644885016308,0.7683177847971997,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04043823178211677,0.04622065999296065,0.3821520590512574,-0.05042548148061505,0.1313019450448486,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.060965636064453134,0.09799486546432346,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04967229452286319,0.03482105131102681,0.15449775658332476,-0.01878129359798754,0.11812588264371392,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01943600336980917,0.05986794045590383,0.7729635971926234,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01468931591992065,0.032534073853917524,0.6518680802494239,-0.04926837655745035,0.07864700839729165,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04416521558001868,0.054064235951715015,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0045423374807742455,0.06401736548655164,0.9434689498207491,-0.12130734840193345,0.13039202336348193,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04698890884304736,-0.008767520464479463,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04024885944500887,0.04889497861509336,0.41089839518570337,-0.055872211036154244,0.13636992992617197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.009197708397584842,0.03531515760759599,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02626453092745291,0.036904402568504954,0.4770679056785674,-0.046284650620966275,0.0988137124758721,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04175826902046597,0.05505064520854077,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049011946524951375,0.05217208991134038,0.34807351112472784,-0.05355149196215539,0.15157538501205814,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04468527854588348,0.09020608933670156,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03298552560809235,0.03949095064943774,0.4040617607524323,-0.04464846786646418,0.11061951908264889,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02789113087602397,0.04644967986755937,0.9235364977981017,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02264481090382201,0.042016632121613294,0.5902198178865914,-0.05995433878260397,0.10524396059024799,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.024035346385505696,0.0513045918424109,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017574905084881482,0.03414413777365004,0.6070260730056176,-0.04954796042029844,0.0846977705900614,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04508898184030398,0.06911114169931329,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025575575115913872,0.04799144501029758,0.5943830693729133,-0.11992041785818469,0.06876926762635696,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06363344759491163,0.07632854123267532,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01570837402228226,0.047029337834512,0.7385440691920355,-0.07674509307624156,0.10816184112080607,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.03702153585803789,-0.010185703389898621,0.963305304214035,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12780608898173776,0.057164751849969365,0.02723287395860953,0.014614170907690113,0.2409980070557854,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.03718210126665085,0.06018196380958256,0.3910019750822703,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18100942399998504,0.06296272791553714,0.004789733359150693,0.0563369342349857,0.3056819137649844,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04155610622462572,0.07430542101200997,0.12673634468312733,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04443493076750346,0.04621466264280663,0.33825554013820724,-0.047074717020587506,0.13594457855559444,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07679705080411336,0.048026712717951156,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1795446740071565,0.06830361878952537,0.009703761248786006,0.0442966868825683,0.31479266113174476,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.050610248796390554,0.03252481946659862,0.199353905835858,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1049867472942399,0.044936464353230426,0.021146329266789516,0.01600805978138671,0.1939654348070931,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.006151055260059751,0.027090732737966736,0.33504311408065957,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044968237917315745,0.04665229099364994,0.3370497354911862,-0.047407957714200574,0.13734443354883208,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06669524647160804,0.06561247495142752,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12207905398304254,0.05998533526142613,0.0440574651591777,0.0033020990445201126,0.24085600892156497,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.004528506989276245,0.02371739700828566,0.5032059833576297,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03686588634691535,0.039916348893728686,0.35757467542572374,-0.04217247116493416,0.11590424385876485,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08351055158916704,0.06709736731154262,0.9120511198404183,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04236822735010141,0.03640526436846586,0.2468356254038895,-0.029717832127153933,0.11445428682735675,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0274333340025409,0.017011182123015653,0.8552269457897888,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15294112137553084,0.057835707379790637,0.009287039193290972,0.03842064433979675,0.26746159841126493,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04598867961223272,0.0061432243877038595,0.1981734331084509,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11341777677030712,0.04317177147743024,0.00974418184231707,0.027933357402755737,0.1989021961378585,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.003512653149793483,0.07184148577890599,0.199353905835858,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19305551928949072,0.0652844509877031,0.003745715988615551,0.06378578595620019,0.3223252526227812,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.11265788738235559,-0.0018906604599104823,0.10360102270951306,0.9900834052574969 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07321413704796423,0.04684518288091221,0.12073262859133264,-0.01954400378568369,0.16597227788161215,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.019775658830608576,0.03838716640841999,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.066673984800942,0.038245371182760404,0.08386021638707904,-0.00905566995190861,0.1424036395537926,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0032730753766426995,0.014088233188341428,0.6500804664849935,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001077984662233803,0.10697602508485661,0.9919768224682296,-0.2129011987133037,0.2107452293888361,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.025299447928550607,0.0049066141499434545,0.9994099232379783,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05944372885109228,0.11481231226621853,0.6055959884727591,-0.16789611647943106,0.2867835741816156,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.25580916036693346,0.14310705519596617,0.9533164021566217,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026972069260695862,0.03163710331163603,0.39562402655505435,-0.03567255509715143,0.08961669361854316,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0042672098515180975,-0.032255976027813694,0.920957044807631,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10201528390610118,0.046126274401818435,0.028900693523580597,0.010680653663068446,0.1933499141491339,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.024206721863688368,0.08037625928694737,0.4046097093301284,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053688857446913006,0.03907863827611461,0.17206533524167333,-0.023690749374518115,0.13106846426834412,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.013317215845125947,0.0035489532611841183,0.7850787711519817,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06723245733634842,0.04010561203356879,0.09628803661545769,-0.012180660095310492,0.14664557476800733,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.036331023967455335,0.06002602770820493,0.6734224093863465,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09642859716971808,0.06038169523155789,0.1129214466218276,-0.023133190096682466,0.21599038443611862,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.057833158482683014,-0.021507299063984235,0.7080335255008432,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10264888451014585,0.06548304151952711,0.11963817340365795,-0.0270140779106688,0.23231184693096052,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07281439128288214,0.0962287152383524,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0397773253713045,0.05227732641218907,0.4482275247666542,-0.06373700219735305,0.14329165293996204,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07060564559324721,-0.011493269322456846,0.9334305759126671,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20704040461748363,0.0781991166166041,0.009204561646412026,0.05219834346832303,0.36188246576664423,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.020042323574945887,0.06431305826287374,0.1972100984392524,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07566661059092383,0.04102093293816835,0.06758473184292431,-0.0055589336508228004,0.15689215483267047,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08250695386120604,0.05656989770745382,0.5994274875632772,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06727533354929066,0.039863914613441,0.0941026454585612,-0.01165919885064072,0.14620986594922203,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0016574685309536411,0.06883604212802215,0.6707240267079618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0499401847515244,0.039293862896568686,0.20622845458096564,-0.02786558831427169,0.12774595781732048,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09263445897699545,0.018390569336582112,0.8201610583485497,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0832002341405125,0.039282006112765465,0.03625372590341464,0.005417938690859991,0.160982529590165,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01773064104080994,0.09027683299929884,0.45679694638302454,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04975253028542267,0.039638382351366144,0.21187977520924783,-0.028735425710244213,0.12824048628108956,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03095589495955579,-0.0019299442665656657,0.8272946081671145,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11700586457635939,0.03748638207247467,0.0022602929183665357,0.04277908406699425,0.19123264508572452,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.03382158898051297,0.053751070844252416,0.06954343095346341,0.6646053787012689 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05171663155001408,0.03498605190026406,0.14199433795596436,-0.017559245494332625,0.12099250859436078,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.023315842538316613,-0.019194992768783177,0.7607934302264618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09719555601214097,0.058210631509351914,0.09760297634702277,-0.01806730824620653,0.21245842027048847,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05328731829505253,0.025260348036140925,0.6772213442508546,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17976752979329363,0.06517172389207972,0.006726889784272782,0.0507210073681168,0.30881405221847047,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.012337534414817317,0.05135424949914853,0.15751637494854673,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019026560837108717,0.04210212858212841,0.6521532346825982,-0.06433985876563557,0.102392980439853,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03950094997527251,0.005752587712146978,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13669290385632346,0.05971562203496656,0.023838945052736104,0.01845000804418409,0.2549357996684628,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01144534055695184,-0.0065341811492745094,0.3634085581572868,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07043939483178377,0.03642306631118075,0.055497104045933304,-0.001681914270041468,0.142560703933609,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.16398363013028597,0.16153104274795027,0.5506521745982841,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05479895518766813,0.04940460753159461,0.26958600556173423,-0.04302710208051769,0.15262501245585394,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.016366769927019898,0.012863244175419607,0.870012817074135,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048768323381157413,0.039726762547491745,0.22202233814696537,-0.02989463422993628,0.1274312809922511,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10717583669128702,0.18642667052060305,0.8355377918591873,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052847000688417564,0.03559868712161326,0.14031482308112922,-0.017641955282016897,0.12333595665885203,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02325230756039683,-0.006126819495407772,0.7568502146876953,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0500680169822081,0.0335605830051016,0.13837960092422033,-0.016385289278978296,0.1165213232433945,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.008279338193585698,0.010936593177466756,0.7523679946140144,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06358423681325076,0.037235178370144444,0.09031100022666935,-0.010145135276172543,0.13731360890267408,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0015681501292608873,0.014786341531073185,0.6631718036996311,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06999021493682153,0.039733622280086464,0.08072446878010121,-0.00868632562993528,0.14866675550357833,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.011958335833776665,-0.0017096298184885621,0.6398297823258919,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039522607429320886,0.03885573699665331,0.3111395845332611,-0.037415632596193724,0.1164608474548355,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.027687541044374035,0.020299159657400014,0.8977920836150588,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054766334115268316,0.032290109963899805,0.09248696057346643,-0.009171308634031837,0.11870397686456846,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02487903326792346,-0.007764829570274736,0.6674195391201606,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004077546738262283,0.028647238665161976,0.8870549527318783,-0.06080194047909582,0.052646847002571245,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.017510929074419694,-0.02769307801405671,0.9882859306472693,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02193424624145576,0.030027089592476075,0.4665313686774355,-0.037522390150038734,0.08139088263295025,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03262047024910955,-0.0030436714573479646,0.937664825139976,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058374792697931596,0.034583274405027266,0.09404028407578333,-0.010103544677869544,0.12685313007373272,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.012852047282802174,0.006689089951553366,0.6707240267079618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04079606379816671,0.030961358300188372,0.19015382348228207,-0.020510517946017583,0.10210264554235099,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.004570421276150384,0.015194401841069004,0.8114284597256536,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04480411184099882,0.030332351525394263,0.1422887182186783,-0.015256973666144535,0.10486519734814218,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.030090342281181296,0.007932273153760435,0.7607934302264618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04243020802315263,0.03532878630354614,0.23213257009381436,-0.027524317370779858,0.11238473341708512,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.01838209525183691,0.02441322932792036,0.842940686827401,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09076105439086533,0.0645676232475211,0.16242637489574768,-0.2186113972044028,0.03708928842267213,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.5902533157939752,0.0953478536468251,0.7815068115919459,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1383721492889609,0.05616144961001396,0.01517560689961467,0.0271668698562669,0.24957742872165492,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.21701591152410357,0.06635004186299584,0.26949433460657995,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09851038253796306,0.0756727180527614,0.19550076204341044,-0.05132915712712981,0.2483499222030559,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.028465274896331567,0.008161695048651744,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07967661467603956,0.04896532751119537,0.10633864990929229,-0.017279624278037295,0.17663285363011644,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.026166631652829207,0.10581709524971085,0.6896374207352632,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07091177572360466,0.04530287126295693,0.1201722052261955,-0.018792434065919614,0.16061598551312894,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.042618604799735296,0.0339848362480031,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07621695672614662,0.046586298516783614,0.10447385193324446,-0.01602856721008164,0.16846248066237487,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.002427376589129182,-0.021197833141293403,0.6865177455679591,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07385619369960211,0.05170047348301977,0.15575598781679173,-0.028515907455291326,0.17622829485449554,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.09561365063511924,-0.03474562353864031,0.7751667907772368,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08922268667320594,0.06278071854821281,0.15787975473253646,-0.0350894063660461,0.213534779712458,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08251905739421085,0.09170257389980913,0.780274991675152,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13702698165175808,0.049507759238502716,0.006547080822719828,0.03899667370147039,0.23505728960204578,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0661871211267278,0.005894226138977298,0.1556009807507485,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05559151449878837,0.03786269348673388,0.14467743030305313,-0.019380400195449128,0.13056342919302588,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.019041528445580533,0.0074731844558725705,0.7635967032883216,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0360334200894339,0.036292348905710245,0.32279010088976,-0.035829055493972445,0.10789589567284025,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0014153237994978787,0.007163861413727795,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09064239379050365,0.040010591012726616,0.025292848948505947,0.01141742747047221,0.1698673601105351,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.010152841764908795,-0.010373060073851937,0.37388200177512143,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06322742448633839,0.04856681791954968,0.1954770900667912,-0.03293972567456627,0.15939457464724305,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0018961586871479672,-0.017254501760092824,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0783712845531852,0.053634893338141434,0.14659617259444307,-0.02783116111779066,0.18457373022416107,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.14556446697047837,0.11174088718468143,0.7662201971017615,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09015549533838593,0.050256257092820465,0.07536596615728579,-0.009356913120741467,0.18966790379751333,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06323070031919492,0.04817992262215268,0.6286648421036044,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06127667425014381,0.0425622170683641,0.1525787712443865,-0.023000766507340786,0.1455541150076284,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0965452324464116,0.05752085989709558,0.7692078902000675,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08024517604228056,0.05187254082390181,0.124526247016936,-0.022467635633030378,0.18295798771759147,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.039757688644204904,0.019700258514448656,0.7259506085296737,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06136143041628728,0.04375773374277944,0.1634292400154485,-0.02528325276047237,0.14800611359304694,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.012564052688169647,0.07461601801879332,0.7815068115919459,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051643097788301395,0.04044557511933685,0.20413970672170104,-0.02844318050747624,0.13172937608407903,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08925277185159222,0.04096400683756144,0.8179445630780711,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056746042605589075,0.03767570362210773,0.13467326864657536,-0.017855613480809274,0.13134769869198742,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10149822518082362,0.07328193174915111,0.7465338034333207,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061765990882132416,0.030265849729160087,0.0434848675332871,0.001836585573494455,0.12169539619077038,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.05618324543539628,0.017463595774304255,0.4988191885538049,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05095576047718552,0.03308435268844794,0.12617215935567977,-0.014554562192844643,0.11646608314721568,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.008671451529304756,0.015523044090781164,0.7263564310373228,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013176339738026836,0.03151948203096191,0.676672754144043,-0.049235382736492556,0.07558806221254623,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05775780388102877,0.01559557445169986,0.9619695749374265,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14962800747544283,0.0749024225797406,0.048036765171921486,0.0013137297812899906,0.29794228516959564,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.014087823803098639,0.01787023284225461,0.5195038718456577,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02449138306137992,0.041688572555023666,0.5579915667050603,-0.058056154303199034,0.10703892042595888,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.13382015312438333,0.07481980457285811,0.949991921327294,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15990877340973647,0.05034028250746128,0.0018985579085601513,0.06022998623746216,0.25958756058201077,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.13616122656106533,-0.01972092884925846,0.0615132762373489,0.5878636369873123 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04920792112389874,0.03469804771781686,0.15875298133478769,-0.019497678874374078,0.11791352112217156,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0031433237789417375,0.00937506051644753,0.7804909419375794,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06244451276544063,0.028742897105722462,0.03179898629459597,0.005530705758274176,0.11935831977260708,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.08722353672153757,-0.01826205119317403,0.42710719662690827,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06579772603727013,0.0333256654437929,0.050654117607343875,-0.0001904199897986153,0.1317858720643389,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.01893044080384671,0.00509427596871467,0.5297659888894541,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03754210861293996,0.03124863166637693,0.2319816718592684,-0.024333303088134778,0.0994175203140147,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.013104155856923583,-0.013450599156777564,0.842940686827401,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08363869760968048,0.0385549734769989,0.03204551364002406,0.007295999392267022,0.15998139582709395,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04933893413184212,-0.0016272753921983461,0.4282445913712306,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03634467894195064,0.02759523914082403,0.19034792843740767,-0.018296650670741106,0.0909860085546424,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.02925224357881533,-0.018726702201467722,0.8114284597256536,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0455422694098086,0.03280972995173234,0.16770837288146442,-0.019424272813187232,0.11050881163280443,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.030285400083312212,0.011688795283206236,0.7842677313995,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015682457170396305,0.0285853243370791,0.5842946548930825,-0.040919340017051324,0.07228425435784394,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.027487518180551077,-0.017508105715379096,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041573759076138805,0.03661170232916751,0.2584343444869729,-0.0309210681815915,0.11406858633386911,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03307174581764456,0.021115261847066538,0.8664830381179188,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05171411811332291,0.03368549077105399,0.12738812944841582,-0.014986517999790464,0.11841475422643628,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.001388888407926135,0.03259075705633341,0.7274870299003775,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06701712504520206,0.053671811864869176,0.21424526336247454,-0.03925842299598524,0.17329267308638935,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.045276455121813296,-0.03283588357885571,0.8289622204693651,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13112620825264165,0.046961282909508406,0.0061009939126904205,0.03813817776671735,0.22411423873856595,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04361900783477652,0.09826252515835024,0.15040276297806385,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08748409290855774,0.0417936945313472,0.038452055220090514,0.00472840353165091,0.17023978228546457,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.017839604756416005,0.028403666030887995,0.4724959974258181,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024808040146153953,0.03942504005168652,0.5303943024644922,-0.053257476788280855,0.10287355708058876,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.011530203401973985,0.012745611808029252,0.945915518526879,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09635214978541623,0.048422162738484355,0.048901977158013386,0.0004714313306634077,0.19223286824016905,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.007721435726815179,0.010122902598364516,0.5231588877093131,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042645181701973345,0.03353758836040847,0.20600776177027613,-0.02376259286609772,0.10905295627004441,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.007069439109634591,-0.006224215061693092,0.8201051218317211,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09310196076683888,0.045464978222810815,0.04278308643146202,0.0030767630061401263,0.18312715852753764,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.020863969945785682,0.029778205026131817,0.49583625418844224,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05352182187799069,0.03748181357729385,0.1559279715446535,-0.02069591255463145,0.12773955631061285,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.02672242195866878,0.05658682990459567,0.7755364900510398,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1245714526695052,0.0475538954534886,0.009950059488502033,0.030409990158477215,0.21873291518053317,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.03011716915362773,0.03079227951661269,0.20252198005058755,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03668774959885253,0.038478691334572296,0.34229166229292474,-0.0395039023577685,0.11287940155547356,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03682148414641259,0.0899181655719874,0.9045618832985359,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05413766471820621,0.040953367535023044,0.1887255153460271,-0.02695409327712172,0.13522942271353414,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.023391218010005297,0.04861207790166793,0.8085168201280608,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0977979075065615,0.04477870990517315,0.030921606926611667,0.009131589556812175,0.18646422545631083,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02496340637187346,0.037309072845245025,0.42002168600416523,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09042466076723722,0.03759290854995397,0.017696641528456986,0.015986947192979217,0.16486237434149523,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.02419527196818616,0.04637201970270212,0.30274987166571454,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03612757541651832,0.0367303211342447,0.32731273101904024,-0.03660212892248713,0.10885727975552378,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05529715624271096,0.036388904706234286,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04080227722870851,0.0328881060067649,0.2171794311534353,-0.024319457411172057,0.10592401186858907,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02688695566892628,0.007873712025226347,0.8308625663641223,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08340319138300856,0.03730589155868323,0.027239114666225177,0.009533800117697902,0.15727258264831923,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.07035393088516964,-0.002234304514581057,0.3910019750822703,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027767828158087798,0.036012463461470204,0.44219870331864897,-0.043540446291765414,0.09907610260794102,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08289554872695289,0.02159814482301235,0.9330352189956562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035590091155367126,0.06267103094874775,0.5711813297436172,-0.0885048094817387,0.15968499179247295,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06301722687208203,0.023484064819094465,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035025581615125104,0.0385948201262546,0.36596583931569726,-0.041396016947555556,0.11144718017780576,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08694201138746924,0.0330729033412825,0.914684777397777,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059854876424277136,0.05997756501750882,0.3203263993495182,-0.05890669265522482,0.1786164455037791,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08412204319574004,0.061102678232493636,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042674686911152435,0.040618421753603536,0.2955602329895858,-0.03775384498377732,0.12310321880608219,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10162549687033018,0.04180461906027006,0.8831753988928314,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05005944372335527,0.0656264085803891,0.44709558426343865,-0.07988739979695575,0.1800062872436663,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.14463899473440028,0.09248928173819895,0.9330352189956562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024335624577689882,0.027379454237009528,0.3758887054668796,-0.02987842937362417,0.07854967852900394,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.023416887209407242,-0.01175387820461394,0.9164018869766861,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013085141789468886,0.02823685788038516,0.6439195070700432,-0.04282665701014046,0.06899694058907824,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06901088706571389,-0.006551836105297318,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009891003982159197,0.03057270950786883,0.7468663289677329,-0.05064601433638005,0.07042802230069845,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.034290673889521,0.018601476177610578,0.963305304214035,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02593015774690954,0.03445298774484289,0.4531619199765866,-0.04229019902916056,0.09415051452297965,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.010875758550196075,-0.004767648447982224,0.933731420853472,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07914195392426518,0.05893131638159603,0.1818432162918887,-0.03754793836055499,0.19583184620908534,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.010753817183529897,0.04704370759082927,0.8014130815101496,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0919587180433925,0.04928432172781414,0.06452015424152484,-0.005629161319591805,0.1895465974063768,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05628502668878988,0.075699314327893,0.5880149074273526,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03044247871646253,0.03277987118918992,0.3549274914090753,-0.03446494017451283,0.0953498976074379,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06471096923894641,0.04974185999249874,0.9103116080146171,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08051162579391895,0.0360859109883288,0.02754733168803249,0.00905791790520924,0.15196533368262866,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.003673511095391142,0.02956500828401709,0.39228691037577734,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06091005780206382,0.035879544662369554,0.09219202518678232,-0.010135024150115496,0.13195513975424314,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09238321387961426,0.06206567291499134,0.6674195391201606,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09863131518980144,0.0403665769936564,0.016017959782733016,0.018701461072921532,0.17856116930668134,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02525253790948356,0.027944203774817915,0.27874836487218185,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07155258254116305,0.03850568999048951,0.06560703802380977,-0.004692529450703337,0.14779769453302943,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07486348889237658,0.03698738331661296,0.59315338021982,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08573552280417895,0.03965847793998749,0.03263206755605634,0.007207775535966243,0.16426327007239166,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02024931078930489,0.014983059836473528,0.43389171232826673,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07522145794743143,0.04986880132077827,0.1341058791358599,-0.02352374938535466,0.17396666528021754,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.016638691878156607,0.02884351885126609,0.7444803357286909,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12441216139470204,0.05486234380420573,0.025150670674546443,0.01577924120755321,0.2330450815818509,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02525394905579271,0.03138652779052761,0.37386895845421286,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09493910775760706,0.04765711657927066,0.04864638102649911,0.0005732571081734639,0.18930495840704065,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10745964910097085,0.13860747203500004,0.5225371753563598,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2152218041656969,0.07016158397044263,0.0026727225059030722,0.07629486041597058,0.35414874791542317,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.056903727601298415,0.005676777432977534,0.07911164839882295,0.7560459172479591 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1113135605222464,0.053284130508109186,0.03883386755510087,0.0058056602876722235,0.21682146075682057,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04015902187191342,0.08144628896988923,0.47377644413826986,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11401603217361375,0.04685668168214718,0.016449316147411703,0.02123512256506141,0.2067969417821661,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02354550999176434,0.04331173302440623,0.285097536196843,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05227904090556882,0.03828452103523203,0.1746590643012879,-0.023528134465322946,0.12808621627646058,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07425862157748925,0.036876417085027785,0.7896200758961603,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003082085614328267,0.04016547208437124,0.9389634604852954,-0.07644956069652742,0.08261373192518395,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08074230614613548,-0.007503818419763529,0.992787535469879,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012092401678709692,0.029745127878660963,0.6850805818708395,-0.04680592235810263,0.07099072571552201,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.025797197999261504,-0.04197971894236179,0.9621831471002781,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031974398999114695,0.04397164730858315,0.46855641261511405,-0.055093854402858716,0.1190426524010881,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.19010223337280518,0.05556744543376553,0.937664825139976,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18791294465506986,0.06156257692908524,0.0028007130351922226,0.06601289368532168,0.309812995624818,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.05415872191392642,0.0423049950583054,0.08173551497557302,0.7811214105906662 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022585759233411253,0.03521232198667666,0.5224857019019609,-0.09230967364790243,0.04713815518107994,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08950566770045641,-0.0065676535993588695,0.9438759903131516,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02160067984204546,0.03340268582313916,0.519087683493437,-0.044539974228649096,0.08774133391274001,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02091823914462234,-0.007905261273311051,0.9438759903131516,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05269419672691466,0.04063677494711164,0.1972390421846846,-0.02777067632421252,0.13315906977804184,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05901200955220777,0.06964631100775646,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0364976353947936,0.038332737000739935,0.3429624694892287,-0.03940501240344213,0.11240028319302933,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.021738014251935892,-0.02130478347342099,0.9046447408422388,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040321333374689655,0.03913113863403028,0.30490472596282564,-0.03716222939896262,0.11780489614834193,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06720489053308012,0.08433220728339734,0.8931120718424022,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02865573032189789,0.030599434825131853,0.3509232199103348,-0.03193420679405132,0.0892456674378471,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.023644450359324807,-0.008033648839730883,0.9088510667694087,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04296244489787582,0.03322963147079211,0.19855166477245353,-0.02283554427112136,0.108760434066873,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.003709167168571216,0.017685088188367837,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11566380938887993,0.05797542198536999,0.04832248785835364,0.000866683479903263,0.2304609352978566,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.05701990180106817,0.017395409524801324,0.5211737888853413,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10745810225298813,0.04332305017562716,0.014522159051372883,0.021674135953831136,0.19324206855214512,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.007160531572102854,0.029350970671562594,0.262949343295113,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039082916022069744,0.030824904989797196,0.20730859011647537,-0.02195347453907106,0.10011930658321055,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06288854320662385,0.03531252914190847,0.8210381131305959,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10587417942929245,0.05866051280733358,0.07362490766799318,-0.010279494731594924,0.22202785359017982,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08647074846708268,0.05114755175826228,0.6234452489529284,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0586960781894291,0.04379370420349533,0.1827058159962694,-0.028019830092149055,0.14541198647100725,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.030571415632477374,0.020434594655737333,0.8014130815101496,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06982165693435503,0.04977547298225261,0.1633003030671443,-0.028738750966849358,0.16838206483555943,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0050318611363599905,0.018377732996453153,0.7815068115919459,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04056899149029801,0.04860352056147912,0.405563452839111,-0.05567083356735564,0.13680881654795166,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03067501970051841,0.06262866977152141,0.9237532919369174,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09783182187829366,0.059155290779730675,0.1008009889246132,-0.019301562084595505,0.21496520584118284,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.20506631119654514,0.05476809813081416,0.6821468457660524,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07766140852255872,0.05614010558233471,0.1691473621467698,-0.03350160760356517,0.1888244246486826,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.15951615472675923,0.07610281596003937,0.7842677313995,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09300176195994009,0.0545753751211717,0.09097268754731522,-0.015062931573394917,0.2010664554932751,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08707481481989252,0.07971463192087684,0.6643433245175604,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12380592698023982,0.04809257534059286,0.01126976842250035,0.02857782449132351,0.21903402946915612,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.009486987477769401,0.017580071181563784,0.22034340329509305,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01656713895831645,0.04579555392811907,0.7181706770999587,-0.10724690963224552,0.07411263171561262,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.16451397987778404,0.02506779284952101,0.963305304214035,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09945609853604673,0.08628988207059135,0.25139237165613854,-0.07140648628874585,0.2703186833608393,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.4241384161116567,0.1563094436889928,0.8586715345122323,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04695760548879819,0.0397637880420646,0.23999185656243552,-0.031778666299523826,0.1256938772771202,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.012599864795493946,0.020110701396133242,0.8466912699522725,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03733004603714645,0.03827773640844673,0.3314186870786814,-0.038463695095086146,0.11312378716937904,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01141189422823634,0.021644573731167138,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02320969154231033,0.050892574953256775,0.6491833347413389,-0.07756268983363467,0.12398207291825532,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1491339525516177,0.05790189803057687,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03343566971877762,0.03625475608178641,0.358268242821409,-0.03835236831862264,0.10522370775617788,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.051844977743615586,0.033506132305764866,0.9129801963134333,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04022174505945373,0.04622859449975201,0.38601816501843544,-0.05131548919685317,0.13175897931576064,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0711992382681412,0.002659536478144756,0.9192918506885728,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03319063691226068,0.05110588238921403,0.5173001382899012,-0.06800411449126402,0.1343853883157854,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.11383869362877753,0.039920308170732395,0.9438759903131516,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04152507411794636,0.03201919175240472,0.19718116946249964,-0.021876123514250813,0.10492627175014355,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0114430716066209,0.003315721854560427,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019139904093586475,0.03109103320161837,0.5393285568694619,-0.04242344690689491,0.08070325509406785,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.002954627958233606,-0.017257510105628555,0.9471659478826966,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06728029750572297,0.037712023386621295,0.07696339508216293,-0.007393275341900513,0.14195387035334645,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.056062192895650266,-0.012885365707790138,0.6304803200848395,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07618131155033239,0.05692469490304726,0.18335590617539102,-0.03653526979277959,0.18889789289344439,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09723747589058,0.06841428648719457,0.8024330451816867,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12720137870094386,0.06445641636932467,0.05076219736810483,-0.0004287633868191032,0.25483152078870686,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.010126200758124064,0.039167595188387305,0.5301977930368633,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07822947093589495,0.05012664652889835,0.12126511224842138,-0.021026295661626754,0.17748523753341666,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08817984507776244,0.05020362804644415,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09490907737376145,0.04816069722412057,0.05108282936528964,-0.0004539132483099839,0.19027206799583288,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.17360103225295295,0.10234253506046222,0.5314488853232886,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13601342531346272,0.057253847704212185,0.01911671230132089,0.022645088549438808,0.24938176207748664,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05608560989363746,0.06673232654003187,0.3154853684987219,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07632507451745216,0.034606221485250915,0.029338328174342537,0.007801299630935829,0.14484884940396847,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.012273735639583954,0.026303188322513996,0.4079068880915672,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1488395731170327,0.07033612301803503,0.036418787038566706,0.009567024620737163,0.2881121216133282,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04865070662967525,0.022690774080269722,0.4574245751774407,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08779948329393558,0.0537161983697737,0.10479524865208986,-0.018563954460128138,0.19416292104799932,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04511688049943638,-0.00296436759348011,0.6874914742151151,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013620878858393415,0.024332227178289065,0.5766765162858098,-0.03455936117050627,0.0618011188872931,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04550232430813697,-0.04267758538115123,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045992307851821276,0.035684787061996064,0.19995044533979067,-0.024667134599925464,0.11665175030356802,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.15020744766088312,-0.054361684109017205,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008893923021573302,0.036578419432493715,0.8083103603499391,-0.08132284681971272,0.06353500077656613,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1408734563123927,0.04063181030572364,0.974516576191754,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029578376955070748,0.03778946573470373,0.43534939737217915,-0.04524853947642089,0.10440529338656239,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.18601407209575116,-0.08858148476990255,0.9302388919528202,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04312957133395942,0.038914268087286215,0.26995744786049075,-0.12018370876480333,0.03392456609688449,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1521352326696314,0.013972546221921789,0.870012817074135,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03128111996814359,0.030260757952226817,0.30336376583210684,-0.028638203113618012,0.09120044304990518,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.10750208431113764,-0.04941973592367626,0.891229301693288,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001616169316079396,0.0321330082079691,0.9599706490529056,-0.062010396265716056,0.06524273489787485,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09761121876997562,0.04104501921567229,0.9962057403241632,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02254327227755402,0.02995457457002036,0.45318731123670286,-0.03676977712693687,0.08185632168204492,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.06842933527540832,-0.07301656503737868,0.933731420853472,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00771950287455862,0.03388102899821648,0.8201605147780776,-0.059368318457995756,0.074807324207113,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06610932700254196,0.042661895432911885,0.9788034269246562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030495251185816502,0.03255654244201039,0.35081727881859737,-0.03396995448046629,0.09496045685209929,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.07613870699296622,-0.05750871934530359,0.9088510667694087,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023190332331236616,0.031054640063528118,0.45668189998193665,-0.038300956621009505,0.08468162128348274,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04749686977543357,0.05666131179958321,0.9353936944091839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01886792736979641,0.03411403862477452,0.581243478782986,-0.048681276295511625,0.08641713103510444,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.08859458699398381,-0.008709354165835516,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01773855972951745,0.03885043568296761,0.6488010324103114,-0.0946663026244581,0.05918918316542321,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1887060390817038,-0.01074824147925642,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006628714283144233,0.03588656170913956,0.8537685803055315,-0.07768769068876571,0.06443026212247724,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.037734608861452835,-0.04740572818936792,0.9832743004559027,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0026974217613643867,0.03562182991565029,0.9397659657483208,-0.07323220277541173,0.06783735925268297,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.026056492470300494,0.027368905425737063,0.992787535469879,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018811436977410567,0.033489802138387474,0.5753724420291958,-0.04750171609834186,0.085124590053163,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.1265897212866059,-0.09798494843700942,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023271161606976537,0.03993664587760568,0.9536311432084359,-0.07675143140641852,0.08140566372781383,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0696653771346848,0.0652883147470895,0.994341785733425,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02199027349036812,0.028695549072835964,0.44499720121173547,-0.034829779682730766,0.078810326663467,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03071599635834354,-0.008506657392097708,0.9330352189956562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021998058154894123,0.030428195002394087,0.47112923964221287,-0.038252807009212825,0.08224892331900106,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01372715841405888,-0.02369754582242064,0.937664825139976,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061919336115564425,0.04897288104160951,0.2085717509532891,-0.03505185958315206,0.15889053181428092,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.08017699185359309,0.07760016716999088,0.82185729615414,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018703148546763967,0.043655543450756125,0.6691158188978521,-0.06773918764538837,0.10514548473891631,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.11421265842977853,-0.01810887324626752,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06645330375137487,0.03327042078504642,0.046317995479147875,0.0010887456761030506,0.13181786182664668,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.054523630027258,0.19829022503689855,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15417755438551645,0.03521766496450837,1.4559359556384523e-05,0.08498735322392746,0.22336775554710542,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02931255788403631,0.27579945694138835,0.0008435926726903674,0.008061958117628295 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029945835763803264,0.025696483384636478,0.24441733356791176,-0.08043029736340683,0.020538625835800305,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.003858743591623833,0.058116790852703305,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2218950002632987,0.03534358011923914,7.353161949937843e-10,0.1524574205519423,0.2913325799746551,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.09054240192152911,0.3686309668092265,1.882883856729245e-07,1.7994147275958123e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17446396113269638,0.02621795687498593,7.38387060233233e-11,0.12295498936939865,0.22597293289599413,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.039324773831599436,0.310491463017008,3.663322802582127e-08,3.500925975516364e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13758930418595383,0.03839079696140834,0.0003711148119261271,-0.21301358251873065,-0.062165025853177,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028737082294004877,0.008428424895246828,0.0156697307290936,0.14975084177720618 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1627100607524552,0.032528267950333124,7.824773545347995e-07,0.09880356935986111,0.22661655214504928,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06034625171327713,0.3136455030057765,6.607771532231105e-05,0.000631484590469606 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0449413635132675,0.026861516851319815,0.09492794796647683,-0.09771470201601157,0.007831974989476569,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014318090296249336,0.10962359125232447,0.6729775750805861,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06753028661204327,0.02179974382779334,0.00205780641562694,0.024701533989284458,0.11035903923480209,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037990772540171275,0.1605347029192082,0.06482090209224861,0.6194736093996419 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2411062568979282,0.034813582216376815,1.3173512493100304e-11,0.17270993479269703,0.30950257900315936,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.07342237086155902,0.37170998238339165,1.0457134217023022e-08,9.993564526727543e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020489787347451965,0.025210948869631742,0.41675147687611536,-0.029040771408282547,0.07002034610318647,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04336751174603947,0.14391322318017108,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2411763725931304,0.03630904532238325,7.961145478546786e-11,0.16984199672315942,0.3125107484631014,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.08400035941978139,0.3711664879981007,3.7173866358061397e-08,3.5525931335228933e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12958709874295213,0.03051121299084751,2.574868327406396e-05,0.0696434038202954,0.18953079366560888,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.026766390642621235,0.22294716406937876,0.0014193961654827758,0.013564736642330252 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16976821771960604,0.028218118793376507,3.4175045799371235e-09,0.11432963831114892,0.22520679712806316,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.003798106902999731,0.25560183051510876,6.028478079009085e-07,5.7612328033875875e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15171485600002838,0.06798750466633482,0.026082794957199555,-0.285286151231522,-0.018143560768534767,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03613347066731437,-0.03958077693509958,0.37989949792706434,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.20868020874161863,0.05391045582941942,0.00012259150417878248,-0.3145951036476148,-0.10276531383562247,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.04143380650205046,-0.06536738868897168,0.005724302118653973,0.0547054110677154 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16462621348180892,0.023168874252973128,4.0774744913453286e-12,0.11910760593453684,0.210144821029081,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.010566603169702964,0.20310220085448832,4.623856073185603e-09,4.41887835335026e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06648381592990912,0.025580902455746145,0.00962237325115687,0.016226429797359505,0.11674120206245875,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.034265089217175325,0.1911819756378189,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1512247150086842,0.02373885507179807,4.2300373311241694e-10,0.1045862976286907,0.1978631323886777,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023883418750316618,0.21729912292268858,1.2914629359409098e-07,1.2342117750762412e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06680828320468388,0.022464292894915333,0.003079408174325907,0.022673927735107846,0.11094263867425991,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.009113974307689671,0.14756389097216516,0.08921292732773375,0.8525807619611617 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1590785167432477,0.03366490872183747,2.9779454726347967e-06,0.0929389300075039,0.22521810347899146,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015227205420875757,0.23802993459741634,0.0002148993741979547,0.002053727836164293 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.096495216795631,0.03136441180185704,0.0022067993889586437,0.034875289294122994,0.15811514429713902,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037875079410328215,0.23534507358301954,0.06869636686099495,0.6565102452826147 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07306632587531868,0.023739403412148318,0.002197611079447646,0.026426831201325794,0.11970582054931156,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.043013067201468504,0.0986121570917802,0.06867967223880084,0.6563506998654062 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20605542077771435,0.03337632632630608,1.3661740678505761e-09,0.14048279593506124,0.27162804562036746,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0798445787094417,0.3746986821531308,2.78068967964048e-07,2.657420395069153e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12347084263659143,0.021436142289347405,1.4590814364129123e-08,0.08135643787343917,0.16558524739974367,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01033623257663724,0.21493633717184318,1.930364740374283e-06,1.84479076128201e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03838802711822394,0.02386273201163043,0.10830274674585429,-0.008493764443303763,0.08526981867975164,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.029685636202366302,0.17050186806751005,0.6975344114730515,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05517576729900577,0.02048814291836496,0.00731394178815544,0.01492384453871877,0.09542769005929277,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.02137840237683704,0.11451891192646615,0.16779788992594766,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020456761425415936,0.024029193125855546,0.39498745116850287,-0.06766558994383516,0.02675206709300329,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03083956027289533,0.11882412464111335,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09774604109597683,0.02300535342704626,2.5567039191308962e-05,0.05254869388357905,0.1429433883083746,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.001565029261068616,0.17039263123614234,0.0014192388608434304,0.013563233329825099 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08535890102170993,0.01902349903817087,8.941012810073104e-06,0.047984483195462335,0.12273331884795752,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.058814397818903554,0.19939813450646773,0.0005501841836151961,0.00525794259348108 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18437363100452456,0.030448354793817845,2.7278497503462063e-09,0.12455343010969505,0.24419383189935406,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023031636346318943,0.2735698389689941,5.035737515871671e-07,4.8125008974832605e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1650335021479327,0.03314951389242228,8.793516723926629e-07,0.09990648316649113,0.23016052112937424,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05073553884989345,0.28734287630139405,7.347677447845218e-05,0.0007021951442211301 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15373279874507007,0.03149452939927368,1.413705900816211e-06,0.09185723638676527,0.21560836110337486,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.07037862795217896,0.3008476130068117,0.00011335350950180892,0.0010832849498032383 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11493200362754206,0.025540289079805795,8.430885903689095e-06,0.06475440835148438,0.16510959890359975,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.009295634991888567,0.15599082918143864,0.0005246569175458251,0.005013986290194933 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1549044877124156,0.03513564236302398,1.269516488929524e-05,0.08587543182556931,0.2239335435992619,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05144933988759851,0.25544852661617323,0.0007577008939189895,0.007241116560416711 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05269785460693567,0.024634249627644194,0.03289461475229387,0.004300304998828254,0.1010954042150431,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015362340340122458,0.16017732886473274,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15874546160570532,0.03385287551035475,3.5279863918501503e-06,0.09223658690262143,0.22525433630878922,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01857737499845439,0.24186252479530318,0.00024783323874784504,0.0023684667442277025 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.063586111355754,0.024137491857559493,0.008687607058071563,0.01616451430087182,0.11100770841063617,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.016443826410412084,0.14418106765829422,0.19156173563047796,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07473748070482097,0.020308031854933066,0.0002579681156490204,0.034839412202697866,0.11463554920694408,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.017872889145824918,0.14175540801129916,0.011189895639464063,0.10693842289820644 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12184773077333012,0.022391269275693737,8.220027428868979e-08,0.07785684077509017,0.16583862077157008,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02166701297512344,0.22464440284526685,8.585602332942363e-06,8.204998533480442e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08275693701056329,0.020978209243273708,9.105937155262718e-05,0.04154220800979645,0.12397166601133013,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.007568055008329134,0.15574732682516443,0.004434535529967819,0.042379504790764376 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14652148898613176,0.026571084097721274,5.581536158676106e-08,0.09431874767277117,0.19872423029949238,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03327886111252018,0.22849350199716176,5.953302043391476e-06,5.689389356873803e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10563113185598826,0.022565899068029138,3.667173253794284e-06,0.061297156350158026,0.14996510736181848,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.025463621052983117,0.18560355856620506,0.0002553510639352546,0.0024403123087502776 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.155936614123789,0.026937237410259635,1.2417206814543716e-08,0.10301451162120583,0.20885871662637218,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.018563339101170254,0.2571703565161408,1.7119636479103883e-06,1.6360714922214022e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08203719078644657,0.021229508789773605,0.00012583921731098684,0.04032874744681977,0.12374563412607337,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.005432540032060691,0.12156188798342882,0.0058415889299100205,0.05582628538384818 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13107007987690306,0.025145046057119706,2.714092303402003e-07,0.08166899673686928,0.18047116301693683,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.010854339468345256,0.1939199956832855,2.505170314465709e-05,0.0002394114933257749 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16087865528024764,0.027534836861957984,9.182321724420606e-09,0.10678248214240985,0.21497482841808543,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.020314687983850683,0.23696319343895667,1.3752692424235993e-06,1.3143029084785522e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047057940931907315,0.01855450661435969,0.011504683799722436,0.010604926616638054,0.08351095524717658,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.021041822314595525,0.09551869672372107,0.22274190244438216,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08076566903755363,0.02037456397120693,8.42552770939499e-05,0.040736888561387546,0.1207944495137197,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008819049238123532,0.1258656403460049,0.004206404965860216,0.04019933050437454 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15334223622282062,0.02431665383696943,6.226196107478156e-10,0.10556864952273128,0.20111582292290997,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.016626657775963668,0.2395557129354698,1.6474514900387202e-07,1.5744191887251496e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06575943590437656,0.0215826763978539,0.002432708395485694,0.023357143671830297,0.10816172813692283,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.04816056081288984,0.06791583079493167,0.074183466974028,0.708948789061601 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047786380144868,0.025910518751922094,0.06572368264981426,-0.0031185849189235212,0.09869134520865952,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015849658447032237,0.21410659069083482,0.5935319600389369,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025253615005635645,0.039673015663301,0.5247087047415155,-0.052689767589349144,0.10319699760062043,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.056275542427119025,0.1724225202195127,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03309862004631576,0.02876243338065754,0.2503728996706527,-0.02340934416738373,0.08960658426001525,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.021395847014828724,0.12408930904826908,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0772820099660561,0.025448884663919705,0.0025142491853484663,0.02728399189730587,0.12728002803480631,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05211834356108214,0.19247966905992,0.07588634993648716,0.725222722639978 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3570046002049033,0.044486788670350406,7.08620045345941e-15,0.2696038636644019,0.4444053367454047,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.044399462676548394,0.4952263920282604,2.8125129599780394e-11,2.687832934384927e-10 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04332593956845938,0.02758541272439645,0.11689575959227116,-0.01086959717283039,0.09752147630974914,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03243742421173477,0.1639739286206714,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14093363529161526,0.035064777934210936,6.723450437900959e-05,0.07204380283396897,0.20982346774926156,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.08208079846084104,0.27096535793565074,0.0034432741661972782,0.03290632198933622 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11251108207764215,0.025661473983998494,1.4141262794564071e-05,0.06209540151378101,0.1629267626415033,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05688453783071951,0.23307680822617868,0.0008253922357591882,0.007888022087821692 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19001131863867488,0.03274422164897249,1.1481997600818297e-08,0.12568055494223823,0.2543420823351115,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028553410974387548,0.25553777375259845,1.6571653991871936e-06,1.5837024757010408e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06874083530807307,0.01919055217265636,0.00037375648481590275,0.031038217415427727,0.10644345320071841,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.005916855002413331,0.16440378797828517,0.015697772362267916,0.15001882712074913 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11832540592398891,0.02028141365934767,9.63466995079013e-09,0.07847963272051686,0.15817117912746095,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023904823334604842,0.14245787189244113,1.416296482766149e-06,1.3535113919127022e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19668379328424387,0.026652050656712205,6.521393057028168e-13,0.1443219814444986,0.24904560512398916,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015097640067063831,0.3058277213157,1.1689901273396441e-09,1.1171682438252157e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11499828382082028,0.026681793228263286,1.9612564526834792e-05,0.06257803839353429,0.16741852924810627,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06447863419408272,0.22834680380662106,0.001120032641827443,0.01070381066728832 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07665000185219624,0.03049522076596994,0.012261957259655235,0.016737725970450243,0.13656227773394225,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02569310045742249,0.17942986561632462,0.23120051479131415,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04743714251383534,0.02374328202171552,0.04625816529544819,0.0007900277498548713,0.0940842572778158,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.012487021741198943,0.1738086739034822,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11126413442464811,0.028117693230124127,8.66704881550536e-05,0.056022855573459644,0.16650541327583657,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.032789172759671664,0.20341831554758621,0.004273231894253513,0.04083797509586717 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.067741708350862,0.029041419889140566,0.020059346250232202,-0.12479778194838245,-0.010685634753341555,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.027981629963576636,0.12134583645044221,0.3249614092537617,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14039805019166213,0.022383961957029498,7.619507947811903e-10,0.09642151647879318,0.18437458390453107,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.017610936038138323,0.24144516906030106,1.884719935443419e-07,1.8011694120748909e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01611438090647083,0.02693503105717566,0.5499274212687666,-0.06903214870901449,0.036803386896072834,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.022162964961066435,0.15139452604784115,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17046985707619747,0.026917443414864132,5.295073457938397e-10,0.11758664274307659,0.22335307140931834,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028765443219770398,0.23252850037614137,1.5011533253255355e-07,1.4346064906321109e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15904604154346624,0.030276210703206765,2.2032861054303087e-07,0.09956404263534321,0.21852804045158927,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014677605875729765,0.23942138732570076,2.082105369631642e-05,0.00019898046568999015 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12799500572500072,0.023649464960927947,9.613142991175058e-08,0.08153220815850688,0.17445780329149457,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.002574514084873422,0.20117305351355022,9.910276501811378e-06,9.470949271870255e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1336074844702463,0.03912539712668913,0.0006892283373501039,0.05673997776726558,0.21047499117322704,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06518370442462469,0.27341493270745715,0.0269512046398282,0.2575644503086796 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04744796751907992,0.020276405769311407,0.019666973542873657,0.007612033040558928,0.08728390199760092,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.006908014887481515,0.16420851935517342,0.3212272345336031,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24336765181887246,0.03360810359716896,1.655489739379345e-12,0.1773396669740202,0.3093956366637247,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0559396847483844,0.3518077481566202,2.1902129251988734e-09,2.093119753556993e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13065976367967605,0.02328964510720264,3.3249286902792035e-08,0.08490388430569376,0.17641564305365834,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028730693391051085,0.20324191509586104,4.060505222067126e-06,3.88050111107727e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1681211234399277,0.02856619527989414,7.220730337417162e-09,0.1119986973838849,0.22424354949597047,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03275670677443124,0.23836296891639133,1.102272258046489e-06,1.053408009134766e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1698815819543985,0.02661450402515975,3.917585614684531e-10,0.11759353590783322,0.2221696280009638,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.006219482080187152,0.23340692802348495,1.2439117843746322e-07,1.188768588478883e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13567129977946787,0.021897424513081784,1.199554042997036e-09,0.09265063930956699,0.17869196024936876,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008561678011220552,0.16753649808536164,2.505805261397492e-07,2.394721732692674e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1635498553483666,0.02825880238024992,1.250867870733214e-08,0.10803134714387536,0.21906836355285786,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.018481247412647225,0.2371941640860519,1.7119636479103883e-06,1.6360714922214022e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20355196078109225,0.02980255951291143,2.4337950063685817e-11,0.1450005182051391,0.2621034033570454,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0066462255212138945,0.23896107908800526,1.3799617686109859e-08,1.3187874127675634e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15268339037443673,0.027384051234213037,4.011220877198527e-08,0.09888345743101454,0.20648332331785893,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.007776010735137999,0.20962505718489044,4.6825104887061625e-06,4.4749325909757076e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17973523418107604,0.027353008587969907,1.2407489267216174e-10,0.12599628901013438,0.2334741793520177,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0015607198982553192,0.2051158592786602,5.274849825154007e-08,5.041013245355577e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07309500837568678,0.022037314208085673,0.0009754836887911453,0.02979951434860638,0.11639050240276717,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02300710535593036,0.16456450911666537,0.035520135420294086,0.33945511069653705 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05887034190720938,0.02226498734586835,0.00844470821919436,0.015127551041506967,0.10261313277291179,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015820063903840734,0.12101771860290067,0.1877705709914981,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24312355715641187,0.039022674643536134,9.777877102272022e-10,0.16645786364236165,0.3197892506704621,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05401434690390098,0.2767995770606142,2.217622526795295e-07,2.119314274591238e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07253579593091306,0.021463937544672036,0.0007822215608170531,0.03036678336485317,0.11470480849697294,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0635939428504822,0.18588817917751482,0.02985228245079696,0.2852891669464157 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1861291509061148,0.029975888377304066,1.1073922968183806e-09,0.1272371786838457,0.24502112312838387,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028887761334536598,0.2761269531998329,2.441800014484529e-07,2.3335538685533225e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03369698658698898,0.021354556641730322,0.11519349674704236,-0.008257131360549196,0.07565110453452717,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0031675164649778943,0.1041675934585393,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15425665643364717,0.03205815549548001,1.9753487155394145e-06,0.09127376901515628,0.21723954385213806,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05448322411735853,0.24952803579544278,0.00015505603276164812,0.0014818232572164937 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14826637690862282,0.027460730550081955,1.0293351550582701e-07,0.0943157963485784,0.20221695746866725,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.020502036444761326,0.22540851051838676,1.0475464693400701e-05,0.00010011082404444728 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053937840396259124,0.0239362927152905,0.024660111480356513,0.006911528183264105,0.10096415260925415,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037930836029803336,0.15620034798932297,0.3709605300190827,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14305955107930846,0.026661662659981475,1.2273815020371226e-07,0.09067885506764442,0.1954402470909725,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.005468440971063374,0.21923389415925393,1.2332853624266682e-05,0.00011786132408261448 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1461720780084374,0.02804174160909066,2.7127073136566087e-07,0.09108001711202107,0.20126413890485373,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.046660521637537686,0.25362637222931617,2.505170314465709e-05,0.0002394114933257749 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022604500314122738,0.02314541454494456,0.3292173248333484,-0.0680770178687924,0.02286801724054693,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.032203824632245914,0.06738105367590394,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0199946683814209,0.02438103720796512,0.412548870874503,-0.06789474553438786,0.027905408771546066,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.01595484161544484,0.07336668273562723,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18911359845027384,0.032883250158122476,1.5328551015596243e-08,0.12450969312093856,0.2537175037796091,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03329449904151218,0.2810592201575116,1.994721933800049e-06,1.906294969979312e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05949282073250712,0.022032657732649855,0.0071607525408295585,0.01620647502552213,0.10277916643949211,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04256032067179257,0.16102605900507255,0.16523852810786346,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0829662172894264,0.020566749261857722,6.326853819535703e-05,0.04255986098778104,0.12337257359107175,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.024232470215765273,0.1588704185472201,0.003282520628723818,0.03137004941570362 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14186324134581776,0.027803085633802536,4.7451890900012854e-07,0.08724005466225007,0.19648642802938546,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.003793341774292939,0.20803419937095774,4.1808121517223276e-05,0.0003995474777817105 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03827627496221169,0.018112242313370268,0.03506364429578189,0.0026921528913000856,0.0738603970331233,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.017461121746930614,0.08360284599616442,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15654498966540603,0.025109846038647927,9.543438632270188e-10,0.10721306205744427,0.2058769172733678,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.02780263227254772,0.21677385950984818,2.217622526795295e-07,2.119314274591238e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04628165358661065,0.03437709278349911,0.1788083233263901,-0.11382042901189718,0.02125712183867589,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.008537784001010202,0.04553841791740043,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1560977200508657,0.023765917690670893,1.2625616865447988e-10,0.10940613423833537,0.20278930586339602,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.005641329067165708,0.2276598249538891,5.274849825154007e-08,5.041013245355577e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10368560471052948,0.036991903942319805,0.005257669369761596,-0.17636155519443214,-0.031009654226626826,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.009297283494463853,0.007868505715475125,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17688241419779424,0.027137297099549873,1.7195735735030283e-10,0.1235672654736553,0.23019756292193316,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.020839587684420985,0.22666188218303518,6.204534102939563e-08,5.929484180768225e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09395735135840937,0.03638815119369217,0.010099344539658455,-0.16544714216444845,-0.022467560552370272,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.010449619979509597,0.01885125124667051,0.20399134085447534,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14351476995081724,0.022683077817508206,5.493001687196314e-10,0.09895057982807556,0.18807896007355893,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.007435882887253127,0.18290196932434752,1.503567151481529e-07,1.4369133107365095e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1586844214341138,0.023066334037999514,1.7731508748929e-11,0.11336726898354749,0.2040015738846801,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.013064768333935226,0.20232401135328942,1.0915019591215567e-08,1.0431151626392854e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11978736141018699,0.021699863216046632,5.408504644414098e-08,0.0771548387085732,0.16241988411180078,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01172082910059716,0.1781456725394589,5.881193132514947e-06,5.620477068015203e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15441008468057624,0.026025493379957545,5.506817872588715e-09,0.10327923531553224,0.20554093404562024,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.00420287151606884,0.2426095419643088,8.921044953593719e-07,8.52557082459982e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03654587277922382,0.03247917363979853,0.26103163243023914,-0.02726416573311255,0.10035591129156018,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037686039418551684,0.18182176414127785,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07314928788486268,0.026991488076335158,0.0069539663238359405,0.020120602095093976,0.12617797367463138,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05470386616543508,0.21307854472713836,0.16187854744460323,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07041874893240677,0.019551006072069325,0.0003470857973862349,0.03200796717270789,0.10882953069210564,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.023810706515017363,0.1420518786978374,0.014845987150114105,0.14187857539985768 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09539275252747578,0.02800737803713134,0.000711483407734849,0.04036820384286828,0.1504173012120833,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04033195486847,0.18837148467034975,0.027604320218629012,0.26380607688121777 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1747462988748656,0.027142101390892563,2.803227800230371e-10,0.1214217114248834,0.2280708863248478,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.007672256469149121,0.30427187274268735,9.296830253864751e-08,8.884697385330084e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12358333126470464,0.028708152965176193,2.0060005137731177e-05,0.06718200878520514,0.17998465374420414,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03787984486483934,0.23697117631233441,0.0011374022913093577,0.01086980711459563 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15088732661173004,0.024575406188940625,1.667425004837874e-09,0.10260538345751566,0.19916926976594443,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.021915779297972636,0.24911822650858895,3.151433259143582e-07,3.0117287368902604e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13315102899391057,0.028696166466078383,4.438591889811354e-06,0.07677325572713248,0.18952880226068866,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03152943402027678,0.23815135868034304,0.00029858934255358075,0.0028535273621570216 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05377150548548542,0.027591629748098524,0.051865348799092666,-0.1079792564698548,0.0004362454988839637,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.025673411912654404,0.06376321905961785,0.5339911008653665,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19053094365125842,0.030896464486429787,1.423145226554833e-09,0.12983036639401183,0.25123152090850503,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06454653872049533,0.33286843365726365,2.824231702098066e-07,2.69903217914148e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01691588111046522,0.02431009776666848,0.4868487212074115,-0.030844825240418428,0.06467658746134887,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04191168405537676,0.1499492827004269,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.25411423697064117,0.03436730406030662,5.914803515077712e-13,0.18659469290914568,0.3216337810321367,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05064345924565052,0.36974847756444995,1.1689901273396441e-09,1.1171682438252157e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030162983697168314,0.02908620577026647,0.30021979356354056,-0.02698107824732015,0.08730704564165678,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.027520108663667706,0.14911373994654506,0.8874303892853559,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15757898373944557,0.027319108776346485,1.3944043602986621e-08,0.10390663965599586,0.21125132782289527,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.040538157048047925,0.26221116680263645,1.876064713906912e-06,1.7928978805899642e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10862388041494228,0.022178707484813348,1.3055300625503785e-06,0.06505059882671768,0.15219716200316688,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.00581403143158095,0.22292961377382023,0.00010574793506658067,0.0010106007924577656 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02608582112190942,0.02734363975651087,0.34053757011941077,-0.07980635986715669,0.027634717623337853,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.04841748871183666,0.02007899703466105,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.4060115955563762,0.05515135215728247,7.363253510579768e-13,0.29765878017404956,0.5143644109387029,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.025054632932434272,0.48047321443114355,1.1689901273396441e-09,1.1171682438252157e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12912750079802612,0.02312515034016928,3.836469822653464e-08,0.08369479520721591,0.17456020638883635,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0038023972135837053,0.22214963684190958,4.54967272797635e-06,4.3479835908109856e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17474431569197763,0.03140797635577072,4.278784382083183e-08,0.11303879931761732,0.23644983206633793,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.07026425718204546,0.3387676469929361,4.922462380431348e-06,4.704247302205326e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010404416556118094,0.021435028261086973,0.627606734142076,-0.052516632649478735,0.031707799537242544,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.01970569380385159,-0.023018567973775418,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13546667664120132,0.021861488696827823,1.1937289605851113e-09,0.09251661728463442,0.17841673599776822,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.014724276794883246,0.16882764334770814,2.505805261397492e-07,2.394721732692674e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031469593935560466,0.021467518571975413,0.14328966967290183,-0.010706454077049767,0.07364564194817069,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.041626304260119484,0.12201143893885026,0.7615412190387651,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17702671446047602,0.02700292442656121,1.3623204018744832e-10,0.1239755603050876,0.23007786861586443,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.010535711737840304,0.20828974002008846,5.407049675039824e-08,5.167352613564788e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009880457886404152,0.02049860189738874,0.6300089743081727,-0.05015292882509337,0.03039201305228506,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03588656988541791,0.09066665863026105,0.96007126858481,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1560504435440058,0.02612567606990258,4.380835273501202e-09,0.10472277078146536,0.20737811630654623,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.016625659962536506,0.22836980586742003,7.361203831817048e-07,7.034878195204077e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11755537116579891,0.02515946426922277,3.8174550106651245e-06,0.06812596136081428,0.16698478097078354,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023546412041008703,0.2006843857820207,0.00026350398151878053,0.0025182272577804073 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12081835781057858,0.0340950192733506,0.0004311578582067843,0.05383375663077934,0.1878029589903778,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06752432792455629,0.25159670942272827,0.017682532570199628,0.16898657564190503 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1267281902919188,0.02478181968381854,4.4822528037610414e-07,0.07804071794525336,0.17541566263858427,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03487925715477103,0.21829322429310716,3.997766601826421e-05,0.0003820543723452591 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04120079835593627,0.020251894280941023,0.04242843630612226,0.0014130202447617812,0.08098857646711076,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014442790039072027,0.11035889381956443,0.4945623016123326,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14166904086528556,0.0314871634937633,8.460076271839962e-06,0.07980794989469239,0.20353013183587873,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05539932874696903,0.27243741648187747,0.0005246569175458251,0.005013986290194933 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09620986956555859,0.025043903396361394,0.00013767668249333833,0.04700749582465558,0.1454122433064616,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02147415347815302,0.21155032957936884,0.006280905204782298,0.06002469715657909 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02881963215166254,0.02656557056183956,0.2785031116698117,-0.023372277022283026,0.08101154132560812,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.013117328195169486,0.15899441591278268,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1931758213234013,0.0341331868961771,2.5406877295780022e-08,0.12611623432316546,0.2602354083236371,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03154075270273502,0.3026079701652336,3.201266539268283e-06,3.059352884211042e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09660699967685489,0.032126714166080116,0.0027685085433724987,0.03348941882496992,0.15972458052873986,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.013574879347874979,0.19525056535912622,0.08109380375384094,0.7749887719835561 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08157895394544458,0.029666102808347368,0.006173772870049127,0.02329560031996982,0.13986230757091933,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.043651851862184746,0.20881139200703977,0.15172572458962838,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023940434564693684,0.024731764893672164,0.3335032546018709,-0.024648697900471424,0.0725295670298588,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0440687285786995,0.12047124586488119,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16015158391060758,0.024876927214351863,2.8108330321586547e-10,0.11127725905182315,0.209025908769392,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.051133674108332396,0.26455331133194726,9.296830253864751e-08,8.884697385330084e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06621565842046438,0.024607217705535502,0.007360663371827598,0.017871216936656796,0.11456009990427196,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.012955134747194081,0.09953414442491258,0.1683831292379466,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3617142657207488,0.06788491411903447,1.4923943972867066e-07,-0.4950840069703943,-0.22834452447110326,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.13858426837740728,-0.06480972726155247,1.4808283407077347e-05,0.00014151825221654844 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1780876088242444,0.025891516576369695,1.7875441507407705e-11,0.1272199762852044,0.2289552413632844,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02407577197610953,0.2630299621115005,1.0915019591215567e-08,1.0431151626392854e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17265747164085057,0.025352649980926397,2.7610118630205152e-11,0.1228485205384009,0.22246642274330025,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02770869678644329,0.256126680754336,1.4611274779104567e-08,1.3963550079048083e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015977423570321225,0.028695233104086507,0.5779112482223536,-0.04039851597170426,0.07235336311234672,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.006076467267769108,0.13312229001069062,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13839881551607372,0.02245995651216986,1.4632770257097785e-09,0.09427297949816421,0.18252465153398323,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014312703323714737,0.23471062798663314,2.8330470805083466e-07,2.707456767670453e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07392904531428178,0.02500999762820237,0.0032616348655423854,0.024793284363347247,0.12306480626521632,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01458982922961357,0.17831629741139257,0.09313258116070308,0.8900396992658464 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03583872900328238,0.027500814496084016,0.19310096429327017,-0.01819060227149647,0.08986806027806124,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.011435300119506308,0.15155389405117572,0.8140390093255331,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12629517777711963,0.027539470865358625,5.697503886830676e-06,0.07218990046875273,0.18040045508548652,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.011309874400878332,0.1688581704964725,0.00037377508969968514,0.003572054637413435 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16933856841988526,0.030327409836010868,3.8401117759437566e-08,0.10975598140344828,0.22892115543632224,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.009803307378770049,0.22057892535406415,4.54967272797635e-06,4.3479835908109856e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13460834837284003,0.024417060727923948,5.6248129661673055e-08,0.08663749779991431,0.18257919894576574,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03922505596118087,0.24937858815788294,5.953302043391476e-06,5.689389356873803e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012073084838746303,0.027464379679816086,0.6604205466202149,-0.06603083464242523,0.04188466496493262,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01118300281632562,0.0850324570804132,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15704235755532084,0.03505804185489466,9.249734921985309e-06,0.08816575910065014,0.22591895600999154,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06593593739954516,0.31636324828816326,0.0005639715767912388,0.005389704508840115 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06379749558192183,0.0260185764507807,0.014542046070364651,0.01268023552558551,0.11491475563825815,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02164663230578478,0.2032332284197867,0.262949343295113,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1016552336698751,0.028677354185719872,0.0004292262050341365,0.04531441985124967,0.15799604748850052,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.057279525149231326,0.24419778403328457,0.017682532570199628,0.16898657564190503 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.128230095645278,0.029156751941846235,1.3318998800308525e-05,0.07094743553399732,0.1855127557565587,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03460894368237648,0.2743196263771279,0.0007890015856481274,0.007540247733484313 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06033822490682293,0.019833532073810535,0.0024697455910336103,0.02137237991639726,0.0993040698972486,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03819256220010499,0.18329066282433512,0.07482763550238472,0.7151049113993448 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021824360484881494,0.04172732124472496,0.6011860954417536,-0.10380372378924443,0.06015500281948144,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.020259181379720742,0.10935066937374784,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20702386474081946,0.03739971102675407,4.9828772205892443e-08,0.1335467182027331,0.2805010112789058,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0555356583945126,0.3237139083922926,5.5709970953573825e-06,5.3240321674397756e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1820264439294669,0.025855600505990728,6.2618830915316045e-12,0.1312293737101309,0.2328235141488029,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.00810476054602821,0.23204083555730243,6.213353497572234e-09,5.937912607478555e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09151555134244789,0.024810928141957074,0.00024988802467748936,0.04277089121583908,0.1402602114690567,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015077797317815084,0.14451347267953085,0.010898962307087421,0.1041580616924099 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22276461661259792,0.032336394522662196,1.668243339270447e-11,0.15923508834551184,0.28629414487968396,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.018362315138325716,0.29652983920606596,1.0915019591215567e-08,1.0431151626392854e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018548105197563582,0.026410012249594838,0.4828054142252769,-0.07043439754746882,0.033338187152341645,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028411747401612633,0.05196323533029206,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2102009260100256,0.03318450794994474,5.255565271490306e-10,0.14500515613661322,0.27539669588343796,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.02653206355345131,0.29309105026976245,1.5011533253255355e-07,1.4346064906321109e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1117901178736938,0.024736233890366843,7.726307962772605e-06,0.0631922054175609,0.1603880303298267,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.005770937583454076,0.16071812057849882,0.0004906514608679115,0.0046890065026941145 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20340258043419757,0.0291977152261124,1.0120641561591536e-11,0.14603944202086386,0.26076571884753125,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.008027300794031893,0.2771449617717523,8.926405857323734e-09,8.53069407693986e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14827130048725798,0.026854086967977066,5.374393138116452e-08,0.0955125590659391,0.20103004190857687,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0038700962344010675,0.19492479154134115,5.881193132514947e-06,5.620477068015203e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09835662735555158,0.020235345710834605,1.5619173863568052e-06,0.05860136130603005,0.1381118934050731,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.011609049190285076,0.16687223542295496,0.0001239850021290032,0.0011848868852669117 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17653275674371574,0.028166025853374972,7.835192475388363e-10,0.1211965214572053,0.23186899203022618,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.004263458849175649,0.22055445070334928,1.884719935443419e-07,1.8011694120748909e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0634277649083222,0.018917466300236926,0.000859457892347245,0.02626166374573636,0.10059386607090806,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0002248905057476337,0.11770683716496634,0.032181022403077506,0.3075442250685532 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09007097266152368,0.020694468158791588,1.628665454284868e-05,0.04941369409743145,0.1307282512256159,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.00356254755873163,0.12408721485548263,0.0009368366939212523,0.008953062815687416 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.40032548200367085,0.04981290689904846,6.51479360072965e-15,0.30246081515928913,0.49819014884805257,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.041172032198420666,0.4569069895235121,2.8125129599780394e-11,2.687832934384927e-10 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04033412184456012,0.02552394033443901,0.11467279647220359,-0.009811353954473537,0.09047959764359377,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008944616935060245,0.07758395816553484,0.7133798263294295,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10450117815307448,0.020615322573194428,5.608108336805362e-07,0.0639993925495189,0.14500296375663008,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01597336700829967,0.15158600460537774,4.78679182554419e-05,0.0004574591086983892 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1155900033424464,0.02700662550509388,2.2339024261609795e-05,0.06253157788248831,0.1686484288024045,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01184058832981587,0.16498192064271516,0.0012553410573189218,0.011996911963647416 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06255238711159358,0.020976624194475817,0.0030011670982703397,0.021340772168652204,0.10376400205453495,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01751014690564301,0.13635593961151504,0.08726470485739911,0.8339621934646272 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10306926723368035,0.023248182326262433,1.1373102728640516e-05,0.05739484749527761,0.14874368697208307,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0016191433420533067,0.14835442224995113,0.0006839370413632456,0.006536177898487877 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1483666392461669,0.02460365254602412,3.1526297827278816e-09,0.10002920203433516,0.19670407645799862,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008628472081577064,0.17997777963697506,5.68763073074862e-07,5.435495378782297e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003027552510631501,0.026014583532294494,0.9073981306977477,-0.054136967900560745,0.04808186287929775,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01737428665855382,0.12081189476325044,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11083347076900228,0.019128774706196304,1.2062808625669979e-08,0.07325222365252658,0.148414717885478,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.023438134319167924,0.1594110341225143,1.7099031226887196e-06,1.634102311054331e-05 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09149862202709878,0.18991369871300767,0.63165109943732,-0.28813345239466215,0.47113069644885974,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04588315067456916,0.14149601543986504,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13817451774354003,0.16504197809148238,0.4056910873509071,-0.19173969557618012,0.4680887310632602,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08281781378715365,0.18706109838634935,0.9237532919369174,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057196368774888554,0.14759721623152153,0.699700978217477,-0.2378462624653397,0.35223900001511677,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03633732307251834,0.08788131021598179,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10647846165949924,0.18496865908811955,0.5669308040509662,-0.2632686194015089,0.47622554272050743,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008687282207159133,0.2875352647116979,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05446195349539348,0.1453479596268539,0.7091618488883549,-0.23608447785760492,0.34500838484839186,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03393222484249799,0.14992852166551054,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08708748266740227,0.13235724013499786,0.5129912441820503,-0.1774908704356056,0.3516658357704101,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03636333634392273,0.09069277091117003,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11654806271599971,0.17182500955735883,0.5001084798353415,-0.22692523730314862,0.46002136273514804,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06860483295398732,0.18678672431467308,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08479262102749413,0.1578514304898364,0.593074748149331,-0.2307478924446631,0.40033313449965136,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04150270980443933,0.12000725185582715,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03649958086768012,0.13164626645941904,0.7825066827369225,-0.22665755610848515,0.2996567178438454,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01626289475411384,0.04872110495301551,0.9718034799423088,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06535801427507294,0.175187721052025,0.7103657393136906,-0.2848372502419138,0.41555327879205967,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.052347918949252205,0.2034734522770872,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010518650873767502,0.13070502931814917,0.9361176954076472,-0.25075697986622536,0.2717942816137604,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06317727037854236,0.17592787945074553,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11525543647958175,0.16517579438847824,0.4879269694079883,-0.214926271806348,0.4454371447655115,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06329419593949849,0.21167926592486044,0.9404802865694325,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07697478949968241,0.16716166786886538,0.6467819883846384,-0.2571766233099732,0.411126202309338,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011501789242347453,0.17329157305298928,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03059822289307018,0.12669116400770392,0.8099505119136925,-0.2226538054181343,0.28385025120427465,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.020379643326189995,0.09493713439697224,0.9747331744048557,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07281150371991353,0.2124190425469928,0.7329287112157901,-0.35180811200702644,0.4974311194468535,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14725835779355229,0.002098484862113868,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07593500309832538,0.21538069752981553,0.7256127147571783,-0.35460487658255724,0.506474882779208,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10479714003672935,-0.15226860491290073,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006818969820881697,0.10581269481688733,0.9488242068081967,-0.2046975932586215,0.2183355329003849,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06953884540661666,-0.0034852056370334806,0.993730344541434,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044645234427023804,0.13906032652454725,0.749252687471603,-0.23333239744490739,0.322622866298955,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06899132145496113,0.21144715277603346,0.964192424193284,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04783333077162272,0.1212879602436371,0.6946551329801143,-0.19461784711448465,0.2902845086577301,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01765945755602184,0.12667938123435957,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009964966110619273,0.12605270383240766,0.9372443016731292,-0.24201079849540783,0.26194073071664636,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03589272810124787,0.15122537199108008,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07623698360720686,0.2108708048497802,0.7189294101418907,-0.3452877490614078,0.49776171627582155,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11353186263249569,0.12197969220835152,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1084961909288863,0.1333062728222304,0.41882481221530665,-0.15797925148463304,0.37497163334240563,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0009331258791751011,0.22460086115228936,0.9275566244234728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03998255643572135,0.07834254679715053,0.611614636936378,-0.1166219631836371,0.1965870760550798,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09611489595913951,-0.021461974963071867,0.9549530254352627,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13395616847102074,0.1559556113801318,0.39368360569119065,-0.1777946565993894,0.44570699354143084,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0536600402448876,0.21787333978769885,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02352702104668372,0.1214569194107544,0.8470387679021594,-0.2192619014020328,0.2663159434954002,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02892016272358628,0.09975363621405732,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09288005288308387,0.1440231328346394,0.5213732970345226,-0.19501808744727506,0.3807781932134428,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11192082294954528,0.2592261304058123,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028600821790168218,0.12147481243500921,0.8146381530409327,-0.21422386830438728,0.2714255118847237,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10469772119568004,0.02632519627262702,0.9770888048613304,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10064876981815019,0.13866562781280842,0.47066927318168894,-0.1765398705712053,0.37783741020750566,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21776064212187304,0.31508959794193564,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05464899379058771,0.13922433759499267,0.6960167937391498,-0.22365649153964204,0.33295447912081744,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05654327304708454,0.09828628142688145,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04234149679277459,0.09599286098738964,0.660682166548678,-0.14954549815956192,0.23422849174511107,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11548097552031845,0.19064110247437857,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006349913641325946,0.13007575603699037,0.9612220216861522,-0.2663676450158522,0.25366781773320035,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0390367262911659,0.07763158921262028,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1145432168070949,0.16384661861458685,0.48711137969641916,-0.21298150696569518,0.44206794057988497,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14569317519638367,0.1076636973240833,0.9402561783874069,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15679800149208384,0.13883791928338726,0.2630966362640389,-0.12073504463958656,0.43433104762375424,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07273970783241707,0.18530824798403836,0.8670850705749964,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010575369592179891,0.13439720621781717,0.9375346657293828,-0.2580808176060979,0.27923155679045775,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008683071439127025,0.06665388093187499,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11099811046741058,0.17628070148791306,0.5312262148920477,-0.2413819908095911,0.4633782117444123,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12207772695373936,0.10188609734522247,0.9462574637850627,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12673512979253113,0.07803541046963602,0.10943418341039132,-0.28272569264134184,0.02925543305627959,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3007448708563821,0.09277574534051622,0.6985162532376802,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03093961262809769,0.15250723804955602,0.8398985501977543,-0.3357972376305893,0.2739180123743939,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0010647021297218848,0.00320548597713611,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17522368367609684,0.08491149109818745,0.04324781240617783,-0.3449593358502068,-0.005488031501986845,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.47276398954806825,0.11884197818709111,0.4971708399879019,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04845342266867503,0.10343685094288645,0.6411164405260158,-0.15831389617778216,0.2552207415151322,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06739761220134707,0.029020400066418206,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02953421831705566,0.08844450317808644,0.7395597048709843,-0.14726382437410726,0.20633226100821858,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.015326859575081236,0.09551759199296918,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046329449619205564,0.09690395051990643,0.6342629345272621,-0.14737878735809923,0.24003768659651037,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0691269349992647,0.04867758900800954,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02571670605761751,0.10350717978739762,0.8046047793265227,-0.1811911981458434,0.2326246102610784,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.009980381033582906,0.07969403110309113,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00925520182843752,0.10778387483865486,0.9318479328173929,-0.20620169396952417,0.22471209762639924,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012206110987827763,0.02315243101650118,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010996767518901307,0.10940125980756672,0.9202576406681486,-0.20769323476399315,0.22968676980179575,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006657023916658735,0.0995862770171453,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019707884619250392,0.08053839514993583,0.8074954530631964,-0.14128607331305054,0.1807018425515513,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04399603594306499,0.0846442803425286,0.9744449538485335,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03516369106682012,0.13053719990787452,0.7885342333217584,-0.29610383559595344,0.2257764534623132,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0290689780177431,-0.0060714675213970415,0.9726336318937702,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008593383229694338,0.12049771742399631,0.9433760218109284,-0.23227812176841095,0.2494648882277996,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.046054762244615355,0.04781234932541188,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025517096387387934,0.10101847770397562,0.8014142226741688,-0.17641596323693073,0.22745015601170662,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027803958732854298,0.0034497347138454015,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015735806769725382,0.07457249504095946,0.8335687331556094,-0.1648041003107162,0.13333248677126544,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03049311573077441,-0.02763750255524334,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011525731664200595,0.1380770945543821,0.9337442468726291,-0.2644864475047338,0.28753791083313507,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.021728262529866923,0.07904282995111585,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0016549107794746713,0.06259849159137126,0.9789937628435765,-0.12347769092092993,0.12678751247987927,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.26484960229430016,-0.1636836835632361,0.9984157213799838,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025735819595793,0.11321530346064718,0.8209247855863082,-0.20057834731433122,0.2520499865059172,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2751052093750703,0.2368704938513591,0.9791887224619256,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19104127036762472,0.1970510877588834,0.3360621816793471,-0.2028582414628278,0.5849407821980772,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16521601669420916,0.15247042331194954,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03380819437489365,0.13737861721486908,0.8064215843850573,-0.3084241372368483,0.24080774848706102,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2490081523879538,0.2042183579686002,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06240906252964748,0.13925411489944764,0.6555951176048368,-0.21595594678404176,0.34077407184333675,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06000886662665863,0.1440274619323024,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035752061800216714,0.15273223325344762,0.8156915841361727,-0.2695553222063233,0.34105944580675673,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026914609770084412,0.2004137186176381,0.977649408210028,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11143451823911348,0.18518536497486443,0.5495375168398997,-0.25874575171707115,0.4816147881952981,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09044285811480782,0.061298284565918716,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07854155485628234,0.1553145921684517,0.6148651724038612,-0.38901100078067274,0.23192789106810807,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12402827734346342,0.22535354884592684,0.9558949742541814,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10434448508610548,0.13225794017423229,0.43314966516653564,-0.16003537022368947,0.36872434039590046,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07634060892149748,0.10710234531962967,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018693687338133275,0.1300205332171525,0.8861445313205227,-0.27860102986871343,0.2412136551924469,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03248279164209565,0.07884037016505503,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01599428363416271,0.09983034491685813,0.8732328422937181,-0.1835637323902546,0.21555229965858005,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019364859430288366,0.010155553064347749,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019026009232660755,0.1367415902155445,0.8897917421466432,-0.25431653480206284,0.2923685532673843,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11192482619852641,0.00829888401775856,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06553231111950567,0.12475682345245596,0.6012618375251753,-0.18385302551751562,0.314917647756527,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08587883403475186,0.07068114222919286,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006983195706981897,0.13655710476486013,0.9593803138957238,-0.27995695858048036,0.26599056716651653,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.004874691399172577,0.14145220392020094,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014113268842845948,0.16082828230492638,0.930355300062069,-0.30737788661810517,0.3356044243037971,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.018584859085720242,0.018872913281172465,0.9916960348989801,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12877373587253046,0.13356740690032812,0.3387360071519846,-0.13822370612523302,0.3957711778702939,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004166643563753691,0.1541776784241659,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05091896669623194,0.15003466220452208,0.7354693866105967,-0.24899604961833208,0.35083398301079594,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.043592700641488,0.0598884092480974,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07914065433431036,0.13548058669218346,0.5612405054611965,-0.1916811795743358,0.3499624882429565,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.15512920570969224,0.2104575086806191,0.9509691818071948,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02241416312832128,0.12862924170845735,0.8622335772007077,-0.23471202730448687,0.27954035356112944,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026150992229229446,0.05764054762301518,0.9846655352926511,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08412420239434268,0.12403545475964316,0.5001513165521299,-0.1638191387724662,0.33206754356115153,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.015857897986527092,0.09784002380266951,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012850578178126855,0.10482254222323721,0.9028254051147252,-0.196686698069153,0.2223878544254067,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07921541130756356,0.12457490924324534,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013253456485087106,0.10366259790144142,0.8986799979851422,-0.19396512410157837,0.22047203707175259,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.084177648385162,0.10999099869142388,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03588546400705237,0.12721412459235626,0.778816221521654,-0.21841194761740326,0.290182875631508,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0034901786433625087,0.05894331179906524,0.9700679690002965,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10522995713669549,0.19786780794805342,0.596751551060954,-0.2903021550892941,0.5007620693626851,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08663555830262502,0.2349604744856357,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031536226803426194,0.10012119764527472,0.7538341072737347,-0.16860319554074735,0.23167564914759972,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0027578305691481793,0.028754543688205642,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04680118108110886,0.13822277829631702,0.7360608297312112,-0.2295022157384483,0.32310457790066605,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04459434570083498,0.13995565417507233,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02981377583476107,0.12521569841416375,0.8125891941142971,-0.22048883878059383,0.280116390450116,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.018142966838125985,0.03132292739455487,0.9764147093858516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03399964673261579,0.10395186922885737,0.7447158656028089,-0.1737971789982486,0.24179647246348018,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.035817039753483576,0.12074721896639669,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00806997100141488,0.1125320902880744,0.9430614459141817,-0.21687847223667434,0.2330184142395041,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06020809748520213,0.026422783528539828,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013689829898279184,0.10305903866417171,0.8947541981363123,-0.21970191276080012,0.19232225296424174,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00634244471994182,0.02311227950011806,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09360946587317781,0.13718191265103533,0.49754366567212127,-0.18061327016840273,0.36783220191475835,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00929678963451541,0.1934036986465453,0.9438001947036577,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02730875753442854,0.0830539854484967,0.7434094079951951,-0.13871379375322104,0.19333130882207814,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09545069622942183,-0.0395813367913883,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009509563688456993,0.12080241335842883,0.9375088726846712,-0.23197101980393475,0.2509901471808487,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00032432850387109765,0.07275813254444499,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0018492316492028265,0.06117759813385683,0.9759828954763518,-0.124141507799297,0.12044304450089136,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04574714057559269,-0.019563830800842934,0.998018743752871,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09357958831878062,0.10616628365588282,0.3814821899598251,-0.11864378877861546,0.3058029654161767,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.036389381094186164,0.15603672157472276,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009927517118874369,0.09860206252856582,0.9201272626358505,-0.1871751973964729,0.20703023163422166,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11065622808339164,0.127359214410183,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01774081416698574,0.18796581727371525,0.9251091350019329,-0.35799750073907166,0.39347912907304317,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09608663419199716,-0.00998511911850972,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000581433597972632,0.10331965972051488,0.995527979586782,-0.20595162333291744,0.20711449052886272,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04154534404518989,0.16679079281314807,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03805046034522409,0.16092876388487828,0.8138684428249955,-0.28364155493203747,0.3597424756224856,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03230227890876076,0.16767682102527146,0.9767897942462676,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07132414804257042,0.1278352866522615,0.5788959830376181,-0.18421494884709755,0.3268632449322384,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.045446210242107175,0.021360651229988037,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09843677008213418,0.18100420282799057,0.5885040476049687,-0.26338547583435146,0.46025901599861985,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0913172459985694,0.1298033599161212,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008927784423009507,0.12058902953979768,0.9412210441317161,-0.24998181973976177,0.23212625089374275,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006402769086916728,0.05840279417094161,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07643295260980004,0.11700473358351662,0.5160125458738211,-0.1574561771817285,0.3103220824013286,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007942404106704756,0.1952510199460072,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01967345208122747,0.09623330110542694,0.8386832263753664,-0.1726941758186177,0.21204107998107266,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08989913317427607,0.12018069945781186,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01957485817107095,0.13000551380778178,0.8808041644597221,-0.24030246098797442,0.27945217733011635,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010861406610999862,0.1877293141471268,0.9867875051416815,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005930777285821793,0.07015962274368258,0.93290532974701,-0.1343163102246069,0.14617786479625047,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21315582067234512,0.16821136395431407,0.9919986667747693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040903271967087776,0.12080530926352533,0.7360638498114551,-0.2005831003571079,0.28238964429128344,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03538167589577699,0.10416559824224333,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01899782274876913,0.1393207695761492,0.8919782609710243,-0.2595004273651236,0.2974960728626619,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03240628101034207,0.14579838041058069,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02610681300194243,0.1255899062632701,0.8360090699670457,-0.22494383244522645,0.2771574584491113,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0167510606412801,0.13483337862834452,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01309199147796836,0.09098834387782453,0.8860567865256839,-0.194975099271778,0.1687911163158413,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07892420640377339,0.07534436030450686,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001540874132035895,0.08228732477893265,0.9851201901384119,-0.1629491443139254,0.16603089257799722,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06836396348987839,0.0698120510228961,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062424829337216235,0.09276248953346325,0.503477634161005,-0.24785440376371617,0.12300474508928369,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.029521549977803426,-0.04724211887421787,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014892027950981985,0.08578961547298339,0.9862061369670132,-0.17298020058283803,0.17000179499264162,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007735471900123061,0.008421889335747643,0.9990098172080826,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051250697787207825,0.15076731574424435,0.735056379587248,-0.2501288720851147,0.3526302676595303,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13957867868475518,-0.018521131943806533,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009342847323718595,0.09149002313973931,0.9189919740935428,-0.1922287976727822,0.173543103025345,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010331029916221465,0.048461087097804334,0.9901822239590808,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07930375849056279,0.12022307073462772,0.5119288185256288,-0.16101873559824717,0.3196262525793727,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05681442447223745,0.08045840442487358,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04028574585072606,0.08660182488302806,0.6434297933788911,-0.21340032711501167,0.13282883541355955,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0315724809239452,-0.024645021052756146,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02437055602674228,0.15690573064156588,0.8770738294074657,-0.2892795303850594,0.3380206424385439,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09258218865797718,0.014147660675855631,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025665740609346403,0.08496234527096407,0.7635992912643954,-0.14417156760766633,0.19550304882635913,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07410719299703496,-0.03180869621442722,0.9681057644104086,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0015754441349337574,0.06848537088796486,0.98172088246378,-0.13532486160357493,0.13847574987344247,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07383932925954904,-0.04325477403047737,0.9987056728178246,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028120901582840745,0.09654456362721354,0.77181418325253,-0.22111073439805737,0.16486893123237586,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03989600199764608,0.031259767605139085,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05031790208328699,0.1217422380084142,0.6808018666037288,-0.1930413641154314,0.2936771682820054,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01665999812886729,0.10495568363820588,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11244345047844462,0.17678989282874333,0.5270986871777599,-0.24095450978559685,0.4658414107424861,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.031639424756681765,0.23595697859916337,0.9448126253726593,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11806297392259132,0.13477327409656356,0.3844050497597715,-0.15134496225377167,0.3874709100989543,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0315701888039072,0.2254974751515618,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013382652923106928,0.07385542293156397,0.8568011241933307,-0.16101753974175712,0.13425223389554328,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02338863759126552,0.004653810639946933,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09005706864394065,0.11511610057744852,0.4370071022226062,-0.14005673756232861,0.3201708748502099,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019815339624401827,0.1640961160641495,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05923101041264739,0.1057622332402676,0.577470583197026,-0.15218468141248834,0.2706467022377831,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03197805032157495,0.1427468132974035,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07635731835741699,0.12874509010118854,0.5552788405356152,-0.18100044971275486,0.33371508642758885,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013928912473136892,0.16716266625493367,0.9497529489704187,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03597645741487046,0.11002264371033822,0.7447758206194247,-0.18395567359080725,0.2559085884205482,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05590563539651765,0.06564795320909214,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11323989672221556,0.12301861135212867,0.3608740220025174,-0.1326708034356887,0.3591505968801198,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028796221308248413,0.12916269544816686,0.9134053709502656,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03311097079806658,0.08226763118255484,0.688716082768619,-0.13133968070966756,0.1975616223058007,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022481579364450728,0.08849577470685699,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06523091079358424,0.17310065907120506,0.7075806769891553,-0.28079237626946024,0.4112541978566287,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.024089118697926733,0.19936965509168275,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07738080014304645,0.11773095596687211,0.5134412281768677,-0.15796002750784177,0.3127216277939347,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.13425015217304043,0.23996734661085967,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08204828217062117,0.14482815309560412,0.5730843919596718,-0.207459070732041,0.3715556350732833,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11838126635007153,0.10886420345443515,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06008539226402517,0.1316224351305043,0.6496270656405965,-0.20302410656442652,0.32319489109247684,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06013998917308348,0.15833752385928573,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03780866974259655,0.11055197692020512,0.7335081980847076,-0.18318158327262493,0.258798922757818,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.049074170742366786,0.18434509448089317,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022051023097208192,0.11842952287139118,0.8528994682177081,-0.21468621989855585,0.25878826609297223,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01180087434428867,0.09316083207940844,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049371056794161705,0.088679553739219,0.5797122946738096,-0.12789684527376793,0.22663895886209134,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10051322652806632,0.004645581803517929,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,5.1161586281195555e-05,0.0838083000289195,0.999514883671784,-0.16747924306251658,0.16758156623507894,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0785518116111342,-0.035172236535148914,0.999766777543677,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07184125302283402,0.10100868150153404,0.47960390088957217,-0.13007222427182885,0.27375473031749686,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03899982300107029,0.10205528439490529,0.9384017168502401,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023726285867654077,0.15281824083735168,0.8771221274767401,-0.28175302484935905,0.3292055965846672,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02517056625074004,0.2557467656431591,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04029001566044644,0.08307495751368972,0.6293969903918998,-0.1257744581881774,0.20635448950907026,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11359638350131962,-0.0787965438131165,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0005356792512591555,0.073742522065883,0.9942273941254153,-0.14794488045516468,0.14687352195264636,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04340559410385001,0.040801041496497485,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03915881495407806,0.11876268212970088,0.742720526157997,-0.19824440390968304,0.27656203381783917,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0541083965182269,0.15453947657239314,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010558925873296182,0.09055577855384164,0.9075528486198825,-0.17045949615861533,0.1915773479052077,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03319069291491688,0.03072400991755846,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022854004396787347,0.09763277121637548,0.8156931255448495,-0.21801913318735822,0.17231112439378354,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10914506015974446,0.12261036960081977,0.977649408210028,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03653593103328181,0.08319191501073493,0.6620605250531628,-0.1297623375206389,0.20283419958720253,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0095314896867061,0.0467812735934105,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01809824804069067,0.11593724287527482,0.8764583517386496,-0.21365699823036471,0.24985349431174603,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02900885093714904,0.07349325612492667,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055092050956649666,0.17347113822701438,0.751865921677625,-0.2916718133865122,0.4018559152998115,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.001977173943731422,0.20345462178424492,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040906834662493924,0.1399839152645844,0.7710900670727614,-0.23891702479422425,0.32073069411921207,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03222643568671117,0.09561707634383054,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0059905460427694835,0.11919312364598121,0.9600774376850822,-0.23227311315178464,0.24425420523732363,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020379009914985816,0.021675247842797778,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06707150142384458,0.17740335813032274,0.7066673890993043,-0.2875527585047424,0.4216957613524316,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08042441298752917,0.1694664543751398,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08856229064356448,0.12146891446722774,0.46868934969145637,-0.15425060958138748,0.3313751908685164,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.012281785251334729,0.17364405868189364,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06963656874184171,0.1458176792105223,0.634643328703549,-0.22184881867990258,0.361121956163586,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05867369980488363,0.07992134749527513,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010047972610883082,0.12005787707719688,0.9335703726048694,-0.22994430406192806,0.2500402492836942,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10806804894214973,0.1836143829551966,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20091911289611922,0.15562022028809797,0.20146705626284342,-0.11016127493424852,0.5119995007264869,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2762613266773137,0.08361985432363318,0.8177134279159035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11649728326683481,0.15543528324709366,0.4563960315851505,-0.19421342068612088,0.4272079872197905,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11185197906493521,0.0552389693011885,0.9353936944091839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019918168428555726,0.129741354406741,0.8784851415374846,-0.23943110361185257,0.279267440468964,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04868087625552829,0.18100042866158048,0.986191362849829,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03877264411711519,0.1342830707315381,0.7737449703859591,-0.22965538949500802,0.30720067772923837,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.023353624157600675,0.15729330080359533,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11003348101006438,0.12919780562576844,0.3976767322035254,-0.14822925249906155,0.3682962145191903,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11755009902533098,0.08984345237605074,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05524735455278294,0.2660311128443388,0.8361653089068853,-0.4765412626677429,0.5870359717733088,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7473462713246929,0.5288319202041329,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020602452638574416,0.09744609669672151,0.8332497927667956,-0.1741895191042523,0.2153944243814011,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09483671253333747,0.19205837688807065,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008004052528259607,0.0905570651064736,0.929854102197085,-0.17301694128571835,0.18902504634223757,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09802159009403352,0.15068551176954972,0.9916960348989801,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07833217071012674,0.12939132226482639,0.5471298043694266,-0.18031739704854802,0.33698173846880153,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12337958777354958,0.02078691746773777,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0009691002935928012,0.0911258390253438,0.9915490055439553,-0.18312705697102374,0.18118885638383816,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02999984100140603,0.12169851455754345,0.9992761255456871,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10854219528498871,0.1324178603060726,0.4155303120661227,-0.15615733581335528,0.3732417263833327,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.169729581692687,0.03054421882514211,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07515287135202448,0.13593642799900377,0.5823519471134966,-0.19658017634524272,0.34688591904929167,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12654732381539216,0.02452528634361268,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012057451975532998,0.11028039427029768,0.9132902916456342,-0.23250481900906905,0.20838991505800308,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017799622188880513,0.09266806629458499,0.9895309118568834,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039617250767677865,0.08383272619067549,0.63817575307758,-0.12796198108274057,0.20719648261809628,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05935316051851956,-0.02853422923557025,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0694004069336451,0.1307045132171584,0.5973353668113363,-0.1918741921351673,0.33067500600245747,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.029745248558531858,0.16075984956683848,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010308976912760144,0.13728665178054114,0.9403841621564651,-0.26412312966542134,0.2847410834909417,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06908299079544566,-0.010035768736842508,0.992787535469879,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12539726886322164,0.17844304066051533,0.4848543256955766,-0.23130528682997756,0.48209982455642086,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02469629376379764,0.2626121406726932,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11735801621483181,0.14005589456774353,0.4052848297086863,-0.1626097278187174,0.39732576024838107,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08276146756971345,0.12346770879474094,0.9237532919369174,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09012666052083346,0.10799072873407914,0.40715977077366383,-0.1257437303222688,0.30599705136393573,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0763451727265822,0.06471930766899596,0.9239663408808872,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049284136797271866,0.1351255028565789,0.7165551405036599,-0.22082789463784178,0.3193961682323855,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0014639688028437847,0.2199826213315569,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009092383323136902,0.09845131410856373,0.9267144705136323,-0.20589375604066218,0.1877089893943884,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.061792453965928654,0.090522146612629,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06331589871156819,0.18349263534036428,0.7312174467155823,-0.30348065291921233,0.4301124503423487,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.21923403863720978,-0.027138287346203042,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07218929686549372,0.201633920650222,0.7215432164928245,-0.33087116738206845,0.47524976111305595,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11464516830631642,0.08547816541414381,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017213710853712552,0.08020732411181992,0.8307716793788308,-0.14311844550328,0.1775458672107051,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03077624123777194,0.010675330127246163,0.9817873441877563,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01693348364561809,0.10815825666771324,0.8760986734131919,-0.1992717907651262,0.23313875805636236,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10089883954807104,0.05839766336209949,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003147259557211798,0.083585588159654,0.9700852179548454,-0.16393795040841896,0.17023246952284254,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09452413517692687,-0.07385409703449518,0.9969763314031036,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022478259174704827,0.1392560762720423,0.8722900538272721,-0.3008471892163451,0.2558906708669355,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12914662530791896,0.032439291246830836,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019207719245072773,0.12245035774899461,0.8758638731610515,-0.26398249663586043,0.2255670581457149,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.20087967361859468,-0.16674381309604078,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031506046534106574,0.10078984448827569,0.755640050263306,-0.1699699818041802,0.23298207487239334,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0683464686261188,0.07223014773582702,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02099956207277963,0.07192706001808533,0.7712946946545787,-0.12278058220732326,0.16477970635288253,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05613840181637639,-0.03569486281409635,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03505996234124107,0.09611182876064042,0.7165147316008668,-0.15706484580126864,0.22718477048375077,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04467802092946637,0.03509729781875718,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010065622349446857,0.10793572553495168,0.9260011220167704,-0.20569481866525388,0.2258260633641476,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.024543087877766295,-0.01950075677064945,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012401846908170977,0.09615948783628472,0.8977975645493204,-0.17981823036907982,0.20462192418542177,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01238325492883481,0.03147309759192798,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007222253201863761,0.11028557989270453,0.947997094800027,-0.2132354797431617,0.22767998614688922,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.054313858072159354,0.018443464769500956,0.993730344541434,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05353546476408322,0.06588141714501701,0.41955481421168117,-0.18523054113876672,0.07815961161060028,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11916313375124726,0.022769950042664727,0.9275566244234728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0137328074441626,0.0666279621121254,0.8373789291712188,-0.1194545910559552,0.1469202059442804,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1673733184365984,-0.14325504453999255,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028368102856046337,0.10928177354009896,0.7960425856789298,-0.19008304978150342,0.24681925549359612,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05283677840725035,0.030499610805491566,0.973649621744121,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02913270143079673,0.1178192602534808,0.8055193294804492,-0.20638464397385425,0.2646500468354477,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.005002427851930504,-0.008469985016574687,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0376758995291136,0.10446757643127927,0.719589345964943,-0.17115181021052114,0.24650360926874834,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.002996596940553022,0.05299969669242592,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022811581241494818,0.13302827911340534,0.864405449664318,-0.28873132214915836,0.24310815966616875,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017212043534050463,-0.04571458626254984,0.9854445582989166,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018714152033315175,0.12442608681012092,0.8809343200753064,-0.23001005147603912,0.2674383555426695,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0029227054719701117,0.041942253967433354,0.9867875051416815,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02267267382626861,0.09255485097899524,0.807292722047102,-0.207687184696549,0.16234183704401178,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06859423139934807,-0.0445134726421254,0.9744449538485335,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003967704298114955,0.09869311914679757,0.9680609118499349,-0.19331702980351495,0.20125243839974488,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3495906486514083,0.32031722357695536,0.9966883940680653,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037421594581577004,0.1090767457022464,0.7327019768375761,-0.25546290241106057,0.18061971324790654,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13621518562507182,-0.16116811678858228,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11779408039242971,0.11908704120356525,0.3264379760347913,-0.355845683806137,0.12025752302127758,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06064700903853282,0.009792909261111126,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21456806231268333,0.18369798832517195,0.2472594911297008,-0.5817751087110321,0.1526389840856655,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05773208473172108,-0.01881637347239269,0.8552269457897888,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05005231858565605,0.0846423615233975,0.5564433225165428,-0.21924998840536963,0.11914535123405755,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027989630429483266,0.025107489333714376,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1540258583566199,0.2240517170662665,0.4943586895055392,-0.6018988591145079,0.2938471424012682,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011438805409754439,0.1356448130290383,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052326507122663304,0.13189102084057827,0.6929211910770616,-0.31597290113543497,0.2113198868901084,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04285411604615339,0.08004232576612536,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033451456091756836,0.08796415214543467,0.7050335283607164,-0.14238637856695763,0.2092892907504713,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.030733473389038386,0.05557015923817543,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04767123503268193,0.20780420330159158,0.8193095884853241,-0.4630659185523771,0.3677234484870132,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05463516869336927,0.08965534125326914,0.9784383200536336,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009295958236529647,0.07960286076910453,0.9074124903841819,-0.16841980958834335,0.14982789311528405,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04892789142270006,0.05883952601511789,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08514887447238015,0.08783954522337913,0.3361279218970624,-0.2607376234430804,0.09043987449832008,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0074017181897393335,-0.02905999407287475,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10210116320731931,0.18945115869195642,0.591864225893427,-0.4808086333015108,0.27660630688687216,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03860131358158987,0.10864429380485384,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06928150772682036,0.06996868997511402,0.3259354892898195,-0.20914692607121216,0.07058391061757145,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06942916832601782,0.13220066815469153,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15102105602635374,0.2279086238473602,0.5100179617823544,-0.6066039035835009,0.3045617915307935,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04304119418351973,0.054978158675799395,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.134131513702105,0.09306343938302589,0.15453429437448896,-0.32016267830593614,0.05189965090172613,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02687664451154933,0.04650798432941084,0.7729635971926234,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07574744057113604,0.08639678728022743,0.3840128650886435,-0.24845215750750238,0.09695727636523029,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012301458878632513,0.03337475287525781,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027731407209205222,0.2082230423879135,0.8944813621682286,-0.3885005237142677,0.4439633381326782,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14326162209834767,-0.012976064980654576,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18159078640804213,0.2044813620101781,0.37794324434813586,-0.22716163201449505,0.5903432048305793,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1115280525803147,-0.0928713902897424,0.9171668992289758,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05736687665194358,0.08618477298729474,0.5081186887951803,-0.22964778305553352,0.11491402975164634,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06481588735853765,-0.0397058461562266,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1355564915789983,0.11002438222611872,0.22257938555012488,-0.3554920978282031,0.08437911467020656,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0823037795895505,0.10206520998365191,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06589257215213112,0.0949666833591255,0.49036824539639545,-0.25572826725415077,0.12394312294988849,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.026593304322280974,0.05551090085149118,0.9418332435783486,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08224214255390949,0.09656490065815565,0.39767089534893907,-0.2752726285147204,0.11078834340690141,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04302667343030278,0.09910802601550302,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05062881356667986,0.16489124684218,0.7598390595058523,-0.38024171941231777,0.27898409227895804,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10235767774042483,0.049489769094450554,0.9673781001375229,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15313377251543575,0.15268162648176994,0.3197779402837819,-0.4583399950268231,0.1520724499959516,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.018200150628176818,0.07085709391734761,0.9027017389660956,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010554853003374708,0.0759049113322627,0.8898584706675571,-0.16228660875951198,0.14117690275276254,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09136441452628709,-0.05652463579225148,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.20421236389543418,0.20099447586736152,0.3135732359404044,-0.6059945962353426,0.19756986844447427,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.029231846862935583,0.01884696930694309,0.901410374901842,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09655088140229,0.11262707322830848,0.39460185386043833,-0.32168919283251124,0.12858743002793122,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.019443411361025547,0.02643175574472391,0.920957044807631,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11920654604423912,0.0720204644875238,0.10294265441628428,-0.26317340319831317,0.024760311109834912,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12756841465459245,0.12730109793138514,0.6839484127328216,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08678414350130416,0.09441161194686042,0.36154797014405593,-0.2755102666602864,0.10194197965767805,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0961613200066192,-0.0372016627065969,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0541232573875903,0.07944336937823322,0.4982305666407809,-0.21292828999184021,0.10468177521665961,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.22957974227932573,0.21312008900408586,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10070829722079476,0.08655298316496898,0.24906683040445904,-0.2737252452818373,0.07230865084024778,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04503908992353035,0.009049375937000533,0.8577407808028615,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07344329003619425,0.09195087565816455,0.42750009082741836,-0.257250471443143,0.11036389137075452,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12452533028805014,0.11272424262273861,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045765991951717815,0.07026146228635215,0.5172168149187852,-0.1862166538072507,0.09468466990381505,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03577899762987237,0.06449902185031607,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040714738117195975,0.17109731126870908,0.8126948834608618,-0.3827333899843396,0.3013039137499476,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13220958444212524,0.015053935201576612,0.9764147093858516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13419418675941566,0.1979890046929207,0.5004290182216957,-0.529968567826352,0.2615801943075208,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05086555436932115,0.009574705989155033,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.073264577684992,0.08414471138970317,0.3872782819483237,-0.24146745906200276,0.09493830369201875,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.002306494393647708,0.015444269205582109,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14981047726146324,0.1799985928404813,0.4084414154506031,-0.5096225374556735,0.21000158293274712,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10336487083551908,-0.04791515978715344,0.9252876586321025,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1545813479892628,0.08849093498449839,0.08561361129221692,-0.3314722065389276,0.022309510560402035,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.30058124404864484,0.05975049249857763,0.6528607274170573,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1707903918249055,0.09862054430875877,0.08828350058539147,-0.3679300508924426,0.026349267242631563,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008073936715530455,-0.08746920445757762,0.659371665428829,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13140693336172118,0.10823711806212584,0.22932709619266106,-0.34776984945368977,0.0849559827302474,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.4667562928099019,0.11993194367525835,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02988511476854784,0.06417110883846858,0.6430551183327203,-0.15816133355309542,0.09839110401599975,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.061066690043116156,-0.018219152804596777,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058793002671074825,0.06993826966727394,0.40377924957329814,-0.19859761168655493,0.0810116063444053,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.022113395693578265,0.041017352877646886,0.9235345118679857,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03862527792363087,0.07472832152916699,0.6070816846688993,-0.1880050641761479,0.11075450832888614,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06164209129135844,-0.00653676073650741,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08164285141149957,0.08708196481968976,0.3521186057894614,-0.2557172187333621,0.09243151591036297,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0025380447670345285,0.02021640379371971,0.9090812501778921,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05488951358781319,0.06322979114931249,0.38868971101412964,-0.18128406512325806,0.07150503794763169,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007307195941294516,-0.0199436291147765,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0380175530913316,0.08609239110430203,0.6603221368787565,-0.21011379074212916,0.13407868455946598,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0025963548047680234,0.07668680272053886,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009664873765468996,0.05961577957732178,0.8717390350522204,-0.12883511910627543,0.10950537157533743,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04666294494526643,0.0647498977204249,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03655178760844159,0.07051104209301746,0.6060356298795734,-0.1775013523887251,0.10439777717184194,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028688503027941785,-0.006043299003352473,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09120447071057988,0.09272230376699704,0.32912031118193275,-0.27655371493452374,0.09414477351336395,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.038354575161367095,-0.013545002912066251,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0572800136645405,0.05987956156204211,0.34249095698998555,-0.1769775516795094,0.06241752435042841,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022070423834635738,-0.04867666536055693,0.9045618832985359,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05236146870866212,0.0723993065863933,0.47225733490567645,-0.19708562042782943,0.09236268301050518,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03223890717744838,-0.05478385340298595,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08123882757891783,0.08145053690444141,0.32244690680918764,-0.2440561308979723,0.08157847574013662,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.014681170433910618,0.02536709107171653,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03647789384710476,0.05165855833762731,0.4827495705894068,-0.0667860928808194,0.1397418805750289,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2669156394373403,-0.12616232567765762,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01921763833656811,0.09305466315817108,0.8370615498160903,-0.20523125951688742,0.1667959828437512,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.27870129744584815,0.19453716055629555,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04651564892316869,0.20832120133786203,0.8240453353285695,-0.46294379679173064,0.3699124989453933,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14603462604152384,0.013604256786123184,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16399882785430978,0.09274576970475545,0.08193665003695465,-0.3493949798194531,0.021397324110833588,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2571943875885956,0.11489104022562313,0.6430699474171485,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09894443952062677,0.1291676985496506,0.4465737989225317,-0.35714698984213195,0.15925811080087843,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07183374496683413,0.03978177774815465,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15698511659765851,0.12454386434466296,0.2122193230100941,-0.40594475404390873,0.0919745208485917,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012118481696270552,0.0903404926107866,0.8278117867587848,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06179380519334369,0.1455864429092452,0.6727087274603611,-0.35281695783513095,0.22922934744844356,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07782385865893088,-0.03960151954606293,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16510294285176447,0.15196779111258013,0.28149307269261176,-0.46888222879229036,0.13867634308876142,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1308791342453381,0.17373252507759063,0.8768618853741261,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1358714050581814,0.13379921764605496,0.31382014079118453,-0.4033322301339951,0.1315894200176323,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05897852683020398,-0.03594464988645077,0.901410374901842,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09975870330889046,0.09284440347431765,0.2867751197002408,-0.2853520213700063,0.08583461475222538,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026071157601300975,0.03327789005830006,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010994580148017468,0.06904846211672981,0.8740053159799082,-0.1270313289182837,0.14902048921431862,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019838126335815023,0.003887999614757713,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07258852816096054,0.1293043572534732,0.5765639487928725,-0.3310642553389618,0.18588719901704073,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10501060074982226,-0.04080608543323524,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08810403277311858,0.11025859669399886,0.4273020298597635,-0.30850782707249297,0.13229976152625578,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07433871822934321,-0.01862668644756953,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1929927281334187,0.13008905474217355,0.14299619525042595,-0.4530370432408196,0.0670515869739822,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01880574970174036,0.02490453964802787,0.7607934302264618,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006867331021730341,0.11564241575913982,0.9528371033737617,-0.23803322628518275,0.22429856424172206,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01636935354940123,0.0029608199791310943,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08083345473200852,0.08981931421785226,0.37162583306475094,-0.26037970553296635,0.09871279606894932,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011702076525120517,0.021881197866743776,0.915561182973695,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03959498546774241,0.14717988783241145,0.7888041231969318,-0.33380338912490043,0.2546134181894156,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03558443282611294,-0.0029474172573889464,0.9726336318937702,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04532247346546118,0.08324825482919117,0.588101498610778,-0.21173336371175072,0.12108841678082838,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.16424990347908125,0.12847191481521658,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056283787344949536,0.08292763233675084,0.49984750671558353,-0.2220537623611306,0.10948618767123153,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0197556962723105,0.007652844695866537,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01691992188836813,0.06368487334554412,0.7913656212655777,-0.14422416977198904,0.11038432599525277,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023741919778395824,0.032663493520005894,0.9732342286065081,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07472365079231574,0.052666150014204674,0.1609599285066762,-0.18000178458251795,0.030554482997886462,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08562460252098772,0.06804291343161738,0.7815068115919459,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0717052707332874,0.0712966915668157,0.31845426273752303,-0.2142253264340659,0.07081478496749107,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09010325917044583,0.05503711588962948,0.9027017389660956,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06207406264083213,0.06903504545904804,0.3720425040739582,-0.20007315219057364,0.0759250269089094,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0035163007116496866,-0.0007159000106520541,0.91574265170323,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19707754954125511,0.1924153318974239,0.30970639813148465,-0.5817103174447296,0.1875552183622194,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06443684543191126,0.06657268457654156,0.897405574514287,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022963822053055354,0.07768943123818152,0.7685348070632518,-0.1323351381665927,0.17826278227270342,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0012362156560315847,0.01879045693326532,0.9691554932400821,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13639567296815616,0.14897948799820626,0.363459003552576,-0.43420142609878654,0.16141008016247424,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.030881026528582767,0.03358079576520137,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006366639227022556,0.0748467634897646,0.9324859334608139,-0.15598318758519578,0.14324990913115068,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.015036510295222377,0.008502677670965563,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06957373843351829,0.06475092396166698,0.28677038630996055,-0.19900899113448467,0.05986151426744811,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.044056639784671094,0.05250624852334038,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00830347008300298,0.07894097858588678,0.9165679407379784,-0.16610423780293251,0.14949729763692657,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.058465728670314764,0.023437575548623135,0.989733344444655,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05872096309662252,0.07148143194245721,0.41451753989863993,-0.2016103095463544,0.08416838335310937,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00967854716676297,-0.0074537725047307615,0.9266313996019341,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05439644171604384,0.08048473194028216,0.501642591454112,-0.2152831284207345,0.10649024498864683,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020923968602057783,0.10781639380645992,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03342769689313529,0.047181191924954846,0.48129256709946877,-0.12774155569080528,0.0608861619045347,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09149718288923324,-0.06980491028693536,0.9396519533333579,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006780993226990182,0.07911982430838496,0.931976812234715,-0.16493926845213686,0.15137728199815648,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.002001434507253238,0.06168091260792099,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039351982509248436,0.06424141558271644,0.5424049509210516,-0.16776874247300283,0.08906477745450597,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04336416534138956,-0.03902969818041596,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021312383820479588,0.08322470034271397,0.7987349519211195,-0.18767618931920288,0.1450514216782437,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026435521881119976,0.08856914655554565,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014236542508926149,0.10598599219360282,0.8935808770827507,-0.1976264370906079,0.22609952210846018,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11158459392207978,0.12085938707776667,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06944048554148771,0.15635352567358538,0.658498634695531,-0.381986729950732,0.24310575886775657,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08869116082369355,-0.06958960028929818,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10204440903978386,0.11779984657720013,0.38969167536397886,-0.3375229470585089,0.13343412897894114,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05017502651803907,0.10136820954598265,0.9196137660184385,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08649954929763502,0.11275356913886336,0.4459005223372493,-0.31189072245007665,0.13889162385480663,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04231735450566694,0.09008848874229473,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00023324135738833282,0.11812382840605812,0.9984308780077663,-0.23635940982403683,0.23589292710926016,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03993279701575794,-0.022639004121488383,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10149759175121495,0.13174467249292235,0.443981731056462,-0.3648514395854575,0.16185625608302764,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07576073060081973,0.011091640257739394,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03093054569702675,0.09403481512809479,0.7433197260388857,-0.2189034627475877,0.15704237135353422,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0043591877130328095,0.048767907641745434,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15067975363787045,0.09412686900328757,0.11450138858861479,-0.33883668376297427,0.03747717648723339,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008738436336420767,0.062308186190204,0.7128721746011171,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13568545102584106,0.07288579611893008,0.06739872422130876,-0.28138208146388427,0.010011179412202142,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10098526105973869,0.014366348317108299,0.5990506592577463,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16486811153390124,0.1252741821836197,0.1929997154380639,-0.4152876335386073,0.08555141047080483,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02440893370759195,0.08173202777056034,0.8140390093255331,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028742281730394947,0.0825488163340168,0.7288805241527444,-0.13627045088612436,0.19375501434691425,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21210986562953707,0.17118017159605636,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024246033729939706,0.07699040942796326,0.7538777380439433,-0.17814766926117637,0.12965560180129693,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04046435822819438,0.06480276197581393,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10652043522989907,0.10556930369242286,0.31689179817390845,-0.31755046638409906,0.10450959592430092,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04207958295207789,0.06796404422659548,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12821835985861912,0.11507499379485546,0.26948744075579484,-0.358249994777328,0.10181327506008972,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028263816654491108,0.03938620482741181,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01449971291810322,0.07325442586071565,0.8437424287724885,-0.1319337978741007,0.16093322371030716,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07733280309842863,0.09066175234141,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06359790335486995,0.05491206610133953,0.2512336821858476,-0.1733655594329018,0.0461697527231619,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07295311527351002,0.02416188110874941,0.8585176148211594,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02882116697455,0.06562776598075844,0.6620715404256959,-0.10236686794751823,0.16000920189661824,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.034994100504257566,0.00452995824092108,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009466353656663939,0.051631856109763126,0.8551269512199242,-0.09374425607831838,0.11267696339164626,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007973763073357877,0.013497694607407596,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07007655667122607,0.12019526460161387,0.5619927898013442,-0.17019035374969033,0.3103434670921425,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1399073821966028,0.004942160964827659,0.9512976205783472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0038743365251771395,0.06408336802225235,0.9519855234900739,-0.13197516391722722,0.12422649086687294,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010674611876276498,0.05138027702751783,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0016059370617430672,0.10463181229146862,0.9878034669510162,-0.2107619496079718,0.20755007548448567,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05075239665027475,0.04271693102143178,0.9990191441902606,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05153539062791111,0.06778449677423747,0.44996713264402455,-0.08396388772023052,0.18703466897605275,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.025468159501048544,0.027028609513426893,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056434684032070026,0.1191214788366868,0.6373369750339041,-0.1816857592293613,0.29455512729350136,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09397753311978665,0.04588941351625586,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0028170335420236877,0.06457684736500718,0.9653451370469728,-0.12627024500043765,0.13190431208448505,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07220682556844972,-0.04376262103651183,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04622883068179788,0.05583052645176341,0.4108347995604893,-0.15783246283985156,0.0653748014762558,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07094435303684242,-0.06710711038603161,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006615424342095407,0.05824749067492682,0.9099421460697688,-0.10981965045575064,0.12305049913994144,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03801801627199407,0.04860025246290805,0.9890962952045544,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07585993865602793,0.07206603480019974,0.29658912539225374,-0.21991788956716346,0.06819801225510759,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006876093083611937,0.027385913480164503,0.8839993607754738,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006683123661101191,0.16088703321854572,0.9669995008513685,-0.3282917205249771,0.31492547320277475,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04288175749432713,0.15758657686312336,0.9962315319978402,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2619488626015367,0.11943124147676644,0.03204484848673418,-0.5006885125575283,-0.023209212645545124,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.058303010579078246,-0.00950952820887294,0.4282445913712306,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029136576042823017,0.05383195672240703,0.5902745086997161,-0.13674512423708818,0.07847197215144215,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02484150738954753,-0.012997358501426295,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09035774581033848,0.11920815058007725,0.4513327498976276,-0.3286514434181389,0.14793595179746197,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.033547458750776256,0.050821720873696415,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0708900475774352,0.08128320993874118,0.3864989323171626,-0.23337286905802324,0.09159277390315285,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04182506428097234,0.06273813419940098,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0971533460433389,0.09108686508017907,0.29028784960054504,-0.2792333949144791,0.08492670282780133,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00060232358697082,0.06407870718128474,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0827702802609627,0.08461890097253487,0.3317997601537298,-0.25192105310772794,0.08638049258580258,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04699273341896308,-0.0032221351321852034,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10850551839521652,0.0989280411455415,0.2769651890650821,-0.3062598548810601,0.08924881809062707,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012128664504110048,-0.011186386467147591,0.8725380346331878,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02890236157705045,0.08434992898989763,0.7330220251487451,-0.19751546709164386,0.13971074393754296,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.017095637219783858,0.05313257893873966,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.23943291061598718,0.181577979967122,0.1921454266206974,-0.6024021206907214,0.12353629945874708,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04584439264039542,0.011030338399288594,0.813283143145888,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10502812894837404,0.10261994920975619,0.3100639547530179,-0.31016248449808864,0.10010622660134055,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1485217804704754,0.11487059604281337,0.897405574514287,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18756052696841116,0.16872550816666415,0.27058889948045856,-0.5248380119905555,0.14971695805373317,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09936370078528724,-0.04343720722599001,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01181301242013329,0.1042974473867727,0.910188225197655,-0.2203006390455793,0.1966746142053127,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.066851608689787,0.10758758447328416,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13306128176792692,0.12515347781761654,0.2918216785337115,-0.38323951918301113,0.1171169556471573,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0613415055575294,0.08421690028568812,0.8799526010712531,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07418747090634732,0.09412652849558373,0.4336019350852496,-0.26234372036624987,0.11396877855355524,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019031679594476263,0.034412772533385864,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021612336875358417,0.08506776214960539,0.8002897048518167,-0.1916603704301897,0.1484356966794729,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0949894842176305,-0.03306537324557634,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011307996772046029,0.043710224651019064,0.7967208141238107,-0.09868349085256338,0.07606749730847133,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0769634974160359,-0.04382544930680083,0.9738068609884574,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060345532573775354,0.06383859492028932,0.34818393370615697,-0.18795706550686542,0.06726600035931472,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0287597854083996,0.0231640930341942,0.9086350165348037,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12676826127095905,0.16931049697184425,0.456849643569317,-0.46521512225244177,0.2116785997105237,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03736138975033368,0.17226789721262584,0.9353936944091839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04018781147812887,0.07448900999628583,0.5914651193511513,-0.10871359783646112,0.18908922079271884,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11294545702765683,-0.07950583526837716,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029203517551344746,0.049664549524083015,0.5586578314100665,-0.12848153745628033,0.07007450235359083,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04570871334638391,0.01733575696993306,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014940545678600536,0.11924180101923167,0.9006944484842638,-0.2533015095558063,0.22342041819860525,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05946473955766883,0.11771455952033494,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04782554671722569,0.06799754457474809,0.48447541608689604,-0.18375070155035467,0.08809960811590328,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028566924023608848,-0.004861228523442583,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06763318333297472,0.06328436270062772,0.2893398373239133,-0.19413682184513906,0.058870455179189624,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11285111583251055,0.08779403111333807,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03119670895665311,0.0518235502395262,0.5493830219551079,-0.13479050979701432,0.07239709188370809,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004448728649601252,0.005339123769048107,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02876457301998437,0.06085372517938033,0.6380985200498067,-0.15040943635894258,0.09288029031897382,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03320574551514781,0.03893837787623535,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1889070321995047,0.13447064647109394,0.16506538183513986,-0.4577100243722865,0.07989595997327711,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020031140778084502,0.056494528080799696,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08257883567246918,0.12214090978376495,0.5014947658816791,-0.32673503539475884,0.16157736404982048,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02238082134361853,0.018468184917994453,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04678049259150493,0.044845797432586425,0.3009333745829616,-0.1364259643178938,0.042864979134883956,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023733625776312627,-0.011654871115834978,0.8886938718153086,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21168662968391663,0.16660515131684228,0.20862212796051804,-0.5447255817573204,0.1213523223894872,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06016204516471764,0.008491254040802698,0.82185729615414,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04078385665313002,0.0858049700055384,0.6362371851485461,-0.21230554771410468,0.13073783440784462,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.022957138136197198,0.09378424207169546,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03526272833948941,0.11854120594056149,0.7671003971313283,-0.27222322260945975,0.20169776593048094,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.050533730830838244,0.021620832304847806,0.9686101294099047,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08603713831700188,0.11328060024419168,0.4504289619501136,-0.31248183163758547,0.14040755500358168,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11606840161320227,0.11620191191351241,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12055402470223407,0.12879539797011713,0.35289871166074294,-0.37801235676947686,0.1369043073650087,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2525899369873748,-0.09311384574226417,0.9092831415853414,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15364916059234507,0.17113010743867124,0.37273902755690913,-0.4957333710691108,0.18843504988442067,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09213623084089861,-0.11407002154482372,0.91574265170323,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1307632710516499,0.12174199183915696,0.2869397142257072,-0.37412204516503467,0.11259550306173488,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06072198976033141,0.08264255234789135,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1245726219281003,0.13585156369197735,0.3627084477432231,-0.3961360282928089,0.1469907844366083,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.010441727749500782,0.05828215754946242,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011510884590262869,0.09970711367701812,0.9084639474232209,-0.1878007956957056,0.21082256487623133,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10843954731570647,0.03330352718003589,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18755830724829525,0.2514337558185179,0.45851352535551826,-0.31505060905364757,0.6901672235502381,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7406494660728281,0.5593809142026869,0.9366135780422296,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08245080130863104,0.07351869749059048,0.2664024161740249,-0.22941258356171473,0.06451098094445266,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10352479050793097,0.12138120786792465,0.8699728633396779,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06596646855325612,0.08757448117804767,0.45414384174617217,-0.24102536204714914,0.10909242494063688,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10453007281338828,0.09437800485525498,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013041384997834412,0.10592033173152994,0.9024067972907215,-0.22477311120388954,0.1986903412082207,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1154302898003767,-0.03467831139044332,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06837145530945568,0.06199981503377779,0.27438982206271234,-0.19230731962331535,0.055564409004403986,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.035735022959432206,0.07962980723663794,0.8709804306040525,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037455094490614946,0.1068732533408507,0.727179363103563,-0.25109168385166786,0.176181494870438,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.15784605102897478,-0.05491212105900852,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028861686738844698,0.114705508804849,0.8021704099137265,-0.2581547316865593,0.20043135820886987,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11755622320211559,-0.040206951429319064,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09427301583000937,0.07057826870173611,0.18652258137586414,-0.23535696468630823,0.046810933026289483,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023632996627549776,0.04681239592550973,0.8085168201280608,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013876817277451742,0.059682749200887175,0.8169079855845334,-0.13318093298827183,0.10542729843336836,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05556771461916941,-0.06125219968191342,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11546964181831659,0.08716448786144218,0.19012197420894142,-0.2897089703501412,0.05876968671350799,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0431604718853342,0.04844338313353284,0.8114284597256536,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003793809183805815,0.11809059554265199,0.974474561250541,-0.239853546103076,0.23226592773546437,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0674342572179907,-0.016681900834958286,0.998018743752871,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13809478409729878,0.19273319404924885,0.4763684064331263,-0.5233629493886143,0.24717338119401674,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0040136250469517895,0.10367019257698316,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07242698815954289,0.11871315371072153,0.5440248469198228,-0.30973120112448055,0.1648772248053948,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06842097226576468,0.014434285149328901,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11010498841792907,0.1281874688068466,0.3936839174056668,-0.36634808740342006,0.14613811056756196,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06117086510090709,-0.06351302185515893,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1514894286052168,0.13667753599689564,0.27198274841020115,-0.4247039300813155,0.12172507287088191,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.013244245223101823,0.10980824609450095,0.870021716674458,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05849307059221724,0.05988704476267512,0.33250188913160794,-0.1782055673121078,0.061219426127673296,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06591760222892513,0.054058946090447556,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044879890684995455,0.19443970330022736,0.8182173434452141,-0.43355931936257097,0.3437995379925801,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2118002089016691,-0.06946062615310906,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05995345756498205,0.21313292055527336,0.779419996129309,-0.4860000950971114,0.3660931799671473,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10355703670646739,0.007950738369063728,0.9705004312583027,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06948326685640341,0.05477761270381014,0.20937552973315038,-0.17898215442240561,0.04001562070959881,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.024883780102258023,-0.04134068600038999,0.8231911614768439,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07287945654783169,0.06361583876023393,0.25635597621000417,-0.2000457062617273,0.054286793166063926,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1070997280531858,-0.010694751053376653,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14187158776883083,0.06874876503557437,0.043245860734290174,0.004444764631497428,0.27929841090616425,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10319793101546246,0.016328867707932765,0.4971708399879019,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09856262761324755,0.07499967957788378,0.19362910530907781,-0.2484848508760672,0.0513595956495721,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.13382113263723713,-0.030423671056532948,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11931259827791901,0.0811075879889778,0.14633745529084122,-0.042819159927326184,0.28144435648316424,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2100794843127106,-0.0690563960677896,0.7662201971017615,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04761375240061643,0.05865839642376836,0.4200621142620091,-0.16487021608658198,0.06964271128534913,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07400379973802607,0.016304116468372563,0.9279200175745067,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06302832111901126,0.05241144732872813,0.23371617356924454,-0.041740669257611426,0.16779731149563393,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05838505683579801,-0.00982105611950013,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04405841018700396,0.05246429579120651,0.40425901453155255,-0.14893304313483996,0.060816222760832025,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03852382899295213,-0.01314873508834793,0.923721375173133,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037038589809141674,0.061491407325191795,0.5491460924354223,-0.08588098197621438,0.15995816159449772,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02601638722204349,-0.003927374810024698,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09014272775391852,0.06377526361115954,0.16252666068455568,-0.21762766320392174,0.037342207696084706,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.005155204865407607,-0.03349801095555026,0.7815068115919459,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059969410686750074,0.07173526121542195,0.40637517532136747,-0.08342733324982762,0.20336615462332777,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.050920045410471904,0.04640319250259903,0.9239663408808872,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03487483198171605,0.05514301756312454,0.5294228092872875,-0.14510415345367336,0.07535448949024126,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11762923954332728,0.022043361503767577,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03442611652561216,0.0426921892567021,0.4231062826033596,-0.050914353798333756,0.11976658684955807,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16858834985983634,-0.12708501799151226,0.9288749656602147,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003017015958909421,0.05549334994676719,0.956817452075458,-0.10791260996944395,0.11394664188726279,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.054921152433521726,0.005933009275818018,0.995747388821315,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009085431482253287,0.07019972645373893,0.8974422206936513,-0.149412685166812,0.1312418222023054,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0021465628168596596,-0.03760656156139052,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043059513469674696,0.06133017985369051,0.4852484184956377,-0.1656567961317364,0.07953776919238699,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008908276271013205,0.0022167533464695585,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06748599434527074,0.09554325183686416,0.48262290412570097,-0.12350224472136774,0.2584742334119092,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011362261029651299,0.0022954671486750677,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005481109682688592,0.04895789363983656,0.9112202989052856,-0.09238432523729428,0.10334654460267148,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00128328011758316,0.03302549366346439,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00018722279436271657,0.06351456090814019,0.9976575316386577,-0.12715102096661665,0.1267765753778912,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0697974096258331,-0.028468230584404536,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13272034433322547,0.06912736723951526,0.05946923850150815,-0.2709039824925228,0.00546329382607183,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3612254430561637,0.19909037535032578,0.5680556875544357,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003152003879153542,0.0769334927671726,0.9967441903287355,-0.15347266035955612,0.15410306113538683,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14101852713493251,-0.11729352355056011,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01714045221643202,0.23386344441449305,0.9418092516149403,-0.4846268164763224,0.45034591204345836,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05363628923289958,0.0851528709343523,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21194219724699337,0.22070872000156477,0.3406443465515885,-0.6531326420910165,0.22924824759702978,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05704613021531319,-0.01940187632070333,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0069387191619767015,0.12927163374984432,0.9573662862019707,-0.25147159466433294,0.2653490329882863,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.031160206847485817,0.07440794558598496,0.9957512552242196,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21903218784769543,0.23261721370978342,0.35005234098747195,-0.6840273724252188,0.24596299672982794,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.014896116249610574,0.11830682230665035,0.9086977961712401,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021686281520677357,0.17777562965872393,0.9033039981332165,-0.37705470163114085,0.3336821385897861,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03917065786455341,0.13241815752563948,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08364111996882231,0.10791117171167515,0.44123134102317985,-0.13207023865251438,0.299352478590159,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03430294238380568,0.11637840749977924,0.9321782450874811,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023556690530175707,0.24503776138878686,0.923723470733733,-0.4662668150836306,0.513380196143982,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05906408970659577,0.17254627960396018,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02731745507349313,0.12190255219406458,0.8234221059344892,-0.270997184763103,0.21636227461611676,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.049110325507044486,0.05859615710459944,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0523577775092386,0.13244441324713255,0.6939644761782837,-0.31711038718045487,0.2123948321619777,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.010712031886115593,0.006994177846288597,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17839507693439505,0.22304587998377443,0.42687278422739405,-0.6242574380136054,0.2674672841448154,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.034346900464611224,0.08618957525500313,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03901739854940963,0.11812180543696457,0.7422755898838944,-0.2751395231584603,0.19710472605964102,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06789695653796182,0.16344795193470954,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18539869082940622,0.2274166001007756,0.4180567534081695,-0.6399979969314268,0.2692006152726144,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04135848511646199,0.05405297862955866,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0942594054913634,0.15424838349814607,0.5433750446545538,-0.40259753065259885,0.21407871966987202,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02407567236009415,0.08460611254073626,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052540791406277404,0.14945833780200812,0.726374159142958,-0.35130375165564476,0.24622216884308992,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013693216356243662,0.0594894364528919,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3655086514613712,0.15510943202134342,0.021624702582263133,0.05544931482748061,0.6755679880952618,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.15932928647650005,0.20910655185634286,0.34058906567064434,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3351862084325087,0.16893058368064207,0.05166849527137305,-0.0025012167009185182,0.6728736335659359,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11959760931471784,0.0093085343280904,0.5339911008653665,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05774168128097462,0.1196285550090472,0.6310266090204282,-0.29687575536792066,0.18139239280597144,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06474134798694998,-0.03559321824913379,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0768380959274682,0.1562480812222409,0.6246186894116631,-0.38917355988184565,0.23549736802690924,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07785100664900821,0.16034132593708805,0.9593389007132584,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1234623306268464,0.14464772186516842,0.39664669760606264,-0.41260900663908434,0.1656843453853915,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028616946266658245,0.03660598843593062,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13048201799082312,0.1379848106367287,0.34801026801184887,-0.40630972423688816,0.14534568825524194,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04561206304951979,0.07878254317809556,0.9086350165348037,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018986932787271957,0.2642770149732095,0.942956669809797,-0.5472691583253214,0.5092952927507776,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10433416122272804,0.10397235694552501,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12173337773276102,0.20007077371729629,0.5451107708832876,-0.5216691557844666,0.2782024003189445,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.016618554556487284,0.10068395464979399,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02246005919980226,0.10422015159753664,0.8300802833708245,-0.2307931737441788,0.18587305534457427,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0921312132391315,-0.040201735748742626,0.9817239773275311,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3292457447037684,0.1937157531882934,0.09421230659856103,-0.7164780177278348,0.05798652832029805,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.021953348900246566,-0.060334942603887276,0.6707240267079618,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16551816875435668,0.14448669017427054,0.25637985690589987,-0.45434294700315003,0.12330660949443664,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.016870490052412757,0.004217149200797762,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010885839911559047,0.10719195789956716,0.9194379122896178,-0.20338783078471676,0.22515951060783487,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11882618631408777,0.23390282034090087,0.9903757974905041,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11533711701884221,0.1230420794026588,0.3522006505478793,-0.3612947291413165,0.13062049510363205,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09388679569396022,-0.053158927861031956,0.9090812501778921,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0627522602664637,0.0989789921486265,0.528415835835406,-0.1351039258233111,0.2606084463562385,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.22099349408494512,0.31458038632048185,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08095120378530996,0.15872381556371845,0.6118532485970958,-0.3982355901720424,0.2363331826014225,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04581592937009881,0.02934451035724193,0.9549530254352627,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11030063787587074,0.10552386556183843,0.29995773627028494,-0.32123983950124524,0.10063856374950372,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12412119122124537,0.11529452170469415,0.8872737746993358,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05133917993375295,0.1134184193757434,0.6523786689502276,-0.27805936977281065,0.17538100990530478,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.033811069937780554,0.06054590790283358,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029502539830200132,0.24098379668471273,0.9029580874375833,-0.5112222854695037,0.45221720580910335,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13350097273083197,0.06026157625253918,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14805000147963412,0.2148399302878536,0.49332014781633204,-0.5775089028464901,0.28140889988722184,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05071662598066658,0.019845831719264444,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014360183741627846,0.15310738094951365,0.9255771625057492,-0.29169710982402886,0.32041747730728454,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008093269176045685,0.0895930742706835,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1746344519154725,0.2238487771066563,0.43827392403207543,-0.6221017814744318,0.27283287764348685,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10078527242995158,-0.06829631812540386,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10839288144158934,0.11840555393107742,0.3635088562906359,-0.3450822112083727,0.12829644832519402,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2935820074423415,0.0969750287854654,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12851302008535037,0.1496756966141458,0.3938631962542276,-0.4277104744091571,0.17068443423845636,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.003245219461514096,-0.04766748219319961,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016231192921195986,0.11802112406990668,0.8910592313295967,-0.25215205834520193,0.21968967250280996,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.4541626667514421,0.20420931176153942,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0018661223797050712,0.09989126301831831,0.9851551470951936,-0.1978136671944029,0.20154591195381305,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06316417609357729,0.015939684458732818,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040110150184146424,0.09328352011877891,0.6687002265496682,-0.2265812499101956,0.14636094954190274,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020271370640037045,0.0672708499676635,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019158089147160016,0.12204690543594089,0.8757760615391371,-0.22481019856135204,0.2631263768556721,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0665423342915154,0.0642672699763777,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06745106140494897,0.10837328985949116,0.5359641711925145,-0.28408618104127403,0.14918405823137612,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.002519251225362705,0.024538012297474286,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003829759957464809,0.1288895549718991,0.9763909861272442,-0.2538167892744694,0.261476309189399,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01211296802276315,0.036159503644444486,0.9980529036429133,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07295457761408881,0.11158027179309064,0.5156388592517627,-0.2960003627913199,0.15009120756314231,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0002808785873465072,0.05744118684180297,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05531997946737042,0.10325203694001957,0.5940301658153113,-0.15107790145140695,0.2617178603861478,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04227934147852353,0.12184725056971986,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11982102555395265,0.10440432049419963,0.255516732329314,-0.08888023736917665,0.3285222884770819,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0379881378987192,0.11194128722504997,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12636820524121062,0.13873932742608472,0.36591165862176345,-0.4037041690583218,0.15096775857590056,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0376102113326002,-0.017664327173162207,0.914684777397777,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035430435523633376,0.077846312072742,0.6506032842766754,-0.1201821250158695,0.19104299606313624,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027931838554970726,0.017511345922345677,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028045578719412562,0.08012887710191197,0.7275205070733963,-0.13212976429917755,0.1882209217380027,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02660115094779789,-0.00340777951733685,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049580157320048245,0.15561017776963734,0.7510873070694561,-0.26148015580195744,0.3606404704420539,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022337232691528888,0.12678070291578486,0.9646550643928868,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08207164936823759,0.06289139291444254,0.19672433519213697,-0.043646453734287896,0.2077897524707631,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2658350435767057,-0.11119493242546312,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06519460487735627,0.10787658485116411,0.5478199632329933,-0.15044761559495523,0.2808368253496678,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2704655081257643,0.27818096288340843,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07182718240143028,0.2941184952544636,0.807873214830857,-0.5161073122449594,0.65976167704782,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.15201754778916418,0.11852367867286459,0.974516576191754,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1865522305025814,0.14146120219461616,0.19210258402794742,-0.4693291444549188,0.09622468344975599,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.25522011297878083,0.1105165209927687,0.813283143145888,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055616555199419944,0.17663501618522312,0.753919813307824,-0.2974718110655709,0.4087049214644108,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06112296950424082,0.16404284494805715,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3007828684215641,0.15072372406189474,0.050376845096270384,-0.6020752997624902,0.0005095629193619944,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004251069296402361,0.014849856193806063,0.5275612089369318,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036042302551548,0.18329624708700393,0.844756985600134,-0.33036167455448523,0.40244627965758123,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08238969545748752,0.023746157218901713,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.25371117747000665,0.19871520599068995,0.20644912949355126,-0.6509372142468165,0.1435148593068032,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1337445761754648,0.1473448116964951,0.8202168117716766,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049322741880593476,0.16936279724391762,0.7718510506925969,-0.387874149616284,0.28922866585509704,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0638963911884823,0.028660070673295523,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13787233128499915,0.13235031410018927,0.3015854065304564,-0.40243683944169867,0.12669217687170037,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02447907242791918,0.025724260474962367,0.8896367821404172,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11221589669682924,0.08315003727688194,0.18206478971191004,-0.05399865945992144,0.2784304528535799,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.013575860800776086,0.07709761379802137,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11322924070357338,0.14051421269470996,0.4234262567253324,-0.39411314961866856,0.1676546682115218,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10204438473086219,-0.06415301780123081,0.9288749656602147,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09882099604889256,0.15984241050434456,0.5386816546783821,-0.41834142186103423,0.22069942976324913,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07355874016363641,-0.017000012492837953,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16843845321297723,0.20215583401497111,0.4079241660716133,-0.5725422074110319,0.23566530098507743,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.014540376841125689,0.0781618465367844,0.9246436408556443,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12347422971920217,0.17210803637433192,0.47580763481149946,-0.220564832845632,0.4675132922840364,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.024780222515140456,0.10943945606685619,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12797169570323927,0.1378868420951943,0.3569589137959648,-0.4036035656252117,0.1476601742187332,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.012847348727516117,0.00994470126584209,0.911668967477982,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054507782893745256,0.21817096351887977,0.803537220431298,-0.3816097590242237,0.4906253248117142,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04350394370886264,0.10019801862590212,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-7.318198786486312e-05,0.11485293153913395,0.99949364973972,-0.2296609207823782,0.2295145568066485,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.16028014247363323,0.16974740134890948,0.999766777543677,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03455352027828636,0.13985775960052577,0.8056766151731718,-0.3141251981558389,0.24501815759926618,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02225131016811618,0.04358104241833126,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00799775694131036,0.10163237802617664,0.9375302447421289,-0.2111579858240065,0.19516247194138578,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.022406299060474345,0.050742381026969915,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035284390012290764,0.10477262206166442,0.7374267763031642,-0.1741530972538794,0.2447218772784609,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07805298333413875,0.1569003296933006,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06431283688323905,0.11709893319715978,0.5848286388273726,-0.2983902690193558,0.16976459525287768,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08849398056668722,0.06765708619932109,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06793195889635578,0.11619840515540449,0.5609244509105882,-0.16434534333400228,0.30020926112671387,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004165736755426627,0.0921585169432186,0.9509691818071948,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21222777070302565,0.1951043258250553,0.28090919753480476,-0.602235760877311,0.17778021947125974,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06170729548845441,0.05947408126805853,0.8765161989116668,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054088598867518066,0.09701800596427548,0.5791857810643487,-0.13984763169444306,0.2480248294294792,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004139256116781576,0.05821288507227458,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1975799826320653,0.15207155055667007,0.19866661293425344,-0.5015666807459502,0.1064067154818196,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027655019033122626,0.007115868779344467,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0035041854518935264,0.12323192671357126,0.9774059895417551,-0.24283292603768017,0.2498412969414672,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.015951681981122828,0.024375609832188692,0.9982821339400993,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05421075171039151,0.088715203529586,0.5433904984763007,-0.231549916693853,0.12312841327306996,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.041150929119032814,0.0896458403918613,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014390915208123368,0.12015184452776255,0.9050504502742435,-0.25457103013814353,0.2257891997218968,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05696546840396939,0.021515061142997286,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002663093701578701,0.13883698447430481,0.9847579576198561,-0.2801942711765194,0.274868083773362,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.005156584764090644,0.044287704873572906,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0863956058378185,0.1366137733969547,0.5294458950370223,-0.35948264769278326,0.1866914360171463,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023155249071925805,0.09797325711495039,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010477126905668252,0.08226064902982214,0.8990637159900621,-0.17491382128896216,0.15395956747762563,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09124282893342074,-0.06856957402738821,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021165023543467745,0.13315609349346988,0.8742257190146105,-0.2450102146694121,0.2873402617563476,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0004962247168664368,0.10408825076231458,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007464314993176378,0.09306397951345448,0.9363315378680832,-0.19349655930234974,0.178567929315997,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04462661171637663,-0.022760958973378983,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018489710865970108,0.13321622243758963,0.89006219247358,-0.2847851451254947,0.24780572339355444,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026702819458645322,0.11483111068868794,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07777363259837736,0.10996706152801672,0.4820643199380744,-0.2975946564047398,0.1420473912079851,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11424936732107968,0.09020411024110525,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04031391486641336,0.27769126210847833,0.8850433891555238,-0.5954108383503118,0.5147830086174852,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09295802837767198,-0.013713504023882096,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05115535201972369,0.1719960193249417,0.767138845943466,-0.39497049569340476,0.29265979165395734,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04500737398739434,0.17465220702543707,0.9686101294099047,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19148129672319145,0.16608452480372987,0.2533710337460124,-0.5234795312258711,0.14051693777948823,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.046635220543792176,0.04696474992449234,0.8628310878918259,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12021412687002937,0.11162250294025854,0.28566624450113065,-0.102916077167522,0.34334433090758076,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.046609332479862986,0.062273487119447066,0.8772219144487331,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032223893366028454,0.1963515559067232,0.8701758308234031,-0.4247250609487552,0.3602772742166983,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0800810214078301,0.08116966227497799,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0630462859119825,0.1525021575459973,0.68073093253369,-0.36789375513256806,0.24180118330860303,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.002350473247773092,0.03488701023653256,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11061838060794947,0.15270982684669807,0.4715634781423532,-0.4158809748455981,0.19464421362969914,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.006460668697161343,0.10081090135992563,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1055276149300687,0.13042624463715935,0.4215529218385633,-0.36624596303337764,0.15519073317324028,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09574442033550984,0.060980822604174624,0.9282753503874777,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1827097301736002,0.177379309145078,0.30698773025548554,-0.5372859168656694,0.171866456518469,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.025180567612703604,0.08378271294079194,0.8959335604367346,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04465632448315292,0.08490183420496605,0.6007813111598697,-0.12506002383646447,0.21437267280277028,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.20881013785223645,0.20325091167242762,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03352879815772229,0.12784318563233077,0.7939865593076108,-0.22202608856811779,0.2890836848835624,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.037055709807167325,0.11125595346186778,0.9732342286065081,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1355239515310223,0.1722880436550881,0.4345050927256643,-0.47992284352294673,0.2088749404609021,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.042138220270967974,0.07242556119103996,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1338116075081718,0.17468356529086695,0.446569350949937,-0.4829990790184554,0.21537586400211176,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.026956186701651157,0.05756376788664334,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05344011744305508,0.08754364622712414,0.5438018213274571,-0.22843737274832282,0.12155713786221267,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0806770787844374,0.052527378820699334,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01765130293032599,0.11388547672741639,0.8773313444879529,-0.2100025212515471,0.24530512711219907,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06655126911178019,0.09250615744890119,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07167487214919557,0.10117501589476526,0.48133671399743194,-0.13057110285983953,0.2739208471582307,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03893056950054126,0.06045969174461796,0.9396519533333579,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030965041728657244,0.08952321168257575,0.7305975392838049,-0.209919391995476,0.1479893085381615,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006278587354865931,-0.002889157622041018,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21204003353134243,0.10837911435484257,0.05491827281295505,-0.004606729105291252,0.4286867961679761,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14492647170303258,0.09514496157555763,0.5490443949486614,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06641153349189974,0.09258377798756558,0.475874981772351,-0.25148386862838523,0.11866080164458576,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.013597307523571469,0.023864523160767467,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1571044155904382,0.1005421865749604,0.1232435739763312,-0.043876551633163396,0.3580853828140398,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.056876914852252554,0.13612991861990223,0.7246722149808276,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043748916372181895,0.09384024771931035,0.6427016959908478,-0.14383506597007595,0.23133289871443974,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02496580683992374,0.033469401981625194,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17613581641271014,0.11368288140474547,0.1263848104977076,-0.05111302548965957,0.40338465831507986,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09790666952253288,0.12179826695696841,0.7263564310373228,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03924810697199544,0.09676972000320881,0.686445637004377,-0.23268802096970503,0.15419180702571417,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06939009824881157,-0.07243785342970957,0.9631430579652833,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023415363955409736,0.0709376794571922,0.7424495476432432,-0.1183870367639613,0.16521776467478078,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07383369542466885,-0.03108968472438674,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009694830229609945,0.10920661101950005,0.9295467695047834,-0.20860607467011413,0.22799573512933405,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03656430719171679,0.06845195048047348,0.9916960348989801,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0012389435866497478,0.11311855726286735,0.9912964224855216,-0.2273597176030308,0.2248818304297313,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012068686129410798,0.09758794995166592,0.9992761255456871,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09999672852231535,0.22893608780461877,0.6637819689960684,-0.35763999022017023,0.5576334472648009,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03465101128955681,0.28094264443508027,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2751637370648121,0.1623218844190622,0.09505975868947399,-0.5996405606097016,0.04931308648007737,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05679997971194765,-0.004735059387469707,0.6731350262953119,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00021432737130733367,0.07235645181938412,0.9976460963621716,-0.14485281363185418,0.1444241588892395,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020931878085012783,0.027132345835702863,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037366864301088654,0.15495114438746066,0.810232618567013,-0.347109788463349,0.2723760598611717,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.029046846358934553,0.1091840444787493,0.9747331744048557,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04650104944948196,0.13728757724839957,0.7359706114763152,-0.3209350060115524,0.22793290711258846,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03967433396455205,0.09315965804341428,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06069616195750626,0.14637626818766034,0.6798231999366318,-0.35329815283427835,0.2319058289192658,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.003068103789997605,0.10709743181186271,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058351847836702525,0.14543047026148836,0.6896264097843754,-0.34906321559818754,0.23235951992478251,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.048415323564143936,0.022887584296376787,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11024662378297563,0.15322405658475968,0.4745287093346524,-0.4165371486202209,0.19604390105426966,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013991782501316401,0.011732108706162456,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03508279553007374,0.11262095280778829,0.7564563922082138,-0.19004328135385537,0.26020887241400287,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02077910879668249,0.11211657540860762,0.9657045418701836,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2895590793741646,0.20416761239050937,0.1611271294385704,-0.697684321243504,0.11856616249517477,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04624192944622147,-0.0007824214800106602,0.7815068115919459,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11008335746297859,0.171600921394866,0.5235573032991685,-0.4531087116279994,0.23294199670204224,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.14454465912561132,0.15666123956462305,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.28792424736489125,0.14460466030455899,0.05087969477742788,-0.5769848445439919,0.001136349814209403,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09224642318989441,-0.11908269517792311,0.5306536293719093,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007731827478590275,0.20365230153130032,0.9698369135769562,-0.41482697761795273,0.3993633226607721,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06444179796337132,0.1451344704922549,0.9969763314031036,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13266264029921432,0.14712409622522626,0.3707028398770065,-0.4267595181227196,0.16143423752429098,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06114050277770714,0.09124421314515146,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07591146090408941,0.1225740978374671,0.5379808336043217,-0.3209335912072488,0.16911066939907,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01834153459054076,0.045908760169180905,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016162244487214227,0.08649664655751506,0.8523852014059665,-0.15674208830016162,0.1890665772745901,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09608168860917013,-0.007355657474382074,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02500838854505946,0.062498404382671846,0.6904255203737382,-0.14994091876605456,0.09992414167593563,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07711711052961402,-0.03532375969930093,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023942678203249777,0.10311519378323371,0.8171524515792091,-0.23006701354931128,0.18218165714281173,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03104653372909167,0.06144719823515628,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2423068917437126,0.1797390849194628,0.18252993902479167,-0.6016002029953624,0.11698641950793723,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.043782741337671294,0.12090870933956535,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11009727770417968,0.06826520702729293,0.11186974166951473,-0.02636292674776572,0.24655748215612508,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11678226388130832,-0.026008867301973167,0.7058998484678919,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014780968487983095,0.08068390231048593,0.8552420049656139,-0.1760657910897481,0.1465038541137819,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.043175477574509305,0.04256664211151305,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011750327725049511,0.14704022031173478,0.9365643616843726,-0.28217888453642115,0.3056795399865202,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05636320381070241,0.16720325962585847,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028027348809403194,0.10484701632211267,0.7901126196100141,-0.23761354808324017,0.1815588504644338,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.030323056550835035,0.021304727408750137,0.972929334907502,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008890677698723527,0.098047744739209,0.9280415470154535,-0.20488532674176163,0.18710397134431456,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10686937355258165,0.15575986998463615,0.9916764739841218,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01989416895563986,0.08012775671435775,0.8047378153983521,-0.14027893444014133,0.18006727235142106,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007574550203199652,0.04543171720667843,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01541109920243591,0.11568049601166339,0.894449875868082,-0.21583091740117255,0.24665311580604438,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028774247521826807,0.094149179866969,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16598745027419085,0.205125090747469,0.4214940747285074,-0.5760266641072684,0.24405176355888672,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017337438745002088,0.09665037034494828,0.9282753503874777,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09471263072234204,0.21102741426882343,0.6551286995450232,-0.5165504211589232,0.32712515971423917,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02322744688941807,0.036966817829071394,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07949701623124747,0.06844123634058914,0.24987593090128948,-0.05731506580414,0.21630909826663494,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.016225494742567508,0.07286662811742595,0.8577585765822857,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14619556790761537,0.24744799685004812,0.5567932257390833,-0.6408370655578267,0.34844592974259603,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06368159071666105,0.0651603696156164,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025878735367310286,0.13367067233676408,0.847121428988649,-0.29308260203120323,0.24132513129658267,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02121021247406279,0.1292621559368349,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10020002816246397,0.15550310145915824,0.5217187052907083,-0.21064624246474495,0.4110462987896729,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05721974912589716,0.11762116813170369,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10480973046587638,0.1584411324773128,0.510739011133067,-0.4215290414145369,0.21190958048278413,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11381432014120094,0.14372840793199065,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14136166104896417,0.16056663295147097,0.38204667473425913,-0.4623297869049078,0.17960646480697942,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.24761376876031935,-0.1219278798633187,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039227519162834054,0.20009604221313132,0.8452172987268392,-0.43921380821799216,0.360758769892324,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10058230723955926,-0.015414647621948918,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.25476745390885003,0.16091015231224196,0.11844350462197725,-0.5764222651825244,0.06688735736482426,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06444439727630889,0.041613293170478,0.7204222518350135,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2000917247670668,0.15405382442966672,0.19880772243332018,-0.5080409318920315,0.10785748235789785,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007721834024103596,0.03884423115940943,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02989279809637101,0.16867897517529526,0.8599155519517279,-0.3670772649941666,0.30729166880142456,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10580142522485184,0.029467052570757813,0.9841421066021938,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.5447171273485408,0.18795870732159625,0.005184297484179911,0.16899302503425678,0.9204412296628248,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7101736656025317,0.8949319695662747,0.13594586142399853,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.103214681498084,0.12510447640642516,0.41251885260357435,-0.3532949664879022,0.14686560349173422,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10158371871635183,0.14863356719718887,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07301420282943519,0.12348218594742932,0.5564735847432891,-0.3198515753993657,0.17382316974049536,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10122809801838809,0.13263168376263051,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.101671171267613,0.13561027064449105,0.456252482726372,-0.16940989716791233,0.3727522397031383,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12231449913562123,0.06545943818152676,0.9353647231100054,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059443233241858684,0.10832310389991187,0.5851419770783719,-0.2759780325744298,0.15709156609071245,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03385180378461001,0.11138403802490986,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06602115450189834,0.1554294309247978,0.672477685805646,-0.24467785082547944,0.3767201598292761,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.163449686340232,0.034039015732322195,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11285990601842366,0.14496526898320677,0.43921746086778723,-0.176921537638089,0.4026413496749363,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12654003210422132,0.08486537153093038,0.9304126176629784,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0009848903528511493,0.1402504396468373,0.9944195531628703,-0.28134152445828786,0.27937174375258556,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.018395608788377996,0.11534440742299756,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02502179277580166,0.08144016984941249,0.7596892675456415,-0.13777478709553445,0.18781837264713777,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05765330503374837,-0.03694489363659899,0.9673425418314568,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0014763081617271822,0.14650889384321883,0.9919925448785117,-0.2913907976229342,0.2943434139463885,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.035878140176688306,0.13834441222865232,0.9994099232379783,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003390791658563054,0.12743762909938347,0.9788582805465329,-0.25135339910936855,0.25813498242649463,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06776649655070796,-0.002478109699201092,0.9984157213799838,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10514529282170884,0.2672193167838351,0.6953153309615561,-0.6393090958737147,0.429018510230297,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0071412098331762935,0.16336349049370907,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019384689231356653,0.17001459594928187,0.9095921098239536,-0.35923902401390956,0.3204696455511962,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07040162886584947,0.055169347153381884,0.9890879681893895,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13376329671806408,0.168972526158339,0.4315961713917187,-0.4715345636697612,0.20400797023363304,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.062181267621314304,-0.05165454245704134,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09942157757364183,0.18029418831375985,0.5833135416455231,-0.4598245246995,0.26098136955221635,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011636589680701808,0.14873444388606089,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05012120246552843,0.10205223366826235,0.6250665618941066,-0.2541207108180197,0.1538783058869628,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0631297544717126,0.0856989575007451,0.9595394253172342,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03850968453811847,0.19474707721011622,0.8438937936179431,-0.427803544906641,0.35078417583040405,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.20693004962905423,-0.1004086527292983,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050952928561395376,0.26206381526715194,0.8464752974166931,-0.4729051738027384,0.5748110309255291,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11023368094362239,0.11170735307746087,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022459411236110585,0.09094814122855813,0.805764774180529,-0.2042621550791274,0.15934333260690622,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027722112246379528,-0.010004415021734084,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029156526055362758,0.10683994993636933,0.7858377029001461,-0.18441349074871166,0.24272654285943718,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09779164951003136,0.07930491135179514,0.9722536916492144,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11733332650133901,0.0711409871569327,0.10414295456878492,-0.02487548051900687,0.25954213352168487,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09997070060468966,0.0008620164411837869,0.686265063428165,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003237081983013637,0.10045057808111725,0.974395645408977,-0.20403492643670446,0.19756076247067716,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12427277855923903,0.05321728795629081,0.998018743752871,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18446885824672068,0.07344380549624545,0.014633595172734415,0.037656782957186524,0.3312809335362549,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.21027046447538136,-0.03852182043422215,0.2640033601844677,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01865110896217406,0.10097871851210889,0.8540645573334817,-0.18320247317006277,0.2205046910944109,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06834411454795675,0.07381233913328755,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08064227515410524,0.08295902746255927,0.33479122394961425,-0.08519045782434059,0.24647500813255108,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05904809742970551,0.007980839269430917,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01997541203545788,0.09045667970652817,0.8259515958189745,-0.20079573829421893,0.16084491422330316,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04037726343128887,0.014538183840281143,0.980692368074751,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12765499537857133,0.07495232250116651,0.09354859617103183,-0.022172562436760523,0.2774825531939032,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03116379231728132,0.0632887698342806,0.6704521782043941,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054123567910444786,0.08598783833515668,0.531378354853355,-0.22601080755369385,0.11776367173280428,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008428792873180302,0.0007712015212481341,0.9462574637850627,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11891559296132688,0.058237946023784695,0.04542240860600557,0.0024995976492539623,0.23533158827339978,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04707725400195547,0.09238187710492493,0.5099902114773299,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05573414749950035,0.10311714098639715,0.5907931861885415,-0.15039408025022277,0.26186237524922346,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10939175968709679,0.10342344014186775,0.953309951095112,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03944536099642864,0.054611874878194556,0.4728346295728363,-0.06972222137687298,0.14861294336973027,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16784439700398712,-0.12786057645920793,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06378657542911838,0.09824640449900846,0.518574168009047,-0.1326051888153395,0.2601783396735763,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04955356908667467,0.06161989747581141,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05427994573930602,0.0865151407203146,0.5326983488866195,-0.11866135635273747,0.22722124783134953,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006976430400470604,0.01422582320975684,0.9463401736865253,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015404710385094488,0.09188058303671624,0.8673963503105525,-0.1990713788439105,0.1682619580737215,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.006746211294555537,0.027255641474344394,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16367552152226256,0.06304180101073462,0.01175162881555695,0.037656756919317996,0.2896942861252071,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.004572701883183933,0.08331472995938169,0.22587028943799292,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04918108776561486,0.1000159867912322,0.6246451122225671,-0.15074802107804494,0.24911019660927466,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004163212087209344,0.0750224184491134,0.9593389007132584,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06877521761008698,0.10687668773537846,0.5222724830492333,-0.1448682370078052,0.2824186722279792,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07352726016332317,0.025301781781260097,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05839850696479475,0.0954931615318877,0.5430738315459986,-0.2492866169385058,0.13248960300891627,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.34654187676966125,0.34580287050448855,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07362289164793193,0.13522101920720278,0.5880756090911083,-0.19668007425148984,0.3439258575473537,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1396163378422328,-0.12965523220462224,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16736265740409395,0.08494440430423573,0.051782708883527366,-0.3360454095899704,0.0013200947817825492,84,12,96,1,log_other_mut_burden,False,93,-0.17106899328085132,-0.3257489236885929,0.5339911008653665,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022508739613475076,0.08746381202904949,0.7974777851660052,-0.15117705700341344,0.1961945362303636,84,12,96,1,log_other_mut_burden,False,93,-0.21769129121254055,-0.17829149632517816,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10358386022139457,0.07006557347499133,0.1426838826328971,-0.24272020315121295,0.035552482708423816,84,12,96,1,log_other_mut_burden,False,93,-0.3118219192208705,-0.41167480250361327,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04661193861983556,0.10009840233706878,0.6425467501390008,-0.15216365035423382,0.24538752759390495,84,12,96,1,log_other_mut_burden,False,93,0.0890701255378674,0.16875909367323697,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03612199187183379,0.06961268044140688,0.6050633511633994,-0.17435897899385558,0.102114995250188,84,12,96,1,log_other_mut_burden,False,93,-0.18107314438542174,-0.20508101560349942,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10694832334507881,0.06240931902398882,0.08992273458165072,-0.23088086229500313,0.016984215604845504,84,12,96,1,log_other_mut_burden,False,93,-0.4319595850099914,-0.5394095679381474,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012160501914208977,0.09967762507523782,0.9031635870244883,-0.18577950680988103,0.210100510638299,84,12,96,1,log_other_mut_burden,False,93,-0.12101331312883974,-0.09192728996848253,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17763932068482302,0.053984578112560945,0.001413543661517076,-0.28484199384744036,-0.07043664752220567,84,12,96,1,log_other_mut_burden,False,93,-0.4692864127628855,-0.642460169216357,0.048365127522079956,0.4622107861525674 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04664664727061809,0.04683710459148837,0.32186667224736526,-0.13965585454710078,0.046362560005864605,84,12,96,1,log_other_mut_burden,False,93,-0.08793762438574593,-0.12499272987902339,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0465033108408614,0.10449300641392019,0.6573267358026631,-0.16099909088235106,0.2540057125640739,84,12,96,1,log_other_mut_burden,False,93,0.07023335278686804,0.13912837597023156,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0487894882366169,0.05407383550626269,0.36924156313783896,-0.15616940889359096,0.058590432420357164,84,12,96,1,log_other_mut_burden,False,93,-0.20089072320963075,-0.23704220768398718,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08347554616478578,0.11260851217428082,0.46038549582833566,-0.1401426416216848,0.3070937339512564,84,12,96,1,log_other_mut_burden,False,93,0.11983299312438363,0.23147984230391305,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05721209970227209,0.07003373443032554,0.41606078742187946,-0.1962852165994261,0.08186101719488192,84,12,96,1,log_other_mut_burden,False,93,-0.12534855402719122,-0.1698326307532407,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07166481628522882,0.04958370982854172,0.15172655430353496,-0.1701282372247438,0.026798604654286157,84,12,96,1,log_other_mut_burden,False,93,-0.2017942630792491,-0.2664137948947294,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009997011378844761,0.042948672297985296,0.8164542486458631,-0.09528456275192816,0.07529053999423864,84,12,96,1,log_other_mut_burden,False,93,-0.2634626739963085,-0.26962122718715703,0.978118597306197,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045161880900884244,0.06468301465944387,0.4867923460073973,-0.08328576696719689,0.17360952876896538,84,12,96,1,log_other_mut_burden,False,93,-0.915335663886119,-0.8618899957014948,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00219036787661777,0.041924125725126285,0.9584447395807503,-0.08544337280643596,0.08106263705320041,84,12,96,1,log_other_mut_burden,False,93,-0.0055730641352341615,-0.0013541913094554114,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03964394089609169,0.06168483651364506,0.522009611447454,-0.16213780116251353,0.08284991937033016,84,12,96,1,log_other_mut_burden,False,93,-0.22469474530852387,-0.2526853132970546,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010044236818890322,0.06084504874036093,0.9868645671243075,-0.11982178450067976,0.12183063186445783,84,12,96,1,log_other_mut_burden,False,93,-0.04790490679393447,-0.04013982277849546,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09799781652935442,0.06757447209051236,0.15036162181794585,-0.23218732581015505,0.03619169275144622,84,12,96,1,log_other_mut_burden,False,93,-0.20437977167375795,-0.2920294612357119,0.7680634195565342,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11743475041529813,0.0926179444363056,0.20798167672502405,-0.30135563251789443,0.06648613168729817,84,12,96,1,log_other_mut_burden,False,93,-0.12259193487966615,-0.22539963687843004,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08174520410189907,0.09878116575147856,0.4100504336154148,-0.11441461407058258,0.27790502227438074,84,12,96,1,log_other_mut_burden,False,93,-0.2603639333682729,-0.1616215312082113,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14464031925503162,0.06296228800884363,0.023847685347290308,-0.26967094501835753,-0.019609693491705688,84,12,96,1,log_other_mut_burden,False,93,-0.3116920785450022,-0.44994240526129653,0.3634085581572868,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1870530602637654,0.09826495612817919,0.06006006831179393,-0.00808166790218559,0.38218778842971635,84,12,96,1,log_other_mut_burden,False,93,-0.06808067788619818,0.15231556140657884,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011321124853136369,0.05877792615944282,0.8476856124594672,-0.12804243726404274,0.10540018755777002,84,12,96,1,log_other_mut_burden,False,93,-0.20930385173372387,-0.206915082042909,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06223562232277527,0.057520422234390044,0.28206144937310995,-0.17645978115776484,0.051988536512214314,84,12,96,1,log_other_mut_burden,False,93,-0.30763563679791506,-0.3640268186192172,0.8770089248428307,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05859198482283437,0.05472002143668442,0.2870485943665881,-0.16725510267284463,0.05007113302717589,84,12,96,1,log_other_mut_burden,False,93,-0.2953740747685208,-0.34560270254293707,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07896900003655971,0.05329403835834409,0.14178450276611795,-0.1848003981023753,0.0268623980292559,84,12,96,1,log_other_mut_burden,False,93,-0.38403175484579405,-0.45528486055791134,0.7604630965928677,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07685092737482327,0.05680846681316793,0.17939688936303766,-0.18966128384261666,0.035959429092970105,84,12,96,1,log_other_mut_burden,False,93,-0.22273884480428152,-0.29380274503165243,0.7982357106299288,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002293465669319171,0.05400590117551935,0.9662175044956025,-0.10953848220904674,0.10495155087040839,84,12,96,1,log_other_mut_burden,False,93,-0.08274867758386002,-0.06733548277867892,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04448594343306063,0.043975075505047125,0.3143458540369511,-0.13181172815697778,0.04283984129085652,84,12,96,1,log_other_mut_burden,False,93,-0.10205878744266059,-0.1332206336960332,0.9017988396622038,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037486061547595435,0.09812818315696427,0.7033246063557128,-0.23234918569915433,0.15737706260396347,84,12,96,1,log_other_mut_burden,False,93,-0.09697287766231621,-0.12048715529673269,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06321140786386992,0.09976726898232138,0.5279044817476928,-0.13490661589355168,0.2613294316212915,84,12,96,1,log_other_mut_burden,False,93,-0.06678005791587445,0.01869033025975918,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10082077758392123,0.051448114117502435,0.053029634228967226,-0.20298653594312854,0.001344980775286067,84,12,96,1,log_other_mut_burden,False,93,-0.05603695168333719,-0.15184788622210857,0.5410658566960692,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007654741085986145,0.08614318086236777,0.9293837166621708,-0.16340854376402417,0.17871802593599648,84,12,96,1,log_other_mut_burden,False,93,0.027824285723914495,0.048051737021095164,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01989753957103982,0.05929050142289322,0.7379328998140788,-0.13763672487009482,0.09784164572801517,84,12,96,1,log_other_mut_burden,False,93,-0.2958357428720527,-0.3153833389848277,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10359123788367375,0.056086198452599406,0.0679267810078705,-0.21496731253060555,0.007784836763258057,84,12,96,1,log_other_mut_burden,False,93,-0.15463682103999252,-0.24089991397565347,0.6004485385751404,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10420280317213396,0.04756044401230386,0.030953979127291087,-0.19864841918285991,-0.009757187161407999,84,12,96,1,log_other_mut_burden,False,93,-0.3971829502465941,-0.5008295643408406,0.42002168600416523,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09904305054314654,0.041522793225671234,0.019094934759786155,-0.18149908866739095,-0.016587012418902133,84,12,96,1,log_other_mut_burden,False,93,-0.2808907677442375,-0.37403330106482896,0.3154853684987219,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043199896870675346,0.04819453955154424,0.372372271642451,-0.13890470095369345,0.05250490721234275,84,12,96,1,log_other_mut_burden,False,93,-0.17876873805949706,-0.21827370790980508,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06830340909216802,0.04015886538813299,0.09231650226225599,-0.1480509568419922,0.011444138657656172,84,12,96,1,log_other_mut_burden,False,93,-0.2706294476661587,-0.3319071629494129,0.6674195391201606,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020918627082670956,0.04669230598048525,0.6551878089282539,-0.1136402930147089,0.071803038849367,84,12,96,1,log_other_mut_burden,False,93,-0.02580521232672092,-0.03352055215629473,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08065330440709634,0.05371976296772532,0.13664730316976317,-0.18733010717463286,0.026023498360440184,84,12,96,1,log_other_mut_burden,False,93,-0.0938655119226463,-0.174285612814849,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03095525245657174,0.04659731727061354,0.5081331009304281,-0.12348828963620408,0.061577784723060594,84,12,96,1,log_other_mut_burden,False,93,-0.1738832615056302,-0.19747711466480056,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02583129244753763,0.05062003720392118,0.6110519215837702,-0.1263526541693374,0.07469006927426211,84,12,96,1,log_other_mut_burden,False,93,-0.13274779899765918,-0.15724543295225626,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07308906623940681,0.03725424783580493,0.0527641314108939,-0.1470686191838372,0.000890486705023591,84,12,96,1,log_other_mut_burden,False,93,-0.10485862750626869,-0.1720086202078193,0.5404408711479688,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047092412353522704,0.04592806177579142,0.3078569443985932,-0.13829644075727637,0.04411161605023096,84,12,96,1,log_other_mut_burden,False,93,-0.047254526147520584,-0.08481107109657647,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0803156932476203,0.03716097181144648,0.03324110379514376,-0.15411001849364472,-0.00652136800159589,84,12,96,1,log_other_mut_burden,False,93,-0.011701577606875135,-0.08525995555540973,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07892738142492114,0.0432502247466216,0.07122632689320343,-0.16481375619762695,0.006958993347784659,84,12,96,1,log_other_mut_burden,False,93,-0.07481890367261612,-0.15111538069168548,0.6185936355341891,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07834399959093265,0.04507964088279564,0.08553811449549718,-0.16786323224604638,0.011175233064181084,84,12,96,1,log_other_mut_burden,False,93,-0.17150254760359548,-0.24540501233808384,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12658380980770745,0.037016853254204785,0.0009327474220736267,-0.2000919441612804,-0.0530756754541345,84,12,96,1,log_other_mut_burden,False,93,-0.15274226853605266,-0.27433704472799714,0.03412050247198364,0.3260792450985756 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04497814541113532,0.03796080996932394,0.23909288036733015,-0.12036079072225582,0.030404499899985185,84,12,96,1,log_other_mut_burden,False,93,-0.5824440248408489,-0.6209272585834306,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007421682691787779,0.10845544590279922,0.9455896946711723,-0.22279270394125178,0.20794933855767622,84,12,96,1,log_other_mut_burden,False,93,-0.18503503004758454,-0.18036841453997188,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017385884839690183,0.0582150849115658,0.7658740579033813,-0.1329895060793737,0.09821773639999336,84,12,96,1,log_other_mut_burden,False,93,-0.2604458957898976,-0.26750542475416045,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-7.301518693599712e-05,0.060800507233444406,0.999044394767282,-0.12081077276425625,0.12066474239038427,84,12,96,1,log_other_mut_burden,False,93,-0.09538322997059985,-0.0909991848691291,0.9996899238181953,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04960864675617103,0.06271179043265367,0.43092310672687706,-0.17414183397820973,0.07492454046586766,84,12,96,1,log_other_mut_burden,False,93,-0.050567197122945384,-0.08402835931511844,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0815033995486371,0.05129443231230762,0.11546962907829716,-0.18336397630025658,0.0203571772029824,84,12,96,1,log_other_mut_burden,False,93,-0.22006301395819597,-0.2934985995164024,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19992749039670038,0.09757281171126321,0.04327853998886876,0.00616722386965049,0.39368775692375024,84,12,96,1,log_other_mut_burden,False,93,0.07154392194013821,0.2886845991773413,0.4971708399879019,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006778609802984489,0.055553679686483094,0.9031471711485248,-0.10353998811202035,0.11709720771798933,84,12,96,1,log_other_mut_burden,False,93,-0.04977723791937164,-0.026782841623621764,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04542385030556338,0.054687299792795525,0.4083209499649044,-0.15402198945577072,0.06317428884464395,84,12,96,1,log_other_mut_burden,False,93,0.021309075894354785,-0.013300030503964333,0.9252788183903543,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05620796903476333,0.04730186516211738,0.23774788529338226,-0.15014009869563752,0.037724160626110864,84,12,96,1,log_other_mut_burden,False,93,-0.34950172529850143,-0.4021267014208448,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020258196995914655,0.047583998270859205,0.6712842336639846,-0.11475058709601538,0.07423419310418608,84,12,96,1,log_other_mut_burden,False,93,0.08628470405116156,0.0784270851258162,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06853778359391442,0.059161521424136644,0.24963207013654806,-0.18602084017742426,0.04894527298959543,84,12,96,1,log_other_mut_burden,False,93,-0.2021758681664732,-0.26345259647005,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014579822289522409,0.09365380618211135,0.8766243760440007,-0.2005577205263512,0.1713980759473064,84,12,96,1,log_other_mut_burden,False,93,-0.01587723114867832,-0.011794808164724913,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08474100859985187,0.07664200031983802,0.27172008548462223,-0.23693683189007939,0.06745481469037565,84,12,96,1,log_other_mut_burden,False,93,-0.2546436944130162,-0.3290166554926734,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08076418693860515,0.058028844292237244,0.16730465671891392,-0.19599797121852114,0.034469597341310845,84,12,96,1,log_other_mut_burden,False,93,-0.35599028075880074,-0.4323188145290728,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05781878255102116,0.07328862213072924,0.4321659683557596,-0.20335546134912877,0.08771789624708645,84,12,96,1,log_other_mut_burden,False,93,-0.10862826013039914,-0.15751271570156433,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11166118042203871,0.05211911140742749,0.03477118780557981,-0.21515940641700032,-0.008162954427077096,84,12,96,1,log_other_mut_burden,False,93,-0.570601670198783,-0.679935081625807,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04227772152358289,0.07045597412322308,0.54992645862021,-0.18218932276898164,0.09763387972181586,84,12,96,1,log_other_mut_burden,False,93,-0.4050943579686868,-0.4388411210072621,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13398215566729202,0.06721493528820743,0.04915438461939223,-0.2674576961137515,-0.0005066152208325903,84,12,96,1,log_other_mut_burden,False,93,-0.4606546843534967,-0.5926450092682257,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06679493234181105,0.04171447167824619,0.11271503566659365,-0.1496316058849498,0.016041741201327703,84,12,96,1,log_other_mut_burden,False,93,0.027900913623520197,-0.029240468865040045,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07777696707954956,0.04855331669087149,0.11257179991279678,-0.17419423145678953,0.018640297297690386,84,12,96,1,log_other_mut_burden,False,93,-0.11348366212469228,-0.1861234545803354,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09514217553240058,0.05738048711579737,0.10066814224449949,-0.20908845095499815,0.01880409989019699,84,12,96,1,log_other_mut_burden,False,93,-0.193326172366606,-0.28371997605012783,0.6818291067720451,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0034351050578327394,0.08381789482052718,0.9673973400418132,-0.16301062255141752,0.16988083266708298,84,12,96,1,log_other_mut_burden,False,93,-0.028989447505874986,0.001238796184187137,0.9962636332708761,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08781263903367358,0.056563217613742126,0.12394662123177332,-0.20013597919628032,0.024510701128933166,84,12,96,1,log_other_mut_burden,False,93,-0.3486857378454895,-0.4337900682413198,0.7255813269452924,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008385437328658343,0.06404025462536957,0.8961055262882127,-0.13555669115488575,0.11878581649756906,84,12,96,1,log_other_mut_burden,False,93,0.06065192250375106,0.07369638552768502,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04809617738059258,0.047744541357175006,0.3163732645767009,-0.1429073742327799,0.04671501947159474,84,12,96,1,log_other_mut_burden,False,93,-0.03946706762018714,-0.07832547394329818,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03806268718126118,0.04813708605997029,0.431122476653811,-0.13365340001647122,0.05752802565394886,84,12,96,1,log_other_mut_burden,False,93,0.032013421147336976,0.008830221070136738,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029038458542504794,0.03923135408420427,0.4610523199306228,-0.10694415266216106,0.048867235577151474,84,12,96,1,log_other_mut_burden,False,93,-0.09101123586344492,-0.11164885676670949,0.9369772953428787,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0795540338141871,0.033711567311564786,0.020373050631303985,-0.1464985253459338,-0.012609542282440406,84,12,96,1,log_other_mut_burden,False,93,-0.005478152428608799,-0.08492174162749422,0.3287017803075021,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045420724745154045,0.05434833063556193,0.405446846501181,-0.15334573832791962,0.06250428883761153,84,12,96,1,log_other_mut_burden,False,93,-0.06527999088287617,-0.09385102981422384,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09726848205817179,0.04137750229431443,0.020847865621533426,-0.17943600118731984,-0.015100962929023728,84,12,96,1,log_other_mut_burden,False,93,-0.03233357920939479,-0.12261891171668358,0.3333341305877653,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0845663411984138,0.03905247932757517,0.03291156697144645,-0.16211682550181533,-0.0070158568950122735,84,12,96,1,log_other_mut_burden,False,93,-0.10257715201461604,-0.1811091313511094,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011139089773282276,0.03374036327754655,0.7420356763707294,-0.05586258483995686,0.07814076438652141,84,12,96,1,log_other_mut_burden,False,93,-0.018062829451401984,-0.00830641808794534,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0679218294853979,0.049463818272804765,0.17300373616881942,-0.1661471695560057,0.030303510585209886,84,12,96,1,log_other_mut_burden,False,93,-0.14244352685147166,-0.20121199670034082,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09430304488233873,0.04688408365589025,0.047176674804939464,-0.18740554327014697,-0.0012005464945305105,84,12,96,1,log_other_mut_burden,False,93,-0.11292907411290805,-0.2014446033574442,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10569471162289447,0.08748057719979846,0.23003065494123692,-0.2794138005462741,0.06802437730048518,84,12,96,1,log_other_mut_burden,False,93,0.296659510208795,0.2171661377662696,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04993607626947049,0.062044328339629265,0.42296187572448163,-0.17314381605617427,0.0732716635172333,84,12,96,1,log_other_mut_burden,False,93,-0.06453511234671748,-0.0955159516207222,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012196063361525483,0.05653830600303223,0.8296836506350023,-0.12446993400238625,0.10007780727933528,84,12,96,1,log_other_mut_burden,False,93,-0.08961735810820853,-0.08422750697277771,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07088236857567809,0.032411774128037,0.03125585203350397,-0.13524572844530097,-0.006519008706055193,84,12,96,1,log_other_mut_burden,False,93,-0.23841385146954833,-0.303951878725399,0.42195400245230363,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049851412638184794,0.07651967493693748,0.5163402132711191,-0.20180432196110787,0.10210149668473828,84,12,96,1,log_other_mut_burden,False,93,0.053206839621024384,0.01873001884229213,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08786079330523246,0.05275964242177916,0.09921769783624719,-0.1926309869506384,0.016909400340173478,84,12,96,1,log_other_mut_burden,False,93,-0.08958157915800298,-0.16917115928921034,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008972740049037933,0.06053662430011872,0.8824900281598359,-0.12918647841858516,0.11124099832050928,84,12,96,1,log_other_mut_burden,False,93,-0.13681569422431628,-0.13198859333403465,0.9870366109823806,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07801944130222492,0.05364206658224645,0.14918972880576709,-0.1845419544465094,0.028503071842059538,84,12,96,1,log_other_mut_burden,False,93,-0.1940130907485194,-0.2642697322225928,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02093355317288309,0.061293514096135,0.7334753619812884,-0.1007832183268531,0.1426503246726193,84,12,96,1,log_other_mut_burden,False,93,-0.038059371610826676,0.00164830975372974,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06146563987406009,0.050969563877146566,0.23090421501304464,-0.16268109229771308,0.039749812549592894,84,12,96,1,log_other_mut_burden,False,93,-0.5647761122042745,-0.627846732674855,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07959339104921503,0.05857382576164863,0.17747878000233863,-0.19590940051987302,0.03672261842144295,84,12,96,1,log_other_mut_burden,False,93,-0.49459857439678356,-0.5732251434242214,0.7937051017794727,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07239616816697028,0.06539712716733301,0.2711388493133287,-0.2022619019488647,0.05746956561492414,84,12,96,1,log_other_mut_burden,False,93,-0.04525488091590166,-0.10114118000792778,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007181029739035533,0.057437856865458915,0.9007755190466524,-0.12124123011459956,0.10687917063652849,84,12,96,1,log_other_mut_burden,False,93,-0.09041279552041476,-0.0851697319924195,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0891390848219129,0.06272621760890638,0.15863744871310706,-0.21370092155673015,0.035422751912904324,84,12,96,1,log_other_mut_burden,False,93,-0.3943500552009169,-0.48023761636582635,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0699578101584046,0.05701066460736299,0.22288217481764452,-0.18316969137276723,0.043254071055958035,84,12,96,1,log_other_mut_burden,False,93,-0.14441628266144643,-0.2084204348452192,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038526068312722164,0.05014994911402542,0.44430430017610256,-0.13811392825270458,0.061061791627260234,84,12,96,1,log_other_mut_burden,False,93,-0.05493847922673524,-0.09628790348822018,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08322735525638046,0.04924582406405302,0.09437004401739779,-0.18101980203173215,0.01456509151897123,84,12,96,1,log_other_mut_burden,False,93,-0.31480675364303207,-0.3983424561549462,0.6712449905108455,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06260523539340118,0.042111064099744314,0.14048460025357715,-0.1462294628867067,0.02101899209990435,84,12,96,1,log_other_mut_burden,False,93,-0.42409737785770363,-0.4894988037048036,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08933684812793852,0.0579923781311112,0.12683604055249556,-0.2044982178389282,0.025824521583051152,84,12,96,1,log_other_mut_burden,False,93,-0.2495418512184472,-0.3354709629854704,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0625311914471749,0.05366555558833513,0.24691735307663853,-0.16910034910236743,0.04403796620801764,84,12,96,1,log_other_mut_burden,False,93,-0.5186372862422702,-0.576866199002649,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07636798195428776,0.048602012609278204,0.11951087553996839,-0.17288194677465102,0.020145982866075482,84,12,96,1,log_other_mut_burden,False,93,-0.2709831194196774,-0.3476664587450247,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07030614295032495,0.0480141462106896,0.14648971274910155,-0.165652721609778,0.025040435709128103,84,12,96,1,log_other_mut_burden,False,93,-0.42333781377648755,-0.4936553276219838,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04032455555043189,0.038575846437580205,0.29857911518885666,-0.11692854139610454,0.03627943029524075,84,12,96,1,log_other_mut_burden,False,93,-0.024629920647223094,-0.06214884981651137,0.8856954470736713,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06082310422150557,0.031843278439046455,0.05920480015185282,-0.12405754432048326,0.0024113358774721233,84,12,96,1,log_other_mut_burden,False,93,-0.16829972670668253,-0.22448730606053804,0.5675938449340672,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09101626156815934,0.05037420939874721,0.07402695176134311,-0.19104945798842798,0.009016934852109304,84,12,96,1,log_other_mut_burden,False,93,-0.09724314220186178,-0.18750856935186822,0.6242218401318658,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08174886129894987,0.054052795197854886,0.1338257495037453,-0.1890870000733133,0.025589277475413577,84,12,96,1,log_other_mut_burden,False,93,-0.19060340246300414,-0.2660937210604217,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09971409222515877,0.09201239015311385,0.28129813546886895,-0.28243246353350804,0.08300427908319048,84,12,96,1,log_other_mut_burden,False,93,-0.26851913735600264,-0.35931772848866766,0.8768618853741261,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12575007327139298,0.06952061668918937,0.07371080471581604,-0.012304093484439782,0.26380424002722574,84,12,96,1,log_other_mut_burden,False,93,-0.14516801689018044,-0.0024962090759605058,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07493177554257649,0.0576746364997948,0.1970817119501635,-0.18946217334560483,0.03959862226045187,84,12,96,1,log_other_mut_burden,False,93,-0.3674298820033541,-0.4489573355742124,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05908390500496843,0.04655618164170059,0.20757656165151422,-0.15153525497807116,0.03336744496813431,84,12,96,1,log_other_mut_burden,False,93,-0.07801911297633611,-0.1264830498904971,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08169667040696646,0.05350273935850437,0.13016433147474454,-0.18794250729755613,0.024549166483623222,84,12,96,1,log_other_mut_burden,False,93,-0.33942066168108487,-0.4151196814684279,0.7333906673033306,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06349150279898866,0.04942348087860245,0.2021078792235189,-0.1616367407990035,0.03465373520102619,84,12,96,1,log_other_mut_burden,False,93,-0.129180462158808,-0.18218115119561076,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08609227878567347,0.05322614837228596,0.10916149754257626,-0.19178886079399893,0.019604303222651984,84,12,96,1,log_other_mut_burden,False,93,-0.1460985700247842,-0.22403844151570465,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08284847674457654,0.05304392110436876,0.12171181980288268,-0.18818319151364873,0.022486238024495647,84,12,96,1,log_other_mut_burden,False,93,-0.12358679394567565,-0.19351842891815504,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10398423972176314,0.06356385824986925,0.10524021105936186,-0.2302094647611742,0.02224098531764794,84,12,96,1,log_other_mut_burden,False,93,-0.3242309194699928,-0.4220490904784917,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05663065059641311,0.06236482286885272,0.3661965510922317,-0.06721352780791051,0.18047482900073675,84,12,96,1,log_other_mut_burden,False,93,-0.03606159025551585,0.045697158744477606,0.914684777397777,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04771305342714055,0.07190342799269661,0.5086063309753177,-0.19049901119272175,0.09507290433844065,84,12,96,1,log_other_mut_burden,False,93,-0.26169737485787675,-0.28890175418949066,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1308222421408441,0.07623835271815209,0.08949824206845103,-0.020572017009599153,0.28221650129128734,84,12,96,1,log_other_mut_burden,False,93,0.000552020077742188,0.16200545948736458,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10069908791902772,0.09053411561113141,0.2688856815114159,-0.280481898959807,0.07908372312175156,84,12,96,1,log_other_mut_burden,False,93,-0.3044493193850772,-0.39283232658900236,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02197750596140726,0.05366896103918474,0.6831135082882057,-0.0845984142442611,0.12855342616707563,84,12,96,1,log_other_mut_burden,False,93,-0.08015546902811613,-0.03561790950085488,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06873750338035843,0.05186120622806848,0.1882811370478481,-0.17172358080221972,0.034248574041502874,84,12,96,1,log_other_mut_burden,False,93,-0.3110519699353331,-0.3798967315939685,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12550824450633205,0.05297829937368722,0.019901758571752148,-0.23071264752355633,-0.02030384148910777,84,12,96,1,log_other_mut_burden,False,93,-0.44957520924960503,-0.5704927343930098,0.32372983512821424,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030952497114751176,0.0420406855295782,0.4634310279933068,-0.11443696671572977,0.052531972486227416,84,12,96,1,log_other_mut_burden,False,93,-0.1690777005717708,-0.19651960306200297,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05285200710528497,0.04972439058780668,0.29057994461926323,-0.15159479215179184,0.045890777941221914,84,12,96,1,log_other_mut_burden,False,93,-0.23841316250417482,-0.27969442860794574,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10846706895294089,0.08533962885525626,0.20689694163558928,-0.061000520863426166,0.27793465876930795,84,12,96,1,log_other_mut_burden,False,93,-0.10287677030150995,0.026417086469345777,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08860307824482089,0.06090749917999291,0.14911500466024163,-0.20955330062371758,0.032347144134075786,84,12,96,1,log_other_mut_burden,False,93,-0.06052071952903334,-0.15070069203612077,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09848180603636444,0.0411991779337819,0.01884666897206492,-0.18029520832682494,-0.016668403745903934,84,12,96,1,log_other_mut_burden,False,93,-0.14291136769024898,-0.24206330607996676,0.3146632024742357,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04088125289166887,0.06805690802314199,0.5495061793552002,-0.17602878432279107,0.09426627853945331,84,12,96,1,log_other_mut_burden,False,93,-0.06576266570079042,-0.10049217391622367,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06171583198575997,0.05172748755877472,0.23586690128958987,-0.16443637063152583,0.04100470666000587,84,12,96,1,log_other_mut_burden,False,93,-0.0956665373369672,-0.15420740486174186,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037621775593154605,0.06530720928345252,0.565956778953226,-0.167308950278097,0.09206539909178779,84,12,96,1,log_other_mut_burden,False,93,-0.15651760492732253,-0.19402481297820892,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07296489537176844,0.03602394895633782,0.045686611985499746,-0.14450131856916543,-0.0014284721743714618,84,12,96,1,log_other_mut_burden,False,93,-0.2610711149882552,-0.32929094177201407,0.5122320987865776,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10504243354740685,0.04856607761393223,0.0331152727112229,-0.20148503858881356,-0.008599828506000148,84,12,96,1,log_other_mut_burden,False,93,-0.09199926838962814,-0.1910162313744113,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00907537224963317,0.07377463189748443,0.902360827649688,-0.13742642562508667,0.15557717012435301,84,12,96,1,log_other_mut_burden,False,93,-0.04449513131265939,-0.019854136638506364,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00400799239833554,0.06601078219548838,0.951714693442554,-0.13509232344852334,0.12707633865185225,84,12,96,1,log_other_mut_burden,False,93,-0.09652576586750863,-0.08861092526400305,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002558884787906293,0.04109044823310059,0.9504779251691743,-0.08415637144148058,0.079038601865668,84,12,96,1,log_other_mut_burden,False,93,-0.13573057410253916,-0.14006857876888226,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04399844757789569,0.09154031110095108,0.6318971704070244,-0.22577936344794547,0.13778246829215407,84,12,96,1,log_other_mut_burden,False,93,-0.08678173712139911,-0.11173237304536521,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08249587303643693,0.06720128263077228,0.22269770694357566,-0.215944302010991,0.05095255593811712,84,12,96,1,log_other_mut_burden,False,93,-0.23479780172390025,-0.30841749205348984,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10193812752666129,0.057262025566209795,0.07830836237674411,-0.2156491617891576,0.011772906735835045,84,12,96,1,log_other_mut_burden,False,93,-0.38464451793903204,-0.47992945271782395,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07468379302767499,0.09005150083380437,0.40903267289918643,-0.2535082267680081,0.10414064071265815,84,12,96,1,log_other_mut_burden,False,93,-0.0867856704096999,-0.1512783421999346,0.9256023179739352,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07052002094033247,0.050560712002934105,0.1664109736622526,-0.17092357457037566,0.029883532689710723,84,12,96,1,log_other_mut_burden,False,93,-0.23696084499375747,-0.2947514612283803,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04163448219911804,0.07567634343960931,0.583525125014223,-0.19191270230455187,0.10864373790631578,84,12,96,1,log_other_mut_burden,False,93,-0.17640227981373607,-0.20252732660673647,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017930408425813914,0.0686329794693715,0.7944769213114352,-0.11836108672842363,0.15422190358005147,84,12,96,1,log_other_mut_burden,False,93,-0.1168804172466067,-0.08380985873612619,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058241246275968564,0.07764043926757429,0.4550636263252208,-0.09593727888818716,0.2124197714401243,84,12,96,1,log_other_mut_burden,False,93,0.0010235034586560626,0.08197005482269533,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15480006040758543,0.06919786368771574,0.027671311265944954,-0.2922133036675063,-0.017386817147664546,84,12,96,1,log_other_mut_burden,False,93,-0.14786563218101711,-0.3000458336087054,0.3929425202666745,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07294957038087913,0.038337446009411316,0.06015650016644444,-0.14908014022375315,0.0031809994619949183,84,12,96,1,log_other_mut_burden,False,93,-0.490134052263612,-0.5717798435378952,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009318249773278262,0.05714297072574718,0.870817896132901,-0.10415636517102075,0.12279286471757728,84,12,96,1,log_other_mut_burden,False,93,-0.06829090362330897,-0.047403607009742055,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04004587820254561,0.05486494863427761,0.4672863844323596,-0.14899679274448452,0.06890503633939328,84,12,96,1,log_other_mut_burden,False,93,-0.04837626835781109,-0.0775993160417892,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13944907186356756,0.06613490134378762,0.03767124962135071,-0.2707798789436431,-0.008118264783492063,84,12,96,1,log_other_mut_burden,False,93,-0.37586237464585015,-0.517872886961284,0.46506124338146493,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00675483443689294,0.04500026988114339,0.8810056389952456,-0.0961164520129192,0.08260678313913332,84,12,96,1,log_other_mut_burden,False,93,-0.1709601678857523,-0.17075109857709506,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1570376876798249,0.06240920411039547,0.013574358219767246,-0.28096999843412707,-0.03310537692552275,84,12,96,1,log_other_mut_burden,False,93,-0.23696552297277124,-0.3893608758597902,0.2505889663918893,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1581703802244789,0.06740713029590588,0.02107407081959824,-0.29202758186593414,-0.024313178583023703,84,12,96,1,log_other_mut_burden,False,93,-0.33420481509091776,-0.4915221726482594,0.33504311408065957,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020675670891391894,0.047923257569213756,0.6671520931828042,-0.11584176272169878,0.07449042093891499,84,12,96,1,log_other_mut_burden,False,93,-0.007988015207734057,-0.020969325210221056,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0943986134958485,0.05975054781682954,0.11753001007324648,-0.21305135975866546,0.024254132766968486,84,12,96,1,log_other_mut_burden,False,93,-0.010369762037906663,-0.10296644061689288,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03431464038670455,0.05023814232586868,0.4962798873141161,-0.1340776345667783,0.06544835379336918,84,12,96,1,log_other_mut_burden,False,93,-0.1436730866162772,-0.17468470314777107,0.9429080290807693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08546862226298002,0.05291921013113237,0.1096816741194757,-0.19055568575513054,0.019618441229170516,84,12,96,1,log_other_mut_burden,False,93,-0.28411283325932135,-0.3580617035407963,0.6987504796661628,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060212742851956644,0.10764964502526418,0.5772743331482839,-0.2739836032568101,0.15355811755289683,84,12,96,1,log_other_mut_burden,False,93,-0.149867548257908,-0.1911034267160943,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09390933465293651,0.06390087163164367,0.14504241147397623,-0.22080380147733403,0.032985132171461026,84,12,96,1,log_other_mut_burden,False,93,-0.3440756689559399,-0.4261382063188579,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1096878931691021,0.06961920932766237,0.11852752089903347,-0.2479378453652957,0.028562059027091496,84,12,96,1,log_other_mut_burden,False,93,-0.15335497155322284,-0.24466177474183878,0.7204222518350135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03936508725830254,0.0985740719222516,0.6905544295596326,-0.23511365812896542,0.15638348361236035,84,12,96,1,log_other_mut_burden,False,93,-0.27326347538839896,-0.2972723050395879,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014774483243219769,0.04721621112705465,0.7550487242553324,-0.10853652096586035,0.07898755447942081,84,12,96,1,log_other_mut_burden,False,93,-0.1887848400736001,-0.19639504065617444,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0667183107473554,0.0676255843924879,0.32640653037963197,-0.20100931893015447,0.06757269743544367,84,12,96,1,log_other_mut_burden,False,93,-0.5988886058276313,-0.6521102505153485,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07159396672518512,0.0883100161272297,0.41960105551760163,-0.2469601569755468,0.10377222352517657,84,12,96,1,log_other_mut_burden,False,93,0.03681861463624263,-0.012940972970022445,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028766297946334243,0.04029643610864641,0.47709717644698657,-0.10878703388255484,0.05125443798988635,84,12,96,1,log_other_mut_burden,False,93,-0.1303682222275707,-0.1527242064445469,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06004262659563538,0.041552792898652144,0.15182679584890899,-0.14255823812491505,0.022472984933644295,84,12,96,1,log_other_mut_burden,False,93,-0.10620694835953867,-0.16243013973672366,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07133151175006665,0.045077459155384164,0.11694854851650802,-0.16084641192692828,0.01818338842679497,84,12,96,1,log_other_mut_burden,False,93,-0.20619760762730047,-0.27206480565777796,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07573944430041796,0.03307921432582055,0.02430418572623027,-0.14142820812576676,-0.010050680475069157,84,12,96,1,log_other_mut_burden,False,93,-0.13842008248749366,-0.20842001438392352,0.36818058453209135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06687743662878498,0.05839671291348659,0.2550541346111913,-0.1828417350842188,0.049086861826648856,84,12,96,1,log_other_mut_burden,False,93,-0.25210645891038136,-0.31167959246804083,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05333721442887452,0.03791867588541568,0.16287261424059735,-0.1286361897997242,0.021961760941975154,84,12,96,1,log_other_mut_burden,False,93,-0.1213903380095405,-0.16968880893515534,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06803282289972035,0.03906522051766527,0.08489924519960451,-0.14560860868151973,0.009542962882079037,84,12,96,1,log_other_mut_burden,False,93,-0.17639704634051917,-0.23845508954751082,0.652400976180504,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06753546233989736,0.04587828997235265,0.1443815420527001,-0.15864065380607906,0.023569729126284328,84,12,96,1,log_other_mut_burden,False,93,-0.0824283947212017,-0.14421383170284707,0.7635967032883216,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059954829223249094,0.03985758784227903,0.13591172459709988,-0.13910409947589483,0.019194441029396637,84,12,96,1,log_other_mut_burden,False,93,-0.11580486096955347,-0.17233153288414957,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10053233461743541,0.056286782516373,0.07734646188817497,-0.2123067294621377,0.01124206022726687,84,12,96,1,log_other_mut_burden,False,93,-0.06413341096528663,-0.1620996489363864,0.6316627720867622,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07940506693840499,0.03467932618447687,0.02430079574016432,-0.14827133579582977,-0.01053879808098021,84,12,96,1,log_other_mut_burden,False,93,-0.1569417752279394,-0.2368382743052088,0.36818058453209135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07521735741214466,0.036254468151068975,0.040776312119570855,-0.14721154604468029,-0.0032231687796090286,84,12,96,1,log_other_mut_burden,False,93,-0.07602391967544254,-0.14907466585609244,0.4874734421764359,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10347571051803972,0.04927399723756588,0.038435486895936746,-0.2013241036324691,-0.0056273174036103185,84,12,96,1,log_other_mut_burden,False,93,-0.20292943820712084,-0.3043104100134367,0.4724959974258181,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03902746650231479,0.04073848685824118,0.3405466891859984,-0.11992602761911361,0.041871094614484024,84,12,96,1,log_other_mut_burden,False,93,-0.13255411989012086,-0.16610874324925642,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045426931221775255,0.049591720265615404,0.36202639692487615,-0.14390625930176487,0.05305239685821435,84,12,96,1,log_other_mut_burden,False,93,-0.02386269607729779,-0.06941503058077662,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08294303640432253,0.04875956297280957,0.09227279857124356,-0.1797698650224372,0.013883792213792143,84,12,96,1,log_other_mut_burden,False,93,-0.08027111761629342,-0.1581442970380942,0.6674195391201606,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055186941290723004,0.03236023355497324,0.09145910359080872,-0.11944795179684346,0.009074069215397454,84,12,96,1,log_other_mut_burden,False,93,-0.11680510656823843,-0.1681187552812339,0.6648373299485711,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09819356889642328,0.044168645392944655,0.028628128668215465,-0.18590374505493007,-0.010483392737916486,84,12,96,1,log_other_mut_burden,False,93,-0.10761100625328442,-0.2000113322545325,0.4029256832771177,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07364389088560984,0.03663249097162571,0.04729132312409577,-0.14638875792107114,-0.0008990238501485198,84,12,96,1,log_other_mut_burden,False,93,0.024349808190608262,-0.03877543312062609,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08859170214852863,0.04394876999169316,0.04670698219867746,-0.17586524933630016,-0.001318154960757087,84,12,96,1,log_other_mut_burden,False,93,-0.34865164915103036,-0.4308060568324407,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10918244178897363,0.05104580940441374,0.035062629735076956,-0.2105493027190095,-0.007815580858937729,84,12,96,1,log_other_mut_burden,False,93,-0.26168448369757347,-0.3693180623682233,0.4493241481738629,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19203913535854056,0.2079088848548036,0.359485174568031,-0.6082139852815396,0.2241357145644584,54,7,61,1,log_other_mut_burden,False,58,0.06664753867390541,-0.030399900623994065,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02016225948578652,0.21542292789812484,0.9257543703062419,-0.4513781007452215,0.4110535817736484,54,7,61,1,log_other_mut_burden,False,58,-0.08739281915141842,0.0332366725440871,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.102241371250394,0.1432964406688873,0.47840042098978364,-0.38908036195308615,0.18459761945229813,54,7,61,1,log_other_mut_burden,False,58,-0.0309014818879966,-0.028720532375186496,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004454261880410326,0.2352522808844856,0.9849587578188365,-0.47536286571193115,0.4664543419511105,54,7,61,1,log_other_mut_burden,False,58,-0.021779804805597994,0.19789242630499398,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04611662689019251,0.13695953235937458,0.7375454530665191,-0.3202709174343078,0.22803766365392275,54,7,61,1,log_other_mut_burden,False,58,0.034523461553496435,0.1244131124091071,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1271632186597923,0.11775050956550075,0.2846402935580157,-0.36286647242406594,0.10854003510448135,54,7,61,1,log_other_mut_burden,False,58,-0.023965752378989617,-0.036400934298445924,0.877125252431494,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14809869912660184,0.18524973419173793,0.4272890435964205,-0.5189163309914611,0.22271893273825744,54,7,61,1,log_other_mut_burden,False,58,-0.06290457978128759,0.008678685791033813,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10615211614023692,0.12469927695563063,0.3981232342838278,-0.3557648390825918,0.14346060680211797,54,7,61,1,log_other_mut_burden,False,58,0.05518760901200213,0.014636608485233469,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07750735371411877,0.11828392195330946,0.5148875855123979,-0.3142783483813288,0.15926364095309126,54,7,61,1,log_other_mut_burden,False,58,-0.010920792004324189,-0.00011970919412897439,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06698543274866882,0.18062240187307832,0.7120937231084302,-0.42854045260631685,0.29456958710897924,54,7,61,1,log_other_mut_burden,False,58,-0.06170024629751237,0.09908573600968915,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06562518142750752,0.1472709114815559,0.6575389357459035,-0.3604199398461433,0.22916957699112828,54,7,61,1,log_other_mut_burden,False,58,0.06014237260974397,0.10490311022630298,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039831337380269734,0.19343391233519838,0.8375768049212418,-0.4270313817282531,0.34736870696771366,54,7,61,1,log_other_mut_burden,False,58,-0.07007293265840926,0.09544741891615405,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08587363600197993,0.15078072689797356,0.57119811223208,-0.38769405330578144,0.21594678130182154,54,7,61,1,log_other_mut_burden,False,58,0.01445195704535277,0.05962156314618602,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06123311370965825,0.12324382136528468,0.6211762189979428,-0.30793242574942076,0.18546619833010425,54,7,61,1,log_other_mut_burden,False,58,-0.021298045131773375,0.020666954795237193,0.9582992440631078,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07119196087180608,0.20346453990675956,0.7276821953600877,-0.4784704878067327,0.33608656606312054,54,7,61,1,log_other_mut_burden,False,58,-0.14288755269804299,-0.17746241661256343,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11420706563673023,0.14535664260412529,0.4352399400455371,-0.40516999857405805,0.1767558673005976,54,7,61,1,log_other_mut_burden,False,58,-0.08002087551418569,-0.25927076038392055,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04426974057925041,0.1064770686045919,0.6791142131750143,-0.25740675046559375,0.16886726930709295,54,7,61,1,log_other_mut_burden,False,58,-0.07151960834950867,-0.04453782595540586,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10044265323660477,0.15972627587246563,0.5319211499913115,-0.42016953232792453,0.21928422585471496,54,7,61,1,log_other_mut_burden,False,58,0.07041854068194872,0.1231005223012425,0.9463401736865253,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043480806918737916,0.14281813780980596,0.7618757229869417,-0.3293623704256902,0.24240075658821442,54,7,61,1,log_other_mut_burden,False,58,0.01731405431158284,0.09000373900160243,0.9681057644104086,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06965340091204208,0.12060408053719798,0.5658116505253876,-0.3110686975826114,0.17176189575852724,54,7,61,1,log_other_mut_burden,False,58,0.03201343010606295,0.08974732340572654,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16204493313048618,0.15266856824074732,0.2929005087796838,-0.4676442754574101,0.14355440919643775,54,7,61,1,log_other_mut_burden,False,58,-0.11027400619912399,-0.04765579013907043,0.8803348634474737,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04984686640836519,0.22355160486446018,0.824336832209683,-0.49733402247428227,0.3976402896575518,54,7,61,1,log_other_mut_burden,False,58,-0.0027137628094999863,0.0932632816887453,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05647858856067384,0.12519622075484696,0.6535848507620672,-0.3070860525945576,0.19412887547320995,54,7,61,1,log_other_mut_burden,False,58,-0.09256474378066469,-0.052514236173289416,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03209483430662678,0.2013631874309157,0.8739171028186863,-0.3709773786370513,0.4351670472503049,54,7,61,1,log_other_mut_burden,False,58,-0.06429830567009556,0.12316248384098627,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0011384764071899224,0.12872947826841596,0.9929739948751544,-0.25881852378197234,0.25654157096759245,54,7,61,1,log_other_mut_burden,False,58,-0.0381108193467833,0.1026876732767396,0.999521629637202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10178504496038498,0.14089548620607872,0.4729420920996973,-0.38381800313623665,0.18024791321546668,54,7,61,1,log_other_mut_burden,False,58,0.1210812590621317,0.14008766388636637,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011400197603475042,0.12264348132271113,0.9262604799108602,-0.25689779848358557,0.23409740327663547,54,7,61,1,log_other_mut_burden,False,58,-0.11236921688973289,-0.029018021336309374,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07980180711035952,0.13767849083754505,0.5644127339350187,-0.3553952494106031,0.19579163518988407,54,7,61,1,log_other_mut_burden,False,58,0.2303804758054061,0.2344602646045668,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07848807480983631,0.1184739726941315,0.5102799604398492,-0.31563949736782454,0.15866334774815194,54,7,61,1,log_other_mut_burden,False,58,-0.05645092456750643,-0.016155754623552867,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006419699543836458,0.123572885956672,0.9587464783752404,-0.25377770592959203,0.24093830684191914,54,7,61,1,log_other_mut_burden,False,58,0.1140563079454255,0.21546283038916042,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04682911420051389,0.13288723854519388,0.7258175996978439,-0.31283182301620716,0.21917359461517938,54,7,61,1,log_other_mut_burden,False,58,-0.046314966220100916,-0.005099777425187413,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15663234800820347,0.1913356950141873,0.4163507502506101,-0.5396323540591825,0.22636765804277564,54,7,61,1,log_other_mut_burden,False,58,-0.13922353878075994,-0.06908149790921465,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09293425592254301,0.20334377415092506,0.6493565175139693,-0.4999710439325297,0.3141025320874437,54,7,61,1,log_other_mut_burden,False,58,-0.06762857862027881,0.021882803572504796,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11436366526996404,0.11890040335137247,0.34012083011892835,-0.3523686815303271,0.12364135099039901,54,7,61,1,log_other_mut_burden,False,58,-0.004476262121890241,-0.0069782865087853795,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09668075909780895,0.15277146511222767,0.5293217295120725,-0.4024860718914389,0.20912455369582106,54,7,61,1,log_other_mut_burden,False,58,-0.12049573819985057,-0.07749792741028357,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12006321583013672,0.18177279195473373,0.5115398694456964,-0.24379455996754817,0.48392099162782165,54,7,61,1,log_other_mut_burden,False,58,0.290872045606867,0.3529213663274069,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13061985143629276,0.12856841578157666,0.3138697752870611,-0.387977497215129,0.12673779434254348,54,7,61,1,log_other_mut_burden,False,58,0.004651247629367223,-0.022603115903761812,0.901410374901842,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1448461835108607,0.17498778160726813,0.4112049158545569,-0.205429918444196,0.4951222854659174,54,7,61,1,log_other_mut_burden,False,58,0.46680199409504797,0.4819410092869531,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040066031574381746,0.11179096031868614,0.7213442116402997,-0.26383995141368205,0.18370788826491855,54,7,61,1,log_other_mut_burden,False,58,-0.06572914466764677,-0.030206674354382908,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025307550107099067,0.10333780836493554,0.8073973600533932,-0.23216064788444032,0.1815455476702422,54,7,61,1,log_other_mut_burden,False,58,0.014098660922649522,0.06953554400282404,0.9744449538485335,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05761391548957275,0.10335701492352285,0.5793812699894381,-0.26450545937104847,0.14927762839190298,54,7,61,1,log_other_mut_burden,False,58,-0.06795369542396397,0.007816296691606153,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056646065193473094,0.1189901330975872,0.6358222760561991,-0.29483069505568205,0.18153856466873589,54,7,61,1,log_other_mut_burden,False,58,-0.010330879049690826,-0.004957319164293277,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06591273790141908,0.1106511911608047,0.5537062620853654,-0.2874051618894986,0.15557968608666045,54,7,61,1,log_other_mut_burden,False,58,-0.008854923493717514,0.00426555576850434,0.9486985340888475,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03919468276164328,0.11145628815332224,0.7263679009657246,-0.26229868347607793,0.18390931795279136,54,7,61,1,log_other_mut_burden,False,58,-0.011920167387804213,0.03675706244052089,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0760139923507934,0.0951020422663656,0.4273842488252072,-0.2663814131332966,0.11435342843170981,54,7,61,1,log_other_mut_burden,False,58,0.04947483354456029,0.037573285232218916,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09366311667111789,0.09605227887112694,0.33354715245406386,-0.2859326426794467,0.09860640933721092,54,7,61,1,log_other_mut_burden,False,58,-0.027989857403247196,-0.04124252430647696,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04013020722594185,0.0939844667226714,0.6709692181065199,-0.22826055750277927,0.14800014305089557,54,7,61,1,log_other_mut_burden,False,58,-0.05047835772732388,0.032218345778548985,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07757865231025636,0.09691181008335874,0.42668359760748575,-0.2715687169742781,0.11641141235376538,54,7,61,1,log_other_mut_burden,False,58,-0.020736905820930795,-0.05449933777659842,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03216448999958352,0.08611751605611183,0.7101415563133172,-0.20454742758026062,0.14021844758109359,54,7,61,1,log_other_mut_burden,False,58,0.03570278651957764,-0.01102314421028843,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07865660954229545,0.12198938533676906,0.5216104538978901,-0.32284489505103653,0.16553167596644563,54,7,61,1,log_other_mut_burden,False,58,-0.02230123765447694,0.008666555282972737,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045912989657302256,0.1065213418802519,0.6680504570817547,-0.2591386221336146,0.16731264281901012,54,7,61,1,log_other_mut_burden,False,58,-0.269215174823168,-0.29065404192350347,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1081587380301106,0.11139139278468074,0.3355905714500572,-0.33113283655049547,0.11481536049027428,54,7,61,1,log_other_mut_burden,False,58,0.2911466248398007,0.23788333480274584,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17274669396015166,0.2455481357147838,0.4845498362761661,-0.6642646904197016,0.3187713024993982,54,7,61,1,log_other_mut_burden,False,58,-0.15174406440952803,-0.12367137148312084,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014619304539558115,0.15447034014045613,0.9249257973843024,-0.3238252851805708,0.29458667610145456,54,7,61,1,log_other_mut_burden,False,58,0.2479776631390223,0.28667583359641075,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1571807333968363,0.15406370002971395,0.3118552018517596,-0.4655727354184216,0.15121126862474898,54,7,61,1,log_other_mut_burden,False,58,0.07425299659782414,0.03642899314603102,0.8990379896110621,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0997979349859922,0.1543685602415251,0.5205113450429832,-0.20920431105179566,0.4088001810237801,54,7,61,1,log_other_mut_burden,False,58,-0.05188724410014737,0.2207383961075837,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1559420637694633,0.16092469713862084,0.3365502078636595,-0.4780678436626174,0.16618371612369082,54,7,61,1,log_other_mut_burden,False,58,-0.07596206436385698,-0.14376303454425007,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05778646651446129,0.19734428040476973,0.77070436062991,-0.3372410299678263,0.45281396299674886,54,7,61,1,log_other_mut_burden,False,58,0.09765454007473183,0.3429186955162953,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0921378391186007,0.14207789179881655,0.5192195363995038,-0.37653763924278677,0.1922619610055854,54,7,61,1,log_other_mut_burden,False,58,-0.0709857096887222,-0.04105411840881912,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03899963522065597,0.09905456661160146,0.69523245485417,-0.15927962265021556,0.2372788930915275,54,7,61,1,log_other_mut_burden,False,58,-0.04900019426070754,0.11225158434796724,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0732441465961862,0.09615327093934498,0.4492994454179545,-0.26571583019322703,0.11922753700085464,54,7,61,1,log_other_mut_burden,False,58,0.028781576724320888,-0.03209196236729351,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028088572647969524,0.12569797168842362,0.8239620702639152,-0.2797004002982799,0.22352325500234085,54,7,61,1,log_other_mut_burden,False,58,-0.11901117459392069,-0.04635742563565289,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06388454144515478,0.15107239045113424,0.6739511908742457,-0.3662887867828059,0.23851970389249638,54,7,61,1,log_other_mut_burden,False,58,-0.08619866742155465,-0.03110885785086425,0.9604420702583071,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05416756890175084,0.19400015343497867,0.781073791426838,-0.442501067959406,0.33416593015590434,54,7,61,1,log_other_mut_burden,False,58,-0.0041872966798962635,0.14836015808421163,0.971527114099096,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12675510405283502,0.14600655978650792,0.38889206819413413,-0.4190189875773846,0.16550877947171455,54,7,61,1,log_other_mut_burden,False,58,-0.009278997949748307,-0.04877947063638539,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05969814867201386,0.12383271187486901,0.6315583908109261,-0.3075762531410585,0.18817995579703078,54,7,61,1,log_other_mut_burden,False,58,0.003988135723861514,0.05850253409244642,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10844244445121731,0.13076076492807398,0.4103238801192002,-0.37018855384794813,0.1533036649455135,54,7,61,1,log_other_mut_burden,False,58,-0.037172089249163764,0.015412931921354987,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09455104076651123,0.1640032770802354,0.5664950519454217,-0.42283926795513405,0.2337371864221116,54,7,61,1,log_other_mut_burden,False,58,0.1692859758157401,0.12610757413281962,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025590866622868275,0.1260538309080662,0.8398335471059217,-0.27791502389503153,0.22673329064929496,54,7,61,1,log_other_mut_burden,False,58,-0.028335576848531496,0.04518177098981764,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10863746387297883,0.12515159656574357,0.38894617435464385,-0.35915560288731857,0.14188067514136088,54,7,61,1,log_other_mut_burden,False,58,0.029455643413579074,-0.010739789018329568,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08222512304372852,0.09041615864409278,0.3668987911175752,-0.26321272865085843,0.09876248256340138,54,7,61,1,log_other_mut_burden,False,58,0.08427316580557766,0.08111286685251831,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02578564502334606,0.09524250427174158,0.7875546741300847,-0.2164342310578685,0.16486294101117635,54,7,61,1,log_other_mut_burden,False,58,0.08514245211462373,0.10858926701327268,0.9725589613012776,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11047223102740748,0.10421711941844274,0.2935299429293996,-0.31908546111455627,0.09814099905974129,54,7,61,1,log_other_mut_burden,False,58,0.005735104869600451,-0.041697760198512124,0.8803348634474737,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05818490615410054,0.2127454013066318,0.7854439404954211,-0.4840410956210801,0.367671283312879,54,7,61,1,log_other_mut_burden,False,58,-0.09706960547560597,0.04787469915620484,0.9722536916492144,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13468665439862343,0.0995653718048807,0.18138694340154818,-0.3339883999558742,0.06461509115862735,54,7,61,1,log_other_mut_burden,False,58,0.010766174838298606,-0.052756683849889977,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029221221199209082,0.1448298554912155,0.8408084547610958,-0.319129675162203,0.26068723276378486,54,7,61,1,log_other_mut_burden,False,58,-0.053246944687500956,0.07509971320176152,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10899626168963975,0.1098588608081097,0.3252465038755894,-0.32890266415751074,0.11091014077823125,54,7,61,1,log_other_mut_burden,False,58,-0.009269804730769682,-0.05244081966885909,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021988756745833414,0.1009315452729355,0.8283043187995857,-0.22402519562046483,0.180047682128798,54,7,61,1,log_other_mut_burden,False,58,0.034486889520176554,0.12341276470487332,0.9817239773275311,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047686391843463925,0.117695541287455,0.6868450997693947,-0.2832796146445001,0.1879068309575722,54,7,61,1,log_other_mut_burden,False,58,-0.06319360382333067,-0.042238636216864515,0.9631430579652833,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05497812402303645,0.11396342306626248,0.6313240269893339,-0.2831007005278145,0.1731444524817416,54,7,61,1,log_other_mut_burden,False,58,0.007135587539439309,0.023200588867990615,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06361436314781153,0.11336314949075793,0.5768532236403769,-0.2905353615412318,0.16330663524560868,54,7,61,1,log_other_mut_burden,False,58,0.010846705631764231,0.06817208365710334,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05362542998198498,0.06780326874547446,0.4322261156516738,-0.1893484185119994,0.08209755854802943,54,7,61,1,log_other_mut_burden,False,58,-0.09194200907460787,-0.13869784071983468,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06214683421353641,0.11794597730969916,0.6002661277267658,-0.29824135917895844,0.17394769075188565,54,7,61,1,log_other_mut_burden,False,58,-0.000251898068870366,0.04312721549039857,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014875984246664921,0.06558971226372262,0.8213739359481637,-0.14616805806501368,0.11641608957168384,54,7,61,1,log_other_mut_burden,False,58,-0.047582918749624524,-0.044762742243197914,0.9793038292216457,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09507437612640866,0.11005221683227982,0.3912001972410799,-0.31536782272852576,0.12521907047570846,54,7,61,1,log_other_mut_burden,False,58,-0.03244745957923851,0.024123862400346346,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06241441799878359,0.10838971652090157,0.5669554776566179,-0.27938000866021795,0.15455117266265078,54,7,61,1,log_other_mut_burden,False,58,0.1151070812195045,0.14858293494296101,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10655026795948667,0.13289224428589694,0.42595336745607004,-0.3725629968538664,0.15946246093489302,54,7,61,1,log_other_mut_burden,False,58,-0.09278021509560937,-0.037329502111871964,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08362198191851396,0.15131282663916049,0.5826315447097564,-0.38650751257755844,0.21926354874053056,54,7,61,1,log_other_mut_burden,False,58,0.03744379717012095,0.14616062677667813,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009857680933870211,0.13888916472925492,0.9436616904793231,-0.2878745503307476,0.2681591884630071,54,7,61,1,log_other_mut_burden,False,58,0.025245251501383178,0.16425457038724062,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1250131961325719,0.1249941107368109,0.3213911279773365,-0.375216093009632,0.1251897007444882,54,7,61,1,log_other_mut_burden,False,58,-0.030518121151489115,-0.11246987174394106,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1282759393792554,0.14030096697744557,0.3643492237248336,-0.40911883802049154,0.15256695926198072,54,7,61,1,log_other_mut_burden,False,58,-0.08644520291667422,-0.03208270821111457,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08928613451522696,0.12544506932098048,0.4794697355849048,-0.34039172307484467,0.16181945404439077,54,7,61,1,log_other_mut_burden,False,58,-0.0064567980267377645,-0.00418380552578747,0.9384017168502401,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08499764246223082,0.15840965604220592,0.5936178963780939,-0.40208902061934737,0.23209373569488576,54,7,61,1,log_other_mut_burden,False,58,-0.00857343050369527,0.062069293996085705,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0132888234039868,0.12670592389238525,0.9168334767859585,-0.2669182866041499,0.24034063979617631,54,7,61,1,log_other_mut_burden,False,58,0.09083666801911511,0.16781939556086972,0.989733344444655,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026561688500250497,0.16110915436600262,0.869621419211343,-0.34905669965053165,0.2959333226500307,54,7,61,1,log_other_mut_burden,False,58,-0.0010487956443671178,0.13720135617369636,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029887802691698297,0.10370528369428356,0.7742215027173435,-0.23747648226078752,0.17770087687739092,54,7,61,1,log_other_mut_burden,False,58,0.22135514019075392,0.20529620692224473,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09767056431684189,0.11677635635580237,0.4063683590572642,-0.33142383856902613,0.13608270993534233,54,7,61,1,log_other_mut_burden,False,58,0.04312436661419446,0.012400400517456287,0.9239663408808872,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045759708565275316,0.1576527504931397,0.772655407620034,-0.3613359756509795,0.26981655852042885,54,7,61,1,log_other_mut_burden,False,58,0.028132248164703527,0.12549113419884697,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07215979479650927,0.13742538114671535,0.6015266926107026,-0.34724658300321243,0.20292699341019385,54,7,61,1,log_other_mut_burden,False,58,0.014921071139362037,0.09368099818676967,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007263006390116354,0.1054048973333976,0.9453016336699083,-0.21825383229691184,0.20372781951667915,54,7,61,1,log_other_mut_burden,False,58,0.07801973139753977,0.09234711002435494,0.993077588787628,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012215193013292583,0.10904454160721026,0.9111941673714412,-0.20606117247246283,0.23049155849904798,54,7,61,1,log_other_mut_burden,False,58,0.0668377393059169,0.11752504405235145,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09487085290412756,0.08588166802766477,0.273864544722739,-0.266781689362661,0.07703998355440589,54,7,61,1,log_other_mut_burden,False,58,-0.027631283660935074,-0.03662672986871653,0.870270919138952,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032947418694448505,0.08384521216141984,0.6957931196335682,-0.13488700845093232,0.20078184583982933,54,7,61,1,log_other_mut_burden,False,58,-0.012589529686032898,0.048278936676820115,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1674432554043209,0.13814075943063217,0.23038093736110946,-0.44396202882971814,0.10907551802107637,54,7,61,1,log_other_mut_burden,False,58,-0.12764435869119262,-0.24078845384500316,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019557415421416792,0.08132840242678605,0.810810321297418,-0.14323906967388064,0.1823539005167142,54,7,61,1,log_other_mut_burden,False,58,0.0033538113559130026,0.08267671307744218,0.9751836864331673,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13809580709574332,0.1612221773708691,0.3952155646759399,-0.46081705837097636,0.18462544417948973,54,7,61,1,log_other_mut_burden,False,58,-0.04523294636316641,-0.1439064642146368,0.920957044807631,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006499861495866165,0.0844666725677745,0.938926741512919,-0.16257855381061878,0.17557827680235114,54,7,61,1,log_other_mut_burden,False,58,0.03025076624403081,0.039098672536931035,0.992787535469879,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15345037172541323,0.15694906345561618,0.33227925216059884,-0.46761805616474017,0.16071731271391373,54,7,61,1,log_other_mut_burden,False,58,-0.08444619248829648,-0.1788033036695338,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0840343121938206,0.07697346100274571,0.27946571210560994,-0.23811343489818815,0.07004481051054695,54,7,61,1,log_other_mut_burden,False,58,-0.06778437841723402,-0.11134520574390547,0.875118556630215,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03328638714412844,0.06871664189635447,0.6299258025678678,-0.1708376906798082,0.10426491639155133,54,7,61,1,log_other_mut_burden,False,58,-0.07348572110165409,-0.10010761252304291,0.96007126858481,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052057271449406174,0.09684257688817023,0.5929475695082513,-0.24590875081613583,0.1417942079173235,54,7,61,1,log_other_mut_burden,False,58,0.04091982638492415,0.04877244261196394,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09751034767043266,0.10616994009273764,0.3621941294500499,-0.3100325730447178,0.1150118777038525,54,7,61,1,log_other_mut_burden,False,58,-0.012265780374209294,0.016844306617350622,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1154705326539964,0.17068050447420882,0.501393191537977,-0.4571246826627493,0.22618361735475653,54,7,61,1,log_other_mut_burden,False,58,0.03938384606319314,0.12930707300386837,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01680438391958706,0.12415454319339765,0.8928033818145766,-0.265326703765876,0.2317179359267019,54,7,61,1,log_other_mut_burden,False,58,0.03059116648492602,0.16103625773326963,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0016600952252916806,0.09253269656265233,0.9857477878406629,-0.18356422133927522,0.18688441178985857,54,7,61,1,log_other_mut_burden,False,58,0.02284907596760439,0.06885391562898287,0.998906982267571,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09924155986048892,0.10139942797767616,0.33178359378272615,-0.30221456772572886,0.10373144800475102,54,7,61,1,log_other_mut_burden,False,58,0.027507567203786346,0.06329624043695958,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07519240626787545,0.14793653054954656,0.6131884797066596,-0.3713195460126886,0.2209347334769377,54,7,61,1,log_other_mut_burden,False,58,0.03660423498855091,0.06064042339628685,0.9552990821084932,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08799313631309033,0.10629462411034282,0.41116404614261937,-0.3007649438654093,0.12477867123922862,54,7,61,1,log_other_mut_burden,False,58,-0.012078893847406092,0.048706494771574065,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04301759883171174,0.134356053881044,0.7499854480055062,-0.3119604609861569,0.22592526332273338,54,7,61,1,log_other_mut_burden,False,58,-0.05863884535628358,0.0013018272818809326,0.9644346245002389,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052645079238610046,0.12595072264805957,0.6775040839600238,-0.3047628429039582,0.1994726844267381,54,7,61,1,log_other_mut_burden,False,58,-0.023402327144704846,0.055076975032869936,0.9619695749374265,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060753244117080774,0.13051032624626865,0.6433129255958516,-0.32199804602573556,0.20049155779157402,54,7,61,1,log_other_mut_burden,False,58,-0.0218684438292345,0.013576850785970897,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01758629974751124,0.1766204409381226,0.9210281653224294,-0.3711305244307922,0.3359579249357697,54,7,61,1,log_other_mut_burden,False,58,0.01702912837877615,0.1780163005844572,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08077469255142578,0.15504196410832474,0.6043600205325688,-0.3911249028832775,0.22957551778042595,54,7,61,1,log_other_mut_burden,False,58,0.14175082398770247,0.22915636107123544,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0073963123775979385,0.15006224852445865,0.9608588889432865,-0.2929859142039586,0.3077785389591544,54,7,61,1,log_other_mut_burden,False,58,-0.1295076812291129,-0.0011895271060909454,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.160463033491388,0.19037450755446217,0.4027576514731265,-0.5415390137986942,0.22061294681591817,54,7,61,1,log_other_mut_burden,False,58,0.07301678501366869,0.06520357881558815,0.923447045283853,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02123561405962609,0.13034831700956925,0.8711521603564594,-0.2821561192465867,0.2396848911273345,54,7,61,1,log_other_mut_burden,False,58,0.043136508149598865,0.1313353095016018,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038759109880918206,0.11811436606564067,0.7439807418348312,-0.2751907015632418,0.19767248180140543,54,7,61,1,log_other_mut_burden,False,58,0.009963061091456173,0.06500896157585877,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046625669145496415,0.09550544855125084,0.6272495021537883,-0.23780059534166847,0.14454925705067567,54,7,61,1,log_other_mut_burden,False,58,-0.09957794199827115,-0.08719364676143086,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01612003546742616,0.07794429718009557,0.8368788366347197,-0.13990242698738334,0.17214249792223565,54,7,61,1,log_other_mut_burden,False,58,-0.08391625162254437,-0.005591263257977006,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03933737649774317,0.10295817049770696,0.7038047486101625,-0.24543054651860935,0.16675579352312303,54,7,61,1,log_other_mut_burden,False,58,-0.038202417581803955,0.020811790992731855,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05664292219626618,0.21110478503645702,0.7894076444711295,-0.36592921699793135,0.47921506139046377,54,7,61,1,log_other_mut_burden,False,58,0.0015971040562024693,0.25779914806101745,0.9727286373504853,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06600601797946333,0.08158675818776544,0.421805138428777,-0.22931965831864287,0.0973076223597162,54,7,61,1,log_other_mut_burden,False,58,-0.10500885805359007,-0.14868492684403836,0.9282753503874777,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054421003698807875,0.08330178575961016,0.5161448657082324,-0.22116764471434014,0.1123256373167244,54,7,61,1,log_other_mut_burden,False,58,0.04820583383137758,0.04378790146905924,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057428729225346455,0.14351502270819555,0.6905099677892848,-0.344705259417842,0.2298478009671491,54,7,61,1,log_other_mut_burden,False,58,0.05540507618010574,0.12446661843116127,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04525403538109131,0.08535278826867178,0.5979974541761841,-0.21610620397903796,0.12559813321685537,54,7,61,1,log_other_mut_burden,False,58,-0.03382832937182029,0.0012911019187896247,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.063769089962094,0.13239058753246927,0.6318501381663209,-0.328777643762098,0.20123946383790997,54,7,61,1,log_other_mut_burden,False,58,0.11009486247880812,0.15067524163064291,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056118020113621256,0.07304253342656025,0.44543050469003875,-0.20232853635982972,0.0900924961325872,54,7,61,1,log_other_mut_burden,False,58,-0.004665123627417255,-0.014040763840200862,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08112377969916867,0.10128071123813881,0.4264125742585263,-0.283859150191216,0.12161159079287864,54,7,61,1,log_other_mut_burden,False,58,0.034525722977811736,0.04979213443976192,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08012828751217853,0.19804167521776947,0.6872575221203976,-0.47655177138499993,0.31629519636064285,54,7,61,1,log_other_mut_burden,False,58,-0.0023734506817452744,0.11858696359495889,0.9631797688191589,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08719471577253826,0.15057811492675505,0.5647866742879897,-0.3886095611510545,0.214220129605978,54,7,61,1,log_other_mut_burden,False,58,-0.03141411803461306,0.03784157336117883,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09006509745142992,0.09162422713405166,0.32969839660482303,-0.27347091487695546,0.09334071997409561,54,7,61,1,log_other_mut_burden,False,58,0.02911511806748116,-0.04016720661222033,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11669947106656522,0.2264710627167446,0.6083052173701087,-0.5700305569596251,0.3366316148264946,54,7,61,1,log_other_mut_burden,False,58,-0.08440383415931405,0.008983551943399868,0.9537283854402375,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10130231780139672,0.1295881061356258,0.43755553672348435,-0.36070109559034735,0.15809645998755395,54,7,61,1,log_other_mut_burden,False,58,0.019092187941474537,0.057792675822158586,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12691143516464914,0.169799202375546,0.4578292668033497,-0.46680146735369477,0.21297859702439648,54,7,61,1,log_other_mut_burden,False,58,-0.050095006427149986,-0.08571818413072174,0.9362244046839282,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04580333239807751,0.11387068982927695,0.6889860806742192,-0.2737402831610202,0.18213361836486522,54,7,61,1,log_other_mut_burden,False,58,0.10567650743143177,0.2188366508535106,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12929765036843396,0.1638156157265459,0.43315864774375024,-0.4572102325442782,0.19861493180741022,54,7,61,1,log_other_mut_burden,False,58,-0.26954280395796787,-0.25563577118295283,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10796175285264517,0.14887215397898118,0.4712465680732556,-0.4059617463747335,0.19003824066944316,54,7,61,1,log_other_mut_burden,False,58,-0.10248375053406569,-0.059793985354185016,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.051148824311914615,0.17718713384438112,0.7738622067889961,-0.40582740809379436,0.3035297594699651,54,7,61,1,log_other_mut_burden,False,58,0.04299073954994622,0.1954476213060387,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0028561625099672184,0.1924072724527107,0.9882072958894329,-0.3880011638552542,0.3822888388353197,54,7,61,1,log_other_mut_burden,False,58,-0.03472845950142826,0.14654270007378306,0.9990191441902606,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11017544035179869,0.12428705089113525,0.37903084639311935,-0.35896300317343277,0.13861212246983542,54,7,61,1,log_other_mut_burden,False,58,-0.1115258979691055,-0.0674484734272872,0.9183506089424412,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2955837833798991,0.09422469975168697,0.002680906200464018,-0.48419501231118617,-0.10697255444861203,54,7,61,1,log_other_mut_burden,False,58,0.8038415967027416,0.5686300473639944,0.07911164839882295,0.7560459172479591 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013487601173383892,0.11969883313126073,0.9106737711309185,-0.2530908482840115,0.2261156459372437,54,7,61,1,log_other_mut_burden,False,58,0.09021992344552937,0.22877097845863198,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015170254647106042,0.10253527504751417,0.8828941492828267,-0.19007639815714378,0.22041690745135584,54,7,61,1,log_other_mut_burden,False,58,0.09289751776997278,0.2359434291769185,0.9870713197539774,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14532184187416736,0.1218904461206606,0.2380249614911257,-0.38931207902415654,0.0986683952758218,54,7,61,1,log_other_mut_burden,False,58,-0.11233330905565814,-0.12725053889209664,0.8459452857747916,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0228419971266273,0.10862575123898827,0.8341848730561565,-0.2402800626101211,0.19459606835686652,54,7,61,1,log_other_mut_burden,False,58,0.023861571568739273,0.12345799743496766,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15279907564687778,0.11989989150281506,0.20760806542963708,-0.39280478481517944,0.08720663352142391,54,7,61,1,log_other_mut_burden,False,58,-0.15890246418564846,-0.16331586309308527,0.8210381131305959,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15498455803381536,0.1217074943984571,0.20794963483136805,-0.3986085775227153,0.08863946145508456,54,7,61,1,log_other_mut_burden,False,58,-0.11572582398266308,-0.11643298088107404,0.8210381131305959,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09890207554128931,0.11054314108272922,0.3746496120051911,-0.3201782137989219,0.12237406271634328,54,7,61,1,log_other_mut_burden,False,58,0.017895631219311536,0.015949255244965727,0.9159127256227925,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06094378100734774,0.07127953501116713,0.39607094311904,-0.20362527250094345,0.08173771048624798,54,7,61,1,log_other_mut_burden,False,58,-0.05138796162088282,-0.09879576898427489,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07483410874355428,0.15142081733511978,0.6230225472194024,-0.37793580626682555,0.22826758877971698,54,7,61,1,log_other_mut_burden,False,58,0.03404513084998191,0.06284562469908964,0.9584620018167673,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10742471535545763,0.12201008975121577,0.3822452503476854,-0.35165444525259565,0.13680501454168043,54,7,61,1,log_other_mut_burden,False,58,-0.06463668642696392,-0.0866673614429374,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09751530863292453,0.2252668643196125,0.666701709249842,-0.5484359295400654,0.35340531227421634,54,7,61,1,log_other_mut_burden,False,58,-0.025254735232882842,0.12108770459576143,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12061545617049718,0.14869551476083306,0.4205916129041415,-0.4182618678812327,0.17703095554023834,54,7,61,1,log_other_mut_burden,False,58,-0.07477469041230506,-0.07319773818140338,0.9279200175745067,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07109778714084011,0.14969146937337735,0.636597616443761,-0.37073781861292066,0.2285422443312404,54,7,61,1,log_other_mut_burden,False,58,-0.07089613800392557,0.001060224657190943,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06318965108307087,0.23133508635037386,0.7857066217375352,-0.526257138126862,0.39987783596072035,54,7,61,1,log_other_mut_burden,False,58,-0.010007474475630773,0.08762850632792443,0.9722536916492144,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03604777123026407,0.12346014840114874,0.7713445215120716,-0.283180108880009,0.21108456641948084,54,7,61,1,log_other_mut_burden,False,58,0.06055064010977249,0.12274184045190929,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01920643119711747,0.16827802730100944,0.9095248734421535,-0.3560515006430173,0.3176386382487824,54,7,61,1,log_other_mut_burden,False,58,-0.22684997488966369,-0.21887391300871895,0.9890879681893895,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18284364334221065,0.149226584613928,0.2254240617209186,-0.4815531068631887,0.1158658201787674,54,7,61,1,log_other_mut_burden,False,58,-0.10699044284247347,-0.0882650438466481,0.8397072744911553,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011082421274350687,0.07266519278815903,0.8793112872138187,-0.1565376081671929,0.1343727656184915,54,7,61,1,log_other_mut_burden,False,58,-0.031830721557384145,-0.009383747272041406,0.9864402192918322,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07113217135079214,0.09776363523876323,0.46978958383820835,-0.2668273493218218,0.1245630066202375,54,7,61,1,log_other_mut_burden,False,58,0.11263841042925941,0.08601106652298089,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09956402342225121,0.08069349699197896,0.22223370766439862,-0.26108960720791646,0.06196156036341405,54,7,61,1,log_other_mut_burden,False,58,-0.08687587880847776,-0.1728124511769176,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0009172733022490207,0.14518968113064015,0.9949808721522948,-0.289711449934425,0.291545996538923,54,7,61,1,log_other_mut_burden,False,58,0.1342267127015296,0.14535235701566754,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06542806456237786,0.09317783643222181,0.4853724129602247,-0.25194376888358117,0.12108763975882546,54,7,61,1,log_other_mut_burden,False,58,-0.20016605332438023,-0.27613473793342713,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07096825806557473,0.09373412991024041,0.45204111031957706,-0.25859750476804383,0.11666098863689438,54,7,61,1,log_other_mut_burden,False,58,0.07795872023449943,0.051199040675774236,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09745460387841576,0.06767562878470683,0.15523645544646741,-0.232922093267286,0.03801288551045448,54,7,61,1,log_other_mut_burden,False,58,-0.04651165845279218,-0.11467997059383953,0.7740370498329512,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03152302399268445,0.08848278851324,0.7229373326431605,-0.20864056880556217,0.14559452082019328,54,7,61,1,log_other_mut_burden,False,58,-0.04441305161131574,-0.004587221534169739,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13593609334922283,0.08874260348173116,0.13100799223948917,-0.31357371432717196,0.04170152762872631,54,7,61,1,log_other_mut_burden,False,58,-0.011463764972100221,-0.11280964905299558,0.7360778123788349,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00047872220456672245,0.09725318104732701,0.9960893750440931,-0.19419467068660984,0.19515211509574326,54,7,61,1,log_other_mut_burden,False,58,-0.01536152428196396,0.04521632169612387,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12498210687079554,0.10000712544881205,0.21641694519318314,-0.3251681184207886,0.07520390467919748,54,7,61,1,log_other_mut_burden,False,58,0.06975786744873892,-0.04853891997704327,0.8295752524063543,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07292397259077756,0.10500787046014504,0.49016508965941274,-0.2831200628637079,0.13727211768215275,54,7,61,1,log_other_mut_burden,False,58,0.1261287918817924,0.08909763784696434,0.9418332435783486,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05398336782126649,0.07296395577497573,0.4623671408778871,-0.20003659380843514,0.09206985816590217,54,7,61,1,log_other_mut_burden,False,58,-0.1628196528099443,-0.21063215344253913,0.9372011503139762,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05862746488885523,0.11058568775433679,0.5980289112359616,-0.27998876956293683,0.1627338397852264,54,7,61,1,log_other_mut_burden,False,58,0.06389931758505668,0.02427047058088935,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05807740883168201,0.09446575945602201,0.5410923566551225,-0.24717117118785942,0.13101635352449537,54,7,61,1,log_other_mut_burden,False,58,0.004067160458057041,-0.03181783470341491,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0255068977058481,0.10335261002692335,0.8059383986793615,-0.23238962422878476,0.18137582881708855,54,7,61,1,log_other_mut_burden,False,58,0.005441255124309352,0.023116783495170008,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1420836270966737,0.10850245152146369,0.19552980974736064,-0.35927488137980834,0.075107627186461,54,7,61,1,log_other_mut_burden,False,58,0.03223561093783284,-0.08122233574435514,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07619373065237905,0.11042172205912441,0.4929304657323129,-0.29722682232755404,0.14483936102279593,54,7,61,1,log_other_mut_burden,False,58,0.0021696153928577534,-0.011281918395517994,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07882763909145714,0.07071487574949908,0.2695661041474157,-0.2203788422683874,0.0627235640854731,54,7,61,1,log_other_mut_burden,False,58,-0.06714833395383286,-0.08849946495785041,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030571167184387262,0.10593944458645814,0.7739376867090737,-0.24263200567373586,0.18148967130496133,54,7,61,1,log_other_mut_burden,False,58,0.3555150246385562,0.5390976036618587,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11474598359198844,0.17285563727732142,0.509432248831823,-0.4607541349630697,0.2312621677790928,54,7,61,1,log_other_mut_burden,False,58,-0.13002042686147758,-0.34411881408358125,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13856742303781538,0.1681259912544975,0.41145442529828213,-0.19428232197835205,0.4714171680539828,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13553543610826474,0.24184778914237318,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13300594999242835,0.1495693516462115,0.3756282052017056,-0.16310603237391033,0.42911793235876705,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1696219442757489,0.21492721845129117,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10593426175300392,0.0740882408759979,0.15534020454829003,-0.04074295275895877,0.2526114762649666,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.25299795875963366,0.03600168921388743,0.7740681379185977,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1153484869536226,0.17760053289064576,0.5172573884250632,-0.23625861225987005,0.46695558616711524,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.08967871326557583,0.42752437465460524,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1315776193963058,0.10142225798736823,0.19698748566725535,-0.0692144916756722,0.3323697304682838,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.148408176847641,0.13042479260409462,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0929837646505249,0.09991940969623143,0.35391985818250005,-0.10483306183416012,0.2908005911352099,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.34524014582844315,-0.03847420446671863,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04467586495094215,0.12415893098538161,0.7196029943782414,-0.20112948740179046,0.29048121730367477,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09218504055972898,0.14750039266179643,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13222704671894284,0.08528776502449371,0.12366592101519656,-0.036622579859197174,0.3010766732970829,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3822589741976117,0.020074069681544657,0.7255706347976272,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055099922255080924,0.0950968842510373,0.5633909023855541,-0.1331694431095858,0.24336928761974766,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07079146472372895,0.09162526361244228,0.9517337695544857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13570395284956602,0.1556412924679995,0.38498862791248345,-0.17242903792365297,0.44383694362278503,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.06524781827550226,0.3534979240061717,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11951228757514583,0.09995888722758348,0.23418494585542277,-0.07838269509554201,0.31740727024583365,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14100449692061362,0.23564639457632972,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060081761351988464,0.16254368908311126,0.7123009322363709,-0.26171634411407224,0.38187986681804914,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.10930442458084798,0.3093317292669472,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12313048643426035,0.11478313392244598,0.2855302800326751,-0.10411300264893465,0.35037397551745536,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09434925382512795,0.23308451616112416,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09858962697928707,0.09847236438294102,0.3187325575269964,-0.09636239163148351,0.29354164559005763,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16060143510696756,0.12409848851239542,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052075813639674555,0.19718522951892017,0.7921552888929992,-0.442455985536929,0.3383043582575799,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.18755442892562135,-0.14410200231111148,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029767921855040173,0.08017189499405879,0.7110625298586748,-0.128953490623303,0.18848933433338336,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.7385001340849425,-0.33675241370318465,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03296007138277337,0.07875380704715365,0.6763086141133012,-0.12295386196628172,0.18887400473182847,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0057076961786060735,0.0730271226936082,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11312783507951174,0.09847332499051284,0.2528973412322271,-0.08182608530731947,0.308081755466343,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16768134480570365,0.19452034458143205,0.8623277898201971,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051425895712827345,0.09847545788927223,0.6024716144100798,-0.14353224730967673,0.24638403873533143,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03558815459706033,0.1258838489094938,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09304999874516695,0.09880747225122997,0.3482070698285302,-0.10256545427976299,0.2886654517700969,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.15224116832209048,0.17979338059518013,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18138937715335846,0.13681765195855275,0.1874118250622049,-0.08947725226136505,0.45225600656808196,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10629231889028823,0.24821603586591165,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10408958500758801,0.15599221759195903,0.5058675571202182,-0.20473815460938877,0.4129173246245648,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19088419027729903,0.20156805342813575,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1391338558470099,0.08629024832534264,0.10948155809713675,-0.03170045084263906,0.3099681625366589,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2670693718011217,0.026823760002129816,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009082495973204487,0.16912114479399976,0.9572594968833676,-0.32573741795857014,0.3439024099049791,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.018720874052435492,0.26004284480492673,0.9957512552242196,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07767660097978274,0.1168682504025073,0.507538457048833,-0.15369492615118113,0.3090481281107466,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.15690358163008652,0.13858655043873247,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15205385900794746,0.08303584021295206,0.06953334804318799,-0.012337488432479699,0.3164452064483746,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.23745851690773506,0.14793894799809967,0.6098958196318522,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06868341948542488,0.0984077730614475,0.4865493547691908,-0.12614072356768236,0.2635075625385321,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.23278788732321734,0.051028335806953186,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14156874014907747,0.07302300133727015,0.05486806449562542,-0.0029995517257543902,0.28613703202390933,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.29901606124933533,0.12113615086858813,0.5490443949486614,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13167084795062572,0.10549916466173054,0.2144134198194408,-0.07719257521825512,0.34053427111950657,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.17324258470385726,0.15490723864038608,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13511246207597175,0.09090786097817155,0.13981209431422056,-0.044863626812902874,0.31508855096484634,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06803472330814508,0.20468319873774513,0.7565292465346168,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10226164277632567,0.1019537202949112,0.31785273675373843,-0.09958263811324829,0.3041059236658996,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06429936158143813,0.2362987433394192,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055649576962379,0.13149746180140454,0.6729014040207904,-0.20468433276973608,0.31598348669449405,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09418019988857129,0.11305169156056363,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04089945149490635,0.15248130228314793,0.7889820923655182,-0.26097750522056073,0.3427764082103735,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04728641074439388,0.17548182824828903,0.97265722149363,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07678195640206281,0.09332308201866302,0.4122662866975155,-0.10797569958114864,0.26153961238527423,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.043313390126318206,0.13324658398715022,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10233042082725155,0.13787256310497675,0.45939834176951877,-0.17062468344779522,0.3752855251022983,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.024810809478339656,0.24582966582820598,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11766497361003124,0.10225393762275178,0.25211914009227293,-0.08477366666606916,0.3201036138861316,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.24586191723012765,0.016306752315929242,0.8604134712177398,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20358201618492508,0.12096342928507928,0.09495274427944776,-0.03589699769861554,0.4430610300684657,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13676420185549318,0.22629819976926852,0.6729775750805861,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07015079741553013,0.07670458497578078,0.3622425761333993,-0.08170616033535305,0.2220077551664133,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.324219401378047,-0.05046700408778477,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04453204623674945,0.08239438297363504,0.5898634590655945,-0.11858936740609938,0.20765345987959827,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.22599257112827761,-0.007037797413309205,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08271037820417676,0.0666746961494695,0.21718818659681954,-0.049289769106703074,0.2147105255150566,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1369597437146825,0.08180616499527811,0.8308625663641223,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0639840514214169,0.08117322608054339,0.43209739042468764,-0.09671976005619017,0.22468786289902398,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.22205642852188376,0.0015635535925451016,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05507640512621755,0.08042163793917938,0.4947511258401194,-0.10413943938480963,0.21429224963724475,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.013735161024705692,0.15977890940542885,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12095191799750458,0.07502971703170838,0.10955564818353639,-0.027589196890769815,0.26949303288577897,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08550910275746876,0.09134827279546216,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11952487120941621,0.07956860659745278,0.1356607726338379,-0.038002172763003605,0.27705191518183603,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12382462390451715,0.17616224326606697,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08849877383778837,0.057309947221184446,0.12514809929298595,-0.024961382900178034,0.20195893057575476,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10347498466141547,0.07968218900002166,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06505621751546878,0.07723075958541119,0.4012475585341987,-0.08784244166029612,0.21795487669123367,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08520230054106252,0.08505034169058259,0.922683406617749,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09652092551585242,0.10621273782774526,0.36528809140431295,-0.11375520394898031,0.30679705498068516,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03657626150550463,0.1551858166876158,0.9138534098857347,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02709106475630975,0.06639035846295628,0.6839528250036431,-0.10434616110650467,0.15852829061912416,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.012107933709326705,0.05939902414649943,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08083639609903587,0.06049415815147592,0.18396927138372252,-0.038927746050804554,0.2006005382488763,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07438146674530098,0.034970498235057754,0.8036298987262369,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0701177883925635,0.07791231704553907,0.36993037558175923,-0.08413019354480838,0.22436577032993538,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13331819515808957,0.0964262004109215,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026854642278894406,0.07062001707706221,0.7044120377850147,-0.11295630843577535,0.16666559299356415,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12875622431727227,-0.00932744337548704,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05419422935936103,0.07811515933324861,0.48915398326913684,-0.10045533238871615,0.2088437911074382,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.45608312666393624,-0.06301970473932872,0.9413101379855534,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1117170251095952,0.15281490129296246,0.46615517193683154,-0.1908203788367009,0.41425442905589127,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.15337815983441752,0.1382595097991931,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14404112595319518,0.1448777136605984,0.3220971469856878,-0.14278252154256643,0.4308647734489568,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1946381075642808,0.1877800522791564,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10798795747141098,0.10314959755048357,0.29722959526392556,-0.09622387787311552,0.31219979281593746,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07238145034287123,0.14841816669329258,0.8843360296870468,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1774667806345383,0.14047811466895027,0.20890815531802248,-0.10064670020812833,0.45558026147720493,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0303323287480143,0.3359793463888759,0.8221680401162432,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11198352108006814,0.09420193061233567,0.2368617733439205,-0.07451404750160025,0.29848108966173653,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.17660925338612674,0.10611050593081571,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14819446147986512,0.1988772830123528,0.45762279664929073,-0.2455355766078597,0.5419244995675899,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.09291897794613999,0.40947226844342477,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04473090254815326,0.10376988312488085,0.6671927039566402,-0.16070895169895216,0.2501707567952587,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03330888457930566,0.15289582761166018,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15883592261571527,0.11936774921190323,0.185808525195938,-0.07748402168244486,0.3951558669138754,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.024012658169306443,0.291566052778239,0.8073060060237306,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07513775363910105,0.08862742966095473,0.3982269131127799,-0.10032361996513017,0.2505991272433323,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2701215051311811,-0.005250771956329276,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015839646799551448,0.09589788506749858,0.8690842274807296,-0.17401551095525977,0.20569480455436265,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.06414830772517612,0.1102699048652863,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06833444312892094,0.10127528062366178,0.5011284225593233,-0.13216668748448668,0.2688355737423285,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16749004708604,0.05976143293551433,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09105444557323232,0.14937532615184587,0.5432908476853002,-0.20467341215036466,0.38678230329682933,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.011097985252460241,0.23266218882649375,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05094017331499901,0.10315492948210842,0.6223271104995365,-0.15328221799454236,0.2551625646245404,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.21702525834467828,-0.01746544884174749,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1469697561815992,0.10771394915531073,0.17495982455167503,-0.06627841706936755,0.3602179294325659,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.28203570079937423,0.08924393273980134,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060198308944066165,0.0873841286977351,0.49220946306588653,-0.11280162246733016,0.2331982403554625,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10310225354040065,0.04037060515175845,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14742117957655682,0.09297238958480773,0.1154299400676171,-0.0366421882343331,0.3314845473874467,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.4463107645811389,0.04679475468881357,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09902174908291544,0.08872845078999841,0.26662967601314774,-0.07663962249184098,0.27468312065767186,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.32404337840662356,0.0067770490589702526,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15589219402170076,0.09370575935122034,0.0987732624606308,-0.029623072677229023,0.34140746072063055,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3757761927235116,0.01668180002704388,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05514658183200335,0.08216439237916803,0.5033891159362143,-0.10751950476620917,0.21781266843021588,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.03014680233726256,0.16385794213133978,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12659782717161489,0.09781480075710379,0.19804017837961857,-0.06705237080120019,0.32024802514442996,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08712865308759399,0.17437357697661637,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11644703073260787,0.08058634175532803,0.1510434779347541,-0.04309488842517209,0.2759889498903878,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1555337816592654,0.11580006013646539,0.7686319965021204,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1822825788215822,0.150784872416096,0.22906144615812796,-0.1162358475175119,0.48080100516067625,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0024761127946585824,0.44095662055930596,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12651669322547665,0.09140413337088256,0.16886128576421572,-0.05444189776280495,0.30747528421375825,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2895562146104545,0.002558574946086935,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0895653104384497,0.1310733437633127,0.49570970904913303,-0.1699289457708383,0.34905956664773774,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.06317570238106429,0.30546135454988527,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08652278221396317,0.10110824034578458,0.39383072289651266,-0.11364764811042907,0.28669321253835545,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03197321668197943,0.13161858829698736,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11814566963247254,0.09732549004413094,0.22714112074689854,-0.07453580872220712,0.3108271479871522,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.02804444401314157,0.23650304903435385,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060366165382348784,0.08764938406365291,0.49231590383359014,-0.11315890899029418,0.23389123975499176,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05939649562118952,0.1401735188015993,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09230639471791952,0.07100758899630454,0.19608863307405103,-0.048271856837819815,0.23288464627365885,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.012153485861670976,0.09984860482115716,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11358147807424464,0.09800876448055867,0.2487826072720845,-0.08045272224950152,0.3076156783979908,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.040969082805839226,0.2687272109892375,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08564681195183703,0.08695421789547267,0.3266069772877689,-0.08650199763214277,0.2577956215358168,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.027655176033904428,0.09912174658314875,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06766015519603577,0.08245812482824416,0.4135221473249914,-0.09558745226072127,0.2309077626527928,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08525066842357286,0.09376675159973653,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04781819312419651,0.07529533443163522,0.5265785339194722,-0.10124878146713638,0.19688516771552939,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.005198156803419814,0.06362487186051684,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12586282054351144,0.06894339985758018,0.07037713945966574,-0.010628824156482947,0.2623544652435058,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10869334076203369,0.16521836557697325,0.6139052011327766,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13679953755497976,0.08856217009882322,0.12503694903692342,-0.038532637532988384,0.3121317126429479,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09733656121050605,0.14315759461716235,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0021435846459430937,0.16444992427965688,0.989621434537328,-0.3277155854768829,0.3234284161849967,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.21428362510382423,0.18321856652754182,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0871281073231981,0.13028783657351728,0.5049380105353052,-0.17081103021656785,0.34506724486296403,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04522987074711875,0.23635761917703654,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10218832263793333,0.11932672895097568,0.39348365140113795,-0.1340504112341151,0.3384270565099818,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06738978894934261,0.2087609695349422,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07575162922858134,0.08039137521355115,0.34792401456435607,-0.08340430223489331,0.23490756069205598,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19703275249009833,0.012130515703083473,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12008855644835582,0.12283921364396042,0.33021891677608284,-0.12310406733511871,0.36328118023183037,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.046873623640836935,0.2822333135689281,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0833458152700473,0.1026537283315417,0.4184363890824324,-0.11988431616389035,0.28657594670398495,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07480890466356026,0.12715938506318786,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09333861018849214,0.09464489272894713,0.326003856616371,-0.09403591873979368,0.280713139116778,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09468455119444227,0.21028594272668982,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14671419058687224,0.10147114612278373,0.1507985775653864,-0.05417470744401645,0.3476030886177609,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16608341384508563,0.12446689670803714,0.7683177847971997,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14340630323187384,0.1388953017402581,0.30390763299124174,-0.13157358193178806,0.41838618839553576,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.009709145801723815,0.3360600506185437,0.8913059585247131,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07120861599232828,0.07266421651556314,0.3290571632542262,-0.0726493666939613,0.21506659867861785,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.4297267245946385,-0.030635617624963033,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08015398875747601,0.0901010791536765,0.375445547774805,-0.09822486271103828,0.2585328402259903,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3827249194856672,-0.01484721967366869,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1554089109278975,0.13958643359944067,0.26776388622439834,-0.12093925204566736,0.43175707390146234,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03563528639655847,0.26790960369172667,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1720932932398568,0.1469724913326559,0.2439310072282549,-0.11887751918149006,0.4630641056612037,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06573013835628402,0.2577377858138087,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11808171532735146,0.08712837923187002,0.17785889241900418,-0.054411892559252356,0.2905753232139553,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.30271870520084865,0.06252322616141195,0.7948003040850444,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05496187647045018,0.054979640358323194,0.3194618709446717,-0.05388482318497222,0.16380857612587257,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11987790262561339,0.054236558543073445,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0020587956850657194,0.04983515580876163,0.9671151657313375,-0.09660303988251226,0.10072063125264369,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04038438735836935,-0.005291196212467429,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07383887244041362,0.08032769328083268,0.3598090190500145,-0.08519098384034052,0.23286872872116776,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2504501343064757,-0.010540094883371015,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007444944186678072,0.11004504921658388,0.9461730490322235,-0.210418256492305,0.22530814486566114,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.32473713384498376,-0.10518670996806535,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13622771000280795,0.08351853155868819,0.10546779711961879,-0.029119252272368806,0.30157467227798473,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19886825340041048,0.10237535603256297,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07833620442233351,0.08989092982025905,0.385229731736066,-0.09962660101117222,0.25629900985583925,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3931769964866514,0.013827764939884,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09631493821230758,0.09638935653394635,0.3196783651262696,-0.09451321694206832,0.2871430933666835,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.22283860124110366,-0.01536117668293641,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037444269540379195,0.09518655805385026,0.6947328045649472,-0.15100262876954015,0.22589116785029853,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.31856542390938575,-0.028520796096818866,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004114041649235635,0.0612270584924639,0.946538805337263,-0.12532915333567105,0.11710107003719977,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.022628122389304037,-0.003780762189863606,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035611191254181614,0.06753235838858662,0.5989366343032363,-0.09808692467814711,0.16930930718651033,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13221016467846824,-6.658318616827427e-05,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08744931449346233,0.0741717811891526,0.24070712995445367,-0.05939329010319003,0.23429191909011468,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08009574636569121,0.07139099385440842,0.8476072767807353,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09320199557584244,0.09100862593703397,0.3078307774237233,-0.08697358412711548,0.27337757527880036,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14869823576880223,0.1156715412153155,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07854982090536397,0.0895641692073634,0.3822121840621726,-0.09876607570772622,0.25586571751845416,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2105451503980968,0.0916685554709913,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08754565174234236,0.15565658546234115,0.5748648177132049,-0.22061761554689402,0.39570891903157873,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08549578524928846,0.24181338013706238,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06009265046030142,0.06883538457173316,0.3843973039908739,-0.07618514949097945,0.1963704504115823,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2940972007504839,-0.08762736933802985,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08138036133675976,0.10473068104441924,0.43864921072969,-0.12596164581451097,0.2887223684880305,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05248000114611309,0.18894890620529384,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12451889692886282,0.0972122377650998,0.20267936109206663,-0.06793836866777307,0.3169761625254987,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2667455966607736,0.09134115929746094,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12700202866363675,0.11470839547882349,0.2704153444365638,-0.10009349595721054,0.354097553284484,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08483750369551364,0.25764733837280684,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06128034195721545,0.0966718118066182,0.5273420549297112,-0.13010700791051671,0.25266769182494764,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11732079000710449,0.09612025569842515,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11752530586676839,0.13122166456338452,0.3722317428656573,-0.14226259048772338,0.3773132022212602,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09911820604157669,0.17745120445471615,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07838110306225402,0.08580823261449146,0.3628250573305516,-0.09149892639010723,0.24826113251461526,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2608602155222256,0.024778812877444625,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056583867132291556,0.15927029894900577,0.7230062982581172,-0.25873369916581757,0.3719014334304007,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.01298957940909733,0.2516360040352968,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07994008630491418,0.11978535085494524,0.5058122513392036,-0.15720661059329138,0.3170867832031197,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.21380314983876025,0.12907615641134612,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039590819554793294,0.1426819778472353,0.781888173519148,-0.24288578974569927,0.32206742885528583,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.03500766235608532,0.28911297415046794,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12756643965283654,0.11492971681418042,0.2692208013768592,-0.09996724892761338,0.35510012823328646,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.26279191023899445,0.07621832535649045,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06223741208988563,0.13241005650839832,0.6391757882868083,-0.19990321957296397,0.32437804375273527,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03026599678970281,0.2844557925858848,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11025157421657486,0.10066845017061417,0.27560644174271165,-0.08904817545592161,0.30955132388907136,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.24176441398130094,0.06844397205452109,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05038212677584402,0.06136862473474409,0.4132748628245193,-0.07111325262704773,0.1718775061787358,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3512642277524041,-0.045750868731394605,0.9263451842579509,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049642448546409514,0.07903957667346917,0.531141216727794,-0.10683724115324161,0.20612213824606063,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14170268278486262,0.0018740651181276447,0.9462574637850627,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12654288543094577,0.08545860562373413,0.1412722814098154,-0.04264496517473024,0.2957307360366218,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19032577476341656,0.13354729449526612,0.7596261630193029,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1672357335316928,0.15582116079261693,0.2852927757270276,-0.14125335403262124,0.47572482109600683,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05069980788609831,0.3767050040272739,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02053212854769963,0.08225868865900486,0.8033165599673777,-0.18338489950366946,0.14232064240827022,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06446788570822709,-0.11305514116708469,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09958260507753469,0.07254619568957377,0.17239118529640116,-0.04404172425424352,0.2432069344093129,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11803463063656257,0.056117992073959844,0.7851068438799956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13183718591207638,0.08364027462033935,0.11758136395063798,-0.03375079886489035,0.2974251706890431,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04991424367072255,0.18009984339600962,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12748736929288573,0.08514233963077124,0.13690787482592653,-0.04107434936061857,0.29604908794639007,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0797164988711913,0.11350407902277418,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08998364000167276,0.07777309032738867,0.2495504536243127,-0.06398870592433638,0.24395598592768192,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11991363094539728,0.09343740838826317,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1207445264846083,0.06259384679914234,0.056070673621454965,-0.003176503162366298,0.24466555613158292,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20772005723086256,0.08384505535896598,0.5518846108576955,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07928967723443722,0.08309845506678816,0.3419021970470767,-0.08522563282460743,0.24380498729348188,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07807517017887249,0.08513263142531301,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12702907573484426,0.14565647253924432,0.3848733326335019,-0.16133633036856773,0.4153944818382562,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.028291320993903534,0.28124284883007605,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058818362931550794,0.11066209597377022,0.5960376297319203,-0.16026644455706368,0.27790317042016527,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07835618197812651,0.11798334462671146,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09400311829668273,0.05391780531145283,0.08379463670732532,-0.012741398811217733,0.20074763540458318,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10495917978837398,0.06048179148660856,0.6500804664849935,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12400812939207621,0.14889215263079583,0.40655776179567704,-0.17076315890355748,0.41877941768770993,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06974366921814479,0.26717452117466195,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11879400009740211,0.09703534003626821,0.22324211731588697,-0.07331304978602853,0.31090104998083273,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1876614086038562,0.13879678348402938,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11190061308265262,0.10122115786451627,0.2711336019816602,-0.08849336725347343,0.31229459341877863,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3065645886462802,0.05632997240722567,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024581155330103403,0.11523864436605817,0.831446863974122,-0.20356413682278482,0.2527264474829916,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06692821612521065,0.15229429842520892,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1083310637390901,0.10773499126240128,0.31664699631075083,-0.10495876791298067,0.3216208953911609,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.17370146003444134,0.19687910543709103,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06460477516843316,0.14395657057460362,0.6543933298168016,-0.22039522662561983,0.34960477696248615,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1522518577778572,0.052479488924932524,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056705780226120085,0.1329014029418068,0.6703738332421939,-0.20640760130041394,0.3198191617526541,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08818157966799897,0.12868744876946445,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1424458575959367,0.13083654072144402,0.27843602696752745,-0.1165795845322154,0.4014712997240888,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.007563899014828245,0.2944602766689452,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08254650918482363,0.09121123057113473,0.3672618307897838,-0.09803017983083685,0.26312319820048413,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14007497544925487,0.06304634504979531,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08518667546863609,0.17041125826143327,0.6180612523947417,-0.2521873583554469,0.42256070929271905,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3911638650806719,-0.0885357244644062,0.9572656024379023,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15244259606993368,0.11752781138401779,0.1970725576563481,-0.08023470599136837,0.3851198981312357,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.048438226493227744,0.22963644502646813,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10553731313533014,0.11047613532750158,0.3413331294399582,-0.1131793362045549,0.3242539624752152,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04325269840878561,0.15708168814144918,0.9043732915535342,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.100235172401357,0.08155583831210592,0.22144259605972447,-0.06122612090737799,0.261696465710092,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3167414308587802,-0.05134310988461507,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11201545040544181,0.09686017000109867,0.24976893797707275,-0.07974480419008839,0.303775705000972,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1239331148603677,0.14500756389382524,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06581867632211041,0.06804416529064689,0.3353267708488451,-0.06889269636830281,0.20053004901252364,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20398267082733848,0.009658797345849622,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08867402533666549,0.08691192751193702,0.309633887864262,-0.08339105927848917,0.26073910995182015,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2871141087369391,-0.03758743897858969,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009309635198793261,0.08832282302034006,0.9162292712494888,-0.16554868921653917,0.18416795961412571,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.01594755984751369,0.1619614078319935,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12229691634286559,0.07935454632979747,0.1258925388761969,-0.03480633886866412,0.2794001715543953,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.019226612556187756,0.10260319674151908,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16038211783443523,0.08435736516584155,0.059651160830393624,-0.006625536818931577,0.32738977248780204,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10897116115718977,0.18493911739905888,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040874946064507006,0.09110860861586526,0.6544939381268259,-0.13949857572287644,0.22124846785189045,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2311828137705182,-0.011619168507130035,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1431745605023501,0.15825435015755293,0.36741597015244076,-0.17013166719390843,0.45648078819860866,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12487037587289798,0.25959748938950716,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14362715916851032,0.11050408884225466,0.196159000071297,-0.07514483152691673,0.3623991498639374,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2772979865587529,0.12588008291136213,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05493888885881167,0.1464164720329046,0.7081512350878654,-0.23493113670164975,0.3448089144192731,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1465911661166859,0.07868411892633168,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16556326248472322,0.13995781559378376,0.2391476134908855,-0.11152014910327848,0.44264667407272495,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20858591113145855,0.24681016093448935,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09366179676229759,0.07501176435604817,0.2142115863629696,-0.05484377606926523,0.24216736959386043,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14882343107909118,0.10154749718276826,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0698539888504682,0.12259967919312678,0.5698879969828157,-0.31257239100831746,0.1728644133073811,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.4425606316234179,-0.06469866129395715,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10543885240779485,0.13641147178136828,0.44106098326053356,-0.1646236362111024,0.3755013410266921,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.022914920455804736,0.25359813044205626,0.9321464550378369,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06122098334672773,0.09055358668457282,0.5002834435530011,-0.11805372613370299,0.24049569282715846,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10137383512993314,0.05507026417635926,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011846913904507412,0.08432241931222524,0.8885021837585376,-0.1787853840232358,0.155091556214221,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08435856990746926,-0.02397113960669492,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06879522192069937,0.06962350184043517,0.32507376278979383,-0.06904286403974003,0.20663330788113876,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16914842290958146,0.013026052796496587,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03175533199186234,0.0942234842974222,0.7366846258059739,-0.21829557177821285,0.15478490779448817,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11978535008899743,-0.06247363607080414,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03570899621176819,0.09783264699688672,0.7157479893234564,-0.1579765330998656,0.229394525523402,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20441425881970282,-0.012354572863431095,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020308993328281573,0.06713599888001613,0.7627863136454834,-0.11260442441206614,0.15322241106862927,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09712370832346663,0.023027008671214617,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06052560361652802,0.06608109517449158,0.3615258614575557,-0.07029935399471955,0.1913505612277756,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14016172668071972,0.029093377088016712,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06548540575816743,0.07944508772553856,0.41139944821061314,-0.09179710002765458,0.22276791154398945,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.062346664136532906,0.09416614464270727,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05818065178533702,0.06764160014556907,0.39141773992101025,-0.07573373701881486,0.1920950405894889,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09176876533334669,0.0383938039702422,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10699733896769707,0.08709530504775792,0.22164015632970846,-0.06543078984772811,0.27942546778312227,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05385085830736442,0.11194621838081813,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03530659748967321,0.06648940819185543,0.5963846130831006,-0.09632672343709892,0.16693991841644534,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12390328328764834,-0.020044699955084764,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03691358099824264,0.06283595336980703,0.5579897763733197,-0.08748676246399147,0.16131392446047677,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06522770167505264,0.027716693771676508,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08495572941161594,0.09801671880425028,0.38779598319255404,-0.10909421859392987,0.27900567741716176,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1754584873918958,-0.03388815129113385,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020775608771271336,0.062024682761087184,0.7382374096868887,-0.10201861053825662,0.1435698280807993,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11198332667281145,-0.014277554209011426,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05579233548987222,0.07710391344497541,0.47070836487625345,-0.09685519829364786,0.2084398692733923,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.020821784706828106,0.03924700043679474,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05449698871640886,0.08852227852687578,0.5392948661011594,-0.1207562104829895,0.2297501879158072,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06323325449505489,0.07804774645039371,0.9471659478826966,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03205185139085115,0.06556410684150953,0.6258237597797293,-0.09774959145313519,0.1618532942348375,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09994691405974786,-0.024207690270784763,0.9600126145781049,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052578760145740776,0.08046876694604217,0.5147344114390673,-0.1067303886652349,0.21188790895671647,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09255003097692675,0.04579889153743865,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0056729492584469444,0.06648585777450654,0.9321435198096506,-0.13729924119761006,0.12595334268071617,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.019699553279393805,0.07742903299673798,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08976511604662007,0.08106629172649948,0.2703584505216433,-0.07072699067188698,0.25025722276512713,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2834625737484844,0.00033637715862394363,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03995022720776519,0.08927252536370597,0.6553079576243573,-0.1367882834921025,0.2166887379076329,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2014883875023568,-0.011079897676485555,0.9604336667767839,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09651658553447545,0.056620316075306806,0.09011236785791381,-0.015262403978937925,0.20829557504788881,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.015123233961254659,0.10895465756768803,0.6623259037556665,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10482281604176939,0.05521019743795385,0.05932969800376642,-0.004172338140034343,0.21381797022357313,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.02129235282027423,0.12627096712892985,0.5680556875544357,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03946728655280203,0.03737602472810261,0.29250629409407813,-0.034319907969019126,0.11325448107462319,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.016919279101109696,0.013947099960850926,0.8801800464438181,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04940101554751615,0.06474409420922998,0.4465217700222128,-0.07841581645397759,0.17721784754900988,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.08578495712250188,0.2136163232436543,0.9330352189956562,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05909954960131111,0.04310414576077664,0.17217647348571843,-0.025996016636260194,0.14419511583888242,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.016086332759398286,0.12634028639399308,0.7850787711519817,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062451528671284305,0.04083895317443912,0.1280919104267698,-0.018172127907264295,0.1430751852498329,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03168161958528909,0.017687321694739386,0.7288842902994255,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029602145421247124,0.05085326508968934,0.5612735894893128,-0.07079161743982348,0.12999590828231772,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.055632883182156506,0.14192719463269063,0.9509691818071948,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04223740474778219,0.03618536281430229,0.24476303227332852,-0.029199202656162562,0.11367401215172694,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004714673446701024,0.04974349076418435,0.8534526629046483,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04557414964050917,0.035423141066216836,0.20001625320976055,-0.02435769087600209,0.11550599015702043,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0028543522047958687,0.08323296514285677,0.8150559640549688,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047618564099120554,0.06052833964094639,0.4325569659504319,-0.0718755876641961,0.16711271586243723,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0647033448633416,0.18965809447019838,0.9302388919528202,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0664267068664763,0.03925430374757748,0.09245888739033088,-0.011068558280417029,0.14392197201336962,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.012599672410218742,0.10664874770902665,0.6674195391201606,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05074451614888359,0.06332294856432677,0.42405486272397186,-0.07426671116599223,0.1757557434637594,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04312547267045335,0.19041329313147623,0.9291050235448216,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07268778140476626,0.0450555010005324,0.10855740498608084,-0.016260121449780063,0.16163568425931257,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008208142766704816,0.11567293362626323,0.6983214593026821,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054847147752167646,0.036935228732027495,0.13942972940378245,-0.018069833841889177,0.12776412934622447,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.010494965251012957,0.09298759437663107,0.7554902334520308,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12525119260872777,0.07797431730427912,0.11008301947611979,-0.028684549902461554,0.2791869351199171,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.1360759656968716,-0.030148062158069894,0.7000359361715495,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13443390764759158,0.06251621230389652,0.0329546433550294,0.01101532711121106,0.2578524881839721,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.13598080877057353,-0.10646911307594875,0.43476822754237954,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05398675286309539,0.03107877009819899,0.08420333576016004,-0.007368494823545964,0.11534200054973676,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.036264121237790166,0.056248836292388665,0.6514679135128171,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039398200071260644,0.043531265296040476,0.36673221116526467,-0.0465405792276742,0.1253369793701955,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04838347504714885,0.11517982547511299,0.9150244079451123,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04493410049222844,0.03732213758371615,0.23030131664385375,-0.028746710827152258,0.11861491181160914,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.009271601965525903,0.08969492029590354,0.842940686827401,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027141793732291072,0.039021789660984456,0.487668690099054,-0.04989444554811935,0.1041780330127015,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.038713854227164696,0.08070141975065527,0.940275458344982,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0723863107889067,0.056763416050212026,0.20398912290621388,-0.03967518457581676,0.18444780615363016,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.018313735507893784,0.09085445817775273,0.8179445630780711,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02309239185181016,0.052208094989816045,0.6588306186998647,-0.07997605613460132,0.12616083983822163,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07388240869954714,0.11893075496323322,0.9604336667767839,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04071924262850692,0.03937376026736604,0.3025421111302372,-0.03701185181073783,0.11845033706775168,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.00991775288410645,-0.006358092688500847,0.8904632102898862,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06496531545688676,0.06115277667536562,0.28960403174863053,-0.055761590652578366,0.1856922215663519,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05752668403577898,0.18416279495231289,0.8780447660402404,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023292819807663095,0.03736589752178013,0.5338860886264922,-0.050474381733408624,0.09706002134873482,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05200308279551604,0.08731086909050662,0.9464658142652354,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05095888897598115,0.035442903887974234,0.15235822195622084,-0.019011967010578668,0.12092974496254097,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.010416832597775413,0.0982113490864465,0.7692078902000675,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047491608335989755,0.03487612331052985,0.1751086955123539,-0.021360317827954806,0.11634353449993431,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014408804829123578,0.017539627335626674,0.7896200758961603,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05360886667554321,0.03586903180164405,0.1369019938221488,-0.01720324472771402,0.12442097807880044,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.01566843045415989,0.09099146061748305,0.7473242853882033,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053285639616509145,0.036616493828519024,0.14746994568827687,-0.019002100251142517,0.1255733794841608,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01658878561297271,0.057960584418964387,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059983519170364014,0.03581459074251806,0.09582711951944194,-0.01072111550017682,0.13068815384090485,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.023653584210431695,0.11706484737944545,0.6734224093863465,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07861698951824367,0.03483093532949884,0.02529002462321507,0.009854272797267943,0.1473797062392194,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.027596617402554525,0.11448782487239884,0.37388200177512143,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035907483121403364,0.054539350758987436,0.511196800553035,-0.07176329548126088,0.14357826172406762,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04455792462336167,0.12206995576261008,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06235210182738111,0.05771923497496918,0.2815723035800765,-0.05159635710400721,0.17630056075876943,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0351756291814886,0.15261641631851108,0.8768618853741261,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053753960667280935,0.039743319794425046,0.17802405400141205,-0.024706712717527606,0.13221463405208947,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.011753621512115618,0.05510482494521441,0.7948003040850444,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06771022025321466,0.057403889752420556,0.23985061617303624,-0.045615688809722096,0.18103612931615143,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008770976069087033,0.13225172912772973,0.8466912699522725,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028684080058232288,0.0352680628129242,0.41718805705528283,-0.04094160726716114,0.0983097673836257,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.08507872627877414,0.10266331905532186,0.9275420473817595,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06029134319868495,0.051096143513256774,0.2396847136141405,-0.040581906649439385,0.16116459304680927,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.00798973417428148,0.09815781415990595,0.8466912699522725,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04206834868581121,0.03794804553721588,0.2691969876878068,-0.03284812084638405,0.11698481821800646,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07004074288370062,0.09946866291235046,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05871560694227676,0.030185402271553183,0.05342445111450407,-0.0008759672107614622,0.11830718109531499,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.051599514122686735,0.041989750178868725,0.5416134009539378,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0318427300504379,0.028597699712199286,0.26709645868796594,-0.024614425221992246,0.08829988532286803,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004318244922376634,0.08148683684760788,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03459235661852921,0.032494930795226244,0.2886089620084807,-0.029558654544454756,0.09874336778151319,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.02433964798341697,0.038153199044655965,0.8780447660402404,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058236487419694005,0.033865834908526106,0.08734254053085781,-0.008620942342236482,0.1250939171816245,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014502598511743695,0.09600956589745178,0.6570209000268399,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04552976039016963,0.03195896507014435,0.15611860452587037,-0.017563155175400226,0.10862267595573949,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01232406380455494,0.06742617507253075,0.7759984237485028,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0611595478078468,0.032957232462578555,0.06524463645020391,-0.0039041324606624295,0.12622322807635603,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.028393350992126996,0.10150994822752657,0.5905495144147305,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02851874139348251,0.027636848849138567,0.30359750961688914,-0.026041516334201167,0.08307899912116619,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.009385094970884337,0.05734817336648761,0.8913059585247131,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07128271258036308,0.029158129251155736,0.015530399906622977,0.01371916561144891,0.12884625954927725,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.02287796026010921,0.07542453314970732,0.27154254286073387,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035782950327075826,0.03359155731415741,0.2882975207244008,-0.03053300466979108,0.10209890532394272,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.010365181269948464,0.09592214393106739,0.8780447660402404,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07139728595302236,0.027018811288437597,0.00900749415144554,0.01805714882524148,0.12473742308080324,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.05031133520828345,0.043059955971302195,0.19636616606057228,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047667651812271804,0.025434115297793578,0.06264430837525117,-0.002544001958324174,0.09787930558286778,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04527009961038247,0.03661719767441459,0.5816029472312793,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08671986082840644,0.032496769203857905,0.00836409743569312,0.022565220306326572,0.1508745013504863,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.027839830627376837,0.09172352328751697,0.18755425266816944,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02749373237336644,0.04137954746895263,0.507327312424644,-0.1091846222025572,0.05419715745582432,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.11805735373376072,-0.017327076833311188,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10228624919711211,0.039436847295482524,0.010333952602980255,0.02443060928120691,0.18014188911301732,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.08706148957163477,0.07528261912631301,0.2066269918449805,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06286980707861892,0.059497061764462324,0.29217130983488093,-0.054588411172994844,0.18032802533023268,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03526346348042933,0.07582339239079236,0.8799526010712531,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03206915563491229,0.042526506067886466,0.4518460039821207,-0.05188604287514184,0.11602435414496642,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05390224659924871,0.07608523316169336,0.933731420853472,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04867490371049312,0.03964073988537828,0.2212017283372037,-0.029583257936967026,0.12693306535795326,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004149852853373809,0.10043775670390916,0.8355377918591873,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07286397685298404,0.04742438672906406,0.12631557891425474,-0.020760545126327204,0.16648849883229527,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04197294070665531,0.21462322086852426,0.7263564310373228,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11264709301362089,0.040402666936817586,0.005913158601061441,0.03288474626448196,0.19240943976275982,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.11288435138634059,0.052866331089112976,0.14734065795407886,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021885897363342233,0.0604620627186614,0.7178238506693038,-0.14124920620816966,0.09747741148148521,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.16812981451073167,0.19562816548901565,0.963305304214035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08752921613288417,0.04261795972150964,0.04154368632287755,0.0033934711741717277,0.17166496109159662,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03716985773596558,0.11277399198743186,0.49032550277088105,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028071676942200852,0.03919832697556525,0.4748962304180502,-0.04931307969033823,0.10545643357473992,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03734433424273603,0.11397644374816757,0.937664825139976,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08449324833632414,0.02818006657281333,0.0031270627083472293,0.028860578222998146,0.14012591844965014,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0636450268495391,0.0429919825264728,0.09026408646858294,0.862626369566384 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07305229542354107,0.03453086227132877,0.03585598497267568,0.00488197849026413,0.141222612356818,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.025298990508936744,0.05021289035635856,0.45322421769601834,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06591466852976392,0.038753632551961605,0.09081869160911961,-0.010592178957115256,0.1424215160166431,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.030403228870171002,0.08632717156597633,0.6643433245175604,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009134939812805045,0.05341084506038966,0.8644047733767326,-0.09630795955157283,0.11457783917718291,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.10582007486578791,0.12749098673304002,0.9854445582989166,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07521012255306746,0.041742903544855305,0.07337833754674393,-0.007198099460280313,0.1576183445664152,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.016852872057297404,0.056802547040245795,0.6234452489529284,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031818664214678875,0.037339479397207685,0.3953465483340871,-0.04189638305608429,0.10553371148544205,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.035390551960152804,0.07582575374918164,0.920957044807631,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03452762685445928,0.043426648324057536,0.427689240640453,-0.05120461916764516,0.12025987287656373,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.02547926859185464,0.07434387906410345,0.9299900056018157,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051140368797670116,0.03952136025934289,0.1974438393726775,-0.026882115359947403,0.12916285295528762,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.016562986789779664,0.06251573523600534,0.8150559640549688,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04984851202223269,0.03685437687807288,0.17800736301699951,-0.022908853039070885,0.12260587708353626,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.011457482808970925,0.06666446862939492,0.7948003040850444,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034800253302732516,0.03508720907674627,0.3227108975136145,-0.034468395254936494,0.10406890186040152,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008130192410640136,0.06023897372588842,0.9034998483867911,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05485436098701605,0.031105604886205212,0.07963608949254249,-0.006553863540714508,0.11626258551474661,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.003542029892037979,0.12232550630672949,0.6378354016929029,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030913511403586683,0.03294118848529129,0.3493627126371467,-0.03411849508255507,0.09594551788972844,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.01264257862526798,0.10979441217777634,0.9086977961712401,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03886745581656799,0.032101454714183186,0.2276843968606575,-0.024506760694153834,0.10224167232728981,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0032310167470730173,0.068138829535259,0.842940686827401,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08024810540248813,0.06444424329333473,0.2147801251771965,-0.046976765361296094,0.20747297616627236,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03304780443211596,0.1646931129563136,0.8289622204693651,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043715214118681206,0.03311758798110119,0.18863078662237553,-0.02166503763981263,0.10909546587717504,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.010750974000502489,0.05364345577091717,0.8085168201280608,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06970560977232007,0.04703894896396673,0.14024812767061295,-0.023157986679030768,0.1625692062236709,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.001802417489077265,0.1640242527147687,0.7568502146876953,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0471581744837522,0.03336456468217457,0.15938218907543666,-0.018709655020556784,0.11302600398806119,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01736713029383456,0.07394152280013233,0.7804909419375794,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051720559839775526,0.03288936831999898,0.11770175005248078,-0.013209144043443838,0.11665026372299489,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.006921005016977208,0.12036033619819961,0.7176009922554474,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040753283865991634,0.03619579578020225,0.2618085482127935,-0.030703920144732465,0.11221048787671573,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0070233832583725874,0.07188190969017598,0.8669652730965864,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04267736669838468,0.02998051931946892,0.1564448221853384,-0.016509730564732192,0.10186446396150155,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014696202845084489,0.06156574021508007,0.7769533851405084,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06462447159192398,0.03824959202240061,0.0929696130322105,-0.010887306545762615,0.14013624972961058,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0010957407271590138,0.11856425004446304,0.6696849258164128,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02675248941477329,0.025676027969446732,0.298943620198048,-0.023936744769748934,0.07744172359929552,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.019668416112286844,0.049711774029442,0.8861144350754685,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06020620899355679,0.031015470706583722,0.053911451652560144,-0.0010240739715496675,0.12143649195866324,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.013096915383992262,0.08039390106534157,0.5431638761740712,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024822346780281335,0.02660685510863702,0.3521947037653087,-0.027704512557939542,0.07734920611850221,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0024309724828678416,0.05502472311119392,0.9090812501778921,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0434715384886657,0.03201812965926609,0.17637455866456261,-0.01973817893258805,0.10668125590991945,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008705665423039625,0.08389193654197492,0.7917994815735138,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03401087188190067,0.03147021238382684,0.2813652262561005,-0.028117155368212333,0.09613889913201368,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.016287233553508616,0.07392616286282398,0.8768618853741261,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040771953284438014,0.06032928597880016,0.500081907203731,-0.07832922968682782,0.15987313625570385,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.012769386626672012,0.11335736361886596,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058084512687876275,0.043255115327336294,0.18113663023079177,-0.027309095432309596,0.14347812080806216,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06758508613057045,0.12900503148102047,0.8014130815101496,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04646936070253699,0.04290537030189781,0.2803310016599108,-0.038233785967754105,0.1311725073728281,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.030178563144748274,0.1308268930666293,0.876035315676277,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0548465313837013,0.031772795694554386,0.0861479725875473,-0.00787885135753548,0.11757191412493807,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.049242778491329214,0.023000070561201763,0.6550216536397994,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0741514902662029,0.04797849730939606,0.12410336682984438,-0.02056694861505258,0.16886992914745835,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.005774568426237365,0.13525994906214625,0.7259506085296737,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057393268707474576,0.034264507785280826,0.0957933712637119,-0.010251215143853395,0.12503775255880256,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0071890577751158,0.10197153661674453,0.6734224093863465,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07611954800970455,0.03887133058569372,0.051857422512302714,-0.0006196571923946098,0.1528587532118037,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.010336295802993636,0.09603663706742314,0.5339911008653665,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031181658627226945,0.036330939992784465,0.39196769856312286,-0.04054234508664494,0.10290566234109882,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03337126555852379,0.09666888023132297,0.9200851777021611,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07917648751243331,0.04601073862161064,0.08712342126822115,-0.011657231307663399,0.17001020633253,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.029719757913442946,0.15965935977739718,0.6570209000268399,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0212176192365953,0.03080501158703699,0.49191704948176074,-0.0395971784513621,0.0820324169245527,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.017215977006853976,0.029800906098011098,0.9421219642690486,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08081177387406767,0.032783382984816895,0.014706078415053997,0.01609130467004255,0.1455322430780928,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04609343992706552,0.02059698813895542,0.264709411470972,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06391350841335497,0.04397203391051023,0.1479494455802549,-0.0228954297569844,0.15072244658369433,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.013744331285187558,0.13013000664014512,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05538848677936768,0.03806542481777309,0.14751126681411914,-0.019759711190250023,0.1305366847489854,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03005689621511605,0.11666099626208813,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0366725404560132,0.0332260461982138,0.2712892611891908,-0.02892182790856157,0.10226690882058798,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.005096761574861922,0.04506579992234474,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0533888085769919,0.032114916301862424,0.09829118055253809,-0.01001198360077548,0.11678960075475928,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.039953605896150816,0.063119843104613,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06052256648563724,0.029994916865672107,0.04520762315053264,0.001307045800017316,0.11973808717125717,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0555584541619676,0.0331940384613486,0.5090185993885504,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05839885162771437,0.032445511172673344,0.07366986327737844,-0.005654596048274049,0.12245229930370279,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.025244258663694407,0.04436160113197871,0.6234452489529284,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09522595475958544,0.043505936795179175,0.029990836276219277,0.009337178611964703,0.18111473090720617,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.08160453953293896,-0.025433194029132942,0.4125949018381779,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03895799959540438,0.03548268663616695,0.27380008946244133,-0.031091394903500262,0.10900739409430901,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.018121721140163166,0.07060035272468257,0.870270919138952,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0866006975077879,0.04224239656401022,0.04190974244062781,0.0032063837729477684,0.16999501124262803,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04699782178753058,-0.006261051320837262,0.4906777809641646,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07383522833341094,0.033128526533172276,0.027157057874695283,0.008433381847405871,0.139237074819416,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.031430881620966716,0.04917504430102529,0.3910019750822703,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08693128845475684,0.04553927843001125,0.05797591011568404,-0.00297168063687335,0.17683425754638704,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03069376671855423,-0.0052693891587204745,0.5639862432577204,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0382362308157653,0.024180863694944682,0.11569946313297404,-0.009501272199716651,0.08597373383124725,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.023777279827953694,0.03956633905235755,0.7154246045700844,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06270297337756625,0.027814290859105424,0.025466632855533626,0.007792412261520276,0.11761353449361223,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.031479171525661716,0.05005397108422965,0.3742940281840044,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04070725597925416,0.03114631214385214,0.19300944868058836,-0.020781332213694798,0.10219584417220312,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.005799993832484758,0.06930704142234204,0.8140390093255331,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05380707287826203,0.03244093851860419,0.09905895746518312,-0.010237347531778865,0.11785149328830292,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.009964028026830234,0.0959594951270996,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018481404129633523,0.05042662635959049,0.7144524992825458,-0.08107009486851009,0.11803290312777713,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0261993098593521,0.09193390242025784,0.963305304214035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02671048095233331,0.04447090752818273,0.5488970781441853,-0.06108332612626446,0.11450428803093107,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07520230325584266,0.130877095388005,0.9485922053772787,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04177710370880972,0.02683434033500856,0.1213873766288884,-0.01119885359451648,0.09475306101213593,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.023070313994285302,0.036918211835394524,0.7228579124835106,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020743251700822054,0.03637111037890361,0.5692211491235174,-0.05106005579444853,0.09254655919609264,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03737460655412278,0.0865581310466185,0.9525219182038099,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03125396588027754,0.0328746653127373,0.3431220501414799,-0.03364671154374062,0.0961546433042957,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.045466463785921556,0.11681547955808635,0.9046447408422388,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04090010098165165,0.0398365640905048,0.30603890795166466,-0.03774465391163561,0.1195448558749389,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.018758029459376428,0.10459727315620901,0.8944539216937829,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04279395132677278,0.035972756100522155,0.2358738624123691,-0.02822293105129075,0.1138108337048363,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.020469698431153625,0.09505945062583161,0.8449482942840995,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025038902906762615,0.0392767654887538,0.5246676536873713,-0.052500705876928164,0.10257851169045339,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.01757230952207025,0.09746713773189315,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05216667383721277,0.038438387393514795,0.17655392824201555,-0.023717821326282834,0.12805116900070837,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03782654361939794,0.022658127569193276,0.7917994815735138,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033434900093834805,0.051725431954430336,0.5189076399319614,-0.06868068167580858,0.13555048186347818,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06869943936775308,0.1775949997319343,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02870196895161535,0.04713540587138733,0.5433960767311004,-0.06435205129794819,0.12175598920117889,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.09285682262592386,0.11626743380361353,0.9485922053772787,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09571551718828242,0.05567167051004075,0.08740414089548286,-0.01419067029854415,0.20562170467510898,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.006971291163192192,0.1625565262907414,0.6570209000268399,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04588553947545563,0.047811514179731784,0.33857666878083126,-0.04850324378404678,0.14027432273495805,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03751222129860061,0.0871950310164386,0.9034998483867911,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056504700392524816,0.04407090545651041,0.20156291552803415,-0.030499428519753007,0.14350882930480263,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04024926839022429,0.1423975778129697,0.8177134279159035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0415014187629264,0.03332585979448631,0.21474762745853612,-0.02429000012528376,0.10729283765113656,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.023382784421980825,0.08552614937739661,0.8289622204693651,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0371843648107043,0.030654829211973395,0.22683193318346848,-0.023333945056432645,0.09770267467784124,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.044656029680555674,-0.04193977805450193,0.842579263271115,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07442566926024252,0.03503707304529951,0.035116923661156096,0.005255998513398127,0.1435953400070869,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.06944854458790259,0.12237613931124432,0.4493241481738629,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03831938408255113,0.03758103502258049,0.3093620752786582,-0.03587253872665906,0.11251130689176132,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05714446161594353,0.08913500531264874,0.8972291390434742,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06266425144391313,0.05681096873692715,0.2715913026845183,-0.049491121730722135,0.17481962461854839,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07173207396829624,0.2035947086401911,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025147053733786173,0.030135402759626326,0.4052018628199625,-0.03434581212324193,0.08463991959081427,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.051548366318811156,-0.05608073874264109,0.9237532919369174,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04964316971990826,0.028974191557458714,0.08849127274915011,-0.0075572501780172,0.10684358961783372,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.039896936497020453,0.037621840270309695,0.6595715709697217,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007388044536793675,0.03775826811452118,0.984412252710475,-0.07528061820837845,0.07380300930101971,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06814392121429272,0.08192925937408185,0.998871063691614,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048878531820962384,0.03355347705059048,0.14705595477894223,-0.017362245683496064,0.11511930932542083,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03552709242323638,0.04985932180069042,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0033341660384875304,0.035005091562896176,0.9242313348424815,-0.07244069941638064,0.06577236733940557,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06747996778497307,0.07333852346799571,0.9915432628301946,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04913925708360783,0.02553227495862387,0.05596999614363921,-0.0012661820357664222,0.09954469620298208,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0446436062236304,0.059847300526655656,0.5518846108576955,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04783276862518944,0.029608105288434355,0.1080724851268895,-0.010619114372887054,0.10628465162326593,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004421554062351099,0.09661533724756638,0.6968963338239227,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06627761300155934,0.05149084811175125,0.199804671329854,-0.035374856819786804,0.16793008282290547,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.012057397629343195,0.14955363630005403,0.8150559640549688,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060640321317441945,0.042970675480299036,0.1600341452064767,-0.024191749868953463,0.14547239250383737,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.004504166748419373,0.10261567849372742,0.7815068115919459,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05105162057780942,0.031051875620236292,0.10203068372007176,-0.010250532428714598,0.11235377358433343,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004075600933347266,0.05002886560365675,0.6834764281602781,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052194626454596396,0.0533172041317512,0.32901460399520643,-0.05306340837517905,0.15745266128437185,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05606186714544462,0.13929968021511685,0.9034998483867911,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035913059739855695,0.03990982982953319,0.36948545721555726,-0.04287633529043918,0.11470245477015056,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03395556010878438,0.10216907879936935,0.9150244079451123,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08555707657150743,0.03855665427853558,0.027826597636662148,0.00943910067500181,0.16167505246801306,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.05183896411550754,0.054602028684983824,0.394442021499686,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029556464572504743,0.044708904835083364,0.5094622559407739,-0.058707193264906934,0.11782012240991642,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06473962040924938,0.14745909835882948,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04548471900661701,0.045169747564549494,0.31539585931260056,-0.04368872772275024,0.13465816573598427,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03406566184899592,0.03639431895980652,0.9025176929330414,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049577695619770025,0.04438286331381014,0.26556968433882394,-0.038042295874648004,0.13719768711418806,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.043613380503326846,0.08978529207994233,0.8693121373799397,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004177114340644038,0.04962126936207692,0.933013611254778,-0.10213868948071714,0.09378446079942906,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.09921306069100164,0.09042977854263089,0.9919986667747693,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03954183812062764,0.047202866236317496,0.4033894089678447,-0.05364536138236979,0.1327290376236251,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07223653018145892,0.14730208068614592,0.9235345118679857,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016321100317063436,0.03956630505902044,0.6804989053954207,-0.09443231383262302,0.061790113198496144,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.047202014411801586,0.010247124715451328,0.9621831471002781,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03109345509622783,0.08043480986252234,0.6995658564762048,-0.1276997553863501,0.18988666557880574,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0629499396893332,0.1035942602055031,0.963305304214035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007448381775819776,0.03813651871358617,0.8453875462614135,-0.06784016871009241,0.08273693226173195,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07027517554640828,0.12757845659657538,0.9824089645441008,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0064949571389821175,0.033561816835508206,0.8467837870482877,-0.059762284645358175,0.07275219892332241,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05959375983986573,0.12016695500040125,0.9824089645441008,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04706647362293903,0.03858035721981187,0.22419001448891623,-0.02909829626922067,0.12323124351509873,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0025506841052593153,0.032705988073321486,0.8362877514158915,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02108345744518785,0.034014815787466846,0.5362084408254251,-0.04606808816171014,0.08823500305208583,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0470810461331702,0.10449380898080267,0.9471273828544232,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07771494381376519,0.03613867754755955,0.03294823408984226,0.006370501772068285,0.14905938585546208,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.045474952717515144,0.04349535514889311,0.43476822754237954,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06361989532223024,0.037697169142124606,0.09333271870486527,-0.010801297745969773,0.13804108839043025,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.022098594486277087,0.03936938457227199,0.6704521782043941,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05100437519729668,0.03472654712955811,0.14377244850856663,-0.01755225988522654,0.11956101027981988,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.007849533539092934,0.09219208527053592,0.7626680424539931,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041604351413838454,0.029863357912558307,0.16541287469552052,-0.017351447534782613,0.10056015036245952,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.037522742258974666,0.06846462394837662,0.7824698350312412,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05271123105925434,0.03807914205944244,0.16811648378701666,-0.022464047285730253,0.12788650940423893,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014790932051580337,0.10568749651931225,0.7842677313995,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04233256624184013,0.037914220845977786,0.2657874221996868,-0.03251712708581807,0.11718225956949833,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0033894408706057286,0.02362512858758424,0.8693121373799397,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03854228980664315,0.06078143498952181,0.526869635411163,-0.08145151904577698,0.15853609865906326,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07307707997825226,0.16191506402928396,0.9448126253726593,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0604734887609555,0.0408390064427702,0.1405388279729986,-0.02015027297914347,0.14109725050105448,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0038996054629033576,0.07583305004904649,0.7568502146876953,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025988733389003024,0.046754893231558924,0.5790525292718385,-0.06631408444197052,0.11829155121997657,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07649237791292647,0.10613327784153868,0.9525219182038099,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03637431939799211,0.054279793860922916,0.5036973382929408,-0.07078404582025549,0.14353268461623972,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05810383550532169,0.13235046684386692,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05197064051974433,0.030872799650643108,0.0941589360556085,-0.008977983359520172,0.11291926439900883,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.007944748072794104,0.10448537867963288,0.6707240267079618,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1152829951122663,0.048651398469591656,0.018943610587396294,0.019236124725453232,0.2113298654990794,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0865304874146947,-0.005544190427376137,0.3146632024742357,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07435267003863204,0.05455516152597972,0.17474123506571423,-0.03334932194608892,0.182054662023353,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.019567200724359798,0.14767062621478003,0.7896200758961603,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03918347163489627,0.025399602025015473,0.12478983961216415,-0.010960046543683474,0.08932698981347602,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.041549804246522715,0.06290078809982963,0.7261583573371491,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06755690048642699,0.03145379403961432,0.03316169032721889,0.005461286088321353,0.1296525148845326,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.07893226097079895,0.05354252541556454,0.43476822754237954,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056291313903294886,0.030826860758672792,0.06961841938933273,-0.004566618095744539,0.1171492459023343,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.027143206481286798,0.0590568356916745,0.6099680056429616,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08559336371484205,0.037963778662574714,0.02544979813551785,0.01064583407955308,0.16054089335013103,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.09369925184658273,0.056269276417606554,0.3742940281840044,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07488186078940574,0.03274404252808331,0.02345043937866991,0.010239056932476676,0.1395246646463348,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.06848037207089491,0.044259682543384055,0.36184220356199315,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046952721455408054,0.028366690532348686,0.09974956281391531,-0.009048378915144144,0.10295382182596025,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.05115288177876216,0.05627018292196654,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04954371059740454,0.02739060331063558,0.07227245632609695,-0.004530412834782782,0.10361783402959186,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.022683511393751493,0.06550054009837487,0.6222329265906265,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059684351997133005,0.03025237294059975,0.050149740088091546,-3.943465897754406e-05,0.11940813865324355,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.052532712846205094,0.06406629242423749,0.5271148591877783,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04729195753462142,0.026894177203345658,0.08049252217774455,-0.005802128828059944,0.10038604389730278,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01824224147340315,0.04915733092796059,0.6389496410469363,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0556110624424624,0.03015043519573747,0.0668781254554361,-0.003911480227323051,0.11513360511224785,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04553327286207449,0.07507744072820127,0.5974084401217474,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05112448051825952,0.024217958584970972,0.03625089930637499,0.0033137453202207803,0.09893521571629826,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.035626383385456074,0.03482612240845559,0.45679694638302454,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027702539465775118,0.029830775634360256,0.35439955068422924,-0.031188936031733824,0.08659401496328406,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0370243568050921,0.04260723096054261,0.9094475823584263,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08636569492450848,0.037394032691633806,0.022126564811215922,0.012542949347761484,0.16018844050125547,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.036415779390101266,0.09134018053945879,0.34668618042031035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05266367186175975,0.032136034860663666,0.10313190486141895,-0.01077881226205122,0.11610615598557072,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0580365973762895,0.022957890603774008,0.6839484127328216,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0438442781812996,0.02834458035609345,0.1237856598211501,-0.012113172606716065,0.09980172896931527,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.034504466843343434,0.04255689563934123,0.7255813269452924,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07039521503133657,0.031932138768849296,0.028846319862121217,0.0073552595525164105,0.13343517051015674,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.07442389033652265,0.05938641112774028,0.4046097093301284,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04242941750086695,0.029973419759699672,0.15875313086117804,-0.016743663916489876,0.10160249891822377,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.02190027523110968,0.040971420482348836,0.7804909419375794,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04773047609412445,0.028700411953777177,0.0981650844271068,-0.008929452164577335,0.10439040435282623,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.020204740901694548,0.056648954198612794,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05698475001011893,0.028133248915556373,0.04439552632837039,0.0014445066224333877,0.11252499339780447,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04249193159604222,0.057134232238998016,0.5034452685637203,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02812458638644101,0.043509539601143093,0.5189021099609903,-0.057771302367360236,0.11402047514024226,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.039171350888505214,0.10365581627281713,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06978589301475754,0.03517389371298107,0.04888179799485022,0.0003461129319346362,0.13922567309758044,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.06820247986293583,-0.005114580406953241,0.5231588877093131,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1259979453158783,0.18499408020722352,0.4975817353029488,-0.49357724222238797,0.24158135159063135,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06880091429239364,0.13901802830663648,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11555205626240837,0.1804324903701839,0.5235468825687253,-0.47406757132683597,0.2429634588020192,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.07774364668487871,0.07560003848770104,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033985655390897936,0.11516784411474433,0.7686072801718926,-0.19485039773315888,0.26282170851495473,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03041118863648724,0.10734608963079265,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2231157617685641,0.1903267700812413,0.24421409682468623,-0.6012909998658199,0.1550594763286917,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0003989617334481464,0.17407386381532994,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00017122875015466025,0.14497017197882503,0.9990602375472089,-0.28822387253584236,0.287881415035533,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02225162326207835,0.16430030742323642,0.9996899238181953,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01675199815231401,0.10917413919229098,0.8783963822165389,-0.20017469095970203,0.23367868726433005,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012768280031735225,0.0632054830503486,0.986191362849829,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12692610770614343,0.17294788586025564,0.46493990271553365,-0.47056987303511494,0.21671765762282807,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03402381519742501,0.10683546512836892,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03906319441719934,0.10665447379605456,0.7150408080667887,-0.17285697322261184,0.25098336205701055,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.033058272160767045,0.1217609296172673,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040334861999312376,0.13797523884183097,0.7707116208936851,-0.31448872263732214,0.2338189986386974,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.008520840368722964,0.06485872905616896,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16262192179958207,0.19745914003154785,0.4123839655627306,-0.5549690270650957,0.22972518346593152,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03214630403215349,0.16294362197012502,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061060667461975186,0.12351404185307926,0.6222684888296595,-0.306480437713971,0.1843591027900206,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06615434009394489,0.19733838965482747,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.22411886006851084,0.17442332829395693,0.20215659113794435,-0.5706942980855945,0.12245657794857284,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.02998720025024335,0.07278537503406342,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08355417011869369,0.14272132871120033,0.5597362705809525,-0.36713841023308297,0.20003006999569556,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.022554272967220654,0.160213181255195,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022397253063119175,0.14081557566981975,0.8739868637625127,-0.3021948024777659,0.25740029635152756,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012470445200963099,0.12324500614813723,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07873863896184415,0.23918320812030586,0.742779459751056,-0.39651330085278136,0.5539905787764696,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.1051696088527,-0.07518159507655561,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16852306078509793,0.14888055029194808,0.2607024956759883,-0.12729942141577655,0.4643455429859724,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12697514382737343,-0.086973056752792,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04562658777287492,0.11884273503101463,0.7019504043818853,-0.2817645708705699,0.19051139532482006,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.056791088014925724,0.011420455063883967,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060740752348048245,0.1418170699388611,0.6694648991017254,-0.3425282495429578,0.2210467448468613,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.057413306767561775,0.21735248918331423,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05572533355253082,0.1367526188933147,0.6846265866451018,-0.32744987439524736,0.2159992072901857,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.007959982542654979,0.12753544836109312,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054008416025378446,0.12890546350885992,0.6762424432266063,-0.3101408262674673,0.20212399421671043,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.042684540884394,0.16889195597104983,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003367958187228598,0.2199980094382331,0.9878198974644288,-0.4404993168747796,0.43376340050032236,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.08500525629959611,0.18081115415515742,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12013909109639413,0.15518834582628238,0.44089361795639537,-0.4284950286648317,0.1882168464720434,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.009353833110319633,0.14408002029258044,0.9320838159679753,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04114634525768989,0.12061903942765449,0.733812406281914,-0.19852111683996787,0.28081380735534767,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0891961585877037,0.03781296689808815,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.23971190996239555,0.1867855310970796,0.2026997740023105,-0.6108507816282608,0.13142696170346968,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.019216574413819007,0.02185631415908266,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05393522264786692,0.16367360602634806,0.7425300594761575,-0.3791511914936034,0.2712807461978695,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012742210824478633,0.10867038729287193,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04687400794075379,0.10634926184321805,0.6604588660408535,-0.16443971004993657,0.2581877259314441,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08649016108878134,0.27078099183612714,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017439085679995123,0.13439655241080356,0.8970503686923141,-0.2844821726073413,0.24960400124735105,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.07967120404530324,0.03996642607302691,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06239751802841704,0.09312056512700546,0.5045465711969708,-0.12263106136493024,0.2474260974217643,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.16380807654330148,0.32791141095626275,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00794603747495716,0.1675275079644248,0.9622758037293375,-0.34081962738163807,0.3249275524317238,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03615480936613008,0.12879379118281284,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0503019726643411,0.1085448977151213,0.6441940236833629,-0.2659783723643751,0.1653744270356929,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07903497602263687,0.1804499841792256,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03623206123662941,0.12439992819295087,0.7715342570428092,-0.2834120687761337,0.21094794630287483,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.010077764640726291,0.12998900175199526,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09649720784636595,0.1887075563137824,0.6103663975701096,-0.47145510267773355,0.27846068698500165,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10462507429896267,0.07471049736897986,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1961997954168615,0.159045133108999,0.22059592446423196,-0.5122190871645838,0.1198194963308607,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04265357338829206,0.023906446028946905,0.8354439162199777,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012667101303326784,0.14692686208661115,0.9314902414787866,-0.3046076466547201,0.2792734440480666,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0036280896422349884,0.12493559747549492,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09683625000083355,0.2088306355043206,0.6439897124069044,-0.5117782745522786,0.31810577455061156,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.09261465508469519,0.076000794886664,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045583650007204705,0.14954346289551051,0.7612158764700054,-0.25155602541658256,0.342723325430992,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.18780573944835757,0.24283128161648757,0.9680441569078666,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05906253741964086,0.16538511918798718,0.721846443209058,-0.3876792464614789,0.2695541716221972,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.009430934629945507,0.06988869828784701,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07088477650498078,0.09383141811212882,0.45197478903040156,-0.11555625262828705,0.2573258056382486,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.3322791723006225,0.3179942699278072,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027031002370493808,0.09868531490778745,0.7847876540319806,-0.16905461630534951,0.22311662104633712,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04296733518336648,0.04959828519132685,0.9721878388985049,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0052511438045314916,0.0998461887082165,0.9581745942703954,-0.19314110638557927,0.20364339399464224,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.011644342071577662,0.11613480228016945,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05133079233763807,0.11958273673019822,0.6687792188827921,-0.18627755837393317,0.2889391430492093,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04960870062857282,0.09558632460424477,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05778510467973851,0.09984076434245219,0.5642044592137302,-0.2561665767706172,0.1405963674111402,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.013075316632703882,0.0705881006871217,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014735965483367443,0.11806113557007418,0.9009503992096302,-0.21984899613389328,0.24932092710062817,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.015040788492321423,0.0980453432323715,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007889880376283602,0.12279566475215911,0.948913581711271,-0.23610248987797078,0.251882250630538,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.012224182421593628,0.13606429469898296,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04057275525395164,0.10551578316703818,0.7015115539438906,-0.1690848583606766,0.2502303688685799,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.027398779026163687,0.13997534068402534,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007967027133299559,0.12235319972946036,0.9482284854876203,-0.23514617454557585,0.25108022881217495,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.015388730383658188,0.09221584461942764,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020367843683866783,0.16208553914477103,0.9002836389403468,-0.3424283574625183,0.30169267009478473,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.032707855566359696,0.08553683001730131,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015485085470615093,0.09133054589377236,0.8657489102174081,-0.16598676383459143,0.1969569347758216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01773027289834427,0.0444458451123485,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045175378179503574,0.10228789618740905,0.6598142084666203,-0.15806849276218796,0.2484192491211951,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.020899493362804465,0.056659825131092335,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014831067840738933,0.13760471557750067,0.914412630511838,-0.258586570963375,0.2882487066448529,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.006162944475070694,0.15189036244607912,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07204275555616821,0.07126965018974926,0.31482968609039297,-0.06956852129212734,0.21365403240446376,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.20182598935605833,-0.0962694064477612,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050158871454846654,0.09068587730881623,0.5815777720689359,-0.1300320351038112,0.2303497780135045,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.20508100611087154,0.25831756965149755,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03407075315057603,0.17806404042879273,0.84869515342768,-0.38788020863061246,0.31973870232946044,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12382028268517913,0.10154300843712809,0.9827611894425448,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06103878358094403,0.243534849613044,0.8026726688519901,-0.42285977518763984,0.544937342349528,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.17201173581370666,0.3466577597535442,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034684334122250096,0.1664244754059773,0.8353859573060045,-0.3653662218304339,0.2959975535859337,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.033391171490676205,0.18000414752365765,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021714288334011546,0.18028842516119667,0.9044045531245151,-0.3799435488968416,0.3365149722288185,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.015434167845637775,0.22299460083101746,0.988603595072994,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052320243565332596,0.13982387426888757,0.7091553765677818,-0.33014730342005655,0.22550681628939134,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06558273449385783,0.023485907626485555,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17294019145998904,0.24723167065327514,0.48605972256478025,-0.6641842548913989,0.31830387197142074,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.1010653326144649,0.2646422926851143,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11299803750691778,0.141449395093776,0.42649924694994457,-0.3940549726162989,0.16805889760246334,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04804083128727381,0.03150743090252696,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05300825136663663,0.16211385816894286,0.7444495755547227,-0.3751250344431084,0.2691085317098352,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01952398802849892,0.1423871704717342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0648708918436478,0.09420723244787514,0.4928675068324234,-0.12231687236971706,0.25205865605701266,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0259479151451548,0.08043787939642827,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07063689858521653,0.12405076761537558,0.5705060257307899,-0.3171231314943714,0.1758493343239383,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.09341146276219185,-0.0058007614232431365,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039160376059483804,0.14403725104088516,0.7863465006530437,-0.3253593258131615,0.2470385736941939,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06772008579137605,0.04469940681991056,0.9723925976809099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09680941397423908,0.22470711860910575,0.6676373363738374,-0.5432976722779637,0.3496788443294855,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.007147122340316978,0.17554551039502486,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007320738017456259,0.14709337672250763,0.9604177357920864,-0.28495066836861943,0.29959214440353193,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01749634216309244,0.05027590828510024,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02027145786993702,0.13055329844637983,0.8769573812720297,-0.2796780810331802,0.23913516529330617,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.005774153506515293,0.10876219998321598,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01902837024911489,0.18387943493103284,0.9178125786629414,-0.38439289073432836,0.34633615023609854,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03860389951287801,0.08540404950580065,0.9901412236863718,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024356983205649555,0.10117689533454712,0.8103129526200105,-0.176679352706272,0.2253933191175711,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.12403834850233432,0.21234008691220924,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06151215093237865,0.12840483973470346,0.6330790294304529,-0.19362553053399484,0.31664983239875216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.011351377704749433,0.11616529540838931,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007402390991282722,0.08225446422390012,0.9284943698975501,-0.15603547736090825,0.17084025934347372,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.009310529120670173,0.07608774638038815,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003312937934933034,0.10762229424876796,0.9755115184040888,-0.21053026832936622,0.2171561441992323,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08091544839331691,0.18025637794252325,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012825423841409677,0.13627747271339358,0.9252312856276725,-0.2836058593454711,0.2579550116626518,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07523733374447635,0.1675605356447373,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000934508361144892,0.11009369497946245,0.9932463954312238,-0.21781931851298858,0.21968833523527836,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.014693226902019548,0.10462081393750275,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18219016768026816,0.1754341718727919,0.301845838466627,-0.5307741303570296,0.1663937949964933,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.061180902553067545,0.15268796443654123,0.8900639917340583,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022039904225106467,0.10033292015775135,0.8266329849821313,-0.17731947098760983,0.22139927943782275,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.008994939779012105,0.05739569585966422,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18892506002155188,0.14963683461609348,0.2100465151173045,-0.48625026306527375,0.10840014302217002,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012215318852102548,0.06720075346240707,0.8250119925785071,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04527297087822049,0.11791370811572159,0.7019312450457624,-0.2795649972839602,0.18901905552751921,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0069812826933754206,0.04687170338939118,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05376144658438288,0.11038080830681812,0.6274172832856995,-0.27308576152431646,0.16556286835555067,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04042062206721172,0.14495671934132387,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009957531620330464,0.11506242421142975,0.931231358457324,-0.21866905440133622,0.23858411764199716,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03549575068896218,0.08481378703010242,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011720600292573814,0.1289055811758024,0.992765771173012,-0.25496058401453975,0.25730470407305456,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0009988751702519364,0.10090620515246507,0.999521629637202,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06162546563890389,0.1272378726515536,0.6293395230518831,-0.31444440836803367,0.19119347709022586,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02566010794876248,0.1609806585992016,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02224909589061136,0.08947872885735889,0.8042025933519988,-0.15554323240785875,0.20004142418908147,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05659444368341042,-0.037350195273459376,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015903089894911487,0.12958862802543994,0.9026056828247866,-0.2733929334797034,0.2415867536898804,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0018434675678515708,0.11983305408160475,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006825944260124229,0.09323173672253542,0.9417994736904383,-0.1784235307255312,0.19207541924577964,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.017247689130748776,0.014032370263056631,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0483980933185717,0.11189994058566213,0.6664153798870527,-0.17394470510115737,0.27074089173830074,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01891966507977359,0.18096573673778416,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048214511645971875,0.13129359339705593,0.7143216855459552,-0.21266306181561676,0.3090920851075605,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0714172177288459,0.20996570396107422,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05330530615015735,0.2316845918244242,0.8185598944857677,-0.5136576551090953,0.4070470428087806,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.08130534147289929,0.06474784921306302,0.9782788982878687,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08582984987481199,0.18192087805368987,0.638225845350618,-0.4473027595629734,0.27564305981334947,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04034368226193161,0.20467115807907676,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04251703261410027,0.16326373871791833,0.7951419046119057,-0.3669186038483629,0.28188453862016233,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0203008465933069,0.17913808389276129,0.9735235918682278,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03393051445059297,0.0827211276731315,0.6826599704954397,-0.19829563313624485,0.1304346042350589,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03969749095654931,-0.00867555166141737,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09661087288282356,0.18206754642253298,0.5969953898259461,-0.4583752094957676,0.2651534637301205,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05590280572143156,0.12056893974580633,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042091804383735616,0.13904687983566993,0.762812202231133,-0.3183749928500212,0.23419138408254997,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.00851055874790444,0.08958902941958895,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041193210985358164,0.14330211179648863,0.774430592900786,-0.32593145471924884,0.2435450327485325,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.002274653020090908,0.17928584694459185,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09719189254146783,0.16065535134326706,0.5467374142211774,-0.2220268685393016,0.4164106536222372,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.05194484170792466,0.2504467090306285,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09540361524189545,0.17873547695694145,0.5948313979562296,-0.45054720080143384,0.25973997031764295,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02744830258977056,0.20643113329195187,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11169958101393763,0.06160613887828812,0.07318365438901928,-0.010710504696046633,0.23410966672392192,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.17831015004569878,0.2580259948495923,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001702227177012953,0.12429711921227896,0.9891041055378986,-0.24867795546180418,0.24527350110777826,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.035771262076255736,0.1070766961474487,0.999046747647263,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03181666983299231,0.16967807699196483,0.8516860750250774,-0.3689633945892132,0.30533005492322857,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.023899725721780306,0.19039078528061862,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10825957083483746,0.17863040719587325,0.5460219060179508,-0.4631943850171711,0.2466752433474962,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.019119425335318373,0.12854582545971893,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04706067876639246,0.08896099336096086,0.5981199150255387,-0.12970292012875645,0.2238242776615414,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07432390384042264,0.14372691534401963,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06750776456483816,0.11229911046950927,0.5492731330804823,-0.15562817591157957,0.29064370504125586,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04606495611924086,0.16959590493478072,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054961721382920416,0.11195750343809431,0.6246942274863735,-0.16749545319847423,0.27741889596431507,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.02559223729057494,0.09209286882869545,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14521181605744818,0.11958090204683404,0.2278303745220148,-0.0923928891773581,0.38281652129225446,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.006129638523708999,0.14644844987924147,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043373403034735414,0.10480306511801835,0.6799750158279099,-0.16486805499773677,0.2516148610672076,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10030456239680846,-0.030922738317429428,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061757502238001666,0.11501010714485185,0.5926250865817162,-0.1667651308867541,0.29028013536275743,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02557951374645911,0.14925428503291696,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041255615801121394,0.08768322838387757,0.639143527338299,-0.1329690913015879,0.21548032290383068,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03069698513355944,0.07355175278888132,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1428561685513983,0.11470747561156272,0.21625531976657747,-0.08506514216291305,0.37077747926570964,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02787237349080994,0.12043674179264563,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0567841166136053,0.08285656613541259,0.4949166781307549,-0.10785011541169298,0.22141834863890358,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.061043873162746204,0.0525673417507669,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006459340660858698,0.09010664208738449,0.9430130333508522,-0.18549931917252788,0.17258063785081046,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05283784471860476,-0.03660058492138753,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027500471948071977,0.07552641728333086,0.716634073802108,-0.12256891044392948,0.17756985434007344,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03899323979500098,-0.02601447261021126,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06830483361841083,0.1261595862589211,0.5895735537855338,-0.18237157701659068,0.31898124425341234,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.031332526028500736,0.1440564894021493,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03798679051613569,0.1280932745887516,0.7674966853724217,-0.29250539867399433,0.21653181764172297,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.002434774735771407,0.108433842208097,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05459493903301115,0.1684192197586564,0.7465767628761311,-0.28005046321490645,0.38924034128092877,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.033123355201433294,0.27540430495656604,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13171943199155842,0.20464274358195864,0.5214540072481731,-0.5383402044974359,0.27490134051431914,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.050893845594086454,0.1341740679445958,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07819223723625568,0.09843860182030865,0.42911925547734897,-0.11740316778987783,0.27378764226238916,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.014657646515887544,0.10138128983155681,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08240214518932755,0.14749641913690853,0.577788411195822,-0.3754743882678154,0.2106700978891603,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.03288199073588377,0.13354935006979124,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02725766216589101,0.13905277599586605,0.8450383729379105,-0.24903724184511314,0.3035525661768952,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0314312206373256,0.15817548777320184,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.079906485664695,0.15198571713330974,0.6003694901320897,-0.3818988682377683,0.22208589690837832,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02036706686419848,0.15943073351799014,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011019609726060812,0.14587085993874244,0.9399517600913625,-0.3008619013030061,0.2788226818508845,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0381728734330019,0.08528974274259352,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06612375566521361,0.14990340951929468,0.6602037544383019,-0.36397863736341923,0.231731126032992,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.009775151755725749,0.09482971791387713,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06262176543915565,0.1148083013482314,0.5868110300311605,-0.1654998838662784,0.2907434147445897,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.019589164558172837,0.12992331802686635,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1320386100389752,0.23079442632088945,0.56869321596739,-0.5906222191033543,0.3265449990254039,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.008704140456683634,0.15882738026691684,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06770897095370275,0.1746133009323964,0.6991156210505274,-0.41466188055685466,0.27924393864944913,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.10030218729021287,0.23043773257849276,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18838071507263557,0.1680617348910261,0.26534506516844303,-0.522315802503176,0.14555437235790483,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06915674960850902,-0.018226326279955865,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006610636092265638,0.15915428798725734,0.9669616157102114,-0.32284681625803435,0.30962554407350307,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.034280114095822094,0.18924429720874802,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16231814563612726,0.16741962914791308,0.3349088947698481,-0.4949773826322714,0.17034109136001693,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07321904363384289,0.12744224047663705,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019339920740471542,0.14411362597516442,0.893548135655128,-0.2670107843807953,0.30569062586173834,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.023332897753720997,0.15433776704715202,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052532913889632465,0.091002874599388,0.5652168622434539,-0.12828785953319266,0.2333536873124576,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06475374876075422,0.01569079181891101,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0011840861965473053,0.08090613868293904,0.9883558893186336,-0.16194286041884834,0.15957468802575372,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.042734338556489455,-0.006199875875143668,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007533049585559912,0.10235482365031488,0.9414958933179427,-0.1958438047993375,0.21090990397045734,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03365154768028991,0.10387268128148733,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1632753336601071,0.182243337284453,0.3727126762089451,-0.525388962971254,0.19883829565103983,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.035368233201975394,0.20498493361073064,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05259164082932805,0.06052513782015268,0.3872268643673473,-0.06767051880399735,0.17285380046265345,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10715095675292337,-0.0791334673757973,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08612795501630761,0.09921434587187161,0.3876744752833202,-0.11100883691655021,0.2832647469491654,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.03577879320360579,0.12562656972763242,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046263126086582944,0.11443799335502636,0.6869886614007854,-0.2736489812972616,0.18112272912409574,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.039153434259072445,0.1557487648198988,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049256426704467116,0.11671727752468246,0.6740318424959562,-0.1826583176014401,0.28117117101037437,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.024906681744851274,0.08875306166761292,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06926369544080721,0.103935999048683,0.5068747015740449,-0.27578231166244543,0.137254920780831,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07513583990566045,0.1429323907792652,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03489753282842541,0.07713878964376696,0.6520821545010673,-0.11837559909943525,0.18817066475628608,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.013831764712340183,0.09368836880515655,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042113886530259194,0.12208600268796513,0.7309438681548508,-0.2004684003185941,0.28469617337911246,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.01934200025496992,0.14007689015181982,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11911037502913327,0.1976149205658081,0.5482145885221015,-0.5117670128980196,0.27354626283975314,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.00963631793002148,0.18187405531775497,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06141262735946377,0.19044737345040547,0.7478566741215394,-0.4398275017823375,0.3170022470634099,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.029210786905475662,0.10992385534953782,0.9635753025013546,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03070919312934658,0.08774003912795028,0.7271640877504078,-0.14362839571173827,0.20504678197043144,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.017214818968613658,0.08282131752102066,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10495632150542503,0.21070344591132828,0.6196257492007944,-0.5236195804438081,0.3137069374329581,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06242655910485705,0.14980083049570356,0.9576692362063679,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054656457586924216,0.11647679220344415,0.6400401807367125,-0.286093362681987,0.17678044750813857,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.011029599678990209,0.13710357813339877,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004447118616880831,0.13436119667247048,0.9736703655302297,-0.2714199544452539,0.2625257172114922,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04203913370012932,0.07604842824951258,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06281658077399721,0.17343022234715877,0.7180605364316164,-0.4074187384284399,0.2817855768804455,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08725663807870859,0.2492188700742172,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08611035951298027,0.13808176721188298,0.5344731274373665,-0.36047588975317657,0.188255170727216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.18361457811990806,-0.0381319535961399,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11272550747156738,0.18403519789421127,0.5417547011085513,-0.4783995256467884,0.2529485107036536,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.08019829139948186,-0.023978128130880603,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0739877602548005,0.18577811272777733,0.6913932389754542,-0.44312491307937074,0.2951493925697698,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.017723844626968233,0.16133148344980044,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11177343482986855,0.17220134742995152,0.5179544957347773,-0.4539338441994629,0.2303869745397258,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.022510482343407343,0.13856843097330032,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029681932713821416,0.12255940088317989,0.8091947445377884,-0.27320485169295117,0.2138409862653083,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10587442940753398,0.06713073927198054,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19421213483196106,0.19806198025467758,0.32946659664279043,-0.19933280111611693,0.587757070780039,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.5384547620831803,0.664719215302393,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0038232658246355935,0.1523708525875473,0.9800378794496172,-0.2989343726924324,0.3065809043417036,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06954191110235164,0.24652522041792485,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005724883024847922,0.14580325029601293,0.968767500812882,-0.2839830696321126,0.29543283568180845,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06579504912689521,0.21709007300997696,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020474081150738645,0.1306993969874567,0.8758753768138969,-0.2392228367016532,0.28017099900313047,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10040208729355066,0.01873270847786331,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07193117190008276,0.13466006344357873,0.5945567185976484,-0.1956355058364726,0.3394978496366381,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0320873612234387,0.21200701082836101,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015657671674333202,0.13444125801101842,0.9075465980487045,-0.25147424432838855,0.2827895876770549,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12366135647160799,0.021815664551410343,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0047260821694224105,0.151150220135693,0.975126260145049,-0.30505835000472975,0.295606185665885,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10176564782287967,0.020038130512177208,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029985815221128875,0.14191523769162198,0.833141063648693,-0.31196836964975266,0.25199673920749494,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.042273157480846715,0.15025417748067135,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016901722839479206,0.0938448041132889,0.8574812208017354,-0.16956590399296526,0.2033693496719237,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03169822404306249,0.0039403528603235895,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0064570217283557935,0.13239270767492672,0.9612104927853189,-0.2566044683916854,0.2695185118483969,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02746800847052291,0.18145525690283223,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04884669073824161,0.10999367604850344,0.6580580483369153,-0.26740178212701216,0.16970840065052892,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.057512869289949496,-0.023256609213870426,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11945014672194437,0.2093216618789601,0.5696725302174219,-0.5353678302206939,0.2964675367768052,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0144849432649532,0.2129643851521584,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03457003127531087,0.13645723764589182,0.8005900285144777,-0.30570765587116455,0.23656759332054278,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05751342965780381,0.06833283061402436,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1651380629435319,0.14270828873285632,0.2502983357655175,-0.4486963928987096,0.11842026701164582,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0739511783997,-0.024298839414673826,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10753117235518588,0.1613858388588566,0.5069437007162769,-0.42820139656968703,0.21313905185931525,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.013192639906126897,0.1589125210023679,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021778478779796148,0.1223368600674078,0.859111385362976,-0.22130225633862366,0.264859213898216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04527213759622206,0.18794884468252895,0.9839478606341621,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1458049713609465,0.13203340681281187,0.2724381168467392,-0.40815253832125115,0.11654259559935815,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.1283161266356453,-0.14177790343436153,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09681205699172547,0.21005039949229493,0.6459952512680507,-0.5141777266057005,0.3205536126222495,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0736048426817416,0.10004811602753383,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053269100861085036,0.11056837304108552,0.6311482254315531,-0.1664279012106164,0.2729661029327865,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.014891729154761583,0.06686505273724404,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012705818437992381,0.11097578845478348,0.909105840526859,-0.20780070938257747,0.23321234625856221,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07516068554695368,0.09328009663544837,0.9888301126476031,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10418006156830727,0.05533848069852993,0.06302197251686058,-0.005776320842711166,0.21413644397932569,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06435668848082128,0.0107207394214319,0.5817074626033015,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031711690449391046,0.10143599489177985,0.7552949663758508,-0.23326285166258554,0.16983947076380346,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07109008154962429,0.06906325011033856,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023363897302848474,0.06926655834351284,0.7366818304291001,-0.1142672787138206,0.16099507331951754,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12572625455916364,-0.11917735152270423,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014210096703145344,0.10236214642291767,0.8899046083255088,-0.18918130787493512,0.21760150128122582,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.05286144079009655,0.10639039435798363,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06897650897525175,0.07340971968061845,0.3499607902776789,-0.07688704036686415,0.21484005831736763,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.02607175052614016,0.02408246888025683,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02202965303909578,0.10482679393736515,0.8340287103137207,-0.18625895365198292,0.2303182597301745,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.021698871758071173,0.0704000422238299,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03136194083601333,0.07829192530027726,0.6896915909506232,-0.12420244707897447,0.18692632875100113,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.008207326569311453,0.03075336588882326,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008188954561849027,0.11513251071131259,0.9434567869651092,-0.23695480096590588,0.2205768918422078,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.006647648937914552,0.06892792942962374,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08599810626954715,0.06959026745021143,0.21979303817342333,-0.05227627284696823,0.22427248538606254,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.046008113447224684,0.08506513438310301,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.000619577407995921,0.10883369406458773,0.9954705028605509,-0.2168698093029149,0.21563065448692306,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08338227660573286,0.11221664398975495,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1329821725231079,0.08248311489001778,0.11045147587052019,-0.030910019832286778,0.2968743648785026,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.11327765148231617,-0.0533878009489832,0.7002905874282662,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0696340018464753,0.09552794756170128,0.4679531425694583,-0.12017799516617812,0.2594459988591287,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.026061391609350604,0.09941577658782752,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04447693134080434,0.11011818089058766,0.6872538059491263,-0.1743255485171729,0.2632794111987816,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.003814666422052029,0.05911322467063462,0.9631797688191589,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008655704174229032,0.10209490979140701,0.9326259545768505,-0.19420470690931194,0.21151611525777,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.007520228334348125,0.07597801255668965,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037399946162911056,0.08268091454182802,0.6521241568445013,-0.12688526988740034,0.20168516221322247,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.004577956485452771,0.02518493546344116,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08067128016020385,0.09831551018683746,0.4141037060695957,-0.11467954441213497,0.2760221047325427,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.006693373500822112,0.12310868522520362,0.9264811777847943,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010819560284461957,0.10907216643150493,0.9921076083541533,-0.21564211537995812,0.21780602743685049,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03940228880413824,0.03664588743281163,0.9994099232379783,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05157913963231443,0.14023723920606618,0.7138962422204362,-0.22706926754770618,0.330227546812335,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.24401110047896857,0.39713014374828204,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08161418489068718,0.13751720340602153,0.5543629730535184,-0.1916295690927502,0.35485793887412453,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.09543771204367185,-0.07407341445163304,0.9491210479105492,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08216955229395108,0.09649820368470961,0.3950259856356886,-0.271913316827028,0.10757421223912587,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12356042446088032,0.05960655382751339,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044244256568336936,0.10130816679204856,0.6625582802734755,-0.24344581899197007,0.15495730585529618,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05156089179617044,0.009106102711439206,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017284898589128014,0.05056833378470329,0.7326828122640072,-0.11671707092079948,0.08214727374254345,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.036820051952357026,0.022592007914204137,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05536162401247173,0.1027251554317244,0.5902543913987544,-0.14662615357917808,0.2573494016041215,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1357012485088872,0.2098954136232945,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01880711780462863,0.07779429725944687,0.8091022261933116,-0.13415928216527667,0.17177351777453392,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.14581621407472475,0.1462523382886521,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12668253014104755,0.0684668232412314,0.06505806082991963,-0.26130838110360277,0.007943320821507671,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06709513372326031,-0.05710019401319723,0.5895329758766005,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14106431586329812,0.083128566886417,0.09053527786843314,-0.30451945408332426,0.022390822356728013,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11852749926253221,-0.02018560039686049,0.6632964530955446,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03377092039475304,0.060636928051800223,0.5779021422796164,-0.15300090146115689,0.08545906067165082,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13867028604804493,0.08637767555566853,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013873007862615905,0.052895205740766255,0.7932542640782096,-0.11788049276665798,0.09013447704142617,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08325937536977684,0.05923054027260643,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012776928274663856,0.10415558846608129,0.9024327277797048,-0.21757735665656205,0.19202350010723432,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12238378953372114,0.11538892505768004,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01709664399052231,0.062364517669541514,0.7841271465142967,-0.13972357282508896,0.10553028484404432,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11305362742969383,0.11266720665920647,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029680363025789788,0.10750846269735637,0.7826423930407725,-0.24107352530692927,0.18171279925534972,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12120891982837953,0.09186333081866893,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028096172285183147,0.08394493135634563,0.7380397922791597,-0.13696417786460507,0.1931565224349714,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10245218744691026,0.1364051099396029,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0077789435321370115,0.06310287042377552,0.9019559921647653,-0.13185769038809886,0.11629980332382482,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09766817975191361,0.07580291236158868,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2169282256459882,0.08287824561980821,0.009217050456155536,-0.3798911588543622,-0.05396529243761419,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.014678961532622159,-0.2343013362386059,0.1972100984392524,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048920431582092305,0.105438311764158,0.6429362537458527,-0.2562430700999075,0.15840220693572288,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.01040993564634277,-0.08029950108601773,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05129856755601015,0.059344132816763304,0.387905447647506,-0.16798653410504744,0.06538939899302712,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04264530878336423,-0.027313649560684546,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02420109060496283,0.05728494161719675,0.6729244777829293,-0.08843790223078396,0.1368400834407096,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12563596934229235,0.16599009535987475,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007774671481517197,0.06903915150332586,0.9103978710161202,-0.1435258876306959,0.1279765446676615,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07399225866431325,0.06604508106991273,0.9891749114349121,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011080802315169443,0.05743903375652424,0.8471303625518551,-0.10186118085080653,0.12402278548114543,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08047596205553431,0.10789687877467949,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03061183960421504,0.09345327758022706,0.7434243752884749,-0.21436838655470083,0.15314470734627075,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05665437722623677,0.024697678684643454,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0550757515846839,0.07558862985719861,0.4666847520544225,-0.20370516267572997,0.09355365950636219,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09761752681669457,0.06363125751629758,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014161768003245504,0.06594071647865084,0.8300668558839048,-0.14382055234235797,0.11549701633586695,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.021373691090360598,-0.042458854827685084,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009509229386745064,0.08755312351998072,0.9135689984027651,-0.1626458845839717,0.18166434335746182,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1232980940725214,0.12914594515900213,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034785138539439396,0.06088066088827312,0.5680929491753379,-0.08492409275304943,0.15449436983192824,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07553868501172747,0.10752374386475605,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021724075303473412,0.05808387279525388,0.7086060767851112,-0.1359340011052131,0.09248585049826626,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.14446077660970266,0.12774496735236593,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006787832040327128,0.059195439338071414,0.908769360794768,-0.10960775952833537,0.12318342360898962,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.022166401353097283,0.027668498265134834,0.9888301126476031,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020736365568796353,0.05286365584915106,0.6950874192771964,-0.08320908299698146,0.12468181413457416,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.16809351836084901,0.20230549954462335,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04557022344682676,0.06650901141415341,0.4936565122171369,-0.17634644226979404,0.08520599537614051,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06834512137939394,0.02434682408939192,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011119002925626856,0.05494663338986675,0.839744713030937,-0.09692219027498991,0.11916019612624362,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13122131321142375,0.14559320407339268,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015041367830676125,0.06041284087963803,0.8035150288249714,-0.13383072780771182,0.10374799214635959,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10453961830409528,0.07618038272589442,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14171707685763105,0.07874754404157334,0.07271937310912772,-0.29655783952096726,0.013123685805705193,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0653538160206238,-0.08168907817240204,0.6233762243415291,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08131198679472719,0.08641793206987322,0.34735217140227737,-0.2512349815032769,0.08861100791382252,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09275472298989296,0.010503613445529402,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03651824449136876,0.06837343622381678,0.5935880582366321,-0.17096046919388846,0.09792398021115095,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04417011892980904,0.008541824002644733,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01635468304107992,0.0900075694762043,0.855913397260166,-0.1606265913947424,0.19333595747690224,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0729702896594442,0.08615388731211945,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015564310554521623,0.06054315791761371,0.7972592237696656,-0.10348129093193219,0.13460991204097544,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13625171542106437,0.14846801326915052,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010656025213819385,0.06491368648553972,0.8696958884729133,-0.11698331700367604,0.13829536743131482,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10202979422746235,0.10341064804366056,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07080189410661114,0.05855198588419061,0.22734034773166745,-0.04432847929239439,0.18593226750561667,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.18190916083206787,0.25423923677879806,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0005179879508613003,0.04739534554075201,0.9912858185803743,-0.09267515908046761,0.09371113498219022,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0606653337581169,0.047063787891795376,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027174644494348716,0.05030540103095063,0.58938348647896,-0.12608981393258722,0.0717405249438898,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10444346634155706,0.05957273725502108,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0060917808968481875,0.048059526915919644,0.8992021416409782,-0.08840734147541893,0.1005909032691153,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05654881131532343,0.05046618076213815,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008821457949999046,0.05358798870587132,0.8693344379612553,-0.11419115730761702,0.09654824140761893,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08339307047748848,0.062224132808931264,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037331947780884354,0.0550172401285436,0.49784044532144467,-0.14551197453369574,0.07084807897192705,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.073059563801862,0.02414770870226468,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02718068906126937,0.04793269483573246,0.5710121394332348,-0.12143042237302187,0.06706904425048313,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12491906385448534,0.07768108591747987,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015062564935758296,0.032412719563385414,0.6424070242923505,-0.07879547595248595,0.048670346080969366,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06178480363694759,0.04405040392878175,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07989448481460974,0.04456069326249693,0.0737867485595161,-0.1675138742641319,0.007724904634912419,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06579659625755788,-0.027963994793212398,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009829656136142857,0.06256122117500702,0.8752341438226142,-0.1328433617416619,0.11318404946937617,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07639274972771597,0.04940187791729748,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05660652299231069,0.03970247577775453,0.15476495193192044,-0.13467323229571004,0.021460186311088668,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03735165129655414,-0.03054050171289719,0.7731429757303867,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0030486594254214494,0.028401646513543568,0.9145757582225065,-0.05889462466250703,0.05279730581166413,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0643341023598448,0.03665883199760039,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048543850780314014,0.05409438799596837,0.3700842129153572,-0.15490927963331033,0.057821578072682296,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09193112914663003,0.03988758024523069,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07198927248135419,0.04233057541681881,0.08983655390396306,-0.15522359631065058,0.011245051347942223,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.0929032403569804,-0.18725089325721117,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024785237679531127,0.04802305044111216,0.6060800654863439,-0.11921263660636,0.06964216124729775,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.21270903848459358,0.17699185876790208,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08927048484087878,0.08976219446680944,0.32060833881432294,-0.26576928005711853,0.08722831037536095,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.046074102575376155,-0.03661845005813203,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08480862538001674,0.0745176417074288,0.2558028422857643,-0.06171490896360718,0.23133215972364066,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11907457195684353,0.22789362409547304,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018512047592009234,0.05355333076272381,0.72978029370106,-0.12381359927067903,0.08678950408666056,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12487686691709227,0.10629899805851462,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05046931279703825,0.09369296138904584,0.5904353606676791,-0.1337585228038715,0.234697148397948,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.17388033694390453,0.20572727879642413,0.953198269875948,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062041264571692636,0.06908872270320936,0.3697633530941601,-0.1978899522355645,0.0738074230921792,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08519740997518234,0.006096428358371028,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07669752283984438,0.07691048669617559,0.3192937175799554,-0.07453104640362468,0.22792609208331344,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.14713152084114547,0.2566014848063021,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02759522556402511,0.06769596889371551,0.6837738824981725,-0.16070535084237744,0.10551489971432723,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09621875535263133,0.05497774822281506,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025359420571987593,0.07520406587857256,0.7361481809352249,-0.12251382497170038,0.17323266611567556,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08690029919878373,0.1090761427718576,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03187096707413123,0.03667605979387105,0.3854093628395773,-0.10398685511974465,0.04024492097148219,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09591442735545583,0.038664349736575336,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03800805010581687,0.06334515607584507,0.5488576031667125,-0.16256320159897003,0.08654710138733628,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.009356603925290906,-0.04792159408820109,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022850677782561536,0.06926414116386896,0.7416544706896955,-0.15904428957790118,0.11334293401277812,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07782382151113994,0.028620619938619005,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023215265467575682,0.07491037910404025,0.7568032191393159,-0.12408050575985027,0.17051103669500164,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08431714321847066,0.12235699976933491,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11525631430601796,0.07440101805772818,0.12219345244492225,-0.26155053235687353,0.031037903744837614,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06669159691419017,-0.05325427866208584,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02336545694336778,0.061292525281413913,0.7032611264945903,-0.14388453440342885,0.09715362051669328,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11219415710125716,0.08056783775291068,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12387636499424368,0.06976062364341189,0.0765853749418338,-0.261046206927514,0.013293476939026688,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07309290454128584,-0.05491751970151763,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011957470974952476,0.05667447605471319,0.83301318376847,-0.09948116755863659,0.12339610950854155,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.18059609005651486,0.18497212903260987,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014192068453747039,0.064707560338529,0.8265149045071071,-0.11304196931652466,0.14142610622401874,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1103018866922046,0.10649375559212274,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08723358989102724,0.06348794867528741,0.17025458033423768,-0.21206951350564057,0.03760233372358611,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11305229499837291,0.010695924809986433,0.7843765865891925,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007892061325543103,0.0553658985561364,0.886726897138288,-0.11675765278382604,0.10097353013273984,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11006077996231746,0.09383264369032153,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010585682629446178,0.058709368577558055,0.8570090663809145,-0.10485415129391754,0.12602551655280989,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1338900451354876,0.13159309316169768,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06058491498197289,0.05688434828718312,0.2875348490176899,-0.17243622386526003,0.05126639390131426,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08161075820466072,0.006234730460867776,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054864599640221445,0.09965402601068198,0.5822686081929218,-0.1410844369649035,0.25081363624534636,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10268640220940793,0.17813739385109834,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07427960345778638,0.03888556561563099,0.05686664850922194,-0.15074002784055557,0.0021808209249828264,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0794913075657497,-0.017240344402232575,0.5579820220843063,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01728504780793463,0.07701758400758837,0.8225447224964837,-0.1687242017696978,0.13415410615382853,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11774413241364623,0.0937827854001845,0.9796489133048895,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05546622195616527,0.05148238485329183,0.28200014077440516,-0.15669568671512524,0.0457632428027947,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07821094056271263,0.0037651591034999934,0.8770089248428307,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027451465892557075,0.059359384126973475,0.6440174710584567,-0.08926648920448255,0.1441694209895967,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11079312603685298,0.12979176316238725,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04972931026235307,0.05763464114405044,0.38877700852624486,-0.163055914909999,0.06359729438529285,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0637952876245759,-0.0028935244522964904,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05431798558649651,0.057251252428198715,0.343349526972906,-0.16689073559801998,0.05825476442502695,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.045684403838723575,-0.01364819485911148,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006221089336274228,0.06720768193880294,0.9262983280977048,-0.12592892060873764,0.13837109928128608,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09855284420947762,0.10663448208228461,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04713065349792688,0.05034379294559391,0.34978343525348266,-0.14612131269798365,0.051860005702129876,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05064419612943536,-0.03671154317489881,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002703464600151981,0.05750355417253285,0.9625271338000747,-0.11036538462296545,0.11577231382326943,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08331246948530287,0.07588272795580223,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07846868277583531,0.04467715338717449,0.07984285937883177,-0.16631706697998017,0.009379701428309559,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05183564125054821,-0.051026917792683826,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006753894858710063,0.05375755031133275,0.9000870471604483,-0.11245700205307538,0.09894921233565526,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06930599102022811,0.06161118243818976,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014359765310537214,0.04840331996896449,0.7668830209079962,-0.08081535501417039,0.10953488563524483,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09370456628668768,0.10888084252568252,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05828522030165585,0.10632948743191314,0.58390960013004,-0.2673601715009861,0.1507897308976744,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03183840630882842,-0.039727941666957,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0005970934577723959,0.055011638268448064,0.9913457290818264,-0.10876610531100714,0.10757191839546235,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09769889565052207,0.12377742631530572,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03932315012043434,0.07537047950794543,0.6021645073722979,-0.1088773134159324,0.18752361365680106,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11541474008348754,0.15264266792464729,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059448491785044584,0.04915417650653583,0.22725792266312833,-0.1561000162356627,0.03720303266557352,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04398671447155469,-0.030614848295762852,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04854278002128682,0.06781197787842635,0.4745321534014547,-0.1818810129807999,0.08479545293822627,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08881466951443077,0.04250834573601132,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028560031127323266,0.05617953487883658,0.6114915059129217,-0.08190540792329827,0.1390254701779448,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09932582279744448,0.11064279591917632,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019308407509204824,0.06852713269568049,0.7782802875570374,-0.15405284454369866,0.11543602952528903,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08864046848904963,0.08194579376632613,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052044544819031535,0.05722793179877495,0.3637080973583411,-0.06048234999675581,0.16457143963481888,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11858663668304661,0.16137564407243632,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020932044121318716,0.07616598443379873,0.7836043815411627,-0.12883261536453106,0.1706967036071685,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10659436291263048,0.14180837548144037,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00912507882982308,0.04400746508987959,0.8358464578683301,-0.07740650180969114,0.0956566594693373,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11448457086655935,0.1277925408006788,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05544517151365854,0.051600625401251946,0.2832850911611087,-0.15690713186148678,0.04601678883416969,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07783873396286364,0.032445164728462074,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02054568112847725,0.08230058177304696,0.8030005487886139,-0.14128139556926927,0.18237275782622375,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1205514523732713,0.13916725115279777,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011916180523869585,0.056690829182133015,0.8336286245343736,-0.12338697410118014,0.09955461305344097,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09543856353756372,0.09437372879074753,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027253735108068684,0.05509962730071765,0.6211526794391509,-0.08108828898355966,0.13559575919969702,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08753275857638305,0.10391419094792294,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029473746966005656,0.056183615279938155,0.6001726241392065,-0.08099971534967423,0.13994720928168555,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11867906839872756,0.12499945390668639,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045872650999682484,0.03980783495582545,0.24990844477519614,-0.12414652734155443,0.03240122534218947,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03921378303592005,-0.010429782882708896,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07406400008641156,0.05160389153877156,0.1520498473866132,-0.17553238261833018,0.027404382445507053,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08318415277268093,-0.013725473158725632,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12377224099828904,0.062472810923118474,0.04829496199058065,-0.2466121061241297,-0.0009323758724483766,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.007839728936418596,-0.13528657997968804,0.5211737888853413,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02148889082033204,0.05385794672256844,0.6901255918047062,-0.12738940679834387,0.08441162515767979,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1011570640109399,0.06567769133912839,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08063116511104904,0.0631116114159144,0.2021800406887519,-0.20472709932066985,0.043464769098571776,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.025923006318224157,-0.04541424062987266,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04908035852043008,0.047063556799366614,0.2976865413093381,-0.14162111159605542,0.043460394555195264,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09207895863897404,0.01395981071364105,0.8847007730863069,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08892634610001035,0.06644169064892955,0.18157096649961962,-0.21957019255813487,0.04171750035811417,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0069817745088609166,-0.07434912395295785,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07126520562285796,0.04150768463871858,0.08681803733858229,-0.15288148488682293,0.010351073641107017,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03249309567704265,-0.0696509396591201,0.6563443622796822,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05964293418981511,0.048332538273257605,0.21796916661621193,-0.15467887694550453,0.035393008565874316,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0515633679170533,-0.04337304787970363,0.8322459088982637,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002942646629665858,0.047207273673003786,0.9503294954071564,-0.09576598922084258,0.08988069596151087,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07904684388066857,0.06209947568184454,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016904183103405263,0.06494306943948588,0.7947807674888713,-0.14460130082429828,0.11079293461748775,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10345484335106574,0.06966782756405925,0.9733769568556405,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08203515335590157,0.06302399214221482,0.19383312396511043,-0.20595880238090142,0.041888495669098275,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12463270858214152,0.048234721396397916,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06937187990460046,0.08557307078928755,0.418065610571145,-0.09888986978833907,0.23763362959753997,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1258064543996059,0.19945558336955724,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05547216877995606,0.04237515554295503,0.1913091011663388,-0.13879415020943003,0.0278498126495179,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07257369458353216,0.0038710806973393896,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016826100286239053,0.04990458608491063,0.7361803375206951,-0.11495315000992579,0.08130094943744767,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10066515915730621,0.08517665083773683,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029326936108020774,0.05348158962416073,0.583773090306954,-0.13448742367168048,0.07583355145563893,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13422332251791202,0.08322111398093844,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021534630519097982,0.06395634464010796,0.7365246735742155,-0.14729155794791224,0.10422229690971627,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1191332130263083,0.09913006719307464,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04315965525038686,0.061442334924083644,0.48283840781061793,-0.163973302396495,0.07765399189572125,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07354298760322091,0.01435936305792711,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0067729139824618395,0.06752688739815053,0.9201600007868946,-0.12600474749598178,0.1395505754609055,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11624544671147696,0.11048913956090144,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03251080806918438,0.06625863248605274,0.6239494567264428,-0.16279470850109848,0.09777309236272971,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0610390945911417,0.0263298705391865,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11364383642074673,0.09512336853035791,0.2329575347412462,-0.07339659905709268,0.30068427189858615,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1477617410104422,0.2579431487104887,0.8443484327374559,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005164255213194642,0.05957473610742851,0.9309677870566191,-0.12230565545129304,0.11197714502490377,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12363083747923581,0.13516985141959198,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020960287992539232,0.08882850209549845,0.8135894382359432,-0.1537025942358566,0.1956231702209351,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08005249675135603,0.08680932272115627,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06090673887106256,0.06332014579260671,0.3367252203869191,-0.18541271281362431,0.06359923507149919,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0954610518291375,0.044103255913640275,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047014005944381806,0.07359958921861814,0.5233544371972076,-0.09770436800646377,0.1917323798952274,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11632850955994788,0.17347946533286618,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01874672071690761,0.05587441796509333,0.7374235479135334,-0.12861221044592813,0.0911187690121129,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11791270371679163,0.0821865699049347,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09465326229389905,0.05065681728580674,0.062467089321777795,-0.1942594191346842,0.004952894546886091,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.00929026169515992,-0.10675289802375733,0.5810248874960544,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0841828632600435,0.06416302958513588,0.1903154757111945,-0.21034619389683917,0.041980467376752165,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12888264099993865,-0.02674011228599618,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007408832318758779,0.05727719746518126,0.897149503903164,-0.10521493324331423,0.12003259788083177,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0675102613355925,0.06519359307622875,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07217134026682369,0.07767373868898114,0.35340222547402134,-0.08055800620225549,0.22490068673590285,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.15846321941641722,0.24363733022534026,0.9093377198744834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04903909305415821,0.039298363893600315,0.2128566856163243,-0.1263111998959148,0.028233013787598377,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.06210663059251698,-0.12651531298641513,0.8287975391843301,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030632096381910674,0.04781009586647066,0.5221056124689808,-0.12464076417049952,0.06337657140667816,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05628612298693552,0.005902166884482997,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007104616949580359,0.04239722439629346,0.8670095475457624,-0.07626075831678868,0.09046999221594938,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0854863257564634,0.10292221904794518,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026020234517662152,0.06313335532016048,0.680466417836399,-0.15015892361897792,0.09811845458365363,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04471524518269163,-0.0005367555095948114,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021164594439396948,0.03388794285314157,0.5326475547918571,-0.04546903814350382,0.08779822702229771,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09703480811783607,0.13115742099131697,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024783590677794707,0.04254328367101278,0.5605454317679418,-0.10843616130710297,0.058868979951513564,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0940612753061921,0.03860668531032597,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006794107569045624,0.045360522824200104,0.8810183506933716,-0.09598619647024108,0.08239798133214983,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09943522434595062,0.07426741990058694,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04577646704896093,0.09757769996840575,0.6392497832494431,-0.14608990371767047,0.23764283781559234,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12663878086258673,0.18457438077050842,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02804000663452955,0.06565872955698425,0.6695823952235319,-0.15714432199885228,0.10106430872979319,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06508765530036652,0.03329550994180077,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034848830974555614,0.04275575216500477,0.4155495466850936,-0.11891917696501396,0.04922151501590273,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05441384832379242,0.009832803356815887,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03644484000413162,0.0864177169803604,0.6734639877308516,-0.20636741178362858,0.13347773177536534,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08423232673682203,0.05852566812866238,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,1.1375253302707469e-05,0.0641765546025295,0.9998586694729874,-0.1261785495336185,0.12620130004022395,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10756489962606192,0.10128326775709603,0.9998586694729874,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07792626043639088,0.07089344470230075,0.272383002416561,-0.2173235607476246,0.06147103987484283,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07868098892587692,-0.005163208316197509,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01775792552261187,0.061948653517137096,0.7745339622743348,-0.10405129244482414,0.1395671434900479,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13676416065572986,0.15796330569105327,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07212889294035452,0.08197939357139448,0.37950702277999593,-0.23332441945189994,0.0890666335711909,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.018463483528655587,-0.09242418343577595,0.9190136506490566,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.076703627887409,0.07551991160470589,0.31043765101806536,-0.22519791874385772,0.07179066296903971,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05180478356872476,-0.03544084011514269,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053955487432462125,0.07600506096301066,0.47821028700699775,-0.09549274932236126,0.2034037241872855,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07246683525730294,0.14416809831739633,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043009950442146776,0.07061655099318813,0.542850287288241,-0.0958428956436568,0.18186279652795037,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08846399970262384,0.13460744931469473,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09984692477339413,0.061176906112829846,0.10349526387674901,-0.22013866104510516,0.020444811498316895,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.01864869294681807,-0.11021455255521273,0.6840511279380797,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07420521754386157,0.11400360050242134,0.515507057485063,-0.14995929022595478,0.2983697253136779,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.4135573318313975,0.4881611456312194,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05811323938163278,0.06225447919094161,0.35117184158177905,-0.06429732153751383,0.18052380030077939,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11606135731581932,0.1751181245455729,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03435775115669907,0.05697848777412384,0.5468754532566524,-0.07767866356235792,0.14639416587575604,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11908617414931427,0.14826837343383345,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12535941938367706,0.05525567573251964,0.02385183406398922,-0.2340082804501815,-0.016710558317172636,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03817250849188121,-0.09974107922255537,0.3634085581572868,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03360576485005733,0.04671114999034707,0.4723181545984174,-0.05824205310307667,0.12545358280319133,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10879077832043546,0.13008139930210644,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12320786378976478,0.05989497786693876,0.04036928211846847,-0.24097895323128823,-0.00543677434824133,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03707157421863896,-0.10611944418317586,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1281911404933058,0.05960209139575161,0.03213017446063113,-0.24538632924961612,-0.010995951736995455,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.043323322413109426,-0.10026239707631139,0.42865432751006705,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02603686000680868,0.06412932999651415,0.6849695235465219,-0.10006020735705398,0.15213392737067136,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07037038039312166,0.09608370138574644,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05696088946122817,0.05029241194418676,0.2581064672681361,-0.15585051854610965,0.04192873962365333,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07437389731850755,-0.018963495047830337,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017716593675487127,0.058429763956031576,0.7618961535836606,-0.09717345557372221,0.13260664292469648,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13200689049663197,0.13745186178938326,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11220609795872062,0.05572511228644781,0.044767329589435745,-0.22177800894274263,-0.00263418697469861,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.027274304772156237,-0.09082337785553969,0.5055162930315735,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023736430441552003,0.08787777445707327,0.7872258771120664,-0.1965299033517201,0.14905704246861612,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12505842766389302,0.11279848708633523,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06583814930482176,0.06921442400435324,0.3421037109259104,-0.20193400258603167,0.07025770397638814,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0749579152307801,-0.0013019412980470027,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018483667104591667,0.07152475464484241,0.7962215923284,-0.12215497367217441,0.15912230788135776,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0880994791836998,0.09617494355938798,0.973718533338906,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03422007419111497,0.09118457407137648,0.7076611775095079,-0.1450755364109057,0.21351568479313565,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11306106575405676,0.1482858442222172,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02319156137345299,0.04617362211381917,0.6157725945600044,-0.06759931915556981,0.11398244190247579,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12474043941661545,0.13970555157846434,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13284913601986809,0.08017091433011776,0.09833864180167816,-0.2904886620441822,0.024790390004446078,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0008156707405645883,-0.1328801722081157,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10609610041657754,0.08352574269136694,0.2047915958151241,-0.27033220273267,0.058140001899514945,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10408946313384577,-0.016953524818345254,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04738420308932903,0.04559455568361674,0.29935568104580496,-0.1370364692174006,0.04226806303874252,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0738559925358347,-0.004203887702675891,0.8866736552767163,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005487483790375353,0.04664178647111048,0.9064064887586557,-0.0971989127252825,0.0862239451445318,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10934177253323853,0.0837269382805722,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13652214678855795,0.04146787536417471,0.0010880564055609024,-0.21806014934552884,-0.05498414423158707,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05848202914693751,-0.1340423236572423,0.03873090469660288,0.37013945430091794 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014870258676848899,0.047397421871732494,0.7538958382094292,-0.10806748838372626,0.07832697103002847,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1275399594659263,0.0992194207478789,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.20682645726547913,0.04486423081676904,5.524317847689195e-06,-0.2950426905527678,-0.11861022397819049,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0415761800687173,-0.22864291926452393,0.0003654336256246402,0.0034923378070167866 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02451349195313935,0.04327949766662159,0.5714600489683916,-0.06058669127096055,0.10961367517723924,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10514063148491128,0.11049006849818128,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10469532816770123,0.04278970157412755,0.014872556986592147,-0.18883242865145228,-0.020558227683950173,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06738518554145134,-0.08422848136778427,0.2652996794597044,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006969000013169659,0.053575744705681855,0.8965746554562235,-0.11231462407611703,0.0983766240497777,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07969800573944354,0.04909749102686683,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09991887484907266,0.03621329751140833,0.006078079369838312,-0.1711248365519607,-0.028712913146184613,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.056938954140968,-0.0664846145134849,0.15030465432329135,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013361432318201884,0.05221059361742423,0.7981570362437453,-0.11602276903950341,0.08929990440309964,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08360796973569551,0.047346722655750295,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10616667600377803,0.03628833285511314,0.0036460502940816814,-0.1775201791949419,-0.034813172812614174,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06241426036371586,-0.06445180723603548,0.10155209555936978,0.9705024328222499 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002128469089429675,0.04888081718517709,0.9652909600414714,-0.09824248895732741,0.09398555077846805,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08107176849240984,0.07031521283795554,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10100233479228249,0.06184944741141743,0.10329863399080279,-0.22261648446574883,0.02061181488118384,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07263007797324711,-0.10943830638356293,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028083239386196453,0.04338195037372983,0.5178014617259903,-0.057218395902201326,0.11338487467459424,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09037775940062112,0.10009665597649582,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0706247128386903,0.03736605064615635,0.05951653882072321,-0.14409732522534702,0.0028478995479664093,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04116922950927048,-0.047936650468411744,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021602636110310484,0.04738679440996735,0.6487402929407802,-0.07157369689045473,0.11477896911107568,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09757808511808658,0.09667194847007068,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1324453189911815,0.037818918640250505,0.000517127596213775,-0.20680840264833694,-0.05808223533402607,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.054120996205911244,-0.10140808606777907,0.02062793396354244,0.19713487925033316 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031002389939224235,0.048639648848417046,0.5242592379993753,-0.1266422021394586,0.06463742226101013,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06005544003539474,0.010954952081804244,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021380913877860567,0.03948562505553561,0.5884933274342217,-0.09902123107441851,0.05625940331869739,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.036011470332195046,-0.006562934319921241,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08063222845921542,0.05952748576093789,0.17637824806281552,-0.036416263742502175,0.197680720660933,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.17664577951329893,0.2638374030797864,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12999940256503748,0.05925839334419273,0.028863308579914277,-0.24651878016968592,-0.013480024960389012,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.015287686147456379,-0.14624609310657263,0.4046097093301284,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003361350080076656,0.16172108872417507,0.9834382061374713,-0.3155554634183227,0.322278163578476,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16630979589992753,0.227194448728242,0.9987887001431995,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08627795217901557,0.20111224902443828,0.6683867392680369,-0.3103189179036595,0.48287482226169065,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16256524412036036,0.22993401408000536,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05548458739314736,0.05509446375965401,0.31512498772047975,-0.1641318328590712,0.0531626580727765,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07412478029064702,0.025475942073922467,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07002967885037452,0.18195126120864985,0.7007382960447044,-0.28878138836700346,0.4288407460677525,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2581530555644639,0.3219841330017202,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06633505364579445,0.1395172606057193,0.6349823412047564,-0.20879542272819046,0.34146553001977936,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22740524140841245,0.17004713427541285,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10271497772589824,0.1118020609641061,0.3593589849324521,-0.32319059600496614,0.11776064055316968,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09079341340965807,-0.0019187996212247903,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03160204304206439,0.19692669146310407,0.8726695890382412,-0.35674083437517984,0.4199449204593086,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23312442616189952,0.1939043611739679,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006475289216805562,0.05825193933075045,0.9116020201041404,-0.12134913169476516,0.10839855326115405,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16666920408951852,0.09705382063343888,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02942339280679314,0.09855123513577041,0.7655893802904126,-0.164921365343064,0.22376815095665026,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14212847038094198,0.10982582884063573,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11242972486777308,0.20471519538828623,0.583486575268176,-0.29127221841610823,0.5161316681516543,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2509204243567072,0.3110742472215927,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06276140897371218,0.08856072827735419,0.4793552682702993,-0.11188189503892876,0.23740471298635313,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15762008413506975,0.2608443679732517,0.9384017168502401,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11141631660699033,0.1951318870407539,0.5686609865412979,-0.2733871751200858,0.4962198083340664,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.24829460657325814,0.28633994741482177,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05610769399569381,0.14964642554705654,0.7081100438304371,-0.23899767267847044,0.3512130606698581,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16038032961207757,0.2183121783894284,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10222649707185888,0.1676146978638141,0.5426340921971309,-0.22831261665743025,0.432765610801148,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17340880416354323,0.21086598410811253,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.25329900725509996,0.12241850977177006,0.03983311633970804,-0.49471044813541004,-0.011887566374789882,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.033987900718979246,-0.17336666242036922,0.48200499619604026,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2206737540721861,0.12410975867322252,0.07692982402616477,-0.46542036734552783,0.024072859201155622,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.01901596301311469,-0.26630989974834257,0.6304803200848395,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05962497120543502,0.14316646884774342,0.6775150199071205,-0.22270180760207692,0.341951750012947,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1126943926292828,0.10098642376909965,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059795597578971627,0.09710078169673793,0.5387274031448884,-0.13168884103832917,0.2512800361962724,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17615753293299874,0.24096807434680143,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012869483370216385,0.12637203290808652,0.9189882673984177,-0.2620773409743632,0.23633837423393045,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13537484868487412,0.09543166036272399,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020214163053884,0.08142999392784445,0.8042061647261208,-0.1403672081917332,0.18079553429950124,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12357247797274691,0.18665699933201388,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022096658555673866,0.18077753106583166,0.9028398695617443,-0.33439979230580613,0.3785931094171539,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14397490698875695,0.13929012031472437,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007707774816615452,0.1615398117498782,0.9619919524170917,-0.3262671069533725,0.31085155732014164,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17688700061705265,0.19289042289788716,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06227337056329549,0.09090327049025757,0.4941129593420007,-0.24153620876234558,0.1169894676357546,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.028530873194501233,-0.05072889508949665,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04725301665872775,0.1722121016062186,0.7840721609750856,-0.292352257603242,0.38685829092069746,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2632127605924689,0.26439659906070273,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006272948330587409,0.11887736635956014,0.9579697744722246,-0.22815529584932834,0.24070119251050318,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1551075500265213,0.13347378625687095,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10318490669186875,0.06644467988282325,0.12203329277135544,-0.02784516334613693,0.23421497672987443,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17156231915661524,0.24071182323945461,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0444504832623474,0.07488974775413575,0.5534934834222864,-0.19213437474407483,0.10323340821938001,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0788580263351444,0.039845239911037424,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07145390917725232,0.06665324941135219,0.28501397899265574,-0.059987463616356,0.20289528197086065,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1528066004309808,0.2070698632537632,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029532439751334776,0.08560758768319413,0.7304796734400735,-0.13928721939512176,0.1983520988977913,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12893429928107591,0.1535477577802009,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035789515908813616,0.10137834787030053,0.7244421079448167,-0.1641303579653437,0.23570938978297096,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16443003634866749,0.13700836076822123,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09726547647669025,0.17082794167867482,0.5697457819939526,-0.23961021021604584,0.43414116316942636,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19730733187263713,0.2587950984505572,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07184133534147795,0.18669312430198193,0.7007913875205198,-0.2963207687734464,0.4400034394564023,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18363062861335994,0.16964055617398152,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00437190889713398,0.19446802824417472,0.9820866076421126,-0.3791224416802742,0.3878662594745421,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21458294300379843,0.1617439905263613,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019431067463501026,0.12478740007481305,0.8764175877488835,-0.2655140014244831,0.2266518664974811,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09551252423598214,0.07889894581285221,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027694755989782924,0.19580732316022298,0.8876670925996458,-0.3584407075700465,0.41383021954961235,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17518074092215863,0.18121665108485377,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09772093040480165,0.08996798898985331,0.27872240392447717,-0.07969751632875655,0.27513937713835984,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13998075375996027,0.1595010210087705,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02982544118037744,0.16108317498523436,0.8532965689853169,-0.34748427763623535,0.28783339527548046,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14927453909857058,0.07341366253871562,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07234084229316817,0.08416642905521705,0.3911054673774228,-0.09363682685058647,0.23831851143692281,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12453314622109227,0.13283641139352775,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02119653726997471,0.07549315235738692,0.7791766812560799,-0.12767727863556944,0.17007035317551888,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11587850457849226,0.09282595267405198,0.9703646839991782,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06711314945715938,0.14510173960981443,0.6442129177499243,-0.2190300171174975,0.3532563160318163,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1744351154313527,0.1717302566345086,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037037911529813485,0.095507364843828,0.6985794238219293,-0.15130428120407388,0.22538010426370084,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11347192415396486,0.0874090584375054,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0635042446605332,0.15239713710790034,0.6773475281354138,-0.2370255732880948,0.36403406260916116,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15958990198668005,0.1729986534375759,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005845709703182122,0.1358070202009069,0.9657096462326071,-0.26196810774554724,0.27365952715191144,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13797879931809368,0.08371489422582358,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10329992324040746,0.19032638566504426,0.5879113510511295,-0.27202703578401444,0.4786268822648293,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2034028814847594,0.2413115327830088,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022885037678183368,0.10938982114171027,0.8345022915119983,-0.19283360151039305,0.2386036768667598,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09256793834118882,0.09176364806730901,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010403048440099288,0.132335302644163,0.9374211979593191,-0.2713705781888268,0.2505644813086283,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.130616438786495,0.07770853084614558,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03941788211201159,0.1499593990247411,0.7929340881756226,-0.25630467373024507,0.33514043795426823,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16662218429084322,0.1417696413356615,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019003440696637775,0.10852109057886702,0.8611698788791409,-0.23300892803175885,0.19500204663848328,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08538067444936763,0.03791475965071201,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06183299091487515,0.10663002891657235,0.5626524720681858,-0.1484432897705392,0.2721092716002895,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09208626184800127,0.07216272440181427,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020312405151292873,0.1253710505049898,0.8714566542436482,-0.22692149765894307,0.2675463079615288,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16052015978743042,0.14652551611628878,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016381117772371584,0.09170757730937057,0.8584160667401474,-0.19723006307625351,0.16446782753151035,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.01177237418152514,-0.005384886277684325,0.9839047884462332,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016610950037604218,0.09454857325582393,0.8607194362478788,-0.2030623890023474,0.169840488927139,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2050150738042658,0.10138593600590186,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02366265369643712,0.18010787036347262,0.8956077488151353,-0.3788385219486466,0.3315132145557724,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15104055673410488,0.11185025248280327,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03729184705841143,0.06600618298765551,0.5727302852071385,-0.16745719355517044,0.09287349943834758,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10132848398699346,0.10289216271319351,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08941516155289898,0.12297702797090382,0.46803063823488655,-0.1530976869777912,0.33192801008358913,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17170863020263485,0.19890397381183575,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12384026742779684,0.23594466683778592,0.6002607768500634,-0.3414467393780125,0.5891272742336062,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.32583976144288673,0.3578779311282581,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08392291161492613,0.1068312174588567,0.4330611475599362,-0.2945959396220651,0.12675011639221287,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15641999167058396,0.04461792013947071,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1342208800174239,0.1517622424060185,0.37754464503908847,-0.16505691448250895,0.4334986745173568,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23353193473701284,0.3776613222565908,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05538187199810855,0.14097629150379126,0.6948563636339868,-0.22262583880757392,0.33338958280379105,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18340170494676103,0.17201605850489612,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09943870540421627,0.15594462356458147,0.52443566326814,-0.20808681783936595,0.4069642286477985,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17424831901663798,0.2421125739733835,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008757397212871805,0.09998169045714243,0.930291063746264,-0.18840824383199148,0.20592303825773509,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13884169675150768,0.08559316595482765,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025136862211903158,0.10647448869392682,0.8136119647366201,-0.18483269043594802,0.23510641485975436,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0533565340046579,0.0579110213308868,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039861365071597404,0.19369360071754194,0.8371617177011987,-0.34210580088797526,0.42182853103117,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1998462548584827,0.1384666935622221,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08301508075706912,0.1205580418674707,0.4918872375154203,-0.1547274848990136,0.32075764641315185,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1620704272351296,0.21648119545927522,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0688990875827932,0.12718784230377841,0.5886264794201254,-0.3197157355738255,0.18191756040823912,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1105733135392029,-0.017225174982859724,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02202609279132538,0.09608240591964858,0.8189176951321239,-0.21150227657720333,0.16745009099455255,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1599721086836813,0.10628348728555737,0.9783899072890752,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055053722078298416,0.15155411442830052,0.716797339222711,-0.3539210845685452,0.2438136404119484,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1336685091171676,-0.0005523173366257702,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008663914772057957,0.0673428185806143,0.8977621171712635,-0.12413730047551065,0.14146513001962657,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19192640836463834,0.165409551548483,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025737306947724626,0.13517917472599578,0.8491954450872132,-0.24083838825110104,0.2923130021465503,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16306581951861018,0.0954698821969606,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05952594737597179,0.08840776301031399,0.501534402663134,-0.2338676012085079,0.11481570645656435,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16992281230366807,0.062370167709582335,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1024732893665506,0.14984838971038167,0.4948716653537204,-0.1930303541675869,0.3979769329006881,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16552874389643696,0.2161763500970737,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08204234047857596,0.1325264404153415,0.5365858525728853,-0.17930211629558984,0.34338679725274174,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18866513288776193,0.2143786468591176,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08927219311565218,0.15008426315001755,0.5526470583649497,-0.20669659696400408,0.3852409831953084,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1411412764120135,0.18244832822809878,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048026771634971765,0.1811137875287633,0.791150846957591,-0.3091327828484441,0.4051863261183876,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21818307869834172,0.3108685172041291,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005640486327244659,0.08578087627573706,0.9476395536776913,-0.1748018736069051,0.1635209009524158,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1448970003188529,0.05548897352525652,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10295192108934896,0.16620037159536424,0.5363356415163996,-0.2247981165191974,0.43070195869789535,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2400601905285812,0.2917732486907561,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033676323540889744,0.16466428651113582,0.8381611105009743,-0.2910445274341183,0.35839717451589775,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1431800225841999,0.11263018068765414,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08331999973237318,0.13712678927919628,0.544140513596397,-0.18709642540544752,0.3537364248701939,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18120587305744706,0.20368361642688382,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005743461850153432,0.1498616157491624,0.9694670898472539,-0.2897862636636222,0.3012731873639291,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1559661209651582,0.12693617626716888,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010088505990906462,0.10756168143746685,0.9253686321277408,-0.22220202173079276,0.20202500974897983,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09327499688067001,0.059463501933729374,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08399443772800619,0.1487154854610021,0.5728494448034881,-0.20927509882564255,0.3772639742816549,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17128296753557348,0.25214197466285926,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05134249700870059,0.1770673545802472,0.7721500690705687,-0.29783742097735855,0.4005224149947597,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13925554126066203,0.10654104919094037,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11244062899193154,0.1469563306731118,0.4451054291519657,-0.17735982357378238,0.40224108155764543,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.137381044341765,0.18448257551587421,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06527398257263081,0.1988484502506823,0.7430620009942044,-0.3268586367618985,0.4574066019071601,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11792734010652235,0.11727827476527129,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016623967678641507,0.09827467643984604,0.8658448943442736,-0.17717541188920582,0.21042334724648887,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13609598013403962,0.1399462230380302,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01782717719871239,0.08637356897854093,0.836693511590492,-0.18815736484728665,0.1525030104498619,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10885366278400685,0.06874099896544562,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09004196329942799,0.21848155231822122,0.680692791337134,-0.34080747645638493,0.520891403055241,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1274731209633239,0.11840742721837326,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03635294612735485,0.06176580554178836,0.5568265774665935,-0.08545030193354147,0.15815619418825116,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14868691870486114,0.20579048977938805,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062227327589945924,0.1684803079728165,0.7122654165035989,-0.2700187844032856,0.39447343958317743,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1843102588945296,0.19127583895280234,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04557961430454204,0.0797604425850271,0.5683384261205942,-0.2028686011219824,0.11170937251289831,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08634409256849052,0.0035362442251870075,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08819868176508125,0.1610353017193261,0.5845162900692283,-0.22936574777368454,0.405763111303847,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18070222069795996,0.24705172749033802,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07992150112712877,0.16068545533925332,0.6194739971404559,-0.23695302523557665,0.39679602748983417,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16233519874187202,0.17153783656395905,0.9576211468940484,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008338695937796533,0.10208151565446537,0.9349784172992583,-0.19296783709658358,0.20964522897217666,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14400003833747613,0.17233237665818446,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10426496812702085,0.13237989902102923,0.4318612379863639,-0.15679050645633497,0.36532044271037667,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14577067154288628,0.17284044509339394,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02492463799671859,0.1392143495000925,0.8580910518595993,-0.24960849238274027,0.29945776837617744,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20059815638080564,0.2369485864042322,0.9838981322636862,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021036372002383594,0.07774556586587357,0.7869961520998088,-0.1322792427092054,0.1743519867139726,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09245394119278726,0.13483701472005657,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023475245008714337,0.06185573772388601,0.7047114126625857,-0.14545584090452696,0.09850535088709829,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07700416133658984,0.08478546211160785,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04454796423671568,0.1477303552733196,0.7633122383015924,-0.24677887836888138,0.33587480684231275,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19554501823691478,0.19876022148597086,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0238718791694625,0.0969395309435858,0.8057396641838344,-0.21503832848323345,0.16729457014430843,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1546836698475662,0.1330094770448958,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03736511668996738,0.06778904636897122,0.5821201119527069,-0.09631606755533624,0.171046300935271,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11939174213059978,0.14075666996206357,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06419460431695126,0.13603702370918275,0.6375244329830039,-0.20407278407006116,0.3324619927039637,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15668348398200901,0.1223234489012573,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0032806141115835816,0.04344518489632692,0.9398839323818601,-0.08239404983169829,0.08895527805486544,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07319281687731423,0.047647698980877555,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061924309114060404,0.10629245707143811,0.5608360755505823,-0.14768627399272458,0.27153489222084537,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1315396877226303,0.10864749992212286,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16223229249995194,0.06485625434010016,0.013180348269898992,-0.2901299596054699,-0.03433462539443399,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.044512188054564625,-0.06439038171625791,0.2450248350502534,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09265353748639224,0.12009018656452489,0.44131089002755786,-0.1441664093351841,0.3294734843079686,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14189223094056302,0.1652778914373185,0.9321782450874811,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1140221183582241,0.0794029985424859,0.1525824464855593,-0.27060621927642564,0.04256198255997745,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05155537174910784,0.02947006865418306,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07373470029789134,0.126109664220863,0.5594237389366834,-0.17495576166941437,0.322425162265197,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12109153310469123,0.07953642742971338,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13051553092621723,0.0722684817816217,0.0724399400575673,-0.27303024009609567,0.011999178243661202,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.04274037253059484,-0.007669615682607771,0.6229991811234771,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04367213968179863,0.15230536185553234,0.7746107316267486,-0.25667669586512704,0.34402097522872427,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10997022971867393,0.06555964389965574,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04036072063833069,0.12585927161008909,0.7487900823656106,-0.2078359627242084,0.28855740400086977,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11788548984105038,0.07474253028075532,0.9640825891897521,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03214957237451812,0.11988084894822978,0.788840428588069,-0.20425755700895618,0.2685567017579924,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12383459645140996,0.10718678564308949,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043559581932583954,0.1467173672090187,0.766858262782022,-0.2457696305053746,0.33288879437054253,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18889701044559207,0.16731474587545095,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001750413045186955,0.12391275663804759,0.9887435429586686,-0.24260770877162094,0.24610853486199483,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19298043408863869,0.15584486236384684,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09652374213303809,0.1305096607994852,0.4604242919244903,-0.16084358998971993,0.35389107425579613,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21367433928713228,0.27902878300711237,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03690142097454302,0.056317408798881974,0.5130737629444782,-0.14796033543225467,0.07415749348316865,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11084729471515418,0.020689758014659655,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028456121644666665,0.10030122910080301,0.7769316668721227,-0.1693396551903386,0.22625189847967192,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1504000737192824,0.17030536713382563,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10881715414115666,0.15556467838961763,0.4850619211828403,-0.19795911057677817,0.4155934188590915,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22102342193026014,0.23668346380554492,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04197608487158148,0.11844339639406312,0.7234178941148125,-0.1915963629515192,0.27554853269468216,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19197405018980016,0.2433181072225036,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042616143721031674,0.12792136488452474,0.7393786221001896,-0.20964702361961823,0.2948793110616816,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17048575241338565,0.15369141646831266,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015333025172784178,0.1384346680800062,0.9119188470508988,-0.2576625598191221,0.28832861016469047,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1846488330310759,0.14418970678717621,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02852604754777071,0.10391246134503859,0.783971257194583,-0.17639114238938444,0.23344323748492588,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09340287051578611,0.10251358799754663,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11038338619883047,0.11926485920544264,0.35581616700860785,-0.12480900064570118,0.3455757730433621,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.25277209602835304,0.2813201398799772,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0879863667712786,0.11683953215667102,0.4523124726105534,-0.1424232327436121,0.3183959662861693,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14451995557569672,0.19033893462760765,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09295064020547102,0.15906498681003553,0.5596457703040847,-0.2207282938953371,0.4066295743062791,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22173401661868306,0.27307191914586343,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027517058417911352,0.12162261140428501,0.8212407409525957,-0.21232485697113876,0.26735897380696144,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11872126859819496,0.10157829539178037,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16006769440133378,0.1255328471958542,0.20376586203597052,-0.08748527431114242,0.40762066311380996,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1949033608962838,0.3610694763810857,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023070582347141683,0.11981766078465197,0.8475107672607942,-0.21321193887336495,0.2593531035676483,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18774931556562338,0.14776997963315544,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14165676871058633,0.05222513888825349,0.007267279427271149,-0.24464565538052485,-0.03866788204064779,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.026575995079436393,-0.06346491185799172,0.1672106205613866,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15304572296855462,0.27099952834755314,0.5728862379232098,-0.38137008341756234,0.6874615293546715,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2911492949089512,0.19513007624502476,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00018581651125312206,0.10116502991230632,0.9985363226431434,-0.19968502364391003,0.19931339062140377,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15431390356018762,0.11860705658248216,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09403746510476768,0.1348141388064501,0.48628683814132145,-0.17181837288067675,0.3598933030902121,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.274173243483055,0.3557460046793641,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07533667693698544,0.06361863795910166,0.2377567062036743,-0.2007937429083208,0.05012038903434994,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.03710681885605739,-0.1295834481565643,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010656351854677079,0.14066439700600417,0.939688694883206,-0.266736297550129,0.28804900125948313,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09831778998843421,0.06038282744241504,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030379501453372305,0.06053616371516969,0.6163372630554189,-0.08899887143395642,0.14975787434070104,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1229408100303131,0.14405665855743352,0.9561867293882707,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061510113272216865,0.18410032007009414,0.7386487091912467,-0.301538935580823,0.4245591621252568,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.109013534494645,0.10776726545185251,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020922363526920763,0.060108389422967416,0.7281519422767653,-0.09761243097961705,0.13945715803345857,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11672859752831902,0.1326310188245185,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07558387588735078,0.16083651319734318,0.6389134330056478,-0.241588539211672,0.39275629098637355,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1680081680092833,0.15431423560365023,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02749571742171319,0.1275844883427157,0.829591645805398,-0.22410312349061706,0.27909455833404345,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16350526033082083,0.11264540367704655,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05661545422990478,0.12425751871589137,0.6491553387355933,-0.1884225444301054,0.30165345288991496,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20129037208495312,0.24100152047788637,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0544674220136897,0.1237418429891712,0.6602942551945381,-0.18955365510033356,0.29848849912771297,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14441610643368014,0.14128500115626258,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05275980314117245,0.07950883877892859,0.5077364476839176,-0.10403301657315212,0.20955262285549703,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08555918092845576,0.1028707545131241,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024475690753902955,0.1698134458474644,0.8855421830958528,-0.3103993924284966,0.3593507739363025,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19283249094881624,0.21218024048666292,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05498838881827883,0.1192407501819609,0.6451940472549204,-0.1801564546105733,0.29013323224713095,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17319612431419432,0.17996652827853135,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0515009200868618,0.09642378315941322,0.5938644967899068,-0.2416503057560903,0.1386484655823667,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1412421556458098,0.08536469971239068,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010630188739090088,0.14288999044769277,0.940771817011306,-0.2711513698312784,0.2924117473094586,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.218846132040539,0.19290171383196095,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03402120016439154,0.11709799857794734,0.7717101871786659,-0.26494049997947233,0.19689809965068925,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10609447827692087,0.13222164837675424,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07927808809699546,0.15232156865706628,0.6033208119059259,-0.37965888373980583,0.22110270754581493,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1524041267417053,0.012027644383751876,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04034542148490214,0.1291298668276628,0.7550344551048149,-0.2143009328096123,0.2949917757794166,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09938856267025437,0.11973590810037626,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06943826547177297,0.1292887084941843,0.5918159854390164,-0.1855213273653301,0.324397858308876,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1860372243068824,0.20953557861323757,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04953110698357415,0.10793832387614256,0.646821218693419,-0.26238736819542297,0.16332515422827465,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.03882462071562142,0.0029496636138386157,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21704925710942724,0.2644876914932672,0.4128380824132297,-0.304525093187235,0.7386236074060895,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2756196201519482,0.31334503591783697,0.9262602312595302,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11496690561951413,0.12640498800455532,0.36418549994482563,-0.1343059400108529,0.3642397512498811,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18679059228989414,0.24147476961847306,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08945560986568309,0.12878153435438633,0.48810104022277634,-0.164503826703433,0.34341504643479914,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18272342970143132,0.18604486605770545,0.9404802865694325,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062277661180078714,0.0932415327277571,0.5049639835958804,-0.2461515933792369,0.12159627101907947,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11129443248993269,0.004952541977204471,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07421318908021561,0.13093602696069254,0.5714990299944676,-0.1839949445644002,0.33242132272483144,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1879077361638608,0.2018161058031209,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0328513843816442,0.10804110572078815,0.7613986275480461,-0.2459103331875381,0.1802075644242497,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13395892275576016,0.045435911838914766,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04814600961354658,0.09000049288401535,0.593282798069233,-0.22562855459449,0.1293365353673968,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12330534654683889,0.014756823071407818,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08263714358968652,0.16209541497713423,0.6107554647094413,-0.23701784782196036,0.40229213500133343,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.128825580303219,0.222947373234355,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06338776400563002,0.16965474678843595,0.7090808440554313,-0.2711743618586496,0.39794988986990965,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15875409753973904,0.11788364133829453,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06135738692470773,0.11988162984127906,0.6093498512338154,-0.1750512823935081,0.2977660562429235,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19876799777785098,0.20103506113567937,0.95480045777616,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14454446634916915,0.09864054335003315,0.1444073247867566,-0.3390653418584666,0.04997640916012827,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08905355212766698,-0.06995092317940414,0.7635967032883216,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07687284781899781,0.21080738596974585,0.715755006602522,-0.33884300176981696,0.4925886974078125,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2263434889012042,0.2591435603556565,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05523088437926169,0.124382611481107,0.6574983940733006,-0.3005155681586277,0.19005379940010428,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1668982787189242,0.09353811170070125,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04648740028304792,0.1270219090490993,0.7147711816505944,-0.2040020244296033,0.29697682499569916,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18469525804884257,0.1294449876743626,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0733418742101791,0.16197174139862763,0.6511837740550093,-0.24606923074310652,0.39275297916346474,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2041103303474291,0.26375148530359743,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055268304851265986,0.06224391726900012,0.375655209986439,-0.06747778789204928,0.17801439759458124,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1852759418607021,0.17041632225667225,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08725590444725437,0.09127769953673696,0.340268783197904,-0.26725712327017054,0.0927453143756618,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09784439126739794,0.0939921676761662,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062302223008758456,0.22145130414962383,0.7787464979675085,-0.3744036192634096,0.49900806528092656,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2324839841535038,0.21021217207649542,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052941855538797426,0.1540031204734066,0.7313830525791043,-0.2507549896757194,0.3566387007533143,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14933857767499473,0.11359294948619765,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02308243770043538,0.1174972689587828,0.8444587918708581,-0.20862423028403435,0.2547891056849051,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11193825782413225,0.05599852309123249,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039188601704858085,0.19513382088968392,0.8410381439643955,-0.34561870360610747,0.4239959070158237,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19011201231852703,0.08594567169241552,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004754838069163643,0.10898957039878461,0.9965235089308546,-0.21445385392109464,0.21540482153492738,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09115846756363512,0.01829874768198055,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07387197250548089,0.19011491356735655,0.6980155682340865,-0.3010379598462266,0.4487819048571884,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2010573044521066,0.12692392156933446,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028280776456252536,0.11502637524429513,0.8060426452820592,-0.19855324593737755,0.25511479884988264,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1177835330568516,0.07393268135237538,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020677833324420636,0.18679236855951906,0.9119667208217995,-0.3476799822009416,0.38903564884978287,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18247089065624908,0.0835944211107497,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05830072966010459,0.1251495706420591,0.6418360401222802,-0.1884964109894437,0.3050978703096529,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.132337422544808,0.12623763797189044,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004776970496259014,0.1099281966574197,0.996537149089181,-0.21630262806556733,0.21725802216481915,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12739149085105064,0.06928298559714781,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004955322225678491,0.14710682599107594,0.9731621175015974,-0.2851419097373928,0.2950525541887498,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15919129140860314,0.09515692271250431,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020145101418241964,0.07482601629386462,0.7880361961872017,-0.16770331334642685,0.12741311050994292,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1012611959308935,0.03297874740675428,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020474172286458543,0.11392660505759965,0.857561116589646,-0.20419108407740744,0.2451394286503245,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09409184795095163,0.05762827964681802,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11974837837554457,0.2790026274197246,0.6682431494738537,-0.43044967925773076,0.6699464360088199,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.24057302478331136,0.12738489698704528,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06642600914205683,0.07169320431624404,0.35529782292399215,-0.07495424281149289,0.20780626109560657,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05944262162914117,0.05493206079380894,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008262622646564107,0.13882091111354572,0.9525979543742406,-0.26549464035817366,0.2820198856513019,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09916070242323542,0.055464023485341185,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06932209980757689,0.11626941920616259,0.5517095746515213,-0.15996322700457175,0.2986074266197255,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.123403906872634,0.1260095698457662,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02097788670443675,0.10179772268056674,0.8369446689273704,-0.22172477503420232,0.1797690016253288,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11498323781797166,0.02003752800105287,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026643253637774224,0.1391631438965535,0.8483665923705848,-0.24778889839654264,0.30107540567209107,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1047068108603052,0.0731174216791362,0.9827413793708789,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016773210700944202,0.11942743784107544,0.8884496955279895,-0.25228620545646613,0.21873978405457772,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11433951226318011,0.059323580875444155,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04427381118489786,0.08991761094263216,0.6229948543380637,-0.13304528915904112,0.2215929115288368,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1637025418225421,0.11121670596937623,0.9584620018167673,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03659543945519805,0.10009879050378295,0.7150589023420157,-0.2339920038386916,0.16080112492829549,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08973525189254826,0.04071029338686575,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.23830788715957335,0.14231691059070056,0.09550937398192479,-0.0422296281698083,0.518845402488955,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12759442927952935,0.2890037448492654,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17687518122623125,0.09605113568232693,0.06695000020609546,-0.012462451505138916,0.3662128139576014,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14139633571697402,0.2545082178402736,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24014627866006844,0.09277192426136632,0.01030462680934321,0.05727268326943105,0.42301987405070585,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.029928425423882028,0.1987821338646141,0.2065609283145616,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22375793960954607,0.1178721773936211,0.05901361138050474,-0.00859370177460378,0.4561095809936959,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.25202178900664873,0.43162639467936187,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14896585285275193,0.0680276637164262,0.029630950879754602,0.014868564811172102,0.28306314089433177,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18399133765396616,0.21710488357456972,0.4097743694834356,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16882501693527807,0.08703131572859009,0.05372831884812266,-0.002732593253183868,0.34038262712374,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.003311040363434904,0.023634970507196606,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.30210235689200926,0.1356320533205023,0.02697401049806749,0.03474214594008446,0.569462567843934,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18821647653468832,0.3740345037375399,0.38930853697029044,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055786946006662966,0.12950948718136973,0.6670836613653679,-0.19950435841136543,0.31107825042469134,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08598469814761854,-0.010423228605353774,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15079898920875462,0.0924308361724402,0.1042738211103542,-0.03140224753821477,0.333000225955724,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1280348460284966,0.2344299402901012,0.686265063428165,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.26326002928851006,0.10845911461318951,0.01604787134625688,0.04946357739731083,0.4770564811797093,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24486916284437774,0.45437055958220834,0.27874836487218185,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2000564494327899,0.061724285795025,0.0013825764413703584,0.07838448718638319,0.32172841167919664,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11346273034916438,0.23917933762256305,0.047510354076181406,0.4540419767923369 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.217461408807055,0.12293865735322314,0.07835497548142357,-0.02487736406718591,0.4598001816812959,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24440123987592427,0.4098048813943173,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11711638087350643,0.06758137722157465,0.0845554454250035,-0.016101179636952484,0.25033394138396536,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13757471391692488,0.20048849792782178,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08503975815174059,0.07065199256434695,0.23006996822727888,-0.054230651561375964,0.22431016786485714,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15247693777685817,0.17636093503238082,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061426068653007385,0.13813824155802326,0.6570111672719008,-0.21087438318936153,0.33372652049537627,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.007028462256547205,0.0029474291925936182,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049310800657580464,0.1520220360607666,0.7459806688608537,-0.2503576231072892,0.34897922442245016,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.17329669622396582,-0.38290750244938915,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18562128777238368,0.07340141499408886,0.012171417753751232,0.040931169791084215,0.3303114057536831,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11782154702255009,0.2926907296961394,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19764733017205405,0.0615691624895134,0.001532659205601899,0.07628114962451417,0.31901351071959394,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14626491446608678,0.2773569396093934,0.05133438301294462,0.49058705610231235 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19002213292886005,0.07427220939652604,0.011211216149920877,0.04361549020704658,0.33642877565067353,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1246264556039927,0.279239967277024,0.22034340329509305,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14750062894876653,0.07772208549125383,0.05908175502328757,-0.005706468222150207,0.30070772611968327,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10636897847345608,0.22592475390803898,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2268695899778874,0.1064180634549127,0.03416818479733736,0.017096492853360207,0.4366426871024146,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11901802370975346,0.29464710150663126,0.4446345097069901,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20729260506612032,0.12224968435111187,0.09142033517038903,-0.033688052505173954,0.4482732626374146,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12944703737562666,0.2337005411370491,0.6648373299485711,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12975342759995068,0.08158482594079307,0.11323221416744593,-0.031067969260147543,0.2905748244600489,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.001592553330098128,0.08206797202785822,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21347202283009675,0.1660167130570568,0.19989930162331232,-0.11378294631494673,0.5407269919751403,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.21747236462883246,0.3194566971995091,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20136435976321757,0.060959625570275955,0.00112178613769642,0.08119970876065342,0.3215290107657817,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11785634261150844,0.2481166370057082,0.03975329625461689,0.3799101388828962 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04824384788483814,0.0658486609728195,0.4645827932568781,-0.08155815287815966,0.17804584864783596,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11352559187137835,0.04637794675759,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16898113144358695,0.06593186366632228,0.011071014715257227,0.039015120115666796,0.29894714277150713,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03512881308910993,0.13587884981484002,0.21861123086993003,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07390717082065851,0.05811457960081741,0.20485558569511259,-0.04064927716543343,0.18846361880675044,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08678287429030501,0.038531035892547416,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14807055622923804,0.06501641815450944,0.02375784730596832,0.01990908666826227,0.2762320257902138,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08147986094436689,0.14666043688353322,0.3634085581572868,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07891602543586052,0.043587439168647255,0.07163062056021684,-0.0070042761866922765,0.1648363270584133,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1519909243033299,0.1789410224386655,0.6193941895501103,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11552329640254974,0.09715360845161494,0.23573879987836854,-0.07598754940750971,0.30703414221260916,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1708434521074332,0.23155491431301925,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3589011427222725,0.14037944691968898,0.011267767080054378,0.08218278874237878,0.6356194967021662,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1611015510353962,0.4362933682124858,0.22034340329509305,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2717562149511228,0.13212972418089658,0.04093581952256207,0.011299854782724494,0.532212575119521,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1867051237816305,0.37017953887943805,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060593008328262504,0.08554589754631298,0.47953087864584865,-0.1080365202685496,0.2292225369250746,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06363360031591912,0.07022479206736192,0.9384017168502401,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10856527078321222,0.07760237085434839,0.16327603011009106,-0.04440584285878575,0.2615363844252102,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16419528563508082,0.22053877472168962,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2314081005130023,0.13433756345791556,0.0864216004694736,-0.03340038999922312,0.49621659102522775,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13484987233207882,0.3194071465171288,0.65578639613287,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07777368431055709,0.04660423159912348,0.09663082919455393,-0.01409336987427054,0.16964073849538472,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09726436367976879,0.06650651283730417,0.673446463693037,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2312522750419926,0.15826750076378115,0.14545532104992032,-0.08072731499671507,0.5432318650807003,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09007761631383264,0.24430256527804453,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10807047911896162,0.04250889042003406,0.01172637534827915,0.0242762311385354,0.19186472709938784,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07269960816261385,0.0928468647105934,0.22587028943799292,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07378441861055157,0.026858464623590424,0.006528808251205518,0.02084055621366434,0.1267282810074388,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13972894685494525,0.12954165585797364,0.1556009807507485,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16716287853759063,0.05185215083827776,0.0014646284470919743,0.06495103666807446,0.2693747204071068,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08107818638415548,0.17391259512053614,0.049684703474427744,0.47482157143467474 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12419838950647186,0.07027459622205362,0.07861167392604565,-0.01432809011624342,0.26272486912918713,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15005727356928736,0.23747634338643805,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11704968888105886,0.06772313477719288,0.08538042927869803,-0.01644730653469166,0.2505466842968094,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11730988789552045,0.1724828591224354,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05405385353343638,0.0529829234448178,0.30879038686972,-0.05038698653541254,0.1584946936022853,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15603839849483958,0.11327090430156446,0.8972101357876419,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1349787321603919,0.058133134779746104,0.021188163677058593,0.0203857078899249,0.24957175643085894,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10582696699273862,0.2517187606220076,0.33504311408065957,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07872980142043234,0.060149979643479,0.19198810443300385,-0.03983886175709103,0.19729846459795572,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12205585826332277,0.16844906054718578,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11054564356000664,0.0661950581462464,0.0963954654601298,-0.019939181204348164,0.24103046832436142,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15702409136428758,0.2276624528282298,0.673446463693037,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13761281627405245,0.07283161988505178,0.06019427208005911,-0.00595411189464759,0.2811797444427525,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09018375971422136,0.22613605617458807,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02395516167647988,0.05528163106642751,0.6652159841911792,-0.08501692996295532,0.1329272533159151,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09493347650445662,0.09690813050324654,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08648448493173244,0.06507922286143335,0.18530588603216402,-0.04180078633599971,0.2147697561994646,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12763989044568452,0.14082768834485507,0.8064463395412927,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06965859554247715,0.048530869485520454,0.15266220335565422,-0.02600628002103192,0.16532347110598622,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.022803240699317627,-0.0012536331555173437,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12436945924258089,0.04892523428797001,0.01173523018623457,0.027927205071333908,0.22081171341382788,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09340857117611837,0.008923991954683241,0.22587028943799292,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3061484427611747,0.12939439665030436,0.018882313528870924,0.051084006755965305,0.5612128787663841,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11218742117584277,0.32379681167293084,0.3146632024742357,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08799965027889356,0.0352881515447283,0.01340473488062966,0.01843904561262255,0.15756025494516457,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06054251412089507,0.08628308591342575,0.2480344649940285,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09660289835337349,0.08618985421868915,0.2636345662365633,-0.07329600859136903,0.266501805298116,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15817186691708782,0.2021626052086697,0.8672735958499126,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00312007980238967,0.09193496565833978,0.9729586012508138,-0.18434384815594437,0.178103688551165,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.283374745064712,0.15576448048695923,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12062996030777146,0.09130573149860133,0.1878704354410332,-0.059353450965231674,0.3006133715807746,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10425775007958292,0.12237481532590626,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0962888400075291,0.15866238663707383,0.5445807237027754,-0.21646915578262718,0.4090468357976854,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24421767035346326,0.32587539979647423,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13502175561876056,0.0478408864359505,0.005221537283198559,0.040716986380932185,0.22932652485658894,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1709714309948052,0.25545492000473097,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05537131702133488,0.057539091636937656,0.33698262157318915,-0.058050719299841805,0.16879335334251155,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15964538737522596,0.1718724032073757,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07480016044745974,0.0427722529683161,0.08177273346873246,-0.009513232268607508,0.159113553163527,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07333730137134124,0.03081030847888554,0.6428846031996515,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17004656730130127,0.07591468410753321,0.026130703027676703,0.020402250486473844,0.31969088411612867,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09197415146651149,0.31586268562898995,0.37990022094083825,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13546226859579816,0.08836123328563104,0.12675424272442895,-0.03871689770638656,0.3096414348979829,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1513701224616576,0.16785541686615393,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.25251635116044957,0.06428117773772392,0.0001157348547329446,0.12580420001735285,0.3792285023035463,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1488999340345452,0.35344100736852874,0.005436114064320203,0.05195128564764741 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24936152361225822,0.08804260909196798,0.005067230174715926,0.07581043474123089,0.42291261248328554,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07487767596285132,0.24309026915886456,0.1336334655378572,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1313546549984764,0.08136620223665746,0.10793589541363623,-0.029035787096683863,0.29174509709363666,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09171460675625585,0.09557391988506027,0.6967044957001925,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22777935178850686,0.08109723933263274,0.0054386794327308165,0.06791909394550388,0.38763960963150984,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11122828773216765,0.270258777348247,0.13931314813151582,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14800886783955872,0.10750851888978555,0.17005173345926136,-0.06391375358961313,0.35993148926873053,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08262653065014132,0.04013435552397753,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1381471319754216,0.07584341487350021,0.06994356745693864,-0.011356697712808866,0.2876509616636521,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08436032279837204,0.06785824174884886,0.6114670027237653,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13446227000565056,0.08315229284279452,0.10735224314522496,-0.02944894427827574,0.2983734842895769,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08700067179487646,0.05920707452851572,0.6950751273138628,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1047595988111055,0.08293806568238977,0.20793835993638807,-0.05872932724968155,0.26824852487189255,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15981448170349769,0.2355053858697489,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037852193580399436,0.06786747213758756,0.5776125137710155,-0.09592932209570706,0.17163370925650592,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16338238356980694,0.1332399132477928,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09806484338059357,0.07945107249647111,0.218465145200978,-0.0585504623894785,0.2546801491506656,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11706552620538871,0.15888795086341753,0.8332532350933084,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21086703958266212,0.08038847581346775,0.009346196413017158,0.05240390844650919,0.369330170718815,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1962568527363638,0.35639952178115575,0.1983417068376634,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11647253572814088,0.05916750695394335,0.050311216973618976,-0.00015946056940796538,0.23310453202568973,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08530451474133145,0.07548212913741022,0.5275612089369318,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1661661599043346,0.07483343450253484,0.027444771881363322,0.018653220705688617,0.31367909910298053,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.22732052655450138,0.3418567133934307,0.39228691037577734,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10902774608945848,0.0641220538283076,0.09053799612513172,-0.01737073729629396,0.2354262294752109,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14149287958367457,0.22670071376703074,0.6632964530955446,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11842201480572388,0.07036033897639729,0.09383180939332798,-0.020273482393056194,0.25711751200450395,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.17398772938577822,0.2540661858888578,0.6707240267079618,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14012084644032866,0.10381573437996493,0.17854936162958693,-0.06452249533941831,0.3447641882200756,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1369072338652258,0.23825487934223336,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1459665493075612,0.06963002138462643,0.03724035457684279,0.008710666570241499,0.2832224320448809,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07764875309027938,0.1837787422663668,0.4631727895701855,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14304610981604715,0.07141702031416243,0.04645412822448705,0.0022676643874245395,0.28382455524466976,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15580290114458703,0.26057376404354454,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016359971399990368,0.08814424097674292,0.8529323508891914,-0.15739145597132245,0.1901113987713032,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1229141261674975,0.09450307124538511,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08029283601752313,0.04509215982282874,0.07640353756365066,-0.008593596557681604,0.16917926859272786,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11469805429227721,0.13454323690535253,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011018586949839804,0.08796884327616286,0.9004399266405377,-0.16238709349012814,0.18442426738980777,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10703276724241108,0.0853856157574439,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15575435161122125,0.04975504490043409,0.0019915306084857566,0.05767636064349384,0.25383234257894866,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10538507889467345,0.20101332069714847,0.06374504020225781,0.6091919251481692 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09793916968137516,0.06380809884453502,0.12629896468805962,-0.027840440299191152,0.22371877966194148,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0902748878457662,0.14578027804271068,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08142296977663732,0.08674587777013197,0.3489848356930121,-0.08957198025208557,0.2524179198053602,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1643430725335709,0.2648399515210527,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22387764008200126,0.07097919686870512,0.0018433314556921738,0.08396223967755562,0.3637930404864469,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12346485085959594,0.2873665063121681,0.06021549421927768,0.575461129694149 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11567219394184391,0.03621703273183128,0.0016176420275150732,0.04428056287692156,0.18706382500676627,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1675206826763995,0.22742071016032894,0.053503510060061044,0.51131674232623 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1510619678898213,0.049608112127581094,0.0026207694193088648,0.05327361330364225,0.24885032247600034,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.04098930600897466,0.10773344308923129,0.0785044062282029,0.7502426888590925 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19639445433385616,0.05769964335985012,0.0007947324477512452,0.08265593572508086,0.3101329729426315,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16914679880353956,0.3232473652579813,0.03004088652499707,0.28709159861307076 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11071893522545662,0.05472713737380446,0.04431749639313494,0.0028398709862694355,0.2185979994646438,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14240454105154227,0.19463244866756002,0.5034452685637203,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12338633698156379,0.044775210285559294,0.0063668441773957404,0.035124680726343185,0.2116479932367844,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10214276384346843,0.14865836214604541,0.15361704887588873,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07660673126811537,0.07637271758308903,0.31697344377033865,-0.07394046892604328,0.22715393146227403,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12916224796953088,0.1467648522174411,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12739412332573097,0.048757351456092196,0.00962281124536637,0.03128280264879593,0.223505444002666,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1691622576635582,0.23100425859021465,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06368461161185951,0.047506389387639604,0.18150188774517284,-0.029960791353692007,0.15733001457741103,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0004970641474803449,-0.07510776871070401,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16113507593061321,0.057128757898071286,0.005249034694861685,0.04852189645631154,0.2737482554049149,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.011098213928593306,0.016036465769381475,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10715205686954316,0.09068672255219835,0.2387029441237025,-0.07161115343739224,0.2859152671764785,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1806338804845171,0.23782798126733815,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14420668847288887,0.04681217226640912,0.0023400000030462447,0.05192973810710762,0.23648363883867013,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12433286005436804,0.20423799461843606,0.07171783793120112,0.6853855236132604 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08719322162748334,0.06213935553664267,0.1620235884237415,-0.035296933154993215,0.2096833764099599,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.052336802168810204,0.033865965366917904,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030404454173678888,0.08428108479246818,0.7186450765776771,-0.13573185400506915,0.1965407623524269,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.140515396226328,0.11698787591375803,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07289561223639994,0.06541572353169671,0.26639340576627263,-0.05605297487728848,0.20184419935008835,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08571496767946031,0.17074755126694083,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1184131283464989,0.06821690049341671,0.084046355204546,-0.016057186449283986,0.2528834431422818,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07827714897084079,0.09824444214017658,0.6508877732816449,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09240416417967597,0.10952890967045034,0.3998154225828884,-0.12350108592833346,0.3083094142876854,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.030494291648605256,-0.049114288572500886,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08961929797486143,0.059657817849467554,0.13452777757721612,-0.027979207501381415,0.20721780345110427,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09690306783453563,0.09972679698638638,0.7462484265604064,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18171081486455198,0.08732962383370613,0.03865851565905004,0.009565174664304954,0.353856455064799,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.03342939438745178,0.036117401925160726,0.47356681682336305,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07519127039181464,0.051116996167308734,0.1427835219009502,-0.0255714220834347,0.175953962867064,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0651776091239687,0.03126301184853144,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15124893421561852,0.0808495770280406,0.0627583139571145,-0.008123127479206071,0.3106209959104431,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.040377794190700846,-0.0014514841899599118,0.5817074626033015,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056291544621684744,0.03612083412802574,0.12062451811461736,-0.014910458118832959,0.12749354736220245,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10398725395205297,0.12706318114995394,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03779897342257621,0.06286530176832068,0.5483030284398533,-0.08612217892197774,0.16172012576713016,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08178522154922062,0.04578158143391899,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058050006517209395,0.04908153328211664,0.2382424680462718,-0.03870034689034326,0.15480035992476204,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09628161855991217,0.0901873296430578,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0673732719352529,0.08666391728276684,0.4377843974517124,-0.10346011618641927,0.2382066600569251,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15267671228058768,0.137791854099558,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24244296117257866,0.09866782501450043,0.014807033057348337,0.04794726591308038,0.43693865643207697,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1398407267265988,0.2745839440273922,0.2647257396604304,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13556268842266772,0.07034077471504568,0.05528781636859767,-0.003094243371298183,0.2742196202166336,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16658779536976467,0.2027007370477625,0.5504031566140049,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10644009986514616,0.07403767575112453,0.15200840775021202,-0.03950422614483742,0.25238442587512977,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.052332700056960814,0.0485001881481121,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11051195828771243,0.06255014878583527,0.07870506906111407,-0.012787959136211655,0.23381187571163653,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10983846272502895,0.14273743905526384,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09827261940491648,0.07908674396749094,0.21539058207257003,-0.057624515770674,0.25416975458050695,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1590535387499687,0.12290305257612712,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12434784595784143,0.07221609668921296,0.08654885446853806,-0.018005752415604398,0.2667014443312873,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15304454357935138,0.20526263591143593,0.65578639613287,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1208374904466175,0.06547517944929122,0.06635261508092068,-0.008228297183329777,0.24990327807656476,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1436778237016091,0.19555172419624114,0.5971735357282861,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11723407246019037,0.06875085857166718,0.08962161002882323,-0.018288789583426265,0.252756934503807,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16218293860237182,0.21833080580635134,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15757640542539467,0.05851109542038323,0.007645243608893151,0.042238338710030965,0.27291447214075837,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.02908374779146819,0.07284737786187645,0.17308879679374334,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1374903989527829,0.04298885620935933,0.0015941933806925418,0.05275003424299862,0.22223076366256717,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.22248320262051655,0.26911179544586844,0.05294856508760417,0.5060133023244723 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21225895649652815,0.034548461786865624,3.9312508250199176e-09,0.1441564408649621,0.2803614721280942,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11026818914260712,0.2384700641211274,6.783971532393066e-07,6.483234875773957e-06 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18873112293260075,0.13017604806974464,0.1485880005634359,-0.0678741176484901,0.4453363635136916,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18166703322475,0.28412526456299864,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.23582510582008304,0.06949785985695683,0.0008240845883669758,0.09882974213450971,0.3728204695056564,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08087582259820644,0.22447741645482902,0.031002765224914946,0.2962839802493951 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09628194350744153,0.07300134512017,0.18862327458949923,-0.04761954993218191,0.24018343694706495,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16467912086199696,0.20268408614805203,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0945703029716082,0.05822770992962328,0.10583050951795256,-0.02020914944326077,0.20934975538647718,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12941835051232486,0.1081511385153366,0.688943585244993,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16856084336070523,0.08747868514059401,0.055331534262783554,-0.00387862902359154,0.341000315745002,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.04429799620354051,0.03571941970576145,0.5504031566140049,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06265247767221357,0.08785556449404246,0.4765492812241948,-0.23583486104970527,0.11052990570527813,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24843799636644473,0.04811408091528585,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.23156737766228774,0.09731713237591101,0.01822224097501494,0.039734190710697614,0.42340056461387787,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11662059323566251,0.2680622049586803,0.30645794249929786,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.33247668642266515,0.13415958077285012,0.013984821504747393,0.06801903840717932,0.596934334438151,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.23793601467149816,0.4843203857015565,0.2569710951497334,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035786970113235644,0.07726595013252158,0.6437204123976582,-0.1880949255049956,0.11652098527852431,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03054875272552381,0.10358342077469813,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06690397392591604,0.07973128592011627,0.40234817215772456,-0.09026369331198916,0.22407164116382125,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07201037073346844,0.08930899775233779,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08334364856357318,0.07624337726321255,0.27557887326438035,-0.06694859379163681,0.23363589091878317,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11302400883574727,0.1636196832549537,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06786006421779633,0.05751240338925828,0.23935413351602192,-0.04550936377551973,0.1812294922111124,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09393454164527146,0.1257582051843716,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06419356675333601,0.07207083605643497,0.3740993004640236,-0.07787369138952466,0.20626082489619668,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09170951593043279,0.09752401158829242,0.915842680969123,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04516394575762021,0.07098622597155456,0.5253093359154614,-0.09476531053394521,0.1850932020491856,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12663915962007544,0.08446269788640369,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021916707171015362,0.08455502959518504,0.7957320468982635,-0.14475960566334672,0.18859302000537742,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14119968537369776,0.09745677450682634,0.9735235918682278,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1502069375716917,0.05981556345189843,0.012779389218458797,0.0322974812802828,0.2681163938631006,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.17445375503568022,0.2498477316407864,0.23981747426980124,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1815690765604142,0.0689453799326699,0.009073161823236033,0.04566277070068542,0.317475382420143,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13472744375381554,0.27299985346664396,0.19636616606057228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.186357896831872,0.07913099976554429,0.019433192913850206,0.03037352387425496,0.34234226978948906,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06384987624125725,0.2070468966012131,0.3180632687631813,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20690754322563376,0.08015904789539736,0.010519753986702532,0.04889666430473419,0.36491842214653336,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16462260233437495,0.29404900356396835,0.2092877372091346,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07384952733570352,0.06611197651105129,0.2652428405253432,-0.05647152549592452,0.20417058016733156,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1362359131301792,0.1250801048247038,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17419136685941355,0.08525925251648299,0.04228182523075879,0.006126877821964111,0.342255855896863,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.055625031969935484,0.07492604579737407,0.4935781304143577,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09918490089697182,0.06625438676714508,0.13587239955934402,-0.03141687345422933,0.22978667524817298,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18701618647950743,0.19616731254943331,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2802341837636123,0.0840518179715933,0.0010101069341321523,0.11454981024258518,0.44591855728463947,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.021765307652689584,0.18044258950600156,0.03644649474155011,0.34830804445427466 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2655287700833022,0.09985849757911601,0.008434286968431293,0.06868600080806189,0.4623715393585426,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11123262341149584,0.2753828851111648,0.1877705709914981,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18501034964500454,0.07252906837242902,0.011451389756065319,0.042039816165158034,0.3279808831248511,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10144802866567496,0.27615556975423644,0.22274190244438216,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19974984375463667,0.10651047480352113,0.06211224977728624,-0.010205416192419797,0.4097051037016931,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.2122145597252499,0.42324007866137964,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061432899812703945,0.09033437117926821,0.4972076685203446,-0.1166357494735176,0.2395015490989255,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.05623272155177219,0.13741531144798072,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07172594697272902,0.2983124242921201,0.8102222774659563,-0.5163125788457487,0.6597644727912068,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16935763700590234,0.003194424162155244,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0926596698136916,0.07806297742386444,0.23656146345734166,-0.06121939933422689,0.2465387389616101,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.2052968782000126,0.2954795017842424,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10301791853192516,0.06585181720495632,0.1192174937237606,-0.0267903038495563,0.23282614091340662,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.20121693647432395,0.29507238092636673,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11690585141506774,0.08551420926803077,0.17304407278563555,-0.05166121270849619,0.28547291553863163,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03682028457512035,0.0077889131271867695,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13923422960925996,0.07564001900950867,0.06705604940142063,-0.00986866269158887,0.2883371219101088,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18608886945528846,0.300636497088881,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0761648607288649,0.086293191595099,0.3784365439745526,-0.0939377466102886,0.2462674680680184,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0827700426018416,0.05007890071725026,0.917821352297586,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08756349739849292,0.08769537585594381,0.31917712808854887,-0.08530311941036214,0.26043011420734796,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.05721055214142183,0.007596134225807451,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15494812667807156,0.09533103699859369,0.10556958060358711,-0.03297003527721162,0.3428662886333548,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13680157723314676,0.3062330948133067,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051134104800304524,0.07976527584072363,0.5221779064330947,-0.10610056394735695,0.208368773547966,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16602872307338748,0.19436732953650837,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11827257247151854,0.04348213479359188,0.007069244329432579,0.03255984862457044,0.20398529631846662,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1539271205545013,0.1714555826929609,0.16360251162401113,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15613327190312196,0.05931319760646989,0.009103394949646083,0.03921408771274386,0.27305245609350004,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.037957849250501,0.10343418995120846,0.19636616606057228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3306786488250715,0.09223242771379843,0.00041792020495996394,0.14886851820720978,0.5124887794429331,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1820539717652883,0.4020318262593765,0.01746026624722207,0.1668624441210733 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15454399604273988,0.08674040196609736,0.0762322334770754,-0.016440159987912623,0.32552815207339236,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09564314767203523,0.11398594038134167,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11209449335231528,0.06553078783346587,0.08862480034763205,-0.017080910470557265,0.24126989717518782,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15833882422614778,0.16882013834778195,0.6599471530576952,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1629678365876024,0.0817949497949485,0.047610577817458775,0.0017322400114512526,0.32420343316375355,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14921256456489676,0.1997916893309696,0.5170078888029929,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14528643570623068,0.04946987143196617,0.0036816819718957887,0.04777058353107398,0.24280228788138736,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14909889394658915,0.200128815965674,0.10218598424093975,0.9765603137966754 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22910757270527773,0.16362667973679418,0.16291979767359482,-0.09343612209831223,0.5516512675088677,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.022004482899004457,0.036761629083094494,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21442880521095925,0.08409570032436987,0.011484091065524834,0.048657930049588405,0.3801996803723301,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.22338373516113327,0.38199710889149446,0.22274190244438216,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04664042557058741,0.03742437353343158,0.21404504575230854,-0.12041198736356525,0.027131136222390426,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10659176799989074,-0.03845641121321204,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17784967258433032,0.06778083262752976,0.00932516281446093,0.04423894218440841,0.31146040298425226,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08070188442891968,0.19524831680290108,0.1983417068376634,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03905043927980932,0.07346715966085379,0.595603911116408,-0.18387015426672,0.10576927570710133,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14758352395790664,0.004742545932897642,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24466306752030054,0.10794202146915616,0.024422880428374167,0.03188591843169078,0.4574402166089103,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06907008392129707,0.2619006309358749,0.3691320687802387,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17655568361698754,0.08327285361981286,0.03515108418500934,-0.34070454935561817,-0.012406817878356902,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15320083340211396,-0.1444074233893024,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13068576639020124,0.07142959467410273,0.06871809572947156,-0.01011746583065759,0.2714889986110601,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0881313437470271,0.15736725409083932,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06533477719331132,0.06428976351561348,0.3106664800661704,-0.19206385276784987,0.06139429838122723,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1369974911263818,-0.032513176162833946,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13612073200559816,0.07189668831010626,0.05968234359037534,-0.005603243137002806,0.2778447071481991,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11382660499806925,0.2093042092176627,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013142055472063825,0.05816482174839591,0.8214618129892387,-0.1015134306900817,0.12779754163420934,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09188166379618506,0.02633130194896677,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2141004284921208,0.14960936769947927,0.153884585443779,-0.08081210235334774,0.5090129593375894,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15100857109297655,0.3372263467915774,0.7711789647234355,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023916070776007922,0.06482844533149805,0.7125605721323715,-0.15170700511036733,0.1038748635583515,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07462453376535513,-0.005936594102734029,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08114572347874278,0.04902908834120166,0.09939342834465098,-0.015501249569056297,0.17779269652654187,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0873497089830583,0.1435470690049261,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011016633862989861,0.09464487545837852,0.9074459726729428,-0.19758222251684615,0.1755489547908664,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.19287557155569768,0.050360590656881664,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06687885512423931,0.07621310056829009,0.38119523952836676,-0.08335370529485585,0.21711141554333446,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03745986797027291,0.054624946527555014,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01836390625304316,0.05541518913423473,0.7406790781900476,-0.09087145732181642,0.12759926982790273,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08750135423447115,0.06649903800970806,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16009728940686543,0.07517082768611737,0.034342672046544995,0.01191927502482451,0.30827530378890633,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09300535081029258,0.193652976770366,0.44600863216872333,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002292442509221308,0.06297259101004601,0.9709946275590022,-0.12184020021388478,0.1264250852323274,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07653265689286105,-0.015045315318521463,0.9972922369220661,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13838346475609722,0.08761466889463645,0.11572249839606807,-0.03432406111759789,0.31109099062979234,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08198302317468113,0.16935321078485574,0.7154246045700844,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005202371855293906,0.05114761466958678,0.9190807037201446,-0.09562067633254462,0.10602542004313242,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1006203547695243,0.06680142902381402,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20142392386770636,0.13223874940483135,0.12920298305056915,-0.05924734867690884,0.46209519641232155,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1071715886252657,0.19129558066355376,0.731539728822366,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021008476765528823,0.07443907303997709,0.7780472520865319,-0.12572709040903074,0.1677440439400884,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.054238294073187615,0.018262698122749017,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01992949547211409,0.07455143021101078,0.7893429919811169,-0.16644791204963372,0.12658892110540554,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05386640281729616,0.04812382022864072,0.9727286373504853,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0487886352611914,0.09404709392634272,0.6041814786818105,-0.23362253109394812,0.13604526057156532,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.005593542971741673,-0.06140063398015494,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005338416144894929,0.05228451657715034,0.9187209646991963,-0.10809492341407022,0.09741809112428036,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04199687947982514,-0.03058415722261654,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12258535367726109,0.10040132650524682,0.22275304363061427,-0.0747367277394767,0.3199074350939989,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.1267671455834893,0.2439606062946997,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06343922011175394,0.07397789528370904,0.3916085916022982,-0.08195200911117966,0.20883044933468753,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08113092407233745,0.13127747287407535,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04931182905131223,0.06235409507636369,0.4294631886857072,-0.17185841537238306,0.07323475726975862,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04516181353808219,-0.06398394298270553,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07337744142252146,0.08080187693007845,0.3643109125154771,-0.08542518692112856,0.2321800697661715,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0667637581832432,0.1266969342153839,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01807080193677413,0.055934971474833776,0.7467961456860939,-0.1280016701790704,0.09186006630552215,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.006934733223479033,0.0040074099845123475,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019679535319853725,0.04758458283654267,0.6793894958273172,-0.07384003514282435,0.1131991057825318,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04747252295250844,0.058136800023040704,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04922362415126063,0.09275795432024644,0.595915185536265,-0.1330766825431257,0.23152393084564699,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.11428229315838744,0.14033126269198648,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0002382454412657737,0.062033299820749226,0.9969373764338532,-0.12167787124608809,0.12215436212861963,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04138448325365706,0.05983976172071373,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0855078381497308,0.09116727317051947,0.34879529298450873,-0.0936662497360017,0.2646819260354633,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.12420713445019957,0.1861390011439732,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022122916341648306,0.07671448916038962,0.773190835068593,-0.12864663225748088,0.1728924649407775,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.052906879515409296,0.07569963357553243,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007007339643013608,0.055399581494004486,0.9899137424824352,-0.10817791446114437,0.10957938238974708,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03349061094911869,0.018235346171035987,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15520384579125932,0.088550709615484,0.08034328273757829,-0.32923551390217143,0.018827822319652826,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0772052458055321,-0.2061133253771246,0.6387525418536338,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03323613356479058,0.09887668551078374,0.7369265497100805,-0.2275617870964345,0.16108951996685333,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.20086105199941942,-0.16248226705978036,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04691690153971958,0.05046017094272899,0.3529909178917481,-0.1460879613816764,0.05225415830223724,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03427568296383212,-0.038789863906054926,0.9092831415853414,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026159828151939412,0.05599818086951024,0.6406186968207384,-0.08389526762555781,0.13621492392943663,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05053973475298157,0.09656014538165629,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02162673270798449,0.058435571871868625,0.7114883278845008,-0.13647211445632146,0.09321864904035249,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.050956509605683625,0.017971548903560456,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0022334810672688457,0.05921136814352818,0.9699275408848542,-0.1186035611478655,0.11413659901332782,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.014224510820397399,0.028103837416301108,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07205858583599085,0.09205594218901146,0.434180699493389,-0.2529792046344424,0.10886203296246068,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.015538490756099895,-0.06289010166491515,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05040250876964521,0.08559584043308777,0.5562667421034385,-0.11782185621411025,0.21862687375340067,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.02135519783462739,0.0876190727399239,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0670731839970741,0.04131551222195935,0.10520707230268801,-0.1482719405295354,0.014125572535387196,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.08792011334519742,-0.1507311420040169,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0735955332791266,0.07574897613745751,0.33179402806379166,-0.07527646031797808,0.22246752687623128,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08715423825344348,0.14485553361730702,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023349145937244666,0.062297709852665736,0.7079889982067789,-0.09908662461984671,0.14578491649433606,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.014566250197513168,0.034549776325576535,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006535933696585472,0.052014580928321494,0.9000613967596545,-0.10876192741649306,0.0956900600233221,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04775105549149319,0.06204962807120753,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04024371422412574,0.05459225308469357,0.4614098493002249,-0.14753569315368817,0.0670482647054367,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04864320942080799,-0.07775418894435997,0.936984237335683,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02553741698036893,0.04427566263109065,0.5643795124631974,-0.11255385601133658,0.061479022050598714,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0524537396669949,0.07298483320770408,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06647957183151432,0.06277886332598183,0.29020036370298624,-0.1898609693851839,0.05690182572215527,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0026486909668330724,-0.05941990004429443,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020125893144116565,0.04124962014421668,0.6258585639256353,-0.06094336348648458,0.10119514977471772,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09141314054843244,0.12479161752079933,0.9600126145781049,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04135771136472863,0.055150574867409825,0.4537097735921104,-0.1497469787475479,0.06703155601809063,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05774757085302897,-0.005144129757584753,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07181676612868809,0.08506874186675838,0.39900192081049435,-0.09537167443215191,0.2390052066895281,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.030119521232058764,0.0765272740909645,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10829533823062171,0.08295430563216528,0.1924064144868461,-0.05473753015447544,0.2713282066157189,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0597174094378885,0.1498549920150433,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049153945232957096,0.04308339288046292,0.25452693649085667,-0.13382717668895525,0.03551928622304106,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.018348551237360473,-0.04155076883025718,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006406233833828458,0.0992331531766933,0.9485555286372098,-0.20143246517896735,0.18861999751131042,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06583945840497477,0.03947891968400288,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07077062242024855,0.050270646009615505,0.15989392853434004,-0.1695692025790772,0.028027957738580106,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.054879521046973696,-0.0044867511358983965,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009976722091738804,0.08430178437579845,0.9058476870369134,-0.15570439128785662,0.17565783547133423,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04821242507288164,0.0644337925876315,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038245507510762854,0.058046635879949494,0.5103180150912625,-0.07583548533819681,0.15232650035972253,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06602075713148232,0.1359376036635848,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02135096151146573,0.0567994872498765,0.7071707326023077,-0.13298089149016365,0.0902789684672322,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.013750505913563452,-0.031911454515567116,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017472880328783053,0.03889628619759563,0.6534946733403362,-0.09391705112855442,0.05897129047098831,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04466303557043314,0.010678120107491454,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004472741231016708,0.056940611174945484,0.9374252413577309,-0.11638002677464193,0.10743454431260852,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.012582607655668937,-0.012965447421568849,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010369859375502085,0.051609063605361,0.8408447671737611,-0.11179887635214994,0.09105915760114577,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06079475044816778,0.031467323471489395,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011715744553401765,0.04670923648652629,0.9800006232425946,-0.09062764858008802,0.09297079749076838,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.037786827545984385,0.020399333735812052,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006302403558917334,0.04867400594715791,0.8970351013381286,-0.10196305365881375,0.0893582465409791,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05980753720967797,0.03444164169002772,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049815659441674855,0.0301955551000971,0.09969922849566501,-0.10915999272170959,0.009528673838359883,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.021326868523432265,-0.029093164303395518,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07860936678216313,0.045983270108514135,0.0880547709442589,-0.16898182384014737,0.011763090275821106,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.028282498794313052,-0.06551863450039487,0.659371665428829,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03020270247624817,0.056743938902275366,0.5948106576991985,-0.14172346143152,0.08131805647902365,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05071839558215821,-0.006552856906749474,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05740897305207124,0.031837475560996864,0.07203795925045517,-0.11998022747092718,0.0051622813667847045,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.024941616397790602,-0.04736638669951391,0.620887427285682,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0155042496123889,0.027027638875891435,0.5664996649947702,-0.06862257129603852,0.03761407207126072,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.037786831872988015,0.0031458077567116083,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020221493551946804,0.04591968798558614,0.6598864531101098,-0.11046899053944441,0.07002600343555081,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03364500650215463,0.00824293857133758,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02515272977627313,0.05192360772226842,0.6283286602040243,-0.12719993081488473,0.07689447126233848,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.11803152773331,-0.1826052220499325,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01232945563904716,0.041268647677654376,0.7652626291641005,-0.09343610771682855,0.06877719643873421,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.049198972462470424,0.07703898210487,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044246404682054194,0.09666158009190456,0.6473597099991889,-0.23421863752669259,0.14572582816258423,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0029068184539289724,-0.0435040560638137,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009361624148265538,0.06550689563662838,0.8864258318304967,-0.13810451474635982,0.11938126644982873,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0404923925635496,0.07259629053379597,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007833566370075763,0.05195809568192663,0.9879777768013718,-0.10133162474097253,0.10289833801498767,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08183678234854472,0.08474667485412905,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06173796562238124,0.0931021851242127,0.5075982887681643,-0.12123886937188597,0.24471480061664844,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.12783496448175782,0.14714178498055683,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07905671339586537,0.050177215737663906,0.11584337303092883,-0.1776716719196964,0.01955824512796568,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.019063085807855953,-0.061989306775397345,0.7156145487311385,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09651747616068039,0.07900176059687354,0.22246589944765185,-0.05874732341093945,0.2517822757323002,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.1374163525742138,0.23438779496801543,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035980744054146994,0.061892841782134785,0.5613074319664884,-0.08565932575717614,0.15762081386547014,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06642759376326939,0.08616137913195591,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007983086362569232,0.06010987082030971,0.8944053379055266,-0.12611902377306655,0.1101528510479281,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07186757996569718,0.04179536357603916,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06303616308261573,0.04302278164814135,0.14358087988930623,-0.14759027325869434,0.021517947093462872,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0005389630016246282,-0.06321490660926377,0.7623712538871658,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026744268750278268,0.044359395638339204,0.5468838928013684,-0.11392527105793433,0.06043673355737779,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.009841713661111064,-0.033122422603905,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012319279950762633,0.05487172818871102,0.8224635995069639,-0.0955219607380655,0.12016052063959078,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.01876832117598058,-0.0038132083310647214,0.9796489133048895,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05399485702561346,0.07029113177831371,0.4428012272931613,-0.08415065270438238,0.1921403667556093,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06420725513036102,0.11947690053014436,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001984371037897706,0.05923054858943879,0.9732889673124442,-0.11839214708966646,0.11442340501387104,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0026885531317478437,0.00799365542715944,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017347815364549015,0.0535168761111833,0.7459729411565986,-0.1225263199994308,0.08783068927033276,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.011351160578172,0.0024393178863823233,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027452330368073655,0.057841042026830346,0.6352940039306307,-0.0862246020124037,0.141129262748551,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03512559269285195,0.05592047528370336,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05269108571492359,0.05580385752097284,0.34557221186719245,-0.16236427132314366,0.05698209989329647,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.021288430296913036,0.005234912716697157,0.9073272983575541,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09499034876927481,0.08035413010435676,0.23778173357773352,-0.06293230777843956,0.2529130053169892,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0012942930515277837,0.10225405639992897,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05394946414235795,0.05606943218562764,0.3364789154648542,-0.1641445925119468,0.0562456642272309,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.011084263050756228,-0.05564183622243085,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005940224598657904,0.060918889015968064,0.922365184914715,-0.11378570330128757,0.12566615249860338,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0919781497800486,0.07674243161436886,0.9911128933864998,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026461801147099933,0.05607337744019916,0.637220666071415,-0.13666468325731024,0.08374108096311036,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08286505522957947,0.040098637277192366,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0100473513291611,0.05437574925030234,0.8534890345656836,-0.0968191253812195,0.1169138280395417,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.01902968150378569,0.01008041144658415,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006376820541076604,0.08701269457558888,0.9416115347199954,-0.1646321352264235,0.17738577630857671,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07250528208593136,0.08274010573641975,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003174409795033175,0.05562237292340573,0.9545145791005765,-0.10614209807013784,0.1124909176602042,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.012603216603348401,-0.019108812835492667,0.9946097045025434,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01232601323983896,0.07332449535865268,0.8665795497807903,-0.13178106728010988,0.15643309375978778,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.10520830443607526,0.08704836530974273,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04587371459626773,0.053060033521243846,0.3877468673397769,-0.15015437122590472,0.05840694203336926,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05349201894184899,-0.014643690489653229,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0009500300827874522,0.0525792045306813,0.9855923006644863,-0.10428569743264285,0.10238563726706795,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09678249790223836,0.07786903602803917,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043349154861125005,0.05796682025069951,0.45496128488825716,-0.15727328338725755,0.07057497366500752,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.027657597912273336,-0.04633036918416425,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06144890669212977,0.050318863204955114,0.2226634996010147,-0.16034224971590913,0.037444436331649594,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03423397934302548,-0.045941081076732025,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009889591791299479,0.06634026227171337,0.8815632754211817,-0.1402703256803351,0.12049114209773615,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06182481323764023,0.04278434788854965,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029976694625224228,0.05362744426014278,0.5764574954290441,-0.13537250253736838,0.07541911328691993,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.029573701957922825,-0.048747611059765265,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028377764808429275,0.0433740951264503,0.5132863468247784,-0.11362232310090856,0.05686679348405,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04458413384264039,0.008369977523568372,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05498020276354842,0.037871375751650116,0.14727576368845482,-0.12941008282136274,0.019449677294265895,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03658263777565033,-0.05634346296220288,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014352690829561452,0.055702748917378385,0.7967845253363606,-0.12382716432107103,0.09512178266194814,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.021221661516585312,0.004255392946683575,0.9738068609884574,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007899433821294651,0.05427750284008244,0.8843523897238774,-0.11457282357923046,0.09877395593664115,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05063547482591824,0.049986242530623066,0.9880940960671373,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03985787275721828,0.1125738127791136,0.7234624502705965,-0.1813872026196695,0.26110294813410606,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08820721399283911,0.08668402577339533,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0048634825490170815,0.058890408222822675,0.9342185847666,-0.11087580427605767,0.12060276937409184,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06223783198723628,0.08932881281852711,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04299437296958941,0.07808728617092021,0.5821897164454274,-0.11047317945986188,0.1964619253990407,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07478879514708757,0.11508634558997867,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06972717674231939,0.04004858398323645,0.08236646970941336,-0.1484359968787971,0.008981643394158328,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.01680178649951338,-0.08514572514448544,0.643528579284767,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022454211657100823,0.07935880202598042,0.7773508196784887,-0.1784207166781969,0.13351229336399525,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07930426117860306,0.04283435157056887,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032517275055709456,0.06119993052327273,0.5954573724674965,-0.15279554321963496,0.08776099310821606,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06127286490303243,0.015852905080793706,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015902395004879636,0.05286597453553823,0.9760163305229347,-0.10548950552195353,0.1023090265209776,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0384044589623472,0.048536127652934254,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012614119256791123,0.058422897895562154,0.8291568610138492,-0.12743459241605196,0.10220635390246971,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0575555769883814,0.04985724748480146,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0022525780921264548,0.07694142424339015,0.9766572277464451,-0.15346812979184024,0.14896297360758734,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07517835052606822,0.06911362456893073,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001713203550056981,0.03879996758856525,0.9648009325571019,-0.07454166906935572,0.07796807616946969,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.03436142343599586,0.00464167308029582,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05481209849572457,0.03430653051049569,0.11081916005024066,-0.12223586909863657,0.012611672107187437,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0495689673099714,-0.05804667362949306,0.70150119017449,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061484828029092074,0.07843376373922142,0.43351322440163564,-0.09266366834125256,0.21563332439943672,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08472873300450384,0.13500255339947204,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012164070545007722,0.04775955654595306,0.7990776710367343,-0.10602752268470986,0.08169938159469442,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.056260166539393724,0.051223151189511235,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026785744631074103,0.05723328041139398,0.6400076388543656,-0.08569673354110316,0.13926822280325135,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.02030757987624529,0.012978261482339817,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04959092331191143,0.04311067937429733,0.2506341268009483,-0.13431778182589163,0.035135935202068765,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06839104878880023,0.007433325078515384,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06660281158516836,0.04802074732805144,0.1661516850135521,-0.16097959069538442,0.02777396752504771,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.018780363615590927,-0.05334236631385044,0.7840604855201315,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008494236686987996,0.04615072640288306,0.8540551261989177,-0.0991958011950564,0.08220732782108041,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.004548273325369996,-0.027159798499267165,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11858064128089611,0.06277909030795188,0.05956411934619191,-0.24196248492981498,0.004801202368022756,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.10553839853584206,-0.20850796200668506,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018761644839136882,0.04749589026660229,0.6930210773192653,-0.07458361515259417,0.11210690483086792,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.024142124228622656,0.037307181609830604,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08246564747492552,0.058883915823618946,0.16207014306586653,-0.19819217457093233,0.03326087962108129,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.10048655044227874,-0.14457188146622577,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005384614528270153,0.04201071339388291,0.8980706950490946,-0.08794967315077548,0.07718044409423516,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.015343601901911013,-0.001216702868353025,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0812641292987474,0.057483420056001565,0.1581532505316191,-0.19423821527170637,0.03170995667421157,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.09556528026069751,-0.14876126423154026,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019853929152304987,0.04672414901143366,0.6711028050158699,-0.11168246027116518,0.07197460196655522,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.019607250411634223,-0.0421626514797967,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05905661031087564,0.06441101638102713,0.359708963671556,-0.18564573279430893,0.06753251217255765,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0031255294487447373,-0.08417547710721056,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01720516840339128,0.05118664671273675,0.7369349174033835,-0.11780399534789993,0.08339365854111738,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04117622892762905,0.009749778418673891,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02005882941112982,0.04935360448049379,0.6846222937901416,-0.07693745839190583,0.11705511721416548,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03890676622043462,0.03650777423886315,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04314185809200311,0.07508707583888113,0.5658821060972589,-0.1044292807340381,0.1907129969180443,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03666990361550165,0.08926209015934038,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0876687606960453,0.05880274975922264,0.13670058711080318,-0.027898248021822877,0.20323576941391347,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07154147656788375,0.15228885391487762,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016999209965769153,0.0482047632134914,0.7245216738102475,-0.11173764164366179,0.0777392217121235,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.022628705744997552,-0.03675611741885334,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02342412290466098,0.0419157811687294,0.576554793421401,-0.10580260805336031,0.058954362244038355,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06084516427721742,0.03457737514674684,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03390289164952924,0.05328944139192702,0.5249728047649854,-0.07082862793294155,0.13863441123200004,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03189051054002253,0.04804223012811237,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04076864756229904,0.052624623354123386,0.43892628780057574,-0.14419357804332056,0.0626562829187225,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06233213044496836,0.014927684050102197,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022725350669835456,0.05541715118815752,0.6819470205704394,-0.08618782806253755,0.13163852940220847,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.023641047045715763,0.01942866439872398,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022292669945162394,0.06277467608279982,0.7226671897057133,-0.14566583816990944,0.10108049827958465,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0662839946639342,0.037982861033187126,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006500694118365836,0.05133602165976814,0.8992904938259672,-0.09439170440020175,0.10739309263693342,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.025335954331211427,-0.00022723435096527744,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04143360561434801,0.0747448236777568,0.5796299332712452,-0.10546489360469657,0.18833210483339258,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.11676558730453884,0.1501385220316009,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031535437169219804,0.060523342667573976,0.6025951737646902,-0.0874131102769143,0.1504839846153539,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.044823330741213814,0.10883129954032278,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06620764536898814,0.06768954648754985,0.3285550425396536,-0.06682488186938827,0.19924017260736454,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06263946962060897,0.09539912910049449,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027714341276383656,0.0775356379219698,0.7209326315351576,-0.12466903841868542,0.1800977209714527,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.011269420190656585,0.06725194167600104,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06741710385615553,0.06142953962171906,0.2730319633957458,-0.05331242274024979,0.18814663045256086,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07071514656561173,0.13666223290688928,0.8700354117066056,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04366472498087911,0.05059851878669426,0.38862393105534765,-0.14310768446282043,0.05577823450106222,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.026638502856291473,-0.027702005239151065,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05238902419819325,0.03747722825508466,0.16284578608908407,-0.12604427301243104,0.021266224616044542,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.11552998477312648,-0.14762830255663736,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010756202428581545,0.06947492037790333,0.8770326548949877,-0.14729758462350315,0.12578517976634004,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07104018012715144,-0.028832666289798487,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021085561707232848,0.05607529962534721,0.7070803414313914,-0.13129222155213535,0.08912109813766965,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0021049256715611705,-0.02836899457656147,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08713988634091095,0.07668282393859217,0.25641704183203906,-0.06356742953987594,0.23784720222169786,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.10566763263398143,0.19148187175901274,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053334284907991504,0.03727311384764814,0.1531624567732906,-0.1265883808577757,0.01991981104179271,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.06510733351434192,-0.1297708315975772,0.769983269073072,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04526719147525488,0.04939095033107222,0.3598992660850192,-0.14233687632616748,0.05180249337565771,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.01197847052167638,-0.0564774181013876,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00785573160326895,0.055376029556416705,0.8872538252127812,-0.11668809261889669,0.10097662941235878,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05366585466065764,0.054080230590768275,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00262962166753194,0.05579337751994376,0.9624297171826804,-0.11228221057958984,0.10702296724452595,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012649952245862676,-0.017433822005008877,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011063054147402527,0.04800635894477003,0.8178486758319703,-0.1054115552872358,0.08328544699243075,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04467415572274906,0.05158011136397452,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016119846836546523,0.053857453668531084,0.7648471175106106,-0.12196769992367391,0.08972800625058087,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.017633266657818034,-0.026095430718420163,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04304687509882372,0.04915960907134722,0.38169195297337366,-0.13966189724282355,0.053568147045176116,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.060056276350217826,0.0002806366295802527,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02613925149639239,0.09008515235318323,0.7718283874222716,-0.1509081081930746,0.2031866111858594,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09406728734995179,0.12752285045182382,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007958860873576942,0.05848395907938103,0.8918149395283927,-0.1069816178703141,0.12289933961746799,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03242420061581814,0.02990310535387733,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013896768765321917,0.04455459109485547,0.7552599944391766,-0.10146139522520337,0.07366785769455952,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.014033088943187794,-0.011057945308275892,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024557217558483536,0.08060613447751785,0.7607705247865941,-0.1338607116033399,0.18297514672030696,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04615440540849724,0.06534007340012028,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00970866723817018,0.05455721409963899,0.8588405491488977,-0.09751444840340234,0.11693178287974271,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0340842806346965,0.04207641871557844,0.9839047884462332,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05593039963143592,0.059844597672119026,0.35050673612014016,-0.17354498686094516,0.0616841875980733,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.024216889292096328,-0.0658563932012219,0.9088510667694087,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06430730526628334,0.08335821103299902,0.4408471836877923,-0.09951937189766305,0.22813398243022973,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09058021253260634,0.1353437537106561,0.9320838159679753,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02929851419725136,0.07967223027413545,0.7132441615160361,-0.18588101022617062,0.12728398183166792,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.07847399197492491,-0.1250161656321329,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030007849025112273,0.06853851478853903,0.6617268124975656,-0.10469318397946298,0.16470888202968753,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0033344535093813078,0.021785557181809138,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001991610674459082,0.0678143179531941,0.9765838520448933,-0.13526935544291518,0.13128613409399703,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03613480474075358,0.06573655518991141,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01674967482888854,0.06345273392052597,0.791925098878529,-0.10795610311844084,0.14145545277621793,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07471183988579655,0.08245018225513227,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01741401309270056,0.04391736628348148,0.6919140834878057,-0.10372628034093222,0.0688982541555311,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.053538879005880585,-0.07744549616078669,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006403133585649085,0.1258633819313268,0.9594491077398961,-0.24096037605424953,0.2537666432255477,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.24236146427730543,0.3328699380613985,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0351318925814761,0.05635498540455333,0.5333402553000924,-0.07562444306967911,0.1458882282326313,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08111150759666855,0.10409595832503411,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03831576881675376,0.05751503825740842,0.5056383643384765,-0.07472045746380293,0.15135199509731045,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08830857799527388,0.11283735444766874,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01061242152979242,0.052158904591087164,0.8388663728371735,-0.11312205936602669,0.09189721630644186,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.05553769961783432,-0.06867872167045286,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016776880640153067,0.05282565697106092,0.7509458819746517,-0.08704314792482432,0.12059690920513044,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.050577124337031716,0.05015636387168637,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022950798621027637,0.047900727988177405,0.6320807454026256,-0.11709169971271007,0.07119010247065478,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.027643114344576274,-0.07092521273481837,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010387359716271966,0.05482921847455829,0.8498274190549077,-0.1181450546436145,0.09737033521107055,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.042239864695830166,-0.05972258557340355,0.9829418698029807,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0025879453004950025,0.061536751099202466,0.9664735776916229,-0.12352817819556344,0.11835228759457345,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05044962632593212,0.029509464744072917,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04601629659985716,0.051500619317741164,0.3720694830541549,-0.14723218439489222,0.055199591195177894,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05694014305697548,-0.03534168098581867,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029407932899847607,0.06359597069640455,0.64400849926996,-0.1543952188683913,0.09557935306869608,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07629035047311827,0.03785057656305609,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03075357756759792,0.04319569200955982,0.47686469875027016,-0.11564751425395504,0.05414035911875921,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04419756047688203,-0.06769233402096807,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06937882223938295,0.09589158745254392,0.46974654528154647,-0.1190801183454538,0.2578377628242197,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06672416748785717,0.1378204038553659,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0044539687668535225,0.06355655605887688,0.9441625433490495,-0.1293637918314102,0.12045585429770314,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.018777772877232448,-0.027176620040347505,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13324352578779594,0.07468926091475112,0.07511263425900316,-0.013545774076746342,0.2800328256523382,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.038833727847479814,0.16311959882996185,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08761693936098114,0.07309552135466015,0.2312995996851758,-0.05604013089883664,0.23127400962079891,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.028082959578011234,0.1114888323298842,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009215701476984611,0.04775229390941276,0.8470554707667308,-0.10306488011444742,0.0846334771604782,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06340555492199239,0.05287209082810887,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10640510427236724,0.07820448294667118,0.17433162421511453,-0.2601029874407784,0.04729277889604397,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.14250640289165842,-0.2275351726573591,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01071470436295347,0.08793633353081988,0.9030761087526642,-0.183538918628201,0.16210950990229406,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08914156957598912,0.04362095461482431,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04722391107791397,0.04582295669572307,0.3033033287879261,-0.13728129882962462,0.04283347667379669,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.031403559375633,-0.045947815120426845,0.891229301693288,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03269584263895169,0.03938235904118187,0.4068641631743669,-0.1100953086380507,0.04470362336014732,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06726036741262724,0.03668906851722206,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013429636256392982,0.05864548447812931,0.8189769764920903,-0.12868756626305208,0.10182829375026611,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0012711360822240199,-0.08686567128211248,0.9783899072890752,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12316986638163094,0.04442292196013255,0.005794445046625551,-0.21047571909193935,-0.03586401367132251,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07965167092326864,-0.010065197592526881,0.1450987532495698,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045616452898906146,0.0668785374785682,0.4955453932742706,-0.08582217123808422,0.1770550770358965,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.02887922027404223,-0.06976022581035464,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02388411396591676,0.043368152374384863,0.582096840656875,-0.10911699276921284,0.06134876483737932,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.061035490313584614,0.036959128415064255,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014572682252964927,0.057232256552170443,0.7991319966668098,-0.12705314820040275,0.0979077836944729,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012359205807315945,-0.06246610363304087,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03677131817437012,0.05279206381309795,0.4864615446118504,-0.14052532498364623,0.06698268863490597,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04474877331905178,-0.009616053327680082,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028903768595209815,0.036843954528255056,0.43317106246455483,-0.10131442339625973,0.043506886205840097,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.017228625572695312,-0.04147202304779157,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0060675124418139124,0.04777101532808397,0.8989881950339218,-0.08781846002525116,0.099953484908879,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.050540995844015425,0.023600992077936395,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036403989042088,0.03164975166232395,0.2506762413290987,-0.0986063034109749,0.025798325326798897,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012251282475495687,-0.04391345377926557,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0222004685656434,0.03562328456176817,0.5334731126242346,-0.0922120998986368,0.047811162767349986,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.049708302205610094,0.023391720217274856,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017136088404021508,0.0922586700807117,0.8527339875768386,-0.16418295829318322,0.19845513510122623,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012843007291889898,-0.06759596657721764,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09198309595758258,0.05224893264619238,0.07901679461066434,-0.19466966893837728,0.010703477023212102,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05028750215332757,-0.018075507777080776,0.6348535583192849,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046804494878753274,0.03586502230170638,0.19256421219411352,-0.11729122146857171,0.023682231711065156,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.026556704994668758,-0.05034635732319868,0.8135043727497994,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06202724243775334,0.04896183921109661,0.20587502122175513,-0.15825358086785712,0.03419909599235046,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0617677449022952,-0.005031055269849648,0.8199879169384305,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007084425701699032,0.041274934999275134,0.8637990132362954,-0.08820343446272284,0.07403458305932477,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.016130888607413654,-0.017442762856897668,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01297206603551739,0.05459549038942026,0.8122986764966844,-0.12027040734821844,0.09432627527718367,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.023038957813054223,-0.00465386917142576,0.9762342004588465,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05225525880781558,0.04663041233993434,0.2630541677561005,-0.14389956611441015,0.039389048498779,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03227254954076276,-0.053784863630957476,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058910147583687116,0.04582163780094205,0.19924023855710812,-0.031144648100045767,0.14896494326742,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07186710482567447,0.16096925089483557,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10105587762129234,0.059467680272250925,0.08995693730445949,-0.21792969649192662,0.015817941249341938,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.05308663705551641,-0.17731498614838506,0.6623259037556665,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1661835882093765,0.33266487854726645,0.6185451949998781,-0.49423969575884663,0.8266068721775996,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08434922307381229,0.055055689389989435,0.9572656024379023,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022473349757694314,0.2192995566442132,0.9185933866954885,-0.4128913151393501,0.4578380146547388,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05739276899590818,-0.06562842502423405,0.9901822239590808,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00910639823734408,0.18793445360829894,0.9614552060837088,-0.38220346085717066,0.36399066438248245,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.01391692396334485,-0.030588841597428536,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18227757914416237,0.26154493758746605,0.4875507506775195,-0.7015099289524276,0.3369547706641028,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.21661111287752202,-0.4643844192862593,0.940275458344982,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08088256797723009,0.21298917834757858,0.7049788623285669,-0.503719548028358,0.3419544120738979,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1013172538326202,-0.21565270092955022,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10735865981974047,0.19165674596672327,0.5766880972317566,-0.2731280874400026,0.48784540707948354,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05239594879093289,0.15636174849788956,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11494385174848043,0.28931808512296864,0.6920431313025894,-0.6893128705722108,0.45942516707524994,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10381091141068985,-0.2740920493411368,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09532088512685731,0.17891487225219094,0.5954352752943447,-0.25987004455452306,0.4505118148082377,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.029043735010355724,0.09000519612095313,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021061639666669976,0.1684852659181508,0.9007830836284667,-0.3555471829071914,0.31342390357385147,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06519108891172268,-0.12612995478930086,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17731703941121962,0.26493819771744803,0.5049421029311056,-0.7032858622976992,0.34865178347526,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.19110538834972238,-0.42676956101420194,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015363887994521905,0.16253503500599936,0.9248899256130432,-0.3380367293455833,0.30730895335653946,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08219657432955532,-0.1308865074269204,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16230792979497793,0.27059777415256275,0.5500591989608987,-0.6995124324787059,0.37489657288875006,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.25131446918266337,-0.46427137568346327,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04897570699344935,0.18862757756614842,0.7957015142685215,-0.4234487946461528,0.32549738065925415,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.070170936418161,-0.16575190193049108,0.9735235918682278,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030798106859872273,0.1577779663667749,0.845654008858718,-0.3440269729211512,0.28243075920140664,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07468487605315555,-0.1380314435364199,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16388416604127332,0.2946732076270592,0.5794120686127262,-0.4211161151076175,0.7488844471901641,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.07087914102555312,0.3195573430448429,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0581757729384869,0.20434039409744403,0.7764934474138658,-0.4638427453779008,0.347491199500927,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.3334194514230534,0.2693210268989368,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006634229700445823,0.14269005409145455,0.963014123711216,-0.28990980277628636,0.27664134337539475,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06945775963445103,-0.12237842254346162,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09943564904705704,0.16505601113825685,0.5483193930456807,-0.4271132607945053,0.2282419627003912,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08180063908793726,-0.2283850162429996,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010983293044592989,0.20174933492393268,0.956698700909498,-0.4115063626596418,0.3895397765704558,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10098592534628875,-0.15789140553956252,0.995747388821315,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06272371610740728,0.12892691903794995,0.6277289498616403,-0.3186760115068454,0.1932285792920308,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05841131501799184,-0.1637381793856387,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056917395160863575,0.2748471370287919,0.8363847945680511,-0.6025579497589002,0.48872315943717304,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14314508563806957,-0.22227701460625707,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16616261343217012,0.24727729890562622,0.5032345386723371,-0.6570701192296062,0.32474489236526594,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0397135446631933,-0.2647574680306132,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011857719801939837,0.17502648389624229,0.9461285075028283,-0.3593292225976397,0.33561378299376005,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.008199030857544944,-0.02643999659404812,0.993077588787628,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21356215011825191,0.2876161075097089,0.4596013768922169,-0.7845523161773083,0.35742801594080437,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16106249707734757,-0.4354741475076511,0.9366557334939974,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1412339322202922,0.15389258584877405,0.3610772363789586,-0.44674934270919486,0.16428147826861048,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.031070452944668658,-0.22211120277371682,0.9134053709502656,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03204379999587127,0.1899616061675494,0.8664025272953827,-0.3450776692764735,0.409165269268216,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.026080725947442193,-0.015763818235181293,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06730525178648347,0.12347165418832683,0.5869574816137366,-0.3124274771687988,0.1778169735958319,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.013622477758171029,-0.10089862286006693,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08956152316817659,0.2111646404794104,0.6724289769537273,-0.32965329124922993,0.5087763375855832,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.009548288858952805,0.06915794444280456,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044348193289080136,0.13871603438753785,0.7498940791796923,-0.3197343397597548,0.23103795318159454,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04317689396555404,-0.12722534446241435,0.9644346245002389,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007216002025165128,0.19417499851080813,0.9704335261567933,-0.3927021126751422,0.3782701086248119,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08543738426054731,-0.12072902574350781,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010115932762004474,0.1142309676624212,0.9296205324208726,-0.23689307594565187,0.2166612104216429,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0992152996022167,-0.15090826729931703,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09542355470352219,0.3106177580326411,0.7593591991825208,-0.7120777705455973,0.521230661138553,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0670655894269189,-0.22906097288560218,0.9672325614747834,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13890682250240768,0.2781385345192902,0.6186410355891205,-0.6910816272714038,0.41326798226658834,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14563089464176407,-0.3453761508787776,0.9572656024379023,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047360090831920054,0.12827948652681334,0.7128043032038511,-0.3020270701889197,0.2073068885250796,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04875027770596413,-0.13953864620714646,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09126101447646517,0.23931317040847291,0.7037984083851339,-0.5663577261828515,0.38383569722992117,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1363390513433623,-0.2733258721514229,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11432852978477244,0.1260331186624179,0.36663285875891494,-0.3645359050847302,0.13587884551518536,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0871495531931126,-0.0736038827983718,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05425935049164213,0.18897944851376244,0.7746474956669717,-0.42943099029620213,0.3209122893129178,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07217077904298393,-0.1641350587583461,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007672450113436619,0.08750948918856895,0.9303190328537381,-0.18140075134161962,0.16605585111474638,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05386833859995228,0.006175815917550115,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0004348772967590984,0.10287172050219515,0.9966359175811392,-0.2046610636564588,0.20379130906294063,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06333520624167925,-0.07131229757775845,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020624618313437756,0.11794416915068637,0.8615557869970774,-0.2547733984778954,0.21352416185101986,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04723876830601545,-0.10281362385081275,0.9841643751662926,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006985221086166324,0.1550263401689641,0.9641554292176395,-0.3007809763046265,0.3147514184769592,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0455598490668431,-0.05843724594924578,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07361355360838043,0.12307535127676658,0.5511846504190936,-0.3179490182378272,0.17072191102106635,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08879654835459781,-0.19870999276722084,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02037763473494771,0.1490449709678419,0.891540354073524,-0.31626931291685373,0.27551404344695835,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.033480192082321954,-0.08103697230104585,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024368949789245968,0.11815806826912002,0.8370446012181808,-0.25894237339322373,0.21020447381473178,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07600057991908465,-0.12485025301649148,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023983894354010785,0.09000697513437499,0.7904570363617762,-0.20267033206235535,0.15470254335433375,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.057579131334553196,-0.08893455177946719,0.972929334907502,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0673595231495532,0.08866935424329697,0.4493323987609038,-0.24339044764157025,0.10867140134246388,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.007535722366665205,-0.09964026125801165,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030131480819135654,0.13600484685426112,0.8251419850564992,-0.30013523951867105,0.23987227788039975,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07158862685568998,-0.14656171518141797,0.9805354906255225,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012642504676388201,0.09012771955520067,0.8887411136357863,-0.19156865036734508,0.1662836410145687,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.033234976409543315,-0.04989485510268864,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0692636353658855,0.10791334788863398,0.5225196003884557,-0.1449714468220613,0.2834987175538323,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.029427368493726326,0.024879288618756136,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037225569477417994,0.12687353554169578,0.769851159884277,-0.2891013832303283,0.21465024427549229,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.038583255005381165,-0.09942619258120794,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2317618645762762,0.24553483278026264,0.3476119586655181,-0.7192101377497535,0.25568640859720104,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.40785526464893923,0.02485245206014426,0.9086350165348037,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08416405630240453,0.2417642344964133,0.7285169014429208,-0.3957986328442308,0.5641267454490398,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15333448109686662,-0.015701641566423584,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08045294982593104,0.3728657844926762,0.8296302564615552,-0.8206851226642575,0.6597792230123953,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11630120115151503,-0.21318981697431266,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0017663480573190896,0.1399502900423671,0.989956431797713,-0.27607010569069224,0.27960280180533037,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.035771860427621635,-0.06393676553136884,0.9991191172759399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00846504835459879,0.16627321100982287,0.9595037493953444,-0.3385591073685447,0.3216290106593472,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08612740848115602,-0.10981008510272612,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1630017753887338,0.1443119238106719,0.26152667643797706,-0.44949716695221176,0.12349361617474416,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14479695351114905,-0.377088897245035,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002796611830388311,0.20240995944690834,0.9890052957378149,-0.39903796328184066,0.4046311869426173,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10595331287656246,-0.09520093133646271,0.999046747647263,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1821172089630022,0.22165257170256691,0.4133427071101412,-0.6221531993659156,0.2579187814399112,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.12244615578042635,-0.3838157994895478,0.9263451842579509,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12164673949397266,0.20728842600950872,0.5586980155762145,-0.5331662952451901,0.2898728162572448,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.12492816497623291,-0.26517626488159884,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05851797755811437,0.10623454118702906,0.5830381120575987,-0.2694202070570021,0.15238425194077332,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09508283931751867,-0.20637451729349868,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03294994672330768,0.13013620295296574,0.8006639774397,-0.22540308078194302,0.2913029742285584,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0017221584338173472,0.019664811840952076,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03760013853162802,0.17006023676850254,0.8254899150782479,-0.37521239423330793,0.3000121171700519,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07891315248823931,-0.1531969734672139,0.980597249022118,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0686500601720581,0.20118685131470432,0.7336874697453128,-0.46805645863742884,0.33075633829331264,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0882484010056847,-0.18474531688450574,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09070333895951213,0.29963287627816315,0.7627689685121335,-0.6855498072750801,0.5041431293560559,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.02239475362680273,-0.2008773917400802,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025044056931696593,0.26808261325136246,0.9257672946812365,-0.5572553339123297,0.5071672200489364,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.050090213825135656,0.0076040614467656085,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027824003504529307,0.19817201897200418,0.8886386235020588,-0.365597196027084,0.4212452030361426,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.00393659939317909,-0.02747594001087339,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02341191661745771,0.27420906333270195,0.9321391275603198,-0.5677857347700189,0.5209619015351036,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.024488941216983133,-0.07728130955944068,0.9918526261485133,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07234088685087701,0.1947545794628663,0.7111322119941663,-0.3142958374657884,0.45897761116754243,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.012790304318680362,0.04664475904207902,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05317519627848666,0.16467110881925445,0.747467328534629,-0.3800886803108824,0.27373828775390907,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.028463680743658,-0.07307421871796134,0.9633699714089764,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030023903513291504,0.1943926053228786,0.8775827241811518,-0.35589421127871895,0.4159420183053019,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05165494267985692,0.06267707929331928,0.9858833377512005,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03838404047521401,0.12743915410180368,0.7639240356688938,-0.21461466809175386,0.29138274904218187,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10315661280534777,-0.0754491470377486,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.000525799131734046,0.1195126141304272,0.9964989210421349,-0.2377883362661711,0.23673673800270303,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08319732127316842,-0.13101966425046102,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05093832658138527,0.13778789826089716,0.7124389015998093,-0.32448188987525334,0.2226052367124828,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.018004794867319547,-0.10880782150339172,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10220518771690561,0.2320565873572769,0.6606246585900295,-0.5628957606388573,0.3584853852050461,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16712849329608087,-0.32441104755761385,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027416903107001102,0.1629084400540717,0.866707893378726,-0.3508310472044635,0.29599724099046126,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.07895842422353423,0.028424838853896572,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1489901542009105,0.17065572027137546,0.3848398692298839,-0.487784594124242,0.18980428572242103,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.24698603570382643,-0.4236340345812641,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01658084049848026,0.15482223008063506,0.9149386696544779,-0.290780147134631,0.3239418281315915,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04788662128058559,-0.053678153393111175,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025276232505234333,0.11762852882812941,0.8303200701044442,-0.25879838740258776,0.20824592239211911,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15943105181208242,-0.21182683075416012,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09946690751403647,0.12313214108773679,0.42122026220855924,-0.34391511417270093,0.144981299144628,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08406220821697327,-0.22810509795614306,0.9282753503874777,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039168683300724275,0.11097300511151084,0.7249027309300885,-0.25947795306078153,0.18114058645933295,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0937813328119753,-0.16588010610320628,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06629815873794902,0.13206730167114994,0.6168270659178378,-0.3284849019113502,0.19588858443545215,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.13377218663648027,-0.23701037596792948,0.9565097185496769,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02871701805049123,0.05878114317508236,0.6262923063981252,-0.14541234152624077,0.08797830542525832,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.01599482242116254,-0.07266347777275536,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055659171566458804,0.14408456122426117,0.7001418922791062,-0.34170319132710447,0.23038484819418684,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.021117766470368678,-0.10575551465439807,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044175023083444905,0.06226034546257574,0.4797390402260011,-0.16777743639185216,0.07942739022496237,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.03672611016949794,-0.1251839663075272,0.9384348204322319,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02060078892106841,0.12838141060563324,0.8728551067466725,-0.27547011315782705,0.2342685353156902,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04251418892127201,-0.09590161090304831,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042961537548397655,0.1344345088641325,0.7499943231342876,-0.30984778117718165,0.22392470608038634,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.053817625699125696,-0.12646139729137837,0.9644346245002389,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06406107749216666,0.2546905506406934,0.8019514187233167,-0.569685748735911,0.4415635937515778,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16799059219895854,-0.27568499089588067,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06675016152676225,0.18769106733742183,0.7228998082119731,-0.4393640413080897,0.30586371825456515,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.051700065659367446,-0.16436615971814933,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06918684111245137,0.14027926418105674,0.6230038877659511,-0.3476763910994249,0.20930270887452213,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11747248558810454,-0.21820512722955954,0.9584620018167673,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014738003078337813,0.16117776762814798,0.9273359671871605,-0.33471632800548945,0.3052403218488138,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.004292821465518421,-0.018415979773644897,0.9916764739841218,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08204913099399383,0.19587187181188837,0.6762407554431635,-0.47090396106776844,0.3068056990797807,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1076069442709993,-0.23983685902910096,0.9619311554974709,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012328465616962232,0.15294867279439273,0.9359254592912175,-0.3159699717674289,0.2913130405335045,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.051940554269782044,-0.09381230152183263,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06364928590173344,0.16009653684592126,0.6918404400449754,-0.3814810963334444,0.2541825245299776,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10282323647033684,-0.20128871537041784,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05832650730769415,0.1718458454646596,0.735048714988753,-0.3994836444652946,0.28283062984990637,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.01722751133862348,-0.09605986562457053,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.113758357624018,0.17769802957107486,0.5235979564425528,-0.46653354915159984,0.23901683390356387,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14590983035624344,-0.30319655438247295,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017127425115583572,0.12681992129325412,0.8928556163963552,-0.26889680112797265,0.2346419508968055,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.007179769237497498,-0.030811946238501912,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017374944856399746,0.13957613902112473,0.901195383400935,-0.2597187252012262,0.29446861491402565,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02800747171422419,0.03629831223431313,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03436417859045082,0.15085499591127421,0.8202943228290129,-0.3338492106076825,0.2651208534267809,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1311294888526834,-0.20953905150264346,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0617991410887247,0.1671256984864682,0.7123721268073546,-0.3935856017211598,0.2699873195437104,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0580380741081963,-0.16497228942765974,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024256353981424998,0.12625076363292975,0.8480517405259751,-0.27489580917750017,0.22638310121465016,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.004574853168344059,-0.07343882882942121,0.982606147466821,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025429490573521875,0.14066603338686648,0.8569260110066197,-0.25382789336741185,0.30468687451445564,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06059567511726386,-0.05512392815715471,0.9836246458712524,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007282539269120314,0.0610995761397104,0.9053754667267052,-0.12858053411446646,0.11401545557622585,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07148593300092652,-0.068092319589151,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0532234759473093,0.16477343106673478,0.7473975112581543,-0.38034009532419666,0.27389314342957805,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.03175539034749084,-0.07028657791787132,0.9633699714089764,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019979015975838236,0.18297613838749033,0.9132827445012971,-0.34327454637616317,0.38323257832783963,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.06805214671353495,0.09958563822314279,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03286904461083318,0.1870202493056635,0.8608634443070171,-0.4041511822214403,0.33841309299977396,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.022345931439917147,-0.06501947406146757,0.9841643751662926,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05460516614680709,0.19539841117949214,0.7805027738561887,-0.33330972573138073,0.44252005802499494,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0793840752243788,0.12715467434446498,0.971254274787651,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058484607883112355,0.15472211315080017,0.7062755592442931,-0.3656468382808007,0.24867762251457595,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0696062106570772,-0.03864404117409072,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033836981544951766,0.2055743734025941,0.8696106925882215,-0.3742797495483209,0.44195371263822436,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.1156855060446495,0.14414657843175072,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04683302034252659,0.07960314615219585,0.557706094933974,-0.20486524612366203,0.11119920543860884,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.028124994811382368,-0.09565908558726335,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035932842190317976,0.0909257888318243,0.6935896106687951,-0.21644335571356177,0.14457767133292582,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.00842641855771341,-0.06577562669467199,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012548073463019744,0.10173295721851884,0.9020958742191081,-0.21451352887104166,0.18941738194500216,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.027840457961494935,-0.07189644031673317,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032854635004197684,0.13040354107053423,0.8016271490419313,-0.29173839577562743,0.22602912576723208,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06079026978362665,-0.12978679772497753,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03055792641669572,0.26679715062630904,0.9090544954221556,-0.49910138459757647,0.560217237430968,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0726753489694203,-0.06802783812791313,0.9888301126476031,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15102905011796292,0.1545548308122958,0.33095818582950154,-0.457859183085266,0.1558010828493402,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08405745462622269,-0.300119911593503,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03717418511858572,0.09238965124935064,0.6883207470633003,-0.22059083297522306,0.1462424627380516,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02372215440574426,-0.04045146353318124,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08092031432184736,0.14591514970722905,0.580491389351755,-0.3705985117053174,0.20875788306162263,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06665380740399415,-0.18283035532898712,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10966611346388723,0.15327711359620183,0.4760697099489428,-0.41395965704573884,0.1946274301179644,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.010706935760274714,-0.15410218099219564,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09074295274880399,0.11149664654972428,0.4177589344314515,-0.31209178219955347,0.13060587670194546,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10044147343391054,-0.21295096544060255,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13026132639688603,0.18000000499330968,0.4710441084075776,-0.4876065169415131,0.227083864147741,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.03178626623789903,-0.22473921815184372,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07676787108963196,0.13559258223991816,0.572616155411569,-0.3459531810498317,0.19241743887056778,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09129899843571412,-0.2007312419797968,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060931625238843226,0.25050588164920046,0.8083483252925571,-0.43638542769018607,0.5582486781678725,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.013638208754726128,0.050802293207498336,0.974516576191754,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15075623549739792,0.20651087998019482,0.4671767690899915,-0.5607321672136454,0.2592196962188495,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16527966803362823,-0.3684338124818677,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03137784904866527,0.28049759078662584,0.911166508358944,-0.5254802745423935,0.588235972639724,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.022029301891673007,-0.001784205292833696,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2699052875386552,0.2539175437100467,0.2904927138584824,-0.7739953459976139,0.23418477092030338,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1932054560276884,-0.5004716004711136,0.8780447660402404,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041247998972591376,0.36814428521975884,0.9110256940410164,-0.7721068106412906,0.6896108126961079,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.008239477617491683,-0.06247829414835264,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10519182035450696,0.13981417447942826,0.4536894992070284,-0.3827580505446007,0.17237440983558677,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1484185503550664,-0.30370976648736925,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057444234060127816,0.15349209805132932,0.7090532527938054,-0.3621645757472602,0.24727610762700453,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.012323125824442806,-0.08702690307179287,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04059716005651242,0.10592878403176688,0.7023910031203939,-0.2508923848560857,0.1696980647430609,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0421210138432964,-0.013274678632827353,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04308727097990483,0.08637847940097601,0.6190596115535348,-0.21457023389229024,0.12839569193248057,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09664220094539347,-0.16254512358607592,0.9575399837318704,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16584688713033038,0.1340670916412563,0.2191199495553586,-0.43200371534869286,0.10030994108803207,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.06472461940948743,-0.17781786231016716,0.8337844604918982,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1550310232552842,0.2329854005911623,0.507400059321228,-0.6175655235818795,0.3075034770713111,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1827947652081743,-0.39067318387397537,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039631340714899106,0.11936561199466694,0.7406082896344108,-0.1973393602820019,0.27660204171180014,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.046769790963583545,0.07162001894458495,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015983093287210516,0.10828232666659737,0.8829667473120886,-0.23095069096438273,0.1989845043899617,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.049258927457485925,-0.07773309987877115,0.9870713197539774,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09934341462816682,0.13401970790998533,0.46036441544456475,-0.36540617424647354,0.1667193449901399,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.031129034911560743,-0.1617659046510414,0.9366557334939974,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026207396928903802,0.1367375952261246,0.848416058557399,-0.2976658450690009,0.2452510512111933,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0808496314012465,-0.13891902091926567,0.9827413793708789,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06398261783116733,0.12124367702320661,0.59892464892697,-0.30468174931063224,0.17671651364829755,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.014794932748070071,-0.10158029663078874,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03336497942834662,0.09717965031931625,0.7321066071504642,-0.22629097774544127,0.15956101888874802,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06470343336620997,-0.11554256639664165,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027719300161517742,0.12357215758127253,0.8229926119899245,-0.27304105000553464,0.21760244968249917,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05338369457942127,-0.10196565053335896,0.9798720835700006,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0808202750129205,0.24032259020600233,0.7373870088403267,-0.5579209383853141,0.39628038835947316,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15323538423799257,-0.27814042435734887,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054513493799725456,0.1893310331627163,0.7740299151934268,-0.43038311738143953,0.3213561297819886,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09384597256972306,-0.18602282107741336,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006337117323022862,0.13083742237760376,0.9614712068617517,-0.26608224139471637,0.2534080067486706,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.007144781869107783,-0.026521061464965752,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13340307026223058,0.26266834578027426,0.6127171666510027,-0.6548656673126187,0.3880595267881575,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.054049986359139705,-0.2631825798122541,0.9552369178668337,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0268940789658147,0.2154884781263303,0.9009414984037557,-0.4546927964107798,0.4009046384791504,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.030205860926062374,-0.09566405612149083,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04204030794342718,0.15396347471432584,0.7854045759369328,-0.34769645062380417,0.26361583473694983,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.032222255599183326,-0.08250079075160908,0.9722536916492144,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039876251369302305,0.19207517058537096,0.8359798212018066,-0.34144117378450406,0.42119367652310863,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0675063619475292,-0.061368475496056916,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19295336246393802,0.22596490845358042,0.39530374882381225,-0.6415504237292705,0.2556436988013945,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.09003781189101535,-0.17576282137663102,0.920957044807631,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12167784465731533,0.264414536776475,0.6464397541557942,-0.6466070691352296,0.4032513798205989,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.005471745087508851,-0.18618729904853684,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04462022767168624,0.28335567678414497,0.8752080782067178,-0.6071523693574354,0.5179119140140629,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.008780354582267728,-0.10420306529046655,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14123396221443194,0.21396915004699438,0.5108080748501618,-0.5660164320652357,0.28354850763637185,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11840122049295326,-0.3202245913875015,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021649674823581287,0.23837735266485402,0.9278260273674255,-0.4948885534153465,0.45158920376818396,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.03585218956642465,-0.0392093962950814,0.9916764739841218,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3263369139189731,0.43050084190946825,0.45030334113634285,-0.5283153144933493,1.1809891423312955,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15512157486455758,0.3200856866921219,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07608905031050756,0.14285798810264358,0.5955401579529451,-0.3596980145505845,0.20751991392956937,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1132532529050301,-0.21875268370723702,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09032484342930376,0.13413316130666478,0.5023298658977899,-0.35661283651721987,0.17596314965861237,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10992482046050059,-0.22823017005914142,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013204482877444204,0.2034522298764657,0.9948352052777079,-0.40258329524069125,0.4052241918161801,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.08674664817256694,0.0604550996377784,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04856954151644334,0.12380988843434722,0.6957217301492363,-0.29436324677509185,0.1972241637422052,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.036473529665373705,-0.12795796611154792,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02580574196524736,0.20014589911532762,0.8976819347439132,-0.4231455890322004,0.37153410510170565,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02022724044235015,-0.0300789192181241,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0033378863670772904,0.21054246659456033,0.9873843201389592,-0.42131752945522805,0.4146417567210735,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.055808470425374165,0.0273408009074948,0.9990191441902606,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026601817205674956,0.10251485100531685,0.79581690446371,-0.2301195280385752,0.1769158936272253,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10695078936779247,-0.17418714505329255,0.9735235918682278,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021905606515010712,0.07221836017033982,0.7623057554274901,-0.16527717851496587,0.12146596548494444,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08678884888310823,-0.16451406478312416,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0012666857273385124,0.17796237812554638,0.9943358574702461,-0.35456667548796117,0.35203330403328414,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09944685873515605,-0.1273518514087447,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0367977216403718,0.15909227671005208,0.8175807617451938,-0.35263582362956425,0.2790403803488206,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.023794323412364572,-0.0258689318510568,0.9781640470283297,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06870956319987515,0.3511616610737646,0.8452913599359494,-0.7658536032405201,0.6284344768407697,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09618370079523603,-0.21686334318323236,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0485602001070044,0.24139772736259618,0.8410014957202033,-0.5277952805984361,0.43067488038442725,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02207327507298136,-0.057634002537958584,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21289876419533205,0.25809779001775207,0.41150822435057877,-0.7252876608315783,0.29949013244091416,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0454191101285034,-0.2458525750280854,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05530487528553983,0.3087805715442619,0.8582348358944816,-0.6683118148079267,0.557702064236847,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08097080109208636,-0.19389228405000206,0.9839047884462332,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09092455291304066,0.1343011783245469,0.5000386889392028,-0.3575461019543139,0.1756969961282326,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06814583659713261,-0.1911493708095331,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1557938324889136,0.18650170636490493,0.40561775142695056,-0.5260465322060172,0.21445886722818996,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0343030254416068,-0.21800937421988237,0.9237532919369174,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08313656458972772,0.19932122891328807,0.6775474796516946,-0.4788392343105176,0.31256610513106214,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.18835358072313102,-0.31154127546625693,0.9619695749374265,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04337930823587134,0.07752182910011389,0.5770860490683776,-0.1972795972507403,0.1105209807789976,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08092569570017696,-0.13537090070617777,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07420523739368035,0.1752266157225934,0.6729011930120278,-0.27366357731111723,0.4220740520984779,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0975425633481535,-0.0026832162502144997,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07544762192230717,0.11645513216733516,0.5186326677227232,-0.30664028992130454,0.15574504607669018,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05302780414000553,-0.0646698970969171,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11420209050399932,0.2026509899803748,0.5743945409347904,-0.28811099071667035,0.516515171724669,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05466325054455342,0.11571084201743542,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08634500642248437,0.15431954820196228,0.5771231075080967,-0.39270804435151463,0.22001803150654586,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02890620813128299,-0.09032349426074945,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049293178426304096,0.1439909703928819,0.7328548742542238,-0.23656504004242657,0.33515139689503476,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07662600011054915,-0.017607010662954427,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06941291231292551,0.09657445729563076,0.4740589953746689,-0.26113745057243176,0.12231162594658077,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.009366185699864873,-0.10067071559846294,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008464540124862138,0.142287997889366,0.9526877594954868,-0.27401285047231505,0.29094193072203933,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07699417447489518,-0.0810228648583377,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03701165427689048,0.08987822647888967,0.6814152930739319,-0.21544249358773235,0.14141918503395137,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.003582490467539026,-0.062264311319256374,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014022575003154533,0.0951337227744025,0.8831298082974989,-0.20288689360860207,0.174841743602293,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.13690306906261948,-0.17690947875923005,0.9870713197539774,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024905652101027628,0.0681418893345825,0.715553028225149,-0.16018440628351963,0.11037310208146436,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0014065878983552113,-0.039461623226183004,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06721420300995774,0.09130363043052847,0.4634464024890894,-0.11404642092628102,0.2484748269461965,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10607842204564698,-0.03893238008621318,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1639749406296713,0.10680035657172796,0.12802402472944138,-0.37600045568883345,0.04805057442949082,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.09414074060694987,-0.14180278163644505,0.7288842902994255,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050096193986124624,0.2097163550259333,0.8117163318394751,-0.3662434102813988,0.46643579825364806,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05981182442806859,0.11704698578701231,0.9759776192277725,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0324856901492011,0.1152788080019843,0.7787090128341778,-0.2613430594184835,0.19637167912008133,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04433152920322866,-0.09944752099459869,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04111832960872524,0.18395068932068126,0.8236037190874603,-0.32406996096136426,0.40630662017881475,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08711803784318281,-0.04038796499190437,0.9798720835700006,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01103376125799137,0.09163632914485582,0.904414122879829,-0.19295487565071473,0.17088735313473197,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.005971650378444127,-0.020524814236057797,0.988603595072994,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021569601127664303,0.10661200498485583,0.840100233870049,-0.23322119100997596,0.19008198875464738,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.003764284664981196,-0.056024138435409654,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07157917011146103,0.08907251697467629,0.42363099825434236,-0.2484104738205264,0.10525213359760432,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08267787889548074,-0.18235579496889304,0.9288749656602147,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06326877649044471,0.21689954216979784,0.7711549012335284,-0.36733125726283006,0.4938688102437195,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11496202275636126,-0.051933007162788994,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06351947083767202,0.08360832184906547,0.44929918850583095,-0.22950297569024847,0.10246403401490443,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05568053062142412,-0.033693203231762746,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15886397539949304,0.21790754320452574,0.4666290294626495,-0.27021661825340665,0.5879445690523928,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13173987997730077,0.34275408384993405,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04345716322398747,0.17067055768061193,0.799212473258767,-0.29260933145414386,0.3795236579021188,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09177411946315468,0.14832010904621526,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12831019303884708,0.10818587900358727,0.23669450922565186,-0.08471805052292003,0.3413384366006142,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.03747162667052356,0.16784840263767942,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08738790710461895,0.21082629356359764,0.6788470155333423,-0.3277490352407077,0.5025248494499456,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.18125037647415895,0.32562817390897975,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0922036078472984,0.1641821721183017,0.5748750450514732,-0.23108664105254012,0.41549385674713696,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17642235547050292,0.22280772483327488,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17754941458176193,0.09069606725068959,0.05133888689990685,-0.0010397329328935,0.35613856209641737,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.052299980550482184,0.2166445879908191,0.5316325649082267,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05651185542363154,0.18055317011488436,0.7545360332803301,-0.2990144392585736,0.41203815010583666,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15979879573138672,0.2181115299147381,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1204129583132145,0.1276354927883505,0.34634225036096666,-0.13091341713677682,0.3717393337632058,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12822285357446817,0.19029788327950067,0.9075908470661285,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08488367763319196,0.13270155754274057,0.522955701894245,-0.1764182591963219,0.3461856144627058,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0996849502947963,0.14965255870577537,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0004158011017592209,0.21289891803062425,0.9984431886975931,-0.4196339373500275,0.4188023351465091,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17341555886574475,0.21086149326129794,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12346041322684777,0.13714080284130423,0.368819407942903,-0.1465828180987943,0.3935036445524898,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12473967743250411,0.29421480375620856,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012185244218154189,0.20830285458126882,0.9953370516874218,-0.4089495275369667,0.4113865763805975,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17209458114253262,0.18611490198868777,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14632705961592996,0.17879777713414546,0.4138787024911671,-0.20574270000928258,0.4983968192411425,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11701410751361552,0.28437126176208094,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08870003378658024,0.14015539120134196,0.5273731319246251,-0.18727920757396938,0.3646792751471299,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1213231346222374,0.17567186585794586,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22985401050715276,0.23906919468037163,0.3372138635492521,-0.24089587941884233,0.7006039004331479,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.02867777412605974,0.14540975299575645,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10763181062439002,0.11224843488870785,0.3385109422056246,-0.11339599029689222,0.32865961154567225,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.055972869352093016,-0.02790734921247392,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03469831813840367,0.10579579023148446,0.7431939113044741,-0.17362361423222472,0.2430202505090321,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06581373967789837,0.05643647477616591,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11462273887600553,0.13043285102691007,0.3803249002665059,-0.1422118999227877,0.3714573776747988,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14032427838410272,0.3032910536043016,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08384783618275793,0.13973954745818054,0.5490072364558172,-0.19131256945710684,0.3590082418226227,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09965627796817267,0.19317769377955532,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08920323377708217,0.1113582532190715,0.42383284525337583,-0.1300717151150806,0.3084781826692449,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09360006046036633,0.2282101624967622,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22119180865469293,0.22732594305146395,0.3314461878421877,-0.22643450644572702,0.6688181237551128,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0700495856143615,0.27601072814378447,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1046488351742159,0.16496371836437593,0.5263918440777062,-0.22018035231536193,0.42947802266379376,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12554874318031223,0.28531070428387356,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08272303668041485,0.09995112484351903,0.4086333973884717,-0.11409019591098225,0.27953626927181197,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.01155068217690298,0.044066593450057714,0.9253726913029282,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02003586043719618,0.1859198582461611,0.9142640192297391,-0.3861296724042751,0.3460579515298827,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1813910814281881,0.16164721292326611,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08541506057108006,0.1201983466080143,0.477955733412029,-0.15126686957328503,0.3220969907154452,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10343216386097034,0.17730923495633283,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.106315323483189,0.13338229754738687,0.4261335816237537,-0.15632705489791798,0.368957701864296,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14964512438517974,0.2752374478026129,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08454664681922873,0.0983562136609696,0.3908003990904102,-0.10912605457729531,0.2782193482157528,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.024405453325026055,0.09256518251202943,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12059226847653544,0.11240680134763259,0.28434278686239106,-0.10074737100348065,0.34193190795655154,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16023700967727628,0.32748607443115096,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10597069290431221,0.13412272154790075,0.43018518785373216,-0.1581296504697604,0.37007103627838484,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07520306118595084,0.1718679465155452,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06332765042241621,0.1064778148373302,0.5525260239376788,-0.14633725300124956,0.272992553846082,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14705624299771286,0.22544433190436527,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09907879061626655,0.1297432493028674,0.4457639473740036,-0.15639795706602427,0.3545555382985574,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1326792318230554,0.18981440768323352,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12604471567817266,0.17576762520501774,0.47394750512289785,-0.22005838777034997,0.4721478191266953,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10539670612150868,0.2142470591476881,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03872798939055699,0.1627777278899871,0.8121302299200666,-0.28179677578909657,0.35925275457021055,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14293950995984842,0.1853159678151134,0.9761795525598862,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14411660916532204,0.15064860549582468,0.33963381442745766,-0.15252476510073143,0.4407579834313755,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06018009252096886,0.2027207530637895,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09430258300531696,0.1774380675681827,0.5955468122136618,-0.2550897796873294,0.4436949456979633,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09484093919163465,0.18113185107638144,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0416613665680325,0.07913927020514164,0.5990358369586961,-0.1974940859934799,0.11417135285741488,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17425544925006606,0.1798932417373612,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1278612967041619,0.13105919643387878,0.33016628424848216,-0.13020667553092113,0.38592926893924495,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10211972248984628,0.1930901207089904,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05531753244935366,0.07017207908028657,0.4312292918519217,-0.1934930031413762,0.08285793824266888,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20734495426342242,0.2223614047807665,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10442842216491448,0.08943294097601308,0.24400431994147226,-0.07167351006647711,0.2805303543963061,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06729790360266788,0.12578916068711105,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04115899261157281,0.09900495690605755,0.6779516808440669,-0.15379114568611157,0.23610913090925717,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1305253711040649,0.13778033058166145,0.9620942694833536,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09912979320732077,0.10441072276024414,0.3432845221429641,-0.10646481011324668,0.3047243965278882,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06703865833115073,0.13216221676953205,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02515747818841582,0.09990774257648204,0.8013883363273537,-0.17157033060984175,0.2218852869866734,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1107427052521929,0.11008994605797806,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12046510290959872,0.11441874542980554,0.29338617516421117,-0.10483624504769085,0.3457664508668883,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09587549623742246,0.18142489897705943,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08203349551369808,0.11732241906536624,0.4850408477796285,-0.14898546087971276,0.31305245190710895,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14768135184336426,0.17141816176726116,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041680874446291996,0.07990059737078369,0.6023500865632131,-0.11565097028429068,0.1990127191768747,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07543457473811375,0.11965741679780906,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07961052294359387,0.10716108627561469,0.45820724004748037,-0.13139980666428625,0.29062085255147396,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0878764456562469,0.13601400953053924,0.9364698948241243,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1113599759993763,0.12826937995623588,0.3860973478544799,-0.14121458332853576,0.36393453532728837,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10825070924153772,0.17148261702936807,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07004240467344403,0.08057400891832746,0.3854857044718646,-0.08861545118251579,0.22870026052940384,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.05384774926747732,0.0922797090639069,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04361789684535722,0.05532583192042919,0.4311886951183427,-0.06532390689237251,0.15255970058308693,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07930648102511971,0.07216415215257918,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11595180967395044,0.1357997855799275,0.3939744921906835,-0.151450831637466,0.3833544509853669,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1108001950098515,0.20965703499195928,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032214079635908686,0.07274700333535174,0.6582602159532017,-0.11103166082156943,0.17545982009338681,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.061818432997738794,-0.1102088601175458,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043764206428743284,0.08187602411083536,0.5934382449615201,-0.11745744067340586,0.20498585353089244,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.2168736499536879,0.2573883086901889,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21871630320466226,0.18633517818154133,0.2415535573036272,-0.14819531305596315,0.5856279194652877,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06602599012309468,0.28441476778787095,0.8488057272581641,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042718144254699046,0.1277153230920685,0.7382864586564908,-0.208765424625162,0.2942017131345601,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12346688110707989,0.2573647557133608,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14339602361814058,0.12674040138918297,0.25891884182611535,-0.10616783208021488,0.392959879316496,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13512113875777948,0.2779259786904943,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04674103952061811,0.1680203169912633,0.7810891965457836,-0.28410688019867647,0.37758895923991265,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.23187610600787215,0.23949577633975278,0.971527114099096,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17978591161468763,0.13690826165762846,0.19027384903179734,-0.08979942409305611,0.4493712473224314,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08408234533492667,0.2085964607368858,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03431427284271983,0.15434698408138825,0.8242394012127991,-0.26960955918367535,0.338238104869115,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.19849019355855585,0.33598466171704383,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13339904389776922,0.15279142699258952,0.38342234985211443,-0.16746174887212686,0.4342598366676653,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11490382169342467,0.20263550341116007,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1109002768279353,0.15004683853472373,0.4605077843027131,-0.18455616128991176,0.40635671494578235,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11501825865352507,0.2100457649993802,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052637601439660495,0.060940860421899716,0.38851890621640306,-0.06736072529565808,0.17263592817497908,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10612281663743703,0.09498480792136274,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06353413840704261,0.12159274394422497,0.6017544258063352,-0.17589349217527256,0.3029617689893578,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.007420869885002095,0.06115004356977604,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07366588541512925,0.14610891815635452,0.6145569120501456,-0.21403641446197508,0.3613681852922336,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12567811373380933,0.13014171209392064,0.9557595790374268,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09041625257987755,0.16425914792946594,0.5824823750861327,-0.23302556898360333,0.41385807414335846,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11444032350159453,0.24919625712450816,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12335220796645562,0.12248551636225559,0.3148310443415757,-0.11783337607397353,0.36453779200688474,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07507928195262002,0.16290419013035412,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1135019389259263,0.14727991861443468,0.44160875865957927,-0.17650617177503397,0.4035100496268866,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11232958808966867,0.20345410176615142,0.9325592780632456,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12470077406064513,0.1537172032047286,0.41796989327932765,-0.17798295976421724,0.42738450788550747,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08762801973821983,0.1857633904015973,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1466890591741532,0.09662037310861878,0.1301743007155422,-0.04356560774895937,0.33694372609726575,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17221777398276042,0.3002835531899394,0.7333906673033306,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07867812964927966,0.12593087594434638,0.5326662731128211,-0.16929169376667064,0.32664795306523,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11605221466143449,0.13372669528939984,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10471648911991965,0.0938791065786309,0.26568797602430017,-0.08014036434180197,0.28957334258164125,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12329190477084269,0.1859538282115717,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09233542941155867,0.11693256283531296,0.43045082616302566,-0.1379158631361195,0.3225867219592369,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14432629568415517,0.22685147667192657,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02156080647566685,0.11138456862691876,0.8466624768058408,-0.19776595994724894,0.24088757289858265,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16148805360817314,0.16923313700582218,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08367546880026612,0.13288241535339063,0.5294446123863847,-0.1779825941900005,0.3453335317905327,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10557198271044688,0.15440803341685036,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1006586586519333,0.19746716947431026,0.6106581907705486,-0.28817290293136044,0.48949022023522704,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12615889113304363,0.280607242857321,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12041537750089785,0.08034682449472676,0.13516129961320458,-0.037795130705165395,0.2786258857069611,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10313697023091467,0.15918398303875442,0.7471520865805139,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0247608930676513,0.15292855868047214,0.8715008137492848,-0.2763699249853534,0.32589171112065596,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16665767275447657,0.1814960909063799,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1280850192468134,0.11962501763369307,0.28528402762163935,-0.10746797183907555,0.3636380103327024,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09909479225991337,0.1736231038100915,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07775005211747395,0.13186662145872174,0.555961309165633,-0.18190781647408655,0.3374079207090344,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14403926935482766,0.21105549441542593,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08286593462215168,0.12355103979084038,0.5030034258130767,-0.16041776597984647,0.32614963522414986,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09571705775165572,0.12240756241599549,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0945966576417295,0.12299194885925635,0.44251226637575547,-0.14758613995662706,0.33677945524008607,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06670962967599271,0.15949667236851062,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14073440749211802,0.14829094504899393,0.34347691829989724,-0.15126451002699948,0.4327333250112355,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12532416817576922,0.2696500737900365,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005443580550821856,0.08297289732325466,0.9477411538684244,-0.16882507490848842,0.1579379138068447,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08288631905056383,-0.029548625198520678,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08211792693954036,0.12212652837538311,0.5019236475168714,-0.1583607757499439,0.3225966296290246,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09992285606667753,0.16298058383223105,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00979366078913784,0.08507173116103985,0.9084366326896773,-0.1773079577834272,0.1577206362051515,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0808468488480756,0.007795027910338745,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1196624131137735,0.11742055382311331,0.3091027263151839,-0.11154977991336222,0.3508746061409092,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08682607934395642,0.20534307067268584,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07463526623764481,0.09413785278769336,0.4285972581860521,-0.11073108301920746,0.2600016154944971,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10120107100102307,0.19408310698547931,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13627239185498155,0.2294895963440744,0.5531558925574734,-0.3156143615285729,0.588159145238536,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0715090296835809,0.17151382412474978,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09464162108340686,0.12071124966644807,0.4337316129571406,-0.14305026376726498,0.3323335059340787,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11554288041841311,0.28204953045896397,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13816859500969836,0.15484765855313362,0.3730608814349148,-0.16674111247747292,0.44307830249686964,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.138537090640524,0.2705176819974021,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10441451194582174,0.09437224909138513,0.26956731706042714,-0.08141338583596483,0.2902424097276083,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.04664956689878581,0.10788493777103264,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17174842431156037,0.17788726728183635,0.3351930449625261,-0.17852845516728236,0.5220253037904031,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1067960448758483,0.2771722260860844,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11425718248475686,0.11626310331065831,0.32664221227478474,-0.11467588084496447,0.3431902458144782,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11410482956297137,0.1861655521176797,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06965062134365449,0.14415962136138646,0.6293947605837552,-0.21421332849888705,0.353514571186196,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09819389775798518,0.2056211075039488,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0869592946123038,0.10426890995447892,0.40504888595317856,-0.11835606586062981,0.2922746550852374,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12793573500094593,0.2102865531737043,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08129209057191679,0.1571211378668082,0.6053257619653098,-0.22809431303702887,0.3906784941808624,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14597387099938985,0.26766613719864996,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06540649335051396,0.05249133264131764,0.2138656480842118,-0.03795391281141748,0.1687668995124454,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11691951053845315,0.21162907871749465,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1097977952509101,0.08627107003053196,0.20425458499298393,-0.060078113583634185,0.2796737040854544,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.056779435887628224,0.18452219321060803,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11084599723971396,0.16246204876592732,0.495661571447493,-0.20905716584226347,0.43074916032169136,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14666356231028246,0.2562260036423679,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11576584560366125,0.13351255364712633,0.3866955268737753,-0.14713301937621692,0.37866471058353945,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11142629611001677,0.25357381631695297,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05848083763511139,0.08755681592076991,0.504775652877655,-0.11392682664835863,0.2308885019185814,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10381565774714484,0.13936356132339758,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09640375304331872,0.09710605695815737,0.3217426770193263,-0.09480727138547251,0.28761477747210995,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13207140902421777,0.17563741588962067,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06634267356816953,0.06437315975400044,0.3036847288856787,-0.06041417567332011,0.19309952280965917,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.043185948081305714,0.0912700180381645,0.8913059585247131,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005975338501746194,0.10338987145783227,0.9539567524153525,-0.19760911190521102,0.20955978890870341,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1000538840406286,0.036803985330298425,0.9945506567734527,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1590091626596146,0.08217035095019537,0.05405636963687532,-0.0027920418690621784,0.32081036718829137,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.015274971543641817,0.10683717789127636,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007990860662763123,0.1057784385743878,0.939840255402868,-0.2162786259769491,0.20029690465142289,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11257253187810468,0.06484492176519124,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18503902869594005,0.07770831104401618,0.017973971173836128,0.03202400340498382,0.33805405398689625,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.008518265309616637,0.1950687119404399,0.3048662033716051,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01527093900065614,0.08924046389376891,0.8642610222457582,-0.19099386562490184,0.16045198762358953,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10346507389593826,0.005003276392222589,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19550366004036146,0.09023088440037899,0.031162378229717735,0.017830501621967254,0.37317681845875567,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.007303687828550615,0.17656849467445873,0.42195400245230363,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03203071821623947,0.08567718806522266,0.708816809891782,-0.13667578077371084,0.20073721720618976,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06543669523053118,0.01425081300485951,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021528756505173944,0.0800892642915179,0.7882886286181775,-0.17923210427397554,0.13617459126362766,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0739538436346347,-0.03966464174273175,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07863745033764545,0.08455304905200853,0.35321140189409683,-0.08785551245229554,0.24513041312758643,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09958040385856018,0.154192062167134,0.9092831415853414,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10215212693241219,0.13982421827951996,0.465693858397768,-0.17317500357503227,0.37747925743985666,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1347608746697325,0.19358835227252308,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18609638803997194,0.1632170577708226,0.2552576429997294,-0.13529345929014866,0.5074862353700925,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14585711152480949,0.34440048044682625,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005289609101852634,0.18797055028040838,0.9775714962338512,-0.36484220973049675,0.37542142793420197,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16809832960772841,0.18828049778739825,0.9983210449785855,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0512349195773641,0.07799963993055734,0.511849075353539,-0.10235375988704123,0.20482359904176942,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08483650027227821,0.10305421791466268,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10125488785537978,0.11978337486870241,0.39870828453935003,-0.1346099236264799,0.33711969933723945,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11269500885839291,0.22311150056621956,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05477223158312674,0.1257230703009951,0.6634451350165174,-0.1927884028368745,0.302332866003128,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17147221396494977,0.17518820815183328,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12309573531117823,0.1420312586539485,0.3869130867070739,-0.1565772667533003,0.40276873737565677,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.134676106548647,0.2624754967997639,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07322912159535248,0.13182602324310358,0.5790297457242648,-0.18634880526402875,0.33280704845473374,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11044884585628456,0.13988248039998472,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15681654958972965,0.14902639660643707,0.2936472553265759,-0.13663054171093728,0.4502636408903966,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12591276862662093,0.24187856093495885,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12320017409075801,0.09192586016560039,0.18134182640163318,-0.05781055216431205,0.3042109003458281,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.057478456319127076,0.1658049935023631,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059750359824582856,0.18589947020172118,0.748155270463597,-0.3063033061517558,0.4258040258009216,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.18653322202292935,0.24453653824260374,0.9637098944799569,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11097509132084384,0.13638351988141145,0.4165592914988405,-0.15757697812386678,0.3795271607655544,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1390122259902975,0.3071762234119252,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007956147225876781,0.17605267664230664,0.9639889422823483,-0.35462054395564546,0.3387082495038919,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13206869477372712,0.08542376835928268,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11930509077549711,0.15893147202691965,0.45352749646357715,-0.19364603227687627,0.4322562138278705,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10072770778852977,0.2552684647404629,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02495938783349579,0.12730950295886312,0.8447213757815822,-0.2756438584301522,0.22572508276316064,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15695469582437394,0.1716717342678431,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.115354362231614,0.11958712516788633,0.3356354842210618,-0.12012401499977399,0.350832739463002,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1402046911554728,0.21245325497857648,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11930648085408063,0.07284868304284779,0.10268302031359378,-0.024139476578970087,0.26275243828713135,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.016442413805398844,0.07619712007289578,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03647667079133824,0.12827306400229643,0.7763543609334976,-0.21610514277223478,0.28905848435491127,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20993531445540622,0.0535182482246383,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10963279945596628,0.12493096068163145,0.3809966176372698,-0.13636809609168338,0.35563369500361597,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09788304831925257,0.17524246855458558,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0163856631592018,0.15225115809219,0.914377764472605,-0.2834112889693538,0.31618261528775743,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20484034349194688,0.2727438692917679,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09297725563511283,0.054645895918267476,0.09004941547263708,-0.014625689708074319,0.20058020097829998,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.06284583668770076,-0.019339386695992333,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07568048517433014,0.09667079704852083,0.4344143019136436,-0.11467347126280895,0.2660344416114692,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08186633406662092,0.11421027192637714,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09492242673764964,0.09562666686068202,0.3218069662782241,-0.0933755384554035,0.2832203919307028,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09800330660195133,0.22491793704906307,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07259805897803634,0.11841243315100416,0.5403474653020612,-0.1605672384005352,0.3057633563566079,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07081843750474659,0.08995213890288403,0.9481163084809376,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12637068949835298,0.0825590160460058,0.12706183781265173,-0.036195833419903234,0.2889372124166092,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1042046183288478,0.2670481985568486,0.7266692136576581,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06443536962172855,0.09534702132466619,0.4997669561090965,-0.12331194702175402,0.2521826862652111,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12664413698741628,0.11369031810639577,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11073699967050968,0.10426123297168347,0.28916707067412684,-0.09456324409610484,0.3160372434371242,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1247743590325682,0.19130095370063543,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14849080867524286,0.20658198086779636,0.47290812602711574,-0.2582886799335987,0.5552702972840844,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13873820118664432,0.31995946370692474,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12673046439203847,0.1515463296499563,0.403779792594978,-0.17167861376956026,0.4251395425536372,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09558089621961957,0.21513953716700612,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05953748061760967,0.08685180126959759,0.4936327180168416,-0.1114819430358649,0.23055690427108422,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06732182263297476,0.10330298892171064,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11898643962402175,0.19348491384214547,0.5391136500634875,-0.26200368340419133,0.4999765626522349,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11600925633513692,0.26530067630628473,0.9471659478826966,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12811481715673304,0.13754058565480728,0.35247171254264453,-0.1427156243977404,0.39894525871120645,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12602524635315107,0.23953651499696876,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13417810817191547,0.11804488139578448,0.25671868125781383,-0.09826344498464074,0.3666196613284717,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0815189392440423,0.19444768368053073,0.8647791852375212,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08137574106211107,0.11257834379856045,0.4704275341409411,-0.14030168175297622,0.3030531638771984,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.18707179670444132,0.3046925134341706,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10662827453466583,0.16839043793830352,0.5271441169400071,-0.22494844838870293,0.4382049974580346,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0012730582497861337,0.07344324916847947,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10836471039022072,0.1863424825810258,0.5613817095740677,-0.2585612889248918,0.4752907097053332,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08449208643167802,0.16466493702162066,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04651004749541631,0.15261116081016993,0.7607904733788551,-0.2539957840857542,0.3470158790765868,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07678903888303332,0.17928729380760905,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09364996361984827,0.13931381203651008,0.5020363104408551,-0.18067212864736754,0.3679720558870641,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1265820242148317,0.23626497812694539,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15691955230398344,0.1395156025472302,0.26173017668527954,-0.117799884593253,0.4316389892012199,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.00989193429552054,0.15805077247995597,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15837856443208834,0.17049488240477423,0.3537813824326992,-0.17734200898724642,0.4940991378514231,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.3889815735281196,0.6245440716297258,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06158058000725184,0.12787387451099622,0.6305129740772488,-0.19021519163510905,0.31337635164961275,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15995075339040069,0.24347512918050165,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06888836558561703,0.11857336432499882,0.5617574728055106,-0.1645938205186012,0.3023705516898353,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1587335462177709,0.23270868031843803,0.9512011132956789,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11971463537740408,0.13344902624939495,0.37050221184111365,-0.14305913813876914,0.38248840889357727,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.046858755139041953,0.12001519391445353,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0797265325165157,0.10205325207663585,0.435378317558922,-0.1212259877188759,0.2806790527519073,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1454477704649208,0.1997997882160708,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13583628080969226,0.14398787578719507,0.3463554528204873,-0.14768948572883148,0.419362047348216,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.05498247121911049,0.12435935575778072,0.9075908470661285,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15804547034903638,0.147325581791598,0.2843682208072474,-0.13205255547315914,0.4481434961712319,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0553848748988315,0.16037639328131834,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07354673684152542,0.12311491080215685,0.5507697066512693,-0.16887818446985442,0.31597165815290523,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09936535756144915,0.1855471721122692,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014676176939596199,0.09729517039960107,0.8802170398254127,-0.1769072297689872,0.2062595836481796,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1094070916187813,0.03377424781722521,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13469397318489695,0.13257564823502402,0.31058062213518434,-0.12636003629108455,0.39574798266087846,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15049420233169,0.2576202801039341,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11747520848085384,0.1150117605253479,0.30800173151002247,-0.1089938423723452,0.34394425933405287,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.03902848233563471,0.12333930749576857,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17847415598824953,0.2000002508943237,0.3730168175691969,-0.21534528285476048,0.5722935948312595,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15808725599209947,0.3696533515339028,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14628918649020012,0.14793337111410818,0.3236349551366319,-0.14500563408027906,0.4375840070606793,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09582414756901643,0.20689134186481983,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1271219133111678,0.16315330100062592,0.4365935644524781,-0.1941423908991366,0.4483862175214722,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11511470106468961,0.19716994932428333,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10116620812448364,0.1912187475886091,0.5972134165935759,-0.2753616188900899,0.47769403513905717,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14642366026043604,0.2663013779182892,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054502806972511135,0.09803274285128795,0.5787108361996667,-0.13853294975928732,0.2475385637043096,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15226232699074585,0.20153247993778622,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024908872174746945,0.11445021115799793,0.8278801536338861,-0.20045443478191438,0.25027217913140826,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.008614504409921099,0.00766027006432007,0.9814385692272681,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16421444198931345,0.1954055183979723,0.40146582839704215,-0.22055753333674855,0.5489864173153755,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14408015798005452,0.2670990023451021,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007322683818265168,0.08906055170807879,0.9345336703698208,-0.16804597867034732,0.18269134630687767,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10625682048476011,0.04431398573279276,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061262473642323186,0.10235092094404136,0.5499899515038096,-0.14027618478938805,0.26280113207403444,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10682088199852431,0.1310258518816888,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020058878986181142,0.08307456570791512,0.8093910533518979,-0.14352281005132214,0.18364056802368442,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12226653843972497,-0.011746067112475056,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06223161634651723,0.10442209875295196,0.5517169953979504,-0.1433853873812719,0.2678486200743064,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09262227378384388,0.1406510725865061,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027735895052377026,0.09475969043253887,0.7699861758389686,-0.21432670153490507,0.158854911430151,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11080687512934285,-0.0986161059351305,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0703599239883295,0.1033541598014221,0.4966235062729619,-0.13315420678440365,0.2738740547610627,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10347988780556848,0.13518383702327616,0.9433351023677367,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03628430477289535,0.08698937329933427,0.6769394170463074,-0.13500601123850942,0.2075746207843001,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12585862367554593,0.034631453329310884,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07775497209348133,0.11351374625299844,0.49396258852315644,-0.1457643467594954,0.301274290946458,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08674246728377547,0.10021197530066929,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0617085380783774,0.08965932578727415,0.4919030573774401,-0.11483916729047153,0.23825624344722632,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08870682773358242,0.08674520274502234,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04902142415479961,0.10251518114277719,0.6329174129596875,-0.15284067816761238,0.25088352647721157,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11647120352022197,0.11135904263889101,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017616240709064805,0.0852601245052896,0.8364696216270031,-0.15026902062543127,0.1855015020435609,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08813718510165411,0.06443058784485742,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06781421099306013,0.08384962657133409,0.4193898959505834,-0.09729364630141259,0.23292206828753287,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09615806282614041,0.15070774082758281,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03788880911797234,0.10660989979094809,0.7225794488647488,-0.24781380032693243,0.17203618209098773,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15044269750791087,-0.11118065138202379,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08121270616507,0.0914926263334846,0.3755505441861625,-0.09894494163690452,0.2613703539670445,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.05491585477199745,0.09858268181934647,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10328837994066596,0.09457447778500881,0.2757795382492037,-0.08293772529478484,0.2895144851761168,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0725021702846907,0.12984667572444478,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07651813093803705,0.10205369389766258,0.4540606729940495,-0.12443525928480725,0.27747152116088136,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09058089491791965,0.11121334931645221,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05516256465776522,0.10030005176534207,0.5828065488831413,-0.1423377380944697,0.25266286741000016,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0876019769138064,0.08981878255533307,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0829666777385553,0.11560132307386035,0.473586242564372,-0.14466327761841213,0.31059663309552277,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07443269617697741,0.11812266315914305,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0594248959958487,0.08186301726405615,0.46854651392406854,-0.10177113939293107,0.22062093138462846,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06802752166917457,0.08059268665084597,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09491875308341534,0.11818555625787122,0.42262847852503715,-0.13779980220188115,0.32763730836871185,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20246194050596827,0.37078289936503384,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018169647676626266,0.07994511661537028,0.820386655463657,-0.1392498596635902,0.17558915501684272,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.027175905065745715,-0.0635028097255468,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016852288076850522,0.08138494687495933,0.836240707813955,-0.1776789122371724,0.14397433608347135,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0946211729370798,0.027539507904669844,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030067488631169897,0.07668599796815234,0.6955588718280852,-0.18160841416045756,0.12147343689811776,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17165141269633613,0.07897866935649923,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05562655285525813,0.051708275939666815,0.28377775354608775,-0.15780844004508332,0.04655533433456705,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.16410328756807757,0.06771882491791684,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04441137130374639,0.08339142472998759,0.5951332683847903,-0.12038029887881385,0.20920304148630664,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.02104492532534092,0.006069473997184726,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025688816386483928,0.06682515795593222,0.7012201989424041,-0.15774351416179933,0.10636588138883146,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07031177566740934,-0.010996387474392234,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006882621666582659,0.05756539624472533,0.9049924344218838,-0.12063889603897496,0.10687365270580965,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.18933954995161253,0.1472476353207281,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033516836045684964,0.07966461823684559,0.6745667405533291,-0.1239102079964703,0.19094388008784025,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07503628081688919,0.044679788203546,0.9604862397331528,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05792550626102866,0.048101050609979726,0.23041681365558903,-0.15297907433736335,0.03712806181530605,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1366602256941059,0.05243886442991818,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049712636184788835,0.049702813517170874,0.3188473716072354,-0.14793148397144348,0.04850621160186582,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06782695485275714,-0.01887320127564012,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029109724324407334,0.07231909999237654,0.6878837802562583,-0.11380167588767875,0.17202112453649343,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03253564760523578,0.007812376460022516,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05690538815096246,0.04933496123205056,0.2505852912302109,-0.15439731476266746,0.040586538460742554,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0748152164050753,-0.025499884974479883,0.8577585765822857,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05779823859619937,0.08462450827674801,0.49567683756697933,-0.10943015571960638,0.22502663291200511,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.015122427943694007,-0.019228638038120128,0.9425014779477888,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04890452735337692,0.057133399165478986,0.3933975752136757,-0.16180712258029956,0.06399806787354573,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07825725479587634,-0.014986000856513026,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06377053650104443,0.049979499046509696,0.20397771752441643,-0.16253614878588007,0.03499507578379123,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06625209325803352,-0.04704596987857328,0.8179445630780711,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051307340331092285,0.14704524416267045,0.7276436720537289,-0.23927207423615943,0.341886754898344,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09019905686583247,0.13829516214444454,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0019479453523943112,0.12485617504893945,0.9875733099220445,-0.24478315062709394,0.24867904133188257,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.39405716354152637,0.3882477641675385,0.9990191441902606,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030891557868369755,0.03944802949770389,0.43482257360376586,-0.10884569628711138,0.04706258055037188,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03607435705723602,-0.028382762982477862,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013534527989203297,0.05391649835141516,0.8021409710549048,-0.12008013315776345,0.09301107717935686,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08926223711478007,0.031088718950016324,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04134890810151193,0.043964718839773945,0.34849261311160884,-0.12822857792573678,0.04553076172271292,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04416581913506474,-0.03470942642346985,0.9086977961712401,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03426474470009806,0.05001586556158655,0.4943665644351315,-0.13310222167339103,0.06457273227319492,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08093883320339251,0.015379087230815852,0.9421219642690486,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09508025527318037,0.07368057238658993,0.19891081369498056,-0.24068209170789157,0.050521581161530826,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0849447659706385,-0.08382034972203146,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05254438710363053,0.08716408452304313,0.5475500210820652,-0.11970252095669977,0.22479129516396085,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15666251928494507,0.16071541979848028,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019040672266258676,0.052255147464321604,0.7160951842889047,-0.12230324457706535,0.08422190004454799,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17367033594872586,0.09753640569631303,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04929162257853921,0.10184178898931594,0.6290999045129438,-0.15196022743205534,0.2505434725891338,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10971035734955628,0.08120032252345276,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04156976680828908,0.05227755147753675,0.42778549584078884,-0.14487661219355719,0.061737078576979035,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1349174415602899,0.037206575088375764,0.9299900056018157,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04191990153547006,0.04804644486884559,0.38435601063924685,-0.13686556197846972,0.053025758907529606,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04622930251306358,-0.0208765928669174,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07434131926156767,0.05279532754718006,0.16119733709514453,-0.17867135358470748,0.02998871506157212,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.16785882035606653,0.03839896611940553,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044400463792376554,0.03558375741912077,0.21408469294903612,-0.11471832723522668,0.02591739965047357,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.02632765548742455,-0.0388007086744878,0.8289622204693651,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06196035373782472,0.06286376632537231,0.32592375932825224,-0.1861868564060186,0.06226614893036916,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10083084097546881,-0.0024119868800143336,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014727889624026887,0.0447658848026904,0.7426222404139196,-0.07373498228062655,0.10319076152868034,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.015789115240817345,-0.0034362240326256434,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06021337048588186,0.05474111143119811,0.2731328100242959,-0.16838851210992065,0.047961771138156924,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.029713049287949784,-0.07877037138813794,0.8700354117066056,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003938321058581211,0.0697453723553479,0.9955022029171438,-0.13743156703028706,0.13821923124200328,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15004378520283498,0.08039682386994712,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06801479002345434,0.09274888825373502,0.46452210615082623,-0.1152683743114562,0.2512979543583649,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10488594312526411,0.10403423768161034,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08753957234409307,0.05583913886421403,0.11908444811201103,-0.19788455067710817,0.02280540598892203,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08806571654704398,-0.0486098276802561,0.7227005727164707,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0232599386125797,0.07047306423093551,0.7418256413051549,-0.16252334603248594,0.11600346880732655,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07372930185452878,-0.010261763296170711,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02222625035842723,0.0472984292919578,0.639107274340809,-0.11569374039437325,0.07124123967751878,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12178042666317482,0.08839463162780922,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01324932053554901,0.0710419127246081,0.8523080328647052,-0.15363684225925406,0.12713820118815605,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10350882021588795,0.0324857993018812,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06735926980950259,0.041866562382841255,0.1097684364000636,-0.15009272546408362,0.015374185845078436,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07986204929171575,-9.149875936715485e-05,0.6987504796661628,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031625825901685965,0.05785607229035767,0.5854565934638938,-0.145956511746204,0.08270485994283208,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0578610250826954,-0.0036312728967176355,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029530482043895877,0.04577105885530093,0.5198107190167529,-0.11997970100389946,0.0609187369161077,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05519633805526154,-0.01724123671388078,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022838362869055204,0.05595401929260043,0.6837438705668178,-0.13341035900067946,0.08773363326256906,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0934666015961852,0.029784949014766457,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0133782752842641,0.05936338453714215,0.822008240627844,-0.13068759476453679,0.10393104419600857,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.024674860790649608,-0.03443944353063649,0.9793038292216457,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028126820258374104,0.047474459210821635,0.5544452603953074,-0.1219421669765341,0.0656885264597859,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07088103933890891,0.00974501519747055,0.9491210479105492,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04213031400085838,0.04545163514213654,0.3554739322482714,-0.1319483125762875,0.04768768457457074,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.010307337798854965,-0.06920600696120212,0.9108386596575023,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011840496832818764,0.045028750211840905,0.7929516221265156,-0.10082282298528479,0.07714182931964726,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.004600137372198385,-0.03785481661318582,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004105154717012841,0.051598728987805445,0.9366953026791998,-0.09786025427713341,0.10607056371115908,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05397336612960111,0.0378746657355769,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04687374162883523,0.050908700291916166,0.35868389527942723,-0.14747556939580286,0.0537280861381324,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.051269200945235065,-0.03045587369644221,0.9133814160475374,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004879485773077781,0.045277440597349165,0.9143252209450451,-0.09435325459028956,0.084594283044134,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.024534203714767635,0.0037890265069781687,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0021345017212297023,0.043505294379998234,0.9609352118437352,-0.0838372890939208,0.08810629253638019,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.01032441082756291,-0.014892040180496627,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07686791043049539,0.044538332075877186,0.08645562986807295,-0.16488111027321245,0.01114528941222169,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08454979913058583,-0.03411871060929592,0.65578639613287,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05596415436333787,0.08468034733207351,0.5097121138102398,-0.22330289349239388,0.11137458476571813,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.33396253243786145,0.31390526981991845,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034567101621423985,0.0660861546729231,0.6017138966255915,-0.16516143838633834,0.09602723514349037,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.011249704144149626,-0.0866032992785913,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02347180367002171,0.09735479349658267,0.8098147773617872,-0.16891319361868573,0.21585680095872917,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12004222805833256,0.06745241826701606,0.9747331744048557,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004458025710228096,0.060607256575554526,0.941463024137027,-0.11530933728431556,0.12422538870477173,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0917519262188662,0.04842081927934111,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009870837458394273,0.05309016343116242,0.8527574401738449,-0.09504182868700449,0.11478350360379304,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.013939130032059011,-0.03679086391860822,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06025099692041568,0.0734465541964693,0.41334273653838016,-0.20539038474571716,0.08488839090488579,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.013056760739901866,-0.10368508184694006,0.9263451842579509,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0745855430039163,0.06874262957028801,0.27968721325663565,-0.21042939956720613,0.06125831355937354,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03791355407401084,-0.09053715148384946,0.8754562692551948,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06058296322702243,0.07636081079089105,0.4288279165386766,-0.09031535260664779,0.21148127906069264,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03955090400933321,0.06852564700121073,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0025866923087185523,0.05882547813163012,0.9649857454563633,-0.11365965822416847,0.11883304284160558,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03493479785906646,-0.021197510628148786,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059321059470422155,0.05205736374625543,0.2563220422448488,-0.16219278692708974,0.043550667986245434,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03346542626288191,-0.0577175117316036,0.8646722506638599,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020635610028560382,0.049031547435286524,0.6744649517665922,-0.11752795381161038,0.0762567337544896,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08165845739763711,0.022061653833398864,0.9604862397331528,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031530299212971874,0.05181405879272318,0.5437702428555833,-0.13392122627815928,0.07086062785221553,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09236012750569714,0.0032455671477515102,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007923722358289847,0.06460560114877405,0.9025525420875777,-0.13559230400114952,0.11974485928456984,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.105730322311066,0.04156979247758174,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005690088281728883,0.0714658043021364,0.9366472562734475,-0.13553509512317885,0.1469152716866366,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1597403010480562,0.12146876202458803,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0026789818058070188,0.07225975332834952,0.9704757007749787,-0.145473105740189,0.14011514212857495,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15647983217336073,0.10404026642138639,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04392163816604074,0.050436516749108234,0.385257242889817,-0.1435903734129563,0.05574709708087482,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15223821976901086,0.08292291411926297,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01279824658327345,0.06624981034236206,0.8470815800233653,-0.11811949383122497,0.14371598699777186,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0973918548961677,0.0658350825729151,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04633526717945773,0.05154959814181552,0.3701935309467841,-0.14820358760371352,0.05553305324479805,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09923908130485246,0.017615705869445775,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00940863068022095,0.049265524868469496,0.8488045748070152,-0.10676334253197939,0.08794608117153749,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15629878336175132,0.09969278751738225,0.9827611894425448,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0384716025137957,0.04841338017593351,0.42809063749924847,-0.13414237207082905,0.05719916704323765,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15844757139883547,0.09688178170387582,0.9299900056018157,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018514008094115582,0.04493192446675298,0.68090207586655,-0.07027697852552228,0.10730499471375346,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.04434560690268048,-0.03587417784269807,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008662650083247729,0.05525563563731629,0.875636581233471,-0.11785455456450006,0.10052925439800459,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.022533087046379935,-0.05254313790577941,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03925469330968862,0.0393211245795182,0.31975821159238027,-0.11695805206505464,0.038448665445677384,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08703354989015126,0.02301300867845483,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03361371810831977,0.08830214299932446,0.7039961298883479,-0.2081095691226656,0.14088213290602603,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0927933521621622,-0.025376917913850446,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017159844742379665,0.05072293356220074,0.7356124553499088,-0.11739457469619352,0.08307488521143419,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19502683837029278,0.14518890810365878,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011111727358429021,0.07132783305286308,0.8764156486123009,-0.12984080795731917,0.15206426267417722,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.02801643932326062,-0.08322066808519862,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028268139454241746,0.04579222943335423,0.5379768728348696,-0.11875919406973903,0.06222291516125555,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.037092487084101795,-0.020651657796372177,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017400088220283563,0.05030942450723094,0.7299380202894359,-0.0820174971886958,0.11681767362926293,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.07340530038487571,-0.0818796820603882,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020010498752371562,0.04601921089045266,0.664319744815963,-0.11095009653087193,0.07092909902612879,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06597178837052022,0.0031277676675909305,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023188723783563084,0.03915002132081666,0.5545506954156119,-0.10055396154068014,0.05417651397355397,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03520190289907768,-0.03319229267404436,0.9491210479105492,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035212908697011915,0.05302263416175503,0.5076526426909637,-0.13999212873415814,0.0695663113401343,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.004699791213954131,-0.06793692481571924,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003722616262561568,0.041690047388654054,0.9928875941113179,-0.08201237877785328,0.08275690203036559,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.022888334351820343,0.0024092377559345596,0.999521629637202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03103505644189559,0.04988595587629732,0.5348201332371082,-0.1296158159639516,0.06754570308016042,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.01906726887519048,-0.026285699611268948,0.9468590670943479,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006765804719112398,0.04540325703838073,0.881743987650535,-0.09648820223551177,0.08295659279728698,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.018885949505177343,-0.0026694083675296437,0.9867875051416815,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004232547452772118,0.04704040135387589,0.9284272583535804,-0.09719014267629636,0.08872504777075213,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07679476465810649,0.03626870806661778,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02040803354103391,0.05813135935153015,0.7260369220586389,-0.13528272033933286,0.09446665325726505,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.019292783802222144,-0.02493962950624514,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08162475293709397,0.06691101359917623,0.22444309772532325,-0.21384911198022666,0.05059960610603871,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.015332568958398041,-0.11079814528121487,0.8368385672821118,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004362832886104746,0.06147223957085082,0.943515528187298,-0.11711384246202833,0.1258395082342378,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11637159660305368,0.07526014344502686,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03843381252792969,0.060849522095341425,0.528609187086131,-0.15867992186554875,0.08181229680968935,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04297542792011623,-0.03852709331454593,0.9450734236122966,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0314100492015625,0.0495638629531382,0.527235984842803,-0.12935431365313332,0.06653421525000831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09080397502033047,0.028177719196015187,0.9448126253726593,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003821291846691357,0.059504182534633236,0.948882602484284,-0.12140884541686049,0.11376626172347777,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.036699696030943633,-0.01570708380380706,0.993730344541434,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013338038271234847,0.05098584593085039,0.7939914254797045,-0.11409231527058382,0.08741623872811412,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.006669542354783039,-0.037790176527356376,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056503998471915215,0.054759755557826806,0.3038243954433384,-0.16471598317395855,0.05170798623012812,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.060358926014279314,-0.044471743427715996,0.8913059585247131,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053082234871436526,0.04630536834120529,0.2534997138892898,-0.14458731482508136,0.03842284508220831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0554274391210518,-0.03108527568778976,0.86289911185814,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021435508444057685,0.061292953707389054,0.7270443185887255,-0.14255789296461885,0.09968687607650348,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03452632074544087,-0.03740038480692378,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03804747773367378,0.067009239957748,0.5710348683029446,-0.1704659440934449,0.09437098862609733,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10806206042586282,0.05920034461576534,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050454004117137005,0.05133889166612021,0.3273275384672383,-0.1519059427352234,0.05099793450094939,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1459118386125224,0.042746470070514644,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03489427732917125,0.054065036612420264,0.5196589124099056,-0.1417334122964643,0.07194485763812182,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03500134706201524,-0.04753940840142421,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03590271194177031,0.05429735341724278,0.5094967336552145,-0.14320093337271522,0.07139550948917459,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0511923177177003,-0.013516179217189022,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044809521713930045,0.06098978104626435,0.46368144763036934,-0.1653327999193971,0.07571375649153701,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11690809671250518,0.04926014898095562,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05269651862887173,0.048237739678502416,0.2764177103005444,-0.14802020104814384,0.042627163790400366,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.029442804045896633,-0.10063570900170682,0.8724468327497898,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013036052397436012,0.03917895832488075,0.7398082124382747,-0.0904584732191816,0.06438636842430959,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.009264186080077147,-0.038897966202326724,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08060393925026671,0.06895333779659626,0.24429765544472054,-0.21686418107915156,0.055656302578618144,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12679977875474605,-0.0009598101368781531,0.8528284808184983,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006898182547989134,0.09421953869973036,0.9417347379335872,-0.19308753230945888,0.17929116721348062,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.23652555437317893,0.16227955837214658,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06320587916293621,0.059767344447369024,0.29199192699509663,-0.18131347290832223,0.05490171458244979,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10848560124265805,0.011644514402082043,0.8799526010712531,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003956815329968257,0.08025136415431357,0.9607424946887912,-0.16254334117766195,0.15462971051772545,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.2344485900629592,0.16420452601776153,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0704229851511152,0.06717478583033129,0.2961843147313728,-0.20316859043342134,0.06232262013119094,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1139007847012737,0.009406102386131064,0.8833721946393759,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002411733857152036,0.0916424699073012,0.9790401297508837,-0.18350848001033926,0.17868501229603517,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.28545092956540735,0.21088452781902883,0.9984157213799838,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016378599293943894,0.04177232418252626,0.6955541883420383,-0.06616863013323797,0.09892582872112575,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05127045225861484,0.0425534867980457,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06998173665640493,0.04041315568145604,0.08541828382222542,-0.14984308263602475,0.009879609323214897,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09468435837825843,-0.016916842772516025,0.6528607274170573,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05940155131118607,0.04330262059586063,0.17220868738609627,-0.14497283390263854,0.026169731280266402,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.054071828677453825,-0.03616164956092936,0.7850787711519817,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02727300715878686,0.04866226767136232,0.5760166033936311,-0.1234356088939137,0.06888959457633997,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.033660436108538666,-0.01760655073905406,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022052974886037705,0.05554925881034565,0.6919404398219006,-0.13182511472415653,0.08771916495208114,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0503241927262717,-0.012298245116420078,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04437637252413154,0.06725635450642375,0.510401645951281,-0.17728316750203746,0.08853042245377438,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07796000986104197,0.018444897230327332,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05615373469554495,0.03917839573873622,0.15388605191760166,-0.13357504377815577,0.02126757438706585,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11597589403621188,0.032160112452809045,0.7711789647234355,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026362645520944087,0.04767587451225529,0.5811280118979808,-0.12057601354682303,0.06785072250493486,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03858548203508383,-0.02847994251264755,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03829975260407582,0.04271655396113726,0.3713873563179251,-0.122712895735901,0.04611339052774937,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.122320456886913,0.045825355025904325,0.915561182973695,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030658581657510675,0.05428956455075859,0.5731169243210656,-0.1379414113341965,0.07662424801917514,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03804215492889676,-0.03938097647429427,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05136179296106954,0.053729165386233305,0.3406620113657931,-0.15753720524334042,0.05481361932120133,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12322859192940193,0.024848726296355136,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026710530842513687,0.05071732798522604,0.5992216677043426,-0.12693418348957822,0.07351312180455083,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03304614090285489,-0.03482151436711524,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027065914432765653,0.06185836846341964,0.6623528800173113,-0.14930562777093412,0.09517379890540281,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.120048639390802,0.04597845906353259,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05093217626204011,0.07717027885062758,0.5102813719024184,-0.20343010013640916,0.10156574761232895,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.02427512756799095,-0.07607358931522909,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007166247163690291,0.062094658864564126,0.9908074861436382,-0.1219900273985236,0.12342327683126167,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12286876402890336,0.10102384888747223,0.9992761255456871,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018625540776734922,0.09985246166120297,0.8522841145290413,-0.1786951547536357,0.21594623630710555,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08106870701927614,0.007103956668336034,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0025833114409375066,0.06612103042488211,0.9688876801377679,-0.1332465669637794,0.12807994408190437,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.125726251253601,0.08057221889666868,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0042158022170484186,0.06648013600539104,0.9495220363372061,-0.12715708992101565,0.1355886943551125,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.020063276347940435,-0.01949562294457065,0.9937952805575481,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00302457647013543,0.04442443572997762,0.9458109631714845,-0.09081270318178115,0.08476355024151029,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11789459165784275,0.0797271725811871,0.993077588787628,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09607514575618363,0.05750854166643075,0.0969093913129247,-0.20971906851754368,0.01756877700517641,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19183383157987413,0.056514611793098635,0.6747953931947336,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03719679540313371,0.04573796492619499,0.4173761693462231,-0.1275806167054293,0.0531870258991619,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.01201869657574681,-0.07706398003796774,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08783797490029309,0.06242156161093413,0.16147252692476305,-0.21119062688550821,0.035514677084922036,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.18926425860838947,0.06091104787751831,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04906996063402001,0.08236243841940945,0.5522316830343452,-0.11368830655459684,0.21182822782263688,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04077502557466336,0.023154547509649886,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027722088760694437,0.03696579239956462,0.4544819423096996,-0.10077102261534632,0.04532684509395745,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09470675268522792,0.051227185924938974,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08103481675581617,0.04089290501950164,0.04937250447237589,-0.16184420619363923,-0.00022542731799310434,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.040836004840310185,-0.0725022197293246,0.5240813480471289,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010299744410000538,0.05031751735945866,0.8380916607861206,-0.1097333222863045,0.08913383346630344,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04628214836075531,0.00781937354801529,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06601677733177942,0.04500312011248596,0.14451470017998957,-0.15494845526839685,0.022914900604838,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04609038623839988,-0.06103161409268055,0.7635967032883216,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02143459555267028,0.04872121012616383,0.6606195843131542,-0.11771367479855857,0.07484448369321803,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06320832000557007,0.022038511992665814,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017579497383345393,0.04470692289145372,0.6947254643355176,-0.1059258533289382,0.0707668585622474,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03313017672526042,-0.018393502330273388,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032758015227359286,0.04488342955908122,0.46663759932150184,-0.12145316996912177,0.0559371395144032,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0281959894345265,-0.04252030182063975,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046390857416445275,0.07224975556597499,0.5218079505702735,-0.18916522454771323,0.09638350971482268,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.030068132947036835,-0.0667037833903864,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03026568988507178,0.04887909942129547,0.5367399372452655,-0.1268567777185689,0.06632539794842535,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0866205835484357,0.014229708736565774,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04902141643533503,0.04144843269140131,0.23882117436716885,-0.13092859660141815,0.032885763730748085,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09494020780298458,0.016327113260449805,0.8459452857747916,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022547909640534262,0.07490624470167179,0.7638254692148168,-0.17057182470686563,0.1254760054257971,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1423133081668977,0.06263345883140709,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05073853924903031,0.050223219273669475,0.31401926995692264,-0.14998577255690254,0.04850869405884191,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07133260742772361,-0.016375292251192095,0.9014294790115309,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0464993978963514,0.06367194327525119,0.4663633866460123,-0.1723229572140127,0.07932416142130988,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.14426524921620199,0.04043857129503273,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015771928639794597,0.05555763554826757,0.7768959713723284,-0.09401676465855477,0.12556062193814396,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05380867715693716,0.02746430869558618,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04770283244783945,0.07564207159992602,0.5292492626188918,-0.1971808315992094,0.1017751667035305,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.30700169641570807,0.18894706236459982,0.9450734236122966,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009737182413152275,0.07127358401007126,0.8915192109259023,-0.13110815014887856,0.1505825149751831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.21784620911491193,0.17738881849770627,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022007488937194265,0.05693041836408091,0.6996311257703056,-0.13450896923670452,0.090493991362316,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09212566597732581,0.0597516883180316,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01793180154953431,0.0660344415652283,0.7863447292485237,-0.1125603437800502,0.1484239468791188,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.051026360886108256,0.026706257570345088,0.9723925976809099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06366324749675406,0.053197686118543065,0.23332544171088773,-0.1687883916432584,0.04146189664975028,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17732120057333603,0.07041091287549679,0.8449482942840995,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0720229344706008,0.09110071969055718,0.4304507442652271,-0.2520491158345657,0.10800324689336406,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.4181287794617788,-0.44514837381832306,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007212421498603402,0.04596156852975671,0.875519499164725,-0.0980381109115481,0.08361326791434129,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.0030777933943520264,-0.033357372840498355,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0173954069030578,0.044514502541611614,0.6965213113227373,-0.10536151666710059,0.07057070286098499,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.0072488545631770734,-0.04454618305521015,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0054043929956406386,0.0659450676732035,0.9347948546759819,-0.13571992456685408,0.12491113857557282,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.22014200391199926,0.1824042035163344,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01580785495911738,0.04509832267307934,0.7264470266865631,-0.10492766481717201,0.07331195489893726,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04781338783807672,0.01516340495633824,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050370759023461456,0.06120034060780858,0.4118054364601518,-0.17131012871473933,0.0705686106678164,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15216660343937724,0.06237032075088801,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016796485722488503,0.06532163862664789,0.7974316272371567,-0.14588004513163771,0.1122870736866607,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19403619098229516,0.14384485163139632,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055062491384696044,0.048986738251406765,0.2628207530565721,-0.15186628673156125,0.04174130396216916,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.005204440083859158,-0.09214043776416334,0.8670850705749964,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010573016245025942,0.06917636762050164,0.8787314905766542,-0.12612795983562272,0.1472739923256746,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.01594042325113511,0.007425221122983536,0.986191362849829,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03193182517271469,0.05361147138940111,0.5523418225655254,-0.13787465970048338,0.074011009355054,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.019176377747032555,-0.06376946102668388,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023187179204294806,0.06576140414533181,0.7248932940372816,-0.15313976914682645,0.10676541073823684,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19380300677285078,0.14797690579699652,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012447138201411485,0.07482490827015617,0.8681084092016218,-0.13541604611305244,0.16031032251587543,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10307232625083075,0.05962764524134355,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008147544369598187,0.06543400857758118,0.9010761356553598,-0.13745316056639176,0.12115807182719537,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17505366555682417,0.12402728722092908,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004028724491707197,0.07130785596380135,0.9550215900352816,-0.14494178263240376,0.1368843336489894,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19257585336627248,0.15063406583243585,0.9948722834429907,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03583760158079298,0.0753426414756073,0.6350168057101377,-0.18472389012823426,0.11304868696664831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.170285003561334,0.07316752587498264,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008026952266854254,0.04033538164303533,0.8425317768611725,-0.08773460721973254,0.07168070268602404,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04166823347997947,0.0010960701557094377,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024118706245065895,0.08897837888706087,0.7867206134422425,-0.19995088220814947,0.15171346971801766,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.2936708346619423,0.17608645970291503,0.9724156299569652,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06323397584652113,0.06583861785491005,0.3384007869522132,-0.1933391495373649,0.06687119784432263,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.024155239419062866,-0.09565501451816008,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0029933685938792007,0.046316248071037174,0.9485566787772071,-0.08853321103861074,0.09451994822636915,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.003592558895194235,-0.025846277007361876,0.993730344541434,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07503992785121391,0.04024165156140306,0.06419915484772255,-0.1545623606814514,0.004482504979023583,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.07855268492974896,-0.17805930049712365,0.5879399282333936,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0027140671863417837,0.04400526993907916,0.9509040981794472,-0.08967387095004402,0.08424573657736044,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15030083180207762,0.12584812702521198,0.9939790270408811,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0609532574611227,0.04138892071419135,0.1429567662673114,-0.14274283467040239,0.020836319748156994,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.14147076516509607,-0.21198996128200753,0.7607934302264618,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024847298731798438,0.05481137538118977,0.6509795716146782,-0.08346669306430829,0.13316129052790515,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15985627910160125,0.17941535706449244,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0478765443504788,0.039156154376109455,0.22338349901544222,-0.12525390177611445,0.02950081307515686,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.06545557680441359,-0.13204590963914828,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013543016872596665,0.038255956779956274,0.7238347243312826,-0.08914147357978634,0.06205543983459301,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1227001972650005,0.0786646062308877,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060444526601748434,0.04906145938430638,0.2198967174276675,-0.1573959800600841,0.03650692685658722,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.022798596722753892,-0.11484438558077159,0.8339173235202663,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02987265306954079,0.04849521762234246,0.5388461943705316,-0.12570514344524195,0.06595983730616037,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08687708009598612,0.04251009107855526,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05609315166167089,0.05543564494280897,0.3132560452804967,-0.16564077658056522,0.05345447325722344,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.027297378383846813,-0.11123354153920097,0.9010715492787081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017391348967938015,0.03965731768035497,0.6616338308672663,-0.09575906647206184,0.0609763685361858,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04492044176508679,0.02533603671785496,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03304427719216281,0.03571528692720584,0.3563608349119832,-0.10362205905451241,0.03753350467018679,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.04997627185979195,-0.1049809348346698,0.9113377279417921,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057616555793324614,0.05314093226052998,0.2800295452936831,-0.16262954736441054,0.0473964357777613,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.16233088199178428,0.06853905151469367,0.8758370884717323,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06088319550653311,0.052448341015902705,0.24758317708701358,-0.16452754194023833,0.0427611509271721,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.052592648620480326,-0.12477717225281312,0.855600896698613,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020697684839389024,0.04546248565085397,0.6495825199116481,-0.06914175567038365,0.1105371253491617,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06094609777517061,0.060482583887508615,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03935326600570777,0.059981359716979155,0.5127839045344735,-0.15788378013934495,0.0791772481279294,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.07258811177787079,-0.1437372900844564,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022114924184365368,0.061406689084721126,0.7192568508508804,-0.1434620637423909,0.09923221537366017,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09175996461277434,0.06783467161956838,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08849148788778581,0.04218373893171342,0.03762565822627607,-0.17185172325503661,-0.005131252520535007,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03391996801936138,-0.07204122147480119,0.46506124338146493,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012389340622275435,0.04745206788323931,0.7943847601323355,-0.10616043933433837,0.0813817580897875,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.022883576259937206,-0.025635751070682593,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050839387220187646,0.04461655188047344,0.2563464892623151,-0.13900715897821264,0.03732838453783735,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.011410840330857196,-0.083988398827402,0.8646722506638599,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04062027260266765,0.04787209146280963,0.3975205206905833,-0.1352213893581633,0.053980844152827986,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1570149884737759,0.07742610066149914,0.9212557438608796,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10213021418073495,0.09673063507907151,0.2939732549112821,-0.09013239718579782,0.29439282554726776,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05031069141992622,0.10351134673125854,0.8803348634474737,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1231872547201742,0.08896983393267405,0.16971698616110775,-0.05364992401601304,0.30002443345636143,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.027898672116415568,0.16378377753049786,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08538567025739591,0.06773397590690683,0.21082223201530045,-0.04924294120012668,0.2200142817149185,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.02927502939685044,0.13408603804554817,0.8252886794984905,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1601672562981172,0.11295401950674212,0.1597666915832735,-0.06434108831225682,0.38467560090849123,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.18230956354276487,0.05893077537694716,0.7815068115919459,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12608955054157173,0.07376760143462158,0.09096384901273065,-0.020531544982843902,0.2727106460659874,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06901183872279044,0.08850530391633028,0.6643433245175604,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10489138646892238,0.06188311845659377,0.09365352847399021,-0.018108012265960843,0.2278907852038056,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.11401541392511068,0.21598170314013665,0.6704521782043941,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13482347063278938,0.07527773514557633,0.07676887019576781,-0.014799179161826742,0.28444612042740547,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08900806719281087,0.1143718694407517,0.630187478401246,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14224624513807227,0.07908279742363965,0.07553401759889292,-0.014939377952384675,0.2994318682285292,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05311423207975453,0.18625924825666748,0.6286648421036044,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13672385772320655,0.06314462823611687,0.033105965203679866,0.011217071703237602,0.2622306437431755,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04597614178053869,0.11451224510700458,0.43476822754237954,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18193483812315725,0.08960766062103234,0.0453751275612332,0.003829909778970547,0.3600397664673439,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.17680186484043883,0.09031532340632233,0.5099902114773299,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14895610381625318,0.07599093455221169,0.0531747522630172,-0.00208410702541581,0.2999963146579222,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.013897325444416297,0.14543206306226117,0.5411630668077272,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16904337901004296,0.09833593863648628,0.08916347381665264,-0.02640994700167179,0.3644967050217577,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.20505874411132174,0.04070760111427068,0.6623259037556665,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1539779546150697,0.07830998278382052,0.052456583608587855,-0.0016716156971494922,0.30962752492728884,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03995461702974988,0.13626181859415532,0.5393787055504797,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.108621763333562,0.06954321802925555,0.1219344684354053,-0.029602912749740667,0.24684643941686465,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03803269105288839,0.08205716026111957,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004175248611738382,0.18755627019120819,0.9822904882578338,-0.36861314728426425,0.37696364450774106,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.22652741158491665,0.2147195151931015,0.9987474789101741,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04727304209799877,0.11008928641258679,0.6686890808165148,-0.17154133528988985,0.2660874194858874,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.3188620428077033,0.3181338242937351,0.9604336667767839,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12434021985606553,0.05789413139438805,0.034516796721250464,0.00926936484117405,0.239411074870957,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07345770889726112,0.06779647302264481,0.44697280974434944,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11178338170279062,0.0798137758857829,0.16490447033833522,-0.0468551402326855,0.27042190363826674,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04570426040488066,0.10397046132849205,0.7824698350312412,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11328663338915446,0.05959036532893147,0.060600766790647395,-0.0051556702415479355,0.23172893701985686,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08536918483806188,0.06124997196812119,0.5719962981975731,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08842328380166413,0.0697065405465665,0.20800045924737068,-0.050126013469615774,0.22697258107294405,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.036489409159084024,0.07243699570386063,0.8210381131305959,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19148269432893664,0.1058148125116299,0.07381090801413757,-0.01883570333397372,0.401801091991847,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07664138247238177,0.13988123703665173,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08619132679437738,0.0995131420109351,0.38880115529730286,-0.11160181839350644,0.2839844719822612,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02689511755875322,0.12863209726905186,0.9192918506885728,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11190283428083311,0.06897581937016434,0.10834718182744676,-0.025194075528697346,0.24899974409036357,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007683128001878942,0.11281412115326278,0.6975344114730515,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11139909333856537,0.12075003579505342,0.3587882702156667,-0.12860467780985949,0.3514028644869902,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1355127330626821,0.040340835138383165,0.9133814160475374,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1275102261928946,0.07240377064986005,0.08173522014948328,-0.0164001079690429,0.2714205603548321,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05445225767765355,0.10932665279424353,0.6428846031996515,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12092672333992273,0.0754844152637464,0.11277845662942346,-0.029106725569208056,0.2709601722490535,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.060715351487891374,0.16744350096809904,0.7080335255008432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12573243781814192,0.07468855469966318,0.09587842599048028,-0.0227191520428269,0.27418402767911076,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.003549503111023226,0.13445559830531809,0.6734224093863465,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10477940109165168,0.07567817485039158,0.1697342269513552,-0.04563916597653231,0.25519796815983564,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.09979820616834392,0.16551125396491806,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09526600066903092,0.08030594244254717,0.2387380311487906,-0.06435075559059104,0.25488275692865286,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02920598100729413,0.08727209453226979,0.8459452857747916,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1139142315746719,0.06769857923719527,0.09602513201663627,-0.020644025168991303,0.2484724883183351,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.013462133595945074,0.09563054157136096,0.6734224093863465,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10623061602750339,0.07334198825137651,0.15109184549477636,-0.03954452720914087,0.25200575926414764,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05666966835981328,0.05552638479658642,0.7686319965021204,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14451087057471537,0.08337158370095571,0.08657900518357871,-0.021199179638500543,0.3102209207879313,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1033572705135475,0.12281760565110102,0.65578639613287,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1234303042707163,0.09552103053451313,0.199716823493216,-0.06642808708560446,0.3132886956270371,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.13424030940954837,0.07514671267340814,0.8150559640549688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11493685448027964,0.07696488409086205,0.1389589370028625,-0.03803918653026066,0.2679128954908199,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04900566998106405,0.07626254789285541,0.7544842968048717,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15002285843617508,0.0847194149331963,0.08009305402194591,-0.018366152296426658,0.31841186916877684,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10322493049270653,0.10079052667178244,0.6378354016929029,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05508389241937559,0.06122357523695244,0.37075448496050023,-0.0666045927500826,0.1767723775888338,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.04940529961082781,0.1277331304475027,0.9150244079451123,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12332477359130253,0.06873308941808869,0.07624594550679863,-0.013289684155292636,0.2599392313378977,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.045902108334942404,0.06834881315130042,0.6296189902384475,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01217073341921424,0.06475340470830086,0.8513495352854141,-0.14087513687852174,0.11653367004009327,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.055392687606844584,0.04649559049643923,0.9832743004559027,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08975679348272228,0.0671027592093569,0.18451245773796882,-0.04361720643927275,0.2231307934047173,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02778455492189885,0.07593042008753367,0.8047111541643488,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09934975106027939,0.05058789242828335,0.0527341913106474,-0.00119916287831362,0.1998986649988724,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007790730274725735,0.0859788230196526,0.5404408711479688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12534782146708542,0.06598118223084071,0.06077864935618311,-0.005796922763971174,0.25649256569814205,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.027066722102365378,0.1058409549131628,0.5729939650705244,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1159614455259753,0.06133986890160024,0.062023457095674264,-0.005958185894433199,0.2378810769463838,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.055583107804416214,0.06670088937271511,0.5802376411176683,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12113507872046027,0.07412454369488396,0.1058284079408475,-0.02619547819650199,0.26846563563742254,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016093791718494732,0.12114327036593318,0.688943585244993,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11162527925074653,0.07267713625394215,0.1281902889409859,-0.03282839864976614,0.25607895715125917,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03232087707924102,0.08491538906831787,0.7289215713564084,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0678978567006581,0.05731081339117499,0.2393504343964494,-0.04601359062024711,0.1818093040215633,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.035630249856109235,0.03484693709961756,0.8459452857747916,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14701705299556322,0.06430762467802376,0.02467462331192689,0.019198685616201527,0.2748354203749249,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.002652241075742893,0.14081958052393084,0.3709605300190827,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10464576212912327,0.08377517191496048,0.21496936304284053,-0.06186646336060028,0.2711579876188468,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05320475105700721,0.08197767813800763,0.8291675431652421,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08130746685512981,0.05872937399162011,0.16976359022652046,-0.035423523263156065,0.19803845697341568,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.004592380584858661,0.08985109286159196,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0931392298998669,0.05623473709224048,0.10127218545716311,-0.018633399257654365,0.20491185905738815,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.004087022491993319,0.0716875092817989,0.6834764281602781,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05782705988702817,0.06410522657582869,0.36951315080590763,-0.06958901934823271,0.18524313912228907,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007979258262566203,0.06038737700103657,0.9150244079451123,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16739686549017385,0.12589962697226997,0.1871239653422763,-0.08284227572888464,0.41763600670923234,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.08259376065359209,0.290111799044285,0.8085168201280608,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054792070725046244,0.0796376194612096,0.4932721766392907,-0.10349632124209288,0.21308046269218536,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05070699099456412,0.05317674444623184,0.9421219642690486,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17199190655795224,0.0806484445243858,0.035773877277464304,0.01169439032400632,0.33228942279189816,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.043019672798222434,0.17328660380142957,0.45290755634531366,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15031260080996384,0.07361390170345104,0.04418953447675103,0.00399700014410076,0.2966282014758269,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.003327108037304628,0.141254609742903,0.5034452685637203,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12197744761823175,0.07612121653907189,0.11268959847560993,-0.029321712779462453,0.27327660801592596,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.015126903996203882,0.11963703978210659,0.7080335255008432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16057686305713945,0.08281707006294552,0.055750728714168925,-0.004031031256913342,0.32518475737119223,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1338874374991847,0.0633799235729837,0.5511199060187707,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1428686710168578,0.07183577771432702,0.04986316883121153,8.728431746984899e-05,0.28565005771624574,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.02710241634899806,0.14602935251460009,0.5251695931527756,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06813640882847996,0.12004337224615053,0.5717696288810042,-0.1704627919978484,0.3067356096548083,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10470970550922552,0.0382191688153071,0.9525219182038099,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13594751122645582,0.06758689596418244,0.04737311724361487,0.0016112370811478816,0.2702837853717638,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.052839529462781,0.08929986582689202,0.5160635391563032,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13790419763920567,0.06497113244862504,0.0366336218549299,0.008767036720098154,0.2670413585583132,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08269218287435373,0.07740882736107894,0.4586714357798637,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10184073689498313,0.061659682856373285,0.10220932332482349,-0.02071455939050003,0.2243960331804663,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05782553140530198,0.13670893717661212,0.6839279097893172,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10689654440786422,0.0641381399365466,0.09917822542439395,-0.020584953695734487,0.23437804251146294,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.0978662965469658,0.039572866793886184,0.6779844217208436,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10759024334930349,0.05527424055163811,0.05482400443762675,-0.002273294929678843,0.21745378162828582,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06902307602517271,0.08235451813298657,0.5490443949486614,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14580944479985877,0.10799448530730532,0.18046792049651061,-0.06884128856289046,0.360460178162608,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06066232920197762,0.15308659131085045,0.8012048953586696,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05204360028386355,0.06860173453848373,0.4501219666241737,-0.08430977541620167,0.1883969759839288,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.059178241707026784,0.13645452389887555,0.933731420853472,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15803144935308389,0.058163026185752316,0.007946705119094457,0.04242613682400062,0.2736367618821671,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.028126555609309146,0.16087167520712334,0.17920723078230624,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12035569957227202,0.08176991964461312,0.14466090298521095,-0.04217086989823385,0.2828822690427779,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.022179503728376543,0.139600566378706,0.7635967032883216,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11700386323989617,0.0756173484423615,0.12541737313041462,-0.033293804755947926,0.2673015312357403,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.07881578435388584,0.17588639255022046,0.7261583573371491,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10996888556770455,0.06210431146715019,0.08011109794505218,-0.013470158226790235,0.23340792936219934,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.002269079904797038,0.13587273246449239,0.6378354016929029,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11039647782960557,0.04670928504525784,0.020331927547065694,0.017556716046546572,0.20323623961266457,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.07652841137724267,0.19453757210072986,0.3287017803075021,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09994320794362402,0.06626447458949265,0.13511427218567182,-0.03176461052560009,0.23165102641284813,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.052257518624741886,0.05907321545859193,0.7471520865805139,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12859803567991152,0.07554239111561893,0.09226435635307662,-0.021550646512533272,0.2787467178723563,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03933076676910455,0.08883672744839893,0.6674195391201606,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10779496252031594,0.06043758515569259,0.0779798812474822,-0.012331282254383319,0.2279212072950152,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.032810358789098916,0.09108951434194573,0.6337247675321748,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20730398424322483,0.10592221778516998,0.05353799315813769,-0.0032278930308601572,0.4178358615173098,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10033793072792581,0.14933256785181775,0.5420721807261442,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10590711108623335,0.06511721057977636,0.1074799518672478,-0.023520395936109578,0.23533461810857628,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.06559517250576145,0.18553615814787336,0.695334847532366,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13281185136120038,0.08523296061794693,0.12281114316631314,-0.036597887027386006,0.30222158974978675,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.17455579568552926,0.0012224316870185316,0.7232009306040013,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13438146494744577,0.07404056701901508,0.07297441741750138,-0.012782179233099183,0.2815451091279907,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007253615769896801,0.12559715217359174,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0850663297011305,0.06386526214711949,0.18635040681786647,-0.04187279424834116,0.21200545365060214,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09946408124603637,-0.0029588902363910704,0.8085168201280608,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08980120576084999,0.060148305628221814,0.13905589152735934,-0.029750064629354173,0.20935247615105415,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08039020954039057,0.03843307374229773,0.7544946458948588,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1263889352242329,0.0548873896787623,0.023682279032504597,0.01729430494391848,0.2354835655045473,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08506590083700159,0.06631706286189495,0.3634085581572868,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1256185591739082,0.06215121591846934,0.04633555543079339,0.002086287703528103,0.24915083064428833,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08432471624135139,0.0604374727756956,0.5160097508806438,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06327426384418358,0.04184340920205666,0.13411525322398943,-0.019894042815744556,0.14644257050411172,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03028683097117315,0.040182067409501324,0.7444803357286909,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11588690158241274,0.07505939068114559,0.1262336477751092,-0.033301764946461726,0.2650755681112872,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.012184520684185782,0.09573933066024311,0.7263564310373228,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07769433008210608,0.05635485382127033,0.17153348238646388,-0.03431704408079231,0.18970570424500446,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.057036017847680545,0.034961104085300225,0.7848027568782422,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1284957287737568,0.0690163109435367,0.06600516765427918,-0.00868166242234314,0.26567311996985676,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.025642635279923363,0.12647439576444583,0.5947207955047311,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14689500269505168,0.07342328429186669,0.04854687300432523,0.0009582747750687404,0.29283173061503465,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.014016939320975107,0.12600006106709813,0.5221749023148153,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1445290035724349,0.08827654676598608,0.10519475054389103,-0.030930191849723898,0.3199881989945937,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1684528684179818,0.034800296672754256,0.6885877821127975,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07938579026030666,0.09154627519245591,0.3882367013433744,-0.10257234446085077,0.2613439249814641,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04464954011432024,0.08889455074748677,0.9192918506885728,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15095233171734596,0.0748493143817619,0.04680521658950808,0.002181214580892099,0.2997234488537998,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07963734867836406,0.09814288640599554,0.5160097508806438,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08602949078302236,0.06600402569587845,0.19587780893604997,-0.04516065730832344,0.21721963887436815,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.039609409988774165,0.11730022973605679,0.8150559640549688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1921396737100679,0.08939580552841674,0.03438615304702175,0.01445583030246081,0.369823517117675,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07218131157760876,0.15246912324828824,0.44600863216872333,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11427729724534674,0.06740038116507709,0.09355692991155673,-0.01968825854062048,0.24824285303131396,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016213981570451196,0.0981123237537978,0.6704521782043941,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13036685815325577,0.07545485942651099,0.08758194391910924,-0.019607845329016604,0.28034156163552815,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04466379346117894,0.10270339405397734,0.6570553152600204,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14306997350382109,0.07241810462139371,0.05136837708296925,-0.0008688509786447807,0.287008797986287,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.004090854149435378,0.15201318143002432,0.5316325649082267,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11617399011997627,0.08198788707841642,0.16006416043235694,-0.046785813227073744,0.27913379346702627,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09080992984161804,0.06726452966563644,0.7815068115919459,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08316577561188182,0.05557627468049866,0.13816177770015095,-0.027298088202946283,0.1936296394267099,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.03099927246502672,0.09331051480573184,0.751698554752432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09699177322747798,0.06375418202503666,0.13180097691858644,-0.029726566951421923,0.2237101134063779,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.09056525426353584,0.1573739040370878,0.737305253544566,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1327117781473847,0.07620367744343275,0.08512351770067807,-0.01875128222672448,0.28417483852149383,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09159199328671717,0.08029283739884306,0.6528603705391135,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15147559860213725,0.08167411392683507,0.06703607085220857,-0.010860546630289375,0.3138117438345639,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02988605457717733,0.14871732839376017,0.5974084401217474,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0895983512624432,0.06492005368130474,0.17108173140774338,-0.03943728507572511,0.2186339876006115,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02219593575198567,0.07027608026624481,0.7845446469755442,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08385298099148245,0.0773801754099206,0.28151434797373626,-0.06994849648409068,0.23765445846705557,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.015252068077949524,0.07308135792793896,0.8768618853741261,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07426082917768552,0.061707728176809064,0.23207503135441498,-0.0483899623845874,0.19691162073995844,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.023256711785882483,0.05995619490482835,0.842940686827401,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08346500288230085,0.07477812819293288,0.26742329537014153,-0.06516462399570166,0.23209462976030337,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.014763075493239596,0.0698803260736079,0.870012817074135,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06756084698068665,0.08027301169620638,0.4022979332479386,-0.09199045585478946,0.22711214981616276,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.09482675885587721,0.14909557758080833,0.9228083763617502,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09172041857745221,0.08315322483531443,0.2730563729596129,-0.07355561974605669,0.2569964569009611,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.012577117418240807,0.09374324114452834,0.8700354117066056,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12259972158391813,0.07709263403595543,0.11539668743984921,-0.030630236275462297,0.27582967944329856,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.11680747395045132,0.2174274929595019,0.7149749731852754,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07719257438057049,0.07930822123230016,0.33309090317335177,-0.08044110293884744,0.23482625169998844,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.01602271048320572,0.08434825529006128,0.9034998483867911,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10232582585817875,0.09117774378934454,0.2648364435921921,-0.07889981279412887,0.28355146451048635,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.12553147628376907,0.22697037000120873,0.8693121373799397,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0756274325272992,0.051924092456004114,0.14885413026233318,-0.027577323652251143,0.17883218870684953,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.035292989476662144,0.055935363371369375,0.7662201971017615,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06175190872596137,0.0565001306878472,0.2774322047657214,-0.0505482189400685,0.17405203639199124,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.019209687560530028,0.04254961286659829,0.8732184145243047,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0893153105652668,0.06606563746585314,0.17990586140821976,-0.04199729759032407,0.22062791872085769,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.006012447122537815,0.08901952869405412,0.7996039909621772,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10509357012549603,0.06707668851584828,0.12079930713075772,-0.028228611470174497,0.23841575172116655,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.031239760518847217,0.08975830195523561,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18232617446135194,0.07725941984226992,0.02051582290551649,0.028764711752089306,0.33588763717061454,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007918552887750183,0.19476401279083497,0.3296651866882387,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06714472313835995,0.08491709826253824,0.43126395822754726,-0.10163720461677389,0.2359266508934938,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08058478909743982,0.03953293827238658,0.9302388919528202,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07453119613458828,0.048947268434766274,0.1314645916260982,-0.022756799967516464,0.171819192236693,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.029965907717355036,0.11119631265989222,0.7364614878814166,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1144861341322016,0.06188262110709137,0.06770058442353329,-0.008512276066691804,0.237484544331095,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04614733869661719,0.08180215663777844,0.5997848651272403,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14107035651966138,0.056513115202148245,0.014437083899750267,0.02874442072547434,0.2533962923138484,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016061227767634016,0.14395008411198193,0.26284764219315965,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16032925108319673,0.07350438681230838,0.03186473210449298,0.014231323121926154,0.3064271790444673,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03888048287132045,0.13390837132442332,0.42726730311733996,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11418771137056485,0.06471517462983677,0.08116339655872364,-0.014440705668181592,0.2428161284093113,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05018155125752949,0.09773220365280726,0.6405850327149293,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1479517913437871,0.08363267321061234,0.08038722465504916,-0.018277202541058357,0.3141807852286326,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03578793603747932,0.12877001715396585,0.6387525418536338,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09387183593930573,0.07942185101928202,0.2404501507303844,-0.06398769288575257,0.25173136476436403,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0720340173672579,0.1542167133674339,0.8475547497769944,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16346270437447374,0.10659860030754766,0.12879574703762117,-0.04841355640261119,0.3753389651515587,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.11587234194361969,0.08183490785302362,0.7302718857033121,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12477243436111998,0.09353405689915971,0.18569241510736229,-0.061136631742273184,0.31068150046451315,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.031144707284100185,0.18699749536822258,0.8073060060237306,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17500152952674397,0.10499902722855685,0.09917113051028002,-0.033695406551531915,0.38369846560501986,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.18430832317862492,0.043759774255661577,0.6779844217208436,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1545005783423154,0.08765694814951736,0.08148679818873712,-0.01972709773848902,0.3287282544231198,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.027395564282304795,0.21265131097146722,0.6423457835374332,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09000959237423609,0.08147118466628472,0.2722911497750454,-0.0719232089793439,0.25194239372781607,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1141421651177255,0.0099597988921947,0.870021716674458,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11250888926206358,0.06762332039610751,0.09975885671075149,-0.02189978238579081,0.24691756090991795,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.001574738964874208,0.13118371992258696,0.6779844217208436,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12074529708555062,0.060549431053905936,0.04926588540568814,0.00039674647730075785,0.2410938476938005,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0333286615709749,0.13731801045987307,0.5240813480471289,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06731754349775407,0.05199727674632261,0.19887140864956004,-0.03603267438331555,0.17066776137882367,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09386519142191917,-0.0023152969748718973,0.8150559640549688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13817857164413636,0.07723628472151456,0.07708916424041856,-0.015336907507517372,0.2916940507957901,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.024368864265610937,0.14919854221721665,0.6308595729282912,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12889858705166768,0.10482323229830286,0.2221336406706109,-0.079448937567374,0.3372461116707094,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.12242338339322834,0.06404036596376189,0.8355377918591873,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10760129380697701,0.04659309508199907,0.02329121841318875,0.014992472157128678,0.20021011545682535,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.01481358984603911,0.11944747317731957,0.36040095860407856,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08651443832773034,0.060713521349687084,0.15774589602974454,-0.034160259511342536,0.20718913616680323,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02321566212818014,0.053644149824931035,0.780274991675152,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08946378785495049,0.07429223763133726,0.23177268539353252,-0.05820007891887863,0.2371276546287796,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007588262566149609,0.09730061984009564,0.842940686827401,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0806287780101623,0.06519012070040622,0.21948032437902482,-0.048943645771756195,0.2102012017920808,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06605027081384067,0.019138822561074652,0.8339173235202663,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11102532557636018,0.061356930324738004,0.07382697581453171,-0.010928217269972645,0.232978868422693,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.021423777095782824,0.14697223400726223,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08446891274318921,0.05799594801524813,0.14886447445782244,-0.030804313830527175,0.1997421393169056,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.01762465840576307,0.05590425440046656,0.7662201971017615,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08952835743068324,0.06122450981997837,0.14726315313758723,-0.03216198532373714,0.21121870018510364,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007795003094959328,0.08908411659675623,0.7662201971017615,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16104264572066357,0.10473096473874612,0.12775620505551388,-0.04712148713288111,0.36920677857420825,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.062055259550083036,0.12516534113489894,0.7288842902994255,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1794537732768949,0.07266790628595311,0.015483345821752464,0.03501844093719603,0.3238891056165938,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08164460996081095,0.1335564749646016,0.27154254286073387,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09597823602434616,0.06008824025256668,0.11382749245478846,-0.023453647927769106,0.21541011997646142,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.006013737401856301,0.10552459871078052,0.7095033877612622,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17485403510532424,0.09349866197039292,0.06482956528344315,-0.010984679744525772,0.36069274995517425,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07009097286667246,0.1663460096761782,0.588665895017662,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1764157920929611,0.07657694607066794,0.023618954554488272,0.0242108199041019,0.3286207642818203,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0031611670237371423,0.18436272673412313,0.3633474055300928,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11166426731888238,0.0703598235363681,0.11613029211745686,-0.02818350063314845,0.2515120352709132,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.04503711525379591,0.16544791158744834,0.7168291281713628,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09164964571224837,0.09972244417353701,0.3606119120550494,-0.10655951018737753,0.2898588016118743,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03180019706908296,0.1165042982699675,0.9133814160475374,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19782684893824404,0.07408195534920194,0.009041000207911947,0.050580940969858545,0.34507275690662953,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.013957745651057242,0.22108082620470568,0.19636616606057228,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1520485192431478,0.07926942724608188,0.05837547924649586,-0.005508050827986832,0.30960508931428243,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05161946894504344,0.17129426279794166,0.5641356117388143,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11217278961741803,0.10400595765039652,0.2837817546007292,-0.09455031314311224,0.3188958923779483,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.004823048579874946,0.14244700106120664,0.877125252431494,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12690734972169754,0.08182874384934745,0.1245584188482509,-0.03573613922529614,0.28955083866869125,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.11528105902804495,0.05725965117988663,0.7259506085296737,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10459909306208515,0.057638889190783964,0.0730115682443651,-0.009964440435111813,0.2191626265592821,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.022764536126778534,0.11314518843171238,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048236491228107234,0.18568231173030422,0.7956475010713903,-0.3208272093116488,0.4173001917678633,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.34495056862696305,0.1859959766014379,0.9735235918682278,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0858223225985781,0.06123909927378373,0.16464281797852987,-0.035897018275049666,0.20754166347220587,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07868238144773163,0.04009647809001036,0.7824698350312412,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09304158733238137,0.060672328678716164,0.12877900488700586,-0.02755123561272893,0.21363441027749167,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07976209447810831,0.044145625390239834,0.7302718857033121,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12084942184803828,0.06458650017027558,0.0646889912537979,-0.007523240769255354,0.2492220844653319,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05487489889759817,0.21600171269974577,0.588665895017662,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07943287685646383,0.05980616749061683,0.187595123882213,-0.03943835693798921,0.19830411065091685,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.028297623151883687,0.07803633354420744,0.8085168201280608,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10801867470074963,0.061942985379734875,0.08471918077835698,-0.015099716026362106,0.2311370654278614,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.017204742923624762,0.15037865607186995,0.651648117266083,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11541677615009978,0.07005263423326157,0.10304776106073163,-0.023820419799060924,0.2546539720992605,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.03956627637160921,0.19005218096833315,0.6839484127328216,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12783914481044123,0.06042010027469602,0.037216357481559374,0.007747653130013354,0.2479306364908691,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08549260136752836,0.05419498713896726,0.4631727895701855,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11695525191124376,0.0729885896607995,0.11269699804035913,-0.02811747336006773,0.2620279771825552,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09437061357285818,0.030017703323767377,0.7080335255008432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1086935102125335,0.07487704349205047,0.15020206750532375,-0.04013272153317103,0.257519741958238,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016939312445363924,0.09602491720207595,0.7680634195565342,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12165662614677422,0.07756935888393313,0.12042745726659122,-0.03252087396848599,0.2758341262620344,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.04621819150973527,0.1821999673977878,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14543754099333808,0.08553651062300091,0.09264729857385563,-0.024575535899170026,0.31545061788584616,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07427232842200614,0.15211996725710036,0.6679693515706321,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13944059543618784,0.07633583527044198,0.07117849001138045,-0.012285142929361698,0.2911663338017374,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.03151105153271395,0.20040835783229835,0.6185936355341891,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09353942987523074,0.07837602803300396,0.23592973738018191,-0.06224141252122507,0.24932027227168657,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.019859598068624442,0.1283633257809467,0.8449482942840995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16919735331367855,0.08705164960572938,0.05517090995284017,-0.0038272263686590924,0.3422219329960162,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07334587148467982,0.15979355894153,0.5501842753839765,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12093050026482008,0.06163421556537397,0.0529511814966344,-0.0015741770221632118,0.24343517755180338,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03235547551094787,0.10087657780789927,0.5409607190737244,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1951870670171183,0.07804059588223744,0.01425402348418861,0.04007293234143727,0.3503012016927993,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03993315397227031,0.1798170919988612,0.26131279080251546,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13957667713038166,0.08058003798710779,0.08679092991976743,-0.02058487370355566,0.299738227964319,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1334673468119465,0.051758966855539164,0.6563443622796822,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.082282454534126,0.06006936057791822,0.17427726789966919,-0.03711190402030429,0.20167681308855628,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.043272873342441204,0.03698101168331013,0.7896200758961603,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08568335218968981,0.07779206008025663,0.2737427819043106,-0.06893679066770278,0.2403034950470824,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.027970472053635544,0.060219646683014647,0.870270919138952,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05721258065293196,0.06396942046216993,0.37358948749912946,-0.06993356922613032,0.18435873053199425,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.01764153005794098,0.06362018814517846,0.915824547329523,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06274576214242089,0.09205730269638848,0.49730575194992044,-0.12022809507767271,0.2457196193625145,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.1321465181270195,0.10157581554640044,0.9438001947036577,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05464341524010119,0.0722390924517817,0.45143823968350905,-0.08893960317153862,0.198226433651741,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.029159172885353427,0.05330301713027465,0.933731420853472,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10645200236586666,0.0766328634333185,0.1683426808733264,-0.04586411163608142,0.2587681163678147,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.019231618986656013,0.08151265304954479,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061493822241155904,0.054834801497936604,0.2651873353936753,-0.04749628333543565,0.17048392781774746,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03187586250327746,0.0516403374690231,0.8693121373799397,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1230939230515885,0.07856722854166046,0.12080719819739485,-0.03306695105931698,0.279254797162494,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.021588117734342917,0.08062664051764552,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09047354594198541,0.05581675149162286,0.10865743822350839,-0.020468291574163272,0.2014153834581341,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.00010039481389055497,0.09368053666497404,0.6983913976492675,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11703629068960988,0.06876671175147445,0.09233910213949008,-0.01964499508526918,0.25371757646448895,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10160352745582654,0.018649703817591488,0.6674195391201606,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0660285799372034,0.05716593070555519,0.2512391558616217,-0.04759489735790501,0.1796520572323118,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.013539244842372074,0.07621815574111712,0.8585176148211594,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0957807539289711,0.05456775878786461,0.08273445855241737,-0.012678575345543355,0.20424008320348558,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03256124754257037,0.035687619164391275,0.6457680747188683,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07669530100197335,0.06782375885437168,0.26124574434441117,-0.05811176378547585,0.21150236578942255,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05230075191429863,0.06140708567376573,0.8669652730965864,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11640474132482309,0.10478371410738328,0.2696700778886585,-0.09186423661067342,0.3246737192603196,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.13562167756007845,0.17564011152072465,0.870012817074135,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0941222689277206,0.05579331728368601,0.09518962868936585,-0.016772990562660323,0.20501752841810153,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04225125001827686,0.06374900256077717,0.6734224093863465,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13806796732408655,0.09167240767086243,0.13566342100000223,-0.04414086935572903,0.3202768040039021,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.006289979000256506,0.09520727568262065,0.7473242853882033,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07481095076765991,0.0682435241237404,0.27600110528901634,-0.06083044294551003,0.21045234448082983,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.01865777055030387,0.09601758692086268,0.8716406527156833,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1293809023762558,0.0672633197533391,0.05768769918291225,-0.004312229012654711,0.2630740337651663,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.0021525959455307086,0.11493481981246037,0.5623055122749077,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08593305318791938,0.05427445045315263,0.11698040116500671,-0.021943294011462458,0.1938094003873012,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.0778010268118688,0.017730816238593204,0.7176009922554474,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11728538192595817,0.08488474630007171,0.1706012512249256,-0.05143224280065156,0.2860030066525679,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.011636385499692333,0.08880740007240279,0.7844207095472905,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09703384877983096,0.06651193575959456,0.14819541727199184,-0.03516582556045944,0.22923352312012135,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0362387347211516,0.13388261433610482,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008170183373717041,0.10082960083477785,0.9354622151849985,-0.20644112691729966,0.1901007601698656,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.034385072387509846,0.04592480944079197,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05050068119089213,0.11832597775142381,0.6697784393294409,-0.18217507136846742,0.2831764337502517,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.004989903197189017,0.07254009688475739,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023670268265900095,0.07334701965127036,0.747092500218652,-0.16789956870909978,0.12055903217729957,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07216327919726606,-0.09627945563918644,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015960596891267692,0.12211859310218595,0.8960856269351191,-0.22417294006739416,0.2560941338499295,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.16278317483872753,0.24435552762999568,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03281805347790566,0.10556807885639001,0.7560737538666105,-0.17477061522304488,0.24040672217885617,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06351317635950635,0.07557054765239868,0.9654293488033827,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03599743334441853,0.058919035554318926,0.5415982872089032,-0.07986073405202927,0.15185560074086635,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.11831888861457006,-0.1170606488981793,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03638613973496506,0.11827128045393412,0.7585218970554479,-0.2689543357365997,0.19618205626666957,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07146875631544032,0.039760853927871875,0.9669418369722411,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050411128276572,0.05454020500927835,0.35593619579964375,-0.05683652339240304,0.15765877994554706,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07364718509929111,-0.08484712295865546,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027545138789351685,0.06154059602874051,0.6547089021683047,-0.09346805515204748,0.14855833273075086,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0468218887941805,0.07207143781384222,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042483485712806926,0.10526932125008993,0.686762456256559,-0.24948467859314993,0.1645177071675361,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.15179856293570054,0.1546595020528517,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039158049049243,0.06864250075167687,0.5687095538908578,-0.09582030332495181,0.1741364014234378,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.019193393397666014,0.06971323702806607,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03357027497454358,0.11037406406989518,0.7611845719556567,-0.250609414718215,0.18346886476912783,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.16500268771349005,0.17642108645953064,0.9680441569078666,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002290633346084439,0.09084658169391424,0.9798976205059748,-0.18093100602470769,0.17634973933253884,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04561975342680364,0.05730921250501761,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03646238314148379,0.06902398766294426,0.5976378751002508,-0.09926612364391868,0.17219088992688625,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.027159947121909462,0.048650062971976195,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06426020147552165,0.07894886513389676,0.41619875571134934,-0.21950494956733085,0.09098454661628756,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10192419289880118,-0.14669064010642452,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07041610780165525,0.11921359305840154,0.5551009588992633,-0.16400504812101407,0.30483726372432457,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.3592686158311668,-0.38113090602386857,0.9497080900134104,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05277958769993032,0.06760791762081664,0.4354947736236702,-0.1857235397409724,0.08016436434111174,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05625394246036275,0.006280985197351072,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06310350287314079,0.08253688009715703,0.4450273720197676,-0.09919670419425064,0.22540370994053222,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03313304145802553,0.11719242556061035,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010220348434959482,0.07442856485938995,0.8908544881067072,-0.1565763952613993,0.13613569839148035,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.062498043605453676,0.0615882939093179,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047211433197311053,0.06736378529261106,0.4838415402678886,-0.08525245796218364,0.17967532435680575,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008109627783167343,0.08384823041779309,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057751231808553655,0.1343884363749533,0.6676395620151567,-0.20650967828936953,0.32201214190647687,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.011772507539848815,0.08161538287017216,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03495049764296236,0.1181318717875784,0.7675029610711036,-0.19734356568743627,0.26724456097336097,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008443860196197178,0.06444731031647315,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02320372887148396,0.05589581486469972,0.6782912888499109,-0.08670958886069212,0.13311704660366003,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10501951627807972,-0.0864388584202036,0.9621651627753025,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011934124495046258,0.09887532838378059,0.9903763754454831,-0.1932346571801429,0.19562148207915217,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.10222706203069203,0.12392297047075415,0.9991875531629696,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0240348719156038,0.06792396838951088,0.7236531162882145,-0.10953056115479753,0.15760030498600514,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.007743760464951751,0.028296627780334038,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03778729849893511,0.06362677633939973,0.5529486789612097,-0.08732815246988432,0.16290274946775454,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.001340966944573561,0.01778233429331988,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025379111094044865,0.05478053411767009,0.6434310290787582,-0.08234112281950237,0.1330993450075921,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07855061259241139,-0.06472770158287981,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04910226176077229,0.0663759650589503,0.45991493392535976,-0.08141918344874494,0.1796237069702895,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.018096426579745552,0.02018916151446615,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0280543249016095,0.07947741540159384,0.7243007935732159,-0.12822976242608775,0.18433841222930675,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.025891791065683793,-0.01648240247775032,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014856220702779623,0.05341854339569328,0.7810834143207839,-0.09018579983584366,0.11989824124140289,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08409404110476214,0.12249330763588864,0.971527114099096,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026871404116274956,0.05487977765642004,0.6246779338391111,-0.13478679014691528,0.08104398191436538,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.060918170082257424,0.025216440338302157,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04555164896692397,0.11778647455070557,0.699177884443394,-0.2771665244845657,0.18606322655071778,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05078419487063243,0.008226841798541384,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01723783155780864,0.10801746442901201,0.8732960621025924,-0.22964296273173462,0.19516729961611734,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0833745647344035,0.0867841304501692,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02083482754479319,0.092348417845239,0.8216284764456324,-0.16075875002907664,0.202428405118663,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.013487445156712774,0.030765986850240547,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041664316830990936,0.11802825675675857,0.7242872861673428,-0.27375463195891864,0.1904259982969368,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07823751094670642,0.052748930146461676,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047272012111610744,0.05844177704261704,0.41910764909288034,-0.16219170018605472,0.06764767596283325,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05289351744928661,0.017389644480323478,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004731738355032107,0.08770170897947252,0.9570020192917363,-0.16772456858045118,0.17718804529051538,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008608358547895423,-0.0037868376771660432,0.995747388821315,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05854085931845153,0.04722631393971458,0.21591591207221322,-0.15140650340898126,0.034324784772078204,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.030832055323249275,-0.03362872795909269,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023366430010506416,0.06079054650397336,0.969359509240254,-0.1172016564079018,0.12187494241000309,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04525562056013043,-0.06314087914962796,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02363803165410355,0.057482315816010716,0.6811473411183482,-0.08939497551396214,0.13667103882216924,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.032029936112596004,0.031947252310682066,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013466887629371309,0.07223309179256358,0.8522046169935691,-0.12857198930965144,0.15550576456839407,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.03484442085599225,-0.029349734269783753,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010641269617536225,0.05746263608960451,0.8531847017414478,-0.10235303941138249,0.12363557864645494,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07281968801985976,0.08801008384441618,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012075529002082724,0.07814462110239688,0.8772777215561582,-0.14158775668538684,0.1657388146895523,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03823806984474432,0.03292209300221184,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014032540453426876,0.06796588831666792,0.8365416882095673,-0.11961532380228009,0.14768040470913385,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03949477786241074,0.011998951990397088,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01545907587624407,0.0789584692330227,0.8448840272255949,-0.1398045576795541,0.17072270943204224,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03219654831897155,0.07167091914176803,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008350347006449214,0.07997164820419016,0.9168955312196534,-0.1656062918371979,0.1489055978242995,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.035959473194315576,0.028784022297310138,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020981920844247326,0.08466901686803828,0.8044180439998794,-0.1874747535476294,0.14551091185913476,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0673179132198479,0.04661334256844314,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024175206397363102,0.05603535688923591,0.6664086596081692,-0.13436291903579403,0.08601250624106782,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.042616731970039894,0.03440659499462233,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021585033681104888,0.04904460878916179,0.660114259044001,-0.07485609848490661,0.11802616584711638,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03971805451096379,0.04494549565038734,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0020757674123662306,0.09696665327921605,0.9829325105106099,-0.19275062557665976,0.1885990907519273,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.022198593925590645,0.006473573716220284,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05476720144174069,0.08565091638936592,0.5229431997886063,-0.22319083762888975,0.11365643474540837,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10464863722609608,-0.18922519457757847,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03700034317616366,0.05116883812089697,0.4700734225777681,-0.06361786546758014,0.13761855181990745,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.051222807390143885,-0.07948126193063626,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03419745939341398,0.15178068221071642,0.8218637719611931,-0.26426349675893435,0.33265841554576225,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.00937932306088742,0.035167458021800505,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05293229298369778,0.047256066741337095,0.2633907329028418,-0.039991856902768075,0.14585644287016364,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0025611611120997884,0.07965454772726195,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10640854219855965,0.07077819415416348,0.13358676116048518,-0.03276942955848579,0.2455865139556051,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07106844681093788,0.17600549848737518,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01610440996960004,0.1031061905834283,0.8759665008203688,-0.21885203093518518,0.18664321099598508,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.13624083249467334,0.09735160619204279,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028704505458649172,0.07830413301238587,0.7141439950589524,-0.12527244384186773,0.18268145475916606,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.018480226124354734,-0.01777323127750073,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09701115823254237,0.09158821734057125,0.2901951159598465,-0.08308756396061671,0.27710988042570145,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.17900909516205912,0.337455109539724,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07414918276077044,0.07278840984407538,0.3090134569770177,-0.06898166948241367,0.21728003500395454,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07077948804356302,0.14682948097423906,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00351291126141412,0.09328893334524226,0.9699820682211386,-0.18695591493693614,0.1799300924141079,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08490624069131837,0.08642026052724244,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02062650760255002,0.05927880084352261,0.7280699202871312,-0.09593910089010455,0.13719211609520457,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04771263928721623,-0.07833566859606529,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004671647164858281,0.07191706246728749,0.9482418734811646,-0.14608908524077763,0.1367457909110611,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.054867736138944,0.10073739630097543,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012540770937064072,0.09514468747829088,0.8952083012363719,-0.1996329224808532,0.17455138060672507,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.017409303334035873,-0.036318570745787385,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05957077756773209,0.09254493147356585,0.5201715342786215,-0.12240922365737665,0.24155077879284081,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07864040777409069,0.17865245321262788,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01541293110828576,0.0980824087374091,0.8752181279314792,-0.20828180656143414,0.17745594434486262,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.023666679559054767,-0.042676086336141554,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01273263984267381,0.06312848416283122,0.8402667537366628,-0.13686825097090402,0.1114029712855564,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0432864550300385,-0.08895633167012838,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01300048104121361,0.12177121647702539,0.9150360315954147,-0.25245093792551887,0.22644997584309162,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.031773314036882216,0.021301176953517416,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08653523680908098,0.07064125271471314,0.22135608187937586,-0.052373453822330274,0.22544392744049224,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.08085632682993542,-0.06472933360074953,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014866972994988792,0.09054815311985613,0.9869090847746997,-0.17954024116526365,0.1765668465662659,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.05926161742730285,-0.11067025549028019,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0470237704130618,0.06674486256542536,0.481545866109098,-0.08422307344996727,0.17827061427609087,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07315371528249894,-0.08036662625801656,0.939653659088992,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009024005653768204,0.07641812191391614,0.9060626074687204,-0.14124429859676962,0.15929230990430604,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11202663986946206,0.13142066432369384,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04806395841385009,0.08623840170545251,0.5776333600671306,-0.21764282349186184,0.12151490666416168,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07609569974320979,0.011694806250755963,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009657356260735876,0.0726692445142628,0.8943489159812467,-0.15255388225266037,0.1332391697311886,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.015568302325502806,-0.015203697295310306,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03365153037696479,0.099834044151292,0.7362517106990127,-0.1626617542911324,0.22996481504506194,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08092279672272869,0.16465703777000162,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03494476136635742,0.07447608668064845,0.639197465323733,-0.11150473218864053,0.18139425492135536,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04485106150534635,-0.05912337665076374,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011961097788874532,0.07736103084082388,0.8772099424132567,-0.16408353456662536,0.1401613389888763,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.1365927030835513,0.14358321260822915,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028564860320461207,0.06260379990005145,0.6484563696423964,-0.09453901366924478,0.1516687343101672,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06592739472427366,0.09670801151689062,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027902323829265097,0.07973561201353419,0.7265861850741153,-0.18469412799254772,0.1288894803340175,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11456593309696884,0.10109619586600031,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015731756026108976,0.06981503368558004,0.8218432412802941,-0.15301577270142358,0.12155226064920564,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0418666650816041,0.01645877205896667,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005035043942799598,0.08497196122152484,0.9527807084113449,-0.16205349738493185,0.17212358527053107,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04188528698692188,0.04553459037213163,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0081038719677008,0.08462556543471964,0.9237618305451916,-0.17451126193788666,0.15830351800248507,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07186088900653735,0.07925444662571351,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02078890015355661,0.07543683833713594,0.7830243472884006,-0.1691276121113426,0.1275498118042294,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.042201183407292196,-0.015443654275525485,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021110979019062327,0.08403091452899765,0.8017767478827174,-0.14412709167205842,0.1863490497101831,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.034797359290237,0.043624206292689885,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0028146219435486626,0.08513061355414861,0.9736426590436773,-0.17021513661466617,0.16458589272756882,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.049898758379072226,0.014114494699437444,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032493317249471285,0.08602904591819152,0.7058687729095987,-0.1366738714048228,0.20166050590376533,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.01372757444286451,0.05434780909809622,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013904546414880495,0.06652769006359234,0.834560214656697,-0.11691525026662981,0.14472434309639082,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.036389803644825414,0.0565450229359481,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033027734377870197,0.13842227870858484,0.8115468577035705,-0.30522077669662545,0.23916530794088503,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.15318117004878656,0.1727588566496136,0.9759216719362132,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03375107974079766,0.07611600426378279,0.657723787320947,-0.11592314151171992,0.18342530099331525,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05877296632837891,0.1431632049706206,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028307100201511004,0.08674030051409586,0.7443492774039957,-0.14225869678468295,0.19887289718770496,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07524786208831179,0.11853890924176012,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002443347666007751,0.05348434343054392,0.9635872255372966,-0.10272806181085416,0.10761475714286965,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04859720421040743,-0.07278148062713888,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053607539351494496,0.0981409283197733,0.5852369153543495,-0.1393764087858167,0.24659148748880572,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.09153511985801677,0.16754179396624067,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03217667711866206,0.07366139357769225,0.6624976169332237,-0.11267080701763094,0.17702416125495507,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.051711190167245624,0.07119603024218059,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04494634648644985,0.08245011629281707,0.585989929117052,-0.11718324856612161,0.2070759415390213,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.017390503884341563,0.07335455290166328,0.952608653969109,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01660227336915815,0.06238609742866733,0.7902939733484763,-0.1060735113089197,0.139278058047236,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03593818135034909,0.04908647538731718,0.972929334907502,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06566758520391673,0.09278607542414283,0.47955785786047855,-0.11678660056833774,0.24812177097617122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08534285987231476,0.1737971719975595,0.9384017168502401,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05088533478173035,0.048388307770119335,0.2936676159731366,-0.04426524955688878,0.14603591912034947,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1128590586228275,-0.10765149984948941,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09597651236793392,0.05924267610250478,0.10607197043198308,-0.020518060571395283,0.2124710853072631,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.13461932434493007,-0.07446664147785476,0.6895981173538752,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017317737035873818,0.09430266373857775,0.8543965105997733,-0.16811866222905242,0.20275413630080008,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.09166256771301805,0.12284698947147417,0.9834313824125731,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10408455243421627,0.09250870487297215,0.26126221021124557,-0.07782421294128458,0.28599331780971715,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04640603419382078,0.16271439533819643,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011804460711158246,0.0654686213783597,0.8570101539493004,-0.1169327873362201,0.1405417087585366,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0633194672845057,-0.09234263911707279,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002099996449802237,0.07525583988246205,0.9777531533403998,-0.14588280083519906,0.15008279373480354,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05263280748493283,0.030611706041981664,0.9983210449785855,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009081847809741361,0.07413159319882891,0.9025617865619211,-0.13669023507299877,0.1548539306924815,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.02745494341533705,0.04892233674790126,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029032671453447262,0.08119389340312486,0.7208674336947383,-0.1886920345941771,0.13062669168728258,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.03676062566739035,-0.12420355320006143,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02754631764149776,0.051055442734165554,0.589840674321152,-0.07284891074511333,0.12794154602810887,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1585182912110226,-0.16077662500213058,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021652962753171093,0.08818451293365656,0.8061732726427115,-0.19505865354766122,0.15175272804131906,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.007437290654141485,-0.06778888557275983,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05447792167057104,0.058693242753639206,0.35391905791004463,-0.06093624762149595,0.16989209096263802,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1703957863182623,-0.13864457580268708,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023781537487670715,0.1047225346510316,0.8204784583971607,-0.22970753127950472,0.18214445630416326,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.026035621325192403,-0.11946733477571078,0.9788034269246562,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06340763176455613,0.056304265816920565,0.26082754760162474,-0.04730886236639202,0.1741241258955043,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.15715404443042363,-0.11781205596889165,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001803277750201615,0.07780425897358154,0.981521492646301,-0.15119072114184265,0.15479727664224588,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03995832597919639,0.016186238697448528,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05712221791035992,0.06856915362896687,0.4053483189139958,-0.19195634078145726,0.0777119049607374,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.008956296609773526,-0.10959477706097387,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01946052114687622,0.07810790023475213,0.8033836183483052,-0.13413055676613636,0.1730515990598888,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03280808261864398,0.03486772113885199,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0170658346076506,0.07954922241018293,0.830250589177426,-0.13935945374859512,0.17349112296389632,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0320861389019726,0.02083263604498136,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016210576501964877,0.12399843936177954,0.8960582866721462,-0.22761948299095996,0.2600406359948897,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.014993616404705583,0.032011190183677624,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03202855121764372,0.06788245602275488,0.6373307553768138,-0.10145525209267428,0.16551235452796173,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06670541016627705,0.09365655047912723,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004484952916022002,0.055801698630555646,0.9359840121422999,-0.10524329501133464,0.11421320084337866,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.06326616424663173,-0.1033423787818097,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04012864580791414,0.0625917810029286,0.5218436706386058,-0.08295159426820722,0.1632088858840355,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04226823683642783,0.08204327503710494,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03257028893071709,0.0838073176056458,0.6977711884584353,-0.13222810162084764,0.19736867948228182,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.004448857977014022,-0.011330581801971988,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026875991787412346,0.07586836178557489,0.7233570383530744,-0.1223112662379453,0.17606324981277,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04754782109812619,0.07442701884349269,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013545784174131902,0.08082597981991547,0.8669958600597487,-0.14539011509605307,0.17248168344431689,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0311214908848599,0.026213699863051262,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020220364466316046,0.08377643719612149,0.8094090388220706,-0.1445173029654237,0.18495803189805576,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.052853336330151046,0.07238445146499098,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0019257551134509443,0.06389844302756782,0.9759734460508062,-0.12372390019761031,0.1275754104245122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0754290823151869,-0.0954468995723256,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059567372638680824,0.07028529986756646,0.3972597600476858,-0.07864137366808273,0.1977761189454444,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11737368197828092,0.18905407568328264,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05782256284026921,0.06629615536673097,0.38367266405974476,-0.07254194489404983,0.18818707057458825,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.01943384995435447,0.10508774691577849,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003568821045704197,0.08410433557981518,0.9661762044959801,-0.16895126661187188,0.1618136245204635,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08362027023693573,0.0914773680150826,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003410958545822823,0.11215953471646473,0.9757551366334305,-0.21713912388564918,0.22396104097729483,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.021106168872076198,-0.004851931046331817,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018528372964744504,0.05598171168753669,0.7408530733855823,-0.09155385195312192,0.12861059788261092,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.079241776606212,0.12218519966534057,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005679457350752801,0.07519987214866185,0.9398379626944262,-0.1421932851953951,0.15355219989690072,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.006289016788689062,-0.04488212593728981,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03816102310518274,0.048092763435815984,0.42800220619230267,-0.056408403978660523,0.13273045018902602,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.16562661859398736,-0.15107109965447918,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06470419206967239,0.10708517419361953,0.5460603184919516,-0.27527607127098935,0.14586768713164455,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08935022526433835,-0.07819580049210925,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00904546606381422,0.07583010259640678,0.9051135507083354,-0.15815749136512286,0.14006655923749445,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0038911160245537575,-0.019226438732108095,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01348556067250703,0.10690519914026221,0.8996856324251186,-0.19673241626848129,0.22370353761349535,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11531037730464741,0.1589938379900629,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055431712145767004,0.10745135641853146,0.6062482584053568,-0.15586022638972452,0.26672365068125853,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.023796085633300466,0.07288069886530094,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023619056339727818,0.07936777504457847,0.7661831233268153,-0.13244943460698688,0.17968754728644254,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008584426277569114,-0.0009673782914911278,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05026632041804627,0.0669595266899371,0.45331212788517117,-0.0814026381628784,0.18193527899897094,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05188986031754048,0.12684740434133251,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007866584641287023,0.0895877969141743,0.9300762564106455,-0.16829851843464974,0.1840316877172238,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.02048112262807675,0.004348686077624714,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06395455396035499,0.06471018160120962,0.3236403975841975,-0.06329130099420588,0.19120040891491585,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0242829086675589,0.0973551680531557,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015701518819055727,0.07752632483780915,0.8396125952779405,-0.16814898908372936,0.13674595144561788,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.003973035232247274,-0.06428983425590062,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022631043128759736,0.07477892372354512,0.7623348064361442,-0.1244139480354518,0.1696760342929713,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.056206206450575405,0.0664932616985687,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07718196590185354,0.09809843527758418,0.43191383392120497,-0.115718424078933,0.27008235588264007,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08210734103843144,0.1747802924451049,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04312137935773073,0.0947358889234665,0.6492505357323433,-0.14316691226284897,0.22940967097831041,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04660702701100221,0.1044501983840712,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016850984613308598,0.03975159720747961,0.6718798962144439,-0.06131640492745147,0.09501837415406866,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.00638455885193975,0.0034595905678368837,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005803525342635479,0.13178861808188494,0.9648989688951133,-0.2649521626383169,0.253345111953046,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.054606166406262154,0.0742575944229756,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014439966153421642,0.08273719809785791,0.8615459049360912,-0.14825414546857388,0.17713407777541715,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.01415843396812083,0.016282447550417592,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0063853358079093425,0.08449451505510716,0.9398012445942124,-0.15976435719429896,0.17253502881011765,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.08329166235768647,-0.111916389229897,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014225831008675999,0.07187147064872175,0.8432051484603297,-0.12710195548863887,0.15555361750599087,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.10067169314698664,0.11858687892123793,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04576237798352247,0.0750598802030384,0.5424491675200562,-0.19335984090030098,0.10183508493325602,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1006846092474461,-0.176034347224946,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0016258860541052411,0.09359928229461599,0.9861502380894502,-0.1824273866149529,0.18567915872316337,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0024156110059073387,0.005873380142711375,0.9990098172080826,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03856942614411068,0.08463515417568208,0.6488629718106169,-0.12785681908982985,0.20499567137805122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03301388880378731,0.12944145691078868,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011708117324082369,0.08459077233406158,0.8899925452560941,-0.15463085562531628,0.178047090273481,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11802232315671697,0.19620883470151812,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04429966187325365,0.11098371635043136,0.6900095687375166,-0.17393829579585493,0.2625376195423622,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.03420304894469407,0.035473223668509746,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.240300884581995,0.15225266928087794,0.11535048177688859,-0.05908818514976377,0.5396899543137538,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.09482547507469895,0.2634949692661065,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038765954574060804,0.09667919925138042,0.688669887985631,-0.15134365508332087,0.2288755642314425,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11463096094305093,0.19387991485347672,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0316864002200894,0.0791219797278456,0.6890375893580453,-0.12389875975076359,0.18727156019094238,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11810109273097448,0.18185667931445645,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037616409255314065,0.10453164809991934,0.7191596424172817,-0.2431670444591395,0.16793422594851137,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10130430001896303,-0.1902102637464522,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06330646397696085,0.10984654007543343,0.5647511211349019,-0.15269535459060873,0.27930828254453044,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06647238549929033,0.13676082272742263,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01796224961080456,0.11251154177148166,0.8732454304025165,-0.20328001815468033,0.23920451737628945,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04803548729968856,-0.07080058420304507,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0046455475030627025,0.11342156542608671,0.9673512809702988,-0.2183861873152689,0.2276772823213943,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.08047701258278321,-0.12252714316979318,0.9962636332708761,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006780247332956676,0.07643302766260615,0.929361695257367,-0.15707786219101974,0.14351736752510638,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07984301452498746,0.09925211394849325,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013328977881167308,0.094788155241389,0.8882477731599574,-0.19972004579049799,0.1730620900281634,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08212245254349688,0.0473293303001813,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03798795056404976,0.08991969872553332,0.6729308332519779,-0.13882980297124775,0.21480570409934724,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0527383116490391,0.06308786541884154,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0053382039830911915,0.0608542660598065,0.9301457942883202,-0.11432539331807365,0.12500180128425603,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.06792150019855571,-0.06926008203474748,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01315660304108146,0.14842813535629681,0.9294163327234176,-0.30502512381139285,0.27871191772922993,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06266867682840864,0.06561130657724262,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03266142470861984,0.0898915002769234,0.7165563636476928,-0.144100879504593,0.2094237289218327,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.05356655683072149,-0.05375944904910537,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0691746665089093,0.09053548801487186,0.44531765256232514,-0.10885397274259023,0.24720330576040883,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03255357823400227,0.09582627321962052,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035962874353545504,0.09913460980610803,0.7169852593469469,-0.23090079398579716,0.15897504527870615,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.012320530637226896,-0.02529805779560166,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03258306706361253,0.05229638235562826,0.5336379399996547,-0.07025234027432853,0.13541847440155358,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04707518766570305,0.06657027180245098,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010183032130557504,0.08706774597113374,0.9069589529390607,-0.1610266523568113,0.18139271661792628,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.21203489692085875,-0.245140607414293,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023916341491332996,0.1268587833818428,0.9849687524240547,-0.24706299494460243,0.251846263242869,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11833157010453954,0.13442000544871063,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039517511123536575,0.0806095782898171,0.6242592881934164,-0.19802787924808915,0.118992857001016,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.020809207772301035,-0.05887801778065112,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023892766297510873,0.07375884380471477,0.7461734029371608,-0.1689318761895376,0.12114634359451583,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03709408667359678,-0.008772363179942403,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016757008748738866,0.0841113893712469,0.8421969486220998,-0.18215332486354652,0.14863930736606878,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.013018276940982048,-0.08524217251834446,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04437830407519269,0.06892564078072747,0.5200666129233273,-0.17991342192549814,0.09115681377511275,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.024974640417107775,-0.024746284700646704,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0472872305505576,0.0858740269471587,0.5822003670679452,-0.21614959048987742,0.12157512938876221,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.012746119270544731,-0.16129069481992997,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0151322966164232,0.07350215731730929,0.8370013578264548,-0.15966665917600564,0.12940206594315923,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0313613676578291,-0.00901731298974202,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019109849422478675,0.07604281128262258,0.9799645137630474,-0.15144127979502514,0.1476193099105294,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.021106728972992667,-0.04862246375448109,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027259334409322024,0.0717453310790941,0.7042036742281264,-0.16833908053673366,0.11382041171808963,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03552393390393304,-0.010281849219528627,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01607000400024906,0.05053764900719059,0.750678860719046,-0.11544704477173212,0.083307036771234,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.016620300314139174,-0.0328533707409012,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0691118138366017,0.07270632668420078,0.3424476598195124,-0.2120812580664382,0.07385763039323481,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06971133630176095,-0.01037598251587987,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020463722200149248,0.05464959785322009,0.7082816070608446,-0.12792648354134034,0.08699903914104186,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008501919075217973,-0.03857131653643536,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029990541708869684,0.07627961767480143,0.6944234166175833,-0.12000540833271857,0.17998649175045794,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.047977711729786356,0.07508605004969932,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08471325266055865,0.11936228902125559,0.47832766505292934,-0.3194268037589711,0.15000029843785379,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03110924068690888,-0.1664770281463176,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02247735858354335,0.04733143680360414,0.6351435686718716,-0.07059499870667008,0.11554971587375676,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0053265639058155245,0.00040653276963929265,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012685778050282037,0.053981026604034886,0.9812637571238885,-0.1048795075748916,0.10741666318494801,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04254523449976809,0.032029625912471556,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035900274240262604,0.06516978384815204,0.5820531998169416,-0.16404988930496558,0.09224934082444039,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03155453877919928,-0.03039745836793113,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02744072305106876,0.051857829286506424,0.5970166647789261,-0.12941376130206678,0.07453231519992924,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.013983880165355962,-0.04132691706152281,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011365426699639254,0.08067018544152647,0.8880354293186526,-0.16999497249677428,0.1472641190974958,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.016408024689353717,-0.007210250797700164,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031000133239421083,0.06642956970692511,0.6410166158193502,-0.16162698642481338,0.09962671994597122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05008752943398095,0.013538391202427018,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030153766124821207,0.07209683621276515,0.6760144398097451,-0.11161717836037796,0.17192471061002038,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.030169673910327915,0.06792516225452595,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00428387548899763,0.060722825746014245,0.9437955910852531,-0.11512125807910177,0.12368900905709702,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.06885382001474316,-0.11306247144826376,0.9928239334792922,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1277275849981476,0.09794598836449189,0.19736442642429042,-0.06833261241294164,0.32378778240923684,54,7,61,1,log_other_mut_burden,False,58,0.038612770297665036,0.18586831256414588,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1329429599818308,0.12612760647140134,0.29623794181532104,-0.11952887512536303,0.38541479508902465,54,7,61,1,log_other_mut_burden,False,58,-0.09777430270469711,0.11332240281223707,0.8833721946393759,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04385396331413623,0.08620433456592137,0.6128775034890128,-0.1287027603955741,0.21641068702384653,54,7,61,1,log_other_mut_burden,False,58,-0.041509506699537596,0.0531128018852726,0.9552369178668337,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017506902076000835,0.10708054692653714,0.8706987811023008,-0.19683810091868292,0.2318519050706846,54,7,61,1,log_other_mut_burden,False,58,-0.01604302567593418,0.15363727301901595,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05284278951884384,0.10578187680170931,0.6192854094559641,-0.158902642780835,0.26458822181852265,54,7,61,1,log_other_mut_burden,False,58,0.02950533814121752,0.16312435016097296,0.9576211468940484,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01780448536401381,0.0667246262775935,0.7905424273053865,-0.11575936567890173,0.15136833640692934,54,7,61,1,log_other_mut_burden,False,58,-0.033995778261221944,0.04097355107877482,0.972929334907502,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02960631411343408,0.10792171251354606,0.7848046953466389,-0.24563509297069488,0.1864224647438267,54,7,61,1,log_other_mut_burden,False,58,-0.06646262707579995,0.03612647920584349,0.9721878388985049,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06985727044257953,0.08831778199982286,0.43218046015681555,-0.10692997794739326,0.2466445188325523,54,7,61,1,log_other_mut_burden,False,58,0.040242557970548376,0.12992700223359083,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07785442494045637,0.07966223665012159,0.3324762579235555,-0.08160686698820742,0.23731571686912017,54,7,61,1,log_other_mut_burden,False,58,-0.023138155312741552,0.09412852204223353,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010120007059102635,0.09759934528601952,0.9177736348731667,-0.18524630884105053,0.20548632295925578,54,7,61,1,log_other_mut_burden,False,58,-0.061180848829625475,0.09507895554313316,0.9901412236863718,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07317585142749329,0.0604886526680637,0.23128445644136364,-0.04790534221055817,0.19425704506554475,54,7,61,1,log_other_mut_burden,False,58,0.050317742665108196,0.18069311265635046,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03717600226985267,0.10149236674760971,0.715478815097085,-0.24033504729582356,0.1659830427561182,54,7,61,1,log_other_mut_burden,False,58,-0.06290614346393598,0.04016075941593162,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10039605800714067,0.08741090262245993,0.25545520676436956,-0.074575874077154,0.27536799009143537,54,7,61,1,log_other_mut_burden,False,58,0.0006390228561503131,0.1661784840343193,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11715218079959162,0.0898214207319036,0.1972907867235607,-0.06264492753022517,0.29694928912940843,54,7,61,1,log_other_mut_burden,False,58,-0.035427248512324275,0.12966366658805847,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01445731292135044,0.1216495493372547,0.9058096531031338,-0.25796534276812166,0.22905071692542076,54,7,61,1,log_other_mut_burden,False,58,-0.14677095504252988,-0.14750474138366473,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14552488896502191,0.15884803392104294,0.36339407260778056,-0.17244399785682518,0.463493775786869,54,7,61,1,log_other_mut_burden,False,58,-0.10792583792987667,-0.04400390746287575,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06511462719188899,0.05863835328336072,0.2713901108899815,-0.05226278981689936,0.18249204420067733,54,7,61,1,log_other_mut_burden,False,58,-0.07986314374722189,0.019826589969810432,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04718480977763156,0.08766243631763383,0.5924602116268072,-0.12829062170214436,0.2226602412574075,54,7,61,1,log_other_mut_burden,False,58,0.061362713825196084,0.19295975805333418,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05558249695711344,0.07251333593554306,0.44647914241831477,-0.08956871541876012,0.200733709332987,54,7,61,1,log_other_mut_burden,False,58,0.011596914773846334,0.13410738686414123,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03531357622083004,0.07266541353271531,0.6288159178940513,-0.11014205254025003,0.1807692049819101,54,7,61,1,log_other_mut_burden,False,58,0.026210530166706162,0.13451255150933608,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17690890277435395,0.16014299468555893,0.2738542571187548,-0.1436521296511069,0.4974699351998148,54,7,61,1,log_other_mut_burden,False,58,-0.13600617774999663,0.15084953325337552,0.870270919138952,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011682637955959472,0.07808413018220142,0.8815866102225097,-0.1446197306640258,0.16798500657594476,54,7,61,1,log_other_mut_burden,False,58,-0.0035028043278469635,0.09935017340170771,0.9867875051416815,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0300954423070466,0.06551392310150861,0.6476822423225373,-0.10104492302018965,0.16123580763428286,54,7,61,1,log_other_mut_burden,False,58,-0.09763668023198736,-0.013387869263085701,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08157354596531194,0.070819220811886,0.25410616640106276,-0.2233336184780063,0.060186526547382435,54,7,61,1,log_other_mut_burden,False,58,-0.04737232999906851,-0.007409328478365261,0.8638521408529491,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01195628418071665,0.07468024097087227,0.8733588187972523,-0.13753245989085774,0.16144502825229104,54,7,61,1,log_other_mut_burden,False,58,-0.03444796424610952,0.07443136250011327,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07068366041443966,0.07286969818790058,0.3360739535606668,-0.07518088851266733,0.21654820934154664,54,7,61,1,log_other_mut_burden,False,58,0.10838419778656104,0.23803642229791147,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08282200869557801,0.0690132745097725,0.23498414227769415,-0.055323069528748325,0.22096708691990435,54,7,61,1,log_other_mut_burden,False,58,-0.118506282832496,0.018325058793577504,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055343130339194385,0.06569011036023638,0.40297563175400186,-0.07614991210432084,0.18683617278270961,54,7,61,1,log_other_mut_burden,False,58,0.2200816903536499,0.31390803808954254,0.923447045283853,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09665608829505261,0.09562822141146896,0.31633493702676396,-0.09476459448199658,0.2880767710721018,54,7,61,1,log_other_mut_burden,False,58,-0.06965100930179734,0.08567347046954835,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02541273159381657,0.04569007049925396,0.5802149807143504,-0.11687134456400165,0.0660458813763685,54,7,61,1,log_other_mut_burden,False,58,0.11984368642967497,0.1708173392249502,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1083394907511006,0.06966510748691726,0.12535124481819748,-0.031110372940318834,0.24778935444252004,54,7,61,1,log_other_mut_burden,False,58,-0.05867043996874139,0.09021387720718203,0.7261583573371491,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03934270833174483,0.12254062367939736,0.7493201139894645,-0.2846344172688562,0.20594900060536653,54,7,61,1,log_other_mut_burden,False,58,-0.14240024019802974,-0.044575515547419016,0.964192424193284,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.079062978574785,0.07221507447240373,0.2781184075574184,-0.22361715576504584,0.06549119861547584,54,7,61,1,log_other_mut_burden,False,58,-0.06212457162079632,-0.020576678994931524,0.8739920503526474,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1277269993430528,0.08922226050217091,0.1576366786907355,-0.050870759479103606,0.3063247581652092,54,7,61,1,log_other_mut_burden,False,58,-0.02452102326461716,0.14765272802082227,0.780274991675152,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057336073742314704,0.14853062934067057,0.700892852937069,-0.23998028394000093,0.3546524314246303,54,7,61,1,log_other_mut_burden,False,58,-0.13068074096176982,0.0010720938959506235,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07784286217500411,0.11119160677895865,0.48667693578046256,-0.14473132120463933,0.30041704555464754,54,7,61,1,log_other_mut_burden,False,58,0.29266739573909345,0.3390715224502311,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01607783934534628,0.09613079647980412,0.8677554089554702,-0.1763488567330849,0.20850453542377748,54,7,61,1,log_other_mut_burden,False,58,-0.005901677738079895,0.05880516550225882,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10194683862419088,0.105374618130532,0.3373258993878515,-0.10898337687282258,0.31287705412120437,54,7,61,1,log_other_mut_burden,False,58,0.46603573364905126,0.48785216129892817,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07099314316216479,0.05998314144417208,0.24141890743527705,-0.04907615982059116,0.19106244614492074,54,7,61,1,log_other_mut_burden,False,58,-0.07410662284569873,0.03441958587630371,0.8487082760058587,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08487466131657846,0.05825835226521334,0.1505459788532222,-0.03174210101019127,0.2014914236433482,54,7,61,1,log_other_mut_burden,False,58,0.0059192666794947125,0.132633728164304,0.7680900043895489,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030081842532103553,0.07727977936884335,0.6985101806177048,-0.12461044300139645,0.18477412806560356,54,7,61,1,log_other_mut_burden,False,58,-0.07190145270394699,0.03827042428004652,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0861941250195627,0.05146257862193664,0.09934020121065472,-0.016819418387166704,0.1892076684262921,54,7,61,1,log_other_mut_burden,False,58,-0.022279140140474833,0.08721498067889764,0.6779844217208436,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08576365295490915,0.07307837029934722,0.24535826363135013,-0.060518598586134065,0.23204590449595236,54,7,61,1,log_other_mut_burden,False,58,-0.021117988639277392,0.09886634403425203,0.8538596653685477,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07759415800956078,0.07718954232563542,0.3189559401300885,-0.07691749845683234,0.2321058144759539,54,7,61,1,log_other_mut_burden,False,58,-0.020440495351519965,0.10248530673204238,0.9027017389660956,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07219733878313253,0.07028418527473662,0.3085817972071527,-0.06849174374021089,0.21288642130647595,54,7,61,1,log_other_mut_burden,False,58,0.0371010116872385,0.1330284824172728,0.8969323713769235,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07986580712476923,0.06801960078496183,0.24513011695331405,-0.056290217031067846,0.2160218312806063,54,7,61,1,log_other_mut_burden,False,58,-0.04232153033272888,0.06931609543523888,0.8535607195906675,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06778840741137368,0.060854820698934706,0.26990142294566727,-0.05402575117620731,0.18960256599895467,54,7,61,1,log_other_mut_burden,False,58,-0.056917453190856476,0.0818913679258004,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08390840916592847,0.046861627298440095,0.07858368587087854,-0.00989532953285674,0.17771214786471368,54,7,61,1,log_other_mut_burden,False,58,-0.035167070608583144,0.05681907629957683,0.6337247675321748,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04100554003896161,0.05657876032645449,0.471518278691779,-0.07224915373776514,0.15426023381568835,54,7,61,1,log_other_mut_burden,False,58,0.02797267836248005,0.04860911871589306,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09877309998742541,0.09386044786952556,0.2970082174200147,-0.08910899958270634,0.28665519955755714,54,7,61,1,log_other_mut_burden,False,58,-0.03604621738257807,0.11469925604261004,0.8843360296870468,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047553458699972746,0.060798154923007434,0.4373062408377004,-0.07414727101318197,0.16925418841312745,54,7,61,1,log_other_mut_burden,False,58,-0.2775415376673824,-0.2264220999824211,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07235066738973908,0.05722427500485465,0.21116703919869212,-0.042196164405013656,0.18689749918449183,54,7,61,1,log_other_mut_burden,False,58,0.2753661884725152,0.3596181296360905,0.826142906436283,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11485018767773207,0.14709612410743714,0.4381051913396341,-0.17959469579812232,0.4092950711535865,54,7,61,1,log_other_mut_burden,False,58,-0.1729340530385872,0.03979425508390675,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08148084188392932,0.0843766680975937,0.33821383115552506,-0.08741740990094352,0.2503790936688022,54,7,61,1,log_other_mut_burden,False,58,0.24029795907516915,0.3459192649461353,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11488724876061936,0.09958064418004216,0.25335091628187717,-0.08444506777701653,0.31421956529825523,54,7,61,1,log_other_mut_burden,False,58,0.051701792379801916,0.21039542568505948,0.8628310878918259,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09761827099567116,0.1071691995999214,0.36612887099995395,-0.1169041896053421,0.31214073159668443,54,7,61,1,log_other_mut_burden,False,58,-0.046080495342549675,0.17594347712040145,0.914684777397777,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11676432343536243,0.10767762220158744,0.2826798588607468,-0.09877585557674036,0.33230450244746523,54,7,61,1,log_other_mut_burden,False,58,-0.09964410304207642,0.03892697811629973,0.877125252431494,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0540880317133574,0.07651985403010486,0.4824901771318011,-0.20725916140965958,0.09908309798294476,54,7,61,1,log_other_mut_burden,False,58,0.11531465524892336,0.20668352131538922,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059578785172293154,0.09391855250847375,0.5283359417501376,-0.12841962346953115,0.24757719381411744,54,7,61,1,log_other_mut_burden,False,58,-0.08157295748020588,0.040618935982626524,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09848453366577764,0.08565640584580797,0.25496058510941944,-0.07297539154481633,0.26994445887637164,54,7,61,1,log_other_mut_burden,False,58,-0.05095966696856183,0.12736751666570034,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07493399817361279,0.05441785545813187,0.17380053358710154,-0.033995174546618004,0.18386317089384357,54,7,61,1,log_other_mut_burden,False,58,0.014616644911245265,0.07718036876214707,0.7883592203510926,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008920607056973177,0.06285811892958672,0.8876377404710861,-0.11690358862486117,0.1347448027388075,54,7,61,1,log_other_mut_burden,False,58,-0.11904228192165774,-0.04611745482168128,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03125106358632744,0.07605455295930066,0.6826576950513428,-0.12098866482115446,0.18349079199380935,54,7,61,1,log_other_mut_burden,False,58,-0.09130147363993829,0.008255647262380943,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01857343677273231,0.10864145763153464,0.8648495713511862,-0.23604294201679907,0.19889606847133443,54,7,61,1,log_other_mut_burden,False,58,-0.00024059104808759113,0.11791414321025905,0.9858092902621649,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06120781069845486,0.11889953362361613,0.6086588901670111,-0.1767954646126519,0.2992110860095616,54,7,61,1,log_other_mut_burden,False,58,-0.024572161054809468,0.06919635903122925,0.9540944451314641,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019192283610783067,0.06228570788058294,0.759085034891899,-0.1054861068661425,0.14387067408770865,54,7,61,1,log_other_mut_burden,False,58,0.00031809680962831575,0.08681426285938819,0.9671937410869814,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05186516978611819,0.11031134756967194,0.6399962021138852,-0.1689469833437162,0.2726773229159526,54,7,61,1,log_other_mut_burden,False,58,-0.047246031663398365,0.09312620197402185,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11171199012671551,0.07382424075736894,0.13565534602326018,-0.03606328335105721,0.25948726360448826,54,7,61,1,log_other_mut_burden,False,58,0.15076850022568497,0.2689566715418164,0.7473242853882033,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053771886066735046,0.08192581298632702,0.5141955637260516,-0.11022044619080854,0.21776421832427864,54,7,61,1,log_other_mut_burden,False,58,-0.03275603304711416,0.0792824330931696,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11927663560928882,0.08478828434682337,0.16483492546562892,-0.05044555561842533,0.28899882683700295,54,7,61,1,log_other_mut_burden,False,58,0.009390180285615514,0.14405092654024648,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03159303836237361,0.07020310752078386,0.6543711462366478,-0.10893374940330734,0.17211982612805454,54,7,61,1,log_other_mut_burden,False,58,0.07589755347334524,0.14572473341545406,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09292988191913942,0.06789918602951993,0.17638824282886767,-0.042985105915380545,0.2288448697536594,54,7,61,1,log_other_mut_burden,False,58,0.07497854843459512,0.18699652397349356,0.7917994815735138,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04042989904588025,0.07809652174502402,0.6066426175484422,-0.11589727398206291,0.19675707207382342,54,7,61,1,log_other_mut_burden,False,58,-0.006777260222511805,0.054826199083496695,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08528938265142305,0.1316113368118922,0.5195164930516841,-0.178159331356669,0.3487380966595151,54,7,61,1,log_other_mut_burden,False,58,-0.10408456877675329,0.10199013033648403,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026459460983733734,0.057251251983127645,0.6456928270999829,-0.08814137110009747,0.14106029306756493,54,7,61,1,log_other_mut_burden,False,58,-0.002386759604981062,0.04870881042683889,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018354132873831485,0.07161679685040506,0.7986395407924937,-0.12500246154010178,0.16171072728776473,54,7,61,1,log_other_mut_burden,False,58,-0.0523570861863179,0.06823509047834951,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05300543205233025,0.07445064237146148,0.4793473251971466,-0.09602372048846833,0.2020345845931288,54,7,61,1,log_other_mut_burden,False,58,-0.022794253783084327,0.05189064444899675,0.9384017168502401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03357932178953469,0.06016058713918129,0.5788824659892602,-0.08684517734340752,0.1540038209224769,54,7,61,1,log_other_mut_burden,False,58,0.0328679027441638,0.13590209126268593,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06624840309297754,0.06844567440319325,0.3371143794117173,-0.0707605000740064,0.20325730625996147,54,7,61,1,log_other_mut_burden,False,58,-0.07206675065089437,0.026211353595769593,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11885889780979482,0.06408432709935726,0.06872083348294787,-0.009419820204670928,0.24713761582426058,54,7,61,1,log_other_mut_burden,False,58,-0.007709412753199881,0.13771916255406438,0.6034358143668586,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06849639902459449,0.06388425443914406,0.2880734223825675,-0.05938183004782306,0.19637462809701206,54,7,61,1,log_other_mut_burden,False,58,0.002017554727816791,0.13628267634469793,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05355111761915724,0.05733034886025713,0.35413536979285964,-0.06120804406656535,0.16831027930487982,54,7,61,1,log_other_mut_burden,False,58,-0.10225116738453911,-0.05917004804322199,0.9094475823584263,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07710772936759401,0.07201638584197542,0.28874109680852394,-0.06704872931723761,0.22126418805242565,54,7,61,1,log_other_mut_burden,False,58,-0.010359255807130251,0.12109826089983196,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04845381386937048,0.044151704710541965,0.27698477351750933,-0.03992542540453893,0.13683305314327987,54,7,61,1,log_other_mut_burden,False,58,-0.053291108218641574,-0.0007281377679234924,0.8725380346331878,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0351679066668126,0.0807640329871087,0.6648591433525335,-0.12649887025356543,0.19683468358719064,54,7,61,1,log_other_mut_burden,False,58,-0.03988130781594247,0.08147069165491974,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07154297073242322,0.06742172593537163,0.2930311943666655,-0.06341627688365847,0.2065022183485049,54,7,61,1,log_other_mut_burden,False,58,0.10519177125466392,0.22507246895744545,0.8803348634474737,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16458253193637606,0.14165783237182153,0.2500627760824977,-0.11897642788841406,0.4481414917611662,54,7,61,1,log_other_mut_burden,False,58,-0.11410470957417544,0.127173741008495,0.8577585765822857,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038951255121664294,0.08126340763048034,0.6335127051407156,-0.20161763899681817,0.12371512875348957,54,7,61,1,log_other_mut_burden,False,58,0.04003428866295896,0.12617683526049922,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13160197590296563,0.07790969415756495,0.0965582474018374,-0.024351221076640034,0.28755517288257126,54,7,61,1,log_other_mut_burden,False,58,0.016164006915609937,0.2343098857632056,0.673446463693037,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05238336511774952,0.0847531108942707,0.538948650586222,-0.11726841879501221,0.22203514903051125,54,7,61,1,log_other_mut_burden,False,58,-0.046264415216009824,0.009001539610933052,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08352847071167319,0.1295149768206174,0.5215136081488494,-0.1757239228488216,0.342780864272168,54,7,61,1,log_other_mut_burden,False,58,-0.10086351840552871,0.07914429698862001,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09692087217029842,0.07172812135205911,0.18187055121637685,-0.0466585624450095,0.24050030678560635,54,7,61,1,log_other_mut_burden,False,58,-0.021647415107500012,0.11300095481152128,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08984651314875285,0.08326182359733877,0.28501739574534385,-0.07682013490785654,0.2565131612053622,54,7,61,1,log_other_mut_burden,False,58,-0.020365272128954174,0.15303492939094013,0.8771632762317894,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12620146541426597,0.10160169127814625,0.21919151875783,-0.07717641643592588,0.3295793472644578,54,7,61,1,log_other_mut_burden,False,58,0.07991799970794207,0.252049122532776,0.8337844604918982,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04865089998518483,0.07417921168276868,0.5145099985565897,-0.09983492500032379,0.19713672497069343,54,7,61,1,log_other_mut_burden,False,58,-0.002753586703479192,0.15035260148684662,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020192702369766946,0.04682122123203193,0.6678690615328193,-0.0735301547994235,0.11391555953895739,54,7,61,1,log_other_mut_burden,False,58,0.2169592741558324,0.23920717347735346,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09543672440137539,0.07138202090850575,0.18644783051387515,-0.04744991490480134,0.23832336370755214,54,7,61,1,log_other_mut_burden,False,58,0.026432225728676893,0.14116834449144902,0.8085168201280608,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12558245576706215,0.10327009485375967,0.22888887609376804,-0.08113509869104552,0.3323000102251698,54,7,61,1,log_other_mut_burden,False,58,0.01604550482651289,0.21873172566488888,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05420145023047367,0.0662719850404673,0.41678234430241257,-0.07845634093404122,0.18685924139498858,54,7,61,1,log_other_mut_burden,False,58,0.007773139929919198,0.1488221818024715,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05995054562905808,0.06775858563409441,0.37993569075288447,-0.07568299993566088,0.19558409119377704,54,7,61,1,log_other_mut_burden,False,58,0.07205864028938368,0.13833267000155922,0.9192104581519039,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11664318012403908,0.06922589085640085,0.09736944598377797,-0.021927495958748308,0.25521385620682646,54,7,61,1,log_other_mut_burden,False,58,0.057540302835348514,0.189248125396736,0.6768114380203412,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03929875062424969,0.06310490020233721,0.5358879811205122,-0.08701943144600892,0.16561693269450828,54,7,61,1,log_other_mut_burden,False,58,-0.037792481502171675,0.04175965347796584,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05249600558119101,0.06420742280611055,0.41693157964293903,-0.07602911526170604,0.18102112642408807,54,7,61,1,log_other_mut_burden,False,58,-0.013759366115716497,0.05730338913437933,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07125354161288448,0.08140936513398887,0.38504816819908116,-0.09170500794898458,0.23421209117475356,54,7,61,1,log_other_mut_burden,False,58,-0.14900765713650493,-0.07598586583830837,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06580170075483228,0.061106086884844465,0.28600885332541187,-0.056515421750258754,0.18811882325992332,54,7,61,1,log_other_mut_burden,False,58,0.0006443629967478015,0.10357817184814515,0.8775950049080478,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08346266569841215,0.06845829273968133,0.22771278140399304,-0.05357149581334081,0.22049682721016511,54,7,61,1,log_other_mut_burden,False,58,-0.06549396203593313,0.012392799546706579,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07375107790277538,0.06634307021717252,0.27087032737835487,-0.059049005702813906,0.20655116150836467,54,7,61,1,log_other_mut_burden,False,58,0.023496334198277482,0.0912042911755996,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07066598893037758,0.06879293585573389,0.3085784607319296,-0.06703803355772663,0.20837001141848177,54,7,61,1,log_other_mut_burden,False,58,-0.10422552940461101,-0.02621984745796436,0.8969323713769235,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02694155564501114,0.04121883265473426,0.5159381139357483,-0.055566902356026994,0.10945001364604928,54,7,61,1,log_other_mut_burden,False,58,-0.07718076679035456,-0.03885878115126127,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07536200204799644,0.04693434114646,0.11377357538155401,-0.018587289231709686,0.16931129332770256,54,7,61,1,log_other_mut_burden,False,58,-0.08404789597598183,-0.01862797777822873,0.7095033877612622,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11065195363075134,0.07029857347427984,0.1209204425975696,-0.03006593000318311,0.25136983726468576,54,7,61,1,log_other_mut_burden,False,58,0.02677384833038825,0.1578985590326694,0.7228579124835106,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04903307320911243,0.0708439516696428,0.491618715034422,-0.09277650349395161,0.19084264991217648,54,7,61,1,log_other_mut_burden,False,58,-0.0221915340277032,0.09341440623001795,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09208855558677129,0.12996305047026172,0.4814266180658563,-0.16806075483240127,0.35223786600594387,54,7,61,1,log_other_mut_burden,False,58,0.026095582419863983,0.23181653539526456,0.9396519533333579,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06780493892920739,0.08046832054889769,0.4028974080807559,-0.22887978309173923,0.09326990523332446,54,7,61,1,log_other_mut_burden,False,58,0.04100481421619499,0.08070240380633753,0.923447045283853,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0710392931090614,0.04902576783761253,0.15271751511152765,-0.02709644354513277,0.16917502976325557,54,7,61,1,log_other_mut_burden,False,58,0.0173751569285507,0.11108129107311138,0.7692078902000675,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04076657371883508,0.08125976587323683,0.617790213894846,-0.12189252038717144,0.2034256678248416,54,7,61,1,log_other_mut_burden,False,58,0.018558867260391906,0.1323290685717166,0.9570684461157861,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07924801278525606,0.07294984771239287,0.28182489579863157,-0.06677697284637307,0.2252729984168852,54,7,61,1,log_other_mut_burden,False,58,0.024862183093623532,0.15122196658572676,0.8770089248428307,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08559283728920515,0.07286413757225511,0.24491876620014977,-0.060260580856341686,0.231446255434752,54,7,61,1,log_other_mut_burden,False,58,-0.024034055601079688,0.1409320282999132,0.8534526629046483,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1038979209576137,0.07109879016819336,0.1493251001406431,-0.03842177042363233,0.24621761233885975,54,7,61,1,log_other_mut_burden,False,58,-0.06967465507340154,0.08643521652821937,0.7662201971017615,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08442489087313533,0.0833372998012432,0.31524362647928533,-0.08239283922046646,0.2512426209667371,54,7,61,1,log_other_mut_burden,False,58,-0.03241432966394364,0.12459813732414064,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025859997384115943,0.07441243166433634,0.7294567772411225,-0.12309266811614865,0.17481266288438052,54,7,61,1,log_other_mut_burden,False,58,-0.02693379522763659,0.05265241871650123,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03639369794403025,0.10451062611656904,0.7289285199842247,-0.1728070496324717,0.2455944455205322,54,7,61,1,log_other_mut_burden,False,58,0.01795790733571334,0.17085143434522745,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04988169795570766,0.10854542870368791,0.6475594938252855,-0.2671589804159199,0.16739558450450456,54,7,61,1,log_other_mut_burden,False,58,0.14492700298924094,0.20465440877365287,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013960243653393722,0.08726029631090636,0.8734496158483338,-0.18863070445062896,0.16071021714384154,54,7,61,1,log_other_mut_burden,False,58,-0.12303928284885558,-0.05108860032521902,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03748211619003665,0.10616490521739848,0.7253266913003757,-0.17503003078625162,0.24999426316632495,54,7,61,1,log_other_mut_burden,False,58,0.05913985576711827,0.17225417586040587,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012752168764431103,0.05014258845420846,0.8001493017809636,-0.08761912724465698,0.1131234647735192,54,7,61,1,log_other_mut_burden,False,58,0.04368819001243537,0.12707947798829158,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025861558142878105,0.06642898462781334,0.698471599637825,-0.10711050184063095,0.15883361812638716,54,7,61,1,log_other_mut_burden,False,58,0.006894745070830686,0.08867882802068397,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0639442123097749,0.07423550833790794,0.3925816572712765,-0.08465430267462484,0.21254272729417464,54,7,61,1,log_other_mut_burden,False,58,-0.10844212141305386,-0.018812834133107182,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024634537019364675,0.05035998362715467,0.6265669698704946,-0.12544099674710799,0.07617192270837864,54,7,61,1,log_other_mut_burden,False,58,-0.07770902558345633,-0.05347557841665635,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05152953121842508,0.0825081913075794,0.5347232389567758,-0.11362855790715656,0.2166876203440067,54,7,61,1,log_other_mut_burden,False,58,-0.043748490924990946,0.06359578535446016,0.9468590670943479,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025642394478638045,0.07796815712934987,0.7434287906233845,-0.1817126178110407,0.13042782885376458,54,7,61,1,log_other_mut_burden,False,58,0.016729431695502523,0.1410640491292742,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07641983503494588,0.06315035583647613,0.2311397234787517,-0.04998933637292151,0.20282900644281326,54,7,61,1,log_other_mut_burden,False,58,-0.11827647722942673,-0.04633472177329832,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05895012047713728,0.07011612958849342,0.40394092902191736,-0.08140256204074307,0.19930280299501762,54,7,61,1,log_other_mut_burden,False,58,0.038714093652950636,0.11700989713120988,0.9235345118679857,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07284467672391771,0.06162235683429253,0.24198410539796517,-0.050505872365522286,0.19619522581335772,54,7,61,1,log_other_mut_burden,False,58,0.04696396234622537,0.18958378229252415,0.8491564414671808,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06460732229562195,0.062098636565961964,0.30247249506081014,-0.059696604260044764,0.18891124885128868,54,7,61,1,log_other_mut_burden,False,58,-0.041936505471775604,0.06383988897558777,0.8904632102898862,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053014197857707654,0.05455099844403384,0.33517163334946554,-0.05618148950529443,0.16220988522070973,54,7,61,1,log_other_mut_burden,False,58,0.10227748517318486,0.21098072370259383,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.067218019005643,0.04361041776524593,0.12867533507852297,-0.020077716725927758,0.15451375473721377,54,7,61,1,log_other_mut_burden,False,58,-0.015243650136295535,0.0675650120854316,0.7302718857033121,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07703268506020958,0.06165996025769169,0.21656843438321305,-0.04639313545931224,0.20045850557973138,54,7,61,1,log_other_mut_burden,False,58,0.022273849164521128,0.14430658957086084,0.8295752524063543,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1100148715105687,0.11737667561510966,0.3525008929261214,-0.12494007229904004,0.34496981532017745,54,7,61,1,log_other_mut_burden,False,58,-0.014140715434113472,0.2093630059703707,0.9090812501778921,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004190997933976906,0.0961737193460467,0.9653909700871446,-0.18832161759628166,0.19670361346423546,54,7,61,1,log_other_mut_burden,False,58,-0.03474672309393812,0.06355024096168639,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07534293012421761,0.06401350655754627,0.24400917589340318,-0.052794025173468456,0.20347988542190368,54,7,61,1,log_other_mut_burden,False,58,0.01358037302716174,0.07967225512738665,0.8528284808184983,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06805152531150982,0.11803506132264839,0.5664834271993207,-0.16822132068019052,0.30432437130321016,54,7,61,1,log_other_mut_burden,False,58,-0.09510999471436603,0.09157393336808663,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07879688888415348,0.09623134561204776,0.41623651488444,-0.11383107815030541,0.2714248559186124,54,7,61,1,log_other_mut_burden,False,58,0.006298697107206945,0.15648531940079433,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13279669915129286,0.09576954248985314,0.17086218314197926,-0.05890686849923624,0.324500266801822,54,7,61,1,log_other_mut_burden,False,58,-0.07252089288346822,0.08728151138944742,0.7844441930486012,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08061261325704934,0.08819088457460424,0.36446462257329737,-0.09592062233817032,0.257145848852269,54,7,61,1,log_other_mut_burden,False,58,0.09862892024071114,0.2732037520390696,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09374894358424042,0.12080042457342154,0.44086401045187373,-0.14805937837654526,0.3355572655450261,54,7,61,1,log_other_mut_burden,False,58,-0.2863917966566272,-0.1256578275075809,0.9320838159679753,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016002376434938147,0.0876794160835865,0.8558188915096459,-0.15950704373922192,0.19151179660909823,54,7,61,1,log_other_mut_burden,False,58,-0.10921304476750812,-0.007882286981914765,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00470144504536028,0.0785113417948309,0.9524551810877102,-0.16185897061977586,0.15245608052905532,54,7,61,1,log_other_mut_burden,False,58,0.045685603821441816,0.1746586683545013,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012054617344925054,0.08126294954378775,0.8825882923599064,-0.1747200842599371,0.150610849570087,54,7,61,1,log_other_mut_burden,False,58,-0.027243466227042483,0.08880132338566413,0.9870366109823806,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048974085461466324,0.09403942571830975,0.6045009097814802,-0.13926627719785145,0.23721444812078407,54,7,61,1,log_other_mut_burden,False,58,-0.12169428174411745,0.01099334426566212,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021290259492318483,0.12387907846928789,0.8641433042091284,-0.22668065779945468,0.26926117678409167,54,7,61,1,log_other_mut_burden,False,58,0.7753120358289385,0.7887152312476191,0.9854445582989166,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033608092905978164,0.06926406394116841,0.9614671818666597,-0.13528627852339253,0.14200789710458817,54,7,61,1,log_other_mut_burden,False,58,0.09389825981235465,0.200395240771694,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02118465042664201,0.06439059215350276,0.7433390450381259,-0.10770712370148948,0.1500764245547735,54,7,61,1,log_other_mut_burden,False,58,0.09668170252353986,0.206751146792258,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04526191696968567,0.0901808529706195,0.6176367629918111,-0.13525467315673417,0.22577850709610553,54,7,61,1,log_other_mut_burden,False,58,-0.12633882631604834,-0.019207977169086447,0.9570174945596325,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025270326213428035,0.058752365537530576,0.6687052846606314,-0.09233531111793891,0.14287596354479498,54,7,61,1,log_other_mut_burden,False,58,0.023381934208181337,0.1271580570735574,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04161558621858907,0.09082925141852012,0.6485396258881763,-0.1401989144176861,0.22343008685486423,54,7,61,1,log_other_mut_burden,False,58,-0.17264688621396285,-0.05728746458894603,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0235505657640319,0.10121007447831465,0.816821362400216,-0.17904340989085205,0.22614454141891582,54,7,61,1,log_other_mut_burden,False,58,-0.1276457462838004,-0.024479294558014737,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09872508528045788,0.06683712813590942,0.1450585477454592,-0.035063962699247456,0.23251413326016324,54,7,61,1,log_other_mut_burden,False,58,0.0017336720060986894,0.14062722631832197,0.7643196110722902,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08468054153133453,0.050331175996648075,0.09785498637638324,-0.016068253458746934,0.185429336521416,54,7,61,1,log_other_mut_burden,False,58,-0.06534629686974158,0.00888281722120701,0.6772213442508546,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10143645592863194,0.09358466969092738,0.2828942285725534,-0.0858936136396541,0.288766525496918,54,7,61,1,log_other_mut_burden,False,58,0.02023810866551015,0.1693569386935861,0.877125252431494,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008597309041314309,0.07282549407530482,0.9064331138814684,-0.13717875574073862,0.15437337382336724,54,7,61,1,log_other_mut_burden,False,58,-0.07281355722275512,-0.023588643875405428,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02476820007329137,0.13656043209315263,0.8567081650663577,-0.2485872044900004,0.29812360463658316,54,7,61,1,log_other_mut_burden,False,58,-0.028604967608610428,0.14693235435137422,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03459365450947201,0.1006255286291527,0.7322503888077077,-0.1668302254988599,0.23601753451780394,54,7,61,1,log_other_mut_burden,False,58,-0.08556389006455972,0.010033230564561265,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009696987108827868,0.09806312459300776,0.9215704321637037,-0.1865976839389084,0.20599165815656412,54,7,61,1,log_other_mut_burden,False,58,-0.07366268663701184,0.022402171255285024,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01097177330821255,0.10286687171054128,0.9154268436303741,-0.21688218895052797,0.19493864233410285,54,7,61,1,log_other_mut_burden,False,58,-0.009243769540259376,0.08173706825505946,0.9895309118568834,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012370169590598537,0.06263026379798822,0.8441182023302023,-0.11299792449046288,0.13773826367165995,54,7,61,1,log_other_mut_burden,False,58,0.059271765337731916,0.13260744583622236,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13828604314816859,0.11046097877606124,0.21563169579967606,-0.082825629383669,0.35939771568000617,54,7,61,1,log_other_mut_burden,False,58,-0.24158606250685805,-0.10519552281893396,0.8295752524063543,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10539223779586808,0.14177519089172644,0.4602549423947737,-0.1784016406301291,0.3891861162218653,54,7,61,1,log_other_mut_burden,False,58,-0.1282512523864633,0.07574691549270214,0.9366557334939974,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07616254317662008,0.048374601438598244,0.12082702157752404,-0.020669742311579295,0.17299482866481947,54,7,61,1,log_other_mut_burden,False,58,-0.039445531460767964,0.04935907198263368,0.7228579124835106,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044971872422646095,0.06375163513768246,0.48337061660535485,-0.08264089027530065,0.17258463512059286,54,7,61,1,log_other_mut_burden,False,58,0.10278089012036146,0.1620547946201936,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043978782637642634,0.044197561974528295,0.3238452837152024,-0.04449224992336328,0.13244981519864854,54,7,61,1,log_other_mut_burden,False,58,-0.10043781068081777,-0.06819183387600894,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10897865195602871,0.08807886705512163,0.22096730454731187,-0.06733035621191205,0.28528766012396944,54,7,61,1,log_other_mut_burden,False,58,0.12367726687885805,0.22673379621913364,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01981564805742377,0.04843147365906735,0.6839379255126979,-0.07713047954885079,0.11676177566369832,54,7,61,1,log_other_mut_burden,False,58,-0.2087945468382897,-0.20957207368326863,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06713059483542756,0.05529129880997725,0.229620225299835,-0.04354696471360256,0.17780815438445768,54,7,61,1,log_other_mut_burden,False,58,0.06587294340781727,0.1444321761958936,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03175987847157472,0.04287059949631821,0.46178462004262566,-0.05405495009599338,0.11757470703914283,54,7,61,1,log_other_mut_burden,False,58,-0.058093059212777035,-0.025337736159670634,0.9370609591482926,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07088760064978349,0.07509406740254747,0.34909364050427083,-0.07942950702547659,0.22120470832504358,54,7,61,1,log_other_mut_burden,False,58,-0.05213950450257881,0.05501684362700251,0.9086977961712401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047582609365994406,0.0552474215575242,0.3926393951177216,-0.0630071203196442,0.158172339051633,54,7,61,1,log_other_mut_burden,False,58,-0.028160102611073556,0.0159906698762273,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042511273209197085,0.07577810642472707,0.5769607631890046,-0.1091750873365975,0.1941976337549917,54,7,61,1,log_other_mut_burden,False,58,-0.017516383866778645,0.061839524207551434,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05417112360644294,0.07040649567973191,0.44477498359610357,-0.08676278979307242,0.1951050370059583,54,7,61,1,log_other_mut_burden,False,58,0.05249734096634633,0.08461371288712809,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07123062430406162,0.05852163473140568,0.22846990954441532,-0.04591315513855421,0.18837440374667744,54,7,61,1,log_other_mut_burden,False,58,0.11316004759200238,0.18914223665391622,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04576226755093307,0.04274617122806046,0.2888029737667622,-0.039803490776541564,0.1313280258784077,54,7,61,1,log_other_mut_burden,False,58,-0.1724248272129833,-0.13653509376195244,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10977862215713718,0.06752502624616549,0.10942543104169235,-0.025387403497178218,0.2449446478114526,54,7,61,1,log_other_mut_burden,False,58,0.047833126112102255,0.1482096619436805,0.6985162532376802,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05931623385788294,0.061115732301980405,0.335799670329305,-0.06302019604733099,0.18165266376309686,54,7,61,1,log_other_mut_burden,False,58,-0.006748384771956867,0.05161637135669237,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08225334190426785,0.07469882801344074,0.27538763594740673,-0.06727260817539442,0.2317792919839301,54,7,61,1,log_other_mut_burden,False,58,-0.0038108905938864096,0.09449047903553731,0.8716406527156833,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040426272768965904,0.06606782040762678,0.543001477905904,-0.09182283848034803,0.17267538401827984,54,7,61,1,log_other_mut_burden,False,58,0.015483248182148064,0.048010176942355834,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0993753253641086,0.07075387788827212,0.1654965320400703,-0.042253949075922684,0.2410045998041399,54,7,61,1,log_other_mut_burden,False,58,-0.013029100711271105,0.10596532012204747,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08546036204531342,0.05694091257091212,0.13881626092385702,-0.028519258211066614,0.19943998230169346,54,7,61,1,log_other_mut_burden,False,58,-0.08144025640971021,0.02175250827320352,0.7542255162310588,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03250058403888535,0.09063822317968824,0.721215116088481,-0.21393270010952525,0.14893153203175458,54,7,61,1,log_other_mut_burden,False,58,0.36329556782354977,0.47907627052048013,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18821319956975263,0.0989897940013474,0.062229200472049745,-0.009936401834679615,0.38636280097418485,54,7,61,1,log_other_mut_burden,False,58,-0.16352672896862708,-0.08564162639985629,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00737918881646063,0.16736361185227033,0.964928663658662,-0.3398264438807953,0.3250680662478741,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11308336260379,-0.04055766985064389,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003432608914513191,0.20518352070832302,0.9866890719156602,-0.40413924908367893,0.4110044669127053,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1484956901019598,-0.059736461349169566,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1284908301413062,0.1419703892609042,0.36782688843232325,-0.15351590769047208,0.41049756797308445,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0466234156256688,0.1065215883766721,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05744284976082608,0.2982889383060193,0.847721319012073,-0.6499571822276872,0.5350714827060351,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.286659741730162,-0.22396970287038065,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15719274599061922,0.19471901955601917,0.42161030546553435,-0.22959266598624922,0.5439781579674876,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.17357108073012156,0.03004485843818109,0.9282753503874777,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1000272336368233,0.13817994988312543,0.4709894650087785,-0.17445026200972652,0.37450472928337314,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.07325300754365996,0.16946922008114568,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01513256816264033,0.2183924185583994,0.9449102467311248,-0.4186771427599927,0.4489422790852733,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.216263113362041,-0.12331370585335141,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10721639397240265,0.12871632564196028,0.4070444666237517,-0.14846277468349453,0.3628955626282998,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.009308329567424436,0.11260132153103734,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12031468326251801,0.151542896416528,0.42930076675401396,-0.18070666409370015,0.42133603061873615,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.133378485613195,0.026000720257170328,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005921288881362646,0.29871941752801257,0.9842285721990007,-0.5874481376775178,0.5992907154402431,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.2950432279441154,-0.17873354705287228,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14212304224936476,0.17161838886483438,0.40976120044235165,-0.19877580466987269,0.4830218891686022,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05261915916678836,0.14631710986793445,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03331994185802985,0.3206985835646025,0.9174789348757214,-0.6703482817051661,0.6037083979891064,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.2909747429937829,-0.22456546944913286,0.9900690300494123,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12470708860289448,0.1797850660436228,0.4896714088818491,-0.23241385929180014,0.4818280364975891,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09421683586917856,0.09486538950808887,0.9416210377190208,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15470119802493962,0.13887686555285444,0.26823634939497215,-0.12116063498651627,0.4305630310363955,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09670347985377323,0.10428231310550598,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14968813526708405,0.29724011745453055,0.6157641130191734,-0.440742843421302,0.74011911395547,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.28859190853243416,0.3787453404463478,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11127111773995374,0.14739740628377698,0.45225499680035486,-0.4040579582026075,0.1815157227227,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.25371687095429285,0.05584618953417995,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11807094044436671,0.14531908278164468,0.41862848247876894,-0.17058756569416011,0.40672944658289356,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12407550049934477,0.026400335979271616,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045917547795504096,0.18324833083210518,0.802707182057484,-0.31808275015473436,0.4099178457457426,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13858336765953233,-0.021805823807532786,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09056407720703728,0.1636848935407302,0.58142639580418,-0.23457585584571267,0.41570401025978726,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.15792215914318952,-0.00857490189826023,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052647894768275916,0.1590450912791772,0.7413866677268122,-0.26327564107110535,0.3685714306076572,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09451025280251926,0.017794424242059133,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24933160162014448,0.23146565582630252,0.28424443312759806,-0.21044648914574535,0.7091096923860343,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14829960064964817,0.17447864435141758,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0613805803661414,0.15418780354027664,0.6914964583324968,-0.36765571080853293,0.2448945500762501,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1783467432752545,-0.15519542822429316,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09887151049980256,0.16407853961445504,0.5482825238714857,-0.22705035212072103,0.42479337312032617,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09525948277930697,0.024486914559211433,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.24628063155806784,0.2895682558870112,0.39727406017611255,-0.8214723996968711,0.3289111365807355,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21766364926518628,-0.381807377733133,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030033278898010843,0.20119878573669675,0.8816695875848177,-0.3696233925861299,0.4296899503821516,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14035388325900436,-0.05353918751921094,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1879062181413354,0.09133763437830873,0.0425219390673132,0.0064752278736224245,0.3693372084090484,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.04115660645703404,0.2540853680556606,0.49492544327907945,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08614106406770519,0.16135477879856042,0.5947392452743223,-0.2343703822940247,0.40665251042943507,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06598610304074316,0.05120649511288593,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18100937462407682,0.10557343383667431,0.08983437855489859,-0.028699282462618464,0.39071803171077213,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.11021243596932373,0.3002003427531804,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16029544613313187,0.16132290647839795,0.3230373198507539,-0.16015268977996897,0.4807435820462327,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08221076348717765,0.1278491861090249,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0353945874046047,0.2024596156729047,0.8616071341490104,-0.36676656786042666,0.4375557426696361,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07485051707019225,-0.00347985492127703,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14702002200601957,0.13902180565215128,0.29306808474251933,-0.1291297167074387,0.42316976071947787,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06393962673426,0.13475630856360293,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07450409443770878,0.2144983016067434,0.7291370619203335,-0.35157043153552053,0.5005786204109381,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.26425367844578695,-0.10178258351907346,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13835704507634006,0.25148396539767465,0.5835558345071077,-0.637899048644883,0.36118495849220295,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.25653267173846855,-0.3103781055002548,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14593463165124243,0.14578777701646523,0.3194776360345202,-0.14365487800773968,0.43552414131022454,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10791566348576402,0.08332973950873859,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025837183514273165,0.29923804432272466,0.9313832622844549,-0.5685624314612927,0.6202367984898391,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.22697057022647119,-0.10698058438015949,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10381824539966258,0.10592221782079614,0.3296172971303173,-0.10658322822491939,0.31421971902424456,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07949686703666684,0.044746223661120535,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03378790198815244,0.16822491941305173,0.8412644367258243,-0.30037023473784646,0.3679460387141514,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09134908080961503,-0.015484470187499405,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048648655341849534,0.1081682689944779,0.6539603593681736,-0.16621432302178904,0.26351163370548814,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.021537500556118517,0.03060309778624305,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13857394128213654,0.10994768644497935,0.21076092099778934,-0.0798236312533519,0.356971513817625,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05481273814087988,0.10294960668915891,0.8252886794984905,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07368775253617635,0.11826847219101998,0.5348068410331639,-0.16123803871205927,0.30861354378441197,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.034353101183929674,0.0588973759027556,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11777010053343023,0.11984629451641723,0.32837228938504726,-0.12028984093570616,0.3558300420025666,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07294438375126576,0.06710181048029638,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04828956877565617,0.13605289736274395,0.7234615833311103,-0.22196279833815935,0.31854193588947166,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08985133918360075,-0.0019768918599740947,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0662013375177636,0.13602280565508607,0.6276461180541223,-0.2039912561154229,0.33639393115095007,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08673937585615742,0.009169338757333795,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12235679700698956,0.14534439005300942,0.40208416713658945,-0.1663519789172169,0.41106557293119605,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.036584899342967186,0.12739015725191585,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16523231148655196,0.1246987301350891,0.18847140657253753,-0.08246639723880142,0.4129310202119053,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.044919212481905745,0.141153074549729,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11756218968809587,0.10561609896720368,0.2685934676611167,-0.09223121643917326,0.327355595815365,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.023942718538748714,0.11604704535295036,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09469262088654727,0.1447793731924638,0.5147305453743308,-0.19289381845401005,0.3822790602271046,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11297009014152211,0.02508885765685055,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1184048690767596,0.08335597500614604,0.1588874732514451,-0.04717153535973817,0.28398127351325736,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.008425265628604994,0.11900976291002277,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1350193945110344,0.08760625477404221,0.12673670391995323,-0.03899966855629999,0.3090384575783688,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.00355237719053289,0.13002315919506757,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10677773681371078,0.07597711083498848,0.1633091779413933,-0.044141460407641525,0.2576969340350631,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05018806875731254,0.09534268478677461,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05434380608817378,0.07223438287133306,0.45379666335510327,-0.0891409218109697,0.19782853398731726,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13016251655063887,-0.05463467109416431,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06342271470950572,0.0926822570332084,0.4955231257901086,-0.12067920328121365,0.2475246327002251,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.11659566452477199,0.1689357032670302,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10963527877619522,0.20416542589651013,0.5925834326524664,-0.29591425894677964,0.5151848164991701,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12892728705867454,0.04256908089777132,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05719902846401917,0.18299776918749425,0.7553249506428206,-0.30630355955959054,0.42070161648762894,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05128952845406843,0.05255837695732044,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2035597715936298,0.17098414930621503,0.23693909162684745,-0.1360792363559376,0.5431987795431972,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.022963703822252234,0.21253162711278067,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10163495517171037,0.2853292466137511,0.7225135192012975,-0.4651365417893204,0.6684064521327412,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.20100556587114518,-0.01770816854315308,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2140960573090394,0.16083484540436102,0.18646350871806314,-0.10538260523663345,0.5335747198547123,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.03768636692757805,0.2660084557051586,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14697972388421315,0.247726743624062,0.5544428964833124,-0.6390584679575677,0.34509902018914146,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.278006675858959,-0.3034543645851871,0.9491210479105492,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07734348882151285,0.20081894070893072,0.7010321329144944,-0.321558667177254,0.47624564482027965,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09863966213177615,0.024188366313326846,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14449731471322422,0.1629152800194782,0.3774452131567495,-0.17911387562317907,0.46810850504962753,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14323185181707845,0.06654860670694066,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1634379148576204,0.08801853684645161,0.06656645838821185,-0.01140009589952437,0.33827592561476516,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.06188681393072382,0.21434022517596105,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02567270355208574,0.19269008932863677,0.8943031994937851,-0.35708248777320095,0.4084278948773724,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16700710112612985,-0.09425464171247303,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022910495925478582,0.12484795935582262,0.8548083586581957,-0.22508463831471154,0.2709056301656687,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16309116090485953,-0.09292095792068829,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05370683721817818,0.26483155335766595,0.8397470545023475,-0.4723485101406846,0.5797621845770409,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.24613092081828775,-0.10335514371290033,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08942499787452622,0.12441022580319704,0.474111131328111,-0.15770063243700594,0.3365506281860584,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05266408345213855,0.055113728082508376,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012490662820656875,0.16192189917187444,0.9386814894855922,-0.30914729849442935,0.33412862413574307,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11877723805410775,-0.06360563931266215,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11490922603279596,0.18102095650295233,0.5271620150299534,-0.24466666643567475,0.4744851185012667,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.15027339360798878,0.0044133340713737425,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1001161307156962,0.11456622241182045,0.38448869434596067,-0.12745559615118612,0.3276878575825785,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.07022320944942301,0.1823910306213624,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16782857529300949,0.11985811512459787,0.16484566368796855,-0.07025484636216828,0.40591199694818725,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0904496812535294,0.09736898348591198,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03402404641740362,0.12036752281792609,0.7780733103351494,-0.2050712510420864,0.2731193438768936,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.0016988969890385304,0.04781388040434373,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1899100744544331,0.0925364144496797,0.04301554935933143,0.006097854839776512,0.37372229406908963,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07527594251562993,0.15076814847603998,0.4970268279685195,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1788998747015776,0.15043409214601797,0.23744525717745849,-0.11991896918297762,0.4777187185861328,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0780341041947389,0.1421472764152218,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16518437652399937,0.09503167108454383,0.08555746513279701,-0.023584363864562807,0.35395311691256154,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09487592049962393,0.11002937556401068,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04032261566445618,0.3039636018187761,0.8947582823431984,-0.5634637387631579,0.6441089700920702,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.17829660140076536,-0.033583805705801904,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09364011580726468,0.06253753517370024,0.13776479979768008,-0.030583015355424195,0.21786324696995357,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.023475060923015285,0.07646751640951621,0.7510830912046598,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034508623003936936,0.28822161416331094,0.9049613846509037,-0.5380082067797213,0.6070254527875952,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1974085649678589,-0.08309621063939263,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1535346387406588,0.11728768020847676,0.19381569249529046,-0.07944292972021602,0.3865122072015337,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04759200495839872,0.13216288267030962,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10996401561695199,0.1486649597291591,0.46140007913244907,-0.1853406640516134,0.40526869528551734,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11943413315250538,0.03859898164191428,0.936984237335683,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11153714642305668,0.1627420129888729,0.4948578918328399,-0.2117298702421383,0.43480416308825165,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.15407951429012787,0.007616728710239681,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0898603788382793,0.08941579391619293,0.3175751092601726,-0.08775311144104952,0.2674738691176081,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1288215103308103,-0.002994832221506103,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11036112552682291,0.1557302372886481,0.4803416771397516,-0.19897786007553792,0.41970011112918376,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12295134075314043,0.0583903310819068,0.938972145291407,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14313428256654803,0.10191504836551175,0.16358984109475636,-0.05930744119817297,0.34557600633126906,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07347347374695315,0.08231904738599534,0.7815260814768127,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20649643738314227,0.11941713165471107,0.08716377344175613,-0.0307110247819761,0.4437038995482606,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.033444756737608036,0.19696373104463066,0.6570209000268399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11545982945119274,0.08053744305287065,0.15510874185641568,-0.044517907504319915,0.27543756640670536,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12068755444795914,0.01835194991524969,0.7738863562892694,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1365870944324853,0.14229362065933523,0.33965103375640826,-0.1460617028647272,0.4192358917296978,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06891968912757825,0.10573036110058684,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20928360099146884,0.1739457044589431,0.23203728113605712,-0.13623817245502837,0.5548053744379661,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05377375276635947,0.18411814515832253,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16362517268608812,0.20847099957834447,0.43456123983124006,-0.25047685823514854,0.5777272036073248,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.29486790729991363,-0.058298182352380525,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0733086466944016,0.16817164617482022,0.6639303048783682,-0.4073609626770356,0.26074366928823234,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14861409597896194,-0.14705959695349402,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09066822267555158,0.19451314266825612,0.6422370006136304,-0.29570824015484154,0.4770446855059447,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13569531302616294,0.014935321216818325,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11220878935568655,0.08361737016819377,0.1829569693460619,-0.053886844458978386,0.2783044231703515,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.020226605638099002,0.1369133708729751,0.801939493467167,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13539451090428006,0.19287178621643122,0.48447559344141167,-0.24772159896795048,0.5185106207765107,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14551603159560564,0.06162434528424039,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20407108904363871,0.149225918162029,0.17482698861102805,-0.09234786564055789,0.5004900437278353,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.051331995310464174,0.18355235265116157,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0520055674025804,0.13636714902072153,0.7038218959026423,-0.21887102202538,0.3228821568305408,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08612826623824218,0.024025192717835018,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18529253095028725,0.15829408469358275,0.24483247824734578,-0.12913922256465127,0.49972428446522577,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03748748978940268,0.17586370642074803,0.8534526629046483,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003169611604739952,0.22568038884717476,0.98882507129036,-0.45145598021107797,0.4451167570015981,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1605543892400155,-0.07902079774833899,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10929915157613454,0.060995209019193024,0.07646787944616087,-0.011860338148578883,0.23045864130084798,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.022010830392519054,0.14125476400624698,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09866675748415815,0.07676283509368062,0.20193322182981505,-0.053813184454332724,0.251146699422649,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.11331287464770205,0.20623882138606123,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16575733198932507,0.18196808428681677,0.3647471667534077,-0.19569991347132915,0.5272145774499792,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16630880880247612,0.0650611289367412,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01682612893553956,0.17023937991165625,0.9214842515788562,-0.3213334861033661,0.35498574397444527,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0993260476918616,-0.02644249273293539,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12020381784418967,0.12003050361184155,0.31926776019943764,-0.1182220323637337,0.35862966805211305,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06367428138933437,0.082347398643829,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21338726810660372,0.12950928462143402,0.10287131244147889,-0.04386701615051117,0.47064155236371863,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.017720527050307133,0.210722195180668,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10969809322710058,0.05025890878648905,0.03163524989204544,0.009864945007609621,0.20953124144659155,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.013593399796477217,0.10622762558237198,0.4256281587170453,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1651231510353091,0.1368186814006955,0.23060789736945192,-0.1066503519967118,0.43689665406733,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07172842484266732,0.10992185285996443,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006329739250654534,0.11066603687203538,0.954513859597004,-0.2134947481620049,0.22615422666331395,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.10102495151634144,0.08884862920300131,0.9946097045025434,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1592820778984196,0.16508379127064102,0.33717408837593865,-0.16863659364639325,0.48720074944323244,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08102234036469627,0.11144921652260242,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025797332857830015,0.10119592244621875,0.7993565536359051,-0.17521593560965706,0.22681060132531708,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.1234888603121276,0.14811955069673383,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2090238350794303,0.12182114188707105,0.08959678123530769,-0.03295889809023653,0.45100656824909713,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04783898316415546,0.16444506338357173,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012216849157397973,0.10657466245044775,0.9089894964355784,-0.19948062557404708,0.22391432388884305,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.10816880062364098,0.11632206073586013,0.9888301126476031,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07151330472357637,0.10195433906611445,0.48482787839358943,-0.13100646519120293,0.2740330746383557,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09248293844490024,-0.006403313750744377,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13955304818987524,0.10819572472234985,0.200381359842535,-0.0753644676043661,0.3544705639841166,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06023437417817632,0.0833557561262291,0.8152881775653731,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17954633428892766,0.106143082006187,0.09415379338782731,-0.031293858907744,0.3903865274855993,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.035861836894950046,0.15996247037367653,0.6707240267079618,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1390937400849741,0.12890211127067241,0.2834106626032395,-0.11695446889941613,0.39514194906936434,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0804871752977459,0.09752823638338502,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.167486287154623,0.13620479802728552,0.22199232497703184,-0.1030678119689789,0.4380403862782249,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05374253218782355,0.15401744274474746,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1628397205958174,0.2327413109181589,0.48592453167056304,-0.6251517434930886,0.2994723023014537,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.19898925071470983,-0.28116449434207835,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10352626373263801,0.06829681519122364,0.13302878674629517,-0.032136969682759,0.23918949714803503,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.02144070847205141,0.0836023066274769,0.7419804415051278,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08119697405004819,0.1576865927501324,0.6078530345958025,-0.23202807134692713,0.3944220194470235,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08173584297355033,0.051004895181661195,0.9536302663534211,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10128988629802796,0.1266604802609259,0.42596949611576007,-0.1503055980599655,0.35288537065602144,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10153546720524793,0.03986864533072655,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14257948636271056,0.16945260821867855,0.40232275476461343,-0.19401730335952094,0.47917627608494207,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06633352962121965,0.13813182693187964,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09551864248725622,0.15440518566396366,0.5377100068981628,-0.2111882908394062,0.40222557581391866,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16280730340967192,-0.01592799221510631,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14998024883010905,0.1832131854593912,0.4151471966035316,-0.21395023715468683,0.5139107348149049,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08352354807489935,0.10899529619679842,0.9275087100024864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031772724073473785,0.15845413772478575,0.8415238455323684,-0.28297695512614185,0.34652240327308936,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.047785381451790364,0.08717207555616437,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0260040815705348,0.2817978125101284,0.9266790465910016,-0.5337526553647252,0.5857608185057948,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.19387308349740207,-0.09221989225755316,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037158211281743764,0.21690077234760724,0.8643569788490434,-0.3936885276852966,0.4680049502487842,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09700152514639716,-0.005260471022050827,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12163300264432192,0.32223729667590606,0.7067076724498251,-0.761717807062956,0.518451801774312,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.221228864984718,-0.2651621332399445,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11081067629583971,0.1410142963475614,0.4340191947519395,-0.16929690041537296,0.3909182530070524,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07490981999869874,0.07881486226149562,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019489251530675114,0.2383499666604749,0.9350112767144936,-0.4539636770001313,0.4929421800614815,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16006925246636022,-0.06640091558240141,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16868658684117602,0.1529489125628157,0.27298095284533674,-0.13512763886677173,0.4725008125491238,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0650519709688174,0.1365375037843612,0.8700354117066056,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02281099960562893,0.10712327235507449,0.8318488318874853,-0.18997622130705447,0.23559822051831233,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.03082228858159109,0.05433214812443917,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053815411655336494,0.09885319183657319,0.5874996260830174,-0.14254431025019346,0.25017513356086646,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14131462581110885,-0.06367154535257702,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024609851017916937,0.13584484607308708,0.8566437293186843,-0.2452292477671769,0.2944489498030108,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14342254307760915,-0.07098203421024302,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06834264506210103,0.2767602338238287,0.8055123697788809,-0.618092850781309,0.48140756065710694,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.19346770607335242,-0.1651514243970345,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09208639849723202,0.04804381486442014,0.05841180884397264,-0.0033467377605697207,0.18751953475503375,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.02071063846441299,0.05721538584175092,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14888447743388,0.0861658959994236,0.08740160715573228,-0.02227348986938557,0.3200424447371456,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03262951091933425,0.12747748815447527,0.6570209000268399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13057518164668566,0.11552438747443591,0.2613275688754605,-0.09889982241073811,0.3600501857041094,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08270660004391274,0.08730816705760013,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15760789338359554,0.12171277854878913,0.19862484981278142,-0.08415958932653153,0.39937537609372264,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10421635033735178,0.08084009587018173,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07215369254721171,0.09103043399437698,0.4300535065453719,-0.10866708189603058,0.252974466990454,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03961519893590107,0.06481571438796685,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14918702692789362,0.13181356399546543,0.2606908253182116,-0.11264442523519527,0.41101847909098255,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03418566816939233,0.13226735225782865,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16229423240146446,0.10151644084581027,0.11335405797304886,-0.039355706492542025,0.36394417129547096,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0509278371316643,0.1323453704983603,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11002907756644774,0.18664206447015763,0.5569738715973548,-0.26071245535060006,0.48077061048349556,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14799601032742957,0.04352292445518201,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08477256063450665,0.19381905020143683,0.6628721104797243,-0.30022517277674254,0.4697702940457559,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16208015161461495,-0.02442384762130121,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20029283893280997,0.12511482097587803,0.11287127937684079,-0.04823238313284936,0.4488180609984693,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04731620716436383,0.16905737116584887,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016038484661176963,0.1891884438148985,0.9326263544435001,-0.35976111801274757,0.3918380873351015,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21241121357280557,-0.10499841638801774,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19971983055006137,0.15055636430005237,0.18797862511735358,-0.09934189194788934,0.4987815530480121,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06948322445394563,0.17590942906014173,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12489512510901014,0.09044652427597487,0.1707001074721185,-0.054765784409355214,0.3045560346273755,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.004084655694770406,0.14790744227893798,0.7844207095472905,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06323852649611483,0.17409277416403948,0.7172634785067263,-0.2825753828526929,0.40905243584492257,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12091192533939353,0.021157748493143478,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07725073052265855,0.22495382425483962,0.7320843723625734,-0.5240938678215726,0.3695924067762555,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12138877034682062,-0.13315399880833892,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06519890926488592,0.19703622478814733,0.741482186688277,-0.45658716477695305,0.3261893462471812,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.2373042696366044,-0.25127218615523156,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03761767835490232,0.2515807546579306,0.8814700693624922,-0.4621165851890062,0.5373519418988109,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1090600272886779,-0.0216163641684843,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01869594510014651,0.250637533155784,0.9407018328952513,-0.5165566150006347,0.4791647248003416,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.22757121855209603,-0.16928220752997966,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05170997436442977,0.11105894349987891,0.6426082853822568,-0.16889497379759771,0.2723149225264572,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13633104230741203,-0.026509367541506568,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3339763252383967,0.15107173649459785,0.029562352106384766,0.03389087918717826,0.6340617712896152,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.625370784552066,0.8472079453525705,0.4095391815366183,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07388674091114268,0.15560702513845567,0.6360463988885244,-0.23520749889092918,0.3829809807132145,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16266843944112316,-0.028561844491015443,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07955616093397214,0.15138013416935278,0.6004868333145879,-0.22114187921285536,0.38025420108079966,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16711552452152542,-0.03530290171758819,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10547198017110013,0.10805175815407932,0.33159049229066906,-0.10915956372092858,0.3201035240631288,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.058783075021133176,0.06721283110878737,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11498755026298743,0.12618497595439895,0.3645650694052738,-0.13566340320369322,0.3656385037296681,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.105712380618919,0.05009836554475548,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12888491038011987,0.10387810133646061,0.2178939188196121,-0.07745617695900753,0.33522599771924727,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06262598044039261,0.0917807850233847,0.8322459088982637,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09980527123877961,0.10364432558433903,0.3381198605583372,-0.10607144928707646,0.3056819917646357,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06754792735085666,0.055325999364944936,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21992990599464676,0.16437501818636827,0.18423805054603767,-0.10658087488789988,0.5464406868771934,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11408302715864313,0.15875789733570256,0.8040031034823788,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.152725122856463,0.15750898445568615,0.3348020846144366,-0.16014712548198906,0.46559737119491507,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1485466385194463,0.027425406696413263,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18708701574692743,0.12087586563823267,0.1251505770736125,-0.053018042277432315,0.4271920737712872,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.041904314318476514,0.1831359764824108,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02368980841917507,0.13711162628423781,0.8632100061248282,-0.24866559363701812,0.29604521047536825,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06125600860083107,-0.02205602046672291,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061747482673339765,0.23564659016155964,0.793887250869523,-0.40633552054022926,0.5298304858869087,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.20145498246171753,-0.04261318756934489,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015268550543302034,0.1320155608260681,0.908179065093781,-0.246964143509361,0.27750124459596504,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06010594694729261,-0.0011950879432680779,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11131745045288412,0.19824493840966143,0.5758269836387553,-0.5051066670889615,0.2824717661831932,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21752159554510367,-0.2639631948401114,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09567812888306101,0.22122233010001963,0.6664030119437552,-0.34375285367487196,0.535109111440994,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21911524703843316,-0.030017274381270977,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0857646178780232,0.1528316417713711,0.5760605700758553,-0.2178166638089184,0.3893458995649648,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08761390196440458,0.03168854107057176,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09329809482662567,0.204350511304469,0.6490758306122466,-0.49921528197558623,0.3126190923223349,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04693190157631893,-0.11151269642483112,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10795638539382114,0.24080201047909838,0.6549878198349801,-0.37036722695993235,0.5862799977475747,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.23649478599246324,-0.04575595281469026,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17049030125906903,0.11570370393823143,0.14406499268897033,-0.05934089292544928,0.4003214954435873,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04476041352548685,0.135705869273644,0.7634098210714596,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20377925524929527,0.06968559729265282,0.004357188543125652,0.06535737679515385,0.3422011337034367,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.1054394257363265,0.2869144748876474,0.11724529713671669,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0736620066460518,0.11859172229505827,0.5360606227940186,-0.16190588122400892,0.3092298945161125,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10958270855836041,-0.019167016265681076,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2135224192456683,0.08551856933870808,0.01433119965355514,0.043650286832694146,0.38339455165864245,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.268015661400606,0.4319772481416148,0.26196406695607094,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043645702916925176,0.1098900196960393,0.6921675411234611,-0.17463732170589918,0.26192872753974955,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14285557760818643,-0.07536725709066525,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20832391958525523,0.08683623073332951,0.018477388100237257,0.03583441468074569,0.38081342448976474,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.07416228165214042,0.27429731257652623,0.3094377779318214,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07315222503193278,0.1304788160235425,0.576417733306815,-0.18602791425282186,0.33233236431668745,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10745645142651465,-0.017096749582926875,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.26490605695405045,0.1452738516640645,0.0715114735473949,-0.023662603125846338,0.5534747170339472,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.0024857223368167417,0.2770996629621855,0.6190382519293574,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0824912488337531,0.05285916240078878,0.12209270226446044,-0.022506983760877286,0.18748948142838348,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.040403696626226664,0.04950538808598141,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17302273576399096,0.16622719857794632,0.3006883499613664,-0.15716717393424845,0.5032126454622303,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1291300581570879,0.07326139275808792,0.8883007525096117,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07829976918678931,0.0406382440423331,0.0571310000299343,-0.002423110374589643,0.15902264874816827,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.006276058850210039,0.06633904571382772,0.5594047727659663,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1497304329276033,0.11730258955424352,0.20504583653704084,-0.08327675111708999,0.3827376169722966,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.018509517685931502,0.13858821334767163,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13758880117499467,0.15383992767620666,0.37348688692312815,-0.16799531659843459,0.4431729189484239,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16969200587720643,-0.023927116023852772,0.915824547329523,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.4054515003885396,0.07142635409054411,1.6222969514547327e-07,0.26357182239966803,0.5473311783774112,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.21888560740066032,0.5793797627495945,1.5704625854448376e-05,0.00015008432385715643 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051327385672500225,0.08012939212636414,0.523420756034265,-0.10783980824476053,0.21049457958976098,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08160266018310407,-0.014017558743570737,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3120968418745945,0.14374797289335414,0.032522544901550744,0.026559152525249208,0.5976345312239398,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.0779353749640104,0.38241008476893185,0.4331610091082379,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03920835554892808,0.029667709937435057,0.18961985643926427,-0.019722905694711107,0.09813961679256726,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03366511540442057,0.0026325392628180236,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17899191513160684,0.04941791753879043,0.0004807335425729012,0.08082929271361043,0.27715453754960323,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.006136780825132431,0.17545440904071805,0.0194697084742025,0.18606607117729834 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09673949142988889,0.11378136339667715,0.39743280672055836,-0.12927320941987328,0.322752192279651,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09841154439937956,0.027134498956625137,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1925204342866247,0.13661709274948208,0.16218497456180667,-0.07885263765403583,0.4638935062272852,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03728703648379339,0.1657593008728859,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10943648560805469,0.0922648856410343,0.23866576477541546,-0.07383637538434215,0.29270934660045156,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.011488950376866359,0.09877941466966922,0.8459452857747916,1.0 diff --git a/results/Paper_Experiment_Section/Supplementary/ST2_Pooled_Exploratory_AxB.csv b/results/Paper_Experiment_Section/Supplementary/ST2_Pooled_Exploratory_AxB.csv new file mode 100644 index 0000000000000000000000000000000000000000..21e2d490be800911329390ba0b9a1c91d37c48d2 --- /dev/null +++ b/results/Paper_Experiment_Section/Supplementary/ST2_Pooled_Exploratory_AxB.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,DrugID,DrugName,DrugTargets,C1_beta,C1_global_BY_q,NAnnotatedTargets,MultitargetFlag,Dataset,target_equals_A,target_equals_B,response_scale,fit_status,design_tier,available_n00,available_n01,available_n10,available_n11,n00,n01,n10,n11,n_lineages,lineages_with_all_four_arms,n_total,beta_A_main_effect,beta_B_main_effect,beta_AxB_interaction,hc3_se_AxB,p_AxB,ci_low_AxB,ci_high_AxB,beta_11_vs_10_adjusted,p_11_vs_10_adjusted,beta_11_vs_01_adjusted,p_11_vs_01_adjusted,mean00,mean01,mean10,mean11,fit_df_resid,adjusted_for,burden_covariate_dropped,interpretation,q_global_BH,q_global_BY,interaction_significance,negative_interaction_direction +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.0865308434948422,1.053430644354516e-22,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,23,256,71,99,22,240,69,15,2,430.0,0.04661082844583457,-0.00426926709826945,-0.0851965616008882,0.06537462747809876,0.19323427056872905,-0.21370691076086812,0.04331378755909171,-0.08946582869915766,0.007604902853181512,-0.038585733155053634,0.5069765050119164,0.932774147742205,0.9022365701568584,0.9332706347947253,0.8697865470963827,411.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-A56085258-001-01-8,LGX818,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,309,32,72,21,225,30,68,21,13,1,344.0,0.04025412776172704,-0.1713306818997542,-0.16738081672347033,0.12583472864794815,0.18439123277618658,-0.414928570803629,0.08016693735668834,-0.3387114986232245,0.0016923210250963598,-0.12712668896174328,0.25659821642962616,1.2215222208867869,0.9177494135252938,1.2647754949090513,0.6457935031085812,327.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,322,31,72,21,237,28,69,21,13,1,355.0,0.034155512696623716,-0.10347775785925735,-0.07814731909709721,0.045551983929405654,0.08715837783765225,-0.1677484045016273,0.011453766307432903,-0.18162507695635455,0.0005271257644560777,-0.043991806400473496,0.2681727960113337,1.0146916879176873,0.8669746755639379,1.0289741812993958,0.788192922433573,338.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,301,31,67,20,224,29,64,20,13,1,337.0,0.008035751994628634,-0.039707995108453846,-0.10658792108092549,0.05155151802174997,0.0394811530514238,-0.20801063404116124,-0.0051652081206897404,-0.14629591618937934,0.0023277792646718733,-0.09855216908629685,0.05087460007837491,0.9283521429761595,0.8320110173080804,0.9224640881759445,0.6730185905149428,320.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,299,27,67,20,223,25,63,20,13,1,331.0,-0.038928842259624695,-0.3294081471044668,-0.046579776875198015,0.0951554119719546,0.6248205972100691,-0.23380258866096867,0.14064303491057265,-0.37598792397966485,0.00042048055587698234,-0.08550861913482272,0.33590637460551875,1.0875059937166094,0.7416180307575572,1.0648602949969967,0.6560785007408431,314.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,315,28,63,21,164,25,58,21,12,1,268.0,-0.024488783336151697,-0.15618322452865313,-0.12309709514193794,0.06465579060341783,0.05806443504331542,-0.2504316552067005,0.00423746492282466,-0.2792803196705911,2.0181320054143738e-06,-0.14758587847808963,0.02293541509256969,0.9445523866426543,0.7357690441802548,0.9177809445682874,0.5226571548975281,252.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,341,32,73,22,254,29,69,22,13,1,374.0,-0.017377508862216746,-0.0631567348197741,-0.004626603161099729,0.04080649450397523,0.9097937479794753,-0.08487792859339109,0.07562472227119164,-0.06778333798087383,0.14674317689753133,-0.022004112023316473,0.5589240050507245,0.8982523953944085,0.8319248644607429,0.8982007184596306,0.8185479453707852,357.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9613265021212019,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,332,32,71,21,248,29,67,21,13,1,365.0,0.045542903728094546,-0.06833876575445202,0.07498107732483437,0.05875605968815773,0.2027563560729175,-0.04058058899950155,0.1905427436491703,0.00664231157038235,0.9146695782553849,0.12052398105292891,0.022188166723654864,1.0309807745431732,0.9492998451590773,1.0836394720881928,1.0339532742795845,348.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,311,30,68,21,234,28,64,21,13,1,347.0,0.004813893579834624,8.938700845778982e-06,-0.01817810626610048,0.030446030199124317,0.5508767498162885,-0.07807088760470919,0.04171467507250823,-0.018169167565254704,0.5404716906799454,-0.013364212686265857,0.6093680096007699,0.9064701497200481,0.9001744951425368,0.9145912958711789,0.8680422038945185,330.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,311,30,74,22,231,27,70,22,13,1,350.0,0.05812360289417023,-0.1043299314655402,-0.08751390736767904,0.06881478676799384,0.20435611458389916,-0.22288039962569128,0.047852584890333186,-0.19184383883321926,0.0015348370944802217,-0.029390304473508815,0.6375421414910185,1.0311478746882898,0.9249392415724274,1.0880637911968536,0.8564169084242784,333.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,321,30,67,22,203,28,62,22,12,1,315.0,-0.0252150747149236,0.01452155810160316,0.03448466467403422,0.024671171308809987,0.1632177719319449,-0.014066465315167066,0.08303579466323552,0.04900622277563738,0.043495756262490956,0.009269589959110622,0.65610471410287,0.9415026082543605,0.963127924399852,0.9287046375728254,0.9614220211951024,299.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,318,28,66,17,203,26,61,17,12,1,307.0,0.04601373077058385,-0.04215380277534623,0.09707005583330328,0.08689269298141306,0.2648620952184888,-0.0739477591254254,0.26808787079203195,0.05491625305795705,0.5133776397658087,0.14308378660388713,0.06700097551276507,0.9738465099817348,0.9671730808246544,1.031160052652526,1.095035166763925,291.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6139984934610422,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,319,30,75,22,236,27,71,22,13,1,356.0,-0.005929118756920593,-0.026487981566249014,-0.03334033520815703,0.03213659205939696,0.3002623144137365,-0.09655257668653804,0.029871906270223972,-0.059828316774406046,0.03453315831118815,-0.039269453965077625,0.19790236786092733,0.7816684224646426,0.7412608268306835,0.7892403535070749,0.6921359210740247,339.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,255,23,51,14,159,21,47,14,11,1,241.0,0.03232881550969509,-0.23125331195804733,-0.012348941160020457,0.12361436159560284,0.9205131335889929,-0.255933048512911,0.2312351661928701,-0.24360225311806777,0.03313147416582631,0.01997987434967463,0.8603018385950916,1.1921037753381845,0.9773413008462216,1.214291258788444,0.9545493481182031,226.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9613265021212019,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,311,28,70,22,231,26,66,22,13,1,345.0,-0.01182128790980092,-0.09843322233086546,-0.05778219317369219,0.038484199004979826,0.13420062603410451,-0.13348918792148545,0.01792480157410107,-0.15621541550455764,2.918618298224803e-06,-0.06960348108349311,0.0619558540236259,0.9547269343974983,0.8435588491251861,0.9381343680605845,0.7510503833359684,328.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,295,25,62,20,221,23,59,20,13,1,323.0,0.027509597041678026,-0.2653525319706356,-0.07610298162373758,0.13893627802085406,0.5842597513980103,-0.34949438943206346,0.1972884261845883,-0.34145551359437315,0.011781266128720172,-0.04859338458205955,0.6821753839184475,1.4230170860900317,1.1015586603520833,1.4871805901858086,0.9488074257802385,306.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,313,31,65,21,240,28,63,21,13,1,352.0,0.03919932898486207,-0.09813780674393352,-0.08358820336199137,0.08467220800943882,0.32425822935645765,-0.25014441519256186,0.08296800846857912,-0.18172601010592487,0.03268545481603373,-0.044388874377129295,0.5435909429846151,1.1696511793557225,1.0272354543001396,1.2182969788592453,0.9189134073195058,335.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,335,31,73,22,249,28,69,22,13,1,368.0,-0.007875622972244839,-0.01860541750180761,-0.020237660924336723,0.046220832662226964,0.6617663836520324,-0.11114227838606947,0.07066695653739602,-0.03884307842614433,0.3644768850675628,-0.028113283896581562,0.45405360167292874,0.8848205435044063,0.8336170317074089,0.8855301296721699,0.7556827939610443,351.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8653868093911194,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,104,25,275,43,94,24,259,41,16,6,418.0,-0.003466384072166537,-0.01621948920786006,0.016981733537663423,0.016135116301885293,0.293222306716844,-0.014738974502491103,0.048702441577817945,0.0007622443298033639,0.9345708591331195,0.013515349465496887,0.3087548355813809,0.6651147314747584,0.6554962120213711,0.6645339619629823,0.664539634127245,398.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,101,26,272,43,15,7,442.0,-0.009242405075439252,-0.018483916733601623,-0.014198911901667149,0.02234658305454393,0.5255142600113653,-0.05812308737193703,0.029725263568602733,-0.03268282863526877,0.011318598502699643,-0.0234413169771064,0.2460706491662893,0.6459542240873574,0.6156595986427251,0.6251037315303961,0.5883066902607604,423.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,95,23,243,41,85,23,224,39,14,6,371.0,0.0239671256339935,-0.023882830833323224,-0.026955409994684206,0.029077423978594634,0.3545485163717058,-0.08414218352797487,0.03023136353860646,-0.05083824082800743,0.0021684463626642472,-0.0029882843606907072,0.9042995621169854,0.46931006720696467,0.4357888445110958,0.47702414390129194,0.4291179510450638,353.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,97,19,221,34,85,18,206,33,15,6,342.0,0.04774895661758885,0.001467109995094224,-0.01942590559253307,0.035740766905248786,0.5871451270070032,-0.08973998895852195,0.050888177773455806,-0.017958795597438848,0.48704883810629196,0.02832305102505578,0.37553963546944324,0.676585665541435,0.657322455863646,0.7081638910334072,0.6724435115480358,323.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,106,24,259,37,95,23,245,36,16,6,399.0,0.029530289362616393,0.01974082028186278,-0.03662253254717874,0.0603016340709392,0.5440006650036537,-0.15519019674427337,0.08194513164991588,-0.01688171226531596,0.6455921339034869,-0.007092243184562346,0.8946477601940594,0.666085752862219,0.7055121284018141,0.7187909206714768,0.6802149687232648,379.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,104,26,273,43,16,7,446.0,0.024319469408280156,0.009379840972960747,-0.09334673489228026,0.052463828053137984,0.07591022043538255,-0.19646692201392532,0.009773452229364793,-0.08396689391931952,0.009251046846988369,-0.06902726548400011,0.13241462077557561,0.6789774309435492,0.6888124287916634,0.6982660829507081,0.6169092388059537,426.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,95,23,243,41,85,23,224,39,14,6,371.0,0.002402777876994916,-0.011878267915093466,-0.0385350437293159,0.031236589190275197,0.2181538139172336,-0.09996826261733374,0.022898175158701954,-0.05041331164440936,0.00020844058612422988,-0.03613226585232098,0.18488053583363231,0.8233273337085785,0.8041056496765926,0.8143737579122192,0.7637067276141696,353.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5562922254889456,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,23,269,43,101,22,255,41,16,7,419.0,0.024991049773801708,0.010611338706961298,-0.031799107874747684,0.021421139179824474,0.13847297079774534,-0.0739115100980833,0.010313294348587937,-0.021187769167786384,0.17151872555049882,-0.006808058100945976,0.7194601693486264,0.39752957296640845,0.3962991371416434,0.4152097580162664,0.3843112336025716,399.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,23,269,43,101,22,255,41,16,7,419.0,0.005465226069926806,-0.030363100281863318,0.023356464391424626,0.02049757069824975,0.2551887920473158,-0.01694026934433111,0.06365319812718036,-0.007006635890438692,0.5521160966736767,0.028821690461351433,0.10421347254260524,0.8089111817219996,0.7764677346809458,0.8114223518371335,0.8000496913231202,399.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6139984934610422,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,110,27,287,44,100,26,271,42,16,7,439.0,0.013956379979324071,-0.020522181746168728,0.02616118340027048,0.028231892952361656,0.3546398861940553,-0.029332606652814404,0.08165497345335537,0.005639001654101753,0.792072949224875,0.04011756337959455,0.12193832295486609,0.6775167989538977,0.6598408608663351,0.6900415334018837,0.6944524982533983,419.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,109,27,286,44,100,26,270,42,16,7,438.0,-0.011965045227520526,-0.17403738453758316,0.011381564223477738,0.05463017516926703,0.8350662138453511,-0.09600253807828757,0.11876566652524304,-0.16265582031410541,7.091892246715869e-07,-0.0005834810040427872,0.9887977479187899,0.973154605314344,0.7692279672618644,0.9180997033931538,0.751352665874827,418.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,26,283,44,101,25,267,42,16,7,435.0,0.010043310927727724,-0.0052799375792580375,-3.8458138615685665e-06,0.01484525340340648,0.9997934243733477,-0.02918511181085163,0.029177420183128494,-0.0052837833931196065,0.5753108883396496,0.010039465113866155,0.43655325505525056,0.582129187740091,0.5712166444623169,0.5851339752074395,0.5795838906462085,415.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9997934243733477,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,113,27,283,44,103,26,268,42,16,7,439.0,0.023788812525049878,-0.02385079653183924,-0.010918679813728783,0.039796846985186776,0.7839428681072297,-0.08914502740923974,0.06730766778178218,-0.034769476345568026,0.08448923478940971,0.012870132711321095,0.6930413635960269,0.8323840273004508,0.8134518734374047,0.8469043690438333,0.8157826067412535,419.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,25,284,43,101,24,268,41,16,7,434.0,0.003026978037660342,-0.051459422887598485,-0.027622952183123772,0.028325999746166248,0.33004036687437277,-0.08330367048143356,0.028057766115186004,-0.07908237507072226,2.3870445736875194e-07,-0.02459597414546343,0.3273561311707791,0.9221648041081577,0.8742427704908765,0.9181818907580286,0.8376903576458784,414.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,109,26,289,42,99,25,274,40,16,7,438.0,0.05569997342599555,-0.07383289967337367,-0.012805546999585846,0.05926257088573977,0.829029602670899,-0.12929534325123643,0.10368424925206474,-0.08663844667295952,0.025361891484898456,0.042894426426409706,0.36238219260590543,0.9947434910264914,0.9128651564379914,1.0403515528428926,0.9501588997016451,418.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,101,26,272,43,15,7,442.0,-0.001406033557020201,0.004616330484701919,-0.001718955502585451,0.024009724462777847,0.942958743368624,-0.048912181765490226,0.04547427076031932,0.0028973749821164683,0.8378413454613861,-0.003124989059605652,0.8867908291070015,0.7695820167737809,0.7803433807340912,0.7711148696591511,0.779643178310328,423.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9618179182359965,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,288,45,104,26,272,43,16,7,445.0,0.023727846897180015,0.024057747658659718,-0.045752996601737775,0.035620702861477276,0.19968437864419747,-0.11576767728277884,0.024261684079303292,-0.021695248943078057,0.2745953701385982,-0.02202514970455776,0.4667198603613152,0.5823341997482866,0.6092609689912821,0.6114017307806489,0.5743803911822646,425.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,109,25,280,44,99,24,264,42,16,7,429.0,0.01315021190726561,0.01910239718472619,-0.007687815414653647,0.031501585436436864,0.807318069449751,-0.0696130357062225,0.0542374048769152,0.011414581770072542,0.554403067633949,0.005462396492611963,0.8435572427370099,1.0027582023272328,1.027620205292683,1.0208313303657994,1.0363442741253874,409.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,100,26,259,39,89,25,243,38,15,7,395.0,-0.03376109450960487,-0.023342005976489895,0.06833249480737476,0.05139965097079557,0.18451052056166975,-0.0327342908786092,0.16939928049335873,0.04499048883088486,0.21498617765551833,0.03457140029776989,0.4514362142293399,1.1969180078911703,1.1656659560021274,1.1555070545294235,1.1899888097290405,376.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,6,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,107,25,282,43,98,24,267,41,16,7,430.0,0.02803499687128947,0.034308316225099444,-0.04073646032457721,0.02604330509102342,0.11854639456851782,-0.09193152586775413,0.01045860521859971,-0.006428144099477763,0.63124993676063,-0.012701463453287737,0.5950227114795352,0.9050124356077371,0.9131538210351029,0.9188995358213182,0.9052719624519847,410.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,111,26,287,44,100,25,271,42,16,7,438.0,-0.010362791285284733,-0.008373312860676219,0.006922210373251762,0.020086645028944975,0.7305552303490923,-0.03256121317434315,0.04640563392084667,-0.0014511024874244568,0.896486269576213,-0.0034405809120329712,0.8410635723438074,0.6102484158383732,0.5955046282673064,0.5956978573297165,0.5957568409256973,418.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,101,26,272,43,15,7,442.0,0.011664366135287952,-0.013615193435277291,-0.015469185448975551,0.0162480639382876,0.34160856527994266,-0.04740618493276863,0.01646781403481753,-0.029084378884252842,0.0034391391315521684,-0.0038048193136875994,0.7830967139481572,0.6898895178819843,0.6857259559943203,0.7035821786445339,0.6834803797423844,423.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,126,9,314,13,112,7,293,11,14,1,423.0,0.03662045135618014,0.06186244511615367,-0.04449548273108957,0.14348080756926077,0.7566333792340211,-0.32655560561437963,0.23756464015220052,0.017366962385064105,0.8456342357233204,-0.007875031374909428,0.9547673915630248,0.9230013169192518,0.9803609230647188,0.9189812208037236,0.9511160720314613,405.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,97,2,235,4,89,2,220,4,14,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,139,2,332,6,127,2,315,5,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,137,2,320,6,126,2,303,5,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,131,2,304,2,119,2,286,2,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,132,2,304,3,117,2,286,3,15,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,117,2,271,2,105,2,256,2,15,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,111,2,269,2,99,2,230,1,14,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,96,262,34,55,86,254,34,54,17,3,428.0,0.007831318402705907,0.03048698831077705,-0.08470713509409133,0.05329232143486983,0.1127282828701595,-0.1894696995197337,0.02005542933155101,-0.054220146783314285,0.26504440132250817,-0.07687581669138543,0.02897424435440099,1.0494586785179019,1.0867278194188368,1.0719237019306294,1.0244539162036603,407.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,98,251,38,53,89,243,37,52,17,4,421.0,0.0003732801532880989,0.25264690762267583,0.01354841610101546,0.060855667794808194,0.8239356017214353,-0.10608849237226531,0.13318532457429622,0.2661953237236913,1.4346526005012066e-06,0.01392169625430356,0.7326638067599123,1.0056547456771872,1.2625120069218856,1.006929581215757,1.2958208046612256,400.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,87,235,35,55,78,222,34,53,16,4,387.0,0.03492342964795162,0.020187745968509252,-0.03600128495400521,0.06649505612880303,0.5885514831043521,-0.16676041801344882,0.09475784810543841,-0.015813538985495958,0.7969822118474461,-0.0010778553060535878,0.9791474474121108,1.0157877014155823,1.040785909358323,1.0839071390241586,1.0379137266750658,367.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,103,279,38,59,93,270,37,58,17,4,458.0,-0.05214247177992677,0.24669392852137864,0.07403376938982592,0.037708467868363016,0.050242800826167305,-7.872988890049448e-05,0.14814626866855235,0.3207276979112046,2.390867335799099e-22,0.02189129760989915,0.32599439699958477,0.7043850891405173,0.9477316810177814,0.6473886088587106,0.9689300737500407,437.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,19,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,120,2,282,8,109,2,260,7,15,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,108,283,28,21,98,275,28,20,17,1,421.0,-0.13380918939804787,0.23676370337402441,0.124330557245925,0.058558963774190204,0.03435318793096766,0.009208767555521705,0.23945234693632828,0.3610942606199494,2.3619389253670736e-12,-0.00947863215212287,0.8484899179609208,1.0289240777161182,1.269876493021443,0.9258966876454668,1.247853197175257,400.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,99,268,23,22,89,255,23,20,16,1,387.0,0.14545223787823744,0.03080647479751673,-0.1583834546335783,0.07194876846700224,0.02833412314597591,-0.29986703457396263,-0.016899874693193984,-0.1275769798360616,0.04905031556048347,-0.012931216755340869,0.8319640254110583,1.0100527859442476,1.0418129340769993,1.1386776299216854,1.0200800600845672,367.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,113,311,28,27,102,302,28,26,17,2,458.0,-0.07940297637131377,0.2518998445038468,0.08449644689432471,0.04532935785220292,0.06298421948312337,-0.004594205445466584,0.17358709923411603,0.3363962913981715,6.326440642913208e-16,0.005093470523010943,0.8390878783327778,0.7026282223701156,0.9505010632077114,0.6354683262888795,0.9628529639836331,437.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,241,24,63,100,233,23,60,16,2,416.0,0.07222802594411089,0.26495211617101805,-0.03485165473858358,0.06813283115253334,0.6092685062563209,-0.16879893452193984,0.09909562504477269,0.23010046143243446,0.0003102605350774541,0.03737637120552731,0.30776990949586364,0.9971495488681004,1.2676557944832247,1.0200233026084855,1.269919703095434,396.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,100,227,22,63,89,218,21,60,16,3,388.0,-0.04565077052066448,0.004975524853015924,0.029085521552697266,0.05642877382874345,0.6065566379920526,-0.0818777836661532,0.14004882677154773,0.03406104640571319,0.48809475690528614,-0.01656524896796721,0.6500274169656859,1.044010219988574,1.041530794793782,0.9985146102406497,1.0352124021187386,368.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,117,267,24,71,104,258,23,68,16,3,453.0,0.0033245833077787733,0.2647781908984173,0.003799426284185578,0.03960981266704317,0.923627423606645,-0.07405198726452748,0.08165083983289863,0.26857761718260287,1.295206190812562e-13,0.007124009591964351,0.7087070848276942,0.6889891831899823,0.9532105164194745,0.6744706218872455,0.9453367251769931,433.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9613265021212019,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,135,2,314,10,124,2,297,10,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,135,2,320,11,123,2,302,11,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,348,18,92,4,219,16,86,4,11,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False diff --git a/results/Paper_Experiment_Section/Supplementary/ST3_Four_Genotype_Raw_Arm_Coverage.csv b/results/Paper_Experiment_Section/Supplementary/ST3_Four_Genotype_Raw_Arm_Coverage.csv new file mode 100644 index 0000000000000000000000000000000000000000..9bb50b5d31962e5381d955aae335a030993a9522 --- /dev/null +++ b/results/Paper_Experiment_Section/Supplementary/ST3_Four_Genotype_Raw_Arm_Coverage.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,DrugID,DrugName,DrugTargets,C1_beta,C1_global_BY_q,NAnnotatedTargets,MultitargetFlag,Dataset,target_equals_A,target_equals_B,response_scale,n00,n01,n10,n11,n_models_with_both_known_genotype_calls,n_lineages +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.0865308434948422,1.053430644354516e-22,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,23,256,71,462,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-A56085258-001-01-8,LGX818,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,309,32,72,21,434,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,322,31,72,21,446,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,301,31,67,20,419,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,299,27,67,20,413,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,315,28,63,21,427,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,341,32,73,22,468,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,332,32,71,21,456,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,311,30,68,21,430,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,311,30,74,22,437,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,321,30,67,22,440,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,318,28,66,17,429,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,319,30,75,22,446,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,255,23,51,14,343,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,311,28,70,22,431,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,295,25,62,20,402,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,313,31,65,21,430,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,335,31,73,22,461,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,104,25,275,43,447,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,95,23,243,41,402,21 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,97,19,221,34,371,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,106,24,259,37,426,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,95,23,243,41,402,21 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,23,269,43,447,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,23,269,43,447,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,110,27,287,44,468,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,109,27,286,44,466,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,26,283,44,465,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,113,27,283,44,467,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,25,284,43,464,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,109,26,289,42,466,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,288,45,475,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,109,25,280,44,458,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,100,26,259,39,424,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,6,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,107,25,282,43,457,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,111,26,287,44,468,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,126,9,314,13,462,22 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,97,2,235,4,338,21 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,139,2,332,6,479,22 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,137,2,320,6,465,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,131,2,304,2,439,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,132,2,304,3,441,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,117,2,271,2,392,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,111,2,269,2,384,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,96,262,34,55,447,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,98,251,38,53,440,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,87,235,35,55,412,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,103,279,38,59,479,22 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,19,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,120,2,282,8,412,22 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,108,283,28,21,440,22 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,99,268,23,22,412,22 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,113,311,28,27,479,22 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,241,24,63,440,22 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,100,227,22,63,412,22 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,117,267,24,71,479,22 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,135,2,314,10,461,22 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,135,2,320,11,468,22 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+ENTREZ:7015,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Pleura,7,0,1,0 +ENTREZ:7015,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Prostate,3,0,1,0 +ENTREZ:7015,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Skin,13,4,21,2 +ENTREZ:7015,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Soft Tissue,4,2,1,0 +ENTREZ:7015,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Thyroid,4,0,4,1 +ENTREZ:7015,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Uterus,22,1,0,0 diff --git a/results/Paper_Experiment_Section/Table_Index.csv b/results/Paper_Experiment_Section/Table_Index.csv new file mode 100644 index 0000000000000000000000000000000000000000..19c360ecb4ce0534daae275165d104e67767a09c --- /dev/null +++ b/results/Paper_Experiment_Section/Table_Index.csv @@ -0,0 +1,15 @@ +id,file,title,caption,rows +T1_Raw_Source_And_Integrity,T1_Raw_Source_And_Integrity.csv,Raw data version and provenance,Provider-verified DepMap 24Q4 v1 sources downloaded afresh for this run; no historical result artifact was an input.,7 +T2_Primary_PanCancer_C1_BY,T2_Primary_PanCancer_C1_BY.csv,Primary pan-cancer C1 discoveries,"A=conditioned mutant; B=additional mutation; X=target gene. HC3 β is A+B versus A-only CRISPR effect, negative is stronger dependency; BY q<=0.05.",83 +T3_Original_Refit_Robustness,T3_Original_Refit_Robustness.csv,C2 sensitivity and refit stability,"Selected context refits with model/lineage deletions; unestimable refits retained. This is internal statistical stability, not independent replication.",546 +T4_Reactome_ORA_GSEA,T4_Reactome_ORA_GSEA.csv,Reactome functional enrichment,"Original release-locked Reactome 98 ORA and preranked GSEA, context-wise BH; associations do not prove mediation.",360965 +T5_Expression_CN_Molecular,T5_Expression_CN_Molecular.csv,Molecular expression and copy-number association,Unadjusted A+B versus A-only expression/copy-number contrasts where observed; not causal validation.,1092 +T6_C3_Four_Group_Original_Coverage,T6_C3_Four_Group_Original_Coverage.csv,C3 genetic four-group estimability and negative evidence,All originally eligible C3 four-group gene-effect contexts; low genotype-arm counts and nonestimable models remain visible.,2056 +T7_PRISM_Conditional_Drug_Response,T7_PRISM_Conditional_Drug_Response.csv,PRISM drug response A+B vs A-only,"All matched fresh-C1-target-drug candidates (including null, discordant, and underpowered); robust HC3, within-family BH/BY. Lower PRISM AUC indicates higher sensitivity.",62 +T8_PRISM_Strict_AxB_Interaction,T8_PRISM_Strict_AxB_Interaction.csv,PRISM strict four-genotype interaction,A+B interaction is secondary; FDR applies over all estimable candidate tests. Absence of significant interaction does not invalidate conditional association.,62 +T9_PRISM_AB_vs_Bonly,T9_PRISM_AB_vs_Bonly.csv,PRISM drug response A+B vs B-only,Supplementary comparison among B-mutated models. Does not define the primary directional co-mutation estimand.,62 +T10_TCGA_Patient_CoMutation_Prevalence,T10_TCGA_Patient_CoMutation_Prevalence.csv,Selected TCGA cohort mutation co-occurrence,"Selected cancer studies only, any reported nonsilent mutation, not equivalent to DepMap damaging/hotspot. Not patient drug response evidence.",168 +T11_Integrated_Candidate_Evidence,T11_Integrated_Candidate_Evidence.csv,Integrated prioritization and limitations,"Cross-assay observational evidence, compound-target annotation, TCGA descriptive co-occurrence; no causal synergy or validation inferred.",83 +ST1_Expression_Pathway_Activity,ST1_Expression_Pathway_Activity.csv,Expression-derived oncogenic pathway activity,Mean z-scored log1p TPM of measured signature genes; not pathway activation or causal mediation proof.,7938 +T12_Noncausal_Interpretation_And_Failed_Evidence,T12_Noncausal_Interpretation_And_Failed_Evidence.csv,Limitations and underpowered evidence,Negative/unavailable results are recorded; no independent/wet-lab validation claims.,11 +Experiment_Claim_to_Evidence_Registry,Experiment_Claim_to_Evidence_Registry.csv,Claim-evidence mapping,Counts measured freshly at run time; none copied from past experiments.,6 diff --git a/results/Paper_Experiment_Section/Tables/T10_TCGA_Patient_CoMutation_Prevalence.csv b/results/Paper_Experiment_Section/Tables/T10_TCGA_Patient_CoMutation_Prevalence.csv new file mode 100644 index 0000000000000000000000000000000000000000..49ecd81ae7e1d6b38e0029ec2a59381313b30876 --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T10_TCGA_Patient_CoMutation_Prevalence.csv @@ -0,0 +1,169 @@ +Study,A,B,A_symbol,B_symbol,n_mutation_profile_patients,n_A_any_reported_nonsilent,n_B_any_reported_nonsilent,n_AB_any_reported_nonsilent,AB_fraction,sample_list,sample_list_is_sequenced,TCGA_mutation_definition,interpretation +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,1066,347,6,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,1066,6,7,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,1066,347,347,81,0.07598499061913697,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,1066,347,4,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,1066,347,24,11,0.010318949343339587,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,1066,347,10,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,1066,347,10,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,1066,347,11,6,0.005628517823639775,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,1066,347,22,9,0.008442776735459663,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,1066,347,2,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,1066,6,25,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,1066,347,26,9,0.008442776735459663,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,1066,347,7,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,1066,14,9,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,1066,347,19,10,0.009380863039399626,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,1066,347,15,6,0.005628517823639775,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,1066,6,347,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,1066,347,13,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,1066,347,8,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,1066,347,14,5,0.004690431519699813,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,1066,347,30,11,0.010318949343339587,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,1066,7,347,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,1066,347,25,15,0.014071294559099437,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,1066,14,22,0,0.0,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,1066,14,7,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,1066,14,15,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,1066,347,2,0,0.0,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,1066,14,6,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,1066,347,11,5,0.004690431519699813,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,1066,187,347,83,0.07786116322701689,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,1066,347,42,7,0.006566604127579738,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,1066,347,8,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,1066,347,5,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,1066,347,6,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,1066,347,130,9,0.008442776735459663,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,1066,6,36,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,1066,347,8,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,1066,6,4,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,1066,0,109,0,0.0,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,1066,347,14,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,1066,14,17,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,1066,347,10,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,566,295,168,62,0.10954063604240283,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,566,6,41,1,0.0017667844522968198,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,566,295,28,15,0.026501766784452298,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,566,295,4,3,0.00530035335689046,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,566,295,34,24,0.04240282685512368,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,566,295,17,12,0.02120141342756184,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,566,295,37,32,0.05653710247349823,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,566,295,71,44,0.07773851590106007,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,566,295,80,55,0.09717314487632508,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,566,295,21,7,0.012367491166077738,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,566,6,47,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,566,295,30,22,0.038869257950530034,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,566,295,6,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,566,34,14,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,566,295,59,45,0.07950530035335689,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,566,295,11,7,0.012367491166077738,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,566,6,295,6,0.01060070671378092,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,566,295,64,45,0.07950530035335689,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,566,295,32,23,0.04063604240282685,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,566,295,17,13,0.022968197879858657,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,566,295,65,49,0.08657243816254417,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,566,41,295,26,0.045936395759717315,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,566,295,34,31,0.054770318021201414,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,566,34,5,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,566,34,9,1,0.0017667844522968198,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,566,34,16,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,566,295,2,1,0.0017667844522968198,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,566,34,11,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,566,295,33,21,0.037102473498233215,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,566,272,295,181,0.3197879858657244,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,566,295,8,7,0.012367491166077738,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,566,295,5,4,0.007067137809187279,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,566,295,11,8,0.014134275618374558,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,566,295,15,10,0.0176678445229682,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,566,295,6,6,0.01060070671378092,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,566,6,201,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,566,295,5,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,566,6,4,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,566,25,242,17,0.030035335689045935,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,566,295,11,6,0.01060070671378092,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,566,34,72,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,566,295,16,14,0.024734982332155476,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,534,314,218,125,0.2340823970037453,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,534,6,62,4,0.00749063670411985,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,534,314,147,66,0.12359550561797752,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,534,314,33,20,0.03745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,534,314,36,17,0.031835205992509365,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,534,314,18,7,0.013108614232209739,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,534,314,23,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,534,314,42,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,534,314,34,20,0.03745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,534,314,33,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,534,6,70,3,0.0056179775280898875,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,534,314,41,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,534,314,11,4,0.00749063670411985,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,534,387,24,20,0.03745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,534,314,30,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,534,314,24,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,534,6,314,2,0.003745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,534,314,36,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,534,314,28,14,0.026217228464419477,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,534,314,26,14,0.026217228464419477,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,534,314,62,26,0.04868913857677903,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,534,62,314,25,0.04681647940074907,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,534,314,14,7,0.013108614232209739,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,534,387,20,13,0.024344569288389514,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,534,387,17,13,0.024344569288389514,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,534,387,23,16,0.0299625468164794,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,534,314,2,1,0.0018726591760299626,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,534,387,18,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,534,314,33,9,0.016853932584269662,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,534,257,314,151,0.28277153558052437,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,534,314,27,14,0.026217228464419477,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,534,314,6,1,0.0018726591760299626,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,534,314,15,3,0.0056179775280898875,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,534,314,15,9,0.016853932584269662,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,534,314,19,6,0.011235955056179775,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,534,6,94,4,0.00749063670411985,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,534,314,14,7,0.013108614232209739,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,534,6,33,0,0.0,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,534,3,146,2,0.003745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,534,314,23,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,534,387,45,29,0.054307116104868915,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,534,314,14,10,0.018726591760299626,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,438,72,10,1,0.00228310502283105,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,438,19,233,12,0.0273972602739726,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,438,72,22,6,0.0136986301369863,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,438,72,125,25,0.05707762557077625,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,438,72,37,14,0.0319634703196347,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,438,72,26,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,438,72,61,19,0.04337899543378995,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,438,72,102,30,0.0684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,438,72,86,24,0.0547945205479452,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,438,72,30,5,0.01141552511415525,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,438,19,42,4,0.0091324200913242,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,438,72,101,26,0.0593607305936073,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,438,72,10,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,438,61,29,10,0.0228310502283105,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,438,72,85,26,0.0593607305936073,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,438,72,48,13,0.02968036529680365,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,438,19,72,4,0.0091324200913242,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,438,72,49,14,0.0319634703196347,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,438,72,52,19,0.04337899543378995,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,438,72,25,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,438,72,98,26,0.0593607305936073,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,438,233,72,37,0.08447488584474885,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,438,72,22,5,0.01141552511415525,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,438,61,10,3,0.00684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,438,61,26,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,438,61,30,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,438,72,3,1,0.00228310502283105,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,438,61,33,11,0.02511415525114155,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,438,72,19,3,0.00684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,438,351,72,70,0.1598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,438,72,13,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,438,72,5,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,438,72,18,4,0.0091324200913242,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,438,72,21,8,0.0182648401826484,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,438,72,15,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,438,19,205,13,0.02968036529680365,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,438,72,14,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,438,19,125,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,438,59,325,51,0.11643835616438356,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,438,72,36,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,438,61,70,12,0.0273972602739726,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,438,72,20,3,0.00684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence diff --git a/results/Paper_Experiment_Section/Tables/T11_Integrated_Candidate_Evidence.csv b/results/Paper_Experiment_Section/Tables/T11_Integrated_Candidate_Evidence.csv new file mode 100644 index 0000000000000000000000000000000000000000..9e0c98f7c4366105b17f8330be6243d31906b919 --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T11_Integrated_Candidate_Evidence.csv @@ -0,0 +1,84 @@ +A,B,A_symbol,B_symbol,gene,TargetGene,C1_beta,C1_global_BY_q,n_PRISM_compounds_target_annotated,n_PRISM_compounds_with_feasible_response,n_direction_consistent_PRISM_fdr_supported,smallest_annotated_target_count,n_drugs_with_clinical_phase_annotations,example_compounds,druggability_evidence,therapeutic_claim,tcga_n_AB_selected_studies,tcga_n_patients_selected_studies,n_pathways_at_BH_05,best_pathway_q,primary_evidence_tier +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ENTREZ:5290,PIK3CA,-0.6206702665037973,8.899927369258888e-08,22,22,7,1.0,22,PF-04691502 | PF-05212384 | GSK2126458 | NVP-BEZ235 | GDC-0980,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,168,2604,1,0.043314562335282296,DRUG_RESPONSE_FDR_SUPPORTED +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ENTREZ:7157,TP53,-0.8569077390316492,0.004497865529228015,3,3,1,2.0,3,nutlin-3 | aspirin | idasanutlin,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,90,2604,0,0.0615132762373489,DRUG_RESPONSE_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ENTREZ:673,BRAF,-1.0910946187228885,8.417418398503914e-08,17,17,0,1.0,17,LGX818 | AZ-628 | dabrafenib | PLX-4720 | regorafenib,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,19,2604,0,0.22274190244438216,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:7157,TP53,-0.6690480767468656,0.0017146919743462076,3,3,0,2.0,3,nutlin-3 | aspirin | idasanutlin,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,13,2604,0,0.07655187135759178,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ENTREZ:7157,TP53,-0.5935115896585544,0.011416622719899565,3,3,0,2.0,3,nutlin-3 | aspirin | idasanutlin,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,485,2604,0,0.09026408646858294,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:1719,DHFR,-0.5396753485849619,4.0947689964442364e-05,3,2,0,1.0,3,methotrexate | pralatrexate | pyrimethamine,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,66,2604,0,0.7473242853882033,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:23521,RPL13A,-0.3952742324314789,0.015161818285072143,2,2,0,13.0,2,puromycin | anisomycin,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,8,2604,3,0.0003654336256246402,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:3845,KRAS,-1.0865308434948422,1.053430644354516e-22,1,1,0,4.0,1,lonafarnib,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,191,2604,76,6.204534102939563e-08,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ENTREZ:4893,NRAS,-1.3350632067960593,6.664587881992054e-07,1,1,0,4.0,1,lonafarnib,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,50,2604,0,0.050556612065874224,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ENTREZ:9311,ASIC3,-0.0915714228989641,0.0029856584920047316,1,1,0,19.0,1,aspirin,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,60,2604,2,0.003916470266121944,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:1026,CDKN1A,-0.3248516515795884,0.04898412473432724,1,1,0,1.0,1,GGTI-298,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,13,2604,0,0.07655187135759178,PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ENTREZ:9124,PDLIM1,-0.1422393479163315,1.5696863878375136e-06,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,66,2604,0,0.8150559640549688,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:390999,PRAMEF12,-0.2093218233136288,1.95734414881598e-06,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,29,2604,0,0.4881204508760916,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:283078,MKX,-0.1815025660300815,3.740923302395388e-06,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,29,2604,0,0.4881204508760916,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:83901,KRTAP9-8,-0.1076127681410301,1.5309255044966268e-05,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,66,2604,0,0.7473242853882033,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ENTREZ:84320,ACBD6,-0.1210771384124408,2.084607723909631e-05,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,98,2604,0,0.14061387141611192,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:146325,PRR35,-0.1507807162573974,3.417850152325546e-05,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,108,2604,0,0.09089790722071839,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:51084,CRYL1,-0.135267586461926,4.0947689964442364e-05,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,31,2604,0,0.14446869304005933,NO_TARGET_DRUG_MAPPED +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:7555,CNBP,-0.3940936007462384,5.042486238696814e-05,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,8,2604,2,0.00588655122124249,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:84885,ZDHHC12,-0.08191342192341,7.378788670067345e-05,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,75,2604,0,0.37799338633918556,NO_TARGET_DRUG_MAPPED +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ENTREZ:1796,DOK1,-0.1548810330665694,9.075594194213218e-05,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY,19,2604,1,0.017682532570199628,NO_TARGET_DRUG_MAPPED 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a/results/Paper_Experiment_Section/Tables/T12_Noncausal_Interpretation_And_Failed_Evidence.csv b/results/Paper_Experiment_Section/Tables/T12_Noncausal_Interpretation_And_Failed_Evidence.csv new file mode 100644 index 0000000000000000000000000000000000000000..28498dd0bae89abd40127b4dbad42d7e59d44413 --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T12_Noncausal_Interpretation_And_Failed_Evidence.csv @@ -0,0 +1,12 @@ +Limitation,Precise_Interpretation +No verified WT,No reported damaging/hotspot genotype call is not verified wild type. +Observational conditional estimand,"A+B vs A-only is an association, not causal chronological mutation addition." +Selection and multiplicity,Drug tests are selected using C1 discovery; BH/BY applies to eligible candidate compounds only. +Sparse strata,Missing/small genotype arms and lineages lead to nonestimable tests; retained in T6-T9. +Interaction optional,Lack of A×B interaction does not refute conditional A+B vs A-only association. +Direct target mutation,"Where TargetGene equals B, associations may reflect ordinary B mutation-driven inhibitor response." +Compound annotation,Multi-target annotations do not establish causal or selective inhibition of dependency gene X. +Cross-assay cohort sharing,PRISM and CRISPR observations may come from overlapping cancer models; not independent cohort validation. +Limited TCGA,Selected prevalence only; clinical treatment sensitivity not tested. +Missing functional external validation,Wet-lab genotype perturbation and independently genotyped drug cohort not established. +Power limitation,No significant interaction is not evidence of a true zero effect; no equivalence margin was tested. diff --git a/results/Paper_Experiment_Section/Tables/T1_Raw_Source_And_Integrity.csv b/results/Paper_Experiment_Section/Tables/T1_Raw_Source_And_Integrity.csv new file mode 100644 index 0000000000000000000000000000000000000000..df0f4970398d08dc7ea618af6fd12d0f9501e705 --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T1_Raw_Source_And_Integrity.csv @@ -0,0 +1,8 @@ +role,file,official_figshare_file_id,expected_md5,actual_md5,size_ok,hash_ok,status +model,Model.csv,51065297,675210d17675f3517b0ce39a3c274f16,675210d17675f3517b0ce39a3c274f16,True,True,VERIFIED +crispr,CRISPRGeneEffect.csv,51064667,6edf7ade09b9b34199210b559d4745d3,6edf7ade09b9b34199210b559d4745d3,True,True,VERIFIED +damaging,OmicsSomaticMutationsMatrixDamaging.csv,51065747,cb20fdbe1cf3b9b0d8ed4f53e1f399b6,cb20fdbe1cf3b9b0d8ed4f53e1f399b6,True,True,VERIFIED +hotspot,OmicsSomaticMutationsMatrixHotspot.csv,51065750,a5aeb1deef897ead3c955c372148d840,a5aeb1deef897ead3c955c372148d840,True,True,VERIFIED +expression,OmicsExpressionProteinCodingGenesTPMLogp1.csv,51065489,71794802b750ce77c422dad0720a40af,71794802b750ce77c422dad0720a40af,True,True,VERIFIED +copy_number,OmicsCNGene.csv,51065324,4696565fa74dc805983bc278b4a41802,4696565fa74dc805983bc278b4a41802,True,True,VERIFIED +common_essential,CRISPRInferredCommonEssentials.csv,51064916,545edef0d377f252db6e5e675201bd77,545edef0d377f252db6e5e675201bd77,True,True,VERIFIED diff --git a/results/Paper_Experiment_Section/Tables/T2_Primary_PanCancer_C1_BY.csv b/results/Paper_Experiment_Section/Tables/T2_Primary_PanCancer_C1_BY.csv new file mode 100644 index 0000000000000000000000000000000000000000..6e3ba7fc11dd865abf31542c820d901403ed904b --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T2_Primary_PanCancer_C1_BY.csv @@ -0,0 +1,84 @@ +A,B,A_symbol,B_symbol,gene,gene_symbol,beta,ci_low,ci_high,q_global_BH,q_global_BY +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ENTREZ:3845,KRAS,-1.0865308434948422,-1.2522251612858322,-0.9208365257038522,5.879271802588757e-24,1.053430644354516e-22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ENTREZ:673,BRAF,-1.0910946187228885,-1.3059463059620786,-0.8762429314836979,4.69782143761724e-09,8.417418398503914e-08 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+ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:1026,CDKN1A,-0.3248516515795884,-0.4308883781076913,-0.2188149250514854,0.0027338390511839118,0.04898412473432724 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:124975,GGT6,-0.1387908150420942,-0.1839829004216421,-0.0935987296625463,0.002734590673397953,0.04899759208028155 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ENTREZ:1843,DUSP1,-0.1644311717459073,-0.2171387449430825,-0.1117235985487321,0.00275756311214463,0.04940920548690533 diff --git a/results/Paper_Experiment_Section/Tables/T3_Original_Refit_Robustness.csv b/results/Paper_Experiment_Section/Tables/T3_Original_Refit_Robustness.csv new file mode 100644 index 0000000000000000000000000000000000000000..0b831cb0ac4e298f2efe4cf73f596b21d62298c7 --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T3_Original_Refit_Robustness.csv @@ -0,0 +1,547 @@ +A,B,Scope,Lineage,gene,status,reason,full_beta,n_refits,n_estimable_refits,n_unestimable_refits,direction_stability,max_absolute_beta_change,min_beta,max_beta +ENTREZ:1029,ENTREZ:2195,pan_cancer_conditional,PAN_CANCER,ENTREZ:91754,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:1029,ENTREZ:7179,pan_cancer_conditional,PAN_CANCER,ENTREZ:6665,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:1029,ENTREZ:94025,pan_cancer_conditional,PAN_CANCER,ENTREZ:91612,EXECUTED,,-0.23749444786726412,43.0,36.0,7.0,1.0,0.019370310612159464,-0.2568647584794236,-0.2316416542632554 +ENTREZ:1029,ENTREZ:94025,pan_cancer_conditional,PAN_CANCER,ENTREZ:84838,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:10664,ENTREZ:27445,pan_cancer_conditional,PAN_CANCER,ENTREZ:7737,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:23224,ENTREZ:10664,pan_cancer_conditional,PAN_CANCER,ENTREZ:348013,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:2956,ENTREZ:27445,pan_cancer_conditional,PAN_CANCER,ENTREZ:64768,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:2956,ENTREZ:288,pan_cancer_conditional,PAN_CANCER,ENTREZ:3356,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:10664,pan_cancer_conditional,PAN_CANCER,ENTREZ:162333,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:10664,pan_cancer_conditional,PAN_CANCER,ENTREZ:644591,EXECUTED,,-0.2444700948887267,46.0,42.0,4.0,1.0,0.016641256447201436,-0.2542202009708324,-0.22782883844152527 +ENTREZ:324,ENTREZ:2956,pan_cancer_conditional,PAN_CANCER,ENTREZ:80167,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:55252,pan_cancer_conditional,PAN_CANCER,ENTREZ:414062,EXECUTED,,-0.17960157021702883,46.0,37.0,9.0,1.0,0.012687155529337607,-0.18405623660686993,-0.16691441468769122 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+ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7157,EXECUTED,,-0.6690480767468654,156.0,156.0,0.0,1.0,0.05772203168187051,-0.6969521665912694,-0.6113260450649949 +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7158,EXECUTED,,-0.26736802497011203,156.0,156.0,0.0,1.0,0.02195664931254604,-0.28932467428265807,-0.2482290727932757 +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:3093,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:57646,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:80731,pan_cancer_conditional,PAN_CANCER,ENTREZ:10494,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10051,pan_cancer_conditional,PAN_CANCER,ENTREZ:55847,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10051,pan_cancer_conditional,PAN_CANCER,ENTREZ:2512,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1009,pan_cancer_conditional,PAN_CANCER,ENTREZ:440023,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:9311,EXECUTED,,-0.09157142289896415,108.0,101.0,7.0,1.0,0.005954241405183108,-0.0962215279464787,-0.08561718149378104 +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:143384,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:1843,EXECUTED,,-0.16443117174590738,108.0,101.0,7.0,1.0,0.008423184661179917,-0.16932017985836392,-0.15600798708472746 +ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,ENTREZ:654346,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:54555,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:55004,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:79142,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:129684,pan_cancer_conditional,PAN_CANCER,ENTREZ:4659,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:144535,pan_cancer_conditional,PAN_CANCER,ENTREZ:392309,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:144535,pan_cancer_conditional,PAN_CANCER,ENTREZ:57139,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:50809,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:79944,EXECUTED,,-0.1757264475669164,148.0,145.0,3.0,1.0,0.017811099684393483,-0.18376516754157413,-0.15791534788252293 +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:4499,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:8387,EXECUTED,,-0.16543199722699212,148.0,145.0,3.0,1.0,0.00899003731748485,-0.17361277973199646,-0.15644195990950727 +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:55111,EXECUTED,,-0.0988522423899898,148.0,145.0,3.0,1.0,0.0068096935411101345,-0.10566193593109993,-0.09355761853204639 +ENTREZ:7157,ENTREZ:1496,pan_cancer_conditional,PAN_CANCER,ENTREZ:6434,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:23097,EXECUTED,,-0.0833633961359934,137.0,130.0,7.0,1.0,0.00301957195038359,-0.086382968086377,-0.08056795897189067 +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:51084,EXECUTED,,-0.13526758646192602,137.0,130.0,7.0,1.0,0.007332991839494457,-0.1419575899274239,-0.12793459462243156 +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:22826,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:23196,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:79066,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:9883,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:23034,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:57606,EXECUTED,,-0.1082138559686604,137.0,130.0,7.0,1.0,0.005928733149632728,-0.11414258911829313,-0.10559288987697676 +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:6510,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:6667,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1499,pan_cancer_conditional,PAN_CANCER,ENTREZ:54662,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:158358,pan_cancer_conditional,PAN_CANCER,ENTREZ:114799,EXECUTED,,-0.31685548567263705,61.0,54.0,7.0,1.0,0.017518001294283603,-0.3255429590229539,-0.29933748437835345 +ENTREZ:7157,ENTREZ:158358,pan_cancer_conditional,PAN_CANCER,ENTREZ:403239,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:158358,pan_cancer_conditional,PAN_CANCER,ENTREZ:114836,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:25841,EXECUTED,,-0.1567665833091063,127.0,120.0,7.0,1.0,0.005293541266556068,-0.16206012457566238,-0.1516388234254819 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:1719,EXECUTED,,-0.5396753485849626,127.0,120.0,7.0,1.0,0.01518735642875968,-0.5548627050137223,-0.5290207263869724 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:1876,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:203111,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:3346,EXECUTED,,-0.12598866018833998,127.0,120.0,7.0,1.0,0.004334458472692579,-0.13026213438020592,-0.1216542017156474 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:83901,EXECUTED,,-0.10761276814103016,127.0,120.0,7.0,1.0,0.005168873173904354,-0.11169821745965237,-0.1024438949671258 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:283092,EXECUTED,,-0.12307027684832164,127.0,120.0,7.0,1.0,0.007468830002295063,-0.1305391068506167,-0.1190048074412233 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:440560,EXECUTED,,-0.20678433193985,127.0,120.0,7.0,1.0,0.008233870906340562,-0.2106551876760227,-0.19855046103350943 +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:22864,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:11037,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:100287238,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2045,pan_cancer_conditional,PAN_CANCER,ENTREZ:7552,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:219285,pan_cancer_conditional,PAN_CANCER,ENTREZ:3052,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:219285,pan_cancer_conditional,PAN_CANCER,ENTREZ:79295,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26046,pan_cancer_conditional,PAN_CANCER,ENTREZ:81027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26047,pan_cancer_conditional,PAN_CANCER,ENTREZ:84320,EXECUTED,,-0.12107713841244085,108.0,101.0,7.0,1.0,0.003614442195070122,-0.12469158060751097,-0.11781668063976831 +ENTREZ:7157,ENTREZ:26047,pan_cancer_conditional,PAN_CANCER,ENTREZ:222389,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26047,pan_cancer_conditional,PAN_CANCER,ENTREZ:27319,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2625,pan_cancer_conditional,PAN_CANCER,ENTREZ:57670,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2625,pan_cancer_conditional,PAN_CANCER,ENTREZ:63933,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:284434,pan_cancer_conditional,PAN_CANCER,ENTREZ:25839,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:284434,pan_cancer_conditional,PAN_CANCER,ENTREZ:81168,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:11132,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:833,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:84248,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:9856,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:64324,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:10267,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:29072,pan_cancer_conditional,PAN_CANCER,ENTREZ:54439,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,pan_cancer_conditional,PAN_CANCER,ENTREZ:197370,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,pan_cancer_conditional,PAN_CANCER,ENTREZ:23435,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:1116,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:4744,EXECUTED,,-0.18110655386307375,127.0,120.0,7.0,1.0,0.012256084787739097,-0.18692438399754124,-0.16885046907533466 +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:341799,EXECUTED,,-0.14790657120398665,127.0,120.0,7.0,1.0,0.008626939418790724,-0.15353390692695887,-0.13927963178519592 +ENTREZ:7157,ENTREZ:343450,pan_cancer_conditional,PAN_CANCER,ENTREZ:5176,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:345895,pan_cancer_conditional,PAN_CANCER,ENTREZ:51134,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:345895,pan_cancer_conditional,PAN_CANCER,ENTREZ:613211,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:345895,pan_cancer_conditional,PAN_CANCER,ENTREZ:401089,EXECUTED,,-0.13815010630834096,127.0,120.0,7.0,1.0,0.008440698258757928,-0.1465908045670989,-0.1312767879455866 +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:79767,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:8326,EXECUTED,,-0.20106110876133212,111.0,109.0,2.0,1.0,0.020053497152356298,-0.22111460591368842,-0.18560361798441796 +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:51704,EXECUTED,,-0.09586676722466819,111.0,109.0,2.0,1.0,0.007803815281489435,-0.10367058250615763,-0.09059697361901477 +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:256957,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3717,pan_cancer_conditional,PAN_CANCER,ENTREZ:84132,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3739,pan_cancer_conditional,PAN_CANCER,ENTREZ:1551,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3739,pan_cancer_conditional,PAN_CANCER,ENTREZ:124446,EXECUTED,,-0.13485433045118464,66.0,64.0,2.0,1.0,0.010604401783674833,-0.14545873223485947,-0.12777271410551308 +ENTREZ:7157,ENTREZ:3845,pan_cancer_conditional,PAN_CANCER,ENTREZ:3845,EXECUTED,,-1.0865308434948417,376.0,376.0,0.0,1.0,0.041821250320390746,-1.1283520938152325,-1.0543818091940387 +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:54888,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:79629,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:135250,EXECUTED,,-0.11458945150876651,163.0,162.0,1.0,1.0,0.014627248850409308,-0.12921670035917582,-0.10285821370486684 +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:23521,EXECUTED,,-0.3952742324314792,163.0,159.0,4.0,1.0,0.018802536040378126,-0.4113102301763582,-0.37647169639110106 +ENTREZ:7157,ENTREZ:387,pan_cancer_conditional,PAN_CANCER,ENTREZ:55284,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:171019,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:51466,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:124975,EXECUTED,,-0.13879081504209426,137.0,130.0,7.0,1.0,0.0037758290010070916,-0.14256664404310135,-0.13610281963851234 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:23276,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:50674,EXECUTED,,-0.11881770048111831,137.0,130.0,7.0,1.0,0.002846487448179613,-0.12166418792929792,-0.11633851389084549 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:100506658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:85315,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:5549,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:146325,EXECUTED,,-0.15078071625739745,137.0,130.0,7.0,1.0,0.002794061734333886,-0.15357477799173133,-0.1489382073768901 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:5868,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:944,EXECUTED,,-0.09063115875245041,137.0,130.0,7.0,1.0,0.002383378391192542,-0.09259182686042906,-0.08824778036125787 +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:170261,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:7988,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,ENTREZ:8233,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:64902,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:130813,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:1796,EXECUTED,,-0.15488103306656947,153.0,150.0,3.0,1.0,0.011064732073976985,-0.16088840684356534,-0.1438163009925925 +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:55890,EXECUTED,,-0.09207301119395929,153.0,150.0,3.0,1.0,0.007742126767096111,-0.0998151379610554,-0.08689458325676197 +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:79568,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:283748,EXECUTED,,-0.18804130947682957,153.0,150.0,3.0,1.0,0.016174061821885355,-0.2001709677942163,-0.1718672476549442 +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:80148,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:646658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4683,pan_cancer_conditional,PAN_CANCER,ENTREZ:50837,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4741,pan_cancer_conditional,PAN_CANCER,ENTREZ:10207,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4893,pan_cancer_conditional,PAN_CANCER,ENTREZ:4893,EXECUTED,,-1.3350632067960595,187.0,187.0,0.0,1.0,0.07788993293853497,-1.4129531397345945,-1.2587829283724201 +ENTREZ:7157,ENTREZ:5290,pan_cancer_conditional,PAN_CANCER,ENTREZ:5290,EXECUTED,,-0.6206702665037975,349.0,349.0,0.0,1.0,0.08690709555491494,-0.6573355983666984,-0.5337631709488826 +ENTREZ:7157,ENTREZ:5395,pan_cancer_conditional,PAN_CANCER,ENTREZ:57224,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:546,pan_cancer_conditional,PAN_CANCER,ENTREZ:3973,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:546,pan_cancer_conditional,PAN_CANCER,ENTREZ:29993,EXECUTED,,-0.08832238394026756,186.0,186.0,0.0,1.0,0.006856030454213458,-0.09517841439448102,-0.08221361349010538 +ENTREZ:7157,ENTREZ:546,pan_cancer_conditional,PAN_CANCER,ENTREZ:9124,EXECUTED,,-0.14223934791633155,186.0,186.0,0.0,1.0,0.018111340732617345,-0.15450764562147057,-0.12412800718371421 +ENTREZ:7157,ENTREZ:54790,pan_cancer_conditional,PAN_CANCER,ENTREZ:343563,EXECUTED,,-0.23187525249115276,85.0,78.0,7.0,1.0,0.017729983956226075,-0.24960523644737884,-0.21923404338242147 +ENTREZ:7157,ENTREZ:54790,pan_cancer_conditional,PAN_CANCER,ENTREZ:641455,EXECUTED,,-0.20808043095061626,85.0,78.0,7.0,1.0,0.016962409289320468,-0.22504284023993673,-0.19771316211514817 +ENTREZ:7157,ENTREZ:54790,pan_cancer_conditional,PAN_CANCER,ENTREZ:142684,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:9847,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:3070,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:152404,EXECUTED,,-0.11532893673807437,163.0,160.0,3.0,1.0,0.010265418467701293,-0.12559435520577567,-0.10870170096304214 +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:654502,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:8581,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:4129,EXECUTED,,-0.07315444649928247,163.0,160.0,3.0,1.0,0.004957231461690165,-0.0764045100747829,-0.06819721503759231 +ENTREZ:7157,ENTREZ:55607,pan_cancer_conditional,PAN_CANCER,ENTREZ:7709,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,pan_cancer_conditional,PAN_CANCER,ENTREZ:5728,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:57492,pan_cancer_conditional,PAN_CANCER,ENTREZ:201965,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:1871,EXECUTED,,-0.5449616367402317,251.0,251.0,0.0,1.0,0.06112382296081276,-0.597273591648888,-0.4838378137794189 +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:5925,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:6502,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,pan_cancer_conditional,PAN_CANCER,ENTREZ:7027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:200894,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:64757,EXECUTED,,-0.1974744369246594,61.0,54.0,7.0,1.0,0.014354279030013017,-0.2074219143807014,-0.1831201578946464 +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:4650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:390260,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:79228,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,pan_cancer_conditional,PAN_CANCER,ENTREZ:133396,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:973,EXECUTED,,-0.08895512083944167,137.0,130.0,7.0,1.0,0.0022700872106413555,-0.09122520805008302,-0.08668898378257561 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:2793,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:10542,EXECUTED,,-0.07875000307456616,137.0,130.0,7.0,1.0,0.0035683729728258756,-0.08181537156855499,-0.07518163010174028 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:4061,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:56926,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:79751,EXECUTED,,-0.1808131138594748,137.0,130.0,7.0,1.0,0.004621857614966807,-0.1847006514342262,-0.176191256244508 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:6691,EXECUTED,,-0.08445849755687228,137.0,130.0,7.0,1.0,0.0022754105559307097,-0.08649936743165743,-0.08218308700094157 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:84885,EXECUTED,,-0.08191342192340997,137.0,130.0,7.0,1.0,0.002780892712805405,-0.08469431463621538,-0.08007723059574731 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:84107,EXECUTED,,-0.09630331063938441,137.0,130.0,7.0,1.0,0.0030516840966229586,-0.09935499473600737,-0.09343286313292043 +ENTREZ:7157,ENTREZ:80243,pan_cancer_conditional,PAN_CANCER,ENTREZ:10780,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:602,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:22943,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:3298,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:645745,EXECUTED,,-0.2553658145987826,76.0,69.0,7.0,1.0,0.009992124104016564,-0.26535793870279917,-0.2485304106368509 +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:266812,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:81832,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:283297,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:159090,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8028,pan_cancer_conditional,PAN_CANCER,ENTREZ:84690,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:81930,pan_cancer_conditional,PAN_CANCER,ENTREZ:11319,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:81930,pan_cancer_conditional,PAN_CANCER,ENTREZ:57523,EXECUTED,,-0.1017390271880533,108.0,101.0,7.0,1.0,0.004424540420635753,-0.10616356760868906,-0.0974571392427932 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:8706,EXECUTED,,-0.10772951701101978,127.0,120.0,7.0,1.0,0.006401732315852046,-0.11413124932687183,-0.1034368902760606 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:94027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:4850,EXECUTED,,-0.216565427692534,127.0,120.0,7.0,1.0,0.013810881731684072,-0.23037630942421808,-0.2073660858090756 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:23219,EXECUTED,,-0.2145057659290111,127.0,120.0,7.0,1.0,0.0072235883441073845,-0.22101973819014237,-0.20728217758490372 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:2257,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:401089,EXECUTED,,-0.13743645042902433,127.0,120.0,7.0,1.0,0.0070057830540043164,-0.14444223348302865,-0.133035545725516 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:8514,EXECUTED,,-0.15055848715366613,127.0,120.0,7.0,1.0,0.006675754390263439,-0.15495295072414822,-0.1438827327634027 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:283078,EXECUTED,,-0.1815025660300816,127.0,120.0,7.0,1.0,0.00928491568509382,-0.18570467240800814,-0.1722176503449878 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:29943,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:390999,EXECUTED,,-0.20932182331362892,127.0,120.0,7.0,1.0,0.0072737973870317385,-0.21434003625464643,-0.20204802592659718 +ENTREZ:7157,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:171017,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:84162,pan_cancer_conditional,PAN_CANCER,ENTREZ:440400,EXECUTED,,-0.4617484781692949,204.0,204.0,0.0,1.0,0.03430147344104695,-0.4939491091434202,-0.4274470047282479 +ENTREZ:7157,ENTREZ:896,pan_cancer_conditional,PAN_CANCER,ENTREZ:4804,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:896,pan_cancer_conditional,PAN_CANCER,ENTREZ:5557,EXECUTED,,-0.5040968774574668,44.0,39.0,5.0,1.0,0.024203553475771966,-0.5283004309332388,-0.4845603434388517 +ENTREZ:7157,ENTREZ:9699,pan_cancer_conditional,PAN_CANCER,ENTREZ:29980,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9699,pan_cancer_conditional,PAN_CANCER,ENTREZ:388585,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:2995,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:8284,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:119679,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,pan_cancer_conditional,PAN_CANCER,ENTREZ:51341,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:200316,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:1742,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:5325,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:116369,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9863,pan_cancer_conditional,PAN_CANCER,ENTREZ:83862,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:999,pan_cancer_conditional,PAN_CANCER,ENTREZ:136,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:999,pan_cancer_conditional,PAN_CANCER,ENTREZ:54785,EXECUTED,,-0.1445554626407886,83.0,81.0,2.0,1.0,0.011906190505561132,-0.1530301122419469,-0.13264927213522748 +ENTREZ:7157,ENTREZ:999,pan_cancer_conditional,PAN_CANCER,ENTREZ:7143,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:10350,pan_cancer_conditional,PAN_CANCER,ENTREZ:2815,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:10350,pan_cancer_conditional,PAN_CANCER,ENTREZ:4650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:9179,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:726,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:5553,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:1788,pan_cancer_conditional,PAN_CANCER,ENTREZ:163081,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:32,pan_cancer_conditional,PAN_CANCER,ENTREZ:9378,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:2815,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:6416,pan_cancer_conditional,PAN_CANCER,ENTREZ:4650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:7157,pan_cancer_conditional,PAN_CANCER,ENTREZ:7157,EXECUTED,,-0.5935115896585543,96.0,96.0,0.0,1.0,0.1378111964707649,-0.6829957971344534,-0.45570039318778943 +ENTREZ:7273,ENTREZ:7403,pan_cancer_conditional,PAN_CANCER,ENTREZ:23515,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:7403,pan_cancer_conditional,PAN_CANCER,ENTREZ:23214,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:8209,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:55756,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:83990,pan_cancer_conditional,PAN_CANCER,ENTREZ:6007,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8085,ENTREZ:2261,pan_cancer_conditional,PAN_CANCER,ENTREZ:9441,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8085,ENTREZ:84159,pan_cancer_conditional,PAN_CANCER,ENTREZ:4502,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8289,ENTREZ:23039,pan_cancer_conditional,PAN_CANCER,ENTREZ:402381,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:10664,ENTREZ:27445,within_lineage,Uterus,ENTREZ:7737,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:10664,ENTREZ:288,within_lineage,Uterus,ENTREZ:152206,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:196528,within_lineage,Bowel,ENTREZ:6648,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:1850,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:440021,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2033,within_lineage,Bowel,ENTREZ:151011,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:10845,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:84331,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:346288,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:23345,within_lineage,Bowel,ENTREZ:9618,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:288,within_lineage,Bowel,ENTREZ:731220,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:288,within_lineage,Bowel,ENTREZ:7314,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2956,within_lineage,Bowel,ENTREZ:80167,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:2956,within_lineage,Bowel,ENTREZ:57535,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:341640,within_lineage,Bowel,ENTREZ:23435,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:4144,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:23787,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:472,within_lineage,Bowel,ENTREZ:50833,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:57683,within_lineage,Bowel,ENTREZ:23397,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:57683,within_lineage,Bowel,ENTREZ:6635,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1173,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1175,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:55726,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7157,within_lineage,Bowel,ENTREZ:81832,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7273,within_lineage,Bowel,ENTREZ:390326,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7468,within_lineage,Bowel,ENTREZ:401666,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:7468,within_lineage,Bowel,ENTREZ:26595,EXECUTED,,-0.2288547916266943,39.0,34.0,5.0,1.0,0.013400075872697925,-0.23911880445688816,-0.21545471575399638 +ENTREZ:324,ENTREZ:79633,within_lineage,Bowel,ENTREZ:151011,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:80816,within_lineage,Bowel,ENTREZ:284119,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:8085,within_lineage,Bowel,ENTREZ:81930,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:8085,within_lineage,Bowel,ENTREZ:5204,EXECUTED,,-0.5257261101269711,39.0,39.0,0.0,1.0,0.027326487875779737,-0.5474334481155749,-0.4983996222511914 +ENTREZ:324,ENTREZ:8289,within_lineage,Bowel,ENTREZ:10276,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:64506,EXECUTED,,-0.20191983909934988,39.0,34.0,5.0,1.0,0.01436814150063423,-0.20918805831045695,-0.18755169759871565 +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:29926,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:81472,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:324,ENTREZ:9699,within_lineage,Bowel,ENTREZ:10490,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:10317,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:26735,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:338755,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:8771,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2033,within_lineage,Bowel,ENTREZ:123016,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2196,within_lineage,Bowel,ENTREZ:79934,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2196,within_lineage,Bowel,ENTREZ:84441,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:10845,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:84331,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:23345,within_lineage,Bowel,ENTREZ:55291,EXECUTED,,-0.5131958432361028,28.0,23.0,5.0,1.0,0.020415259050815204,-0.533611102286918,-0.49852699867591954 +ENTREZ:3845,ENTREZ:2956,within_lineage,Bowel,ENTREZ:64746,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:2956,within_lineage,Bowel,ENTREZ:339230,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7157,within_lineage,Bowel,ENTREZ:1718,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7157,within_lineage,Bowel,ENTREZ:57646,EXECUTED,,-0.28917880847941246,28.0,28.0,0.0,1.0,0.01787910174561702,-0.3070579102250295,-0.2747754248193708 +ENTREZ:3845,ENTREZ:7157,within_lineage,Pancreas,ENTREZ:1106,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:84871,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10380,EXECUTED,,-0.4669074330805235,28.0,28.0,0.0,1.0,0.047313217984109035,-0.48117298292930266,-0.4195942150964145 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:91409,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:26235,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10841,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10046,EXECUTED,,-0.27996908753499905,28.0,28.0,0.0,1.0,0.015702411776843173,-0.2956714993118422,-0.26453438161826115 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4354,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4544,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:5173,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:6166,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:6519,EXECUTED,,-0.21133668829952312,28.0,28.0,0.0,1.0,0.010742478905193309,-0.2209349257192839,-0.20059420939432981 +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:136895,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:7273,within_lineage,Bowel,ENTREZ:159195,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:3845,ENTREZ:94025,within_lineage,Bowel,ENTREZ:81168,EXECUTED,,-0.41803292124767066,28.0,23.0,5.0,1.0,0.01886203996248842,-0.4345401689552804,-0.39917088128518224 +ENTREZ:4703,ENTREZ:1387,within_lineage,Bowel,ENTREZ:647174,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:64922,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:8605,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:2956,within_lineage,Bowel,ENTREZ:83852,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:7273,within_lineage,Bowel,ENTREZ:10082,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:7273,within_lineage,Bowel,ENTREZ:90529,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5290,ENTREZ:7273,within_lineage,Uterus,ENTREZ:5338,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:1387,within_lineage,Bowel,ENTREZ:140688,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:7273,within_lineage,Bowel,ENTREZ:9455,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:9575,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:22944,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:55294,ENTREZ:8085,within_lineage,Bowel,ENTREZ:144195,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:5728,ENTREZ:19,within_lineage,Uterus,ENTREZ:5592,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7157,within_lineage,Skin,ENTREZ:11200,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7157,within_lineage,Skin,ENTREZ:7157,EXECUTED,,-0.856907739031649,37.0,37.0,0.0,1.0,0.03591038215242648,-0.8928181211840754,-0.8228339747562092 +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:567,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:23500,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:55096,EXECUTED,,-0.40543262619513415,11.0,0.0,11.0,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:79631,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:23219,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:2739,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:4124,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:673,ENTREZ:7273,within_lineage,Bowel,ENTREZ:54538,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:673,within_lineage,Skin,ENTREZ:673,EXECUTED,,-1.1788788245383204,38.0,38.0,0.0,1.0,0.05589259301261573,-1.2347714175509361,-1.1452455038615954 +ENTREZ:7015,ENTREZ:673,within_lineage,Skin,ENTREZ:140890,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,within_lineage,Skin,ENTREZ:11200,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7015,ENTREZ:7157,within_lineage,Skin,ENTREZ:7157,EXECUTED,,-0.8069694294639463,38.0,38.0,0.0,1.0,0.042063842608238367,-0.8490332720721847,-0.7704476881392625 +ENTREZ:7015,ENTREZ:80731,within_lineage,Skin,ENTREZ:10494,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10060,within_lineage,Lung,ENTREZ:5500,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10060,within_lineage,Lung,ENTREZ:65263,EXECUTED,,-0.1190434454815338,86.0,81.0,5.0,1.0,0.0057522797172862156,-0.12319170442956184,-0.11329116576424758 +ENTREZ:7157,ENTREZ:10060,within_lineage,Lung,ENTREZ:6822,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1029,within_lineage,Lymphoid,ENTREZ:8572,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1029,within_lineage,Lymphoid,ENTREZ:6229,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:10973,within_lineage,Bowel,ENTREZ:55295,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:1387,within_lineage,Lymphoid,ENTREZ:9185,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:9465,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:9530,EXECUTED,,-0.11764068032426771,86.0,81.0,5.0,1.0,0.007161484914537414,-0.12135397988139435,-0.1104791954097303 +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:220972,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:54516,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:29935,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Lung,ENTREZ:23169,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:154664,within_lineage,Uterus,ENTREZ:5326,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:54964,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:2306,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:401494,EXECUTED,,-0.2918379373043891,39.0,39.0,0.0,1.0,0.015660226876898053,-0.30749816418128717,-0.2804130841744156 +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:4191,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Bowel,ENTREZ:4646,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Esophagus/Stomach,ENTREZ:861,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:285601,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:54969,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:81875,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:1130,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:1954,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:56138,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2033,within_lineage,Lung,ENTREZ:114088,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:153579,EXECUTED,,-0.08713101022687864,86.0,81.0,5.0,1.0,0.004189052146726158,-0.09111950484918963,-0.08294195808015248 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:10944,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:100190949,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:767,EXECUTED,,-0.07977965368626128,86.0,81.0,5.0,1.0,0.0032827059496313704,-0.08306235963589265,-0.07693920698879637 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:85016,EXECUTED,,-0.14113639835941594,86.0,81.0,5.0,1.0,0.00449709358998146,-0.1456334919493974,-0.13867922840798577 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:163747,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:26052,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:2108,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:442444,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:85302,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:152273,EXECUTED,,-0.2479910577134636,86.0,81.0,5.0,1.0,0.004692038559466177,-0.2526830962729298,-0.2436700854801561 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:389816,EXECUTED,,-0.10776318026585653,86.0,81.0,5.0,1.0,0.003251409826722687,-0.11083563540598493,-0.10451177043913384 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:4528,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:57084,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:408187,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:51298,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:50859,EXECUTED,,-0.14499390340250354,86.0,81.0,5.0,1.0,0.0030968172513307357,-0.1473373631526446,-0.1418970861511728 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:23648,EXECUTED,,-0.25923676628746384,86.0,81.0,5.0,1.0,0.009213649247004185,-0.268450415534468,-0.25161440666859236 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:284297,EXECUTED,,-0.14187543885651585,86.0,81.0,5.0,1.0,0.004384131688974252,-0.1462595705454901,-0.13856838954417505 +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:10388,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:115572,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2195,within_lineage,Lung,ENTREZ:9218,EXECUTED,,-0.22627615102580598,86.0,81.0,5.0,1.0,0.0052670829390402685,-0.23154323396484625,-0.2218907502058539 +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:146223,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:3060,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:79829,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:642658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:159371,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:6672,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:126374,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2196,within_lineage,Lung,ENTREZ:220992,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Bowel,ENTREZ:5330,EXECUTED,,-0.21439323862488524,39.0,39.0,0.0,1.0,0.01360683976452498,-0.22786507281058885,-0.20078639886036026 +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:51496,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:2595,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:220064,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:55319,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:23345,within_lineage,Lung,ENTREZ:57583,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26278,within_lineage,Bowel,ENTREZ:94027,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:26278,within_lineage,Bowel,ENTREZ:55655,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:27445,within_lineage,Lung,ENTREZ:57106,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:27445,within_lineage,Lung,ENTREZ:729956,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:2956,within_lineage,Bowel,ENTREZ:412,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:10286,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:84893,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:3693,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Bowel,ENTREZ:115572,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:339479,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:57082,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:441670,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:324,within_lineage,Esophagus/Stomach,ENTREZ:85395,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,within_lineage,Bowel,ENTREZ:51704,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:341640,within_lineage,Bowel,ENTREZ:158158,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:26269,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:54545,EXECUTED,,-0.0955127359811028,49.0,44.0,5.0,1.0,0.004149771857033802,-0.0996625078381366,-0.09177836131592551 +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:23168,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:54414,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:3845,within_lineage,Esophagus/Stomach,ENTREZ:84773,EXECUTED,,-0.2426519282976816,49.0,44.0,5.0,1.0,0.010230040425879688,-0.25143068141879066,-0.2324218878718019 +ENTREZ:7157,ENTREZ:3845,within_lineage,Lung,ENTREZ:3845,EXECUTED,,-1.0159446991079832,86.0,86.0,0.0,1.0,0.0830461244324554,-1.0712496453336786,-0.9328985746755278 +ENTREZ:7157,ENTREZ:3845,within_lineage,Ovary/Fallopian Tube,ENTREZ:6484,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4089,within_lineage,Esophagus/Stomach,ENTREZ:4084,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4763,within_lineage,Lung,ENTREZ:55009,EXECUTED,,-0.151841360290641,86.0,86.0,0.0,1.0,0.01350573581783665,-0.16534709610847764,-0.14545043036658678 +ENTREZ:7157,ENTREZ:4763,within_lineage,Lung,ENTREZ:3449,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:10361,EXECUTED,,-0.10358606719021496,49.0,44.0,5.0,1.0,0.0036968298217403828,-0.10659292614913543,-0.09988923736847458 +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:5116,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:9197,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4780,within_lineage,Esophagus/Stomach,ENTREZ:53347,EXECUTED,,-0.14301327158736624,49.0,44.0,5.0,1.0,0.005857063296403009,-0.14664598044283506,-0.13715620829096323 +ENTREZ:7157,ENTREZ:4893,within_lineage,Lymphoid,ENTREZ:79705,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4893,within_lineage,Lymphoid,ENTREZ:4893,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:4893,within_lineage,Skin,ENTREZ:6197,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Bladder/Urinary Tract,ENTREZ:10908,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:732,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:22943,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:343171,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5290,within_lineage,Head and Neck,ENTREZ:7799,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Esophagus/Stomach,ENTREZ:11170,EXECUTED,,-0.1650661356552155,49.0,44.0,5.0,1.0,0.00909554274940258,-0.17416167840461808,-0.16010629953293637 +ENTREZ:7157,ENTREZ:53353,within_lineage,Esophagus/Stomach,ENTREZ:10912,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:285016,EXECUTED,,-0.154557667146096,86.0,81.0,5.0,1.0,0.003774816532125358,-0.15713187690782712,-0.15078285061397065 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:145853,EXECUTED,,-0.13021118958579977,86.0,81.0,5.0,1.0,0.004863352944119603,-0.13507454252991938,-0.12634049899929833 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:23601,EXECUTED,,-0.08942858008461964,86.0,81.0,5.0,1.0,0.0030017136904192665,-0.0924302937750389,-0.08653804895487728 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:127602,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:10056,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:3667,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:4784,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:2923,EXECUTED,,-0.11018915410380575,86.0,81.0,5.0,1.0,0.004791210396896284,-0.113043006819279,-0.10539794370690947 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:5163,EXECUTED,,-0.09541090668103583,86.0,81.0,5.0,1.0,0.003098174248773844,-0.09735852955970875,-0.09231273243226198 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:10650,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:5684,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:10556,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:55337,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:4184,EXECUTED,,-0.09473579634295122,86.0,81.0,5.0,1.0,0.003598758597001289,-0.09743609058310408,-0.09113703774594993 +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:494197,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:53353,within_lineage,Lung,ENTREZ:84619,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,within_lineage,Lung,ENTREZ:138240,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,within_lineage,Lung,ENTREZ:54827,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5728,within_lineage,Lung,ENTREZ:727800,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,within_lineage,CNS/Brain,ENTREZ:5005,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,within_lineage,CNS/Brain,ENTREZ:5925,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:5925,within_lineage,Lung,ENTREZ:10385,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:672,within_lineage,Breast,ENTREZ:79075,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:672,within_lineage,Breast,ENTREZ:8843,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:672,within_lineage,Breast,ENTREZ:113510,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:722,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:7813,EXECUTED,,-0.13653198419162485,86.0,86.0,0.0,1.0,0.008147148843735158,-0.14389742380171974,-0.1283848353478897 +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:171568,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:148867,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7015,within_lineage,Lung,ENTREZ:6727,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:97,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:53822,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:133396,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:5036,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:23645,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7179,within_lineage,Lung,ENTREZ:26191,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Bowel,ENTREZ:116987,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Bowel,ENTREZ:79837,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Head and Neck,ENTREZ:3785,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Head and Neck,ENTREZ:118987,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Lymphoid,ENTREZ:197259,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Lymphoid,ENTREZ:80003,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Ovary/Fallopian Tube,ENTREZ:57805,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Ovary/Fallopian Tube,ENTREZ:8242,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7273,within_lineage,Ovary/Fallopian Tube,ENTREZ:203430,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7399,within_lineage,Lung,ENTREZ:83715,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:7399,within_lineage,Lung,ENTREZ:79705,EXECUTED,,-0.15220697801199817,86.0,86.0,0.0,1.0,0.00868244595393039,-0.160236879245821,-0.14352453205806778 +ENTREZ:7157,ENTREZ:7399,within_lineage,Lung,ENTREZ:9260,EXECUTED,,-0.17696407562388958,86.0,86.0,0.0,1.0,0.013764918925599862,-0.19072899454948944,-0.16847727259173054 +ENTREZ:7157,ENTREZ:79776,within_lineage,Lung,ENTREZ:239,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:79776,within_lineage,Lung,ENTREZ:92675,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:79776,within_lineage,Lung,ENTREZ:79890,EXECUTED,,-0.1243793249435041,86.0,81.0,5.0,1.0,0.007139915354868076,-0.13151924029837217,-0.11813641351110794 +ENTREZ:7157,ENTREZ:8085,within_lineage,Esophagus/Stomach,ENTREZ:79675,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8085,within_lineage,Esophagus/Stomach,ENTREZ:3043,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8085,within_lineage,Esophagus/Stomach,ENTREZ:84681,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8085,within_lineage,Esophagus/Stomach,ENTREZ:64981,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8085,within_lineage,Esophagus/Stomach,ENTREZ:126014,EXECUTED,,-0.15549309694468763,49.0,44.0,5.0,1.0,0.007995786482760003,-0.16348888342744763,-0.14904384165195284 +ENTREZ:7157,ENTREZ:8085,within_lineage,Esophagus/Stomach,ENTREZ:54863,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8085,within_lineage,Lung,ENTREZ:55253,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8289,within_lineage,Bowel,ENTREZ:388960,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8289,within_lineage,Bowel,ENTREZ:10276,EXECUTED,,-0.18435203326776467,39.0,34.0,5.0,1.0,0.008956565182413279,-0.19330859845017795,-0.17631040292244282 +ENTREZ:7157,ENTREZ:8289,within_lineage,Lung,ENTREZ:140462,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8289,within_lineage,Lung,ENTREZ:6300,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:8289,within_lineage,Uterus,ENTREZ:939,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:896,within_lineage,Lymphoid,ENTREZ:4804,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:896,within_lineage,Lymphoid,ENTREZ:5557,EXECUTED,,-0.5040968774574668,44.0,39.0,5.0,1.0,0.024203553475771966,-0.5283004309332388,-0.4845603434388517 +ENTREZ:7157,ENTREZ:94025,within_lineage,Lung,ENTREZ:55509,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:952,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:23480,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:11231,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7157,ENTREZ:9817,within_lineage,Lung,ENTREZ:6899,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:6597,within_lineage,Lung,ENTREZ:6532,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:7273,ENTREZ:94025,within_lineage,Lung,ENTREZ:79641,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, +ENTREZ:8289,ENTREZ:10973,within_lineage,Bowel,ENTREZ:10658,NOT_PRIORITIZED,Original predeclared BY+precision rule,,,,,,,, diff --git a/results/Paper_Experiment_Section/Tables/T5_Expression_CN_Molecular.csv b/results/Paper_Experiment_Section/Tables/T5_Expression_CN_Molecular.csv new file mode 100644 index 0000000000000000000000000000000000000000..8f7e5cc6d5476c6ba61f7c29e18487ab74be21c2 --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T5_Expression_CN_Molecular.csv @@ -0,0 +1,1093 @@ +A,B,gene,Scope,Lineage,assay,status,n_control,n_target,delta_unadjusted,p_exploratory,not_independent_validation,q_exploratory_assay +ENTREZ:1029,ENTREZ:2195,ENTREZ:91754,pan_cancer_conditional,PAN_CANCER,expression,observed_unadjusted_only,111.0,15.0,-0.095668937420613,0.7313233439834876,True,0.8772637008759796 +ENTREZ:1029,ENTREZ:2195,ENTREZ:91754,pan_cancer_conditional,PAN_CANCER,copy_number,observed_unadjusted_only,119.0,18.0,0.14138659074687876,0.09392017121572183,True,0.5028582508777766 +ENTREZ:1029,ENTREZ:7179,ENTREZ:6665,pan_cancer_conditional,PAN_CANCER,expression,observed_unadjusted_only,120.0,6.0,0.1894145686125892,0.8649202978454119,True,0.9452967295643795 +ENTREZ:1029,ENTREZ:7179,ENTREZ:6665,pan_cancer_conditional,PAN_CANCER,copy_number,observed_unadjusted_only,131.0,6.0,-0.07158781057045072,0.5809912178030529,True,0.915350585959719 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+ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.19485059759395473,0.09610885122133443,0.054363533092143014,-0.39366690410159955,0.0039657089136900525,6.0,21.0,27.0,2.0,log_other_mut_burden|lin_Thyroid,False,23.0,0.8224714285349952,0.5226571548975281,84,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.13319065607575037,0.5965882977100995,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.042815316735061726,0.03990378092312767,0.2939579018976514,-0.12517267278582456,0.03954203931570112,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.8699215814632142,0.818547945370785,95,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.4501230372807788,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,True,18,PRISM_19Q4_secondary_AUC,TESTED,0.0608785982840076,0.10369971794157476,0.5628783135395409,-0.15364061243413896,0.27539780900215416,6.0,21.0,27.0,2.0,log_other_mut_burden|lin_Thyroid,False,23.0,0.9794298866052098,1.0339532742795845,92,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.7072060862419872,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,True,18,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=3,n1=18)",,,,,,,,,,,,,,,89,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,89.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.2575342741202116,0.1060958403810624,0.02308090898410273,-0.4765053264774024,-0.03856322176302088,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,1.111295046993353,0.8564169084242784,96,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.07539763601473558,0.3377214937346225,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,True,11,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)",,,,,,,,,,,,,,,89,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,89.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,True,11,PRISM_19Q4_secondary_AUC,TESTED,0.10241351244512537,0.13984766789971936,0.47290993297652584,-0.19029102042188556,0.3951180453121363,6.0,17.0,23.0,2.0,log_other_mut_burden|lin_Thyroid,False,19.0,1.0012989314221132,1.0950351667639253,83,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.6436829643291602,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.08381094638232552,0.03826589967674511,0.03846072450997456,-0.16278788168456187,-0.004834011080089143,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.7548257827202464,0.6921359210740247,97,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.10469863894381962,0.46896670247298183,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=12)",,,,,,,,,,,,,,,65,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,65.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.09231426695639348,0.05023764221959351,0.07854109717149599,-0.19599966447299566,0.011371130560208678,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.9026352945023399,0.7510503833359684,92,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.17493244370015015,0.783558335668724,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=3,n1=17)",,,,,,,,,,,,,,,82,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,82.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)",,,,,,,,,,,,,,,86,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,86.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.006007501054305777,0.06794656797992177,0.9302804189211749,-0.14624232497562684,0.13422732286701528,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.7664261633654079,0.7556827939610442,95,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.9302804189211749,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.004511552670644972,0.009692377959915427,0.64209329502745,-0.023622764335658845,0.014599658994368901,172.0,40.0,212.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,202.0,0.6671282769248652,0.6661029001810158,318,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.7865642864086263,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.027566942881536292,0.012396202188557187,0.02718628923825115,-0.0519986872070589,-0.0031351985560136887,186.0,42.0,228.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,218.0,0.6178485363464497,0.5908381443054405,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.08325801079214415,0.3729297263988609,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.055271610176778785,0.017011598469270955,0.0013803850062480316,-0.08883816549474026,-0.02170505485881731,153.0,38.0,191.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,181.0,0.4715494344004954,0.43082271568487546,284,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.006763886530615355,0.030296836655786783,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.02161755553951482,0.029138685566537398,0.45921169209744817,-0.07915030592282504,0.035915194843795406,143.0,32.0,175.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,165.0,0.7022406705609401,0.6717075286369466,255,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.6428963689364274,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.026994492518277104,0.04147626854619655,0.5159694014345975,-0.10883065757393254,0.05484167253737832,157.0,34.0,191.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Uterus,False,182.0,0.7282398309031367,0.6871228752477583,296,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.6653289650077704,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,True,8,PRISM_19Q4_secondary_AUC,TESTED,-0.09875185900944551,0.03401938370097454,0.004081809549508429,-0.16580431847700022,-0.031699399541890785,184.0,42.0,226.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,216.0,0.6999833982662595,0.6195971844626795,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.016548584832620554,0.07412450952407133,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.05314514117878644,0.013355195765793958,9.988105626123782e-05,-0.07949703975342634,-0.026793242604146526,153.0,38.0,191.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,181.0,0.8079357249520625,0.7664636242468199,284,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.0006117714696000817,0.002740250032470323,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.02539981880195419,0.017033899334640612,0.13750195937428855,-0.05898890057365298,0.008189262969744603,170.0,40.0,210.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,200.0,0.41404608677227606,0.38636789009503303,312,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.2564773531033418,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.01277438153136131,0.012116484214185071,0.2930186267763223,-0.03666683099700485,0.011118067934282234,170.0,40.0,210.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,200.0,0.8069763780830287,0.8024517158718085,312,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.4501230372807788,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,False,1,PRISM_19Q4_secondary_AUC,TESTED,0.0035514063092775133,0.022814254001347175,0.8764429432512255,-0.04141802658790774,0.04852083920646277,183.0,41.0,224.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,214.0,0.6870301840113612,0.6951445769222404,331,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.9195846534581363,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.16922341588870116,0.03360911496431298,1.0161443689610539e-06,-0.23547248952874836,-0.10297434224865396,182.0,41.0,223.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,213.0,0.9028386008260506,0.7538370624294827,330,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,9.958214815818327e-06,4.460488896324462e-05,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.00870896987008303,0.009757335693270102,0.3731165463313033,-0.02794384763820691,0.010525907898040848,179.0,41.0,220.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,210.0,0.582217957058203,0.5772163753537985,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.5377267873598195,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.0438056849247698,0.020966679365034945,0.037879479153284566,-0.08513668450213907,-0.0024746853474005223,180.0,41.0,221.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,211.0,0.8401633972954194,0.8179842000379882,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.10469863894381962,0.46896670247298183,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.08071036408300722,0.01490285123166759,1.662539317436933e-07,-0.11008872420598359,-0.05133200396003084,180.0,40.0,220.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,210.0,0.9109161941036883,0.8378629415109661,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,2.715480885146991e-06,1.216319647688191e-05,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.10756995225192827,0.04210456227853348,0.011315178048398543,-0.19056053381440846,-0.024579370689448085,186.0,39.0,225.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,215.0,1.0365827456977352,0.9543817464390696,331,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.0396031231693949,0.17739052071487135,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.004302021342307895,0.014311104008350391,0.7640005035280713,-0.03250785638997536,0.023903813705359572,186.0,42.0,228.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,218.0,0.77108185246105,0.7795411551803132,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.02389487429180874,0.021719802230393527,0.27249466955053925,-0.06670476677833978,0.0189150181947223,184.0,42.0,226.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,216.0,0.6034508581066104,0.5763959790894456,333,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.4450746269325474,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,0.0023312811757984983,0.019768340954863052,0.9062342267486518,-0.036635358589958096,0.04129792094155509,182.0,41.0,223.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,213.0,1.0231636683744378,1.0353064234890164,324,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.9251141064725821,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,0.05042339181015042,0.03484350030760861,0.1494313891400722,-0.018286476645994185,0.11913326026629502,172.0,37.0,209.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,199.0,1.1470527568688418,1.179827010267724,298,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.2615049309951264,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,False,6,PRISM_19Q4_secondary_AUC,TESTED,-0.02134036251741895,0.012308261183046669,0.08442390528772421,-0.04560461582101732,0.0029238907861794186,179.0,40.0,219.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,209.0,0.9150017122486291,0.8979669346766752,325,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.17985962430862984,0.8056281893531395,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,True,12,PRISM_19Q4_secondary_AUC,TESTED,-0.008218093153964368,0.012016911499799292,0.49479595805151544,-0.03190539511718067,0.015469208809251934,182.0,41.0,223.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,213.0,0.5928074424442843,0.5963698361580294,331,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.65527032282498,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.03000315966845361,0.010422387043771067,0.004390440873960556,-0.05054470066962469,-0.009461618667282536,186.0,42.0,228.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,218.0,0.7054322692599972,0.684822773147035,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.016548584832620554,0.07412450952407133,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.018788969323724994,0.08065456099181423,0.8163427172121438,-0.17909864269898573,0.14152070405153577,81.0,10.0,91.0,2.0,log_other_mut_burden|lin_Skin,False,87.0,0.8940644820057461,0.9001379603843404,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,False,1,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=14,n1=2)",,,,,,,,,,,,,,,239,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,239.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=18,n1=2)",,,,,,,,,,,,,,,338,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,338.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=18,n1=2)",,,,,,,,,,,,,,,326,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,326.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,306,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,306.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,False,3,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,307,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,307.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,True,10,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,273,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,273.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,271,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,271.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.09632427585715136,0.06447190989117807,0.1413242557916373,-0.22575703579594547,0.03310848408164274,27.0,29.0,56.0,3.0,log_other_mut_burden|lin_CNS/Brain|lin_Skin,False,51.0,1.0844214004459474,1.0260946168725,89,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.2564773531033418,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.2436267708867489,0.07101946940459876,0.0011271853230878657,0.10141273646686541,0.38584080530663234,29.0,34.0,63.0,4.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,57.0,0.9901431854794853,1.3197361547703812,91,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.006136897870145046,0.027488425700736167,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,True,19,PRISM_19Q4_secondary_AUC,TESTED,-0.07521611925019966,0.07549519946564621,0.32354644522748743,-0.2265748810164998,0.07614264251610048,26.0,34.0,60.0,4.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,54.0,1.1006767474177737,1.0455070972464928,90,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.480417448974148,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.32352405801683065,0.03815433257946742,6.61194723853692e-12,0.2472297547211868,0.3998183613124745,29.0,38.0,67.0,4.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,61.0,0.6415571202652844,0.9864986275611597,97,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,3.2398541468830907e-10,1.4511971990127463e-09,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,True,19,PRISM_19Q4_secondary_AUC,TESTED,0.05463896840826776,0.2145770388488577,0.7996661797765672,-0.37246594367899943,0.48174388049553496,78.0,5.0,83.0,2.0,log_other_mut_burden|lin_Uterus,False,79.0,1.0695073852141674,1.1102097755033007,290,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.4088092766436812,0.07192656180377399,5.588311396114635e-06,0.2609621114356579,0.5566564418517046,23.0,6.0,29.0,1.0,log_other_mut_burden,False,26.0,0.9418190395057312,1.309917232764145,49,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,4.563787640160285e-05,0.00020442141960807795,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,True,19,PRISM_19Q4_secondary_AUC,TESTED,-0.19959813366378149,0.05628614254836932,0.0016434216253352547,-0.31576702230895065,-0.08342924501861232,21.0,6.0,27.0,1.0,log_other_mut_burden,False,24.0,1.1383798772603528,0.9364634484044408,45,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.007320696331038862,0.0327909020862779,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.3295235041665884,0.053482272622677476,8.888825511072926e-07,0.22029813188890043,0.4387488764442763,25.0,9.0,34.0,2.0,log_other_mut_burden|lin_Uterus,False,30.0,0.6357420175607738,0.9637961034254001,55,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,9.958214815818327e-06,4.460488896324462e-05,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.30768660066712955,0.06407399565290699,2.334243784931109e-05,0.17808471144951973,0.43728848988473934,18.0,27.0,45.0,4.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Skin|lin_Uterus,False,39.0,0.9304552564336098,1.2380285078069493,87,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.00016339706494517765,0.0007318890055697993,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,True,19,PRISM_19Q4_secondary_AUC,TESTED,-0.01262960032266958,0.05463645769135126,0.8185016082947978,-0.12343747240132125,0.0981782717559821,16.0,26.0,42.0,4.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Skin|lin_Uterus,False,36.0,1.0083665428875372,0.9998706525738259,85,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.2963089310054027,0.04100460979648452,6.0613342954445264e-09,0.21361525429645153,0.3790026077143538,18.0,31.0,49.0,4.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Skin|lin_Uterus,False,43.0,0.6422598116998564,0.9412446479274384,95,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,1.4850269023839091e-07,6.651740428720815e-07,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,True,13,PRISM_19Q4_secondary_AUC,TESTED,0.011078445608502512,0.03710126520074646,0.7658296807567118,-0.06247842118448472,0.08463531240148975,104.0,7.0,111.0,3.0,log_other_mut_burden|lin_Lung|lin_Uterus,False,106.0,0.7394748921032596,0.7547556469436044,324,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,True,13,PRISM_19Q4_secondary_AUC,TESTED,0.004680246913723334,0.0314705174118907,0.8820505859700492,-0.05769329548031909,0.06705378930776576,106.0,8.0,114.0,3.0,log_other_mut_burden|lin_Lung|lin_Uterus,False,109.0,0.6924425452437231,0.6969233353221359,331,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.9195846534581363,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,False,4,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=21,n1=2)",,,,,,,,,,,,,,,96,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,96.0,,,False,NOT_TESTED diff --git a/results/Paper_Experiment_Section/Tables/T8_PRISM_Strict_AxB_Interaction.csv b/results/Paper_Experiment_Section/Tables/T8_PRISM_Strict_AxB_Interaction.csv new file mode 100644 index 0000000000000000000000000000000000000000..a3993ebc3903c94faf5780a1652382fc850f25f5 --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T8_PRISM_Strict_AxB_Interaction.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,DrugID,DrugName,DrugTargets,C1_beta,C1_global_BY_q,NAnnotatedTargets,MultitargetFlag,Dataset,target_equals_A,target_equals_B,response_scale,fit_status,design_tier,available_n00,available_n01,available_n10,available_n11,n00,n01,n10,n11,n_lineages,lineages_with_all_four_arms,n_total,beta_A_main_effect,beta_B_main_effect,beta_AxB_interaction,hc3_se_AxB,p_AxB,ci_low_AxB,ci_high_AxB,beta_11_vs_10_adjusted,p_11_vs_10_adjusted,beta_11_vs_01_adjusted,p_11_vs_01_adjusted,mean00,mean01,mean10,mean11,fit_df_resid,adjusted_for,burden_covariate_dropped,interpretation,q_global_BH,q_global_BY,interaction_significance,negative_interaction_direction +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.0865308434948422,1.053430644354516e-22,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,23,256,71,7,12,64,33,2,2,116.0,0.06893716805936113,0.039276513976834175,-0.069965297167565,0.08601106932121647,0.4177200762420018,-0.24041904822348792,0.10048845388835792,-0.030688783190730824,0.45816635124965466,-0.0010281291082038652,0.9893673248350887,0.8285767371424902,0.87052085127121,0.8948333039029553,0.869348625186753,110.0,log_other_mut_burden|lin_Lung,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7194067979723364,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-A56085258-001-01-8,LGX818,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,309,32,72,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,322,31,72,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,301,31,67,20,4,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,299,27,67,20,6,11,4,17,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,315,28,63,21,6,10,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,341,32,73,22,6,11,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,332,32,71,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,311,30,68,21,5,10,3,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,311,30,74,22,6,11,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,321,30,67,22,5,9,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,318,28,66,17,5,11,4,14,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,319,30,75,22,6,11,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,255,23,51,14,4,8,4,12,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,311,28,70,22,6,10,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,295,25,62,20,5,10,3,17,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,313,31,65,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,335,31,73,22,5,10,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,104,25,275,43,23,21,144,33,6,6,221.0,0.016670145644140905,0.007638032320371799,-0.012645888731947021,0.01854277551519581,0.4959965709016809,-0.0491987178012885,0.023906940337394458,-0.0050078564115752225,0.6515179461023466,0.004024256912193883,0.7169109678500301,0.6498399579570325,0.6597572874825723,0.6685239537462494,0.6616115245658355,211.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,168,39,7,7,258.0,-0.011378188738619857,-0.016586528674600063,-0.010212930519727822,0.02813460848839269,0.7169135387465532,-0.06562727052974801,0.045201409490292374,-0.026799459194327885,0.03852627659777067,-0.02159111925834768,0.30717428725160045,0.6341881271515507,0.6164869131460896,0.6210614224072644,0.5920213209716089,247.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.888972788045726,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,95,23,243,41,22,21,128,32,6,6,203.0,0.050958750989214555,0.008147016211356196,-0.07065785861222577,0.03712222233334151,0.05847857172388686,-0.1438751935961056,0.002559476371654046,-0.06251084240086957,0.0007802120269311257,-0.01969910762301122,0.4442024470112561,0.434295828278248,0.4437102541281665,0.4788515313538086,0.42727163308734795,193.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,97,19,221,34,20,16,120,26,6,6,182.0,0.05794109712833645,0.01218000752379167,-0.018919208687246388,0.042787824152653774,0.6589264559737391,-0.10337604821870212,0.06553763084420934,-0.006739201163454719,0.8369769510669496,0.03902188844109006,0.2768753819396641,0.6376495764044858,0.6571762619379815,0.7049655417963158,0.6834826428863319,172.0,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8511133389660797,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,106,24,259,37,21,19,140,31,6,6,211.0,0.03789133016854296,0.03250058661640403,-0.03437227791300379,0.07458022164238072,0.6453854261634264,-0.1814322816310161,0.11268772580500852,-0.0018716912965997604,0.9649965126160763,0.003519052255539168,0.9516610408119215,0.6698547843608885,0.7226031607838487,0.7311986974341583,0.6982159631309555,201.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8511133389660797,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,166,39,7,7,256.0,0.07275939149208684,0.04142531875772673,-0.13047440401568694,0.06714322242523242,0.05313431365793309,-0.26272600103231436,0.001777193000940508,-0.08904908525796021,0.011692621421973722,-0.057715012523600104,0.2396385983274672,0.6278646301413521,0.6743081185483546,0.7036738200893439,0.622818550234546,245.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,95,23,243,41,22,21,128,32,6,6,203.0,0.025204564635694753,0.020726937329580662,-0.0692570988523046,0.037167574123665545,0.06392876291024077,-0.14256388260879443,0.0040496849041852245,-0.04853016152272394,0.0017101281991096938,-0.04405253421660985,0.12734849098108697,0.7866327605838396,0.811344415044749,0.8089078748052413,0.7653141558715315,193.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,23,269,43,26,20,153,37,7,7,236.0,0.04499480134339713,0.021535933386696987,-0.04710443977601195,0.02481223915432374,0.058918420638332226,-0.09599852988467772,0.001789650332653818,-0.02556850638931496,0.11201105349637742,-0.002109638432614816,0.9133437137055525,0.36927788786878984,0.38985703075835476,0.41516849495656516,0.384135876081157,225.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,23,269,43,26,20,153,37,7,7,236.0,0.0049831784405988955,-0.029335338250940216,0.025487795022529125,0.029578750083313007,0.3897740078722587,-0.03279900702222684,0.0837745970672851,-0.0038475432284110905,0.7730204059467968,0.03047097346312802,0.10378235910675765,0.8007906401076527,0.7755548181711192,0.8084611952887748,0.8035261433826909,225.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,110,27,287,44,27,24,165,38,7,7,254.0,0.0032362228681579713,-0.029272666765109447,0.038175121712891676,0.03151833314387216,0.22699393007228247,-0.023908883900410564,0.10025912732619391,0.008902454947782228,0.7132602429832213,0.04141134458104965,0.14393601056558097,0.6881328919652387,0.6585279723619152,0.6883092117381057,0.6967937208051362,243.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5864009860200631,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,109,27,286,44,27,24,164,38,7,7,253.0,-0.0022591111696113795,-0.16302883863805184,-0.0010056087022817044,0.06929581179458444,0.9884336017539428,-0.13750554750739366,0.13549433010283027,-0.16403444734033354,6.752744054232745e-06,-0.003264719871893084,0.9419054345349489,0.9265482658834119,0.7656954466718041,0.9154827525923138,0.7604616338544229,242.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9949638637299998,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,26,283,44,27,23,161,38,7,7,249.0,0.0076734988098081346,-0.005685624081194723,0.0001293682566934966,0.020474401813396284,0.9949638637299998,-0.04020482514385186,0.040463561657238856,-0.005556255824501226,0.5996558130302048,0.007802867066501631,0.5703612969012686,0.5773909802392874,0.5702040174350762,0.5840884293185764,0.5791309765125094,238.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9949638637299998,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,113,27,283,44,26,24,163,38,7,7,251.0,0.051547387741240784,0.003424592111501954,-0.05031249327080605,0.04651436242995849,0.28049147922745427,-0.14194102581863843,0.04131603927702634,-0.04688790115930409,0.0336652818417517,0.001234894470434733,0.9716373793952314,0.8063133107201321,0.8163268371699995,0.8503938756041423,0.8190280483021364,240.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.668864296619314,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,25,284,43,27,22,162,37,7,7,248.0,0.003586243261420763,-0.05152243617078806,-0.03114175868966075,0.03588043397614651,0.38630981509251794,-0.10182707512633342,0.03954355774701192,-0.08266419486044882,1.0530034856783706e-06,-0.027555515428239988,0.3086429009885947,0.9147104330383843,0.8705474540302155,0.9157543742486377,0.8394902565078605,237.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,109,26,289,42,26,23,168,36,7,7,253.0,0.14784976197120092,0.002007765728123531,-0.10174426458291345,0.0695346503183757,0.1447056733311694,-0.23871467112680378,0.035226141960976884,-0.09973649885478993,0.023257239071715452,0.04610549738828747,0.3691862827993515,0.9022101850501415,0.9161590829790441,1.0458918832921642,0.9612939537157001,242.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4485875873266252,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,168,39,7,7,258.0,0.0007149792461472191,0.005073949433970782,-0.0009645908893846124,0.02632567571692802,0.9708010952787895,-0.05281603022159488,0.05088684844282565,0.00410935854458617,0.7856045259111841,-0.0002496116432373933,0.9914879218478698,0.7746544190022375,0.7804220394767638,0.7712391825913081,0.7829337234748218,247.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9949638637299998,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,288,45,27,24,166,39,7,7,256.0,-0.002952743316925712,0.0018653635187036999,-0.015289287154364714,0.04899161050126951,0.7552453848727977,-0.1117877645163118,0.08120919020758237,-0.013423923635661014,0.5472918491892791,-0.018242030471290426,0.5747647433496255,0.6021408446325394,0.6023240085133699,0.6060695379678454,0.5795109219201394,245.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9004848819637202,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,109,25,280,44,25,22,164,38,7,7,249.0,0.052747380589037086,0.05465827471888046,-0.055385489300728216,0.0353336314403238,0.11832629259692337,-0.1249920906093506,0.014221112007894166,-0.0007272145818477543,0.972294607481135,-0.0026381087116911298,0.9284026020807452,0.9718664962245056,1.0312517225301563,1.0246464394629862,1.0348704504832542,238.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4485875873266252,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,100,26,259,39,23,23,157,35,7,7,238.0,-0.08210343926983481,-0.0603171437322107,0.1008596169913151,0.06781400745859395,0.13832391326481366,-0.03276581723648128,0.23448505121911148,0.0405424732591044,0.2770262364845008,0.01875617772148029,0.6956301129134019,1.231197954630989,1.1704600589678562,1.15442761138992,1.1819407959863095,227.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4485875873266252,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,6,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,107,25,282,43,26,23,162,37,7,7,248.0,0.04028541573807884,0.02746009391102816,-0.047861318854231755,0.02306285127587469,0.039041893113263795,-0.09329568961604837,-0.0024269480924151363,-0.020401224943203594,0.09914301868445242,-0.0075759031161529156,0.7133372974760972,0.8733025632058489,0.9000092378865243,0.9127047874027736,0.8951134615346998,237.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,111,26,287,44,26,23,164,38,7,7,251.0,0.006421749942353287,0.010653468563542448,-0.014786436736696149,0.023308744991097523,0.5264416837971981,-0.06070227837124332,0.031129404897851022,-0.0041329681731537005,0.7361028917576236,-0.008364686794342862,0.6067401148754841,0.5937593917214798,0.5988155920529126,0.5980820217865975,0.5985945604827884,240.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,168,39,7,7,258.0,0.024202717723320298,0.003980972622271865,-0.03379790741988856,0.019174988501371382,0.07920406834216334,-0.07156524770264383,0.003969432862866697,-0.029816934797616698,0.006609583447452828,-0.009595189696568265,0.4908722558752342,0.685927966515258,0.6903214665117012,0.7079402663374535,0.6857544083048009,247.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4092210197678439,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,126,9,314,13,24,2,10,4,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,97,2,235,4,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,139,2,332,6,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,137,2,320,6,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,131,2,304,2,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,132,2,304,3,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,117,2,271,2,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,111,2,269,2,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,96,262,34,55,16,20,27,29,3,3,92.0,-0.01909203969482917,0.043547544626747675,-0.11930361389440697,0.0879133884557818,0.1783553756489049,-0.29409898279861635,0.05549175500980244,-0.07575606926765929,0.2143151008807582,-0.13839565358923614,0.021418469484927295,1.0935040192557122,1.141211711155972,1.0844214004459474,1.0260946168725,85.0,log_other_mut_burden|lin_CNS/Brain|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.502637876828732,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,98,251,38,53,20,23,29,34,4,4,106.0,-0.033049492547606626,0.20814575634740817,0.07893961968505336,0.08966114259266987,0.38078488447525516,-0.09898999971681086,0.2568692390869176,0.28708537603246154,1.639304655503293e-05,0.04589012713744674,0.44608473874378696,1.0514731251058782,1.274167930484132,0.9901431854794854,1.3197361547703812,98.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,87,235,35,55,18,22,26,34,4,4,100.0,-0.04759920122733137,-0.13385727594329444,0.08277686288834052,0.09492232721143314,0.3854521454632128,-0.10574707235944475,0.2713007981361258,-0.05108041305495392,0.4593931912301701,0.03517766166100915,0.5707903600882867,1.1297725400104375,0.9800192406205359,1.1006767474177737,1.0455070972464928,92.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,103,279,38,59,20,27,29,38,4,4,114.0,-0.06270831068146217,0.2318840807628262,0.10819948157923687,0.06386852138723229,0.09318321221060982,-0.018426074032575013,0.23482503719104875,0.34008356234206305,1.3804610181237192e-16,0.0454911708977747,0.2248842216718609,0.7076865638071071,0.941867144007823,0.6415571202652844,0.9864986275611597,106.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4126685112184149,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,19,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,120,2,282,8,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,108,283,28,21,3,7,23,6,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,99,268,23,22,3,6,21,6,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,113,311,28,27,7,22,25,9,2,2,63.0,-0.033227052296769116,0.3173426658241724,0.015563881525019418,0.09860907272398277,0.8751452873362575,-0.18189738057747104,0.21302514362750988,0.33290654734919184,9.837506095969906e-10,-0.017663170771749698,0.7315044598221876,0.6483589519628248,0.9618057680417923,0.6357420175607738,0.9637961034254001,57.0,log_other_mut_burden|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9689108538365708,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,241,24,63,23,14,9,13,2,2,59.0,0.04492568058829746,0.42672075618429134,-0.07452004592073153,0.11084233594928133,0.5043089861834928,-0.2968416173626804,0.14780152552121734,0.3522007102635598,0.00043693313441426387,-0.029594365332434064,0.7254201394263124,0.9188246775933123,1.3604016038145137,0.9298162518012715,1.2750866472934017,53.0,log_other_mut_burden|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,100,227,22,63,22,40,11,18,3,3,91.0,-0.14293387698261684,-0.08753737500420368,0.06348284586548616,0.0877012314907643,0.47116677750168423,-0.11092067088272217,0.2378863626136945,-0.024054529138717515,0.6956592133184683,-0.07945103111713067,0.12229362828781055,1.1429589939214162,1.0382021670159278,1.002282057948361,0.9890185149265882,84.0,log_other_mut_burden|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,117,267,24,71,25,45,12,22,3,3,104.0,-0.01786374508021854,0.33421755100883577,-0.014052639796129363,0.05498800054538934,0.7988330480941352,-0.12318859943183547,0.09508331983957674,0.3201649112127064,3.545987753191552e-13,-0.0319163848763479,0.45215641171465737,0.6446065274827206,0.947017059489352,0.6076103385150696,0.9237291446996422,97.0,log_other_mut_burden|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9171786848488219,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,135,2,314,10,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,135,2,320,11,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,348,18,92,4,13,4,21,2,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False diff --git a/results/Paper_Experiment_Section/Tables/T9_PRISM_AB_vs_Bonly.csv b/results/Paper_Experiment_Section/Tables/T9_PRISM_AB_vs_Bonly.csv new file mode 100644 index 0000000000000000000000000000000000000000..1fe9fa2cee0263f10a7292237e7eb8e0b3643cbd --- /dev/null +++ b/results/Paper_Experiment_Section/Tables/T9_PRISM_AB_vs_Bonly.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,DrugID,DrugName,DrugTargets,C1_beta,C1_global_BY_q,NAnnotatedTargets,MultitargetFlag,Dataset,target_equals_A,target_equals_B,response_scale,fit_status,n01_all,n11_all,beta_AB_vs_Bonly,hc3_se,p,ci_low,ci_high,n01,n11,n_lineages,adjusted_for,q_global_BH,q_global_BY,comparison_significance,AB_more_sensitive_than_Bonly +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.0865308434948422,1.053430644354516e-22,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,71,-0.04678645765697929,0.06887573456997671,0.499133396322501,-0.18408772514930144,0.09051480983534288,19.0,58.0,3.0,log_other_mut_burden|lin_Lung|lin_Pancreas,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-A56085258-001-01-8,LGX818,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,32,21,-0.0208908707780976,0.12398021274590107,0.8674926256361671,-0.2757358478865033,0.2339541063303081,11.0,18.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,31,21,-0.03504040606320478,0.044872235515854134,0.441917992405065,-0.12727660714375913,0.05719579501734957,11.0,18.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,31,20,-0.09743723955892963,0.074750924513628,0.2038316173439083,-0.251089965462463,0.05621548634460374,11.0,18.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,20,0.023282729872312488,0.0834897916085377,0.7826390857542975,-0.14866771470680934,0.19523317445143434,11.0,17.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,28,21,-0.07792439712376831,0.09508466924538733,0.4202308533275897,-0.273754939210439,0.11790614496290236,10.0,18.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,32,22,0.02835739557895264,0.03216224561354126,0.38572211619480545,-0.03763408144944544,0.09434887260735073,11.0,19.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,32,21,0.0956389322294939,0.054650693702356125,0.09191255064603512,-0.01669717751795366,0.20797504197694147,11.0,18.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,30,21,-0.050623678398953265,0.035820574552495626,0.1699109377296784,-0.12439753267159158,0.02315017587368505,10.0,18.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,30,22,-0.01463801721489948,0.08529863527896724,0.8650246280835178,-0.18965636009440615,0.16038032566460717,11.0,19.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,30,22,0.013863275196253522,0.024827815693967713,0.5815541435727127,-0.03727056840612626,0.0649971187986333,9.0,19.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,28,17,0.1749145378320323,0.10593353613465026,0.11290756766819209,-0.04477816974545562,0.39460724540952025,11.0,14.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,30,22,0.0018439503005056208,0.037213713288925324,0.9608455004937766,-0.07451228225725921,0.07820018285827045,11.0,19.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,14,0.17869713652434432,0.1355255957671527,0.20480880563887496,-0.107236876620317,0.46463114966900565,8.0,12.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,28,22,-0.036318850575265654,0.06544087068652343,0.5836469850691031,-0.17083448676183588,0.09819678561130457,10.0,19.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,25,20,-0.05334251696445533,0.1482352392765245,0.722106245621534,-0.3592850140898597,0.252599980160949,10.0,17.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,31,21,-0.00573401029880394,0.07977214934060249,0.94324761010228,-0.16970801165222785,0.15823999105461997,11.0,18.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,31,22,-0.024005482022132898,0.03614972990191773,0.5125002052268022,-0.09831231603451326,0.05030135199024746,10.0,19.0,1.0,log_other_mut_burden,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,25,43,0.016756621074001665,0.013663123369475942,0.2256759354133389,-0.010673243654381253,0.04418648580238459,23.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.029576859727889877,0.021356619470641616,0.17177724292063198,-0.07239430377029304,0.013240584314513283,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,41,-0.027244051409367292,0.02728968034670358,0.3234585739096675,-0.082208289077138,0.027720186258403414,21.0,32.0,6.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,19,34,0.03857491657879045,0.03790992200831928,0.3160823483465395,-0.038467314271279335,0.11561714742886023,16.0,26.0,6.0,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,24,37,-0.003398761256202046,0.07048631514193959,0.961770483822092,-0.14564590414324496,0.1388483816308409,19.0,31.0,6.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.0528665754736742,0.05114156701605674,0.3058698458031309,-0.15539924394964785,0.04966609300229944,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,41,-0.04333760370493518,0.03413353689819519,0.21073654203634132,-0.11208607604607952,0.025410868636209158,21.0,32.0,6.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,43,-0.005396406179219888,0.02196617880365997,0.8069859989910774,-0.049562368774047294,0.03876955641560752,20.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,43,0.02889252833315223,0.020463558264676825,0.16442919725837893,-0.012252213178475607,0.07003726984478006,20.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,44,0.03951930865555302,0.03250420423947355,0.22944071170651756,-0.025675868828765144,0.10471448613987118,24.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,44,0.005207464991089893,0.04740034963453943,0.9129342943242722,-0.08986559646505438,0.10028052644723415,24.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,26,44,0.0019798995766215285,0.014840432957856073,0.8943821200007238,-0.027799607803992536,0.03175940695723559,23.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,44,0.0002629983310577788,0.03749714787079176,0.9944301595699432,-0.07494675584662475,0.0754727525087403,24.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,25,43,-0.02383422207052581,0.0298862446223082,0.42893300789024114,-0.08386251103313531,0.036194066892083696,22.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,26,42,0.06467211465726078,0.05726896966795195,0.26417291628215506,-0.0503559962099262,0.17970022552444775,23.0,36.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.005307190860076513,0.026086239757762558,0.8395496851708368,-0.0576069526571225,0.04699257093696947,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.017944683718208287,0.03331771340892108,0.5923812108528816,-0.08474267726153967,0.04885330982512309,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,25,44,-0.0002252171972839806,0.030550874611264427,0.9941469101028874,-0.06155865723581257,0.061108222841244605,22.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True 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Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,26,44,-0.009357365866852421,0.016406492450829605,0.57089985246891,-0.04227940152557835,0.023564669791873508,23.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.011006718180141317,0.01563416232191564,0.48444707717673685,-0.04235132640752008,0.020337890047237447,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=4)",9,13,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,4,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,6,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,6,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,2,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,3,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,2,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,2,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,262,55,-0.07991442176337735,0.03898291669779807,0.041732285165870825,-0.15680674319993265,-0.0030221003268220414,151.0,51.0,9.0,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,251,53,0.009531902896789728,0.04579466542472409,0.8353515508428239,-0.08083154245134616,0.09989534824492563,142.0,49.0,9.0,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,235,55,0.03705225816339394,0.04643267281655742,0.4259585318082594,-0.054584218352986075,0.12868873467977396,136.0,51.0,9.0,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,279,59,0.004664108492295024,0.024710884720833316,0.8504777374692635,-0.04405595829317165,0.0533841752777617,161.0,55.0,9.0,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,19,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,8,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,283,21,-0.03984843614707069,0.06318601761167451,0.5310296554848969,-0.1666404565121089,0.08694358421796751,41.0,17.0,4.0,log_other_mut_burden|lin_Ovary/Fallopian Tube|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,268,22,-0.00834690547666922,0.0639171333952621,0.8969438288281566,-0.13870675849141917,0.12201294753808073,20.0,16.0,3.0,log_other_mut_burden|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,311,27,-0.012143128821491406,0.024550916577871607,0.6215942978626242,-0.060650803374563626,0.036364545731580815,135.0,24.0,6.0,log_other_mut_burden|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Thyroid|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,241,63,0.019227571948157378,0.040671642709722636,0.6368792624888377,-0.060947243452023604,0.09940238734833837,166.0,57.0,10.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,227,63,-0.022284893007098044,0.04058226002478291,0.5835295354950886,-0.10230889829640347,0.05773911228220738,155.0,57.0,10.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,267,71,0.009868865169738013,0.019373442218148556,0.6109486599310505,-0.02829894828498626,0.04803667862446229,182.0,65.0,10.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,10,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,11,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=2)",18,4,,,,,,,,,,,,NOT_ESTIMABLE,False diff --git a/results/Therapeutic/01_C1_And_Coverage/01_Freshly_Computed_C1_BY_05.csv b/results/Therapeutic/01_C1_And_Coverage/01_Freshly_Computed_C1_BY_05.csv new file mode 100644 index 0000000000000000000000000000000000000000..c336235694a47d0c786d69fb03c3a449a93be894 --- /dev/null +++ b/results/Therapeutic/01_C1_And_Coverage/01_Freshly_Computed_C1_BY_05.csv @@ -0,0 +1,84 @@ 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+-0.1387908150420942,0.0228446087182016,-6.075429732859101,1.2564280084251556e-08,-0.1839829004216421,-0.0935987296625463,135.0,ENTREZ:124975,ENTREZ:7157,ENTREZ:460,pan_cancer_conditional,PAN_CANCER,conditional,2.2510164198945086e-05,0.002734590673397953,0.04899759208028155,2.0614001215747637e-06,1.6774760007862984e-05,True,True,precision_eligible,True,pan_cancer_conditional,-0.025507553,0.001697792869269949,False,TP53,ASTN1,GGT6 +-0.1644311717459073,0.0265730774860246,-6.187885909427877,1.2832262362176438e-08,-0.2171387449430825,-0.1117235985487321,106.0,ENTREZ:1843,ENTREZ:7157,ENTREZ:127255,pan_cancer_conditional,PAN_CANCER,conditional,0.0001008098972477,0.00275756311214463,0.04940920548690533,0.00027113314749751654,0.0022063613132868444,True,True,precision_eligible,True,pan_cancer_conditional,0.024370236,0.007640067911714771,False,TP53,LRRIQ3,DUSP1 diff --git a/results/Therapeutic/01_C1_And_Coverage/02_Target_Drug_Arm_Coverage.csv b/results/Therapeutic/01_C1_And_Coverage/02_Target_Drug_Arm_Coverage.csv new file mode 100644 index 0000000000000000000000000000000000000000..45cdd60fbccacb1a9f820f5cd2128c294ddcd293 --- /dev/null +++ b/results/Therapeutic/01_C1_And_Coverage/02_Target_Drug_Arm_Coverage.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,C1_beta,C1_global_BY_q,n10_all_genotyped,n11_all_genotyped,Dataset,DrugID,DrugName,DrugTargets,DrugMOA,NAnnotatedTargets,MultitargetFlag,n10_matched_drug_response,n11_matched_drug_response,n_lineages_in_both_arms,n_lineages_with_min_2_per_arm,supported_lineages,n_unique_model_ids,feasibility_status,independence +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,971,171,PRISM_19Q4_secondary_AUC,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",farnesyltransferase inhibitor,4,False,256,71,10,6,Bowel | Breast | Esophagus/Stomach | Lung | Ovary/Fallopian Tube | Uterus,327,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-A56085258-001-01-8,LGX818,BRAF,RAF inhibitor,1,False,72,21,2,2,Skin | Thyroid,93,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",RAF inhibitor,2,False,72,21,2,2,Skin | Thyroid,93,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",RAF inhibitor,2,False,67,20,2,2,Skin | Thyroid,87,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",RAF inhibitor,5,False,67,20,2,2,Skin | Thyroid,87,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",RAF inhibitor,5,False,63,21,2,2,Skin | Thyroid,84,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",RAF inhibitor,2,False,73,22,2,2,Skin | Thyroid,95,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK","FGFR inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RAF inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor",18,True,71,21,2,2,Skin | Thyroid,92,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK","FGFR inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RAF inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor",18,True,68,21,2,1,Skin,89,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",RAF inhibitor,2,False,74,22,2,2,Skin | Thyroid,96,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET","FLT3 inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RAF inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor",11,True,67,22,2,1,Skin,89,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET","FLT3 inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RAF inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor",11,True,66,17,2,2,Skin | Thyroid,83,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K31866293-001-01-6,TAK-632,BRAF,RAF inhibitor,1,False,75,22,2,2,Skin | Thyroid,97,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",RAF inhibitor,2,False,51,14,2,1,Skin,65,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",RAF inhibitor,2,False,70,22,2,2,Skin | Thyroid,92,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K67578145-001-09-7,GDC-0879,BRAF,RAF inhibitor,1,False,62,20,2,1,Skin,82,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K78809024-001-05-7,SB-590885,BRAF,RAF inhibitor,1,False,65,21,1,1,Skin,86,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,-1.0910946187228885,8.417418398503914e-08,244,74,PRISM_19Q4_secondary_AUC,BRD-K93123848-001-04-1,RAF265,BRAF,"RAF inhibitor, VEGFR inhibitor",1,False,73,22,2,2,Skin | Thyroid,95,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA","mTOR inhibitor, PI3K inhibitor",2,False,275,43,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,318,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA","mTOR inhibitor, PI3K inhibitor",2,False,289,45,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,334,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG","mTOR inhibitor, PI3K inhibitor",5,False,243,41,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,284,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG","mTOR inhibitor, PI3K inhibitor",5,False,221,34,10,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,255,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG","mTOR inhibitor, PI3K inhibitor",5,False,259,37,10,7,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Uterus,296,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK","mTOR inhibitor, PI3K inhibitor",8,True,289,45,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,334,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",PI3K inhibitor,5,False,243,41,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,284,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",PI3K inhibitor,4,False,269,43,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,312,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",PI3K inhibitor,2,False,269,43,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,312,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,Pim kinase inhibitor,1,False,287,44,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,331,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K44844162-001-01-6,taselisib,PIK3CA,PI3K inhibitor,1,False,286,44,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,330,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC","DNA protein kinase inhibitor, PI3K inhibitor",5,False,283,44,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,327,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",PI3K inhibitor,4,False,283,44,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,327,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",PI3K inhibitor,4,False,284,43,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,327,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA","mTOR inhibitor, PI3K inhibitor",2,False,289,42,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,331,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",PI3K inhibitor,4,False,289,45,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,334,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",mTOR inhibitor,4,False,288,45,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,333,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",PI3K inhibitor,4,False,280,44,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,324,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",PI3K inhibitor,4,False,259,39,10,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,298,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC","mTOR inhibitor, PI3K inhibitor",6,False,282,43,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,325,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",protein tyrosine kinase inhibitor,12,True,287,44,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,331,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1045,97,PRISM_19Q4_secondary_AUC,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG","mTOR inhibitor, PI3K inhibitor",5,False,289,45,11,8,Bladder/Urinary Tract | Bowel | Breast | Esophagus/Stomach | Head and Neck | Lung | Ovary/Fallopian Tube | Uterus,334,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,-1.3350632067960593,6.664587881992054e-07,1094,48,PRISM_19Q4_secondary_AUC,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",farnesyltransferase inhibitor,4,False,314,13,5,2,Lung | Skin,327,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,-0.5396753485849619,4.0947689964442364e-05,1125,17,PRISM_19Q4_secondary_AUC,BRD-A55424491-001-19-9,methotrexate,DHFR,dihydrofolate reductase inhibitor,1,False,235,4,3,1,Bowel,239,UNDERPOWERED_OR_SPARSE_ARMS,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,-0.5396753485849619,4.0947689964442364e-05,1125,17,PRISM_19Q4_secondary_AUC,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",dihydrofolate reductase inhibitor,2,False,332,6,5,1,Bowel,338,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,-0.5396753485849619,4.0947689964442364e-05,1125,17,PRISM_19Q4_secondary_AUC,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",dihydrofolate reductase inhibitor,2,False,320,6,5,1,Bowel,326,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,-0.0731544464992825,0.004497865529228015,1132,10,PRISM_19Q4_secondary_AUC,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",acetylcholine release enhancer,2,False,304,2,2,0,,306,UNDERPOWERED_OR_SPARSE_ARMS,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,-0.0731544464992825,0.004497865529228015,1132,10,PRISM_19Q4_secondary_AUC,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",monoamine oxidase inhibitor,3,False,304,3,3,0,,307,UNDERPOWERED_OR_SPARSE_ARMS,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,-0.0731544464992825,0.004497865529228015,1132,10,PRISM_19Q4_secondary_AUC,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",monoamine oxidase inhibitor,10,True,271,2,2,0,,273,UNDERPOWERED_OR_SPARSE_ARMS,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,-0.0731544464992825,0.004497865529228015,1132,10,PRISM_19Q4_secondary_AUC,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",monoamine oxidase inhibitor,2,False,269,2,2,0,,271,UNDERPOWERED_OR_SPARSE_ARMS,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,-0.3248516515795884,0.04898412473432724,139,179,PRISM_19Q4_secondary_AUC,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,GGTase inhibitor,1,False,34,55,7,3,Bladder/Urinary Tract | CNS/Brain | Skin,89,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,-0.6690480767468656,0.0017146919743462076,139,179,PRISM_19Q4_secondary_AUC,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",MDM inhibitor,2,False,38,53,7,4,Bladder/Urinary Tract | CNS/Brain | Liver | Skin,91,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,-0.6690480767468656,0.0017146919743462076,139,179,PRISM_19Q4_secondary_AUC,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",cyclooxygenase inhibitor,19,True,35,55,7,4,Bladder/Urinary Tract | CNS/Brain | Liver | Skin,90,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,-0.6690480767468656,0.0017146919743462076,139,179,PRISM_19Q4_secondary_AUC,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",MDM inhibitor,2,False,38,59,7,4,Bladder/Urinary Tract | CNS/Brain | Liver | Skin,97,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,-0.0915714228989641,0.0029856584920047316,1132,10,PRISM_19Q4_secondary_AUC,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",cyclooxygenase inhibitor,19,True,282,8,5,2,Lung | Uterus,290,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,-0.8569077390316492,0.004497865529228015,99,70,PRISM_19Q4_secondary_AUC,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",MDM inhibitor,2,False,28,21,2,1,Skin,49,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,-0.8569077390316492,0.004497865529228015,99,70,PRISM_19Q4_secondary_AUC,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",cyclooxygenase inhibitor,19,True,23,22,2,1,Skin,45,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,-0.8569077390316492,0.004497865529228015,99,70,PRISM_19Q4_secondary_AUC,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",MDM inhibitor,2,False,28,27,3,2,Skin | Uterus,55,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,-0.5935115896585544,0.011416622719899565,84,189,PRISM_19Q4_secondary_AUC,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",MDM inhibitor,2,False,24,63,8,4,Bowel | Esophagus/Stomach | Skin | Uterus,87,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,-0.5935115896585544,0.011416622719899565,84,189,PRISM_19Q4_secondary_AUC,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",cyclooxygenase inhibitor,19,True,22,63,8,4,Bowel | Esophagus/Stomach | Skin | Uterus,85,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,-0.5935115896585544,0.011416622719899565,84,189,PRISM_19Q4_secondary_AUC,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",MDM inhibitor,2,False,24,71,8,4,Bowel | Esophagus/Stomach | Skin | Uterus,95,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,-0.3952742324314789,0.015161818285072143,1122,20,PRISM_19Q4_secondary_AUC,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",protein synthesis inhibitor,13,True,314,10,6,3,Bowel | Lung | Uterus,324,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,-0.3952742324314789,0.015161818285072143,1122,20,PRISM_19Q4_secondary_AUC,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",DNA synthesis inhibitor,13,True,320,11,6,3,Bowel | Lung | Uterus,331,FEASIBLE_FOR_FOLLOWUP_MODELING,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,-1.43378483684841,0.02245943944149391,299,19,PRISM_19Q4_secondary_AUC,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",farnesyltransferase inhibitor,4,False,92,4,3,1,Skin,96,UNDERPOWERED_OR_SPARSE_ARMS,DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT diff --git a/results/Therapeutic/01_C1_And_Coverage/03_C1_Target_Mapping_Completeness.csv b/results/Therapeutic/01_C1_And_Coverage/03_C1_Target_Mapping_Completeness.csv new file mode 100644 index 0000000000000000000000000000000000000000..877c89a271f76e8704db5b3a8866ba37aca7f146 --- /dev/null +++ b/results/Therapeutic/01_C1_And_Coverage/03_C1_Target_Mapping_Completeness.csv @@ -0,0 +1,84 @@ +A,B,A_symbol,B_symbol,TargetGene,C1_beta,C1_global_BY_q,n10_all_genotyped,n11_all_genotyped,Dataset,n_target_matched_drugs,n_drugs_with_response_coverage 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b/results/Therapeutic/02_Oncogenic_Pathway_Activity/Oncogenic_Pathway_A_B_Comparison_HC3.csv @@ -0,0 +1,7939 @@ +A,B,A_symbol,B_symbol,Pathway,n_genes_measured,score_definition,dataset,fit_status,beta_AB_vs_Aonly,hc3_se,p,ci_low,ci_high,n10,n11,n_total,n_lineages,adjusted_for,burden_not_adjusted_due_to_collinearity,fit_df_resid,mean10,mean11,q_global_BH,q_global_BY +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0426018649765227,0.03332044672516434,0.20148598343973548,-0.10802366331418024,0.022819933361134845,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06843985453172931,0.06269712983162766,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05803211865290875,0.03178085463771033,0.06828158708603649,-0.12043106186805075,0.004366824562233251,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.026297406174217434,-0.05236253322994277,0.6029135019899418,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009911008487422764,0.02316826253760413,0.6689421697404337,-0.03557785941615027,0.055399876390995806,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.008125240680896852,0.03597338044572321,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09976101155495137,0.03577523107971309,0.005440548742853352,-0.17000256541180606,-0.02951945769809669,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.1264703351744605,-0.019668968860681035,0.13931314813151582,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10157520222985301,0.02514579623016735,5.960159033504899e-05,-0.15094678549759577,-0.05220361896211026,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07732602582114324,0.009465366443111313,0.003112614632102756,0.02974630957888826 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08181662485852323,0.02819158317366536,0.0038242604323287977,0.026464903904135625,0.13716834581291082,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.029748652212092302,0.09044149878808869,0.10540617816606249,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09700326644181795,0.03420452915023539,0.004702623121750462,-0.16416088370783294,-0.02984564917580297,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07184836118072971,-0.01600554382027794,0.12484756635603735,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016471875607682585,0.024847410999097357,0.5076027283605875,-0.0323138542177276,0.06525760543309278,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.012981030864392945,0.10398742272336135,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039137857618533216,0.019851459583163058,0.04906234074000529,-0.07811447147578478,-0.00016124376128165419,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.055519780555722084,0.029545952676093157,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12860848530432253,0.03485732803004151,0.00024235447383817463,-0.19704781637873825,-0.060169154229906804,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.11574372366977231,-0.04472005672862575,0.010628783499046576,0.10157604515147735 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028439811121770582,0.02216121370570597,0.19981331216239143,-0.0719514262549941,0.015071804011452923,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05503330394651619,0.053895236095282996,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12211229813655523,0.03568966442617234,0.0006595417271079105,-0.1921858493132975,-0.052038746959812976,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.11918099506235784,-0.03803193387078309,0.02604203861514191,0.24887582764720492 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08219265056711404,0.025360616103224716,0.001248615771827638,-0.13198601396673798,-0.03239928716749009,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06489862465242523,-0.015438489104477844,0.043314562335282296,0.4139440736449076 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07415787589378872,0.020924207554798686,0.00042054194610729594,-0.11524073706658047,-0.03307501472099697,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04886999681452277,-0.014069651603122162,0.01747781135183097,0.16703011733956535 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15922941413415562,0.05435268197721144,0.0035066165823567455,0.05251265163833639,0.26594617662997483,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.041867362253873254,0.10597222358581576,0.0990587986859354,0.946674754347594 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19723148643051197,0.04346365049375522,6.7047737785246125e-06,0.11189438993013907,0.2825685829308849,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.16976858312629384,0.09671521082347326,0.00043270320531649085,0.004135212682087226 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09494057826913414,0.019799027819046053,1.99240556080727e-06,-0.13381424691899269,-0.05606690961927561,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.046925180398125,-0.07167309910301643,0.00015505603276164812,0.0014818232572164937 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024165173461427082,0.02284312233366166,0.29048306992021516,-0.06901565686105754,0.020685309938203382,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05725811058156672,0.05312326285147296,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.085358518846818,0.02249439154612472,0.00016085329457839732,-0.12952429968394819,-0.04119273800968782,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05708156884388069,-0.02664603617823522,0.007254849161155216,0.06933238277238057 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021091057823307263,0.02023410539433963,0.2976141628772995,-0.060818963441441415,0.018636847794826886,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03604903076120341,0.02194479157662932,0.8847007730863069,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11443992464018893,0.030414655053788497,0.0001824271626818183,-0.1741564538287259,-0.054723395451651946,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05116555037755165,-0.07270678661365616,0.008135431558248729,0.07774784041480882 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007707148054194894,0.0328120960209798,0.8143659143259456,-0.07213084400960405,0.05671654790121426,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03162219919819894,0.0208771392455774,0.9769437249386967,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03299258755577286,0.02384588429467639,0.16693647790729607,-0.07981190682772177,0.01382673171617605,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.031143951616398668,-0.06073114872265837,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06473026767895997,0.038195048692531666,0.0905786539626569,-0.13972292289965593,0.010262387541735987,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09273504688319678,-0.024796407328539938,0.6632964530955446,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0632575160888566,0.020394340765343046,0.0020025579763523703,-0.1033000299178233,-0.023215002259889907,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03667609141726461,-0.02787031543880958,0.06384058319793219,0.6101050004444529 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020893221250378874,0.022616920486171966,0.3559205294239659,-0.06529957700153756,0.02351313450077981,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04432531259571649,0.0976869730122281,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04214734665831906,0.018755974228149345,0.024946625977266913,-0.07897307032587102,-0.005321622990767105,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.009814260802964964,-0.06267597950168048,0.372930917151685,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010994244113156191,0.02411798878820961,0.648639725406455,-0.05834781688565187,0.03635932865933948,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04247782583674324,0.15613041535617903,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0604896828275692,0.02123076599733174,0.004514413661798833,-0.10217444483234941,-0.01880492082278898,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.024014678244284354,-0.04083332714560629,0.12065796514262335,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06387805986480073,0.01987824735275138,0.0013725520511380137,-0.10290726917716062,-0.024848850552440842,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08302575510528654,0.05668974133970641,0.04737094861710241,0.4527097212988421 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09914984464535724,0.021184391485642058,3.449328901946934e-06,-0.14074355433091756,-0.05755613495979693,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07558735186671024,-0.03278145391617982,0.00024447118592548894,0.0023363366298721016 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12441092581430836,0.03460903771480842,0.00034786515620070845,-0.19236276045548734,-0.056459091173129375,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05424708890676622,-0.07463489996716952,0.014845987150114105,0.14187857539985768 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053571973469212865,0.03415272563300522,0.11720023280133124,-0.120627879035941,0.013483932097515257,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06551031160906688,-0.004186464702277137,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05070181627340771,0.021152080698320804,0.01679472001038306,-0.09223208653903174,-0.009171546007783679,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.031622227439205945,-0.022744877993526244,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09507850371785367,0.03066539271648061,0.0020106054146281356,-0.15528733449344923,-0.034869672942258116,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07250174948591454,-0.07552617515103949,0.06384074312527256,0.6101065288213128 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020978403844733432,0.022412494034686755,0.34959402843767606,-0.06498338604306252,0.023026578353595655,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03425189326494409,0.10345356430959926,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08348516323823775,0.02538430874432584,0.0010571320603707608,-0.13332504507745493,-0.033645281399020566,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.049677312797725255,-0.03622673798398761,0.03797065291956154,0.36287395972779296 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021041230284852826,0.024312238755925763,0.38708850114785753,-0.06877619596962975,0.0266937353999241,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.030257930170070602,0.1476929483937824,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05298140558588784,0.017559870242655158,0.0026453373680683286,-0.08745868313639624,-0.018504128035379444,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.00660184611901304,-0.02843484036050227,0.07894243619446013,0.7544288077723469 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04272089362826334,0.01780692868207137,0.016699378689825677,-0.07768324893101258,-0.00775853832551409,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04640385129270479,0.019890535562393605,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05267097649043118,0.020226908004694084,0.009412661316034776,-0.09238475066015372,-0.012957202320708648,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.013636813742301331,-0.020131727278732237,0.19871730193267034,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03652925847552122,0.020234658657191925,0.07146701886755592,-0.07625825037713317,0.0031997334260907284,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.060804010286709446,0.011454642972004199,0.6190382519293574,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040234219211206276,0.019091642332599024,0.03544142171565132,-0.07771899799944201,-0.0027494404229705394,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.040476918567638125,0.011396013323360151,0.45085577817121814,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08865269524680056,0.01963876658493476,7.47504066517901e-06,-0.12721170490586425,-0.05009368558773685,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05976430133136543,-0.006664683620113138,0.00047852316774347564,0.004573100100975748 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05507916212320202,0.01652883569353454,0.000907311639351528,-0.0875320930343004,-0.022626231212103637,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03668070859022824,-0.0025426112593589048,0.03365532613631977,0.32163369660480573 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05030477406365386,0.018754766843073582,0.007488383234630566,-0.08712812713564946,-0.013481420991658263,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.034779300035228965,-0.0036554475257099123,0.1708126037830386,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07532293801920426,0.021546737870000332,0.0005029533179959198,-0.1176280833070959,-0.03301779273131262,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05874826594295723,-0.028982549621907695,0.02016385574874551,0.19269982516307485 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01700322807958757,0.014960015810330761,0.2561097969827943,-0.0463759176339711,0.012369461474795961,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03237412929265398,0.008006027821425557,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05534200496731107,0.017803540279820222,0.0019579066177863084,-0.0902977074370239,-0.02038630249759825,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03923173719358295,0.01943789018054011,0.06317830378856795,0.603775797935576 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061980219016699735,0.018389791737431372,0.0007925741788051308,-0.0980869752208161,-0.025873462812583375,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04435472986437047,-0.006860498865882217,0.03004088652499707,0.28709159861307076 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048811492330973046,0.018573663266670516,0.008780231592031123,-0.08527926428632288,-0.012343720375623216,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.07684820350681985,-0.17577280853814706,0.19294802921843934,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01068469465267676,0.025051033039379535,0.6698642966000159,-0.03850082933414791,0.059870218639501434,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03294426240400227,0.1994054613102579,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020656589777046836,0.04066473455153643,0.6116348130326135,-0.10049825832454047,0.059185078770446806,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.024185078385234197,0.006384962664966863,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03331523669706891,0.02623732440160155,0.20459702452367562,-0.08482994056881936,0.018199467174681544,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04555573580418021,0.08254398744303128,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011214556845138722,0.022884476521959192,0.6242539291345321,-0.056146235595765946,0.0337171219054885,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06343224632802866,0.08874164254165397,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16109575409273022,0.031845099336624084,5.418557151560242e-07,-0.22362083618503875,-0.0985706720004217,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.11758895182175351,-0.062327643068206894,4.675272464031e-05,0.0004468015431347066 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016720091693204014,0.02526837331193114,0.5083845039691816,-0.0663323443970475,0.03289216101063946,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03286236842066507,0.033294562627188905,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06930516814179988,0.031730921330390786,0.029287473606426827,-0.1316060716521103,-0.007004264631489461,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.12200406082373864,0.016152207570636293,0.4079068880915672,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06125168332140022,0.023536643702750413,0.009456492265782256,-0.1074638355943689,-0.015039531048431545,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07604250191989542,0.004468140848034989,0.19872601687461675,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12124437904284871,0.02300199933621957,1.8170586011710185e-07,-0.16640680361504412,-0.07608195447065332,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08186916324113888,-0.06098463950689406,1.7378085754331982e-05,0.000166077070192145 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049350700760612785,0.017759689199848938,0.005604575798069333,-0.08422030544975165,-0.01448109607147393,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.015049671989135028,0.013966985473020983,0.1422661633455176,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028521416150615646,0.020285186364383898,0.16016842816343613,-0.06834961480949718,0.011306782508265889,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04705007341583536,-0.05511718098867546,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06615068656362906,0.025442954350198548,0.009523206478246426,-0.11610571394793573,-0.01619565917932239,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.033247003047530574,-0.03391450700492332,0.1989347711166319,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06609624122360669,0.03027731897118307,0.029370520432277766,-0.12554312296189174,-0.0066493594853216445,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0758535269592861,-0.017374431479067073,0.4079068880915672,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012941162418128257,0.02803461678402319,0.6445040899130308,-0.06798469352219177,0.042102368685935254,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.016637569030313857,0.033187374434040684,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05138527530993591,0.02435604213316494,0.035239501388847606,-0.09920624511512235,-0.003564305504749475,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.027562325544925128,0.010745034803216565,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06298478621523278,0.026778048388352352,0.01894797313966801,-0.11556115459314452,-0.010408417837321035,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0432507097797554,-0.010437594903847418,0.3146632024742357,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041081451879592897,0.02572022022034199,0.11066996041533295,-0.00941796291920604,0.09158086667839183,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.013060051009377457,0.1801092244701467,0.7011158386088691,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08780924589694757,0.023590938457528403,0.0002136468127028766,-0.13412800119739593,-0.0414904905964992,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.01484297020310917,-0.03533659745188911,0.009474460330924216,0.09054453037322346 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010824407894298019,0.02394797639191802,0.651413569018172,-0.036195360328791955,0.05784417611738799,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.004397372584923853,0.08410851027649041,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10797423673159946,0.01914422822209483,2.4823200597073744e-08,-0.14556226333900094,-0.07038621012419799,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08307256287166138,0.0025286683388090103,3.1781704248317963e-06,3.037280631417158e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0979089645152247,0.020642956164238876,2.5608345574274315e-06,-0.13843961305091834,-0.057378315979531046,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.070290998619981,0.011779095266483913,0.00018822133997091622,0.001798773992251545 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0912228388390646,0.019959531676097327,5.769485914132587e-06,-0.13041164284875295,-0.05203403482937625,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03920551461425355,-0.01953835849635496,0.0003753949113638072,0.003587534779473621 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05850590692671805,0.03571693147156299,0.10186906808331146,-0.12863299457491054,0.011621180721474438,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09351531082597597,-0.03119428376306757,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006321980150504204,0.020197775497259974,0.7543725076921657,-0.03333459487533695,0.04597855517634536,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.005610278700474613,0.03522357516238987,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11105757968814503,0.026752642537183503,3.7207446097142155e-05,-0.16358406588754115,-0.058531093488748916,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.10766426238570026,-0.03651604993307709,0.001995626399453476,0.01907159340243874 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05802239101949407,0.01970794874635871,0.0033478524812840978,-0.09671723383381445,-0.01932754820517369,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05940865199328381,0.0020137549297892907,0.09525180285459917,0.9102924552359429 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10266542725394337,0.020197982999578583,4.792818163350111e-07,-0.14232240969253485,-0.06300844481535188,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08459989512024263,-0.006939004039194569,4.1808121517223276e-05,0.0003995474777817105 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08282549978712833,0.020391284399402142,5.429105070704491e-05,-0.12286201270746733,-0.042788986866789336,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05191309286476752,-0.047858316933198655,0.0028730824034168168,0.02745717305838057 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08644500897920875,0.01839778493476728,3.162443004739237e-06,-0.1225674591309032,-0.050322558827514303,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.041485094129264516,-0.05289940516294731,0.00022615741055513573,0.0021613174591382277 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09036070441133214,0.02151042576857678,3.009522618340767e-05,-0.13259455404715337,-0.048126854775510916,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06887089600604138,-0.013723023081771273,0.0016251422139040143,0.015530988933201399 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1182301825800469,0.01823187236109213,1.6950951996548615e-10,-0.15402687782736726,-0.08243348733272654,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04286526705446605,-0.09211520499039431,6.204534102939563e-08,5.929484180768225e-07 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09513984030208773,0.02014976699685108,2.83534249500728e-06,-0.13470215481401232,-0.05557752579016316,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04510928308650964,-0.02538842813150985,0.00020648576812264027,0.0019733215666538134 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0831364708282651,0.017520646531491855,2.535423545085604e-06,-0.11753673603428286,-0.04873620562224734,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03741912234471187,-0.04894011581162899,0.00018809525327934137,0.0017975690201606602 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.051251964687330204,0.01915283368111444,0.0076289366700712895,-0.08885688736486025,-0.013647042009800159,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03583403483822801,-0.006306209825881641,0.17308879679374334,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0841811911402577,0.01873326585919089,8.209469752824083e-06,-0.120962328900939,-0.0474000533795764,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04916199220497589,0.012482437224731814,0.0005171965944279173,0.004942690255428848 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1215864225195473,0.03111641696076506,0.00010246899295256123,-0.18268080016065613,-0.060492044878438456,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09145973014157104,-0.07835447332696104,0.004899993169020669,0.04682774161530534 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04982545207542778,0.024121995199780137,0.03924333925989927,-0.09718689108849299,-0.0024640130623625675,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06897034536078547,0.010171767694501238,0.47632053064997004,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07677970487520107,0.02416717037305842,0.0015543828642759175,-0.12422984141085527,-0.029329568339546863,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07092277650193954,-0.007200657773867176,0.051843240237908546,0.4954500495449042 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007042697016165885,0.019820968518382033,0.7224620015417398,-0.04595944432037696,0.0318740502880452,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.001108211694071465,0.031308932628697723,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1017889846554545,0.026491117113931314,0.00013310068919231678,-0.15380198843844428,-0.049775980872464695,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.085552463856703,-0.050216838261977696,0.006107244339934165,0.058365073188281984 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11065734569928026,0.020854597157625016,1.5111297491390826e-07,-0.15160353291317635,-0.06971115848538417,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.062437666804340014,-0.03646178494364962,1.4809071541563011e-05,0.00014152578417767157 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03845380184864164,0.021071528171080635,0.0684463179230215,-0.07982591423492622,0.0029183105376429444,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05194090360865803,0.008953859938268435,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08585843117314589,0.022024575296455667,0.00010633828041395571,-0.12910176867705417,-0.04261509366923761,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05328407013743585,0.013954898594990852,0.005054570478598685,0.048304989860929966 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08933706392504188,0.024052116667135408,0.00022025136016350314,-0.13656130251854123,-0.04211282533154254,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07924934632600152,-0.03428854160111991,0.009713084983210489,0.09282499346263162 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002295947339763185,0.021411911236175866,0.9146396535181596,-0.03974447758224129,0.044336372261767655,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.021145270634658923,0.10419902850731087,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018106689435633132,0.018729856292176366,0.334018881474608,-0.01866775393684014,0.0548811328081064,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.022391640412894164,0.045181945024078886,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11252459042525734,0.02566265795268636,1.3425714450823775e-05,-0.16291098671930793,-0.06213819413120675,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09024473388685865,-0.021252016685926817,0.0007894320097084379,0.007544361165072067 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05583522777736052,0.019262469393447234,0.00386681560966721,-0.09365541063798483,-0.018015044916736216,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.056858075501944376,-0.0007046870373286625,0.10548035157916945,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054402566374456535,0.019845789226148054,0.006279015075427912,-0.093368046979018,-0.015437085769895068,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0038235495300302383,0.010368346276613392,0.15242453109708493,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.069727811172912,0.020942189341746287,0.0009162379269117816,-0.11084597801999857,-0.028609644325825433,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05539729431539164,0.03538339407192185,0.03382835657593359,0.3232872957912386 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019203658580544646,0.01629404832033119,0.2389767413778222,-0.05119560491035476,0.012788287749265471,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03647431971916974,-0.004254797437533096,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08666736655711019,0.022068133331595286,9.456364735147727e-05,-0.12999622647355974,-0.04333850664066065,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.019782174664574468,-0.030268115385980735,0.004549371107127434,0.043476953409565144 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07102506416624972,0.02707040953089667,0.008890170157396475,0.01787467011974283,0.1241754582127566,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.05550010605350198,0.0020286762430066422,0.1944081837724882,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0908306176886351,0.02205022495577818,4.262887498446929e-05,-0.1341243160671579,-0.047536919310112266,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04131178563383514,-0.009289057838110189,0.002271060467293404,0.021703832859915062 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08341949719469736,0.027193005929918183,0.00224179570214308,0.030028395784334777,0.13681059860505995,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.05264838174602915,0.04747680733931384,0.06924270149265281,0.6617313988810555 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08756659365775425,0.021617691459533794,5.6872922544661954e-05,-0.13001105014588515,-0.04512213716962335,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02298955347537629,-0.007835589333541223,0.002989783173241898,0.028572446755133162 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09440147277674864,0.027923765552417292,0.0007638543571748171,0.03957558842212456,0.14922735713137272,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.04934779670059063,0.03154785625639507,0.029292154044703856,0.2799361904488662 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0448933814211912,0.0166134141214007,0.007057025212342059,-0.07751237471726347,-0.01227438812511894,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.027225149263588308,-0.02193531539151624,0.16360251162401113,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10564433712330226,0.01777711556303787,4.451219248264277e-09,-0.14054815696050646,-0.07074051728609806,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02763722597863447,-0.0748165761028773,7.361203831817048e-07,7.034878195204077e-06 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059038639385248656,0.017118428374145872,0.0005972852537668631,-0.09264918423143222,-0.025428094539065096,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03824474304038517,-0.003592225451848884,0.023706251722006796,0.22655342405862833 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08707235641218193,0.020399737373972097,2.2456340405553907e-05,-0.12712546601269842,-0.04701924681166544,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04653251326982971,-0.019887881598825503,0.0012553410573189218,0.011996911963647416 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016694067939084678,0.03201692154897123,0.602246022862148,-0.07955650799717388,0.04616837211900453,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03720298043456784,0.08797145882821494,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06896485927230218,0.025409817950717825,0.006811769731865177,-0.11885482621902393,-0.019074892325580427,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07624448354018751,0.01989197683094488,0.15903478862219345,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03265169781415509,0.016120515177938704,0.043203624665534165,-0.06430292691588774,-0.0010004687124224518,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.00773034767584567,0.009133456276967775,0.4971708399879019,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055585976214416535,0.019846461863637435,0.0052405240497306075,-0.09455277748417039,-0.016619174944662682,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05927182375956854,0.01989079646605857,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08036260689811982,0.022034713987572025,0.00028523167398541093,-0.12362585083999074,-0.037099362956248896,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03675355980559019,0.011422239342666151,0.01230526645704452,0.11759768193169373 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05448111896816991,0.021663998958765474,0.012135795711239268,-0.09701649620238938,-0.011945741733950438,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07466869165698396,0.02436577401089461,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06475981700426198,0.022135863925449653,0.003551429749778959,-0.10822166004932857,-0.02129797395919538,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04119942440202874,-0.027043909443033583,0.0996157220980402,0.9519971016942069 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09320713625596133,0.022020775789789844,2.621992247204308e-05,-0.13644301375908016,-0.049971258752842494,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07429800639982896,-0.01615752383346711,0.0014354051350557102,0.013717729486366907 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013223685063665045,0.023500172833776072,0.9551425638849877,-0.04481817638825822,0.04746291340099122,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.002997237762207727,0.030980051829111326,0.9948722834429907,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09819377032982055,0.029883307806256296,0.001068061798104813,-0.15686704542389582,-0.03952049523574527,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.10412535556576076,-0.0028556756980812705,0.038190425916018046,0.36497426328681687 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03970229812080323,0.02564725188106021,0.1220781669836748,-0.09005844593351098,0.010653849691904513,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.041113224927625945,0.07617731512361106,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08560740687408905,0.03588024283047875,0.01730554319951125,-0.15605514216777563,-0.015159671580402462,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08213331916201554,-0.0761454441341196,0.29669849226289485,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06408016669500198,0.030630860263845438,0.036802776248245246,-0.12422119600409748,-0.003939137385906476,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02400633599417384,0.02297782244899776,0.46006368166704054,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0904241622116837,0.024016678331812737,0.0001807192420928004,-0.13757882071683594,-0.043269503706531466,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08322579783922349,0.0009708326038443513,0.008104798552161861,0.07745509010997063 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08047823194524201,0.02048851555489579,9.429310669021328e-05,-0.12070564978049136,-0.04025081410999264,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03394089308109183,-0.008127489634332262,0.004549371107127434,0.043476953409565144 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03132303550455532,0.019102784070328265,0.10152183300407852,-0.006183619116404561,0.06882969012551521,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.06304617485410746,-0.007997464396095952,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15399701515320874,0.03004472796331413,3.857074476494543e-07,-0.21298722468246056,-0.09500680562395691,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05361022557839313,-0.0680704169489276,3.4792564993651915e-05,0.000332501941830682 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06299586876733859,0.020518220256602403,0.002222940325653151,-0.10328160920014373,-0.02271012833453346,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.024390903287788163,-0.030672915720640147,0.06892851681654183,0.6587288316682212 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09082087869646216,0.031611709167746214,0.0041908609164024255,-0.15288771949662172,-0.028754037896302598,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.1082945661099173,-0.007921276690453205,0.11353943329147595,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04984902906794816,0.020995638182554816,0.017857359681767982,0.008625920071868236,0.09107213806402809,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.020234282540563666,-0.009027504315454305,0.303536876132493,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08441331961593039,0.017627118014814286,2.0546975686952434e-06,-0.11902263231666169,-0.049804006915199095,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02663998848961669,-0.02037061142045156,0.00015835135243012468,0.001513315623155056 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014301311475916395,0.019594692405368316,0.46572603124489564,-0.05277378531776022,0.02417116236592743,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04833735212965087,0.043134571547933875,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0984568953765324,0.02058500542691561,2.1138564535698945e-06,-0.13887376268108134,-0.05804002807198347,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03698237019874363,-0.05273930882453895,0.00015979389461704454,0.0015271015592713227 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02036671124568186,0.01871745866047823,0.27692566781835026,-0.01638339045551942,0.05711681294688314,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03128770906209728,0.07616693773568062,0.8725380346331878,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10241837035144587,0.01820397425055315,2.6810191209719886e-08,-0.13816029008579855,-0.06667645061709318,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0315253161054004,-0.025230998063695186,3.3253015284805694e-06,3.1778893438700457e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06639502232978146,0.019528327999977824,0.0007128855687602605,-0.1047371954352016,-0.028052849224361333,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05956674392313225,0.014614144151333037,0.027604320218629012,0.26380607688121777 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07483101243346907,0.02976531968432637,0.012162736028722207,-0.13327262811484777,-0.016389396752090356,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09069395795673017,0.005804843534588148,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07887545473595832,0.023882956069593123,0.0010074702130506998,-0.12576756121279156,-0.031983348259125084,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.050324172167545214,-0.02407206556808739,0.03644649474155011,0.34830804445427466 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05139529783549876,0.017055012484378844,0.0026772520215340074,-0.08488133109917079,-0.01790926457182674,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.025447136753611734,-0.0063369745065469905,0.07911164839882295,0.7560459172479591 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07167784727771037,0.031510790481380224,0.023229954267981218,-0.13354654301689897,-0.009809151538521764,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.060529022161593116,-0.029380895872191126,0.36015503316256814,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058915180421038826,0.022703058484030727,0.009659473033252113,-0.10349066063717263,-0.01433970020490502,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.042294117615348785,0.025165385426642452,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0024740401551894835,0.024190107495872717,0.9185682573118553,-0.049969211736009204,0.04502113142563024,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.006028236679861299,0.007839701234488641,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11562947509366903,0.025890456962208493,9.307165099477486e-06,-0.16646313492489243,-0.06479581526244563,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.07260896223548238,-0.013345966989155113,0.0005639715767912388,0.005389704508840115 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05951524097941378,0.030465236598086306,0.05115925256287308,-0.11933108262969394,0.00030060067086638137,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.006818476479368623,-0.12531670680786208,0.5315473126231498,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05241726860174421,0.030277581849342705,0.08385951958026047,-0.11186466647842587,0.007030129274937444,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02566144183169831,-0.041563830015590886,0.6500804664849935,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044438881509493725,0.026272124714581575,0.0911965771886284,-0.09602191276822808,0.007144149749240623,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.04872165640263467,0.00940849315644027,0.66475521554025,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08274656862651696,0.028218751900367215,0.003475918450844449,-0.13815163301216288,-0.027341504240871048,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0900870561180848,-0.02854528563335323,0.09854228808144014,0.9417386198889203 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007175046183237898,0.025438285256754005,0.7779845114402947,-0.057120906208767294,0.042770813842291505,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.011362524595874003,-0.04597292850383239,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24302067505320735,0.06267512530377488,0.00011565239629370065,0.1199635191203511,0.3660778309860636,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0791995863400633,0.7118341552540602,0.005436114064320203,0.05195128564764741 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07700214270336321,0.022514043818803703,0.0006626973797252035,-0.12120650906819311,-0.032797776338533306,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.08328733451466624,0.013709147984518597,0.02604203861514191,0.24887582764720492 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07640796791636882,0.021642058137610356,0.00044233551747731265,-0.11890026625705447,-0.03391566957568318,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0822094881920493,0.023731049857769457,0.018006458142230296,0.17208223362884745 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007861898073772375,0.026141649074231266,0.9760165668623757,-0.05211304349738384,0.05054066388262937,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.030953433986626963,-0.007766025772292216,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06672106795817245,0.02052282711925969,0.0012057045224398832,-0.10701585356501803,-0.02642628235132688,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06336170885454687,0.012253314922617456,0.04234903760676014,0.40471684802421154 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03126302958668392,0.023687561265680786,0.187337515974149,-0.07777149536496299,0.015245436191595144,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.0018588704966681668,-0.02893547230556922,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011220973498920626,0.025784024856455184,0.6635601375262515,-0.0618456631498617,0.03940371615202044,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.019977946099134475,-0.008686388567308191,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08088573259543838,0.020534075887971532,9.011672082804851e-05,-0.12120260418103097,-0.04056886100984579,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06423449499247359,-0.017675919191980905,0.004415719320574377,0.04219968401117099 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11416178475898245,0.019422408091212606,6.475388923994018e-09,-0.15229599333834634,-0.07602757617961856,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06373993438068684,-0.060814654478495565,1.0280327455732904e-06,9.824595692528385e-06 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09110291704284254,0.02156825299354676,2.7233175128585185e-05,-0.13345030540404812,-0.04875552868163697,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06880062805151743,-0.009971811124793072,0.0014806640011692412,0.014150254678762169 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06589360591127065,0.026510231575129203,0.013169688302419007,0.013843072546635804,0.1179441392759055,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.02152590686068659,0.05875031173802237,0.2450248350502534,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10449933078581623,0.036505013181639775,0.004329353271158797,-0.17617374831033064,-0.032824913261301825,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0729012885523727,-0.008069039493404115,0.11689253832128753,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0352525791432749,0.026925208071945185,0.19087669306954502,-0.0881178827573452,0.017612724470795392,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.007952284993791652,-0.0026637965610030933,0.8119931348263925,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015510865170294324,0.027950122688604768,0.5791103248428537,-0.07038849946880835,0.039366769128219695,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0382036195248297,0.02697816676621987,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10327768449041065,0.03287697744222214,0.0017537720279328947,-0.16782876947188502,-0.03872659950893627,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.059743498300584924,-0.04293465610505765,0.057765320986437003,0.5520455707122307 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07879253534759546,0.019609200780580958,6.511900058288584e-05,-0.11729349512197187,-0.04029157557321906,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05792018241060499,0.014166023032618926,0.0033565884845905706,0.03207789334464142 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05432151877732037,0.03283504423923802,0.09850652554766995,-0.010147234008193166,0.1187902715628339,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.06047822902467577,-0.030097385524673708,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11885804773088685,0.029792292949754676,7.328408481132888e-05,-0.17735262307231797,-0.06036347238945573,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.09190298800574052,-0.050146267405950254,0.0037290324694380043,0.035637227018589394 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08872328376656621,0.01798318466876271,1.0127179423210421e-06,-0.12403170236529214,-0.05341486516784029,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.031210045770499874,-0.04816990055573497,8.373911485567118e-05,0.0008002692041179875 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06317332190729279,0.02024558553050071,0.001881774366716268,-0.10292376777403206,-0.023422876040553514,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.0526672706404868,0.04973673132754674,0.061219364438498916,0.5850548114850131 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06376131963905293,0.020960118042806127,0.0024391389367877684,-0.10491468793091208,-0.022607951347193796,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.008820580883062415,-0.03159784034100728,0.074183466974028,0.708948789061601 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03984289534742638,0.025905909801252684,0.12451142299393221,-0.09070689548374929,0.011021104788896521,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.05380950374736056,0.0886360392697917,0.7259506085296737,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021500577511007927,0.022479682493330478,0.3391829764252574,-0.06563747840263257,0.022636323380616715,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.013461616876632653,-0.028099127131980664,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08661689794600387,0.018769954921820632,4.696046997305545e-06,-0.12347007148928912,-0.049763724402718625,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.049299059442273516,0.014423988796564929,0.00031325395852614636,0.0029936726284795524 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05094213541427029,0.018701130837889355,0.0066128368050824655,-0.08766017885630376,-0.01422409197223682,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.01655607782194262,-0.014365477594647038,0.1564101093868082,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11138126671471574,0.020156095834788786,4.651043889306511e-08,-0.1509560073493357,-0.07180652608009577,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.057647167209374114,-0.052172182096755164,5.274283770473584e-06,5.0404722841460266e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018197213780818417,0.015826070314246786,0.2506148380117972,-0.049270326008761856,0.012875898447125018,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.018738651138616502,0.019804274894825648,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10112014465293015,0.019701382948114746,3.720444534371902e-07,-0.13980209609360883,-0.06243819321225147,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.060205088344584365,-0.028381696148691474,3.3945849096372593e-05,0.0003244101360073502 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012302593873291646,0.016024975414128572,0.4429202821628613,-0.043766238960537066,0.01916105121395377,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.009924540291475143,0.05083482989359828,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03066313814240411,0.01708322380404301,0.07310353010468774,-0.06420456187791258,0.0028782855931043655,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03815962390159323,0.05782815382794737,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1729792225748024,0.029513535952365364,7.132395556808403e-09,-0.23092648280311884,-0.11503196234648594,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.030612480659556532,-0.14009674149187656,1.102272258046489e-06,1.053408009134766e-05 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10711371714901644,0.023086468024452116,4.177093029544343e-06,-0.15244198864196223,-0.06178544565607065,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.042186902662410306,-0.011049904440459236,0.0002833996963121624,0.0027083645415396217 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017205712548321768,0.016637663115283995,0.3014324390658877,-0.049872316634273564,0.015460891537630028,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.027342862153138154,0.02196243492961507,0.8896367821404172,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10305553864060928,0.02154351996445134,2.1071920174375705e-06,-0.14535436585090633,-0.06075671143031222,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.06047387915896961,-0.019639857361547594,0.00015979389461704454,0.0015271015592713227 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018307835686731583,0.018775328091870762,0.3298525276435518,-0.01855588760849286,0.055171558981956026,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.00499744649702022,0.058054331779730205,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08259330155002541,0.017776482445645454,4.050865652557982e-06,-0.11749587831630945,-0.04769072478374136,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.02860637744163155,-0.02841020103288675,0.00027720492715521775,0.0026491630203452883 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056343650682681046,0.016868228334200788,0.0008822425774889652,-0.0894629495172978,-0.02322435184806429,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.03536873530314591,-0.030914451708894886,0.03287906845120848,0.3142152384454954 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0017063085781817999,0.027279662436187912,0.9501439874713483,-0.05526755249967532,0.051854935343311724,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,0.043884327608139956,0.19313791762856516,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008530678414478745,0.023824793453214466,0.7204089318557032,-0.05530858765407502,0.03824723082511754,549,153,702,11,log_other_mut_burden|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Myeloid|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Uterus,False,689,-0.011100700826474089,-0.04312379954641646,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07608516512806703,0.0773842189135222,0.32724855047007895,-0.2291171611748719,0.07694683091873787,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15483787612709404,-0.029534002802257826,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028350020045819962,0.06789868246883092,0.6769461581923253,-0.10592375118349354,0.16262379127513346,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2262932635370521,0.08666385536206861,0.9619695749374265,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0014671163872300066,0.04934981526189392,0.9763268346558014,-0.09612514260433863,0.09905937537879864,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.19550640394468383,0.09014189272637055,0.9980529036429133,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07386483102524237,0.08203119724599182,0.36947358277892506,-0.08835684710130005,0.2360865091517848,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03963477255021657,-0.044551549785885824,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019692248336159582,0.05797919794900241,0.7346490848383616,-0.09496513938321476,0.1343496360555339,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10659767970931867,-0.003485721799099341,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05486328111293757,0.05937129871561408,0.3570861222653867,-0.1722736327053587,0.06254707047948357,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.25043642397627086,0.08352184884755817,0.911668967477982,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019647339973278766,0.07496322317555017,0.7936462632942575,-0.12859698986193466,0.1678916698084922,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11910659412861593,0.018444750723830713,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001267876646221512,0.04346929797383569,0.9767740181342821,-0.08469530201069966,0.08723105530314268,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.144394416855315,0.09026016628226291,0.9980529036429133,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014324638082204164,0.04157210487004909,0.7309474288120663,-0.0678867259071406,0.09653600207154892,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07755737718919994,0.018351597576542998,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023585902561783115,0.07186664180777756,0.7432728571634194,-0.1185347494191491,0.16570655454271532,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06567580400478254,-0.037017903134065805,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02503429321671365,0.04831714905099781,0.6052133664850761,-0.07051580558092548,0.12058439201435277,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09806511345580601,-0.006257385520638368,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04346263750153447,0.08009013033719764,0.5882441486575816,-0.11492046284153082,0.20184573784459978,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.025761744360538526,-0.10646411429239995,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017770268525869968,0.0488878423082517,0.716802878391567,-0.07890841087275206,0.11444894792449199,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09008699357116372,0.013480355420789545,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013594698659779863,0.041606092808232006,0.7443609835716987,-0.06868387854299102,0.09587327586255073,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.091140467491578,-0.0006820531793783069,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08989256108803367,0.12025638625127641,0.45604774355795064,-0.32770687366737283,0.14792175149130546,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.17462607316985845,-0.016672775940463798,0.9351865121061772,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025756300002480813,0.09574789444534593,0.7883364074147395,-0.21510358049418427,0.16359098048922266,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.44151513666382747,0.34341627433213534,0.9726336318937702,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01020047705774096,0.03607550131278422,0.7777956390805694,-0.061141019332549604,0.08154197344803153,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03969234820653993,0.0020292387643376982,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03692799553392119,0.055294152601991366,0.5053634592929565,-0.0724195518239646,0.146275542891807,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10269157904171884,0.025137759389116603,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008338603954791935,0.0450107484060219,0.8533026307093138,-0.09735009452538995,0.08067288661580607,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06447717099086839,-0.01942010755921984,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03573707023614447,0.045453053325092814,0.43309390246905244,-0.05414910519368025,0.1256232456659692,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08525515120759673,0.0336335824906777,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034029666319734815,0.06378235003835131,0.5945390525263766,-0.16016313999131956,0.09210380735184995,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15715908660620612,-0.05618829872586521,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015641390151843272,0.08303402723669018,0.8508648547243265,-0.14856344522984527,0.1798462255335318,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.19774768754331862,0.09838831185500298,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019275578987728505,0.042286887509194224,0.6492401278103185,-0.10290046908800063,0.06434931111254363,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.22777927644759055,0.08337169011371875,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09064350269814367,0.09651374190394461,0.34930481170917294,-0.10021828768849975,0.2815052930847871,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.162275663297333,0.010644228735379312,0.9086977961712401,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07514920861368608,0.050581300639473324,0.1396699153055878,-0.024878387557469933,0.1751768047848421,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14644275849107746,0.09242158706336714,0.7562754349902838,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003915396746684489,0.04939166942780112,0.9369324733934223,-0.10159042489508614,0.09375963140171716,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05975228610126056,-0.0014492733953949777,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02685702922957435,0.04571849872624713,0.5578800219345643,-0.06355408061388688,0.11726813907303558,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.18927602566933946,0.1045227002911872,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020584394292939377,0.04336869785074282,0.6358068964279546,-0.10634863009231668,0.06517984150643794,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.037648804635605895,-0.022854578211249737,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01910238788891367,0.04907592436559273,0.6977062820413372,-0.07794823520907751,0.11615301098690484,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11626642450218211,0.04527217118028032,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02375119814037153,0.04038572546459776,0.5574346472334378,-0.05611402847065418,0.10361642475139725,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03514471105039977,-0.027598749130880854,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02962886346321181,0.038102840180656045,0.4381539792755783,-0.045721818752943344,0.10497954567936696,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03986086609017491,-0.031161598283463092,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010473115483377963,0.07701993814554393,0.8920387336871483,-0.16278472417178005,0.14183849320502415,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2055654255412462,0.07473435660441222,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0547117494182232,0.08719786598463247,0.5314204804174615,-0.11772733015124628,0.2271508289876927,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15919913650645598,0.022287279473194768,0.9462574637850627,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01240554809018327,0.04498762264712182,0.7831550409813428,-0.07656020988668616,0.10137130606705269,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10015808175464054,0.024721378161409454,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007930102511179704,0.06372351188890411,0.9011463204672487,-0.11808701514389391,0.13394722016625332,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1023703560067122,-0.011161211890442805,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09644973209520623,0.041741868194676394,0.02235820929954375,0.013902650813782946,0.1789968133766295,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07053859939104387,0.1786579128778234,0.34868264326086107,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036060566880842734,0.061359321548836755,0.5577115674766369,-0.15740235445111708,0.08528122068943161,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.16036966468582875,-0.008623443013991525,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049577177198753125,0.04135993752577253,0.23273834467407417,-0.032214612972487,0.13136896736999326,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.047034152843366615,0.10311665601486908,0.8439821745193242,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017312356932089396,0.048668811176737395,0.7226031477124196,-0.11355788895618688,0.07893317509200809,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08426296745431158,-0.017806042535800447,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015781990083712467,0.03871910440163194,0.6842066879985895,-0.06078739208383151,0.09235137225125643,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07543718978129661,0.0049749759222231845,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02691323963327111,0.04662203366097784,0.5647152589598801,-0.11911114472389221,0.06528466545735,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.13201668642205497,0.010217224410534085,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04187498331670684,0.04895314600167172,0.3938290126618351,-0.05493283810458601,0.13868280473799968,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.039290538216520454,-0.019709529276006842,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0051670607614215215,0.04415504666554275,0.9070161728321436,-0.09248634913362831,0.08215222761078526,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09147348291778666,0.024306664457519778,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022959462865400678,0.03613781811510717,0.5262803280037902,-0.04850526878888335,0.09442419451968471,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.013659273061574485,-0.03511656150442312,0.9448126253726593,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019008870989658384,0.040272414495876825,0.6376780716680258,-0.09865001827338947,0.06063227629407271,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.009919271925759143,-0.036906703651738856,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021912227770123444,0.036697645567006616,0.5514322416762016,-0.05065959669466899,0.09448405223491588,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04583936531381047,0.036396388780527617,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0417758354104828,0.041827222573153806,0.31967916457015905,-0.040940039341923626,0.12449171016288922,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04602397290742257,0.014832057923457006,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004452965205470151,0.03777246053821485,0.9063293837528378,-0.07915030159936526,0.07024437118842497,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.03691352721148126,-0.012915337676765991,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026981572683384858,0.035018536560830524,0.44234331786539505,-0.09623285703802321,0.0422697116712535,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.027400923332464685,-0.03188418893967874,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01568309013020682,0.04614735993890041,0.7344952555122579,-0.07557611882597823,0.10694229908639188,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10796202013021118,0.02249180102496242,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.245307753430527,0.0957053263802637,0.011459905409079079,0.05604465387466348,0.43457085298639053,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1299618365084106,0.6191679563115371,0.22274190244438216,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10844821394461417,0.07957283309367681,0.17517270769124949,-0.26580832754907885,0.0489118996598505,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14679504794360826,-0.21057102977799463,0.7896200758961603,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014790568884537997,0.09663535916038052,0.8785813993482575,-0.20589286478725985,0.17631172701818384,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20802890553937559,-0.024863781103340206,0.986191362849829,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018671402385732283,0.049924767314246395,0.7089935975951782,-0.11740066400442611,0.08005785923296155,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12164482350720185,0.01337167413251599,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030593903867633648,0.05529884669287919,0.5810028284052396,-0.07876292634027343,0.13995073407554073,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0019104256646341369,-0.05960679864029339,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09253354734573213,0.05928888373847035,0.12091304646762904,-0.024713823620489864,0.2097809183119541,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.009255211595810714,-0.015329736878979,0.7228579124835106,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021312832010322004,0.062299887004846434,0.7328032341194124,-0.14451464493417246,0.10188898091352844,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10522396425101829,-0.09998827937018268,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1318731435255892,0.08226686443886339,0.11125637190302612,-0.03081458079789401,0.2945608678490724,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.004075496692750884,0.07068998275869703,0.7037076335985827,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04256211998057792,0.05557512612855259,0.44509366875365375,-0.06734106960268232,0.15246530956383816,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07842563890689007,-0.05688379292987726,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08226106068157926,0.04176960280608499,0.05093953962980535,-0.0003408674795183225,0.16486298884267686,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.010358947256213778,0.013960244206221276,0.5306536293719093,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029553837067733717,0.04831509464649942,0.5417643897517253,-0.12509987315561766,0.06599219902015023,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11677711115075096,0.009237778046731197,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029350124171495226,0.045743585761044536,0.5221980903849454,-0.06111059680798113,0.11981084515097158,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.13495320847916925,0.01913134433415208,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011279410375934674,0.056478135182812764,0.8420034517065811,-0.1229683552457631,0.10040953449389375,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.16666696267420253,0.010139588049369853,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07351721227991885,0.07041648086211938,0.29832178862237174,-0.0657356582952051,0.21277008285504279,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15730616284697546,0.15938527530746538,0.8855940007795015,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03773438225510257,0.0614565527927254,0.5402404025906158,-0.15926845051954558,0.08379968600934046,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2095611859885116,0.09152315032484307,0.9481163084809376,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00732690614823233,0.0410674692806092,0.8586653591969056,-0.08854032258945307,0.0738865102929884,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.16755633186629945,0.10717526810786077,0.9839047884462332,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01942865060369823,0.06092833592499184,0.750308936974664,-0.13991813790900293,0.10106083670160645,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.143727835034077,0.04929479722369,0.9646550643928868,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013887857360475587,0.05286234606427957,0.7931659770314565,-0.11842635949324148,0.09065064477229032,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12684321945407792,0.011271076909383152,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020701529398312435,0.04606228921329607,0.6538407524914341,-0.11179250582431029,0.07038944702768542,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.18020121811872233,0.10257904594027305,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0006579338097053133,0.04476014075377647,0.9882937784271687,-0.08917383251692121,0.08785796489751058,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.17790978381756,0.11777521674418262,0.9990191441902606,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010620972345686094,0.03786619915547683,0.7795302027844466,-0.08550368255232589,0.0642617378609537,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0421880131622582,-0.06552504807543086,0.9705004312583027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03839967308774417,0.03891959204574725,0.3255706351776855,-0.038566185580983764,0.1153655317564721,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0472511787244937,-0.025571364104744074,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010510823440953367,0.03817158868762904,0.7834597036936217,-0.06497581312603748,0.08599746000794423,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08399668663547025,0.06105435115705697,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10570873995905425,0.08039375993652924,0.19076062608528616,-0.05327480637024673,0.2646922862883552,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12467320702590319,-0.0145861226504242,0.8119345039490624,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03587642335359045,0.055618122525327066,0.5199819980316411,-0.07411179421746368,0.14586464092464457,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20628447580171302,0.15600122614720832,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051617198059971454,0.06850417905587998,0.45245812418993503,-0.08385397947022097,0.18708837559016386,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.020407255621214367,-0.13723486799403006,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017650360929427227,0.03898384997270989,0.6514424049568779,-0.059442571695243994,0.09474329355409844,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04813471642764526,-0.0006634934667808174,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011214205159931594,0.03975800000137615,0.7783250489963313,-0.06740965619658973,0.0898380665164529,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.06962886667030342,-0.10931543604493507,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036793136083430336,0.03949027971811779,0.35314204608235855,-0.04130129214183424,0.11488756430869491,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07271554204943938,0.020420436523007485,0.9092831415853414,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003437587629894139,0.03667587998846278,0.9925353652441629,-0.07218502294739597,0.07287254047337478,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06255193690848322,-0.029614278996706173,0.9994603233931454,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026572378324094433,0.04397741097621736,0.5466987814627999,-0.06039562467638828,0.11354038132457714,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.006394684750985092,-0.05473548336928266,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003795882383966011,0.03183173459488839,0.9052545552446587,-0.06674507216814682,0.059153307400214794,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.01758294457765675,0.02612648431658222,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03102307442571409,0.03674515100001356,0.39999748474535746,-0.04164269492006559,0.10368884377149376,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.002739465560412316,0.022747911349016665,0.9216778037470674,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01035442219301468,0.03545936638120314,0.7707253980436903,-0.059768629923523095,0.08047747430955245,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0027978557405014676,0.02685987158340318,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017182736200030232,0.04396512693237351,0.6965370476698387,-0.06976097435716955,0.10412644675723001,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0932190160770834,0.026751642984249403,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03151988370640808,0.03448954865936339,0.3623885185074228,-0.03668529492302304,0.0997250623358392,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,3.8899086804058775e-05,-0.013808600856530557,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011493934206882092,0.05927122542773844,0.8465271013655479,-0.10571851637665647,0.12870638479042065,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04284249073785966,-0.04587701711069448,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020567399898517972,0.05610468706071736,0.7144948077082645,-0.09038302861298093,0.13151782841001688,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14149624481988773,0.06487366986847232,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028845325771819065,0.04920287982868692,0.5586773973279947,-0.06845635947035505,0.12614701101399317,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06048532593417861,-0.028968393081141873,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01327576236443573,0.04829028472591817,0.7837981270654244,-0.10877273532650905,0.0822212105976376,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1298104277922723,0.012790371679023504,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05916290457530349,0.052639262354176666,0.26302219450962283,-0.044934435962477204,0.16326024511308418,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04175989673674668,-0.00556970304588506,0.8670850705749964,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013651390943243327,0.04204995170861938,0.7459470700155892,-0.09680772609773981,0.06950494421125315,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.016603690482412888,-0.021759180272527493,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013131572725131577,0.052223421026730464,0.8018458590078554,-0.0901434163142259,0.11640656176448905,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09313476650550058,-0.02448725342283288,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013530100903551008,0.04188159003233686,0.747148968854285,-0.06929328880365612,0.09635349061075812,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.061689246771232706,0.025889255231153853,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05311465040943431,0.061012974251939335,0.3855356584692172,-0.06754221433143398,0.1737715151503026,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05603338264065571,-0.03249698264829012,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0032430497472019145,0.03913784182978694,0.9340829041047987,-0.07415441113393191,0.08064051062833573,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09715624716907476,0.04200256134843722,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04236425774923798,0.045560278401097346,0.354095918140621,-0.13246247728363109,0.04773396178515514,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20623937001182271,0.03349242128985401,0.9094475823584263,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00976102485733223,0.049012535230825514,0.8424399986749472,-0.0871642423740843,0.10668629208874875,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05953328343655221,-0.03539560582477061,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04161052564467899,0.04800902401176823,0.38762036932576016,-0.053330237161108913,0.1365512884504669,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04751943365220726,0.029065612275265246,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004017538413140576,0.04227125625157977,0.9244214780465295,-0.07957643992518518,0.08761151675146633,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.104210090772598,0.0658606955318595,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01649049878191307,0.039952543663858905,0.6804381755513986,-0.06251808449085919,0.09549908205468532,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.04084332744142723,-0.04828816124484183,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011429239897993777,0.04703069148341543,0.8083586626970675,-0.10443529066929497,0.0815768108733074,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04592160398283654,-0.06232601399189944,0.974516576191754,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02161472519746724,0.053512260974306454,0.6869052576296464,-0.12743847356439283,0.08420902316945836,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14407606444344967,0.08718320613779777,0.9631430579652833,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04016444942515399,0.0718662421725923,0.5771641860203278,-0.18228431110321888,0.10195541225291091,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.33898913720574825,0.08851474618882631,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002965445043088803,0.04987945109607461,0.9526791770329794,-0.10160509108618486,0.09567420100000724,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1063963910750876,0.09293143362368585,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024613191439886845,0.0678073822142613,0.7171782145787875,-0.1587064108668751,0.1094800279871014,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.316404479157842,0.10607963859654701,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0005194344188526497,0.05530918205751359,0.9925205650423697,-0.10885783460076669,0.10989670343847198,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10377870647318183,0.11495266233873666,0.9994603233931454,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0025156183835080568,0.07045612302994772,0.971570134451007,-0.14184688375482649,0.13681564698781037,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.373175646763637,0.16552731200829693,0.9975397208522654,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005180044473250151,0.030678289192227908,0.8661651060580093,-0.05548813692474535,0.06584822587124566,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06158861116027444,0.025097963224829174,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026661251427205067,0.03639741693479523,0.4651215842032911,-0.04531685267053095,0.09863935552494107,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09625542526984324,0.0703867477616072,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02729355305359115,0.038232513433872656,0.4765227097719874,-0.04831356590189192,0.10290067200907421,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05460420714763977,0.01856677758139349,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0055401336234476165,0.04163939201286016,0.8943502644444603,-0.07680429478028598,0.08788456202718122,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.033822421202113824,0.004349343243818076,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036518951401919776,0.07221669064853226,0.6138958996194916,-0.17933184624020282,0.10629394343636328,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.09249917128522461,-0.02462430480126577,0.9556150025445134,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06462635317606075,0.057222555913460524,0.26072313346593506,-0.048534728931942245,0.17778743528406374,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06570288107811256,0.06667775100412221,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007918814762865212,0.036837653989763075,0.8301164431973673,-0.06492988486715606,0.08076751439288649,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12182105899280732,0.07703131141412284,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013950879358090024,0.04289522954954435,0.7455056767313952,-0.09877880281608076,0.0708770440999007,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05437186805707369,-0.010410922505364371,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041017319882733654,0.04337438031741815,0.34600026938386574,-0.04475815333985481,0.12679279310532213,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11805993870409139,0.10634260798256603,0.9073781709238445,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006946747032003947,0.05095289044891022,0.8917567499605119,-0.0938156905712576,0.10770918463526549,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07196652063609177,-0.029459171598424275,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05602323615449274,0.048350811410540775,0.24861616583196333,-0.03959343200502444,0.15163990431400992,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12691555953030956,0.08975564999818031,0.8577318021260126,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002999214068663004,0.04980515937416233,0.9520696590556011,-0.10149194371648347,0.09549351557915746,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05680129365338101,-0.02646827570011452,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0871815350670908,0.06479414579466383,0.18069780001454275,-0.21531589634023196,0.040952826206050355,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.20535959230905168,-0.006617245979924941,0.8014130815101496,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09092366194191437,0.06498214221441469,0.16402664398451075,-0.03758247367705661,0.21942979756088535,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.028518571085031082,-0.035937436749808246,0.7824698350312412,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03559183082278352,0.060688423903613016,0.5585330896664668,-0.08442321587922125,0.15560687752478827,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12106250533290777,0.1221571629682564,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07014772940827013,0.08854282721868774,0.42959681482884804,-0.10495109274363804,0.2452465515601783,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.14638053360675415,-0.04209374749140571,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05716704448971732,0.07025697188963573,0.41724774660191366,-0.19610447637735093,0.08177038739791628,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1703142605892283,0.05530319740095946,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06222055441040693,0.060465300918104814,0.3052926354775653,-0.057353253027111625,0.18179436184792547,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.021159725242258058,-0.02777049100989552,0.8935888423380949,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021674909808074037,0.04387627911614635,0.6221026512434757,-0.06509309879267339,0.10844291840882148,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.11724485574240735,0.08815729621076193,0.9582992440631078,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0012934572189183169,0.04644112697973274,0.9778213812935881,-0.09313360835249451,0.09054669391465789,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.22390315777475017,0.09902046338332254,0.9983210449785855,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04095424490248761,0.0380228491149904,0.2833444106782757,-0.03423825011973328,0.1161467399247085,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.009525051232030053,-0.028035321006461743,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10208189985612817,0.05151843480312036,0.04955589177786272,0.000201063920585276,0.20396273579167107,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1546939280013098,0.20613419338853045,0.5240813480471289,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053944263889884644,0.0814888863203979,0.5091022029627972,-0.10720496142151244,0.21509348920128174,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07203499373956179,-0.0425455116834586,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0050006094017476565,0.03923692866200233,0.8987752598032897,-0.07259280171224723,0.08259402051574254,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.10599205149806644,0.08001309727116235,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03097459077674873,0.03393755444472155,0.36301876804973043,-0.09808816729842545,0.03613898574492799,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07050941782428813,-0.024490102291394367,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0913405685488855,0.051439028635987524,0.07801791015875861,-0.010383236865119883,0.1930643739628909,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.026931797280247218,0.04918910968020761,0.6337247675321748,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026125303262617038,0.035910419085110376,0.4681622222857237,-0.09714033951455547,0.04488973298932139,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07840943861735601,-0.02616877799484889,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07135513289275278,0.05092259270725073,0.16341804388949152,-0.02934738908498513,0.17205765487049068,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04930067107132913,0.056057319167276826,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0097715691356163,0.03737057387100612,0.7941197709115091,-0.06413101194859121,0.08367415021982381,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04677376569873683,-0.03002971003135107,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021897961602533822,0.036478665488518025,0.5493086179380822,-0.05024081644819525,0.0940367396532629,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0348109895364136,-0.01409243938608555,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008725512076804054,0.06797137119592117,0.8980454901000967,-0.12569200552809998,0.14314302968170808,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0548183970291082,-0.06088832290457673,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-9.952492291220543e-05,0.048659073042018525,0.9983710436509459,-0.09632579919375296,0.09612674934792854,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12986463031180626,0.00833704746014546,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021382947176245455,0.036737685665558906,0.5615006998148554,-0.05126805901693291,0.09403395336942383,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0957188478807265,0.06577304569525308,0.9509691818071948,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012821751421363931,0.06650185937689988,0.8474009520714035,-0.11868971724957711,0.14433322009230498,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.165844769099634,0.08786086780204189,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007518481552271457,0.05051139736901692,0.8818946668618299,-0.1074078397576208,0.09237087665307789,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.0797889302657172,0.029282695130189645,0.9868170095220195,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022728464590122528,0.06175732025134451,0.7134240296715584,-0.14485731878359126,0.0994003896033462,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2071326390388155,0.012235905848798958,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010538737311323565,0.05719282217718024,0.854078647221397,-0.10256354452607146,0.1236410191487186,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07515448009326908,0.01052721929094612,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041342644454007434,0.05918354552521497,0.48602631595428214,-0.0756964137934096,0.15838170270142446,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.354493931740326,0.25689786642612306,0.9400644974323602,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058159255157754344,0.06080202803066261,0.34049936254440005,-0.06208045060995712,0.1783989609254658,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2488401366160011,0.1873112226088845,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06007003846987029,0.060837847721646764,0.325210069277482,-0.06024050291375933,0.18038057985349992,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.06311509269561688,0.10346538979294292,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0681505714555852,0.06141418611639708,0.26909188651220317,-0.05329971413151845,0.18960085704268886,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05125450884855854,0.02833160409970641,0.870012817074135,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04670051683753019,0.051186828296659395,0.3631967439581705,-0.05452454707758903,0.14792558075264942,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.19594237222228084,0.1522530463696664,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12386204272569075,0.1491507047208504,0.40774047260273383,-0.4188166261754038,0.1710925407240223,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.39676914210931485,-0.5006077092506059,0.9246299615143487,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04246132761972055,0.046326629075270374,0.3609935149020487,-0.0491523969489945,0.1340750521884356,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0025045885876145532,-0.021822036360011503,0.9134053709502656,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04289518021068969,0.044265173208330066,0.3342402938479174,-0.04464189009298959,0.13043225051436896,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.010942534652255791,-0.021576180434742263,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04165678252238334,0.05464147622681688,0.44716201367121877,-0.14971362268094773,0.06640005763618106,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.26390495412197335,0.16670880213130693,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04725887397489545,0.04329839112917502,0.27699620147085324,-0.03836632600958205,0.13288407395937296,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.030064497260162068,0.05073686735989715,0.8725380346331878,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03784902836923611,0.0534268412315806,0.47989247938368973,-0.14350385400340465,0.06780579726493244,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1967198148657398,0.08251369129199665,0.9385036958235352,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029313038486261392,0.05740553623273078,0.6104374138123985,-0.14283597529653258,0.08420989832400978,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2345543080770813,0.1343739546079693,0.9549530254352627,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05943638837327881,0.03825579154116353,0.12259021989050285,-0.016216764454134842,0.13508954120069247,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.022020899381726643,-0.025067422292879074,0.7228579124835106,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028359868077973867,0.03630103660311235,0.43601844263802003,-0.043427638056195865,0.10014737421214359,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.0034985812490597994,-0.005656040441475124,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03467567561878269,0.05440772021594483,0.5249813376291264,-0.14227024905896535,0.07291889782139999,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05412865816992546,-0.06799507288140327,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04643212434774554,0.05418230410226488,0.3929739379922784,-0.06071667502762287,0.15358092372311394,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2285483837997622,0.13760999259713005,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025426867457042986,0.07862950976472058,0.7469074860240908,-0.18092150184656575,0.1300677669324798,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.15208043218910472,0.025268145762379204,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024611772526792555,0.05743445593429853,0.6689510184562374,-0.13819189980455343,0.08896835475096833,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.2244870769889897,0.10326879779329443,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09367082433257917,0.06550726070172443,0.15503028874644154,-0.03587376500993317,0.2232154136750915,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.17511097460218708,0.20514938784767547,0.7738863562892694,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006450553307672254,0.066986883608382,0.9234274280750486,-0.1260200802591208,0.13892118687446528,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.21706476292169838,0.06958607236442778,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01173192303885542,0.03827156708595426,0.7596592235779752,-0.06395242688716497,0.08741627296487582,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.04027835915040934,-0.01604015720324008,0.9673425418314568,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029607836962642443,0.08089998994254237,0.7149481243273923,-0.13037680997045928,0.18959248389574415,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.40361606239853565,0.10569197198439001,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057106131377077735,0.056641218581688677,0.3151450245376932,-0.05490532082567304,0.1691175835798285,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.05385400771375872,-0.05925930531201731,0.9025176929330414,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01488717033864318,0.032286471220307464,0.6454661178943623,-0.07873562943691031,0.04896128875962396,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.027640510943942796,-0.05685934650219696,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058136145814518314,0.048000605305940906,0.22793660693446643,-0.15306026011787285,0.036787968488836226,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.05169983317737407,-0.1730334060842785,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07588036181400261,0.04488018120631777,0.09317857343585023,-0.012872924183757434,0.16463364781176265,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.13920802710080915,0.1620586205489732,0.6699741992153797,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08316407324984888,0.05723484921083502,0.14851832268269102,-0.19634946610055404,0.030021319600856286,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.11886534429369115,-0.2156513824081857,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10602213302599739,0.05489803124217659,0.055531677473997496,-0.0025420602679677856,0.21458632631996255,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1463964964669677,0.17029917089394994,0.5506521745982841,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04546680894298109,0.03800238356613444,0.23361431909182417,-0.12061883209851401,0.029685214212551825,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.053567980107351136,-0.1303740723450046,0.8449482942840995,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05905576352003766,0.03843613270789347,0.12674769643289893,-0.01695402492509715,0.13506555196517248,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12476506772610424,0.10847797932184491,0.7263564310373228,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030831993381835388,0.03984575529242691,0.44040172458188354,-0.10962939615987281,0.047965409396202044,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.008097107731079023,-0.08476861651917073,0.9320838159679753,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0717332011429812,0.03831939472791736,0.06335678989023022,-0.004045730851819973,0.1475121331377824,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07803290663727652,0.07968982580049919,0.583441065137642,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00366134795012981,0.04237394224891168,0.9312710400426754,-0.08013569818881974,0.08745839408907935,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.023526976291379596,-0.08334359896911732,0.9918526261485133,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0750111385839325,0.032110891470530506,0.02095289289081778,0.011509899111979527,0.13851237805588548,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.01647361927248849,0.05617607186932967,0.3339840637897822,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017284778543961887,0.03318713009488462,0.6033337185129146,-0.08291434530563825,0.04834478821771447,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.032110271287631255,-0.1145381197388456,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07505853849636202,0.05780153252226518,0.19629384588773685,-0.03924750504374899,0.18936458203647302,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.12867672286545664,0.2100182624407972,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04280828688819837,0.054219003762704054,0.43116852261191974,-0.15002966207256374,0.06441308829616701,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.06808170968335245,-0.05899566007184357,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01968999034512939,0.04257839657514281,0.6445042032161847,-0.06451137664996938,0.10389135734022815,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.08290916645800082,0.021949542473636063,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.068332972377316,0.047117249282508544,0.14928419884300004,-0.16151019645700765,0.024844251702375628,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,-0.047077745542513254,-0.15062866242841724,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09207297485301517,0.04473383100541265,0.04147644268033025,0.0036091052722042882,0.18053684443382606,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.07741791534621045,0.08788900673127428,0.49032550277088105,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03225993739791646,0.036411641633105396,0.3771929289263768,-0.039746296905255905,0.10426617170108882,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.00582198513539236,0.02482509335617088,0.9170591775765864,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013713088641677031,0.03715883746610039,0.7126719945416333,-0.05977077083322267,0.08719694811657673,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.034256504042849266,-0.02314166870797943,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03429908103038135,0.04758201046164715,0.47224438309997785,-0.1283953985883974,0.059797236527634696,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.01963135444888077,-0.09823792547600065,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059661228708279446,0.038627961442333755,0.12478886734850868,-0.016727912717898363,0.13605037013445725,77,64,141,3,log_other_mut_burden|lin_Skin|lin_Thyroid,False,136,0.1721480330175915,0.13700268943626576,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04078214057639396,0.04102014315870706,0.3204786120633388,-0.0397585868811717,0.12132286803395961,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02930427311329652,0.1258473705631422,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0504613643958177,0.04080453552909912,0.21663814906741605,-0.029656029694362103,0.1305787584859975,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.021330624810287496,0.039289834419807226,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046753969235469636,0.029906252635720235,0.11843325853922053,-0.011965263739693102,0.10547320221063237,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.022809919830074413,0.06202986984453035,0.7204222518350135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029795794889692768,0.047163414960889764,0.5277573791052036,-0.06280689875855695,0.12239848853794248,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.038869979809127445,0.08654218172414196,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03907871923717616,0.032633016397405984,0.2315190180649848,-0.024994359923296204,0.10315179839764851,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.036985025895706264,0.0928258452699144,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03408588222803619,0.03759848910571504,0.36495085472636735,-0.03973662132012291,0.1079083857761953,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.006475411297342063,0.09301895803919631,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02611322786614636,0.04179694090672939,0.5323345527472061,-0.05595269796703337,0.1081791536993261,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.025915490281553325,0.05716252431615692,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03855989015809189,0.028479323086908127,0.1761966730515267,-0.0173576474780913,0.09447742779427509,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02122556971757607,0.12433904394599798,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026780706041330735,0.025695268869847368,0.2976679467793122,-0.02367049884569965,0.07723191092836112,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.016629787734349952,0.0491305519075781,0.8847007730863069,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05877245714428486,0.04293471710795413,0.17148694045712173,-0.0255274278093202,0.14307234209788994,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02581930498338797,0.07675892041712659,0.7848027568782422,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038455845541464403,0.027670182287801128,0.1650443430279684,-0.015872989970410367,0.09278468105333917,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02414983968437298,0.11358725587710339,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05414674521054026,0.04403052567827962,0.21921241736540584,-0.03230469779752557,0.1405981882186061,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03307243672775588,0.06969595580640729,0.8337844604918982,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04823394521554146,0.03042736919892864,0.11338018260198131,-0.011508470612216527,0.10797636104329944,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015531990406579276,0.09516581296615506,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030485548402100833,0.025200878305514072,0.22681186291360309,-0.018994948617199747,0.07996604542140141,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005215321714996858,0.05187849010919356,0.842579263271115,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05185567651728968,0.06437731713740011,0.4208137998955963,-0.07454553895267704,0.1782568919872564,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03209293575170784,0.07746948128121746,0.9279699506567693,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018542622438302892,0.047660025223463215,0.6973528239498132,-0.11212038220603954,0.07503513732943376,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.029641297541224534,0.028316740233801055,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02171544557016466,0.0226501995975194,0.3380335926772957,-0.022756938292202468,0.06618782943253179,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0017251255368987849,-0.0038063972288571186,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028906436632456053,0.02879193180160831,0.31574526314681167,-0.027624890506950342,0.08543776377186245,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01433799672151846,0.10007405060541606,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04232108534670267,0.02734517907006602,0.12216698428105793,-0.011369624757341115,0.09601179545074645,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005794794143369481,0.050952282896347026,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017821818380041668,0.02510879109898632,0.47808033241574344,-0.03147787062563047,0.0671215073857138,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0030527592794266406,0.0682963604880067,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07326673295319926,0.03854263977984341,0.057732299383226215,-0.002409556961078571,0.14894302286747707,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.018864670535838058,0.06537676043312245,0.5623055122749077,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0027371777074282583,0.0439091677473807,0.9503124854901259,-0.08347598587778116,0.08895034129263768,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0009289227208804013,0.05685499533960826,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035055875769939716,0.028331474575605687,0.21638337089784468,-0.020571369689355037,0.09068312122923447,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.06488831735778242,-0.006780394278544504,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0010596789233825242,0.04827522272424823,0.9824936269144602,-0.09584534413532003,0.093725986288555,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03270515951971402,0.04513358514175852,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0234783322802414,0.02563406442120004,0.3600407110462832,-0.026852701138868392,0.07380936569935119,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012190274125947021,0.03966652022562567,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030053308042486824,0.026819678188791305,0.26286509613321374,-0.0226056108487934,0.08271222693376705,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.05241738779607277,0.13600215043223446,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03202248421922137,0.024476772829744687,0.19121829085897601,-0.01603627271621766,0.08008124115466039,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.04334776706388136,0.023466349942992962,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037402028682787684,0.027069811216963256,0.16751934397710055,-0.015748012240226754,0.09055206960580212,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.06952218289552366,0.18515343025529302,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036540424247114574,0.027346603215415325,0.18193018706662392,-0.017153082085650175,0.09023393057987933,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.013794713465082735,0.05098351315941558,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04521860654692804,0.02554871322298358,0.07719029928949302,-0.004944844629303363,0.09538205772315944,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.05441051745129947,0.11634264999697302,0.6310366588671427,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012372214526673354,0.02432642770986101,0.6112028203503148,-0.035391348282351326,0.060135777335698026,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.023636082647110642,0.04697298940971088,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045044701282199354,0.042184434412679335,0.2859862698139824,-0.037782046099884864,0.12787144866428357,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012068551909294461,0.006788604544584829,0.8775950049080478,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028929237849644015,0.04359312776516063,0.5071579771246291,-0.05666339913293511,0.11452187483222315,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.00909515138309549,0.030326867717963876,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035732838677784706,0.026328180059037618,0.1751631782499806,-0.015961051477217388,0.0874267288327868,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.010132689044150656,0.03595696749918871,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050923538556777274,0.038855469626592726,0.19043729156826564,-0.025366975040975952,0.1272140521545305,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0006765730501524214,0.050325804713425494,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014441264361288614,0.028560841661041166,0.6132784230819956,-0.0416363303774887,0.07051885910006593,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03500152870750651,0.07925449825052158,0.9552990821084932,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07518310918394641,0.03323754173558073,0.024011282907760174,0.009923078766021165,0.14044313960187166,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0043143171456962665,0.10122811419818191,0.36513709525249094,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00488716591639027,0.02451265840824159,0.8420302013731502,-0.0530163821524269,0.04324205031964636,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.045256575639069395,0.11927487897252251,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022433431716214664,0.023182440343108148,0.33354139893217616,-0.023083976700709042,0.06795084013313837,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012776128816012856,0.035407976709038044,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019588485998473265,0.019779222395319766,0.3223505034979508,-0.019246896757276234,0.058423868754222764,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03001524860505864,0.05707846219653643,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04063721553467004,0.02480235743323159,0.10179014314389674,-0.008060808326590334,0.08933523939593041,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012754202738475657,0.04342526035287907,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014316092373165725,0.022252041142068184,0.5202059177465412,-0.02937452991607986,0.05800671466241131,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.024666117918752235,0.03524156114429614,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012471469661977834,0.023255747978709617,0.5919433132649468,-0.033189874144851576,0.05813281346880724,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015228699875200204,0.02122650137218486,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03220309741727203,0.022332730822097337,0.14976958630155943,-0.011645954487948376,0.07605214932249243,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.032169073938519255,0.07762232310773491,0.7665190045530488,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031117835316517087,0.01763989748558501,0.07816889106172276,-0.0035171041635595826,0.06575277479659375,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0017568417340465537,0.04424501240847866,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007514906492909486,0.020431709820034873,0.7131318078959883,-0.03260159836034575,0.04763141134616472,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015390854613658057,0.01399065320033396,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015461404656600541,0.023215059212217233,0.5056311502769424,-0.030120049062084403,0.06104285837528549,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015270190588100224,0.024038423366739038,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004183268914724418,0.017663618598896612,0.8128599473213266,-0.03049824562762904,0.038864783457077876,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015180792688249052,0.00666211379891847,0.9764652333287971,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017074634764213014,0.018334047984546995,0.3520236362724618,-0.018923229899598982,0.05307249942802501,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02441671090293644,0.023886222217186896,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009956092341902874,0.02288358209430479,0.6636448632237162,-0.03497452483267463,0.05488670951648038,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0165388493559495,0.04332701303458293,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012978901459980636,0.025027000425727586,0.6042104921669171,-0.06211799911183873,0.03616019619187746,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.07575415870438781,-0.11529993629922242,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01321479344928078,0.027365910037890767,0.6293267893389147,-0.04051662073575669,0.06694620763431824,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.07032533270089215,0.16943524839537275,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048713696022855656,0.048529826520834915,0.3158359125266894,-0.046571869321346444,0.14399926136705776,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.006945138531326342,0.04520973876103865,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07561688378192175,0.03294657947866186,0.022027614184774814,0.01092814127355532,0.14030562629028817,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02229669553090215,0.1731751149527997,0.34624792356186623,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0385701629939762,0.027630562035717423,0.16319097646851735,-0.015680880397268282,0.09282120638522068,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.052949889372230934,0.10057088346175604,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017606859285374508,0.0361259788818341,0.6261497721450546,-0.05332445385027869,0.0885381724210277,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04806089754886663,0.06570007408011605,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022590662941111485,0.030248609072018682,0.45542130810546066,-0.036800767503537744,0.08198209338576071,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02833374528160019,0.06469783783965544,0.934143241276782,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0035364874739538836,0.036378551069382974,0.9225853404864686,-0.06789073684470104,0.0749637117926088,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.039460127520254865,0.07741765947927778,0.9911330941645131,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031540348790325835,0.02829793932122099,0.26542200991945075,-0.024021052096628734,0.0871017496772804,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03343132390587763,0.060770133790723664,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020310061964672138,0.02670850996205587,0.4472575654314507,-0.03213058441066883,0.0727507083400131,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.017921930668000376,0.03764767866472188,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00531163752134042,0.02125187590039512,0.8027109544741273,-0.036415216971423886,0.04703849201410473,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02237216384652713,0.059909005244084955,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027867860719132238,0.027429055309305044,0.30999018364042813,-0.025987535629388537,0.08172325706765302,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.02047312153210571,-0.011911698529598475,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010865871292452284,0.030941450154064055,0.7255651798047829,-0.04988591336998999,0.07161765595489455,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0051326792215038485,-0.002224035630814064,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05878181069955189,0.03948062290368427,0.13698120877297,-0.01873615594522335,0.13629977734432713,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.009985205941950119,0.07985356736022242,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038403688534693475,0.0373394919322024,0.3040785136725159,-0.034910288734474965,0.11171766580386192,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014950890720649094,0.06665578861535752,0.891349793771208,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05138502694350686,0.03085003146385356,0.09624382067254146,-0.009187262299226992,0.11195731618624072,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,6.777025258592272e-06,0.10749934561685083,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04869042478757318,0.034898259234571974,0.16340579926566098,-0.019830330366313223,0.11721117994145959,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010672757301726071,0.05815381985465116,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0355485352028829,0.030102615123506617,0.23804880119766197,-0.02355624439386289,0.09465331479962868,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.046671504083011586,0.17186766904278714,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0687605010570597,0.031501594908298104,0.029393139328341707,0.006908903899741407,0.130612098214378,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0060661484785160475,0.10565676200148535,0.4079068880915672,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0066966715061022525,0.033442598855723565,0.8413495579244757,-0.07235931996372472,0.058965976951520206,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02371668073885613,0.06785389351851191,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009830707931277433,0.022933776988984387,0.6683085248309565,-0.035198464075654246,0.05485987993820911,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04697150974715245,0.056237232274738085,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025333262315693997,0.024188726798960534,0.29532392357791587,-0.022159932555008654,0.07282645718639665,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03736292525309662,0.0784864992250468,0.8830041858734644,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0010192091487160845,0.024651486626573033,0.9670331541190876,-0.049421006727357775,0.04738258842992561,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0061915482708906865,0.022339621013466034,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056574822498722574,0.04128305089468198,0.1710083043353835,-0.02448210940570998,0.13763175440315512,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010388077862988905,0.10038691824311118,0.7845446469755442,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0076103543201744535,0.02457780490904997,0.7569266170021037,-0.0558674820202477,0.04064677337989879,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.006162484824106823,0.01142340425855952,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029514634335240424,0.03199688129254565,0.35663410779395366,-0.03330942958146454,0.09233869825194538,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03129419821101731,0.05430206008389061,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02114925160755335,0.023336702804669266,0.3651148733689282,-0.02467104241426591,0.0669695456293726,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02985913981184539,0.037839298698585246,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0166132153667274,0.022007120105489053,0.4505681041017341,-0.02659651834103704,0.05982294907449184,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03835039116870682,0.05219524001296453,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015926507930137737,0.02459698582648916,0.9483921291415001,-0.049887439137953106,0.04670213755192556,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0046109065928881645,0.0007726848178644779,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033418982458348423,0.022245868527339875,0.8806310061357145,-0.04033660446404677,0.047020400955716454,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0011759687947885476,0.001133110832504853,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016867467019077063,0.025493093779254034,0.5084196750407851,-0.03318677853002059,0.06692171256817472,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014936041187032272,0.055375521877631506,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013781730276972968,0.019216022523695118,0.4734959308595478,-0.051511301987910735,0.023947841433964803,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.009063438076377077,-0.029681619313431037,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017866432361277693,0.0228506910384462,0.43455775438789335,-0.026999605088274255,0.06273246981082964,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026014432990532237,0.04201544236986266,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020954689566410997,0.019013959452322586,0.2708200004135401,-0.05828752188281061,0.01637814274998862,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0029050947910483566,-0.03335737469331345,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03253231803872379,0.024031931350839426,0.17627600797578677,-0.014653017851456791,0.07971765392890437,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005745115586619276,0.05935420783369283,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05141114739216326,0.0236178652538856,0.029837980728699157,0.005038806828087418,0.09778348795623909,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02188875227542453,0.09370651940998075,0.4119198104772415,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03269005739107528,0.03782569992266545,0.38776564857007434,-0.04157856172554032,0.10695867650769088,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.005539886240935238,-0.018248772972000022,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02996718985798304,0.029524137642404802,0.31046217655969616,-0.028001781973160864,0.08793616168912695,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02092376949527211,0.08782597702363018,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020380588385193875,0.02896104169519676,0.4818443271298214,-0.036482776450843385,0.07724395322123113,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.022109075322666184,0.061744428764762355,0.9400049812623549,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026760233259585736,0.024541460019324328,0.275917478820538,-0.021425533308310506,0.07494599982748198,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.00013586429422758948,0.034702125551868995,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04094481863043917,0.03226786612041873,0.20490763040675888,-0.022411308645538308,0.10430094590641664,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.022771179987463263,0.05803452488513924,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026296111624761385,0.02275816532961316,0.24830683952061028,-0.018388256836725167,0.07098048008624794,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.028189946353845332,0.05326018788741632,0.8577283255503066,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043498836635244405,0.02807376306319153,0.12173727318770472,-0.011622406867798765,0.09862008013828757,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014356406457573932,0.09235303970961375,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03942397316501326,0.025672854125818347,0.12509254659175448,-0.010983221641825844,0.08983116797185237,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.027238405784474045,0.09083074009595853,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04079627122294132,0.029793100539916753,0.17134952954637694,-0.01770079402174566,0.09929333646762831,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014865688043753631,0.07609698789892487,0.7848027568782422,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008670764287181616,0.02245108472968658,0.6994637052669835,-0.05275219738565634,0.03541066881129311,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.004177636714679587,0.1018559587341281,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027310505123277443,0.024322836378746413,0.2619025856494853,-0.020446006310538924,0.0750670165570938,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.002605258984180547,0.09982764457746206,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04360683374066015,0.03159267851108421,0.16795114408065895,-0.01842360091119019,0.10563726839251049,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02202799818233869,0.08293695629945486,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026644012020397522,0.02415328535279063,0.27036286103039175,-0.020779595578373184,0.07406761961916823,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.021201641382363013,0.06867357706888459,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008129561410839271,0.022563903819759472,0.7187412511299901,-0.03617338558022269,0.05243250840190124,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.008255403457942047,0.06114717234751716,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03028362135699115,0.02310150739308245,0.19033424817017155,-0.01507487979709983,0.07564212251108213,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04093239513508484,0.07613957726499844,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002182028158268705,0.01892063924302084,0.9082211920402845,-0.039331631529938044,0.03496757521340063,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013715160137181293,0.017251265707452522,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02161732694906948,0.02533917044125319,0.39389240976451967,-0.028134698845033165,0.07136935274317212,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.007076872300142219,0.03678676018307436,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0008824297382707973,0.0376689800983275,0.9813173881280871,-0.07484333835737875,0.07307847888083716,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.03315351652872148,0.008863209569760088,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04162415260597045,0.026816258603304867,0.1210779917660887,-0.011028052122913613,0.09427635733485451,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010008009499574304,0.07785022796656588,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025386039858790337,0.03425266871996295,0.4588629940293609,-0.041867134889899994,0.09263921460748067,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.029028951851795597,0.07357361824654753,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024941811613322984,0.025968540993450816,0.3371623464107242,-0.026045947608579922,0.07592957083522589,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013292296258546268,0.046511554417866426,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01218266503548332,0.036406896207154,0.7380105638339685,-0.05930021335554114,0.08366554342650778,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.02516495852715249,0.04710023294539255,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021296532432212995,0.01803274932725061,0.23801699027133572,-0.05670281424984256,0.014109749385416571,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0026503619082184275,-0.04927772967476288,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00042834134421489584,0.021005576816590175,0.9837367874676265,-0.04167160153783129,0.04081491884940149,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0008592348047044475,-0.010741673820419741,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016625003949157276,0.020795461850145684,0.42430545902673256,-0.024205707410056298,0.05745571530837085,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.020367902333799325,0.03820888377884125,0.9293975534641841,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012016142785791472,0.023955544863172955,0.6161093421220581,-0.03501921256285899,0.05905149813444194,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014731615469530947,0.03823647084391798,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06931315281685511,0.03719705949867203,0.0628344005370996,-0.0037211664373302117,0.14234747207104043,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026244865779682137,0.12347804171835625,0.5817074626033015,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013567353015168952,0.032685272067893734,0.6782058520688761,-0.0506083271942218,0.07774303322455971,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02953658623836571,0.08194426633216653,0.9621651627753025,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009493150415640804,0.021398393470375306,0.6574444942533071,-0.05150768385740006,0.03252138302611845,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.004759092979599836,0.021220700867060703,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040727875690638016,0.02595875944983111,0.11712381049690784,-0.010240678024454712,0.09169642940573075,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026299561563344485,0.08985226838502103,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01688746095828236,0.025414686879493806,0.506609684759556,-0.033012837084587715,0.06678775900115244,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015003973958362836,0.06124909074405179,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041020378207891985,0.02891852344248268,0.1565064830989762,-0.01575950444743792,0.09780026086322188,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03139263922390556,0.10763120641889883,0.7769533851405084,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00953760249157201,0.026889207459848283,0.7229238251435455,-0.04325783318486074,0.06233303816800476,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0022896447940366498,0.009035481457260049,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04416712855998399,0.02849171907908903,0.12156292262967781,-0.011774747904660758,0.10010900502462874,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.028707490321306685,0.08964995460344093,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053060600494465156,0.03227227408788898,0.10060449317533224,-0.010304181575945613,0.11642538256487592,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01065305665575915,0.09890695648973509,0.6818291067720451,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044085000841414014,0.0382030639875553,0.2489181239369165,-0.030924551240378746,0.11909455292320678,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.04517089704270346,0.10382829820098342,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0594875798881604,0.03428545286552206,0.08317991003577128,-0.007829964673238508,0.1268051244495593,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02694019221494952,0.13330650704838182,0.6475069956953327,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018106142256178542,0.04291774051976497,0.6732452625414457,-0.06616041012817603,0.10237269464053311,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007362035525114893,0.02522833314801792,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059306762756217934,0.041426156513726026,0.15270831391580392,-0.022031148924820443,0.1406446744372563,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0117770200746851,0.10748772453828166,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028356307169393927,0.030412858961167834,0.35147022762715385,-0.03135761862847031,0.08807023296725816,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.024347681014760047,0.09269468710812111,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009669296379103002,0.022924669218850283,0.6733142052238175,-0.035341993037090784,0.054680585795296784,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013785341206827272,0.05543532406361974,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02889745432756458,0.02463746471251374,0.24124200714442948,-0.019476812017109612,0.07727172067223877,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.060419468596204166,0.020029066121317805,0.8487082760058587,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03280260282049918,0.02336865471272696,0.16086241664264578,-0.07868563260383607,0.013080426962837712,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01954102682396147,-0.06767378070236431,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013688698931180994,0.025037810423154533,0.5847489284541812,-0.03547162353827981,0.0628490214006418,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.01270542128373159,0.02196557452694504,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02799733398204259,0.03736829509675697,0.4539783832258013,-0.045373196669139415,0.10136786463322459,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0359228310722054,0.09888323433106459,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012024471996932773,0.02147264325003335,0.5756696636560261,-0.03013584668121841,0.05418479067508396,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.03886119575800559,-0.051368998362982414,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-6.244048124243726e-05,0.01994693411622201,0.9975032763572078,-0.039227115700754586,0.03910223473826971,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0042122813004208505,0.01015149267271335,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021482206380939787,0.02447208944311072,0.380347498355337,-0.026567354990139427,0.069531767752019,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.025471383174590058,0.06890457652143366,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020560409355964537,0.021993825160521965,0.3502081343832081,-0.02262322048046491,0.06374403919239399,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.00905070316594574,0.004603027632528911,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0256932894461187,0.023569611001618817,0.27605248185024284,-0.02058430662705054,0.07197088551928793,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.026714603922860226,0.0887483267655218,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008894201477752177,0.019288180047381455,0.6448579819885107,-0.028977047443495392,0.04676545039899974,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0067046474334283,0.024711743941136344,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006702756041002429,0.02178002421533452,0.7583680132804894,-0.036061087750559044,0.0494665998325639,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03294463791826067,0.03802146756237223,0.9669418369722411,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046378414714243,0.03914562241252761,0.2365219460942304,-0.03048179744264542,0.12323862687113141,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03708161558178394,0.10719750968443471,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039316117663553696,0.029077661798390334,0.17678854398430469,-0.01777622413902038,0.09640845946612778,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0004702514881725755,0.0333805754907128,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019762901608012785,0.022933001088062715,0.38911824367770276,-0.025264746961411018,0.0647905501774366,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007928648089984653,0.03884756278938189,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03630889878353341,0.04160642841376971,0.38314681869134626,-0.045382966561525614,0.11800076412859244,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0028399030541244475,0.05035496935255043,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04988370562275687,0.029218209964990572,0.08822424483060423,-0.007484594543419543,0.10725200578893328,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.020106219173651137,0.0942970126312463,0.659371665428829,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008953134165372592,0.03235858653152844,0.7821057318346141,-0.05458111749885375,0.07248738582959893,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.00019216300690882437,0.052494716634130335,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04860677265347097,0.03253542871175297,0.13564674391786297,-0.015274698614191638,0.11248824392113357,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.028772272443916076,0.08702625853899638,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011196670000418822,0.04061819568460859,0.7828952807008402,-0.06855485636054484,0.09094819636138249,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.047718688247740865,-0.014063528603693287,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018725469395062144,0.039604626618323084,0.6364996856822743,-0.059035971519069225,0.09648691030919351,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0182033954303416,-0.0015039531179984534,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06236869628773869,0.037424462497981044,0.09606793932765885,-0.011112115874077864,0.13584950844955523,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015286774912264838,0.1084339796208153,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026277227202305655,0.03372902729519479,0.4362091275101756,-0.0399478072711406,0.09250226167575192,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.01634221127625353,0.045776975014745716,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04354121360485846,0.030818237591316976,0.15815853635743507,-0.01696865017015136,0.10405107737986827,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.05588427974087571,-0.006796624941690701,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056290652170099216,0.06974974109061789,0.41992585766598434,-0.08065901340469767,0.19324031774489608,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.2910797385366717,0.422026222179962,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007457256328845587,0.026060591708254182,0.7748494779067114,-0.043711239257252045,0.058625751914943215,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02881274545732785,0.05872310826539266,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0008404990938616964,0.025147349558497522,0.973347057872296,-0.04853489726287111,0.0502158954505945,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03380452601398873,0.04799467612584702,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02565808345757814,0.0327170334451774,0.4331698134200249,-0.03857995841694829,0.08989612533210457,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.024031676571963,0.016404249149701896,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0013171230344382898,0.02201984279858887,0.952320253794271,-0.044551837029412206,0.04191759096053563,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.02470134836369088,0.045070644085121916,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027664390344736615,0.030831178323452595,0.3698823964705106,-0.0328708818247784,0.08819966251425163,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.012220067420359427,0.0063721920890231895,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029890672810559724,0.03337442948084106,0.37077342069877073,-0.03563812894101584,0.09541947456213529,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.018516981967181136,0.014920164664821562,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017320196831230344,0.024827924076924652,0.48565881335054406,-0.03142802568666857,0.06606841934912926,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007607913142872532,0.0373785697333303,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,1.4776715323900252e-05,0.020373839486485704,0.9994215230163429,-0.03998810301614108,0.040017656446788875,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.007644989183650904,-0.02384420475783918,0.999766777543677,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03677708118045855,0.026024288642264696,0.15805749544206504,-0.014320135391998869,0.08787429775291597,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.043194013930129185,0.08940659804857551,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002197594564455419,0.03063074980435175,0.9428260695205404,-0.05794414756131576,0.06233933669022659,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.020148537044743547,0.004840482237631882,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0656464381708383,0.046594117527093755,0.15931991635687998,-0.025838472214679845,0.15713134855635646,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.022129454818533564,0.1046995182697462,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03698419819751296,0.033684240532706855,0.27260563812919425,-0.029152900004787416,0.10312129639981334,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0019690326818179015,0.06017584079256711,0.8700354117066056,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022700373492767077,0.03923538654542344,0.5630708399566375,-0.05433608545426677,0.09973683243980092,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.010042176817635728,0.02818333305996685,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08165380689610592,0.043596626193133245,0.06150378789301705,-0.00394569905162484,0.16725331284383668,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.005658292286301493,0.12077745088924037,0.5784562420554139,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02916671379961894,0.023585290258011544,0.21664266795645912,-0.01714166760530739,0.07547509520454528,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.03327190104447973,0.07708782107277151,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004988328577872065,0.0448283379514689,0.9114299933600449,-0.09300623079132464,0.0830295736355805,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.06972128780789377,0.007411621652456965,0.9891894021454795,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030975147096449655,0.03454245623808505,0.37018065852949267,-0.036847009028716494,0.09879730322161581,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.015335189784962643,0.025242028075499655,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005661490398603646,0.018663922669372987,0.7617241155825398,-0.042307045319929557,0.030984064522722263,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.013268825481912449,-0.0035747071412141128,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0249990463519817,0.022558927645609073,0.2681800252397989,-0.01929413020301723,0.06929222290698063,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.06262381446625463,0.09182593883775982,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04787245373946868,0.02129151498442338,0.024866916248867648,-0.08967713732831965,-0.006067770150617713,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.008603280106414993,-0.08896254597427461,0.37244071921417243,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0026073201128860584,0.029522649476345145,0.9296514696862915,-0.05535872978849864,0.06057337001427075,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.10028069717715273,0.11912828716232447,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0835548238232221,0.025781721688542324,0.0012495634636910614,-0.13417577392253782,-0.032933873723906396,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.024722769593689187,-0.140623179778514,0.043314562335282296,0.4139440736449076 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03212709063572249,0.02155840021403592,0.13662400212276243,-0.010201606983443016,0.074455788254888,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.049598364904438634,0.0889498243723257,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04419318246672825,0.019856122846832,0.02636193865833925,-0.08317955490290493,-0.0052068100305515605,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0018714763277953021,-0.0665154352727082,0.38256136941480245,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03367996539649643,0.023294433178356715,0.1486814745015508,-0.012057334608471137,0.079417265401464,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.024738720485988273,0.053338586166753466,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031269884016252004,0.01796278123243474,0.08216628103001643,-0.06653878744313615,0.003999019410632139,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.014989726723210936,-0.025086814226704595,0.6432307088917855,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020905365514748624,0.021346742147429786,0.3277669314923656,-0.021007753480257418,0.06281848450975466,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.004759543974808072,0.01940796427414917,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04042090739450509,0.019149639373655537,0.035153043517981535,-0.07802013955069223,-0.0028216752383179375,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.018174969495021228,-0.01744213249550145,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012452177375888588,0.01874031437346848,0.5066206110373229,-0.024343368329130338,0.04924772308090751,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.025635739709745767,0.04636082846449609,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04112932348457876,0.027959874369239166,0.14174830103804506,-0.09602695298840633,0.013768306019248798,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0095827137185393,-0.10937783004461656,0.7604630965928677,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029138106205838638,0.028850943726905654,0.31287531123140744,-0.027509087506088745,0.08578529991776603,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.06984504727915705,0.10131672192326724,0.9005091445086701,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016453101437502834,0.018594881775338738,0.3765657350437803,-0.052963098474295645,0.02005689559928998,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.008689126122460079,-0.023404931083047455,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04707182461193998,0.026455050581228656,0.07563302144229557,-0.0048711686266533355,0.0990148178505333,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.046845854262734625,0.09079779807991467,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044533163314380064,0.02051420207220635,0.030286574881541527,-0.08481163703190275,-0.004254689596857382,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.019490564458846327,-0.037215215586594456,0.4159426148956344,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00043589415545828496,0.02143165339480721,0.9837790427571691,-0.0425157315747918,0.04164394326387523,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.017594325842828266,0.014524165241930433,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0028314793702494522,0.019488461325566597,0.8845247413990621,-0.035433010495544606,0.041095969236043514,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.0008537904642503175,-0.01953809238348165,0.9880940960671373,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07788269614045235,0.031333013616728606,0.0131698684081563,0.01636209879964398,0.1394032934812607,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,0.0498129925728819,0.19137167610008107,0.2450248350502534,1.0 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056393885525007556,0.02756300576410177,0.041138909635188736,-0.11051228600373966,-0.0022754850462754495,611,86,697,12,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Skin|lin_Uterus,False,683,-0.02121855914529431,-0.06820058388713113,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09888846902392129,0.057260725298719006,0.08503516635905328,-0.013722260133146716,0.21149919818098928,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.024954985337060788,0.06783018598535695,0.6528134918357494,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07107123995046925,0.059213527138371365,0.2308367743784209,-0.04537993024040164,0.18752241014134013,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.045109448077540304,0.08027233276012928,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06876076292036372,0.03106857765876227,0.02751624162943493,0.007660328621385652,0.12986119721934178,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.055482119239406526,-0.02108312929877293,0.39228691037577734,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10911089381340536,0.060472734058528405,0.07202713119437819,-0.009816671999399479,0.2280384596262102,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16896255774764227,0.21689689400491954,0.620887427285682,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06227626962893766,0.043412698397833405,0.15230006331528873,-0.023100497705954348,0.14765303696382967,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06588241278633959,0.03549412196939106,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09384086439050608,0.03592090687887656,0.00936988410986694,0.023197688033396224,0.16448404074761594,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.09740736494850649,-0.06352472379715551,0.1983417068376634,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07187957583417597,0.052266281051307754,0.16991411253040892,-0.03090892341746876,0.1746680750858207,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08943495263279526,0.07802917886174704,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09165446752810028,0.033614979198692274,0.006714877012990072,0.025546200501851232,0.1577627345543493,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.0703273840520751,-0.0763689696026791,0.15751637494854673,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06363500091262958,0.033282208383860826,0.05667863685581687,-0.0018188286452697766,0.12908883047052894,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04962084153961675,0.06205606387781458,0.5568255190117257,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07585198568313825,0.05791468547336515,0.1911329828599607,-0.03804484195980125,0.18974881332607774,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16577706384286106,0.17764518074737573,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05319733180714468,0.03646550115175349,0.14548840165409807,-0.018516860640723755,0.12491152425501312,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01708600601186693,0.013543986350465173,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062394403200583606,0.06311463193914474,0.3235340302367702,-0.061728801422988686,0.18651760782415588,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.17577798842483763,0.17231788950282967,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04221592741549511,0.041600685627191845,0.31089356343900976,-0.03959727906194423,0.12402913389293445,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04790967576544069,0.036970120743207824,0.8977348514291958,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037067527929382074,0.030579711095069163,0.22625243196110179,-0.02307148613066614,0.0972065419894303,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03586001957045212,0.0056433900569967475,0.8420027214754927,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18909148166757422,0.08742841610439848,0.031218813259339194,0.017152030408403518,0.36103093292674493,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.06281877049204192,0.1264184347603936,0.42195400245230363,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19968798782441075,0.07165796965736838,0.005609638338012976,0.05876318865474617,0.3406127869940753,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.29288837965961895,-0.14294937107844463,0.1422661633455176,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009669783383627222,0.029354584596864033,0.7420366824927298,-0.06739942544301006,0.048059858675755615,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07015297137937354,0.028478161448401613,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06674909958040873,0.03858810371438448,0.08453311005085287,-0.009139469301596218,0.14263766846241366,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.030294505944230575,0.0386869927384873,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012088272354549323,0.03476807319221198,0.728283069251418,-0.056287705300922135,0.08046425001002078,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.061645381560115356,0.02861166044143261,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08340123894842984,0.037945647716067274,0.02859683502650092,0.008776144080147374,0.1580263338167123,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.006391850590136473,0.057062360948704434,0.4029256832771177,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029081341898175017,0.05321805672443534,0.5850936807292262,-0.07557894909179849,0.13374163288814853,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.040652432060744655,0.022211221482222477,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13127804633405474,0.05075646710706423,0.010092741517000896,0.03145879429794564,0.23109729837016385,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02189029893804766,0.09728108613606008,0.20399134085447534,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057799959044824774,0.03264112324983755,0.07745202634426893,-0.006393092483849484,0.12199301057349904,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.08069381525604494,-0.045531937514028197,0.6318748048518055,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1135994880252586,0.05857108156012439,0.053226129775359295,-0.0015882286443250765,0.22878720469484226,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.1253160828526922,0.16110951434457763,0.5411630668077272,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0589045556892429,0.034544276222708115,0.08902888720589604,-0.00903129586255979,0.1268404072410456,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.022302138530421765,0.024911454616943336,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04666009144924467,0.033391148076631676,0.16316743024473954,-0.019007982307851834,0.11232816520634117,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.010938324057867987,-0.04753533989291494,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05482432384831677,0.030561346843328164,0.07367354560886256,-0.005278574501212767,0.11492722219784632,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04845394857029295,-0.0314518782485145,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032605737298093185,0.03682521008444582,0.37652672017657096,-0.03981586996129703,0.1050273445574834,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04712594763993252,-0.0971356864114039,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05214173495738353,0.031732862372093114,0.10123307346352496,-0.010265102387414037,0.1145485723021811,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.007395332090026437,-0.015025118318452664,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06435561757824876,0.035141018591827444,0.06788103081352528,-0.0047538061376310725,0.1334650412941286,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06701676724884201,0.07739753118598282,0.6004485385751404,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018140499217192865,0.03442377422476413,0.598537621243047,-0.04955836934526478,0.08583936777965051,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0710607034998417,0.018510400585521336,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049972309342586826,0.0570643805657267,0.3817721370826225,-0.06225228213576567,0.16219690082093932,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0822837862011885,0.07235981549175634,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11372883668353617,0.057160617108479035,0.04739359033068091,0.0013149834172066638,0.2261426899498657,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10294359123816246,0.15415406811368348,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023822145444877697,0.03497227349958814,0.4962040443327719,-0.04495541890702076,0.09259970979677615,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.018550119627830458,-0.0015343455385719233,0.9429080290807693,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031188630528147732,0.05120627446141565,0.5428599313488911,-0.06951522668698201,0.13189248774327747,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10623940266027479,0.08842682833651554,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06710180220404954,0.03501361671603723,0.05610618303882089,-0.0017570690074065337,0.1359606734155056,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.013409040880047242,0.03909053845034605,0.5518846108576955,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016847508538507177,0.041522571850576416,0.685174234455372,-0.09850709402536377,0.06481207694834941,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.023867929542175544,-0.05981738305137192,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03326687285191832,0.03364345646183827,0.3234274537396471,-0.032897398448648585,0.09943114415248522,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.046760758566720705,-0.0761036359063639,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03057097455483626,0.028442626518292494,0.28317695427335743,-0.02536518229015449,0.08650713139982702,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.029457293103283405,-0.05878841579902814,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047826954746576056,0.029789779216266753,0.10927193799475328,-0.010758554631296185,0.1064124641244483,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03636989543120775,0.011074685433992709,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02058824101464362,0.03139362473780459,0.5123690429894432,-0.04115144101286697,0.08232792304215421,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.016753588541850835,-0.047424498332552904,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06257484363033412,0.035179877016420766,0.07613798855306782,-0.006611000275903417,0.13176068753657166,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07753969521909981,0.08834836749847488,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06062575274247053,0.02919116671730289,0.03852993492226078,0.0032174933843838877,0.11803401210055717,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.044127711386127026,0.050595077594166975,0.472721210839113,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013762704162662953,0.031255111913232096,0.6599613428910117,-0.04770457422183855,0.07522998254716445,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.044951221792338784,-0.03335372049456586,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05007129242180411,0.03309004284120456,0.13111791719622984,-0.015004618383503573,0.11514720322711179,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01882677314220573,0.04329332703217677,0.7360778123788349,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015077470866040157,0.028968183420004043,0.6030490362662189,-0.04189226258152623,0.07204720431360655,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0471298352649548,0.02434385035173197,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016223808359384286,0.032676449971368364,0.6198483147320768,-0.04803871780220042,0.08048633452096898,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08157292834387113,0.046566749314712746,0.9578267320115292,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05222586158369208,0.027921031470383124,0.06223456637720136,-0.0026845101640375277,0.10713623333142169,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.047493278522951723,0.08341893880163086,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03596061340925835,0.026541774074788835,0.17631619420767383,-0.016237267705443488,0.08815849452396018,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.030181743436921427,0.02884887205896953,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055307952578046014,0.030761793005789243,0.07303082261586726,-0.005189149449374819,0.11580505460546685,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.032947453618710265,0.02712391444258759,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11414536599766043,0.036639358276820994,0.001985809173598861,0.04208926070253295,0.1862014712927879,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.03018990791705752,0.09784818067520598,0.06374504020225781,0.6091919251481692 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016575001049571016,0.0348718481618866,0.6348554237739514,-0.05200506369949463,0.08515506579863667,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.09216685949728606,-0.21381409584143987,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11326647831486139,0.06105020871270526,0.06437744250954223,-0.006796767172577892,0.23332972380230066,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.018954937286683383,0.0681670620893324,0.5880149074273526,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06741949452264834,0.031189111399077086,0.031310394257014214,0.006082014808788255,0.12875697423650842,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.031019446313929066,-0.0042944186565951475,0.4219726818542934,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06676839110806332,0.03387485249856316,0.049492362388980485,0.00014904914110672185,0.13338773307501992,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06432505783934171,0.06634183220037211,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020019258142713665,0.05377737744386363,0.7099188912118068,-0.08574101042733576,0.12577952671276307,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.15164923073150355,0.05048794852220548,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04737972496130696,0.03905376018771096,0.22585837021143804,-0.02942461847165667,0.1241840683942706,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0026103081680170707,-0.026637324808255616,0.8409304609467143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10655532565435803,0.05176803456184893,0.04028450571430732,0.004746693496348639,0.20836395781236744,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16414083989436537,0.2238858038023843,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08076446915764965,0.04263365135667135,0.05898214551455036,-0.003080199956424362,0.16460913827172366,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08698702980565107,0.10924323565813054,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01746304211229483,0.037576824559871165,0.6424088050676313,-0.05643671362811976,0.09136279785270943,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09746932578163421,0.05977177356835998,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011497199501186004,0.02447782220631902,0.6388571096553184,-0.036641649464674395,0.0596360484670464,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04034976349228313,-0.10560372706107335,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0760676848868638,0.03565269821319842,0.03355888888026976,0.005951976060957834,0.14618339371276978,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07280724670334898,0.1628053099704124,0.43742275850834383,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043556155435663664,0.04132689242560481,0.29262216418662,-0.03771860078799145,0.12483091165931878,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04221274110889134,-0.0021265680696050384,0.8801950508955626,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1199692813945269,0.04396519284150078,0.006672414997233688,0.033505961246480004,0.20643260154257378,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09175752864837554,0.17725868563407676,0.15716804227905345,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10020976070272072,0.03963057321917566,0.011882169891209403,0.022271038762993883,0.17814848264244756,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.010997960835420588,0.049466020337859115,0.22774355289058826,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06139307395276088,0.032306166006659046,0.058192364039849565,-0.002141240209350262,0.12492738811487202,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.029110951345449422,-0.04400085861004039,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06146940485799915,0.03918859481911728,0.11763792270470917,-0.01560010856851729,0.1385389182845156,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04517189358311209,0.06077596964357664,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06652299694372284,0.03800802216494802,0.08093671142890489,-0.008224765462083616,0.1412707593495293,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.09655205114238631,-0.15254154459566235,0.6399159515165806,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041781838658493914,0.032363592839912574,0.1975343232413812,-0.021865412905861525,0.10542909022284935,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04228251623900068,-0.090192494464619,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07867523869056811,0.0353158985570245,0.026519398271793886,0.009221890578113373,0.14812858680302285,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.05675178973034936,-0.06615951793225601,0.3841441304406932,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02232173747509347,0.03332781168969766,0.5034417953292385,-0.04322177696708682,0.08786525191727376,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09646959901027066,0.06844519348309534,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027255188661604302,0.03657613590092541,0.4566633845501029,-0.0446765815362728,0.0991869588594814,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05887616164900936,0.007563588504836087,0.9353936944091839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026905357809120473,0.03217535980214495,0.40359611384434446,-0.03637170878946862,0.09018242440770956,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.021476138430242885,-0.004778288021673276,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09921853516316931,0.05964970372752237,0.09711928450828303,-0.0180904335185397,0.21652750384487832,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10669744197461639,0.1502479244262133,0.6756642247386071,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05864236289506728,0.029394034550313253,0.04679795520516533,0.0008351373262204323,0.11644958846391412,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.026482115952441744,-0.03836295497270291,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04813645546148792,0.04980010206817414,0.3344016174123544,-0.04980197924637559,0.14607489016935143,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.1439306888142846,0.11843124987048494,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03607515253565319,0.03245737968356332,0.2671173842998266,-0.027756543161984754,0.09990684823329113,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07339928121992886,0.07076216342616785,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025788002689321386,0.035667521865375584,0.47014667008537747,-0.04435685879351886,0.09593286417216162,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10017170257266023,0.06037057782359266,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04668436544881413,0.03407460595017231,0.17152814864713758,-0.02032781788925675,0.11369654878688501,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.056093730462820596,0.05189668310005862,0.7848027568782422,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026531513392627656,0.02992375167438576,0.37587110235690135,-0.032317470401906995,0.0853804971871623,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.038239667800118275,0.023768689066024955,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02072482221271944,0.037579979800264236,0.5816457608438154,-0.05318113872190944,0.09463078314734832,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06994834912871407,0.03459002400023704,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012953208242724603,0.030136035648333784,0.667582585076291,-0.046313259839162964,0.07221967632461217,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06307868168701641,0.02719027934124626,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04105634026940579,0.03119867793733032,0.18903046405606427,-0.020299953297100853,0.10241263383591244,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03746107336136502,0.01934815335239936,0.8093440257157704,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01955452215633733,0.024627185356907964,0.42771020751158295,-0.028878069042253644,0.0679871133549283,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05659682580386335,0.030428586693193566,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05854952975487018,0.03083761378867723,0.05841793187014152,-0.0020966837901175983,0.11919574329985796,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.025126206032857833,0.03458171921558047,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04895934424980122,0.02935025109712613,0.0961714004308327,-0.008761775413772946,0.10668046391337539,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.016445765536577058,0.018217628582197127,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035886033116471934,0.06892458851339946,0.6029288618942114,-0.09966321340203879,0.17143527963498265,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.16437095873284457,0.18284796319417163,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08225649267859085,0.03901839982897971,0.03571482532582183,0.005521690030505663,0.15899129532667605,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.062237055820041284,0.11035539381705042,0.45290755634531366,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05080267973763036,0.04405259937479718,0.249588449750306,-0.03583253682626264,0.13743789630152337,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07556958741107107,0.06541101993175205,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0284002648562667,0.029008538738870403,0.3282275312909072,-0.028648832620644393,0.08544936233317779,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.03312163321816831,-0.05553756947108151,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06139737793578596,0.047716016883780236,0.1990239888169785,-0.03244242981589245,0.15523718568746436,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.11227955171337194,0.1239730652251888,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032294978390058904,0.03247480994752216,0.32067134284055476,-0.03157099620858082,0.09616095298869863,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.057117362483536584,0.02613202637717319,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08421310801774945,0.03644542112854389,0.0214208161194825,0.012538405570109407,0.1558878104653895,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.021846884691224637,0.04713598493992449,0.338048585201694,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021682649497438578,0.032255425470637304,0.5018802915584534,-0.041751876743205976,0.08511717573808313,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.026977450922169847,-0.008976177535430832,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0828156296869042,0.04391038606102098,0.06010454155881105,-0.0035399057364402936,0.1691711651102487,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0872503529529537,0.1055441642552205,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03615414193786688,0.026180110861804096,0.16814975092688597,-0.015332481016708047,0.08764076489244181,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.14340102888452824,-0.18695529418961643,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05684597821337304,0.027437664042456882,0.038999634816201244,0.0028862119325771263,0.11080574449416895,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.12683863757834402,-0.1341918720528269,0.4740874443660114,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05291300302270524,0.04532855165718491,0.24385954501499493,-0.036231541115013005,0.1420575471604235,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08933281506771193,0.07825222671615846,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08536917820360951,0.034698857957627394,0.014355551666149012,0.017129321388289584,0.15360903501892942,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05105984910259488,0.08526131895177404,0.26196406695607094,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034817529147719364,0.029017219000609017,0.23097695719556793,-0.022248639202788953,0.09188369749822768,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.06873841181013703,-0.10392488425986411,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059752568709865644,0.03685985200122706,0.10588450163755248,-0.012737166424045598,0.1322423038437769,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03562815597156817,0.02343545031555666,0.688943585244993,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01890491400639434,0.0283421760879413,0.5051876353442484,-0.0368336938877758,0.07464352190056447,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.035080239089991826,0.04131416360302215,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005366908970725854,0.029825169618465028,0.8572973466203075,-0.05328820027644457,0.06402201821789627,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.026608083017207514,-0.09142338936962432,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07288897385998454,0.03647440329178448,0.046435720743573376,0.0011572741857455299,0.14462067353422353,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.11244991945354707,-0.06998142873270326,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037392558767609496,0.03410822829784426,0.2736902232449531,-0.02968574732855707,0.10447086486377606,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.002110054001533696,-0.029412619830176307,0.870270919138952,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09443465870592654,0.03435017468582688,0.006278351134509016,0.026880533293369813,0.16198878411848328,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.14006184703185282,-0.08138170843323735,0.15242453109708493,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019241184054508607,0.030728881738441557,0.531610404576554,-0.04119119364757105,0.07967356175658827,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.022886331153495816,-0.07571922801291306,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10505697353606526,0.03748183102229528,0.005341383683900579,0.03134403505086049,0.17876991202127002,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.11317525884170888,-0.03049461677152581,0.13766202494416493,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04829207587096714,0.027797678856154147,0.08320195711882582,-0.006375706776479681,0.10295985851841397,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05338883352792425,0.061800777467618966,0.6475069956953327,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003993128330504681,0.027870431296125906,0.8861540517578959,-0.0588039881965937,0.050817731535584346,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.009520458265826946,-0.049716836415387725,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03323793517846607,0.03149594485558219,0.29199794753992103,-0.02870297278550031,0.09517884314243245,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02821213107039338,0.005939703536240654,0.8799526010712531,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026542071627081748,0.03035236995543532,0.38245320693524976,-0.033149846253726516,0.08623398950789002,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03957414422347849,-0.013084016215030603,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0643493686216596,0.049758486288674714,0.1967663219312548,-0.03350722319564635,0.16220596043896557,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01575393449433669,5.515706065860604e-05,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06633338187012158,0.04115757037832257,0.10791237611771891,-0.014608380331761206,0.14727514407200437,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07262570055288736,0.06520783606654046,0.6967044957001925,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029828251051392963,0.02130457821411127,0.16235587479801863,-0.012069997260325978,0.0717264993631119,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.0566930481820351,-0.09369073586548203,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052881497109557446,0.03456428761505486,0.1269156424601621,-0.015093709470877167,0.12085670368999206,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04254207482142169,0.03508298760833427,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055739032928648596,0.03067355521218973,0.07002951741163999,-0.004584537900475062,0.11606260375777225,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.013620753805594374,-0.028034748324400064,0.6115448946244205,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06064297830866555,0.03717281814336002,0.10369203586017703,-0.012462245806274294,0.1337482024236054,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05542598474785137,0.0496263588560022,0.6847815146905868,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0600156473861292,0.03127984682525369,0.05582351154930882,-0.0015002754481912017,0.12153157022044961,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.05109232473616118,0.05278287401691105,0.5511530282069819,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051820072064148875,0.04033663734795431,0.19973360484259242,-0.02750721762351728,0.13114736175181502,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06178230389849286,0.05039645143490886,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06835523436709284,0.03468219372322845,0.04950710879482383,0.00014814995513874607,0.13656231877904695,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.0593090663537233,-0.0457661315265997,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053598682559424515,0.048110792858526215,0.2659996036316219,-0.04101750394292318,0.14821486906177223,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.12481614278135586,0.09159180063610799,0.86964779803452,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08048236815123175,0.03957195419580197,0.042708398729143726,0.0026589282120410423,0.15830580809042244,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.008655796032688116,0.04141729803908803,0.49583625418844224,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09186142964933047,0.05539689844133103,0.09814708827231604,-0.017083839450463642,0.2008066987491246,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.11510208571719435,0.1404995381071609,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07068861821993619,0.049286935246309324,0.15238303135891282,-0.026240606603002856,0.16761784304287525,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.023033630972965152,-0.0026316340478836076,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06516440987137671,0.040020544929255324,0.10434894577447658,-0.013541242602212608,0.14387006234496602,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07367234283079833,0.07724482555841505,0.686265063428165,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01186792978720667,0.02811494906687059,0.6731902914836864,-0.043423806356850767,0.0671596659312641,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.004188748433528197,-0.06911004662071653,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0791124037367826,0.029870111708017504,0.00844274058264252,0.020368909973908896,0.13785589749965632,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.1378520479771287,-0.09193716433478452,0.1877705709914981,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0390792406063368,0.03783835991439969,0.30239933058388163,-0.113493339936012,0.0353348587233384,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10559042093349404,-0.07060241208442347,0.8904632102898862,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04833681875196914,0.03738863156764726,0.1969089204193321,-0.025192830777494984,0.12186646828143327,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.020294271548911186,0.019403720392217133,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07050701642631368,0.05479737684288967,0.1990374786486636,-0.03725921479029451,0.17827324764292188,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.12061309449075623,0.10731141644100259,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08130056033853258,0.05535777267234352,0.14281141115965038,-0.027567762803075893,0.19016888348014105,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.004489407232021173,0.1293158709485105,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013948305889322448,0.029560852881340617,0.6373216983856347,-0.044186989814783,0.0720836015934279,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0026009863981335574,-0.03269394834197577,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07228817559509619,0.034455344660376024,0.036605390746412676,0.004527219628828766,0.14004913156136362,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.045975426973104444,0.08153765846185258,0.4586714357798637,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013869143803484727,0.03216714756637018,0.6666132466101455,-0.0493917723559721,0.07713005996294155,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02792521733714473,-0.00529114180131325,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06895610906589877,0.03325799296045235,0.0388546819266835,0.003549902315301459,0.1343623158164961,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.013893870030735798,0.03942674038340876,0.47377644413826986,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012524070374177493,0.02881373985340973,0.6640746116825311,-0.044141929536011,0.069190070284366,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0036218982691468287,-0.07048232518352852,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029330895377357412,0.03265412349635825,0.36966862417476276,-0.03488772284178892,0.09354951359650374,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.052537475536131036,0.013620581573766938,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07835454379626104,0.048098404798519075,0.10418519839227172,-0.01623727996071507,0.17294636755323717,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08738053789470844,0.0919624388123507,0.686265063428165,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04551326150953034,0.03826809673467721,0.23510163187601194,-0.029745971660567493,0.12077249467962817,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06231811747665831,0.0682908940821308,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008743601943794409,0.026654001945470872,0.7430730686598671,-0.04367499000339023,0.061162193890979044,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.009305042911294477,-0.016827867308944235,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08679599149896011,0.04724353758084505,0.06701089296897281,-0.006114623712149048,0.17970660671006927,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08133347155309283,0.11346275365562009,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035166572908428645,0.03683385191680583,0.3403576711140073,-0.037272029648143676,0.10760517546500097,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02312934402953207,-0.010003511706227083,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05551824126439116,0.035643548351561125,0.12021511714800096,-0.014579473158103276,0.1256159556868856,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.05771631107770637,-0.08218438821515926,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00812043109167377,0.04148018810846729,0.8449043139897598,-0.07345580120539325,0.08969666338874077,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08976255538720297,0.019561609286409175,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08234899484390285,0.04079781417985108,0.044290118301516364,0.0021147404078980386,0.16258324927990764,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.02380760222206846,0.02195263799264643,0.5034452685637203,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10504361001032608,0.0446900546340424,0.019292186260504284,0.01715475404221445,0.19293246597843772,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03510330727025551,0.09133445879872043,0.3170765275914746,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04574211378164915,0.04215872145862391,0.2786548349307849,-0.037168543375038596,0.12865277093833688,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.040602649362944415,0.07823301424249925,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07400238960307509,0.04319408790271651,0.08753420566906932,-0.010944451510518219,0.1589492307166684,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.12655021392537305,0.17335949889292654,0.6570553152600204,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09261241823427827,0.0529109197780056,0.08091765235446818,-0.011443847652832947,0.1966686841213895,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.00901868811165397,0.08675809029923183,0.6399159515165806,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014192596261920834,0.08299874967168772,0.864322440390098,-0.17742052728959168,0.14903533476574998,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04747582927493209,-0.2628759804537945,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040595465631370044,0.04432729303459431,0.3603837138456527,-0.0465799720555214,0.1277709033182615,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.09890088918098133,0.09542080965340512,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03158756880935216,0.043333393420289926,0.4665145269894174,-0.05363323488204134,0.11680837250074566,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.10029431012337794,0.0837874568390061,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07735663672098497,0.037830219080854335,0.04160382782531092,0.0029585474085896124,0.15175472603338033,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.05993324536789423,-0.04659574071224003,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03896866267948754,0.035607778963955956,0.27452344995959294,-0.031058706549181525,0.1089960319081566,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06876821653357518,0.0592682719453535,0.8709804306040525,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06718683921726407,0.03535431609349948,0.05818786673436036,-0.0023420620212172144,0.13671574045574536,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.005990418524518918,-0.0011563419849518555,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07871886169815914,0.038417179770584446,0.04118742929534647,0.003166437177604578,0.15427128621871372,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.04150119856205437,-0.03011465867062129,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014183704399191067,0.03700644604891743,0.7017428241703149,-0.05859432716328231,0.08696173596166445,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07192052108846388,0.057000923651595106,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007012434399246398,0.03524482967095496,0.8424045667104287,-0.062301147424204464,0.07632601622269726,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.08825841043791612,0.042271852728871497,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006791612521611555,0.038347593981220444,0.8595250836253077,-0.06862396241419935,0.08220718745742245,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.054161433755973924,-0.026137613037361028,0.9839789607467108,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12242256787939126,0.0382704205801544,0.0015030688394490194,0.047158764562263866,0.19768637119651866,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.038178856450718925,0.05170972516076065,0.050556612065874224,0.48315413615957226 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06469313831566967,0.05988119278325401,0.2807119975040008,-0.05307108396651032,0.18245736059784967,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07750024239716859,0.06331062187450341,0.8762453150557444,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07716912212080153,0.03749742124873572,0.04031713403870688,0.00342552340979585,0.1509127208318072,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.01878246022883843,-0.012657593249082218,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09118108648158915,0.049116307112686934,0.06421566109578637,-0.005412575729425426,0.18777474869260374,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06701988554242523,0.10271885402553402,0.5879399282333936,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08853419359231293,0.047785549907162224,0.0647447589189094,-0.00544235997288238,0.18251074715750826,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02293635543783368,0.03349884013521444,0.588665895017662,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018525366605858625,0.031043630143681524,0.5510508158190428,-0.04252600513149027,0.07957673834320751,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04096185712569916,-0.020267604908556777,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1377393411520449,0.04736390333742523,0.003863674119582942,0.04459201088810806,0.23088667141598174,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.15212631730811174,-0.07822547460468968,0.10548035157916945,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019159674929120796,0.058307049354515875,0.7426509890232335,-0.0955087877659557,0.1338281376241973,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.1415848789230047,0.09035459711721004,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0040648887104999705,0.03094578694275504,0.8955683529790316,-0.06492383895577182,0.056794061534771886,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.02727068055907856,-0.05534480213311201,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014469668897252468,0.03510160897898559,0.6804238487148779,-0.08350158843876555,0.05456225064426061,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01318132471775915,-0.0674852924072117,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06510806687182415,0.03239013287339016,0.045170267956317116,0.001408620849466788,0.12880751289418152,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0407873864354402,0.02370220627479293,0.5090185993885504,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006810948731224502,0.042015550325183094,0.8713145416835453,-0.08944004106932316,0.07581814360687414,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.005325187330461094,-0.07286787575511719,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10057007894858735,0.03577842990024159,0.00521263574361583,0.030207102263564753,0.17093305563360994,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.03065035799978471,0.039515941076773115,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01656837011128514,0.03186519361365191,0.6034193091795805,-0.07923545420504466,0.046098713982474386,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.014343177298757299,-0.06863620038709366,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06081116090964131,0.027749804145549423,0.029067854626218276,0.0062375301619697066,0.11538479165731291,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0380931733505228,0.017014020460949165,0.40623350356148,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01757382458926242,0.03349186106239471,0.6001040382746592,-0.08343996364684535,0.04829231446832051,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.040635762456118246,-0.03399382209705154,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06781542638997254,0.025743602116316162,0.0087990912795509,0.01718725515525267,0.1184435976246924,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.025923269296904344,0.038681149276206556,0.19294802921843934,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020697126705201272,0.03217919055831528,0.5205178983683291,-0.08398172698841125,0.04258747357800871,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06467960660472273,-0.017103738594295464,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05175911835484229,0.02814044088161929,0.06669919612601076,-0.0035827507875558495,0.10710098749724042,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.0010320916712397907,0.005859860728485984,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030086211875194904,0.02942637903490609,0.30727297608715576,-0.02778462336634134,0.08795704711673115,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.018529694779357744,0.0008203192542326939,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003325703701768398,0.04076813289931758,0.935029553072016,-0.08350158600529049,0.07685017860175371,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.07292242802972737,-0.037367124828143215,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02894868301713674,0.028184978545762244,0.30507059119214486,-0.08437814131960797,0.026480775285334483,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.014747614871556238,-0.08670246499292224,0.8932682968953323,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06463397762936646,0.03192201262830369,0.04363737494698936,0.00185515148839141,0.1274128037703415,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.04338712136248771,0.07245584578913368,0.499126055229397,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034430272118314995,0.033663285479129626,0.3071025097809445,-0.10063353978303897,0.031772995546408986,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.025503229277272454,-0.07722923292772667,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09156480275623806,0.035191506578311826,0.009656845801809808,0.022356087790692453,0.16077351772178367,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.016458514323609983,0.05167523277736324,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011634813157549172,0.033771044691637234,0.7306578319131134,-0.054780377137050126,0.07805000345214848,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.01895315523832439,-0.016380805605036325,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0018814089147453292,0.026317891384395234,0.9430495418101787,-0.05363899534440179,0.04987617751491113,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,0.06018828215089807,0.014986322982254729,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01583467608388926,0.03125803003039623,0.612762636495705,-0.045638341160885235,0.07730769332866375,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.030093378144944883,-0.11059926382566422,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06406653829460977,0.025685706785959304,0.013073990389292097,0.013552225823156759,0.11458085076606278,329,35,364,5,log_other_mut_burden|lin_Lymphoid|lin_Myeloid|lin_Skin|lin_Thyroid,False,357,-0.030215275165076185,0.001987370753918414,0.24476730120330345,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012650763123848148,0.09292723938640463,0.8917773045044733,-0.16999737198336462,0.1952988982310609,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07615955560714956,0.15255748025604177,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08369919655140126,0.06942959960942255,0.22866321656389288,-0.05276441706323892,0.22016281016604144,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04583067723263599,0.19890794578278134,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04070100893803805,0.05598651325990073,0.46763451937659517,-0.06934026965365289,0.15074228752972899,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04398046125675697,0.13790920490005745,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013732613760915568,0.09596919055129882,0.8862829853191834,-0.20235969229767373,0.1748944647758426,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05636695781987372,0.11167832024409097,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03289611776572943,0.06748937898998394,0.6262044541677779,-0.16554623514205494,0.09975399961059608,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0927483968677288,0.07023985897643156,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04128604834775113,0.07233406128593367,0.5684543084734337,-0.10088627363063646,0.1834583703261387,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08350292544506531,0.17372593269442976,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02047994423998243,0.08860091757774737,0.8173096010341598,-0.19462471030876746,0.15366482182880262,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06917865239038311,0.08749940290706713,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017024211643061223,0.052515534733033435,0.7459633456987197,-0.12024329515916873,0.08619487187304628,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10734037718233162,0.10373168364320554,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005180930770990171,0.05318374421770462,0.9224416800629202,-0.09935151594241037,0.10971337748439072,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04731301495069179,0.0686124291292128,0.9911128933864998,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01701466137412532,0.0865294970549844,0.8442066796441624,-0.18708805829427713,0.15305873554602648,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04935328230364774,0.0870677529412198,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030854588329462654,0.051302860562288576,0.5478769216426975,-0.06998098872242896,0.13169016538135425,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08515248717231735,0.17472036311657374,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009159676915384326,0.0926391967459349,0.92128379722296,-0.1912416653097437,0.17292231147897505,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04613839850972807,0.0749128005968307,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0020634400307029312,0.06126910054643192,0.9731492989725276,-0.11836074375430804,0.12248762381571389,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06843046413553475,0.11430070105707756,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012435830957188624,0.05139535992649489,0.8089233491799479,-0.11345321515715051,0.08858155324277325,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07250600654551465,0.07554280564584132,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014352920210170367,0.14195287689511807,0.9195099052034537,-0.2646549187097737,0.29336075913011445,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08104537505342427,0.15979618842926824,0.9903757974905041,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006605719181549995,0.12974839362193405,0.959419474807909,-0.26162569270795527,0.24841425434485526,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08453423433247619,0.11239586806269465,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00021890106142673335,0.056043516337527625,0.9968853521660579,-0.11037221898510118,0.10993441686224771,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.021266900443667257,0.02566404666410159,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000599532632451103,0.0621953957276753,0.992313379943567,-0.12164528080356457,0.12284434606846678,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07458842960666423,0.12959421396193116,0.9994603233931454,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022976657405934534,0.060362963570041346,0.7036571485692928,-0.09566651760293882,0.14161983241480788,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03776906796265456,0.08769959481935508,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02598172904321441,0.05412818807653524,0.6314688541815467,-0.08040701847787061,0.13237047656429943,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05246502214589715,0.13044583187523223,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03630517132460641,0.09447312423614491,0.7009527467889181,-0.14938139456737864,0.2219917372165915,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.041168077005496656,0.138168048408324,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048011577756591865,0.0844185463336907,0.569834543324548,-0.11791275356026248,0.21393590907344623,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.059929007301250344,0.17299224379968378,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0768912889443214,0.060582027921295085,0.20505286980667187,-0.04218245621265021,0.195965034101293,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0114837887196014,0.1358483897369449,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029711513444272204,0.08941860751570846,0.7398439862838541,-0.20546344597200594,0.14604041908346155,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08930846887025007,0.1058193342872327,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0317037793051469,0.05135448539441214,0.5373295363742868,-0.06923326615767408,0.13264082476796787,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05626012081926553,0.1234533585540368,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00884793561450725,0.04921770520139151,0.857416723155247,-0.1055851477457212,0.0878892765167067,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.11959418366988527,0.14272521098292235,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05234971259615614,0.04808919903631117,0.27694179458649026,-0.04216942496542766,0.14686885015773993,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.030077568407855394,0.12603943769434195,0.8725380346331878,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002116633329272945,0.05231064134785908,0.9677429697769472,-0.10069973301859622,0.10493299967714212,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.13955806968852918,0.1674975611097711,0.9964902962886765,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024765108985707985,0.0608566346943579,0.6842532114182048,-0.09484837473789827,0.14437859270931425,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.052243981662382324,0.11652966752293936,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019499655306822348,0.043644205632999776,0.9643841674413165,-0.08773248548649794,0.08383255442513347,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08519831867032343,0.09880826647215424,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016241239071079164,0.0475675574541787,0.7329427550047736,-0.10973509208961636,0.07725261394745804,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08374513397953426,0.08404032628108464,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0037771556477330967,0.0842207082675561,0.9642490447521839,-0.16931263699905205,0.16175832570358586,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03188828936610774,0.07198882966564926,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0030702765488663966,0.09413936384772585,0.9739974083588778,-0.18810083766851643,0.18196028457078361,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.050482085423795155,0.0886486424843322,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02454286875203729,0.05408931212663614,0.6502397740474034,-0.08176946823757734,0.13085520574165194,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.031714344147201784,0.09307533203174694,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04220606413558116,0.09336105715601208,0.6514439573256812,-0.14129473814563098,0.22570686641679333,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.017955694550904913,0.11113817942241143,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037005737417780224,0.047805466316351033,0.4393029089192294,-0.1309671993988582,0.05695572456329777,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10046490582228677,0.059774562207876636,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04842936015037064,0.052903806861912185,0.3604826879948274,-0.05555287075634134,0.15241159105708263,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0637303808676496,0.12613606562444835,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021093685654512754,0.04994293807166738,0.6729764950188053,-0.11925634023025625,0.07706896892123075,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.1315355484697135,0.08770192418576578,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0015758893004794317,0.060877957041463135,0.9793602425731505,-0.11807950341515754,0.1212312820161164,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.051222758436104375,0.07423675971632826,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022344246775115786,0.035326788654437856,0.5273954072847384,-0.09177891533585758,0.047090421785626,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0897422686554556,0.07262144673216431,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001301451111587893,0.06208411724874343,0.9832851288621163,-0.12332754712105912,0.12072464489788334,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05260427183089662,0.0791003072221656,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005669543667321582,0.04303245399134765,0.8952433303321242,-0.09024966810128256,0.07891058076663938,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05790168892422207,0.06214177546948054,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009947831731389472,0.052440333896100234,0.8496352219426381,-0.09312344482612286,0.1130191082889018,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05564542247278877,0.07582626429927965,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04226383412982148,0.0500389166573468,0.3987931097700319,-0.14061513425019026,0.05608746599054731,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09294580722611796,0.05740948343918817,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012093614786568245,0.03334155127671663,0.7169930085944347,-0.05343907726889749,0.07762630684203398,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04360083172324145,0.06076981354148944,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003800766265368981,0.04529991157112193,0.9331731657031982,-0.09283756993692577,0.08523603740618782,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05743394106030372,0.05881152429363633,0.9920354344920299,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0009849004128999416,0.05051020738014115,0.9844520495161058,-0.09829271982824402,0.10026252065404391,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05433694758243581,0.06985837881158068,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02558664941462015,0.03478994679254059,0.4624597287385912,-0.04279285851108652,0.09396615734032682,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037601258086509534,0.06406990010273378,0.9372011503139762,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026115735370463623,0.037587843666900225,0.4875608691369826,-0.0999944989471334,0.04776302820620616,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05951878785668647,0.01024994448240192,0.940275458344982,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012084227278356861,0.046028173621768795,0.7930310432565919,-0.07838397268021224,0.10255242723692598,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07404582998953102,0.1090628876735795,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009558788390797745,0.04381340906589829,0.8273998562476809,-0.0765563002679808,0.09567387704957628,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.06255398082664675,-0.021246827784119585,0.9810156921425078,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0195596747411152,0.05914296362326129,0.7410181815320569,-0.09668559501864477,0.13580494450087516,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.19659175862054745,0.20893763778038343,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1138373731642073,0.1074409608738397,0.2899513493450386,-0.09733742625208561,0.3250121725805002,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.044503766458350816,0.23141408816352893,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029730700452739872,0.06270627362449847,0.6356504252552286,-0.15297964244931944,0.0935182415438397,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08712393390409483,0.1074843761195004,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021801898232994266,0.04449067139375611,0.6243604533155733,-0.10924814341787205,0.06564434695188352,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08166337893013226,0.07263701293656963,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041395059667788475,0.08024379940721064,0.6062130402473682,-0.1991139417998723,0.11632382246429535,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10528341681606455,0.07437080028996794,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009260869419075878,0.0546170508552536,0.8654358889274562,-0.1166104748699328,0.09808873603178105,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08913257941938581,0.11081633265754373,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033423241975687704,0.06212656368231054,0.5908648222962901,-0.08868628233730547,0.15553276628868087,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05765825500906733,0.14035372034076074,0.953309951095112,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008563739265139331,0.05318311992982163,0.8721504098075846,-0.09596748041280476,0.11309495894308341,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0669326411968094,0.098138976237549,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0015120992315464446,0.05763411280020851,0.9790811257923995,-0.11176752998185407,0.11479172844494695,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04826510749159313,0.07360258513754239,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010754728162199226,0.04009786859708224,0.7886647837685256,-0.0680574798554923,0.08956693617989077,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10568887534883467,0.11413601539876994,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01542951905597703,0.04700634289312373,0.7428874563647234,-0.07696126888015227,0.10782030699210633,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.007474088399293379,0.055415100406695686,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025433673383097724,0.06271747165711747,0.6852913423471644,-0.09783727830394758,0.14870462507014304,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06971254806201517,0.11211428750303419,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017921206691612127,0.07026066045928435,0.7987929623554719,-0.12017585385839544,0.15601826724161968,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03563491895988594,0.11759086503215502,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01472059461233334,0.07457860166936199,0.8436206120176782,-0.13186336294151063,0.16130455216617728,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0650850455866099,0.11217324879975342,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03268626706758087,0.06460747329339964,0.6131714801199875,-0.09429947563764055,0.1596720097728023,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06750359529513318,0.13871442305880496,0.9552990821084932,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02068443419563807,0.07629661731401308,0.7864399694017942,-0.1292762765648275,0.17064514495610364,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04094163243566542,0.08779595765783078,0.9723925976809099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018063394235668398,0.053173361314176715,0.7342426112922843,-0.1225754333917274,0.0864486449203906,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.1511996098293475,0.15048065777460976,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010259691649396815,0.0649560537316426,0.8745717630264889,-0.13793056787844105,0.1174111845796474,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07941918194203593,0.08008876701076903,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018630686786788635,0.054674881937096347,0.7334551753904389,-0.08883258543518466,0.12609395900876194,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10338143951880306,0.1421778008646069,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00562256309778178,0.044775299304383676,0.9001287230599393,-0.09362824335701295,0.08238311716144939,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07103156974436252,0.06476667040277914,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013949326071439934,0.049170985273576516,0.7767843552384145,-0.11059471036246303,0.08269605821958316,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08274584462963398,0.06357038858147612,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011182763752259363,0.05170118964354226,0.8288595496491138,-0.11280125509634718,0.09043572759182845,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.060633340866106375,0.05702889140633241,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001336154168379264,0.08505177458938482,0.987473121908331,-0.16850509321019574,0.16583278487343722,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06141670928110226,0.15323753220605293,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004421466138361451,0.04778032624195355,0.9263141916000972,-0.09833351539895537,0.08949058312223247,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08957463231720689,0.0865932590074357,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00828702238615903,0.06564798421689427,0.8996055226669066,-0.1373178853487975,0.12074384057647944,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06807028387967501,0.08888898009178975,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004829235599592368,0.04418136470895946,0.9130117231977992,-0.0916675396734748,0.08200906847429007,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.061737555860909205,0.060820554236261065,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025015886395696206,0.04432524468178609,0.5727958729365814,-0.11213698600821276,0.06210521321682035,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06052437219906237,0.0375293048743372,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005421374583774518,0.05020270809248888,0.9140542450025504,-0.09325185697857803,0.10409460614612707,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.043594933859585565,0.06641653110573113,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015222133372794742,0.05061699277344539,0.7637644587327858,-0.11470963989779363,0.08426537315220416,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.02835234395141616,0.03679240697874871,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025360736392711275,0.05763814174982362,0.6601587570844183,-0.13864828449123628,0.08792681170581375,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05878498298532253,0.0650541618406142,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021880922372787586,0.037205730571440526,0.556769725554707,-0.09500864411558181,0.05124679937000663,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.040970300815301335,-0.0071540634782847785,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014097577382465472,0.042011394847685436,0.9732463363988797,-0.08398299431397038,0.0811634788374773,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05960342645803529,0.06267490529598452,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014049164082681767,0.03910996064957032,0.7196052377450008,-0.09091964279191561,0.06282131462655208,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.023029860021637646,-0.01227829042100593,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016085832412382747,0.04889041822484441,0.7423021951394945,-0.080008098412877,0.11217976323764249,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0520210614689978,0.10518157017881669,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015407338847708773,0.04478441884142347,0.7309892899332006,-0.10343094352226055,0.07261626582684301,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05829242561653942,0.05559208624423585,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0527268117813328,0.09066733252267828,0.5611803144401609,-0.12547948499191997,0.2309331085545856,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.014686595675681315,0.0546744969460558,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02165256986495597,0.06374484720033634,0.7342666773298037,-0.10363768453959951,0.14694282426951147,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05207401787565284,0.13336525578919364,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021821656426494775,0.061762045248032166,0.7240230297309531,-0.14321472114515627,0.09957140829216671,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06628575957074291,0.06607949984772829,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027216589742554795,0.04252958634736078,0.5225492707879296,-0.11080832973739514,0.05637515025228555,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05750274589090944,0.04967889024433245,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015090142588673163,0.0699808454216113,0.8293764869540066,-0.15263722774778998,0.12245694257044365,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04375901655722175,0.07638802927403923,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006582663107063755,0.043886801412017874,0.8808413628872577,-0.0796766779285033,0.0928420041426308,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06586441813806612,0.07317706856844435,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03946616891075669,0.06539295653400048,0.5464788823475204,-0.08906343811240877,0.16799577593392215,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06122431522869683,0.15948683809366893,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005252834975738603,0.051449354801655814,0.9187271173286933,-0.10637634589719365,0.09587067594571645,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08292627559722068,0.08102889978839012,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019016668643478837,0.06905242448280177,0.7831453354306788,-0.11670560869623281,0.1547389459831905,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06568071614736343,0.13724917988364066,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044171852711382166,0.04411144806454528,0.31721143402408486,-0.042529030464176755,0.1308727358869411,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10247901709038564,0.1699182943396505,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019536336471801887,0.05064733360882262,0.6998853475650424,-0.08001080484958005,0.11908347779318383,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09778915572817563,0.1625517561038265,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0110065340831076,0.06886303865524204,0.8730882733232193,-0.12434350613379781,0.146356574300013,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06814774162044215,0.1060098634238931,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009787129051703407,0.05019892334251462,0.8455109365597071,-0.08887866359898867,0.1084529217023955,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05695548900909485,0.1043965989892977,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04064965640981399,0.05240933654199539,0.43840056623778034,-0.06236069496625648,0.14366000778588445,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07430771927516931,0.134030978494478,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01474116588142792,0.05201820179021991,0.7770182894732416,-0.1169827433924925,0.08750041162963666,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08225650792834009,0.047590523286646945,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006134746410562422,0.0347886396251066,0.8601072021676845,-0.07451168510365586,0.06224219228253101,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03472387260421542,0.04473451233035597,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006684749600831957,0.06349397681213932,0.9162014289765754,-0.1314819192128082,0.11811242001114428,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07624030242068938,0.06951077196487407,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0671233549224015,0.08381698402809369,0.423670945610245,-0.09761860797380907,0.23186531781861208,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05714547872923205,0.1735563558917501,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017964230421922682,0.058034128795599105,0.7570561976464534,-0.132030089550831,0.09610162870698563,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07351240312252534,0.06556118004346566,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07393387443493016,0.07238933347279683,0.307669258844228,-0.0683470848162368,0.21621483368609712,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07595001171580888,0.21755460675255806,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014527440684252393,0.061820747617658336,0.8143260578499649,-0.13603588468685035,0.10698100331834555,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07807131718855342,0.04718223911853587,0.9769437249386967,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06415710654949586,0.07321133755059588,0.3813413168413865,-0.07973949858604121,0.20805371168503292,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06603443134563824,0.19584941390769622,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013975810676575572,0.03327716144738069,0.6747083326696831,-0.07938194476770558,0.05143032341455444,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.02947838401105274,0.0009528710518422849,0.960515556802716,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022200760991425796,0.04312286508113899,0.6069393199033436,-0.10695858807804745,0.06255706609519585,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.056365920927463634,0.02550960494939258,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008784707662504413,0.03765059423841885,0.8156224936207384,-0.08278680724851298,0.06521739192350415,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06418922853800908,0.05549705487930428,0.977649408210028,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014841311419095865,0.05219345977309792,0.7762775685945285,-0.11742735782804964,0.08774473498985791,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07666340829672189,0.06888599795294081,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013282762887897426,0.07026922888677754,0.8501610484826025,-0.12483113887371577,0.15139666464951063,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09397214593568304,0.15131934320322973,0.9831844992504223,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037280341461703156,0.05856486160904616,0.5247469344390593,-0.07782867099077727,0.15238935391418357,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06996326781499226,0.1435983685658717,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031039438978013038,0.04051110385396217,0.44398018513352966,-0.048584981363299,0.11066385931932507,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07249206152096689,0.11516076274957228,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006865767992007267,0.04893796054960585,0.8884923359466619,-0.10305314307552406,0.08932160709150953,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06112566879314529,0.0781639085287728,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026086899852032226,0.04400426959050502,0.5536088678451035,-0.11257712414504659,0.06040332444098213,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09986471377361889,0.07599388536048285,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02218383069298338,0.05109448186068082,0.664380781903747,-0.07824217881449362,0.12260984020046038,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08662428397515444,0.1479837867337715,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00024322766184435877,0.05225111041855633,0.9962880387536059,-0.10294258619488827,0.10245613087119956,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05248254016052473,0.0733801258583214,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029463789653154767,0.04696010930630725,0.5307158926480456,-0.06283612634416406,0.1217637056504736,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07486256434647993,0.12151887990060303,0.9460639469661322,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05196116346246444,0.06024305244873743,0.3888792351503182,-0.06644632669415901,0.1703686536190879,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0805910492872654,0.17873266333618298,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027840778884405924,0.0712280093049327,0.6960880877525355,-0.1678391599064562,0.11215760213764436,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08192879415412421,0.08677366228917856,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022666411465211405,0.05568693399394273,0.6841863950046443,-0.08678604522016535,0.13211886815058815,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07832566767966431,0.14266800981019295,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010418155272511245,0.08117317386217014,0.8979361120613606,-0.16996371935636162,0.14912740881133912,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05795084301635876,0.09081378285895218,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0418021324926764,0.08127863312083321,0.6073019071404813,-0.11795071136244215,0.20155497634779493,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06802934952773342,0.1525855498548508,0.9534736034179471,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00501813526726823,0.058648509123055984,0.9318537330471907,-0.11025528605543292,0.12029155658996937,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06973022263529421,0.11429330607935237,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012177980554682213,0.048677133971867965,0.9800523180892963,-0.09445692338284419,0.09689251949378062,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0911196534146544,0.0997407021018082,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03627871943914025,0.05842703697733101,0.5349789513628307,-0.07855939922459933,0.15111683810287985,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03222859477675963,0.1169751961358892,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048761465512326366,0.05814762976675147,0.40217069714669373,-0.1630504103677743,0.06552747934312157,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.10466277797119362,-0.024104955678517496,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018185001390230653,0.05441597970992318,0.7384029263994838,-0.08876939949024445,0.12513940227070577,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.051416359928524794,0.1012158744572236,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007184005876291702,0.07616092944120618,0.9248936123362906,-0.14251001088692952,0.15687802263951292,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09695032232254773,0.15682923121199457,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018884266037307768,0.04148255726011665,0.6491707462273633,-0.06264954227408986,0.1004180743487054,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.02849337400060201,0.007654725801962546,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015680870331893946,0.0450392454402628,0.7278902954525368,-0.0728435950521876,0.10420533571597548,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06153356430446378,0.07463413706674145,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015010236153598317,0.04163222435207179,0.9712557373261146,-0.08332900202599886,0.08032695479527918,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04824613958896413,0.07630000724617361,0.99739043245727,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002482146428203124,0.05534705625334267,0.9642501241263471,-0.10630228185242437,0.11126657470883063,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04176912828956096,0.05294911679324441,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024233070918050034,0.0427696690509759,0.571285137247407,-0.05983055071640797,0.10829669255250804,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06341554885484338,0.11605944541452926,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00586240645129551,0.04184805589843397,0.8886561310923686,-0.08811460094433034,0.0763897880417393,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0866791028707688,0.06593210882117925,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014247264988784196,0.053002269860831966,0.7882088138932835,-0.11842302454488368,0.0899284945673153,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08386376841263218,0.07392276962545907,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02102957141423666,0.07888402218597619,0.7899138201477127,-0.13401667376812543,0.17607581659659877,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06593696870673754,0.14154202509461564,0.9728992869406584,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036346397768576025,0.06060915679952909,0.5490320917850828,-0.08278066909524613,0.1554734646323982,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04271066681175329,0.11016505576207765,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008168141679247627,0.041336415522955014,0.8434501604509435,-0.08941470896282444,0.0730784256043292,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04895988852606292,0.04592337186981274,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012327200137411343,0.07794837757778464,0.8744162362443764,-0.14088003913088604,0.16553443940570872,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04337644235818581,0.12273399265532957,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03986105276225293,0.05988963008809193,0.5060395160531462,-0.07785178709050566,0.1575738926150115,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07867523040545968,0.14729866684088921,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04439769140124429,0.07302389252886052,0.5435160372885006,-0.09913049125794292,0.18792587406043149,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08605815659546538,0.17138770679032933,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005419218294661271,0.07239900381202265,0.9403671887669283,-0.13688074797142524,0.14771918456074778,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09171384809348518,0.10823472663575644,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09069670346148989,0.07433836253887408,0.22311368147194016,-0.05541506499631366,0.23680847191929344,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.019655874084939007,0.2025307592485694,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03849213985559654,0.07504857601055628,0.6082872156823307,-0.109015550476001,0.1859998301871941,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.029778931172068195,0.10776685583804006,0.9537283854402375,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052037256379507735,0.0683911303933431,0.4471474123583259,-0.08238524994586427,0.18645976270487974,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.03346008447270349,0.13992588201613848,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0069517988901964915,0.07022187537155689,0.9211862892512548,-0.131069029717593,0.14497262749798595,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037568061337708895,0.08849208880768095,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02677861727214334,0.06219649253517825,0.6670122880234692,-0.09546835193484225,0.14902558647912895,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,-0.01520228659727528,0.07100733180989854,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08486002643651933,0.14494063680923835,0.558531297878094,-0.36974029608899617,0.20002024321595754,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.34839252875547705,0.17251196634468705,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021080885732372854,0.054289618694106874,0.6979831187675927,-0.08562515305275223,0.12778692451749793,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0663447309874075,0.10662336500315665,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010520065372205007,0.053735135953464484,0.8448777526930011,-0.09509613969789543,0.11613627044230546,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06337400395186232,0.08109411166568259,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030087121680347398,0.07264459259168299,0.6789570246719463,-0.11269554839685415,0.17286979175754896,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04908646892019852,0.11470783985718078,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001035547254212401,0.04259466765688258,0.980615287134702,-0.08475520431506031,0.08268410980663551,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07561797695701226,0.0842775265860158,0.9985296925363316,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003576034600495171,0.06845954715217728,0.9583651186194099,-0.13098094460380508,0.1381330138047954,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04763473138978494,0.08221916940441588,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02389009592168728,0.07627140554296213,0.7542617465565243,-0.1260210611987949,0.17380125304216945,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05069105998834117,0.10642444818558539,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017063968501248142,0.05513525077700657,0.7570965317383221,-0.12543209392478308,0.0913041569222868,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037612836633387645,0.04178720702645469,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0038620556548311764,0.042767604967579476,0.9280882495878107,-0.08019750903157206,0.08792162034123442,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.040668028949742696,0.016390003967151744,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05085101556752474,0.05268825434597778,0.3350221625942791,-0.15440957882508402,0.052707547690034544,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0973458822273512,0.057806042022738764,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05535284643111653,0.06837791822476241,0.418667568124067,-0.07904369142722774,0.1897493842894608,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.043641291311050615,0.1421201412704979,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015136893367731703,0.09988824094709331,0.8796221762115541,-0.18119306379653655,0.21146685053199993,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07054054792775938,0.14822117408863442,0.9866385240592507,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03505920513346215,0.0650217389502103,0.5900334003444448,-0.09274077514251941,0.1628591854094437,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07576381995929911,0.15593136453921266,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00019873252821671957,0.06352823212505547,0.997505468211731,-0.1246657657708373,0.12506323082727072,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.037968395323584876,0.06282724623026256,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027967770451864618,0.08643293310773173,0.7464150787916222,-0.141915830397719,0.1978513713014482,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07636931965496362,0.18083061800443215,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024439732475982325,0.04633024755828654,0.598110590468121,-0.11550165760635002,0.06662219265438536,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08744614988602627,0.07152815786830599,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05066809611080865,0.09258554400910693,0.584486022751745,-0.13130843803364795,0.23264463025526527,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06291308713915214,0.20923352121074562,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007189992148077136,0.07932484819456066,0.9278209743278727,-0.1631026791714576,0.14872269487530332,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04845699166997121,0.06721196986632932,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013162249086057298,0.04248791704295008,0.7568722091861286,-0.09667208822177299,0.07034759004965839,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06974860241904075,0.039324207010466926,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006722406792422568,0.04751054639571505,0.8875468029024612,-0.10010420479267203,0.08665939120782688,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.09502683489444393,0.06249139572176367,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029796100219353056,0.044984801427025725,0.508095838677689,-0.11821355610276327,0.058621355664057156,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06977846330919424,-0.0024754441118335566,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03150326466634032,0.0557826333246816,0.5725380354951626,-0.14114381802182024,0.07813728868913962,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.11790874335884843,0.06285692361935483,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016775623048789115,0.04949644818863782,0.7348310785400757,-0.11406070345986288,0.08050945736228465,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05693529147486065,-0.0035063888643097688,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015790442145032245,0.04773172889032843,0.740944256817754,-0.10960697349608653,0.07802608920602205,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08152082547229318,0.0436607581818783,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01970644081817405,0.04265625385310487,0.6443275471734968,-0.10354714531315024,0.06413426367680214,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07155531843609375,0.016483283016105035,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016764649424957256,0.0486365348378924,0.7304940713041794,-0.1123595734200596,0.07883027457014509,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06486075586539698,0.042604988084802634,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01765216143839191,0.04096862928998812,0.6667786539409406,-0.09817584628175995,0.06287152340497613,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.061145881355829296,0.03457356197947699,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00539691510718845,0.049704286258560736,0.9135858947592131,-0.10309050045315925,0.09229667023878234,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05064223573959244,0.0358390978034904,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05551619339230479,0.043036709179561594,0.19775333444764587,-0.14010468138249468,0.0290722945978851,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.06074278051000851,-0.012580058944039726,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00241197318157607,0.03712382338407929,0.9482272569971485,-0.07055476029639732,0.07537870665954946,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05748369642830498,0.04414699771184123,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07380435202424583,0.06124340947516415,0.22882799640406684,-0.19417804010652262,0.046569336058030944,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.07966706182203279,-0.057721572349037756,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03626790412570511,0.06411222868090767,0.5718968664884936,-0.16228024543117736,0.08974443717976716,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.0854381009856793,0.022427718741614346,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019556594550383444,0.03610407226896848,0.5883244677367563,-0.051405821994489065,0.09051901109525595,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04041230718737075,0.05658510424713249,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03348739107176477,0.050640044620043775,0.5087851256689027,-0.13302020591346148,0.06604542376993194,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.08138225297337574,0.034172438386729134,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023610571136603767,0.051110904772501686,0.6443523626980845,-0.12406885981471918,0.07684771754151165,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.061060764326545565,0.023566144088035278,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05109344442066075,0.0412712079168902,0.21639435283670944,-0.1322118464028557,0.030024957561534192,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.05381312622904552,-0.0003967950088804087,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019247685447928875,0.0350783015596173,0.5834917965854138,-0.049698582674288505,0.08819395357014626,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.02591483228718001,0.042475871942221674,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011066863305961839,0.06257238930488457,0.8596977341566265,-0.13405265618222917,0.11191892957030548,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.1351938790146345,0.14203444400584275,0.9840346955638503,1.0 +ENTREZ:7157,ENTREZ:546,TP53,ATRX,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0017626775018515014,0.05268235902863038,0.9733244120848537,-0.10178429853191338,0.10530965353561637,422,16,438,6,log_other_mut_burden|lin_CNS/Brain|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,430,0.04506164258096404,0.05427905423223757,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005917917700251154,0.09383345310999536,0.9497661762263541,-0.17895252632026232,0.19078836172076463,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13737453396423377,0.1617022305071926,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024267925130423376,0.11685389275583641,0.835662184733217,-0.2544931840684402,0.2059573338075934,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09764921332807677,0.07349328991972934,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01964873287492081,0.11250109325807635,0.8615034118053836,-0.20200065094380498,0.2412981166936466,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.038949115686049925,0.06996598431676956,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06136455362818245,0.1642263192443803,0.7089981992756071,-0.38492285349138017,0.2621937462350153,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.19263411488742305,0.14833138671556134,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06225250998619726,0.1153989237783394,0.5900881674974945,-0.16510617256577698,0.28961119253817147,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1931036503198494,0.2508460738732498,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02327294666110551,0.13844212928551794,0.8666457487435741,-0.2960312973759287,0.24948540405371766,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.057109352837516274,0.04983082113575119,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04450297269487098,0.12231387269228658,0.7163056320490817,-0.19647952560437226,0.2854854709941142,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17360979824145986,0.2241779994615612,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03486213354239293,0.12665435804427314,0.7833649479541223,-0.214671978575705,0.2843962456604909,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13610436045379654,0.15905506367475974,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03972741859828551,0.11013206359445826,0.718631652223501,-0.17725450866528775,0.2567093458618588,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10750190004120429,0.14041816517873087,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00586291178804475,0.15630273346163165,0.9701105034951036,-0.3020843583907372,0.31381018196682675,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.18443041028772214,0.1986195373439214,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0345697424037651,0.10711015693630681,0.7471744467177895,-0.17645843161760233,0.2455979164251325,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12409346773076424,0.17360371625899892,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036692519851472545,0.1586396748759982,0.8172888295560687,-0.34924402639377644,0.27585898669083136,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.18537567147369818,0.15234721348656521,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059094615777107146,0.1364970382080446,0.665461035191486,-0.20983152116709727,0.3280207527213116,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12189713751642935,0.18556444653267518,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08549767914473147,0.13874322877958606,0.538344581438992,-0.18785389707035624,0.35884925535981915,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1268603238313463,0.1987907234580305,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14718623827753244,0.2426988790204966,0.5448022783037907,-0.6253509869967785,0.33097851044171367,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.031561153568527345,-0.1542832807374124,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.197657758787716,0.20237249304660235,0.3297293241751583,-0.5963715586859994,0.20105604111056743,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.04580864158156177,-0.23808414515857157,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05087342213885957,0.10457068949761296,0.627071465015744,-0.15515149923212704,0.2568983435098462,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07097370346591148,0.10704864357006288,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002800336779461953,0.1299159378558107,0.9828213852626888,-0.25315973205218106,0.25876040561110497,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1475280621966293,0.17052998980339387,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027244625354643556,0.09670971220954809,0.7784117112893139,-0.1632926174378285,0.21778186814711561,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10896553332308892,0.13951992388648166,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01939719732103639,0.10700439666898333,0.8563094988109758,-0.23021700271765652,0.19142260807558373,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09304023901426366,0.0877415008623044,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13846087408829633,0.1590726344907682,0.38496379907225065,-0.17494364844747906,0.4518653966240717,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07176035036031649,0.20627773583782316,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054203509820942346,0.12155826343802675,0.6560795098461241,-0.29369730858168225,0.18529028893979757,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1359770681870868,0.10483025765494339,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004424064368244797,0.09257486784501964,0.9619253054376702,-0.18681484672160226,0.17796671798511265,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.01192651755953885,-0.018924330163049105,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17483363543401367,0.16275178705662718,0.2838286600501833,-0.49548681552129414,0.14581954465326677,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.19394030519739516,0.022189980080795424,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02393033151850721,0.11054583818479585,0.8288074752413449,-0.19386681344946458,0.241727476486479,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10721086321611087,0.1290870910528738,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017036448236343364,0.10400305316966986,0.8700249297471447,-0.18787011740424076,0.2219430138769275,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1575858079173237,0.18725108817508923,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018517232683131362,0.08994323045835466,0.837066845763114,-0.19572316937591794,0.15868870400965523,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.022594098891166096,0.002024676786988297,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003143773286073171,0.11612121741818845,0.9784245211998409,-0.22563797046088402,0.23192551703303038,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17071008558191356,0.19778549144101193,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03028558768421215,0.11353835510434754,0.7899027893986308,-0.1934074069335418,0.2539785823019661,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0746513162609289,0.10059504437249199,0.9728992869406584,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03263113625830438,0.10908546698867295,0.7651046971018653,-0.24755106140206776,0.182288788885459,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1635307376502557,0.1414908344431012,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07746236172443749,0.1425489272952363,0.5873677824156698,-0.2033871925685936,0.3583119160174686,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13103732931426562,0.18798204656815223,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04442537956824188,0.11730141138228815,0.7052344070428475,-0.18668157949310515,0.2755323386295889,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12361507083166484,0.16610119885145117,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05066670652414461,0.1353318530084027,0.7084557030423841,-0.3172971983856575,0.21596378533736826,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15897242244553303,0.11530241755235521,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07782737439588748,0.13439413556647795,0.5630824747007879,-0.18695562881303157,0.34261037760480656,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.05976742905122966,0.1388080016398195,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053921195434904395,0.14613845544725082,0.7124826531169773,-0.23400043860466616,0.341842829474475,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10050256373341253,0.14603846136522047,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0641905914428453,0.08563048759499489,0.45423793085181374,-0.2328995725012592,0.1045183896155686,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.19821096848973516,0.15868706926747267,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03205428519976219,0.13293214490409078,0.809664338174623,-0.22984830751640298,0.29395687791592734,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11135602311913384,0.1331095699083396,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05674571962131699,0.10591771556143428,0.5926403965374538,-0.2654245485089963,0.15193310926636236,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.23080773111711425,0.20709435135125082,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022297744672326633,0.08308149629444263,0.788641215480953,-0.14138921984594005,0.18598470919059334,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07114910715837043,0.08864884343179981,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08594582836921283,0.1206613435853715,0.476998055208548,-0.15178086105135588,0.32367251778978157,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13545790901570312,0.21383441704452355,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04786034463580713,0.09139270729741938,0.6010002912491315,-0.1322013478450695,0.22792203711668377,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07360463628121698,0.12172050078482978,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005320595832088492,0.1358451393177171,0.9687910795065676,-0.26232117148362055,0.27296236314779754,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11571867372203373,0.11064667686763086,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07688968352060116,0.11143789537320739,0.49089474868603555,-0.14266499037812427,0.2964443574193266,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10585078445138488,0.1777441802796172,0.9419198731133068,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09231131782918373,0.1454192577775686,0.5261854043032405,-0.194193354688393,0.37881599034676045,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14900970238803604,0.21902034978572793,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07401566853297217,0.09397815404494247,0.43174065773359527,-0.11113986492214303,0.2591712019880874,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07774659284945128,0.15374030126348892,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051053274081829955,0.11381359831871422,0.6541593338797894,-0.17318200405600243,0.27528855221966236,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09282055437228111,0.1363273779118166,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0536796510342665,0.13736211310809734,0.6963100243745406,-0.21695085440095233,0.32431015646948536,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11481152927345065,0.1564111010271336,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06969071145780965,0.09432970320329344,0.4607724860514094,-0.11615744330500906,0.2555388662206284,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0554121781007708,0.11855740268456458,0.9368883182059652,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05023104733175953,0.088308319814336,0.5700299333243037,-0.12375379233564862,0.2242158869991677,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0893959013148645,0.12509637901221035,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03411743927998183,0.13010990324026953,0.7933833959845626,-0.22222477968640553,0.2904596582463692,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11688081953477263,0.15043604975419145,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007093431744466947,0.07143769300165954,0.9209891353458105,-0.1336529394834626,0.1478398029723965,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.07395601013787523,-0.09484609918517525,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02039927125902321,0.0897149690797677,0.8203286836379862,-0.15635694541373343,0.19715548793177987,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.2347225094020851,0.26794689929784954,0.9788034269246562,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009178495690941051,0.1496428752358743,0.9511441990946206,-0.2856475378019635,0.3040045291838456,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07828874747483454,0.10066790196430463,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04523273985814538,0.10880628093321189,0.6779989094847417,-0.25960261330577306,0.1691371335894823,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12906158165922987,0.11544839432494608,0.9620942694833536,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07953371261872347,0.15581445320262197,0.6102274484762125,-0.22745154896613248,0.3865189742035794,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14683363892364742,0.23220759414520212,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0761790167691694,0.20933956344338078,0.7162614280027129,-0.33626128849671205,0.4886193220350508,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.24152986927548362,0.30012949926224963,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06331453319309276,0.12769527160676677,0.6204850972939413,-0.18827038432656695,0.3148994507127525,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08871555063038614,0.14199970991371222,0.9580596405456464,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00333989667170603,0.18292824504039992,0.9854486893328885,-0.35706489249095186,0.3637446858343639,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.20790298237976382,0.2414654529036338,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03628197014813473,0.13836193718923154,0.7933796049526266,-0.23631838629112856,0.308882326587398,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12413923951942907,0.14948495957616936,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10300515976924264,0.13548211225437887,0.44785225727194244,-0.16392137249791577,0.369931692036401,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11551623911237478,0.2072205089403848,0.9330843092453226,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03711599898386342,0.08683359521346809,0.6694549157863925,-0.13396334181577066,0.2081953397834975,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10830737865723522,0.13307538879652545,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015433791701803616,0.09015675914323856,0.864224198267512,-0.19306042209686,0.16219283869325277,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.010104967779702566,-0.007825290810444446,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0581810457028321,0.12894272392527772,0.6522534001286477,-0.19586159937958925,0.31222369078525347,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13652364708484405,0.17543291245308115,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006890925571907876,0.13883660349916177,0.960457091182685,-0.2666446172914925,0.28042646843530833,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12457476937809495,0.1496566445453615,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047073741672814154,0.10388737691457219,0.6508819776390999,-0.15760491888771855,0.25175240223334683,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08721489941768454,0.1368055910159839,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03054469018449713,0.0815821321765449,0.7084441586787751,-0.13018823074870353,0.19127761111769778,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11781143586200163,0.14929294199059545,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10989849341450293,0.10555474756997638,0.29888431869689397,-0.09806521680790255,0.3178622036369084,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10156254916133518,0.21310721250755105,0.8861144350754685,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031561762148901565,0.1271086136598613,0.8041167846028778,-0.21886732329234748,0.2819908475901506,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.18061519673230222,0.21511496536496563,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07345250305634458,0.10057551549779363,0.4659271043342973,-0.1247011360927248,0.27160614220541396,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12408080829265108,0.1865549541325171,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009226790742396969,0.06825302689243111,0.8925822562280906,-0.12524515896360497,0.1436987404483989,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1335277260882628,0.14214716582880416,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12878747029417317,0.12516542861297617,0.30457572710510605,-0.11781315663334552,0.37538809722169186,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14902183439504213,0.2766823588377063,0.8924777119824038,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08300546957617529,0.12938289579425294,0.521796644359953,-0.17190440106563581,0.33791534021798636,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.16759347834904717,0.24166666713563115,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09605103164351311,0.10673414581450137,0.3690977444639246,-0.11423632616848667,0.3063383894555129,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10848883260797962,0.19090509535554873,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05679783336468494,0.19893969423968463,0.7755126233636341,-0.44874834129582697,0.33515267456645714,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12629494707662947,0.0821932380258745,0.969910068419809,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008823122933859204,0.08664283533972585,0.9189766004342554,-0.1618803832205478,0.1795266290882662,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1161836042757258,0.11642566327985909,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03762876103893414,0.17117919889281588,0.8262031275739521,-0.37488560769141716,0.29962808561354887,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1738013969207001,0.1294105196122738,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0671239207109932,0.1248560112013046,0.5913589685078955,-0.1788670927749702,0.31311493419695663,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10600368068996295,0.15962105481452876,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10765364450119742,0.12959889752461823,0.40701162146384817,-0.14768179223115308,0.3629890812335479,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1512689696441167,0.25503821159912254,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0006614247589190748,0.12360699904490083,0.9957350947691068,-0.24419163749324965,0.24286878797541148,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09654752844061942,0.07596489303907154,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06609605582464048,0.08985597911798424,0.4627275310194815,-0.11093797848684125,0.24313009013612222,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07249610926107662,0.14267427612045738,0.9372623478521674,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07758429072800715,0.12328040228590555,0.5297483469539239,-0.16530246185591904,0.3204710433119333,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12761098875843743,0.20143115702733225,0.9454007145054515,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0892869884024979,0.12442660953401165,0.4737304358935065,-0.15585801894957063,0.3344319957545664,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08070305366894963,0.13116162187464417,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11281034609526808,0.11895922585208552,0.34395365031688707,-0.12156283505401386,0.34718352724455004,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10477950590310994,0.21285699392385748,0.9053547642872083,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10752156296791154,0.12341542564708592,0.3845326877917322,-0.13563121231801728,0.35067433825384037,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07938459551656585,0.16160357019993019,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05146198021435187,0.11563074577554763,0.6566935657466719,-0.1763534374799108,0.27927739790861456,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08806588098574623,0.14578396566747642,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04765812384806785,0.09002059634881066,0.5970226372195672,-0.12970023893633742,0.22501648663247314,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10883304716818505,0.16500087092242335,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2021657564107531,0.1556801044944103,0.1953659409031994,-0.10455481167175931,0.5088863244932655,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08120979999534107,0.27272385440234154,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011834920803005848,0.11096734477037261,0.9151566081256102,-0.2067926754278199,0.2304625170338316,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12181984608304104,0.16064939949421464,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06261610854769989,0.13517040926365873,0.6436259716168389,-0.20369630723554943,0.3289285243309492,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14916821207662712,0.21240880252522182,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03453300473506334,0.11460041296434562,0.7634285417163087,-0.19125245372842758,0.2603184631985543,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0513179351242038,0.07970321679693687,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07340766566104898,0.15949910822958288,0.6457740900483858,-0.2408370944109635,0.38765242573306147,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11122529822097921,0.18594725796569928,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12041507163710781,0.13295023339921713,0.36602213776635173,-0.14152315898872436,0.38235330226293995,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12005870850319067,0.22716933638405057,0.914684777397777,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001275046388931256,0.10351326069159081,0.9901826777034289,-0.20266653128734727,0.20521662406520977,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09916252438847581,0.11189630045464825,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10797143339784991,0.11424432732324805,0.3455907769771769,-0.1171124659905224,0.33305533278622224,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13956247690784518,0.24851787386928045,0.9073272983575541,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006456805953792834,0.1519966423357165,0.9661524950467195,-0.3059202257353445,0.29300661382775883,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14930251115431942,0.15354551413769518,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007539370127529923,0.07151111854912222,0.9915971328953612,-0.14164497107799667,0.14013709705249067,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11680908605390083,0.13197928132529424,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006559591495409534,0.09677368774733167,0.9460166662880933,-0.1972228787388157,0.18410369574799665,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.05436096889290219,0.06463739935278584,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08226348854096804,0.14639619889665456,0.5747081675184988,-0.20616595102376833,0.3706929281057044,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15419602409269967,0.23657624998556656,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008400033596177912,0.10551590706087464,0.9366164344332696,-0.19948715314845253,0.21628722034080836,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11792925354679326,0.1382570103031585,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014332528476505122,0.06665999703286012,0.829948033999472,-0.1170008376250802,0.14566589457809045,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10221172380354694,0.11096900445520207,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1196106252064165,0.11365583368126474,0.2937093705997941,-0.10431382542151033,0.3435350758343433,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1425425587192603,0.2464000683714086,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04969452986727833,0.087653596691254,0.5712991565673861,-0.12300037587504259,0.22238943560959923,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.044322362210319884,0.09430284849867357,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035036429097670733,0.08318492907073066,0.6740066419271273,-0.1288543184280936,0.1989271766234351,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10299743835438734,0.1156175393054435,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05240733292300884,0.11147867739490237,0.6387155540014905,-0.2720423554629589,0.16722768961694123,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.02176546104652432,-0.06810390956193904,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06669024936440893,0.08599259113326226,0.43881011019616245,-0.10273214721567842,0.23611264594449627,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11364336962682518,0.16260003812185622,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054756079788827156,0.1294808126850834,0.672765894574849,-0.30985886605385116,0.20034670647619687,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.00037866641469055685,-0.0431073058960067,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037554402965836974,0.08419581899249139,0.6559851343701499,-0.12832799745660478,0.20343680338827874,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11018871220410457,0.121087978573437,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07017369241045833,0.12785289768463315,0.5836252158280294,-0.3220691644502657,0.181721779629349,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.015610388819573714,-0.07386239467393874,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049142001885241315,0.11345706298008902,0.6653188130999668,-0.17439083118448323,0.27267483495496586,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07041816827684634,0.09409969790251879,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08917603766981298,0.06862441670639526,0.19506360633878095,-0.046027623355943556,0.2243796986955695,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07202792821433489,0.12982747012323098,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0534954324484584,0.10632139387516623,0.6153352798744258,-0.1559787224836925,0.26296958738060927,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10564504090223022,0.1582000829033467,0.9560640930990785,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06318109752147633,0.11460213724127119,0.5819507116007647,-0.16260775810827335,0.288969953151226,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1410949341307098,0.1923941424540837,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09451628831758783,0.14329362556661185,0.5101628159288423,-0.1878004687216655,0.3768330453568412,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15531219321825057,0.2693842436132915,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03202260295410491,0.09293433128696271,0.7307266862584135,-0.21512159931769664,0.1510763934094868,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17425115653778928,0.14297990558866042,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002181099065569776,0.0576903545375497,0.9698739376643102,-0.11584249705926218,0.11148029892812263,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09186783746398408,0.09247239913296755,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06465398221532076,0.1047440549673911,0.537668078678371,-0.1417125033879673,0.2710204678186088,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11446483034006621,0.18079423065325662,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08786305273092308,0.10668037478566862,0.41100325259132964,-0.1223183655291762,0.2980444709910224,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.17886866296189452,0.2530291977443315,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07233617147830103,0.13001106578927604,0.5784818258568127,-0.1838113181794505,0.32848366113605254,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13272062974431928,0.20289708553421074,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017875601676741473,0.10180645446326583,0.8607731380555088,-0.18270323046658166,0.21845443382006458,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11721416786177222,0.12288598555681027,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10657839625634304,0.11548503785229754,0.35702638033489376,-0.12094994803738117,0.3341067405500672,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13248237331126367,0.22904216851711373,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02103834040314115,0.10378856551451683,0.8395434172906485,-0.18344564217425147,0.22552232298053376,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.06018191366046278,0.08528635879586549,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02593137752142856,0.16066398537907692,0.8719171994423933,-0.34247117575647085,0.29060842071361376,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.20070977416667907,0.17622949614798755,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04187565494140483,0.10933263136907573,0.702060432291371,-0.17353123287117936,0.257282542753989,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.154677280168388,0.22216312274875638,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15583635839273446,0.17519239103842155,0.3746435245129446,-0.5009999865747008,0.18932726978923192,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13484644821455202,-0.03587287741614728,0.9159127256227925,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019863780056372984,0.10959894961555816,0.8563362823744451,-0.1960678073259932,0.23579536743873916,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11763785285898316,0.15987680074358063,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04359917988060625,0.1450923454976163,0.7640693643274389,-0.32945977060914666,0.24226141084793418,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1543432624919067,0.11785013086203838,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09928051072657423,0.11597764697334872,0.39285986688640373,-0.12921837087467647,0.32777939232782494,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1456456932825738,0.235192423493431,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025476401401862768,0.09190548016570907,0.7818706249388615,-0.20654835775666147,0.15559555495293592,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.02652172468869608,-0.04998578515972886,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1784559261082214,0.23261903309631607,0.44376327978308316,-0.2798495343732019,0.6367613865896448,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.22715407841522944,0.3400261482773094,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008590320837306258,0.11313776046558117,0.9395415548990245,-0.2143134231849894,0.23149406485960192,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10454293014266551,0.10700084738796299,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06412101509171933,0.16893673376386636,0.7046204496640345,-0.39695976233136876,0.26871773214793016,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.21282600065998966,0.16432550734910012,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02385385806923892,0.07712201675128866,0.7573695626433753,-0.17579947030046417,0.12809175416198632,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.06175086496294489,-0.09019314070152719,0.9659382371888035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09440695216374465,0.10524402526129695,0.370629298199209,-0.11294457371215377,0.30175847803964306,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08443310443233173,0.16574517015642443,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010307078982780939,0.10427743244667734,0.9213480263415375,-0.19514006805057085,0.21575422601613273,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10449863363230495,0.13165266767627878,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1091627600993081,0.12563212436855056,0.3857915910742675,-0.13835734968529345,0.3566828698839096,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07169364171373561,0.16230879424965478,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0072361613022060714,0.10211933208973704,0.9435700741304651,-0.1939591015895625,0.20843142419397467,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.113116656094649,0.14217911185354215,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10003627261373599,0.12014393603936029,0.40590217715746635,-0.13667102170199172,0.3367435669294637,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13098784126384982,0.20376008045429658,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10209678426317448,0.1184603210697506,0.38964803468361264,-0.13129345588183583,0.3354870244081848,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1331257252813677,0.22915118881031651,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03544072554524868,0.13944489992086226,0.7995993699805496,-0.239293281467649,0.31017473255814637,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1492609257884399,0.1959018594751898,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09614930240549098,0.12154753297209354,0.4297234760520915,-0.1433233552170315,0.3356219600280135,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10482812971759342,0.2029995552077733,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03719237605311729,0.0731502890986791,0.6116273632788654,-0.10692814789316807,0.18131289999940264,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07098520187084767,0.10243280337988153,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013490120955337827,0.12649875340100317,0.9151645021341707,-0.2357374192682008,0.26271766117887646,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12487772411507429,0.14810895591751655,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07112425228655898,0.09920195795602044,0.47411427246734383,-0.12432320709165971,0.26657171166477767,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13345241896432558,0.2023306522094362,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04249436536808487,0.10573146242911337,0.6881198395864886,-0.1658175080454949,0.25080623878166464,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.0841256708098753,0.12921348660795223,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03654595446850296,0.1437162214333023,0.7994938845368986,-0.2466033999326392,0.3196953088696451,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.20275041873132116,0.24979384509138455,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0825053686080803,0.10176555786764555,0.41834255131869846,-0.28300362637690624,0.11799288916074563,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.011026956922275557,-0.11024272640224897,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04082687398647811,0.09756943078550268,0.6760114578547102,-0.23305793225308705,0.15140418428013083,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10011664162089873,0.0674762795047555,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04665885503247167,0.08971217901665011,0.6034911653881972,-0.13009186466462974,0.22340957472957307,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08170779602222242,0.15196574988546063,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0514723222324165,0.1347879592508246,0.7029011936906353,-0.31703123591865345,0.21408659145382047,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13923468496630748,0.09742401789060404,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013841801860852602,0.1004888128422477,0.8905611477952792,-0.21182461964614094,0.18414101592443574,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.004864213827505042,-0.013443540094048839,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1160880284370241,0.30052725063127383,0.6996409218281849,-0.47601003918220436,0.7081860960562525,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.43337977816193474,0.6067621227976956,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09244798723725449,0.12145713514739694,0.4473327625401905,-0.1468465688080985,0.33174254328260744,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.169621272071354,0.27185006579600896,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09933725802694758,0.11395114704442023,0.3842405010059369,-0.12516901828001237,0.32384353433390756,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1728847900135688,0.2792194642892617,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01005630434931987,0.10903224786435949,0.9265926583372084,-0.2248713773021415,0.20475876860350176,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.055221215626040356,0.0439998119458457,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10485502826423036,0.1120361067762336,0.3502916674583012,-0.11587824030441464,0.3255882968328754,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.14988548637086804,0.24994175346095326,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022891997585772546,0.10850329949241073,0.8330874872617235,-0.1908809425546558,0.23666493772620087,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.061277367786281386,0.07159304171363032,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017406096157001408,0.11328299557725584,0.8780175633473208,-0.205783789733602,0.24059598204760485,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.06592879888797362,0.08071503614948033,0.986092730312823,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1315789473330392,0.153905788515795,0.393467138454623,-0.17164586766858864,0.43480376233466705,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09346277263960959,0.22243719955982044,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04601399282865017,0.1305063565062295,0.7247217049587412,-0.2111093174104359,0.30313730306773623,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11731008913613851,0.1346342267325381,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062328673417965164,0.12376808070572917,0.6150235631790757,-0.1815189020177677,0.30617624885369804,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1596024796759891,0.21734575972755454,0.9559539934434115,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053236376859171604,0.11984762287069768,0.6573098906338137,-0.2893598756814566,0.1828871219631134,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.04488900314586509,-0.0031038812055861342,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08705814950591073,0.12546837407350386,0.4884578703797854,-0.16013933984055895,0.3342556388523804,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1728630598663154,0.27418811273308347,0.9404802865694325,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016116777745498,0.10666502365600865,0.8800298392588515,-0.2262679512467997,0.1940343957558037,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10282974278543645,0.08171710941098825,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03751540966451506,0.11010829616504472,0.7336260982072029,-0.254450510395724,0.17941969106669392,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.13739015207163546,0.0929771883489372,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03432088151515717,0.1323325790246986,0.7955917139251621,-0.22640044794500436,0.2950422109753187,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15171574431986093,0.191109589395095,0.9735235918682278,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033078697971062165,0.10958128136212864,0.7630246238506747,-0.18281807946081913,0.24897547540294346,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.16552433843684686,0.20331650425920766,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1815427798404023,0.08839963695629925,0.04112501764514261,-0.3557075323216514,-0.007378027359153189,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,-0.007200603102621889,-0.19051979078869782,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11665050078716505,0.18186286766172124,0.5218802209814171,-0.2416552844220216,0.4749562859963517,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.15576777115940987,0.2621222011293477,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04408478705295735,0.11898868907730699,0.7113498361445728,-0.19034644247191387,0.27851601657782854,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11127857239899097,0.13487225540107622,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09977144245017873,0.1095038422497947,0.3631723422677705,-0.11597276462851579,0.31551564952887323,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11436212185412727,0.20882904417049308,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0782552893722669,0.13263525114077757,0.5557599043124879,-0.183062363964269,0.3395729427088028,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12880891887699017,0.15456384786088054,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1009221112441573,0.10984189271213396,0.35915330192045924,-0.1154881220437692,0.3173323445320838,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10392550901625104,0.2083091642053818,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0243311533301164,0.1388106223254756,0.8610094349966124,-0.2978155081475019,0.24915320148726913,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11733543681739042,0.02746209967342969,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09715434470277541,0.09869871591293838,0.3259631808951865,-0.09730162841046154,0.2916103178160124,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.11035471015423341,0.19680094326883996,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08321364475267835,0.13183634584925794,0.5285356772896261,-0.1765300072967,0.34295729680205667,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1310845705678187,0.17335337705374088,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09356291616422534,0.10537350079359939,0.3755010942837881,-0.11404370209454089,0.30116953442299155,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.08712577423712817,0.15908028498923732,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03345815069928345,0.10026846015907384,0.73891685371526,-0.16409052875868882,0.23100683015725573,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09364123437384171,0.1126064338882028,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07530440541356674,0.11934645999991574,0.5286765591931893,-0.15983170352401005,0.3104405143511435,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.12110431170206701,0.1807413641047018,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016690316112273486,0.08472564029640157,0.8440051309733123,-0.15023593697101606,0.18361656919556302,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09241123322454396,0.10354974592296712,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11206594719710103,0.09887151065305676,0.2581900865037848,-0.08273046569823203,0.30686236009243406,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.10317462730477192,0.2144248976520381,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12325802797012071,0.20211654150652728,0.5425644394124212,-0.27495149681845377,0.5214675527586952,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.1593858607011699,0.20861618589239503,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.145337609143034,0.09616788564902447,0.13206949446043176,-0.04413212826083546,0.3348073465469035,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.05932143872550823,0.1948083693352913,0.7380396089280018,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03942182494011781,0.10859943123694923,0.7169323850943901,-0.1745405137325852,0.2533841636128208,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07940518742604119,0.11316752169601911,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10815440331057964,0.10179310878030108,0.2891121894250055,-0.09239813520020969,0.308706941821369,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09208005527654003,0.18099117325814562,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02599178597950798,0.1043626307810295,0.8035394833655202,-0.17962321860762082,0.2316067905666368,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.09822384660000448,0.12009188858032474,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11400787774777764,0.11129448874023286,0.3067180417566936,-0.1052642567469848,0.33328001224254006,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07794943197768685,0.1823809872785036,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02921341377515896,0.11043568534946055,0.7916063599560725,-0.18836670834111532,0.24679353589143324,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.07086319401651975,0.08521235333609119,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.116129014913634,0.11839176515969385,0.3276655593950888,-0.11712615654198719,0.34938418636925517,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.22312977982467389,0.3868177646430907,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01550287247407356,0.09377585928925924,0.8688367430786832,-0.20025984528725715,0.16925410033911004,229,8,237,2,log_other_mut_burden|lin_Lung,False,233,0.01843252351555352,-0.03472640323813575,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10666210632901821,0.1287132706448947,0.4078016496928364,-0.1464109906108401,0.35973520326887654,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13100498282172565,0.2581990419764447,0.9246299615143487,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024511179421869568,0.09708488263988738,0.8008119709015431,-0.16637490242981176,0.21539726127355088,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10533388712827474,0.12726622588577502,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020423355317815486,0.06903678133786112,0.7675179785825523,-0.15616190013448633,0.11531518949885537,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06580482308437137,0.05594406049527558,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12442985575891578,0.10714792076134524,0.2462470468383389,-0.08624194212081372,0.3351016536386453,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15180902948419334,0.2777352916390648,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.116255290452054,0.08430781357615827,0.16871847215053015,-0.0495088096368196,0.2820193905409276,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14866488538579417,0.22960783697753995,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05616921833755086,0.086393238754378,0.5159802257013166,-0.22603363384568273,0.11369519717058099,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09046983131592606,0.047074704946553594,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06743204317934298,0.09322724158498633,0.4699319552358505,-0.11586923281856157,0.2507333191772475,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13762105910573605,0.1868728199880079,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0017961213568235537,0.085341988966604,0.9832197915098548,-0.16600135079638945,0.16959359351003656,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1305916220999796,0.1085818870034497,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014821680563444779,0.06619367546242053,0.8229437319924143,-0.11532681432892018,0.14497017545580973,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09069419475341021,0.08570894091646866,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10922214088896447,0.12016711858984383,0.3639646295952391,-0.127047706808183,0.3454919885861119,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13731405438058453,0.23087129498187775,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02273997434183584,0.06911785139991797,0.7423333151371587,-0.11315796858173602,0.15863791726540769,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12573676621859914,0.16649491796790852,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06695724226912994,0.10629475810944165,0.5291222400063775,-0.14203708666408865,0.27595157120234853,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13777736056177423,0.18249336629266522,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06374707621945808,0.07573731145339133,0.4004886564766681,-0.0851658980789585,0.21266005051787465,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11173972466384563,0.17680004745121272,0.9219399112464703,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027454149660671442,0.0761756032150356,0.7187421659586064,-0.12232058390255751,0.1772288832239004,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.110814948963156,0.11096760808291983,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0835812952704835,0.12577512275335254,0.5067512842199524,-0.3308774728417764,0.16371488230080938,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.00982262051779768,-0.06880574336040605,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013089063286198362,0.13691828536038575,0.9238901471953391,-0.2561165464402798,0.2822946730126765,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.03089412684655002,0.03409879723306335,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04194617517105211,0.06366138447643824,0.5103590469740369,-0.08322338694332859,0.16711573728543283,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05587595956102646,0.0653327278478842,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03758522607994836,0.07129033732764348,0.5983505990763462,-0.10258420912280414,0.17775466128270084,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13610904066166563,0.18614102025323892,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044854387699486686,0.06677502887014639,0.5021643991047553,-0.08643715100314414,0.17614592640211751,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08872515577754538,0.12681868898125814,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04302499430051792,0.07254348890983338,0.5534693421304622,-0.0996083589601855,0.18565834756122135,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09377109428103265,0.15319706695444293,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09955918913367734,0.11163330930291844,0.3730379838894323,-0.11993167738992325,0.31905005565727795,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08612828913043083,0.1750846056901294,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021063969710753992,0.08442303954788724,0.803103939333192,-0.14492668505556078,0.18705462447706878,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1300438965757556,0.1695130438701191,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03733942348236168,0.0669715777506889,0.5774833254458271,-0.1690174121108606,0.09433856514613723,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.026528246586891284,-0.006823016431873371,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08014224510143284,0.10574907832054065,0.44900508897232905,-0.12777918067717897,0.28806367088004464,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.16265571816985272,0.2238235296959699,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02976165693192759,0.06996136729510864,0.6707830770468608,-0.1077947877051377,0.16731810156899288,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10468165337871653,0.125703109117972,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027372054736005593,0.06295884374216866,0.663980714953949,-0.09641618781080295,0.15116029728281413,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13711289792345482,0.16765675237797464,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008863708418506916,0.059481440655269266,0.8816191460512648,-0.12581476033143144,0.1080873434944176,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.054442229154568825,0.042957624769452814,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00871362102752823,0.062210490275537385,0.8886808824314159,-0.11360322600227449,0.13103046805733096,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15089291932755758,0.18035132971540593,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015577906827006854,0.0734084385654874,0.8320571343687211,-0.12875609071813354,0.15991190437214725,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08595756340881922,0.09440587138369515,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03546595319691814,0.054158581904308355,0.5129549686815326,-0.0710194152481725,0.1419513216420088,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1307117244307673,0.16385962970754425,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020151223046193364,0.06069937995241957,0.7400829401469017,-0.09919451333298909,0.13949695942537582,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11621751257900112,0.10843385382543058,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011495221348707183,0.09974865231506834,0.9083138052980303,-0.18462830368078267,0.20761874637819702,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11124881198280456,0.10377399792493892,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029174949483979286,0.09031883738409727,0.7468550461817645,-0.14840788851150255,0.2067577874794611,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13387447538674233,0.14831332783014403,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028750693876602066,0.07633838297410146,0.706663297532621,-0.12134409353608253,0.17884548128928665,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06436495030409303,0.09373001677582056,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08962369183586642,0.09625206371810294,0.35237013991554667,-0.0996249204474471,0.27887230411917996,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08962071115610927,0.15850364571393544,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049370986579927105,0.07358464440955521,0.5026622521916888,-0.19405143603662037,0.09530946287676614,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14896379419539713,0.10613431804984205,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02464321126001007,0.08324959429374516,0.7673783022745035,-0.13904024221255146,0.1883266647325716,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11558936474441588,0.12188297262230069,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00907060694214376,0.036481991926243046,0.803778372206081,-0.08080066735511358,0.06265945347082606,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1756073488517283,0.18689110270010573,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014024560482307569,0.04840460309166461,0.7721749309830368,-0.08114746606302271,0.10919658702763786,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07078637721955149,0.06063612764525479,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05678366319880876,0.049478336565106786,0.25183068191191454,-0.04049951361137405,0.15406684000899157,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11198853374084222,0.1390465309106338,0.8597986894695818,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027245228740154146,0.0596753379756713,0.6482478691324183,-0.0900870596615693,0.14457751714187758,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07671333724132322,0.08516345365367649,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04590393311209043,0.059818417493962564,0.44332369334948873,-0.07170967497501751,0.16351754119919837,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09257265980273846,0.11285538088583712,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03141339809894413,0.06528146469037652,0.6306496186512388,-0.09694152877990975,0.15976832497779803,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08909969497795459,0.09937780713288458,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03199982310719719,0.05858236860230392,0.5852214804481849,-0.08318349384198961,0.147183140056384,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12278727762321157,0.11636786331776175,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028215107446272293,0.04827849818038391,0.5592792408641429,-0.06670897449880633,0.12313918939135093,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06540827420712515,0.08516101231372727,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0070689749101870165,0.055454034727070126,0.89863176184399,-0.1161014331475982,0.10196348332722417,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07924335267943859,0.046167788306200636,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047681382153481514,0.06610159133240807,0.471143609584008,-0.08228605902278639,0.1776488233297494,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08680618842708336,0.10150379801659432,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01769462031424093,0.04445826576134269,0.6908481175776249,-0.10510744841212229,0.06971820778364042,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04778802368009805,0.012992619702787806,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012001896599636366,0.04612320988140657,0.7948386790549586,-0.10268829985092082,0.07868450665164808,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06722661664890746,0.024340117194424037,0.9733769568556405,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0028961656058265166,0.06705910157530003,0.9655739737311844,-0.13474624158195772,0.1289539103703047,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10974767980425738,0.09443005558274939,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0939620673722372,0.09616247010009432,0.32912756873179494,-0.09511038798287552,0.2830345227273499,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,-0.06496599857441104,-0.0036072669095568014,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017888722192788493,0.074063016504295,0.8092706801688708,-0.1635097359510401,0.1277322915654631,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.21701290718529914,0.19644227066885103,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018146486925442386,0.10217253001954497,0.8591260546806976,-0.18274281116071797,0.21903578501160273,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09465424621428625,0.11467566709094351,0.9839478606341621,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04041687318006179,0.08908712567995866,0.650317520737834,-0.2155779477167981,0.13474420135667453,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12789104453041117,0.13258319332503274,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0614908698812242,0.08469867169640034,0.46828482358103574,-0.10504172652864374,0.22802346629109216,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11651796529762513,0.1640957332932653,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09110130820261136,0.10132026546796565,0.3691419569245199,-0.10811228676141099,0.2903149031666337,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.17679763394290599,0.21980027804264193,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004575524463195579,0.08259873195864892,0.955852975496194,-0.15782821833152336,0.16697926725791454,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09762116874807383,0.0735908108337199,0.9953510323348796,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009971548173604855,0.10500655427045782,0.9243953093288273,-0.1964899437538564,0.2164330401010661,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15664319531548127,0.1846406540601642,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09048405488752115,0.08052693123974022,0.2618655000632715,-0.06784616058907861,0.2488142703641209,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10614627632584199,0.16611993265263328,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01857698541097939,0.0711389467152559,0.7941274974874399,-0.12129478902274297,0.15844875984470175,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09345942192894832,0.09096012523147828,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02286464231991075,0.052876041906675046,0.6656797684647326,-0.1268283098749217,0.0810990252351002,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10583853846352176,0.05371654561337127,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02348443935265031,0.0691942311412668,0.7344953440305169,-0.11256367967622731,0.15953255838152794,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.023607097830419352,0.046065199702345724,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038536056136577214,0.08103942005076206,0.6346857900065157,-0.12080180315097147,0.19787391542412588,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11907368345225727,0.11756774964505433,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05126963638046806,0.09583562835496409,0.5929778046057699,-0.13716019019025508,0.23969946295119118,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10993603372003416,0.1704320243584924,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048476737936604855,0.08168425003833792,0.5532203491571543,-0.11212897136468274,0.20908244723789243,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09075634083066547,0.13388163070522507,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03233972552078259,0.06400563012421981,0.6136642148820056,-0.09350668453441768,0.15818613557598288,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11300215047123048,0.13450237746347435,0.9555250172093686,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07807334724881967,0.08790952767033419,0.3750388770139904,-0.09477236094105349,0.25091905543869286,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08347158016861092,0.1477647801190663,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002669766403423342,0.08182999572709788,0.9739900167548803,-0.16356203755365872,0.15822250474681204,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.17750257568213562,0.16908821862758894,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04578880331461801,0.06198544549390833,0.4605401017670788,-0.07608556579855913,0.16766317242779513,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11360130080564586,0.132477934878582,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02050530946862417,0.06536143216244586,0.7539030963327555,-0.10800684762984611,0.14901746656709444,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12646760512727695,0.12638538441443622,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043418454281944914,0.05398697301991738,0.42175759476241037,-0.0627295006888581,0.14956640925274792,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10267402524143662,0.1272115974498125,0.9282753503874777,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0487833088801416,0.06474097523821906,0.45160333644756956,-0.07850891996582504,0.17607553772610823,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12075833058684607,0.14103516257459747,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028341564020261504,0.05686547007380237,0.6184905301060182,-0.08346602620267257,0.14014915424319557,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09357649803292523,0.0986673155077808,0.9572656024379023,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061832280354478485,0.09863036656745601,0.5310922902405342,-0.13209249674487178,0.25575705745382876,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12511566767619228,0.19709821022418186,0.9462574637850627,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01096326042180277,0.05874104465090301,0.8520439658041483,-0.10453204175492083,0.12645856259852636,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10986856223756157,0.091967759268591,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06041203473985563,0.0909157736094203,0.5067807406719214,-0.11834448564642544,0.2391685551261367,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13293772610606072,0.16814769091493076,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020916581889806725,0.06546913094824311,0.7495309105772117,-0.10780733010481228,0.1496404938844257,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08383370520887756,0.0750876343914223,0.9643073530246201,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06810222819156228,0.058629347261606235,0.2461326023966966,-0.04717345712601538,0.18337791350913996,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10363116421877444,0.14500201948203847,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04770266388183472,0.06110121311580752,0.43545210392700273,-0.07243314769784737,0.1678384754615168,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08002907725131009,0.096910386640936,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02515406846025694,0.05917976873913278,0.6710425226198033,-0.09120384301195059,0.14151197993246445,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06206970266032445,0.07948879548731883,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08342399180674052,0.07016316779810491,0.23517639627380646,-0.05452922837647793,0.22137721198995897,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10274278836846816,0.1750359738441138,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06584196200955503,0.06365060779731421,0.30158888646256776,-0.059306411244135715,0.19099033526324577,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.0520889736984472,0.05494477575808764,0.8896367821404172,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05106491671756166,0.06903264924615005,0.45992231483410817,-0.08466550367463516,0.18679533710975849,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08169461544264264,0.10880555111902103,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03884012468310985,0.05152682800128646,0.451441774663599,-0.06247074926514837,0.14015099863136807,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.054764566758715404,0.05271058241736314,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04310586876693336,0.059510163335428065,0.46929640120207106,-0.07390165702458801,0.16011339455845472,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08304365552082063,0.11982517419239916,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0116533855135342,0.06870123933181803,0.8653953285571909,-0.1467321952912516,0.12342542426418318,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09004113157620648,0.07678503564732067,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09898631420212212,0.1248899963845633,0.4285085618702028,-0.14656954809157505,0.3445421764958193,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05380010332108056,0.12580353283600296,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01787623895402945,0.07598045757893117,0.8141216867782778,-0.1672672816185981,0.1315148037105392,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12060797895471716,0.13170484304551672,0.9769437249386967,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04165134363074981,0.07345325205758169,0.5710153767020206,-0.102770765180402,0.1860734524419016,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12453518919233994,0.1528510801859041,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004409366628575938,0.05989369869157171,0.9413512888466864,-0.11335225763219331,0.12217099088934519,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06248756599267268,0.04880146563533077,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08125106784995745,0.08759502817040363,0.3542115857596071,-0.09097627859652527,0.25347841429644014,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09539451521210572,0.16172957351827766,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08775632337729879,0.06539839599086675,0.18043225014750072,-0.040828511157510086,0.21634115791210767,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09706213768110564,0.15007242910465182,0.8012048953586696,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02615695284701337,0.07160896469498984,0.7151078939946012,-0.11463896021789062,0.16695286591191735,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09960992436838088,0.13516396543527362,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0725375477936082,0.06825885925914126,0.28859519153401125,-0.06167146437539438,0.20674655996261077,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11526522033472625,0.17184597423127704,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032763771101798796,0.07555112773435027,0.664776928763884,-0.11578313301487642,0.181310675218474,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12770551525721288,0.16724310130381978,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021552653864842355,0.05059227649050757,0.6703421950778603,-0.0779207262189709,0.12102603394865562,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12082368334609521,0.16130589138396983,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02748410340707389,0.07385378822695902,0.7099928768754589,-0.1726937372986846,0.11772553048453682,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09764840229439742,0.0904444775399082,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04640158099736971,0.08936493514166761,0.6038953901374584,-0.12930571616646344,0.22210887816120287,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1267307259646905,0.15937216294517317,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028760818200130246,0.07608247458669694,0.7056239727577891,-0.12083080797821649,0.17835244437847697,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10218737438492291,0.1335427722961792,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02224770692044884,0.05261124850035984,0.6726275978728637,-0.08119532987869915,0.12569074371959685,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10401107850681673,0.11865677521823187,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08135522425532055,0.05453196593212731,0.13655344227304786,-0.025864283348806125,0.18857473185944723,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.0989757468237469,0.14194661322116156,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02735852921173547,0.06607466710994751,0.6790657927315036,-0.15727303259591208,0.10255597417244113,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04469042472973015,0.007926699474035348,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04189506266694584,0.063282688867717,0.5083498809076022,-0.08252991677917983,0.1663200421130715,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09354778387911782,0.1066951677278183,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04749532110857671,0.08133072534467815,0.5595791611933658,-0.20740593822068343,0.11241529600353001,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04457643122259426,0.0046090615540821285,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03753997921665159,0.06282599602282259,0.5505113442959296,-0.08598706117448288,0.16106701960778605,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10124605509187964,0.1186074784238239,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03412170686678955,0.08315354188537223,0.6817817483282509,-0.19761630428485352,0.1293728905512744,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06780744278937019,0.06081610625110646,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07519926668479916,0.06418275760694654,0.2420688329762759,-0.05099540738686363,0.20139394075646194,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09263562096003047,0.13214939761186575,0.8491564414671808,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05059719852955405,0.08427053104828855,0.5485855272236884,-0.21628799456250192,0.11509359750339382,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06037983139596437,0.0352012776099129,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010798675421584797,0.03986158519866968,0.7866105642525846,-0.06757626419898244,0.08917361504215204,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05032126012461909,0.017231110299247215,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02550503010276456,0.05334730955233604,0.6328560478916673,-0.07938523314807035,0.13039529335359945,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06782784227335552,0.04701431722393923,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02551832669755873,0.055002219901194575,0.6429465366154556,-0.08262578353459413,0.13366243692971158,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08803456349764531,0.09476537386609837,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053153582836774675,0.06279116450807568,0.3977948168963761,-0.07030497262453134,0.17661213829808067,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1077635783864807,0.12800725603700785,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06510431190739988,0.0807272483868325,0.4204708951898598,-0.09361976257480822,0.22382838638960798,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13262680177303926,0.19964804035015463,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051169769637317404,0.09143686847305563,0.5760667533964322,-0.12861131558426703,0.23095085485890182,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1308463048872085,0.17256844406086705,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029209421184419746,0.05688557014640254,0.6079139018231483,-0.14105653171164068,0.08263768934280118,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09004553037330186,0.04458896864201786,0.9536302663534211,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008559384015839775,0.07030749971355627,0.9031671032988315,-0.14679638631917316,0.1296776182874936,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10302350493555992,0.08856799735835043,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062323359185768194,0.07725440927305503,0.4203233917335579,-0.08957249824240923,0.21421921661394563,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14737525445270067,0.17456574330347438,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023731848278510043,0.07500604691856183,0.9747756943322912,-0.14510199382148944,0.14984836347719147,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12185131293668144,0.11542440426145704,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06452378589259458,0.07712257424422424,0.4033169745643186,-0.0871128605089016,0.21616043229409077,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10114367975009214,0.13753970731123458,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03613281610745105,0.07255444182001067,0.6187630321415154,-0.10652207251541965,0.17878770473032177,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11528436851815653,0.1219123851652998,0.9572677741452639,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011173265321285123,0.08338964554611798,0.8934819338357881,-0.15278555372928335,0.1751320843718536,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08550820729919595,0.09845944810182493,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10147335921428119,0.11008208885748731,0.3572146621091298,-0.1149675330510726,0.317914251479635,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14953128547619235,0.22813712838503772,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027762483993358778,0.0855409530176937,0.7456973774760716,-0.1404261867389649,0.19595115472568247,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13299270266873128,0.18175017109798788,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10280408977746382,0.10871864200322284,0.3449500215743644,-0.11095602438169473,0.3165642039366224,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11542567713941576,0.189631088192035,0.906393006043464,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0335063013144443,0.09172736162438203,0.7151029805712599,-0.14684594491546238,0.21385854754435096,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11427005682914763,0.16080462945824345,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06636547769382488,0.08552739939982344,0.43825399564333356,-0.10179654422418478,0.23452749961183456,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12667878852970987,0.1950842122454125,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024787055024176826,0.06389681679214661,0.6982884103102773,-0.15041951878776214,0.10084540873940848,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12893389911149133,0.07788526170365623,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06815989010819351,0.06127065307370468,0.2666470114015415,-0.18862885066836182,0.052309070451974804,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.02883518941250011,-0.03158688526551105,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0977215400501938,0.09084709223243388,0.28275176417004666,-0.08089994057920004,0.27634302067958766,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1429659341176256,0.12554732288199097,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035572770021972136,0.05456926897991429,0.5148677491868404,-0.07172008198387356,0.14286562202781783,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09472332425499276,0.11159904076552819,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07238852636026101,0.0876148932094974,0.4091978985590209,-0.09987787827298912,0.24465493099351115,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.17858363328023152,0.24812502616924156,0.9256805126137099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029038487134395132,0.05156940416490855,0.5736995024636846,-0.13043307336445362,0.07235609909566336,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,-0.03730944935988621,-0.07438495272561284,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012480207193885167,0.04469598920048133,0.780223396643279,-0.0754000273078315,0.10036044169560183,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07267015914260218,0.06445400425301902,0.971058846433733,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0672281682667833,0.0590527180536424,0.2556470454291549,-0.04887993904549351,0.1833362755790601,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08630017300978786,0.15862930752775634,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03146951089463829,0.06489226719687818,0.6279889952832709,-0.09612018474964779,0.15905920653892436,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06483427059155031,0.0708169063687037,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017187029537406195,0.054817693558816535,0.7540481848500951,-0.09059426920919726,0.12496832828400965,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09969912251175848,0.1304732500765187,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05619271565594462,0.05676604436498987,0.3228478868061907,-0.05541938600610875,0.167804817317998,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1049467591523521,0.11679482757567511,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048442983977378506,0.06085737291398062,0.42652020267249735,-0.07121339455918697,0.16809936251394397,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10636951026720999,0.12514239287362375,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06321772056918303,0.11112017035436925,0.5697485676149175,-0.15526422385789124,0.28169966499625726,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13150316424636257,0.19402607191306337,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033566008893326775,0.08571773353934603,0.6955806638688037,-0.13497024366850868,0.20210226145516225,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09842963399132042,0.12179932657814047,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002982338056897976,0.048703770063926635,0.9951174337063123,-0.09605847562822604,0.09546200801684644,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06691078700080119,0.05751599423121501,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06449087993524202,0.09987953428988465,0.5188689648740783,-0.13188998224786386,0.2608717421183479,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11573137623265893,0.18125941630317502,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.069899851144133,0.06901398080950435,0.3117778671713184,-0.0657938637937367,0.2055935660820027,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11365429438803994,0.1664188641379283,0.8990379896110621,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025371697364266206,0.09249056406038005,0.78398922066064,-0.15648114008752723,0.20722453481605962,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10959983460901562,0.12505710390728936,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08696370640027455,0.08528148493268925,0.30850234324679804,-0.08071480410148292,0.25464221690203204,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14937518645594328,0.22797498034673094,0.8969323713769235,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004852825427258832,0.06931601994057861,0.9442221146688645,-0.14114040281548046,0.13143475196096277,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.04317268252310954,0.03923170319016523,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023691533881534284,0.08030941773876567,0.7681512928050442,-0.13421101151068288,0.18159407927375143,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09762021714843887,0.10466862574833194,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061761611517775115,0.08998147660529292,0.4928879505532654,-0.11515791540923417,0.23868113844478442,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08150346563099824,0.15967366777925776,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04573192064766604,0.07743223610964362,0.5551329727465639,-0.1065135758505856,0.19797741714591768,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10534943641444716,0.14394073196576973,0.9497080900134104,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008577723012449844,0.07575614011715423,0.9099090520594071,-0.1403722717751971,0.1575277178000968,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.017561000464446398,0.039537754780478336,0.9890962952045544,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10145697845854892,0.16300614273115552,0.5340413683665897,-0.21904198139621986,0.4219559383133177,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.2974558699890219,0.3944898403655964,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07545005955563501,0.07125924083018143,0.29035322107420874,-0.06465823442308306,0.2155583535343531,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11818494669984382,0.18552317332331017,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06555586389181389,0.06677961938404035,0.32687982194254916,-0.06574470057453091,0.1968564283581587,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11860009640888089,0.1675312358748955,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008848165171549169,0.07473248821987338,0.9058145075005876,-0.15578547894708866,0.13808914860399035,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07568607822957014,0.049893706027553365,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07998534230440454,0.05794975532052622,0.16831373237771027,-0.03395414483933462,0.1939248294481437,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11015478528923041,0.16491588488236716,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024108450444009995,0.07532176106923004,0.7490876464351954,-0.1239874781672965,0.1722043790553165,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06872578792875324,0.06270603503578366,0.964192424193284,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006007141115466747,0.0756407876102347,0.936742669824677,-0.15473033243506695,0.14271605020413347,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.080209805375884,0.05291158428531362,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06991780257832092,0.07137916377287024,0.3279380779769978,-0.07042628115500707,0.2102618863116489,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07132067910186388,0.13472441394042892,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00011348220324694329,0.04957806443450309,0.9981748675321652,-0.0975927416755584,0.09736577726906451,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08140561167724349,0.024131224426114685,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04937001080176682,0.06566672460522613,0.45261691160169304,-0.07974240533432744,0.17848242693786107,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13624697999394322,0.15885152076026354,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014870224488251964,0.06672757382539843,0.8237712295579112,-0.14606845816429453,0.11632800918779061,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06461741468326093,0.0457236983786784,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09730276574035168,0.11171582335954418,0.3843081436354887,-0.1223503380393354,0.31695586952003874,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.15134710243480742,0.2490468957569414,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028197843600519,0.07772770281698033,0.7169713905740964,-0.12462859279844124,0.18102427999947923,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10692861295041287,0.11994565984261336,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0849034472335634,0.08749923774525128,0.3324926279931403,-0.08713555826385454,0.2569424527309813,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.11173418255731739,0.1718481437334262,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04135451790286798,0.0855062179243,0.6289153598736961,-0.12676585748109265,0.2094748932868286,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.14615374447177223,0.1910600067307895,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04107727577866772,0.05081015842993133,0.4193356803762832,-0.0588244988048033,0.14097905036213873,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.13229204304671316,0.15383698231479367,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0891047267595858,0.08343910364245612,0.2862376705675682,-0.25316078919109186,0.07495133567192022,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07672845152299039,-0.002873260818659967,0.8779577391674485,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05288379396068406,0.11029693158449698,0.6318797457828655,-0.16397951717419984,0.269747105095568,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.12226212053998156,0.13566751330256208,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020216690307795004,0.05601308479934586,0.7183522695878948,-0.08991495943043352,0.13034834004602353,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08472561016799819,0.05941484634587466,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016824572983154734,0.06186207533561934,0.7857923262981887,-0.10480722853872645,0.13845637450503592,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.09111609679181436,0.07980040252236519,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05674212472889325,0.05373691699777645,0.29166832947437427,-0.04891417579466744,0.16239842525245393,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08906875697439123,0.06817054984263857,0.8799526010712531,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03840174962648746,0.06283524008406897,0.5414628999284529,-0.08514346622702322,0.16194696547999815,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08440650704091486,0.09613430447078347,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011248457703018785,0.05763023676487043,0.8453529812817056,-0.10206279934444189,0.12455971475047946,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07748555641632845,-0.003924276652954659,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04217641148598899,0.05515201227974691,0.44490311577228336,-0.06626221710428104,0.15061504007625903,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08395512240679616,0.09551052992681201,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0433678344563702,0.06015740008465134,0.47140710366450345,-0.07491227346874577,0.16164794238148616,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.0969718072754186,0.07734650829107458,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04697411085773387,0.06149273155798905,0.44539897553934793,-0.07393149535287875,0.16787971706834648,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07319710735736215,0.08016258606289466,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018818722094466025,0.04953936448235956,0.7042494209293841,-0.07858444641464235,0.11622189060357441,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07394188476727781,0.059216778043184544,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01455931245781618,0.058154645441896094,0.8024469834592278,-0.12890164988488403,0.09978302496925166,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.08661436530933699,0.03294188396640665,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03623479047249377,0.0482295265995032,0.4529341697574527,-0.05859300466724282,0.13106258561223036,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06826104819515644,0.07719565663872735,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009414080079995614,0.06309482206758568,0.8814701926639938,-0.11464151994873818,0.13346968010872942,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07741251366295632,0.07502330957058984,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07048742779060865,0.06713433550122884,0.2944049816586937,-0.06151057141468419,0.2024854269959015,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.10307823322628354,0.057499948933375726,0.880884562535511,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06888546478952919,0.05737010813378558,0.2306017153309378,-0.04391433327672831,0.18168526285578668,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.054686864224564896,0.09448808900682763,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019685636509134127,0.04658372981685164,0.6728344171253717,-0.11127750355355892,0.07190623053529066,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.06431520075793647,0.02239490325198907,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03244196791554455,0.06233350583813109,0.6030451632257774,-0.09011674950758597,0.15500068533867506,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07916369464925033,0.0738991160814765,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009134506823529221,0.04664873281967412,0.8448590645843129,-0.10085418128945961,0.08258516764240117,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.07418997623925644,0.03416960026199916,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045259680714702384,0.04425833513757695,0.307130653494901,-0.0417600483509191,0.13227940978032388,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05937765325639043,0.07487366323570256,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02777538961595172,0.054411232573334065,0.6100151751146908,-0.07920673481190518,0.13475751404380862,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.05208156603526468,0.04754964583238421,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000440358808361817,0.07165990478729886,0.9951001329046332,-0.14045571150415506,0.1413364291208787,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.1685308178009357,0.18816857813770174,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0033752708560701927,0.06614205452198418,0.9593277145824597,-0.1334222698327637,0.1266717281206233,379,11,390,5,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,383,0.046484022669068766,0.0028673853918848784,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1127921796474633,0.1467957100347482,0.44296178876637404,-0.17625223947273388,0.4018365987676605,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06447098139674048,0.2580407403766135,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14347135946689468,0.13017148673448806,0.27139451606977905,-0.11283954880335526,0.39978226773714465,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05674780881536847,0.2614159114198242,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07221178720082841,0.0835803541985524,0.3883859341005318,-0.092360017543754,0.23678359194541082,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03113035366518046,0.1264209209366998,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11144014088322225,0.12043871372149072,0.35566588067746785,-0.1257066942591098,0.3485869760255543,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07125342131267699,0.2751702869894134,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07324990179999777,0.08878959770366891,0.41012891552804787,-0.10157903350129943,0.24807883710129497,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10434444956147135,0.19470275538501536,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010132267128034222,0.12812584537428368,0.9370286601913234,-0.24215072221632505,0.2624152564723935,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08660221014526098,0.10867365797001892,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04992811709115956,0.10145268165093932,0.6230365242346334,-0.14983474674893932,0.24969098093125847,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08979380496563105,0.19711976222460328,0.9584620018167673,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08725038357358583,0.09461602303607046,0.3572943005573195,-0.0990509287157893,0.27355169586296096,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11127323071080354,0.19377138123635262,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11125125940502092,0.0766968042975392,0.14810147622441017,-0.03976666367536105,0.2622691824854029,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.052012375113030404,0.17935415166941204,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11972726928890139,0.11224822558106964,0.2871173245785008,-0.10129229015648773,0.3407468287342905,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06948952079133283,0.2671156004679543,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11102532312055444,0.09097077007411956,0.22338726713872986,-0.06809839505054663,0.29014904129165553,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08119117388757119,0.24493350335041206,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10740617449062617,0.11657803176968883,0.35772548521777514,-0.12213888147231255,0.3369512304535649,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07007060898597364,0.24296981503655324,0.9120511198404183,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13689348538275442,0.09369536403723472,0.14519575629893594,-0.04759502634546489,0.3213819971109737,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07271914158505957,0.2547899482297646,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11490635955640754,0.07949583269515323,0.1495251710051348,-0.041622920341539305,0.2714356394543544,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08734563424511567,0.22046115152360068,0.7663649588223891,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08533277203124942,0.21204919846509454,0.6877020621808458,-0.3321973954425701,0.502862939505069,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11364475149934615,0.18076566168176833,0.9632925656593531,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07605654078948829,0.15625878405607724,0.6268518695601961,-0.38373398898757216,0.23162090740859556,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08076434848402766,-0.05145875202673256,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1110990044635716,0.06935633445049914,0.11038736898340033,-0.025465350167808848,0.24766335909495205,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0370506961899871,0.15434820961831527,0.7002905874282662,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0793601950775244,0.10210776295247437,0.4377275079242594,-0.1216925402052337,0.2804129303602825,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06802313527775163,0.20795033091424334,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14900269448181983,0.08147561985650646,0.06856182454632226,-0.011424835779843462,0.30943022474348314,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03536373304415142,0.21746675573206412,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09051247298979193,0.0806100742255496,0.2625280692109339,-0.06821077630846492,0.24923572228804877,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.041960244727874595,0.18458535330952927,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13994504882508543,0.09749400794087609,0.15235507037628243,-0.05202308761636695,0.3319131852665378,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04554984629054269,0.22682951751283653,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03187894341451848,0.11840893784715648,0.7879657061423812,-0.20127121233982426,0.26502909916886125,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.055687278843723154,0.17061637831108514,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1709535340314092,0.0624573163315141,0.006620533730658547,0.04797351837171747,0.2939335496911009,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.020342785103635054,0.1491239980313318,0.1564101093868082,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020857932057087088,0.10974865852368111,0.8494151311278696,-0.19523991742835956,0.23695578154253372,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10145239669477957,0.18360623442361013,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06012512289254955,0.08236543578468522,0.4660520835410128,-0.10205447715387413,0.22230472293897324,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.054594569796341086,0.15051495609175025,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10520155836172643,0.08318564260413377,0.20711272688051524,-0.05859304939595675,0.2689961661194096,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.13213579828893057,0.2494216331874186,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047206751092065916,0.07712370555847078,0.541006138991724,-0.10465175123248092,0.19906525341661274,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.02733511181574482,0.09732140172011511,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08232128814751968,0.07872546368691537,0.2966709872897282,-0.07269111593408617,0.23733369222912554,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1429525402502438,0.22755332904477152,0.8839993607754738,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11284449961646627,0.08681853927772687,0.19481641884961515,-0.058103372419129704,0.2837923716520622,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05531505629749497,0.19955086924545704,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08019309153557228,0.058295162849292266,0.17010390823098673,-0.0345915399724086,0.19497772304355315,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08965062888731358,0.18185256097339222,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14442751962784545,0.0795411790075667,0.07054620606373146,-0.012191048291717937,0.3010460875474088,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10792033011575325,0.2731888315449906,0.6147044826936338,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09733920105045377,0.1061525924881058,0.35999618353220664,-0.11167790460314184,0.30635630670404934,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.043198608352072315,0.19909941567898826,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05172064065667746,0.10644106738127372,0.6274364869764991,-0.15786447926590969,0.26130576057926463,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05956873532917901,0.17545635932945788,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12578430085949432,0.0800411899236997,0.11727004516426572,-0.03181880104115889,0.2833874027601475,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.02134901056632403,0.17347633957545558,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03616533012955293,0.12122239320406762,0.7656802439308042,-0.20252458948550817,0.27485524974461406,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04258161215453818,0.1520796532689727,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04089740462444368,0.07593327265085675,0.5906207787585454,-0.10861710557525553,0.1904119148241429,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07857476035348636,0.13415539961592618,0.9533037295212146,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06408964291737484,0.10764435901526842,0.5520993153263143,-0.14786478828343605,0.27604407411818577,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0711987804065023,0.15386339301506596,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09970724090886394,0.05515576957289601,0.07178952696007973,-0.008895846834990506,0.2083103286527184,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08034880041993485,0.17405820479104409,0.6200927802057812,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06785399650073062,0.06013501576424952,0.26019581054871493,-0.05055335134510876,0.18626134434657,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06164637823413617,0.14186960483271366,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06518987968549939,0.07168609813447241,0.36398236262693107,-0.07596183782291596,0.20634159719391473,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11028185433583557,0.17858044489904637,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05630381030058769,0.07076741075892103,0.42697171654605337,-0.08303898882215786,0.19564660942333323,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05673188808530916,0.12400473173622918,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08733887802312387,0.07915301175030143,0.27085416243905014,-0.06851537887283288,0.24319313491908062,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07799493650319012,0.18223467942760999,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0927634485408563,0.06975453128136366,0.18471806021004322,-0.04458496559502528,0.2301118626767379,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0671648472450694,0.17214515535238648,0.8047111541643488,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11348439709968229,0.0920134383414004,0.2185479006631731,-0.06769236092919058,0.2946611551285552,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1251918007528755,0.2510244496489427,0.8332532350933084,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1298328130007047,0.055165353326541114,0.019332960362090413,0.021210854606579316,0.2384547713948301,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04601395935175007,0.18265608453520019,0.3170765275914746,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09920965155820284,0.06556098824448539,0.13141890670928708,-0.029881571608929694,0.2283008747253354,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08143973879899001,0.18584846099639307,0.7364614878814166,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13049543542648612,0.07912774569979118,0.10030584652879149,-0.02530907198502405,0.2862999428379963,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07444161093412593,0.22101956972632072,0.6805365895261084,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06605500285016613,0.055731979308339445,0.23699784364697227,-0.043682656252982316,0.17579266195331458,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.055956873269359,0.12340059366939332,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09708826253429631,0.05606177766883457,0.08448021013445055,-0.013298777777019197,0.20747530284561183,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0683471008726331,0.1457895671293807,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07918694287508414,0.08813092330631822,0.3697329902159452,-0.09434504608815923,0.2527189318383275,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09241472862274197,0.19568421686724902,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05038992631088724,0.06250195061605425,0.4208480501844759,-0.07267797536975631,0.1734578279915308,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.04229620567832923,0.02093635915324428,0.9279699506567693,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006721533850450087,0.06744529812242352,0.9206909397290257,-0.12607994252491417,0.13952301022581431,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.18722169069899658,0.1736106063483589,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042214350227654504,0.13839274326008197,0.7605822958822851,-0.23028441745835032,0.31471311791365936,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06369875000655408,0.16675024964181814,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05232980060390419,0.08923994512301767,0.5581134785538489,-0.12338588001302334,0.2280454812208317,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04331669791899433,0.13339262313479014,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06654643799559654,0.08992185015626061,0.459931289537013,-0.1105119306616163,0.24360480665280937,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11662482672221886,0.19884891257553639,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11984943454267105,0.11863188941583097,0.3132977420016672,-0.11373971841836256,0.35343858750370466,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.15599123756108796,0.3225363950210596,0.9010715492787081,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11808654174044714,0.09910170979855662,0.23450438693433076,-0.07704719980936797,0.31322028329026225,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.12039087711081285,0.24313488677274622,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13619946305155306,0.09228911369668016,0.14119616742700358,-0.045520106636555174,0.31791903273966127,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05349393380157535,0.28742223290914537,0.7596261630193029,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044782024814790364,0.0998197778475424,0.6540688751718734,-0.1517656106564393,0.24132966028602004,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0960620990169147,0.1656500761947433,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.193743176006145,0.07935331427246474,0.015284950442646397,0.037494518441713004,0.34999183357057695,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06385144257713006,0.2880965847505074,0.27083021565564086,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0669059698184505,0.05107825025462024,0.1913821236244992,-0.03366838055614829,0.1674803201930493,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11766176078058532,0.1645052371574167,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08149860031230857,0.06932031032425434,0.24078538789878534,-0.05499482191483285,0.21799202253945,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.02296567875487062,0.08585823003422322,0.8476072767807353,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12046775634090116,0.08188252433195271,0.14242529138813534,-0.04076097899490856,0.2816964916767109,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08372257181436464,0.21884749167479642,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09310574218096608,0.10532433034319585,0.3775085442285103,-0.11428049462436364,0.3004919789862958,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.024965125874500414,0.1842301598581433,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0063276261787796675,0.09029815844865592,0.9441873695520404,-0.18412695526160552,0.1714717029040462,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06491465806817653,0.07330295816769265,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12054928479804215,0.08130657728478355,0.13936439410876247,-0.03954539641824599,0.2806439660143303,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06271285512975215,0.20785495817706157,0.7554902334520308,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03988487106750145,0.07737907368628794,0.606673151895831,-0.11247645747825612,0.192246199613259,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.047868925603473625,0.10893961803553232,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056021909302798795,0.09899029493721417,0.5719216307196857,-0.13889245360256913,0.2509362722081667,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1544467585488251,0.21258773544674134,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034013501698483495,0.07372735683099967,0.6449348110115205,-0.11115750516159006,0.17918450855855705,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08711607420497712,0.12283652617325612,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06062632622555818,0.08382473963786465,0.4701684270988895,-0.1044266795522882,0.22567933200340456,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11814563659817576,0.18698866032927133,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11663478476981826,0.06504185275223023,0.07408559103007734,-0.011434247648224621,0.24470381718786113,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08734441884172045,0.22066578700466785,0.6242218401318658,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1477865180753901,0.06800290803250901,0.030654991967715435,0.01388709386137188,0.2816859422894083,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10182583952351376,0.2649455804789779,0.4195505624822847,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1261909382536517,0.06150870464710575,0.041199382978959614,0.005078762691095931,0.2473031138162075,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06325249258644014,0.20628364169084035,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11398718955622789,0.13137463265737717,0.386376982284908,-0.14469274308343993,0.3726671221958957,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07750545022907043,0.27986025370259554,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08245166417820132,0.06909733627701538,0.23383961322015334,-0.0536027165813944,0.21850604493779704,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0961873215372992,0.16941784921403136,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.098324787854685,0.10311617751750006,0.3411950978824311,-0.10471354089065592,0.3013631166000259,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0941115235914938,0.24281588748769214,0.9043732915535342,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10887217118653134,0.07478482739925056,0.14663901960599673,-0.03838102163159532,0.256125364004658,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08345247376223722,0.19576135646428303,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1267064202426961,0.06511832357535066,0.05274548027731344,-0.0015131851358457793,0.254926025621238,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08299905162103571,0.23041190164555317,0.5404408711479688,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14652700275205088,0.07601720869443475,0.05498794485344029,-0.003152779613663975,0.29620678511776577,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04677985814272686,0.21409184980290932,0.5490494418196339,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09745836383732129,0.05128607503974197,0.05848873878320033,-0.0035251987293781345,0.1984419264040207,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.018079581940175657,0.13811189392035692,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10373717312252641,0.08431333798272285,0.21965538152286712,-0.06227789499855328,0.2697522412436061,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07016830995603378,0.2242572355053235,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12665417721275438,0.06513554562592304,0.052904748952731964,-0.0015993388134663278,0.2549076932389751,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06997862795725308,0.18331643138434364,0.5409607190737244,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10720228551548179,0.08132310260800428,0.18857468670067923,-0.05292493447492978,0.26732950550589335,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08693292805850304,0.19724686477376818,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14399843283944985,0.06457670240627034,0.026599627247003006,0.0168452930692215,0.2711515726096782,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.036955554225722165,0.1781449988126562,0.38460444642387953,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12368029277365206,0.08311653707475983,0.13793974440387533,-0.03997824447085904,0.2873388300181632,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0647112764605942,0.2136473241301812,0.7515207213987387,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08769613633406334,0.055724863371763446,0.11675102749073268,-0.02202751131225425,0.19741978398038093,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05664536349676291,0.15897811798766107,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10701051049848775,0.11103966582158831,0.33607445660081814,-0.1116293645980288,0.3256503855950043,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.0070759971120545745,0.1362019789036281,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06806505636039098,0.07840543424779167,0.38612196617473904,-0.08631720176319624,0.2224473144839782,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.043967482611057776,0.1772181159060078,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09144898655387233,0.08938061949173909,0.30718129960673546,-0.08454368540825567,0.2674416585160003,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08058846125204595,0.20466652289710463,0.8959335604367346,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09184778628260101,0.07643549796451911,0.23058480309324153,-0.0586556181022255,0.24235119066742752,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06680491527858003,0.15319398125131026,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11048548646977353,0.09764239005016584,0.25886194174522875,-0.08177481805055072,0.3027457909900978,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07220030292588683,0.2346467437670122,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15661159308151146,0.07938877354567735,0.04957506777142357,0.0002931153225673999,0.31293007084045554,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09557447089780798,0.25501434186507393,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08428186132547338,0.10445835197114904,0.4204839302249258,-0.12139924243843656,0.28996296508938335,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06225537736232146,0.19280009820782426,0.9279200175745067,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08122088050455728,0.06763606590621038,0.23088916200846793,-0.05195622240129935,0.2143979834104139,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09446705535811636,0.182350893296907,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1067135482864707,0.10859483377953057,0.32666999218420434,-0.10711239146223664,0.32053948803517807,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07268995514733531,0.2417794985842744,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06096164321195219,0.07541316381642832,0.41960894914395197,-0.08752875970361002,0.2094520461275144,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06233108278916277,0.13394454431030767,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01670879016653845,0.07226076632618478,0.8173166317386179,-0.12557446336306605,0.15899204369614295,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08727558997381171,0.11073493776440763,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13856031560423024,0.08560828587507441,0.10674515203711306,-0.030004537256792335,0.30712516846525284,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07483682660495508,0.2527635464053682,0.6917085852004926,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10220812868627854,0.0853193374991525,0.2320157339143189,-0.06578777760638518,0.2702040349789423,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06592811181632731,0.20851524910011032,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0949919592971632,0.061202764869525854,0.1218441237168148,-0.025517813202827533,0.21550173179715393,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05245146645072815,0.15780719428882486,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11695600546335315,0.06778312060761361,0.08562204212947895,-0.01651065182209628,0.2504226627488026,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10754512651524407,0.20875319547260493,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060173381675875076,0.06142010552131819,0.32813372348804104,-0.06076433999533906,0.18111110334708921,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.045631585767501044,0.1074861230381625,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07451386607766611,0.07680337920520068,0.3328432135152761,-0.07671390565749273,0.22574163781282494,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06772499927641001,0.13276122827839662,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00417605453171838,0.0775789585296707,0.9571116876677542,-0.15693096132600123,0.14857885226256448,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05749559008868811,0.059398972263207984,0.995747388821315,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08485925255482167,0.0707431491613867,0.23139748790010692,-0.05443577487647201,0.22415427998611537,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07000367904313606,0.15912479821392186,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017925158457544638,0.09425899402133343,0.8493232365128696,-0.16767315478540543,0.2035234717004947,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06524776634152782,0.10358375594645537,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0575156450172617,0.0645463796338833,0.37370355822647805,-0.06957778845685861,0.184609078491382,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07392036282576199,0.10601388740701205,0.915824547329523,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006763009904063484,0.09979315069206193,0.9460199943736649,-0.20325821584116813,0.18973219603304117,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.055281320464902285,0.0668337456657873,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09499674988951048,0.07327840916489586,0.19598055601184763,-0.04929026780402937,0.23928376758305034,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.046453207255743735,0.13182542059124447,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13734357790795015,0.04907232789001524,0.005509059462132881,0.04071893876496856,0.23396821705093174,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05942679102938584,0.1755565491564619,0.14061387141611192,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09621007824996929,0.07177101114654888,0.1812349317925264,-0.04510883509983395,0.23752899159977253,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07389475897602188,0.1752437240656717,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14439903869171103,0.08083644781903267,0.0752007898728499,-0.014769945865546086,0.30356802324896814,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10055802985015869,0.25512690488849765,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04211944291061581,0.1252766361566005,0.736979484721257,-0.20455338232825154,0.28879226814948317,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11615466644445654,0.19101054512543678,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09982299608158746,0.11589226667928229,0.3898337519087989,-0.12837177129211017,0.3280177634552851,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06941648702350531,0.22005071291990752,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028161812774816455,0.08044722676000425,0.726569591241071,-0.13024078579684484,0.18656441134647778,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07120399538481513,0.09796636859577294,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057021273947998156,0.07566605793349267,0.45176884827659425,-0.0919670837998168,0.20600963169581313,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07129248076464911,0.16223049061891703,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04325273975492641,0.08176411644252397,0.5972556741106138,-0.11774284748949101,0.20424832699934384,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.120938946581761,0.18210773887262888,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1265481373735863,0.08067762873147477,0.11795157039355973,-0.03230812843393688,0.2854044031811095,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10053398880856848,0.27006035383880994,0.718572191699215,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060781110683277365,0.09094452374469582,0.5045079884140387,-0.11829092780971508,0.23985314917626982,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.062391368092715706,0.15359489356927244,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1359343864223096,0.08226085945016272,0.09963011359586921,-0.026039300209760058,0.2979080730543793,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09706452153250239,0.24882726666706587,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023927071131380304,0.0968749712364255,0.8051092747885933,-0.16682216657924642,0.21467630884200706,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08070440557887909,0.1088607041322897,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08999565860480416,0.11172358605607094,0.42124695364572473,-0.12999087251356609,0.3099821897231744,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10834501175713784,0.23964686170438473,0.9282753503874777,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06913159517934604,0.09848246796372126,0.4833195264126766,-0.1247828437327929,0.26304603409148497,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06836663645640889,0.17379036643619003,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05340374564646248,0.12048670331963843,0.6579612115937222,-0.18383758221310997,0.2906450735060349,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06887751622924737,0.17208219382773016,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06840591367816456,0.09777392609483093,0.48477455871288977,-0.12411338859907364,0.26092521595540275,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06161133152648331,0.1622262034610966,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06995830794591633,0.09000191928250353,0.43768160176747006,-0.10725771882050737,0.24717433471234002,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06904354428533409,0.197817809811659,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12462681142600862,0.06045372161890098,0.040235800828331524,0.005591923793031514,0.24366169905898571,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10551663300302432,0.23860038361094935,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02725625844301772,0.06581133671983214,0.6790963318345298,-0.10232790712425101,0.15684042401028644,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.01716284435339601,0.05327405742817501,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22950409310221984,0.17526362517398372,0.19151483233208974,-0.11559436188207464,0.5746025480865143,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.1611205428446621,0.3416287724702098,0.8125064948355263,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12289919553714451,0.07565933939175161,0.10549346446227664,-0.026075933234194104,0.27187432430848313,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05236929498855974,0.2023550365962159,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08994431353881993,0.09348588155381135,0.3368748037810486,-0.09413172194794361,0.2740203490255835,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11442743672875291,0.28017965952344354,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061644529846743894,0.058672642417363835,0.2943828800161665,-0.053883368357907906,0.1771724280513957,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.03239166026497646,0.014199588948922037,0.880884562535511,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11443840458633314,0.04518737436787219,0.011906471963919644,0.02546333595090243,0.20341347322176384,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05486148469590521,0.15956009082702557,0.22774355289058826,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0817202751364226,0.06675876642595227,0.2220050334990744,-0.04972940318321398,0.21316995345605919,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05412818888642131,0.16634008643417322,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10737512463031318,0.07603865566946623,0.1590989922820534,-0.04234688736485334,0.2570971366254797,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03904363268947769,0.1473629710949584,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0674234809862242,0.07918652979145434,0.39529324884934425,-0.08849677376983892,0.2233437357422873,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06457025504423575,0.16027388567395537,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13118449618423053,0.0666830442135647,0.050201415160740795,-0.00011608320813577544,0.26248507557659684,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10477089983719622,0.22177908471787047,0.5271148591877783,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11180261206591532,0.06948385357599138,0.10880627778156628,-0.025012830908209577,0.24861805504004023,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09721439839042859,0.20925394245862625,0.6983913976492675,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09595976841558151,0.12432918884780661,0.4409139240312103,-0.14884750941081376,0.3407670462419768,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08695497880141553,0.24418803639230155,0.9320838159679753,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09851237694090295,0.09301752950383216,0.2905381251415821,-0.08464146166287304,0.28166621554467897,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04540715096654278,0.17236283017293863,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08773441004652902,0.06359040131847325,0.16885702813724554,-0.037476678250039475,0.2129454983430975,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.043793624999291444,0.13684197542132953,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09659571045764026,0.12674955320506845,0.4466838089248538,-0.1529773252341475,0.34616874614942805,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.056416649027180125,0.22605526160115053,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08526694110137753,0.06697574312359743,0.20410607549351373,-0.046609969754677294,0.21714385195743235,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0973125136128598,0.20739470635200777,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06300628660577352,0.086533118947328,0.4671893663650647,-0.10737958567120752,0.23339215888275455,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09701503237243624,0.18149811294594345,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15843622765510199,0.10436126495624842,0.13017730539561512,-0.04705370935182698,0.363926164662031,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10637399514389113,0.31411315508383003,0.7333906673033306,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11162694643696672,0.11484840670347068,0.3319683127452877,-0.11451243457510041,0.33776632744903384,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.013885661531849218,0.17660408224302582,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09257375133086956,0.10953943505415961,0.39881310729914676,-0.12311213191796269,0.30825963457970185,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.022841830196802054,0.1526970292419022,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08098499790108674,0.08472777577826515,0.3400379729732398,-0.08584610858954494,0.24781610439171842,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.028355920540545372,0.14140955855485104,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14093300913081702,0.07059757520482629,0.046933615537392906,0.0019246204555405932,0.27994139780609345,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04577665685093031,0.2324764585515657,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07257731579390424,0.09762565755342348,0.4578882460855255,-0.11965004202245856,0.26480467361026705,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,-0.02269241515112901,0.09170840470107056,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16279190273342067,0.19593309323466246,0.4068094300216417,-0.5485890565264756,0.22300525105963429,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.4413617186560483,0.1813994803301031,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12973329278183746,0.06342917946799324,0.04181788427511798,0.004839654335202892,0.254626931228472,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07134982570057626,0.23452141479726252,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12145341049126197,0.06157623308791605,0.04961061039220259,0.0002082697423019947,0.24269855124022194,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07083261518442774,0.2157873729814163,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06728901496446665,0.10359279519207049,0.5165478642373689,-0.13668778588510686,0.2712658158140402,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0590801162593292,0.14270651315710567,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12323129954488997,0.05367470235447445,0.022469028644238737,0.017544470142136157,0.2289181289476438,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09061789350960289,0.2315330897863707,0.3497238223097394,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06514050372649303,0.0928854612691833,0.48373634420621614,-0.11775328922500013,0.2480342966779862,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07403200803928418,0.1519870912301706,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09172295765282817,0.10165267622079635,0.3677140205099375,-0.10843370048996415,0.2918796157956205,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06489224076033531,0.16769984388361522,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15378791628428953,0.08084559118839409,0.05823183609462931,-0.005399071795585825,0.31297490436416486,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04065941933244761,0.2305697146106842,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09235427166683928,0.08162271394351943,0.25888477735621956,-0.06836289052566595,0.2530714338593445,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0631828562569767,0.1550069947180938,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1172261372740994,0.0770197375635864,0.1292036658867419,-0.034427649472033486,0.2688799240202323,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.12353199112237723,0.2570089399089921,0.731539728822366,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09562938172561448,0.10199044901588214,0.34929443693942774,-0.10519235948620669,0.29645112293743564,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.034851525911543335,0.1406805780317757,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09044640746879141,0.11437948377108038,0.429798135646852,-0.1347696525785635,0.31566246751614635,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08833959040263496,0.24955353644267667,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10155573837969659,0.10757459170809958,0.34601079911646226,-0.11026131925093693,0.3133727960103301,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08992736794984306,0.2216968003674091,0.9073781709238445,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05438678483785447,0.10720890100717112,0.6123713513984992,-0.15671021866992693,0.26548378834563585,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.05943426208829979,0.14951830813887682,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.102861000647709,0.11414654232865214,0.36834306360251234,-0.12189639188204779,0.32761839317746577,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0596474757539933,0.23433233795001485,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016409777147967507,0.06363499571656236,0.7967062268837647,-0.1088891186321346,0.14170867292806963,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10369553515137765,0.14161520008652462,0.9738068609884574,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026972463857610197,0.1259103432587964,0.8305418024135174,-0.22094814649162037,0.2748930742068408,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.03228714659063402,0.10313240068230234,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10914882862928199,0.1182986675572583,0.357032803377319,-0.12378420217037178,0.34208185942893576,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08158360334133821,0.24064544955772907,0.911668967477982,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11066442382204483,0.07165082680956038,0.12367058060987524,-0.030417843566756086,0.25174669121084575,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09034622178417297,0.18886481876578132,0.7255706347976272,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059831457315006865,0.05630753404897029,0.2889455741758562,-0.0510394834462918,0.17070239807630552,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11999762775182377,0.14434846213369648,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14079272203337728,0.09641490381511553,0.1454067537491596,-0.04905063143501112,0.33063607550176566,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09598537190417705,0.21083743422534892,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06470438164311312,0.06565998090045659,0.32531062485050843,-0.06458176053585968,0.19399052382208593,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.16633754578239407,0.17661631970623956,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16235920110678145,0.09878104938881034,0.10144814302437674,-0.03214315208810134,0.3568615543016642,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0915399311804066,0.2325817868612614,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07530809167779927,0.05891671551804815,0.2023013784683999,-0.04070039255755781,0.19131657591315634,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11218662279648478,0.16015328869830228,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12903205320307348,0.08790299489257827,0.14332861945627554,-0.044051139021253904,0.30211524542740087,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.08896016461017996,0.19934264335978036,0.7615412190387651,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12633244364936685,0.06005057323181409,0.036348364756860936,0.008091365258752425,0.24457352203998128,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.09327672226371585,0.20576044090197596,0.4572635807289415,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07545662266597322,0.07105609760391036,0.2892414797100051,-0.06445460806419351,0.21536785339613995,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07424952530485923,0.14600973765877348,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18463756680059584,0.06869728656227865,0.00765358625278457,0.04937089392011937,0.3199042396810723,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06170318843369821,0.24661629885579903,0.17308879679374334,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08304373939775402,0.044354416624611835,0.062277962992221395,-0.004291214638991431,0.17037869343449946,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.0660916885269797,0.13568137273814698,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09242898036046235,0.0564856347035912,0.10296720129844904,-0.018792645037653308,0.20365060575857802,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.06030691579254198,0.14201938388544957,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18150941654347935,0.13723831939003703,0.1871221662729452,-0.08871626171193758,0.4517350947988963,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11632405388053456,0.2491057648907382,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08770661537666391,0.05491613334531844,0.1114439641529429,-0.020424622650438484,0.1958378534037663,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.12821101539350993,0.1617545150197481,0.7040249164444842,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09622149223556573,0.06957883632680457,0.16786445073502537,-0.040780974147000326,0.23322395861813178,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.039173283163356394,0.13919907256129646,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10152256252079885,0.0559412690146049,0.0706928227686386,-0.008627193240767037,0.2116723182823647,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.11661467595870446,0.19089872102717176,0.6153066087033479,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05086983723283895,0.07936166538923671,0.5220889343072311,-0.10539526388907705,0.20713493835475494,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07183500748746291,0.11538465410778344,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1421102302708478,0.06788851316913344,0.03728139640214342,0.00843605239970227,0.27578440814199334,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.07070406454377048,0.19556763405133923,0.4631727895701855,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13013989577922497,0.06514942632355719,0.04679437391781399,0.0018590483127074175,0.2584207432457425,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.04143418345138064,0.17929138306161999,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05199493726373639,0.06664242719450364,0.4359702137056818,-0.0792256662037332,0.18321554073120597,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.10693169278229611,0.15343884609372313,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09262435648770984,0.06538993134394094,0.15781465337251835,-0.03613005137029229,0.22137876434571196,256,12,268,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,263,0.051025360228209575,0.13913717352233582,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03137420911525868,0.14812851919244185,0.8324435468020679,-0.3232036952850102,0.26045527705449284,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15195038216139573,0.12882105258510157,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12147400632931912,0.16483457321691244,0.46189092103455354,-0.4462162576334576,0.20326824497481935,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14125492393244932,0.02106401197733156,0.9370609591482926,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023736663590453642,0.06437612994781883,0.7126695936632585,-0.10309139778955714,0.15056472497046444,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06504444587944565,0.08788471910269434,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1562084448327886,0.13383285463430572,0.24431638585469231,-0.4198738984097613,0.10745700874418415,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2246722618009412,0.07810780740315142,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10662114376794754,0.09535219464243345,0.26463086784652473,-0.2944754618922546,0.08123317435635949,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20659750188985077,0.09558675560654743,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014012995801356556,0.11040430752671235,0.8991088017669885,-0.20349564137464823,0.23152163297736136,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0936422102385419,0.11426794197954883,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09796558548919297,0.10069159267414138,0.3315898811237199,-0.2963391054022168,0.10040793442383085,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20351830897636972,0.11551855442175991,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03649785539714028,0.07073373627204542,0.6063469774993065,-0.1758511009684427,0.10285539017416212,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1616527263823701,0.11428194287994471,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05273513870046125,0.06498730711240225,0.4179179300411764,-0.1807672863622457,0.07529700896132319,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12699229134832316,0.06936059238439658,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1803326453105067,0.14007032819583348,0.19920621363474034,-0.4562866083141701,0.09562131769315674,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2139783973826697,0.038325718765519365,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05015128834090971,0.09040335749471519,0.5795930764223061,-0.22825585260397588,0.12795327592215647,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14577217719434354,0.09796680617924833,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15777652581338922,0.13893058871051764,0.2572599426638107,-0.43148507658866875,0.11593202496189034,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2161251867922367,0.0626878924000146,0.8656758901506271,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12019144928990749,0.08980395336488206,0.1820673721031321,-0.29711512144542496,0.05673222286561,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1439989387607934,0.021020595094363707,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11664268854453702,0.06815017864862474,0.08829832203966304,-0.25090604124549154,0.017620664156417498,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15345465253277896,0.026400304010816326,0.659371665428829,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2057691617034207,0.26766596946343185,0.4428115270832711,-0.32156225806295863,0.7331005814698,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.01720671873169036,0.23362582264838197,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08302155447765376,0.14159420447650403,0.5582135718562764,-0.19593461252020883,0.3619777214755163,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.019278880800026484,0.10426007365314596,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07158213628924276,0.0689142031739265,0.3000053932089969,-0.20735070139531311,0.0641864288168276,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09686708531346869,0.013848462618654403,0.8872737746993358,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03467723107380129,0.07482920166310335,0.6434933784395136,-0.1820989942216935,0.11274453207409092,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16560952290567138,0.1347776064350295,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08841269243766096,0.07998266734048506,0.2701175113066139,-0.24598735017211093,0.06916196529678899,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12010823130439723,0.02753063337451597,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053876553110185535,0.056551691434184675,0.3417231418324562,-0.16528960944289564,0.05753650322252457,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10945279835971261,0.05662019679893044,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09972356780999417,0.12844318571834124,0.4382922964236734,-0.3527707804233372,0.15332364480334884,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12132066287611103,0.009711836594435133,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08693695297174131,0.10176259206241456,0.39380245917686163,-0.28742045955628404,0.11354655361280139,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15662718558023955,0.08594381664078551,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1253737691347949,0.07158514727246908,0.08118273405281165,-0.2664043880851568,0.01565684981556703,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.014291202192540937,-0.11666840171619028,0.6405850327149293,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16853869398467416,0.13514212476627072,0.2135943042428335,-0.4347835538228568,0.09770616585350853,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.2190569009546145,0.06016198118464481,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07770152461445919,0.08112421738192775,0.33914329921651043,-0.23752516157213677,0.08212211234321838,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12767705253740466,0.04733634779999156,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09636474482095364,0.06012382679997151,0.11032837207555905,-0.21481530098158047,0.02208581133967319,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17354723780545167,0.07560251281939404,0.7002905874282662,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022621794757779277,0.08624785153482971,0.7933290242904834,-0.19253955491546426,0.1472959653999057,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06136111773581447,0.03358408647564802,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08803399621442742,0.06761829227056589,0.1942164623996247,-0.2212494742099854,0.045181481781130545,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17255071108497386,0.08524477150392885,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07169389481438858,0.07937838162984974,0.367349037271121,-0.22807804318983166,0.08469025356105449,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11432013957821446,0.037074985412214545,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10416283230236664,0.056381333267920476,0.06593587398795736,-0.2152402642975303,0.006914599692796994,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16851039891420605,0.06605528565566623,0.5947207955047311,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1262818071750796,0.08944304393668792,0.15931144988431342,-0.3024944480345447,0.04993083368438553,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1647284987131878,0.02709822403235292,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12230003228200646,0.10428433711921928,0.24208125813054046,-0.3277516541774324,0.0831515896134195,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1663491718730802,0.04785675283939085,0.8491564414671808,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10031883213262037,0.11139576066012936,0.368742996109643,-0.3197807411030362,0.1191430768377955,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.18613640288362313,0.09571532051703555,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13319208480318603,0.06715070241563957,0.04847781434135377,-0.26548635932053966,-0.0008978102858323844,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07315753474725598,-0.0671956560714098,0.5221396068407954,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04990566282727503,0.15946164503346344,0.7545860156060213,-0.36406265425336226,0.2642513285988122,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14830772216066143,0.0943789287087818,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06736538640752837,0.08057037924927761,0.40394454840081206,-0.2260979012872047,0.09136712847214795,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15777897621644119,0.09323407823880421,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06996702863728915,0.15080401573181146,0.6431058936811282,-0.3670675374608135,0.2271334801862352,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1429499990080078,0.06236632327322359,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07308086886809516,0.08527447220592566,0.3923137956266385,-0.2410809646155035,0.09491922687931316,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15565961741694342,0.0807717750986814,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04805164605273605,0.06169029971907192,0.4368120268229334,-0.16958832627355147,0.07348503416807936,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10615142324537209,0.05346918965774434,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08839004466230123,0.06825259246615359,0.1965762325034332,-0.2228551638556845,0.04607507453108205,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15545569363956735,0.060168420509967784,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049237913260937995,0.06367531175772949,0.44014245558842346,-0.17468528567283398,0.076209459150958,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10742620306107396,0.05359895677972001,0.9319420678743413,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09835188497497659,0.0708223668844666,0.1662350462497331,-0.23787974260763484,0.04117597265768168,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13768831121306385,0.03304643024493246,0.7840604855201315,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0634223673856839,0.07085017007260594,0.3716165437268657,-0.2030050003590586,0.0761602655876908,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12360491325201353,0.0579477741482649,0.915561182973695,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0855636810631095,0.08419421723287498,0.3105481029357294,-0.25143555561829667,0.08030819349207764,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1814655813454227,0.08226330689645289,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09934906983335955,0.06128334914884333,0.10632793085799688,-0.2200840126409223,0.021385872974203204,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08792625574277611,-0.016353499036060596,0.6896374207352632,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09302981905017202,0.059578248734094535,0.11975786090656804,-0.2104055263734624,0.02434588827311837,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11897920992084537,0.016005821071782136,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09334734518872626,0.07311970327435863,0.20299040323355594,-0.23740120835952314,0.050706517982070626,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13625927763056997,0.03490465148458222,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056447902480428816,0.04482168001351325,0.2091395073541532,-0.1447515452827664,0.03185574032190877,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06934649900326746,0.007303150424258276,0.8226706686705988,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020194089084279502,0.07909036754713523,0.7986920896519258,-0.1760108180172921,0.1356226398487331,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08990072215320008,0.057942328821616096,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07414819933573069,0.06770796582451452,0.27458613168075074,-0.20754034410224212,0.05924394543078074,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14490569822616314,0.06926613698340958,0.8709804306040525,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06589523116420815,0.06375143474030555,0.30237289760946057,-0.191492574230047,0.05970211190163072,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,-0.03678814759270968,-0.11026761311260423,0.8904632102898862,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0945702830481833,0.04274400416271003,0.027895630307800595,-0.17878067575072415,-0.010359890345642442,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.23006881310428354,0.1320979029735977,0.3947157101306972,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10694145934083948,0.13728948273207248,0.43679362726804327,-0.3774168507147376,0.1635339320330586,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14178303181940932,0.0467018645199894,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15029619479560105,0.08165296666399503,0.06693063934381327,-0.31116152603429587,0.010569136443093763,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11085113797425726,-0.036834183795550354,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005745413301224099,0.08253262171337074,0.9445602154036923,-0.16834376180401806,0.15685293520156984,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17073280347418873,0.16074695902891456,0.9929703337140127,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.23396440544867952,0.1273594388920183,0.06746677870703265,-0.4848765175345337,0.016947706637174653,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.27479082635416974,0.040548288312947274,0.5990506592577463,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019790574472299004,0.10704467015588272,0.8534814726095172,-0.23068035625846384,0.19109920731386582,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14445787983372754,0.115249686484622,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1656407911864766,0.10920364292106573,0.13065957440888015,-0.38078398694148907,0.04950240456853586,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20302660065006398,0.053692652006273586,0.7355856040125466,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09642943744136166,0.08078940575513135,0.23384187378987334,-0.25559345864412364,0.06273458376140033,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16375563036901356,0.0620542007344243,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12668579311611775,0.10018675182707522,0.20730453200977905,-0.3240647209964931,0.07069313476425762,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14256029747919446,0.007098317623647646,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033636359827697145,0.054406467934633836,0.537014598913275,-0.14082308975813035,0.07355037010273605,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1278299513056976,0.08292958542574591,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09797870432014347,0.06484130254743618,0.13211820159822255,-0.22572320691935135,0.02976579827906442,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.03219967763028336,-0.06957187273190482,0.7380396089280018,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12644509027207115,0.08746852075058005,0.1496197575124892,-0.29876770313440554,0.04587752259026323,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1696790343759547,0.038828939715531564,0.7663649588223891,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05152132049428525,0.10083985150131874,0.6098851709311293,-0.2501869266145511,0.14714428562598064,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14167175095243506,0.09375830246895034,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06246653692910074,0.08837484998385865,0.4803685918403129,-0.23657471813364409,0.11164164427544263,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11339535381220016,0.05847089901474906,0.938972145291407,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07010745873752905,0.07723927499373612,0.3649845688754738,-0.2222773316049024,0.0820624141298443,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14151715373437435,0.0678332091002842,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04132662819623365,0.0750523928210353,0.5824055619895843,-0.18918810249017665,0.10653484609770936,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11861950816029326,0.07956805659293763,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030279692892597423,0.09577224872342915,0.7521590188961678,-0.2189615637885704,0.15840217800337558,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.20498051125334774,0.16730205508838397,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09880136294839542,0.07834254009451999,0.20850686664592377,-0.2531447894921712,0.05554206359538033,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1485874111571228,0.04564250539699226,0.82185729615414,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04058816899239636,0.08204357631520114,0.6212636590940357,-0.20222304423535098,0.12104670625055824,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16389394902379958,0.12478292664466284,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10583299890046012,0.08429887287502655,0.21056243816525072,-0.2719110565893231,0.06024505878840285,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14389551414206053,0.03234865640802013,0.8252886794984905,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12758349064164956,0.0830774748174616,0.12595304993380563,-0.29125525972727034,0.03608827844397122,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17158678172656847,0.035094136851123274,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06337973673505165,0.08399853233375094,0.4512841698842164,-0.2288660905014408,0.1021066170313375,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12160173587694535,0.048619315391715566,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1451562594523024,0.13419969223363004,0.28051954413481944,-0.4095444234749218,0.11923190457031704,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17701738408009932,0.03759597148906741,0.876035315676277,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025200691006157863,0.08475689416685218,0.766477928031775,-0.19218110105077907,0.14177971903846337,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13483388786969122,0.10412898964973157,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1466544319462632,0.11688679180864929,0.21084472688623565,-0.3769342766346001,0.08362541274207372,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19841102840898728,0.05033868600036998,0.8252886794984905,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.092295897139167,0.07556857244508934,0.22317628592863867,-0.24117430210439608,0.056582507826062084,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12498182117733667,0.0228175826570232,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11303221633925296,0.08997867835918216,0.21028682478474317,-0.29030011596417066,0.06423568328566472,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16119725841431473,0.04222561667210149,0.8251393055567431,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11123351009059794,0.07297109039827018,0.12876581027224276,-0.25499458953883053,0.032527569357634636,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11484902566035662,-0.006572794029947974,0.7302718857033121,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10988490298605076,0.07465514257426185,0.1423857972685634,-0.2569637505715873,0.03719394459948579,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07635412346583946,-0.03845879754379048,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09273517364813823,0.07792216550875192,0.23520795388773685,-0.24625041599057096,0.06078006869429449,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1459204961762589,0.04863239334925708,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09264499090675303,0.07001333911684304,0.1870390117956633,-0.23057897479376266,0.04528899298025661,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10131628798548276,-0.007583472676564471,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07127833712386399,0.09172463616627313,0.4378869449012992,-0.25198596579282534,0.10942929154509735,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1317805906411644,0.050979412802277135,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10046599536096353,0.0614208624617291,0.10324139446646587,-0.22147185452993823,0.020539863808011163,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09156168212442269,-0.019158728489458172,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08712863845289225,0.061601271252841185,0.1585689761075702,-0.2084899227965583,0.03423264589077381,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11436695771368774,0.02348802320096063,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07918466995496236,0.06574629979992802,0.22964764477985444,-0.20871211674762846,0.05034277683770376,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11036046758620885,0.023228440806779698,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07859114786379304,0.11465463664776535,0.49372940870869864,-0.30447340120913113,0.14729110548154503,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10032532960902227,0.013442604932012452,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07833311425238387,0.06837757986656516,0.2531274329242502,-0.2130444723809746,0.05637824387620685,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1395240185837142,0.07419109114486544,0.8627417615082431,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06943687899377209,0.09916739793745125,0.4844958565530709,-0.26480756751918816,0.12593380953164401,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16928797726891653,0.09406806743725123,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03725031685454691,0.07982656410856791,0.6411893302517044,-0.19451743404104446,0.12001680033195064,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08249817095398868,0.037317087034190295,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08246752102863707,0.12833782210916336,0.5211220510637067,-0.335307155735342,0.17037211367806782,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15502049485848582,0.06977049491592481,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1441442837450879,0.08965716491137775,0.10923756587589295,-0.3207787664913319,0.03249019900115613,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1543763024510209,-0.0019007940213066304,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044723539927653065,0.065753413930277,0.4970659543921294,-0.174265002340104,0.08481792248479786,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1273702129130456,0.08200781242585349,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1291013757921774,0.07182848802046457,0.073562906555156,-0.27061140279872486,0.01240865121437007,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.150559276314692,0.011986040194281964,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12621551009936682,0.09927047586009285,0.20483247613097738,-0.32178927347737674,0.06935825327864309,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16767975032957144,0.04512907664141703,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09557452887559854,0.032045389038497275,0.0031604714528745623,-0.15870747226960513,-0.03244158548159197,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.105086274692161,0.003806032273728089,0.09089790722071839,0.868683601359903 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05366060619459894,0.06563374656158397,0.41442721462344645,-0.1829663107198627,0.0756450983306648,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0900381150492104,0.03568777372758538,0.9266313996019341,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14783145703734038,0.11535485233417847,0.20126830382431068,-0.37509321235223825,0.07943029827755746,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17060405408255352,0.019652698168886373,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08083062590614049,0.07233373560077226,0.2649354581229559,-0.22333604625458822,0.06167479444230725,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13978195574917154,0.06091608068378919,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11690522664401262,0.047925260894639804,0.01545580429389783,-0.21132326536931736,-0.02248718791870788,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11260213319575489,-0.014883253955654763,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.088288358980816,0.07087000828772601,0.2140861758097867,-0.22791007542141614,0.05133335745978415,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1509144194971464,0.04711289893500551,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0709949095774015,0.040172881579735926,0.07848681196731927,-0.15013990780790296,0.008150088653099963,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06228141032578441,-0.01230781233363727,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04708833145124788,0.07351382826284954,0.5224475851240364,-0.1919186642276616,0.09774200132516583,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11102809034638107,0.052688760180824246,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054016422825395635,0.09969320109200654,0.5884513559713809,-0.25042300143637286,0.14239015578558162,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.026953415704355284,-0.022405212987118263,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009690162409673464,0.05707642081944617,0.8653329686231074,-0.12213699338425446,0.10275666856490753,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1259505193529081,0.10601642964680517,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08986573170869361,0.10616035118328544,0.3981298362050718,-0.29901330778869084,0.11928184437130365,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.04626422123587793,-0.04064045627579127,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02469357902129357,0.07604564042153715,0.7456814863821135,-0.17451186040730787,0.12512470236472073,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1171555054870571,0.07840230085964238,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04413835527800869,0.12057643099567715,0.7146487187152115,-0.2816871952548441,0.19341048469882674,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.029945107554049,-0.01080792604829591,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06885054829295927,0.044763782519929504,0.1253729272069064,-0.15704012666060746,0.019339030074688943,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08411421736156541,0.004776466170474154,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14127509145100928,0.06860553983714517,0.04057360867635207,-0.27643555581143375,-0.006114627090584773,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09874884508622807,-0.05689976511190705,0.4857817581793103,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07359839901874618,0.05681229146753472,0.19643056853088048,-0.18552486609938634,0.03832806806189398,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11282738775571449,0.031400978726476576,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11282825119644752,0.07278657216842879,0.12245727713543174,-0.2562258094233979,0.03056930703050284,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1601328658882102,0.0377934974159188,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02425066083316978,0.11463948064378314,0.832650452911012,-0.25010305518255876,0.20160173351621918,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17956329737041976,0.15871582304655804,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10369202576856666,0.07004024202626835,0.14008900071238864,-0.24167901134813935,0.03429495981100604,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17760055688363582,0.07780033246864702,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025584578937072045,0.04170381647270916,0.5401504115506144,-0.10774568740489585,0.05657652953075176,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10536597422195147,0.0767315888138658,0.9481163084809376,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10244143033345034,0.0750276421715163,0.17343841558100195,-0.2502541431237283,0.04537128245682763,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1315623945196611,0.022367225424613058,0.7876167865457628,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1441638462950254,0.07084110043649904,0.04297027248840221,-0.2837286110870448,-0.004599081503006031,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19608796362856176,0.0461974174181099,0.4970268279685195,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08118779625969803,0.07467295856418486,0.2780424574071925,-0.22830174330625114,0.06592615078685508,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15864681393682264,0.07159960770306466,0.8739920503526474,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11097987245685645,0.06430663102154649,0.08569927915955829,-0.23767101330290136,0.01571126838918846,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14072582899635827,0.025704350849359323,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11102060689850476,0.08562332716019601,0.19603495685025077,-0.2797079853015928,0.0576667715045833,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1684622395457607,0.04781221312669944,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011835217014959157,0.07101000493382277,0.8677732567251556,-0.15173274225671818,0.12806230822679987,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09611841797717438,0.08092627279907343,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17085886798641228,0.11234452631944838,0.1296425133044587,-0.392189949728986,0.050472213756161455,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.22415583254250887,0.05249214510912933,0.7324571321073261,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013016157488939355,0.06179013253642345,0.83334209813429,-0.1347495193477635,0.1087172043698848,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15300123851972078,0.14319661599043995,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17553746609124143,0.13550950075281482,0.1964572439951311,-0.44250609705714994,0.09143116487466707,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16356374030367143,-0.014770506060528241,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062869081750166,0.09833579238504664,0.5232305874946842,-0.25660141580895257,0.1308632523086206,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13527525687926445,0.07522971826581164,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10031119451484992,0.10368534716382045,0.33430984128593577,-0.30458274027194776,0.10396035124224791,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16115894200313632,0.06353193275500929,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1288274126192773,0.058291546077975924,0.02806595888439017,-0.24366817409260264,-0.013986651145951962,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16817149678386742,0.029373027979263562,0.3964191843848562,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020761735209961524,0.06797512341092674,0.7603079981979096,-0.1131567394057516,0.15468020982567465,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.010607893031681784,0.02536065433411552,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17271199479964938,0.1425286760905133,0.22681738235660795,-0.45350917372717464,0.10808518412787588,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.24139213431222745,0.046626520346446224,0.842579263271115,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14329641567597207,0.06897421033319576,0.038838396108870785,-0.2791832014903268,-0.007409629861617306,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12789145774333316,-0.015747539286238874,0.47377644413826986,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16657229191482073,0.12084464695881045,0.16939058418650074,-0.40464954685948573,0.07150496302984427,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.24194179474653524,0.0849407080205837,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023757827978042607,0.0806753492163649,0.7686458907327132,-0.18269714524611344,0.13518148929002824,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,-0.04104075644051979,-0.07089741380675756,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054528860901587727,0.06800518226578765,0.423459099233936,-0.18850655476972258,0.07944883296654712,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07971736592758076,0.01117498180274583,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0629407440530828,0.07351559970353219,0.3927842144917193,-0.20777456676261014,0.08189307865644453,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11623865381755404,0.05581676546229265,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07859748931310871,0.07814343514987887,0.31554124604353645,-0.23254865720199985,0.07535367857578244,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08599923098132731,-0.005318811201941276,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019557848228430548,0.06760401251751995,0.7726067907221894,-0.152745193538826,0.11362949708196493,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11840029984281868,0.10412353217600163,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08197238350403344,0.07234586330929271,0.2583426817212007,-0.22450169677306955,0.06055692976500268,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14400616721411472,0.0465942428338099,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11009002311765892,0.09952794395011971,0.2698048824652787,-0.30617102697054344,0.0859909807352256,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14820442327340194,0.030266835671433092,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04770586713479843,0.12197777069134573,0.6960754892882967,-0.2880155005467248,0.19260376627712794,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19004992641235016,0.14331815618314606,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10666998247147742,0.08911965063623357,0.23253989925872554,-0.2822455029356477,0.06890553799269285,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13296274966139277,0.022830707347349273,0.8436479526123232,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05661961041884255,0.06079849258735112,0.3526713473224521,-0.1763993324358533,0.0631601115981682,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.07421980617856964,0.012176864213982634,0.9092254482122848,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052975045686535605,0.13112893468666698,0.6865859717816373,-0.3113134793671006,0.20536338799402937,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16641522428187158,0.11914622645744587,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03758242632007783,0.06889514678252957,0.5859258419697827,-0.17331344823770659,0.09814859559755093,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.15941988015726458,0.113387123000429,0.952608653969109,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03308499155996169,0.08390165392873421,0.6936945685800617,-0.198380484205811,0.1322105010858876,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1347591824341989,0.10127421921220289,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05015616703140418,0.13975000093347198,0.7199927178580536,-0.32547905007227074,0.22516671600946236,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.18879927007834105,0.13650439000782505,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.129771903117769,0.10399394905900777,0.21331721203807946,-0.33465142857381003,0.07510762233827203,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.05465909091489869,-0.07660322012190966,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05860310320197066,0.10115277731542088,0.5629063708256171,-0.2578852076173423,0.14067900121340096,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12769682722213702,0.0755091618701061,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032583551659809494,0.08271222453148196,0.6939834652366854,-0.19553573748177588,0.13036863416215688,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1084332962517661,0.0761198838678445,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1572316511359244,0.07778241865230151,0.044369111546490834,-0.310471576790294,-0.003991725481554825,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16197538241599907,0.007564023062165383,0.5034452685637203,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06241863062931233,0.06871924207761626,0.36464303167581646,-0.19780310091779124,0.07296583965916659,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.022275442376225692,-0.04192306365482969,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03009653994163817,0.21459376831658783,0.8885834707112481,-0.39267680231868135,0.45286988220195773,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.38399782732256427,0.40610725378926954,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19208300915183868,0.07424291588168962,0.010277401659287337,-0.33834972478240355,-0.04581629352127378,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16333887687862106,-0.0249000727936639,0.20653674524410856,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16961615889406753,0.0736838946377227,0.022213706550468074,-0.3147815411468721,-0.02445077664126294,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16775968971562563,-0.0005744896360950451,0.34711102873546373,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05935825674760117,0.09626309570213486,0.5380788208448392,-0.13029063672015334,0.2490071502153557,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09747771114250016,0.15631533670329986,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16007437100210561,0.06720718728063153,0.018025081046257576,-0.29247992692034575,-0.02766881508386551,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.16008081912071234,-0.0021989057445247484,0.30508122248441927,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02896650504368572,0.07119317282546031,0.6844723658447137,-0.11129188110447266,0.1692248911918441,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10836635092924597,0.13106311634646692,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05809199485213264,0.0872757213400413,0.5063102531730651,-0.1138507819515002,0.2300347716557655,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.10998938556141401,0.16504202839046916,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05781204658169038,0.10593036208446355,0.5857518935714559,-0.2665065188238869,0.15088242566050614,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09816801242830868,0.03283735049124498,0.952608653969109,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016022906020529453,0.13888446846151312,0.9082514885582051,-0.289640594829171,0.25759478278811204,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13101432954657127,0.10202993556015956,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.103243665145808,0.1096177411578866,0.34723572491726507,-0.3192026800039483,0.11271534971233231,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19052297679146923,0.07730339116045555,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025697732013867894,0.09513959447662179,0.7873161065423804,-0.16173774038453392,0.21313320441226974,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0706254558939565,0.09861239602563643,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14430607948732727,0.12436134088472232,0.24707268151078415,-0.3893116085213447,0.10069944954669022,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.21494035546556337,0.07575684541800462,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09474339263071609,0.1006406479217562,0.3474651659066027,-0.2930165457744462,0.103529760513014,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.14442074081435616,0.049207692564189255,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03323439111974631,0.10668660161134888,0.7556859300506575,-0.24341873846334372,0.17694995622385107,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17421874029426598,0.14748265438176061,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16976877683057445,0.10272623224142749,0.0997409171822002,-0.3721507606281954,0.032613206967046476,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17746124464301444,0.008032175673492363,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07944446153916504,0.09491621950164775,0.40344537277367887,-0.2664398606517119,0.10755093757338177,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17977256557639568,0.09895856818110126,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07310103085190824,0.14318485134340023,0.6101551829417384,-0.3551909472477566,0.20898888554394018,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.060967775959663795,-0.008041609933852984,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08790936947908908,0.11493148722650094,0.4451074529993059,-0.3143370489353386,0.13851830997716047,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.19626246579427062,0.1018453399441879,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10379421876444847,0.06851050161908669,0.13111327571786738,-0.23876744737517602,0.031179009846279082,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12671960828354872,0.011573609935505127,0.7360778123788349,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0566646551003992,0.06291551958595032,0.3686982451813381,-0.18061515330944128,0.0672858431086429,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1252776053640268,0.052130207465816085,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06796416107167916,0.10663438719661832,0.5245128591073986,-0.2780456402714205,0.14211731812806216,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1346559091263856,0.04859143269736208,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030893278590316386,0.10784475486392514,0.7747777120655045,-0.2433593153104616,0.18157275812982884,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13712114514296891,0.0904493517087269,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0465379512491401,0.12757387420910188,0.7155946112911571,-0.2978725245108861,0.20479662201260587,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13321938405453354,0.06865031329159285,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0997262999017794,0.06276184967504796,0.11341303663222567,-0.22337405147308506,0.02392145166952625,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12656250417438333,0.009878616438975169,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055756527503185285,0.09614011125431267,0.5625034622738931,-0.24516312807278295,0.13365007306641236,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.13207208038581267,0.06149989341804734,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1072292985632748,0.08854069999537226,0.2270837215520476,-0.2816642225443282,0.06720562541777862,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.11988146347411445,-0.004952687612057837,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016721735847682367,0.07609057042902004,0.8262481092666596,-0.16662853429353644,0.13318506259817173,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09927906512918455,0.07576313382623523,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08454981664487647,0.08642601249959067,0.32893628683624276,-0.2548185735119402,0.08571894022218728,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12968323000254697,0.034779948701281496,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017023427776583902,0.05895571219610723,0.7730276825384994,-0.1331726696022566,0.09912581404908878,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.08474681896192711,0.05961912119555043,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06049790554228493,0.026780649242245987,0.024799661738970136,-0.11325873208847892,-0.00773707899609094,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09461247333111483,0.02529514920853576,0.37213556688836474,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19865760235749683,0.14425083212592185,0.16977072640202856,-0.48284761821917443,0.08553241350418075,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.1779387160130496,-0.041104564157601,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07449398923836834,0.0785654962697223,0.3440134173462739,-0.22927666398635474,0.08028868550961807,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09796391692908717,0.0016756024163885647,0.9053547642872083,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008565568249298902,0.09480149020479281,0.9280839248447386,-0.19533493801967497,0.17820380152107715,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.076503639684012,0.060529767848013824,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10322921256459265,0.08827968013439909,0.24345021211805123,-0.2771498986910913,0.07069147356190598,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.12875226512466884,0.005849814226817652,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032789497228597905,0.09901239303892242,0.7408145227485747,-0.16227581458652585,0.22785480904372168,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.093504017388159,0.12313099359006215,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11952148406907044,0.07241166499926839,0.10015949099875245,-0.2621804339096418,0.02313746577150093,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.09550030492219293,-0.037109443079623064,0.6801249269017082,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0640714226643548,0.07741427720914618,0.40871210074427644,-0.21658606915722656,0.08844322382851695,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.0828437660776911,0.009384467938706589,0.9253726913029282,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05673934786550759,0.0608426839483564,0.35200520995682816,-0.17660613172750012,0.06312743599648493,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.17090922645965198,0.10845867633361299,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06367674469620818,0.06369316570737353,0.3184635924589602,-0.1891592913539491,0.061805801961532736,232,7,239,2,log_other_mut_burden|lin_Lung,False,235,0.06562643232559434,-0.006829587126921158,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04606889987409761,0.121117973162163,0.7039100893561896,-0.19215610804757405,0.2842939077957693,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13166633385462662,0.2117905979208715,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04043570435198411,0.09217076371918072,0.6611512555190303,-0.22172490812482099,0.14085349942085273,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08652435644527759,0.07417689152449623,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033326931980576464,0.07810952684877488,0.6698871526346457,-0.18695931342237895,0.12030544946122604,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.050544374074549016,0.05061854138921305,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01060183651861641,0.1203361238686876,0.9298469817504651,-0.24728903754615889,0.22608536450892608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1634648189157226,0.18954564468216775,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031158828777966698,0.0608816021185784,0.6091236840232038,-0.15090588008936753,0.08858822253343415,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1560416637904303,0.10600362028739313,0.9546345120979649,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09526110997938857,0.09118520797953227,0.2968955862454121,-0.27461183990102705,0.08408961994224991,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0798624668973259,0.029510155749829695,0.8843360296870468,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05982402065043024,0.08743174054678945,0.49428629145812275,-0.2317921153978349,0.11214407409697441,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13663114642382954,0.08022019761193998,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05949174279297782,0.06638991906171296,0.37082810788100606,-0.1900730147667109,0.07108952918075527,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1327213491115249,0.06835276249586751,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019009155370747818,0.05379589352532121,0.9718325518597084,-0.10771119973052423,0.10390936865637468,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0927678864314953,0.0893070939773538,0.9975956028271519,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030113735114483592,0.10395698315608776,0.7722394295673103,-0.23458506574610183,0.17435759551713464,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14497113468854253,0.1285751388411305,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019393705627654544,0.07584714488653702,0.798339484026271,-0.16857624410391828,0.12978883284860918,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12974942172526016,0.14888355831373465,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039715675518504245,0.10466913268710594,0.7045951318851236,-0.2455877216941407,0.1661563706571322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14916650369194542,0.12309111936519342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016720380734098577,0.08679899514382164,0.8473598016262667,-0.18744393864936362,0.1540031771811665,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11358869074228016,0.1198673407376546,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04604761983560219,0.06349787829380238,0.4688324087271434,-0.17094058299060313,0.07884534331939874,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10926612320444207,0.05617954911702521,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0958613497970348,0.14481024022647002,0.508427830816109,-0.3806862995912485,0.18896359999717888,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-6.984673028851706e-06,-0.055979985846765945,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21689923139384196,0.11639954746692227,0.06325755944037145,-0.4458436431390769,0.012045180351392959,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.005682556490099073,-0.1671098382844003,0.5832038406941563,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05496360845285847,0.05777419246596341,0.3420935241931885,-0.16859874532428631,0.058671528418569374,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05900177224892376,-0.0038059592785672732,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008394837487255898,0.05994654075148998,0.8887113459164837,-0.10951305654825788,0.12630273152276966,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1415442217725226,0.18440944820189129,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018460264181676758,0.07064593796444557,0.7940122947564097,-0.15741263179338572,0.1204921034300322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09241948376184292,0.08377316796509138,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006610074786579314,0.050786851297751234,0.8965212383565309,-0.09328177228491014,0.10650192185806875,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09570499347308707,0.1375006488576393,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02567404779660273,0.11647638913844818,0.8256726750107136,-0.25476959819888456,0.2034215026056791,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06866332527658761,0.061981271601488454,0.980597249022118,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05327963834784658,0.10050078459870057,0.5963558341037256,-0.2509530272106568,0.14439375051496367,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12084955812434721,0.10962054355161617,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07691840687899754,0.07174911693747765,0.2844505516945563,-0.21804059960194513,0.06420378584395006,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.0030686011882354726,-0.05358522381123115,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11782038944549222,0.10954360976706184,0.28287922521515685,-0.33327996677500427,0.09763918788401979,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15862084865167336,0.06169918796792515,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0005646026142393148,0.05330066098507858,0.9915544762902182,-0.10540082183002925,0.10427161660155063,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09280628653706252,0.10265513294360318,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04042576011182438,0.061610043418925384,0.5121628095530608,-0.16160557098825934,0.08075405076461056,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1503076625587817,0.12091459561190881,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008374735105987968,0.0630571448568399,0.894419848049756,-0.11565135648758784,0.13240082669956377,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.03189501114213744,0.06718461608646568,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04319597775870326,0.056757042140849624,0.4471377381476398,-0.15483049789314746,0.06843854237574092,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.168452749304407,0.1376217442238509,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014815545295229288,0.06413156632429404,0.8174381682423075,-0.1113238087309401,0.14095489932139868,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07655942340492147,0.10996805319785773,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033364175811287644,0.06344984618779104,0.5993413759064636,-0.15816266538374502,0.09143431376116971,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1412556544927532,0.10757764854865141,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014765662504391524,0.07817172091590965,0.8502923634199336,-0.16852037246399396,0.13898904745521093,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11744569261551623,0.09894547701991518,0.9831931217519931,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0530590289537792,0.08338609298941646,0.5250004660196698,-0.21706980410409077,0.11095174619653236,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09459865642088977,0.050436672450989935,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0849429806793682,0.09886060249010263,0.3908176368163906,-0.2793903215361523,0.10950436017741588,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12708024767160778,0.0578565932770779,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00432500481199774,0.07354522475598052,0.9531396458440292,-0.14897993333063228,0.1403299237066368,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05662411604905898,0.0699194556772778,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06126896332152366,0.11659635755171975,0.59958863380364,-0.16806255103768228,0.2906004776807296,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08749413882953955,0.1657276890353169,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024593817854432133,0.056593694268299216,0.6641483734775901,-0.08671941595712909,0.13590705166599334,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1655119579396263,0.17902248493325676,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02526225660893527,0.07805246368287949,0.7463941114282362,-0.12825788820280684,0.1787824014206774,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10474833014763985,0.1313146690359003,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10397284438415322,0.07756999362847948,0.18100817012862097,-0.04859833777959671,0.25654402654790315,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1976717985701108,0.27483492030805623,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008894060028320732,0.04845182775742184,0.854462867787795,-0.10419318657395156,0.0864050665173101,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07375337805820746,0.07494234652912879,0.9834313824125731,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03434284056101568,0.048724664454868026,0.4813899584191109,-0.1301786052513702,0.06149292412933886,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11672772259359078,0.06730846662416591,0.9396519533333579,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01688900382038637,0.05967251004207884,0.7773254479829854,-0.13425791122810338,0.10047990358733065,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0720787363044123,0.06490956371497254,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03838399256913371,0.05401953332378006,0.4778398418132851,-0.14463415031205323,0.06786616517378583,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09651630179761161,0.050785057023308766,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00965633381437015,0.058550064671520075,0.8691003642740872,-0.12481752134111629,0.105504853712376,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0870554886008042,0.07013474439276758,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027644187261712406,0.06443222631125937,0.6681605901641777,-0.15437490461659809,0.09908653009317327,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13560042227480912,0.09210264520392465,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02100925562245473,0.05423874891021716,0.6987383421240132,-0.12769058500284552,0.08567207375793608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07102697659402897,0.047376787984379505,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04499022784884291,0.06502418661164285,0.48946692177009055,-0.1728852624686762,0.08290480677099038,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08707302949409704,0.040498243983099556,0.9415307631280134,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01455583096388334,0.07373041199625117,0.843615764028025,-0.15957500130913266,0.130463339381366,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09415644159478305,0.07394887448991709,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03891320103385302,0.05199763267645974,0.45475145077725887,-0.14118651467057355,0.0633601126028675,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.04911060627253675,0.006096712920715952,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01232929165700728,0.049817986141875305,0.8046791890793279,-0.08565691000606249,0.11031549332007703,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07224864915114863,0.05633159759889097,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035669159698279614,0.059066883120793195,0.5463231216695624,-0.15184686918256637,0.08050854978600716,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10580700712797732,0.07642015326868073,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06444942443562518,0.051599018408143155,0.21249839283344812,-0.1659387100313524,0.03703986116010205,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.06791813783878956,-0.12033767285406587,0.8284932427858109,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11187881572535006,0.05293150642009335,0.03526441727290458,-0.21598895072034327,-0.007768680730356858,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.22364543666236086,0.1007098106841332,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06807088253684547,0.13328023879432507,0.6098642276013377,-0.330217656575657,0.19407589150196608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07748014025251145,0.054223029965090215,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06128397785346996,0.05978096296210555,0.3060165013054003,-0.056298243871337715,0.17886619957827762,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12916749386890666,0.22811122037953122,0.8944539216937829,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007178118442607063,0.07574163724507,0.9245518193071359,-0.1561531356231617,0.14179689873794754,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13302459012615875,0.12742157583744443,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06568943091848704,0.08367328374389356,0.432952541738708,-0.2302650769791526,0.0988862151421785,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.18932965837292742,0.09987251364284873,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07489202361138689,0.08719590903675095,0.3909972106613748,-0.24639626512644028,0.0966122179036665,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09256100313201708,0.023501716750379906,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06424548484858486,0.09589309285521869,0.5033264566378834,-0.12436510867977951,0.25285607837694923,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.17230651759715326,0.27230503146242296,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045169506945882384,0.08062210284803911,0.5756653628425613,-0.20374383401062823,0.11340482011886348,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10785931698143393,0.06276351553437386,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040089315817471445,0.07132695724616038,0.5744479866153813,-0.10020253774785487,0.18038116938279775,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0998522022714378,0.14704333466551803,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10184406180102133,0.05008760154285889,0.04278758303339417,-0.20036056569222632,-0.0033275579098163283,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10721592510925763,-0.005791165187667456,0.49583625418844224,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061190464192900834,0.05535505319160683,0.2697510829179135,-0.17006743464401033,0.047686506258208666,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0024192617295030086,-0.044113401705591714,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08410892872775003,0.07608152730697174,0.2697110084868898,-0.23375247024515616,0.06553461278965611,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10848881982574918,0.013693775890223197,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014723616058372423,0.07657592170306939,0.8476404513139653,-0.1358923419043544,0.16533957402109922,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1013763772328346,0.13734240706981302,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09112118195104908,0.07835517227598963,0.2456660440295102,-0.24523671946223036,0.0629943555601322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07994251796204904,-0.007415555015675074,0.8545561163480508,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0510307135833733,0.05964068067913966,0.3927947153254462,-0.16833701632523967,0.06627558915849306,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11009385959508809,0.06842309445132934,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07331404152257825,0.07728607776225668,0.3434869298184061,-0.22532679410140227,0.07869871105624576,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07606314880617362,-0.004436837280900048,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057048214509592306,0.08260888551072565,0.4902939095962072,-0.21953031267717393,0.10543388365798934,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.18838580907968877,0.14141471485843515,0.9418332435783486,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07544170359442559,0.05905801885567489,0.2023166002049426,-0.19160197809715762,0.04071857090830645,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11273326174228938,0.036753940442228475,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08309393998840531,0.0636176306484823,0.19237545463478012,-0.20822244213813554,0.04203456216132492,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12716262990934815,0.04612696462882468,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007331601655038524,0.05465619003943277,0.8933700197851389,-0.11483398932857856,0.1001707860185015,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12359971489655572,0.10009322466400354,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027958300930224528,0.05511709909124665,0.6123025011682519,-0.13636724325996347,0.08045064139951441,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1428453088020242,0.09575230954470704,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042425636724492594,0.060808480978120874,0.48584065102508167,-0.1620288672320115,0.07717759378302629,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09627328048846368,0.048293505925931325,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041991950267701444,0.12637796698958415,0.7398857127523091,-0.2905627560795644,0.2065788555441615,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11979295467510176,0.13679104443063342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08275428755081246,0.0651701645401472,0.20500754612447245,-0.21093644382787308,0.045427868726248155,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10526810194229755,0.021219039530191677,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016267350773100098,0.09059380170089949,0.8576008895441535,-0.19445485312632818,0.16192015158012799,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13994790878589475,0.1261370200125736,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034308254881885686,0.07912764451620986,0.6648643957827265,-0.18994315571084106,0.12132664594706968,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08823283416893093,0.03794193160821893,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007468333923775199,0.0617216879234965,0.9037615557933891,-0.1288677365939917,0.1139310687464413,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12531300259831263,0.10551567288172621,0.9884347244265531,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047740351312947064,0.05980179879629863,0.42524160316285475,-0.1653635547074121,0.06988285208151798,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08014932452610089,0.03087280688762283,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003123368324004767,0.05775943014302117,0.9569064262208418,-0.11048273277008928,0.11672946941809882,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.058588882842943474,0.06398007272505958,0.995747388821315,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013927004262367117,0.07862098650874552,0.8595018486563246,-0.14071135901984305,0.1685653675445773,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1163898024643759,0.14577426757206965,0.9839789607467108,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07651004986342358,0.055657500650953255,0.1701321533723783,-0.18598189939414106,0.0329617996672939,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05785221184616868,-0.061961151249396655,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027065263534082045,0.05132827395573822,0.5983270004043082,-0.1280220261884572,0.07389149912029312,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09556479079354421,0.06224852869858403,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009405378921465188,0.05000606693192693,0.8509211097750236,-0.10776151368802218,0.08895075584509181,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06333195212675503,0.031235560934471603,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028786090266016973,0.06630581990554082,0.6644580507853733,-0.1592019489520088,0.10162976841997484,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08379320755053672,0.072465882532681,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017013877679334582,0.04736345964490462,0.7196512909290596,-0.07614455500016815,0.11017231035883732,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10539016222853294,0.1339244295494195,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013995893683431092,0.0870430847570529,0.8723510492656181,-0.15720776019552515,0.18519954756238735,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.047004646684249245,0.04144128559670435,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025617559214503146,0.06489387432169226,0.6932640535082135,-0.10202116624249263,0.15325628467149893,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11418571437053252,0.1812110488627593,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023976261789214106,0.06405711019535779,0.9701642554740019,-0.12359528127583856,0.1283905336336814,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13147433777383122,0.14186535859035368,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08492722838184923,0.07153838300428672,0.23598518120784184,-0.2256349318956969,0.05578047513199842,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05590824789669556,-0.024072788886954733,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00405634499201013,0.08910398666804978,0.9637162831557748,-0.17120086395606607,0.17931355394008633,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09950064676826982,0.12154023449229505,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028437562850215183,0.06692313812688527,0.6711543088265611,-0.1600676148910865,0.10319248919065616,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10482048640881385,0.05487084117829107,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02751015423409673,0.072264255936964,0.7036695513641504,-0.1696455656316096,0.11462525716341615,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09869673842182662,0.10321381499046184,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03635521244256363,0.056211296873977835,0.5182186463658318,-0.1469163149237114,0.07420589003858413,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1212418000407559,0.06938989093466207,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009250962598993905,0.09063212345359224,0.9187593427411184,-0.16901191419784858,0.1875138393958364,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1304790328761559,0.16745827880689912,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013324158616405835,0.08673802076499555,0.8780043136063924,-0.15727946976652285,0.18392778699933454,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1406559755017926,0.19246771438781987,0.986092730312823,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06115509172075864,0.06782920476320475,0.3678980030519593,-0.1945672717644308,0.07225708832291353,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08405785635941847,0.06167228177271614,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002230867041828632,0.07372662936270621,0.9758783346343739,-0.14278086330188597,0.1472425973855432,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12822460351646456,0.1286289421010819,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0185943159872811,0.0756293692944868,0.8059364229832822,-0.13015988315348329,0.16734851512804547,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1066165165476937,0.14444175112057597,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014914376342176894,0.07205558975996436,0.8361445787887921,-0.1268106128828796,0.1566393655672334,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1141001875507588,0.14963332452076897,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008978780416011177,0.08115976725004147,0.9119735360204977,-0.16861063100994228,0.1506530701779199,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12096025149804301,0.08101428567063529,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022020969145548613,0.05233270809963656,0.6741727406751432,-0.08091139899197487,0.1249533372830721,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.04009276585281254,0.0627090182010158,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05611068183328866,0.042208401981916166,0.18460608438090467,-0.13912971388925335,0.026908350222676035,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08513992056122008,0.0037312143737481076,0.8047111541643488,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10356405671510743,0.11114180602372549,0.3520835336770324,-0.32216710074872557,0.11503898731851073,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.007971484087280548,-0.05030045418278867,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04689915565424451,0.04837583235036038,0.33298942567116174,-0.14204880804689404,0.048250496738405015,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10022811456930622,0.03826123044126545,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0876120664408823,0.09376130255298928,0.3507447565363703,-0.2720296756550525,0.09680554277328789,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.040342169949271464,0.01324014121590822,0.9088510667694087,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0776973850787649,0.050193657883630054,0.12255325418926594,-0.17642248949358108,0.021027719336051284,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09494121513113998,-0.017719739555766844,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07105372697984906,0.11248571211227779,0.5280227801486674,-0.2923000784453271,0.15019262448562903,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.019329557007907817,0.0018711778986211282,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032796858492329356,0.04431802671773476,0.4597839501364308,-0.11996527776375926,0.05437156077910055,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05006955865286005,-0.00752204598380013,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07272184520454505,0.0486721066917562,0.13606159602914916,-0.16845423486965133,0.023010544460561208,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06212569735262675,-0.04200642719685863,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009138176967264024,0.04531216491393125,0.8402926658454546,-0.09826195078666891,0.07998559685214085,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09313260869338942,0.07453662437155602,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0733307178949377,0.06447727630180326,0.25619984187060985,-0.2001500433570596,0.05348860756718421,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11815974621369346,0.032973694583778745,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054652015752781336,0.07916448720604691,0.4904331744440391,-0.21035938188023154,0.10105535037466887,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14060207052166265,0.09609979970601602,0.9418332435783486,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02361566564622427,0.0813437480329456,0.7717468542064507,-0.1363780538125869,0.18360938510503547,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14157589415023955,0.17292927036653039,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06726214044870193,0.040513249052771254,0.09777528510359929,-0.14694700326924431,0.01242272237184043,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0886156942392338,0.023132714930248686,0.6772213442508546,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015031968344447883,0.052342980543842024,0.7741457823216129,-0.11798454118849287,0.08792060449959711,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10552717598759248,0.10090459235212516,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10521771731315506,0.048423488622082976,0.030472541400301787,-0.20046110406588533,-0.009974330560424793,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15209395977641746,0.028729076737496237,0.4177738059336711,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004966004244117323,0.0681464905602748,0.9419499398870541,-0.12907024016875662,0.1390022486569913,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11904053002527816,0.13081575252073266,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06874229809480709,0.059274912882658494,0.2469671500570579,-0.185329177996782,0.04784458180716783,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09590939872138204,0.02455215295489874,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008529776666846369,0.08031223337647556,0.915479477925109,-0.16649462641463716,0.14943507308094442,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11888896335156215,0.10368106388955511,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06157811628239839,0.07669581658170717,0.42259410050892887,-0.21242989356795197,0.08927366100315517,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07148204862122154,0.02912052463835887,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02919466932481866,0.08818056239253386,0.7407869347501481,-0.20263560980665069,0.14424627115701338,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.16421303771785936,0.13968109966146758,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033479305231018275,0.0638731332533152,0.6005095629191128,-0.1591103513754274,0.09215174091339084,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1387099256405781,0.12221939036412223,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09871220675770484,0.09980573078775666,0.32333702431467726,-0.29501850537540003,0.09759409185999035,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10465288149949746,0.015595299965522641,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02445133363704164,0.08158561342374529,0.7645858325568997,-0.1849207742719502,0.13601810699786693,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1099615152483248,0.10408901421272264,0.968605544021173,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030099253599340754,0.0621184603221213,0.6283067722549349,-0.15227906156645685,0.09208055436777533,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13938527433893627,0.13414282513905385,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025258224132818675,0.05834435624426258,0.6653468596983647,-0.14001480703785968,0.08949835877222231,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13335214297401646,0.10456218849769655,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09032424623260825,0.08188899614440397,0.2707945725178423,-0.25139040549766967,0.07074191303245315,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.009986592713289512,-0.0322966273942242,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10566025884787962,0.07012829656583508,0.1328127743643363,-0.24359448585613358,0.03227396816037435,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15814252505183574,-0.037906408721947046,0.7413978923376241,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05537090078698474,0.060978379284459545,0.3644919623340951,-0.17530830156103555,0.06456649998706608,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08720176165150492,0.0374322276774652,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041233655698428046,0.09721385025004654,0.6717185341677074,-0.2324420258625045,0.14997471446564842,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.18731137147015295,0.17879226771205403,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06959795194899686,0.0611145899591479,0.25557452613839254,-0.18980326332466585,0.05060735942667215,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.0514172636521923,-0.11664610485073097,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03636867261426243,0.0605559631819969,0.5485155372311541,-0.15547522989970342,0.08273788467117854,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06971624701153334,0.011803599701038598,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020077121873035394,0.049893386501115446,0.6876392573415153,-0.11821162729902587,0.07805738355295508,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0969216281695931,0.09707306489007739,0.9632925656593531,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02524329335178259,0.06886637884592814,0.7141765707406165,-0.16069547454162747,0.1102088878380623,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.05750151726513253,0.01643589110681402,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014078788428670493,0.04840223769289106,0.77132556747461,-0.10928037706801665,0.08112280021067565,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10898594542768973,0.11845335636498659,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04756450370885902,0.05650529931483059,0.4005011317357122,-0.1587038748975533,0.06357486747983526,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11414784004867295,0.04727526375954636,0.9219399112464703,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052677816077024486,0.05278439585433872,0.3189901180950088,-0.15649860164866386,0.05114296949461487,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11456391197051141,0.04543179820864687,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0045518714215478165,0.0915111307034651,0.9603575098131847,-0.1845436535459572,0.17543991070286158,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13960977174020237,0.1696612011205307,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004668622469048117,0.06864796908344782,0.9458186453982234,-0.1396912169836984,0.13035397204560217,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09001074123178927,0.09280400732452009,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04761211609755296,0.042272245362272066,0.26081480175741206,-0.1307567206791631,0.035532488484057184,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06362056074867231,0.015987356767783723,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03502867095612203,0.10177137957736995,0.730913853678985,-0.23520117279908004,0.16514383088683598,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10855113983360086,0.10659704525987819,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02720344254785247,0.07889725123665964,0.7304585819139788,-0.1823851865131897,0.12797830141748473,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1208029385930482,0.09603216166827981,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07231638375981014,0.08929685152407733,0.418590546554537,-0.24795293551437025,0.10332016799474997,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09921729356158393,0.06114199953833691,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006179649622310284,0.0643297406133249,0.9235271933087024,-0.120349490249359,0.13270878949397957,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15986944171872855,0.161380473572794,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08642298464944315,0.09027720068212809,0.3390846814272589,-0.2639877695129734,0.09114180021408716,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.0038990680909883457,-0.05458266532732544,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08985280185479448,0.09518670145874061,0.3458506426686241,-0.27707400542204647,0.09736840171245749,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07489030648951082,-0.008803653780470365,0.9073781709238445,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05261563318035842,0.0712892551439437,0.46098215137583376,-0.1928333310826998,0.08760206472198295,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08976882321554067,0.07516770914415556,0.9369772953428787,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010548945264779307,0.08554727935439946,0.9019326158803473,-0.1788105233758452,0.15771263284628656,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11114222447263608,0.11504465024243349,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034384806098170954,0.0752487996315553,0.6479966664553325,-0.1823904688442153,0.11362085664787339,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,-0.00870350033531084,-0.017512057396649395,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.157869520447595,0.09426540784770997,0.09489515623365875,-0.34327864631856564,0.027539605423375607,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.4027050635923872,0.17161029429903418,0.6729775750805861,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0070260635161012025,0.061124326487789794,0.9085541235461401,-0.12725052551452493,0.11319839848232252,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13234571549499194,0.11930501170750751,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007468055510707009,0.05696848316436616,0.8957799501545571,-0.1195184556189248,0.10458234459751078,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13433905358109544,0.11150017930448804,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08412104499345102,0.08170773916979476,0.30395127610561834,-0.24483069280868552,0.07658860282178348,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.054407826414197884,-0.015758321978841573,0.8913059585247131,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05030159395118709,0.053722345617576696,0.34976255523902156,-0.1559672179389906,0.05536403003661641,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1252547420307224,0.06507237463476756,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08848017509023158,0.07788761500418799,0.2567481957506104,-0.24167608166745025,0.06471573148698707,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.053562977571919586,-0.032441186165094504,0.8647791852375212,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06303946683721953,0.08664561914534369,0.4673808209218908,-0.23346135194952672,0.10738241827508765,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06280868848521126,0.012506126640140535,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04114242539917914,0.057869123187232314,0.47759299527651755,-0.15496427999082524,0.07267942919246698,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0866870824581372,0.05552168459912016,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028908753656806063,0.061595897674562576,0.6391316697940326,-0.15006074149447224,0.0922432341808601,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09476816541221864,0.039666416694847335,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035372114568025664,0.07777836532178117,0.6495537354092826,-0.18835313968894749,0.11760891055289616,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14753261356503633,0.10847588666301285,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08129703757442705,0.07505121351719382,0.2794690779865955,-0.22891407134633926,0.06631999619748516,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.04594405816148327,-0.01437728254285741,0.875118556630215,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03801090626957865,0.1122528197977661,0.735103565136471,-0.25879918555946674,0.18277737302030944,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.15075775033675376,0.1357527861835832,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10985723541096735,0.08839952432646121,0.21481170162578533,-0.2837288486251985,0.06401437780326376,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09578953587176359,0.0014254896586881223,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03873340899590523,0.0861849125340397,0.6534101793127072,-0.20824913762902075,0.13078231963721026,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1076301378281214,0.07142416191907812,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0345821362477931,0.09632445430224194,0.7198024741162812,-0.2240411677201828,0.15487689522459658,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.13865977380607178,0.13434093075668047,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006964036191198874,0.049356841127900564,0.8878769574990013,-0.09011514670546462,0.10404321908786236,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.14897487910393836,0.16036106445716972,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13335053471467034,0.09591459386882983,0.16533515849698177,-0.3220034182434708,0.05530234881413007,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.03130144271242471,-0.030298128404972546,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03836134421495885,0.10869652086156939,0.7243634090232256,-0.2521547958989309,0.17543210746901322,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.12227894323805782,0.07481666625059476,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05332783761104411,0.049492480047604995,0.2820147554152556,-0.15067380653357523,0.04401813131148702,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09124781274035816,0.013459583485390158,0.8770089248428307,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055712858379055104,0.058052202951079684,0.33787888379693465,-0.16989480963558218,0.05846909287747198,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11244916600632081,0.03511239253554924,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12010473376414046,0.0432093057368055,0.0057417045871045675,-0.20509242743746975,-0.035117040090811194,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08686311092934619,-0.08744605034360997,0.14446869304005933,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05541568658898925,0.07991130497284203,0.48848579258324143,-0.212591956659974,0.1017605834819955,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.11428895391809069,0.03545187438902286,0.9404802865694325,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09599617929117506,0.04766030077654777,0.044769205593499145,-0.18973846405382394,-0.0022538945285261736,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07366415690313197,-0.07208899427146447,0.5055162930315735,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034633179433292305,0.06275294140362304,0.5813770629157398,-0.15806093811094854,0.08879457924436393,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.10668564612483625,0.05268888735362006,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09908563729320871,0.04044690264807667,0.014792632093482017,-0.1786400044294914,-0.01953127015692603,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09411753914451632,-0.05047148849965252,0.2647257396604304,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03773088940562369,0.06344474770667584,0.552431833866351,-0.16251935085696617,0.0870575720457188,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08247969588072189,0.026095760161694913,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08286455066937115,0.0349578679242708,0.018319097826943413,-0.15162262303270363,-0.014106478306038672,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07522133808317279,-0.026272678327680012,0.3074355149054478,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01976601919236342,0.059773434598805145,0.7410857621062636,-0.13733343349957608,0.09780139511484923,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09847551751069188,0.05903229934203671,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0964661818127284,0.03471178833379084,0.005751084278238693,-0.1647402441578866,-0.028192119467570192,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.08001730799286241,-0.034111922723864846,0.14446869304005933,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01644285321769287,0.05516926556908708,0.7658497240156804,-0.12495440095992615,0.0920686945245404,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09257456411444359,0.06506560479960104,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12508587869059734,0.06600507610856211,0.0589180437908384,-0.2549102092032955,0.004738451822100809,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.0984023195084509,-0.11797632286305286,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04451541505330768,0.05414626462323093,0.41157084200167127,-0.15101483856601666,0.061984008459401316,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07579900321440414,0.0072896561058186414,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053746659718664595,0.05211550654192107,0.303125240161572,-0.15625181757965798,0.04875849814232879,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.06219691058331706,-0.0060149563851642175,0.8911882060750217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031097193700684183,0.0630211392322597,0.6220161148713337,-0.1550524664060562,0.09285807900468782,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.09523790822396454,0.043865696214774604,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07147137751335031,0.04183182350666312,0.08843806990166134,-0.15374972337792558,0.010806968351224966,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07740045579230338,-0.009670278958384385,0.6595715709697217,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06708272216754631,0.05031988826703917,0.18337283244640712,-0.16605610710838592,0.031890662773293305,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.07212022863962354,-0.004849312323912393,0.8024330451816867,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07137353881374413,0.05186225397564913,0.16965071221689632,-0.17338057824498523,0.030633500617496978,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.055024437089398505,-0.024912016887741334,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023900316293977847,0.06577349370970499,0.9710344796133346,-0.12697880315990023,0.13175886641869577,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.1904153954217912,0.18748751822895282,0.9972922369220661,1.0 +ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09853160386080746,0.06683718588904394,0.14134137601152813,-0.2299925978171844,0.032929390095569486,339,12,351,5,log_other_mut_burden|lin_Esophagus/Stomach|lin_Liver|lin_Lung|lin_Uterus,False,344,0.027334117896982157,-0.08624061000659784,0.7596261630193029,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0017090777636238868,0.07979295404708106,0.9829573806904046,-0.16016207068233038,0.1567439151550826,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06815524813388503,0.08431400702047848,0.9987610176465104,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0982824944296748,0.07099837251789623,0.16958174678232105,-0.042706202531964194,0.23927119139131378,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09076643006635005,0.1972677862079571,0.7842677313995,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02904011080109587,0.06133781434062487,0.6370048611104044,-0.09276463220452427,0.150844853806716,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07344979827303244,0.10304702404489734,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05811338886581981,0.10187129241142624,0.569742193166378,-0.2604095861661839,0.14418280843454434,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.005660154582884388,-0.03530163351407405,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02363476153372332,0.04196381721507346,0.5746421206626128,-0.059697062828846056,0.1069665858962927,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.023266993071708583,0.0553686784127437,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059820532645938625,0.0732590480959447,0.4162657034677605,-0.08565741798023632,0.20529848327211356,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11004857015263902,0.18130288628712463,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02490078116015904,0.061433624164970814,0.6861671954123618,-0.09709422116847942,0.1468957834887975,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.058181152141906466,0.09469375581551598,0.9631430579652833,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04326712594553325,0.06280108634299511,0.49256680392669827,-0.08144338525727515,0.16797763714834166,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.10218197895541827,0.14953459342427522,0.9421219642690486,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01369580399594147,0.04133256884582811,0.7411209295667136,-0.09577409420156059,0.06838248620967764,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.026922269760614403,0.013773186880434498,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02615755404356148,0.06965554538787644,0.7081235604352563,-0.1121645543669314,0.16447966245405438,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0036947077449781198,0.03261096818236477,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040245638821480904,0.047173309593169496,0.3957712779125089,-0.13392248260029413,0.053431204957332314,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.008054019369458461,-0.02502529575687939,0.9210297285457331,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026180369641801718,0.08404277408211787,0.756108332944732,-0.14071192361312407,0.19307266289672753,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0529087970095038,-0.006653672658433961,0.9654293488033827,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030153240493235152,0.04189050835666108,0.47344660421047735,-0.053033007005291295,0.1133394879917616,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.02174776554176011,0.05579638138966114,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018313836513107355,0.03687114641407156,0.6205738822037958,-0.09153262595918116,0.054904952932966454,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0024860349192142167,-0.013567117480463433,0.9580596405456464,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03164864183812782,0.17728484778932246,0.8587040305510122,-0.32040393055793187,0.3837012142341875,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0571372467899005,0.1215109490504378,0.9839047884462332,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058006240580517475,0.13308007245722042,0.6639376985351491,-0.3222768899193394,0.20626440875830446,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.3842045342661061,0.34833828650596044,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010901481339806344,0.03963972272422165,0.7839154831411157,-0.08961811464573105,0.06781515196611837,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0012579865796823982,-0.013744141050202045,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026585463496307464,0.05622576932137672,0.6374393477885464,-0.13823869822768708,0.08506777123507217,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03297777052999733,0.011035506759406918,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018092183610390236,0.039018738008480186,0.6439609061026819,-0.05939129712033406,0.09557566434111453,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.005369376187578787,0.029106793248363613,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0036432247256248146,0.04843414421330645,0.9402011031415705,-0.09982383618069601,0.09253738672944639,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.02778353049114478,0.02566594690284327,0.992787535469879,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09782868604933327,0.07582140282547926,0.20016217982591053,-0.052737593247749,0.24839496534641553,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04350381328842548,0.06169845313294628,0.8152321105480133,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02201047711476493,0.08834677699967755,0.8038039843851684,-0.19744966717233045,0.1534287129428006,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11863462920017263,0.10555353692398887,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019948366758716782,0.052013678750065934,0.7022084382347235,-0.08334049087396495,0.1232372243913985,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06258381156515846,0.07617817272570551,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02375473699921946,0.10428860705189974,0.8203182161383631,-0.18334176810004169,0.2308512420984806,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0235524880030365,0.06391371629711716,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018990014330902354,0.046470023183833864,0.6837353719966832,-0.07329024202024742,0.11127027068205211,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.049533721211876956,0.0617360397279684,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008257259616805072,0.04797050426685605,0.863707769001575,-0.10351717402501187,0.08700265479140173,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03878250726113966,0.04331312198013927,0.9854445582989166,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012985339300050986,0.04109443082254403,0.7527198348410913,-0.06862005598686588,0.09459073458696785,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06603239585491243,0.07205657404181201,0.9654221498691481,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03631936935708509,0.06165872899071673,0.5572635093914002,-0.15876138525710778,0.08612264654293761,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04318963279551083,0.023559051250584537,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06351147419257348,0.04158888574419548,0.1301236443401678,-0.019075810574871052,0.146098758960018,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.011043929848733607,0.06907228258293047,0.7333906673033306,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061795821811500944,0.04131803325538335,0.1381401318995086,-0.14384524721524228,0.020253603592240384,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01232207017460023,-0.038600916619565835,0.751698554752432,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018884273160627327,0.04561560098194549,0.6798367187023608,-0.07169927003179515,0.1094678163530498,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03900474957680788,-0.019191865449263837,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056511651714779176,0.06527627732730137,0.3888659436393538,-0.07311409823551704,0.1861374016650754,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.08570952346826358,0.14474472122636534,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06373978016851181,0.08821353611349764,0.47176194179051467,-0.11143481989553261,0.23891438023255623,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.035070424339093305,0.1126710335979175,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010964939654526999,0.058672584066617066,0.8521590390242593,-0.10554718423731903,0.12747706354637303,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0013632255623791981,0.0013689264152598746,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006623909022048918,0.062020242876813216,0.9151758203902755,-0.12978381985299323,0.1165360018088954,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.012615668514437682,0.010991470195262122,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06157020073467626,0.06859727413593436,0.3717376785996749,-0.07465039070364002,0.19779079217299253,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14978855005301417,0.20378120949816486,0.915561182973695,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16935006269396274,0.04234973166279903,0.00012754935878731523,0.08525188872091766,0.25344823666700783,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.004689453282535513,0.17143387593004558,0.00588655122124249,0.05625597630143159 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1081042124396514,0.053932715506286505,0.047932550278606725,0.0010045281346705431,0.21520389674463225,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0795280742012744,0.18224389444709896,0.5190840165233017,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08255284252838828,0.062205325688521676,0.18772377111607036,-0.04097460608585092,0.2060802911426275,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02098153520434877,0.06409981934451237,0.8085168201280608,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012634997812711645,0.034766900624950706,0.7171157255320142,-0.0816751721529197,0.05640517652749641,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.022473984500906773,0.016988040575757868,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0837179186462326,0.05576510391205963,0.13667601896950973,-0.027020525879518795,0.194456363171984,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.00677966201375684,0.09208924837506917,0.7473242853882033,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05909678278025206,0.04581390669067816,0.20027298046046832,-0.150074121808871,0.03188055624836689,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.00024644861432186684,-0.050976977330868256,0.8152650866129219,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047310481178934376,0.046090723623053956,0.30733523369478816,-0.044216561416238066,0.13883752377410682,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01911205073675161,0.06498375712514139,0.8959335604367346,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00012527731605061875,0.039832370290717276,0.997497303467585,-0.07922447050905167,0.07897391587695042,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02059189088662536,-0.015536435616097985,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024687376076205136,0.03533009960929777,0.48644376778521126,-0.04547119982895703,0.0948459519813673,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.025629067267318232,-8.223716440586282e-05,0.9400644974323602,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015939322712449955,0.04005405724640266,0.6915825486300051,-0.09547874226426782,0.06360009683936792,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.029689488288793465,0.012790791675262583,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019921071958819942,0.03835883925022997,0.6047612233794131,-0.0960941245381264,0.056251980620486516,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.011680609258843434,-0.006827358216545307,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024149492827584145,0.04467067368019449,0.5900676349279973,-0.0645576120145963,0.1128565976697646,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02018638711900012,0.004529069516897865,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05134908924866253,0.048391381587976116,0.2913830421953502,-0.14744478260476657,0.044746604107441516,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.014561390229088504,-0.06488924326657379,0.8798016694357893,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02888142062927721,0.057120874711573046,0.6143201892424083,-0.084549316009985,0.14231215726853944,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.010769895841614915,0.04051446432055825,0.9557595790374268,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03407773287112517,0.0929506060172709,0.7147338306209403,-0.21865921494476553,0.1505037492025152,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.4343866538725613,0.3431704727354897,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02709587167846937,0.08282376489621285,0.7442889584653434,-0.13737571092338202,0.19156745428032074,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.1001422834690824,-0.03545290589869282,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013023305849770787,0.08843405149352383,0.8832410662903126,-0.1625891940560208,0.18863580575556238,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05231921458346889,0.09231436510531635,0.9870713197539774,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0036342523672710917,0.0702329223132516,0.9588422988927867,-0.1358344121891932,0.14310291692373536,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.056481209496461675,0.0689881747497689,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0683244105192225,0.06038702880482119,0.2607783105936572,-0.18824108188278993,0.051592260844344914,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.005436078794885925,-0.057567766509401604,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09368335076576917,0.051895837462830594,0.07427633143995518,-0.009371497424915776,0.1967381989564541,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.016086476088893808,0.08196585434108761,0.624582117553352,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010013761402307528,0.060975195110203835,0.9869323668212372,-0.1200832769397026,0.12208602922016411,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04057815504843819,-0.01664071711462433,0.9990141708527136,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030261915915155774,0.09399707863969774,0.748216689302088,-0.2169214852210746,0.15639765339076303,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03737982782045326,0.0021242309582710367,0.9637098944799569,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004134676630222744,0.052063939764214126,0.9368728850279407,-0.10752334267599081,0.09925398941554534,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.023581771733803367,-0.012250805947982361,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019222061928814597,0.05789453981299165,0.7406223667952663,-0.09574502027254073,0.1341891441301699,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.030444597158381426,-0.018953591225182562,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002199731420076224,0.052591169206446436,0.9667262707129343,-0.10223590780865331,0.10663537064880575,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03608195648703227,0.04623431073690108,0.9962315319978402,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11208209929453114,0.05234495136218297,0.03487070981072443,0.00813539990766432,0.21602879868139796,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.006754490778198699,0.10291524367206766,0.4493241481738629,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08386910763849537,0.05031390526466745,0.09889534373544173,-0.01604433672290513,0.18378255199989585,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.012972757658492888,0.1007889679304345,0.6779844217208436,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043058224000438995,0.07569327806325273,0.5708282301803562,-0.19337007291222916,0.10725362491135118,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.1331909005192814,0.08411377771725417,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004004496956167846,0.055485518135647706,0.942620070654436,-0.11418773953985516,0.10617874562751946,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.13155798349886458,0.13379397331582385,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01964119051004848,0.054232694491943956,0.7180502988597492,-0.08805419260891657,0.12733657362901352,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11014592456223485,0.12938006427364845,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03739697061466114,0.03889768088035014,0.3388345864910116,-0.039846114651383005,0.11464005588070529,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07255199635814004,0.11275813948629813,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045454310347078024,0.07565959162696731,0.5494519565420646,-0.10479064397841772,0.19569926467257379,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.08014892520706635,0.14724465936209574,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008657687293805701,0.040922745014062234,0.8329118927785383,-0.08992214859074198,0.07260677400313058,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.10617376240866404,0.09430131960766049,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0487968472810718,0.06725973104483833,0.46996784545590364,-0.08476764866018024,0.18236134322232386,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.16294845926016618,0.22607949893027054,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04749895034108163,0.02892245554408174,0.10390799426010988,-0.10493321503585556,0.009935314353692305,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04368304503761867,-0.08852882677474122,0.6856372888086054,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03812246003596956,0.04377841578953914,0.3861029645258357,-0.1250577175400222,0.048812797468083105,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0247401929928894,-0.06423687787299048,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02534219455232957,0.038019481370037425,0.5067046843936571,-0.050156960532777975,0.10084134963743711,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04025584232004745,0.0591826759031974,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02416809789281461,0.09307009969946013,0.7956874768130898,-0.16065067495172,0.2089868707373492,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.014931124515966633,0.019363990247580135,0.9735235918682278,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057080057829450366,0.0575820561283948,0.3241200326476099,-0.05726649370407907,0.1714266093629798,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.12634859331644177,0.1796374434738445,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015444917263015653,0.06511553980692092,0.8130291774554362,-0.1138616398276756,0.1447514743537069,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.11264748627665297,-0.08204235361872741,0.9765207460495163,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019801693725899204,0.04108984477243508,0.6310005553749414,-0.061794594574390634,0.10139798202618905,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.004096155507659166,0.026160192790730178,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04454309326432988,0.029006860796090512,0.12803043006834594,-0.10214497006168316,0.013058783533023387,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.08008793347243581,-0.11770070221443077,0.7288842902994255,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019420169234462645,0.03996921086177407,0.6281963503921968,-0.059950762212819086,0.09879110068174438,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.008302758731469918,0.005779820873785247,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005900410799040302,0.028387204059202132,0.835797003033662,-0.062271772124009014,0.05047095052592841,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03227354481115196,-0.03976572799955124,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018337227848851213,0.03388401956566467,0.5896800905908014,-0.08562417537967748,0.04894971968197506,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.044195528621654295,-0.05850839648046351,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012799801516090758,0.026743324320155422,0.6333346612323585,-0.06590674347269418,0.04030714044051266,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.014816073605879297,-0.005012724588004561,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0036719754734673158,0.03831138734487706,0.9238494800691006,-0.07240684702609516,0.0797507979730298,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.013069473956518004,0.011835451157918078,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011256101849250637,0.0355197049632146,0.9747873889343042,-0.06940948437605483,0.07166070474590495,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.003852191938395018,-0.004794340797313643,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051514319461236954,0.04764167902485469,0.28236546776468446,-0.04309261318480084,0.14612125210727475,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.029538883089998715,0.08401415514597088,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00410582836966605,0.0364871708412435,0.910647305548986,-0.06835046168722131,0.07656211842655342,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.013047355434271034,-0.0093749817467879,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0886945518620498,0.04735386426437853,0.06420722241696113,-0.005340837710438931,0.18272994143453852,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.041767972995486555,0.04939856863912089,0.5879399282333936,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12300016332891187,0.06639964357664883,0.0671371297646814,-0.2548566960153371,0.008856369357513383,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06523878726921738,-0.0586887465408088,0.5974602422332298,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008206379536076672,0.04773609799730047,0.8638807156503707,-0.10300080954890596,0.08658805047675262,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.018491946470719407,-0.02075364277416642,0.9854445582989166,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07256823901092134,0.05922636741626082,0.22356793523669866,-0.04504358886140175,0.19018006688324443,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01786467927239245,0.09771344756900865,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01938999668373617,0.04985225294994735,0.6982027906265267,-0.11838669104096855,0.07960669767349621,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.003827294305167949,-0.0205026839587113,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03584144198439571,0.03410585032731135,0.29603291936456866,-0.10356890144417769,0.03188601747538627,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0033903856352080347,-0.030235684689089864,0.8833721946393759,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009890827007630207,0.06001332877186136,0.8694508362522855,-0.12906540416772488,0.10928375015246448,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.006181470916057502,-0.007881057745320445,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02851946176052062,0.05217340134412274,0.585943210421177,-0.07508657328923113,0.13212549681027239,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.028132171351179826,0.056872526719618524,0.952608653969109,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015496297063994257,0.0713065214950034,0.8284354357934546,-0.15709691682346144,0.12610432269547295,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.035475965315716396,-0.047833386593572946,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029350091328186216,0.06755166534826756,0.6649437356294922,-0.10479412828248538,0.16349431093885783,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05242752615487163,0.08667438113409015,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02271405141077782,0.05571384942211708,0.684437323913091,-0.08792261185585229,0.13335071467740792,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05104610244949686,0.08175785722553695,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009036041106567812,0.03965257389248204,0.8202395497356286,-0.06970611207260485,0.08777819428574049,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03149121008304818,-0.021098549009603326,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04971525862399726,0.051816630163349316,0.33982188010099235,-0.15261281681566286,0.053182299567668324,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.022218443994689415,-0.028785889284965355,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0034944472716358847,0.04810138591081866,0.9422426107612953,-0.09202537214261644,0.0990142666858882,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06390598017085965,0.0653113922423947,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0050981579393715,0.05620976428968416,0.9279269905353476,-0.10652329397103437,0.11671960984977738,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03154727199251544,-0.023515206376874112,0.9916764739841218,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011820803047457312,0.042724554689460924,0.7826438819444818,-0.09666330126690617,0.07302169517199156,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.06084603531300843,-0.06859069908678156,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02863021556673391,0.05773825707822493,0.6211614912668978,-0.08602652009637073,0.14328695122983853,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06105403975063935,0.0778199973933196,0.9582992440631078,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05616288235317651,0.10672268226630127,0.599966841819622,-0.15576721372309738,0.2680929784294504,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.08900439300170762,0.15472516582265333,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029467344736773184,0.05190147192330966,0.5715691555328104,-0.07359869237575395,0.13253338184930033,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0779770846474987,0.09916532688753568,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06122018665024922,0.11770460915375594,0.6042178530581317,-0.17251783976414534,0.29495821306464376,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11069761600202083,0.1807673386233952,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026383867475491943,0.05180718262438628,0.6117689223411458,-0.07649492977615975,0.12926266472714365,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09073965997186184,0.10412790765622945,0.9549530254352627,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10497560921733086,0.11811143922748946,0.3764120495866151,-0.12957030109561418,0.3395215195302759,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14386233419136643,0.2538862594599142,0.9168661227448366,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060729036095991624,0.041466721700601686,0.14642297093794876,-0.021615655092036536,0.1430737272840198,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0012933609529624725,0.0525315992398899,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034441202281358864,0.02890556743008067,0.23648627154746138,-0.022959525965990865,0.09184193052870859,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.029341599217219152,0.05269561818346178,0.845523093424569,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08194439356520372,0.038819073669323564,0.03746115829659675,0.004857406641436815,0.15903138048897064,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.001957884269548862,0.0779758999997062,0.46391056873382996,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007185219806611031,0.03174030752698627,0.9819879118614273,-0.062311438294322626,0.06374848225564483,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0010077174776533186,-0.0026990100135804193,0.9987474789101741,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028115180662939002,0.048329613888133685,0.5621505419937866,-0.06785785428274997,0.12408821560862797,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.02748826581455984,0.0691115696825946,0.9512976205783472,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06633188735685251,0.0965693352269911,0.4938653485623282,-0.2580994484607815,0.12543567374707643,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.048061853131465465,-0.019635806938260437,0.9421219642690486,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04165611296773013,0.04228313145262213,0.3270962446493241,-0.04230980618710985,0.12562203212257012,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.055899466394384215,0.09444203720991584,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04851341519680465,0.05717052154908264,0.3982973055334521,-0.16204274061606996,0.06501591022246064,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01803465164668736,-0.025440194108524845,0.9212557438608796,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03440199892440139,0.04029042732716198,0.3953818580938626,-0.04560680476264542,0.1144108026114482,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.10462547187629133,0.13885378540507842,0.920957044807631,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010472022175899505,0.04291006242787029,0.9805821804420254,-0.0841636776053674,0.08625808204054732,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.014173203353383462,-0.005998346902381626,0.9985296925363316,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05938610512496327,0.06055403588518209,0.32927889649294007,-0.06086220920179343,0.17963441945171998,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0635335210508417,0.11970838864915449,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02398277436554658,0.04396576310612401,0.5867242447616507,-0.06332451777969314,0.1112900665107863,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.008200625589392253,0.02254282716258367,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02973164426027629,0.0678562218668379,0.6622888944804751,-0.16448065275809573,0.10501736423754314,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.043675942292603416,0.028308065185049795,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03786183341470493,0.07810284621021288,0.6289801180496635,-0.19295860712451848,0.11723494029510864,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.010008120924392966,-0.03546865069773748,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10035492721589886,0.061829501887062724,0.1079549672097804,-0.22313606424332655,0.022426209811528805,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14175186430142772,0.04459044964056502,0.6967044957001925,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008504256793265205,0.09792182154029122,0.9309795178584144,-0.20295758767202343,0.18594907408549305,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.02854140663517224,-0.02493560654771874,0.9918526261485133,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0055282222512822565,0.04302136974483679,0.8980312121776581,-0.07990369184365716,0.09096013634622167,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11144966946794489,0.12593274799691678,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008632758626763083,0.07023058823967354,0.9024355313893283,-0.13083127092215507,0.14809678817568123,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.01925736880227299,-0.00386311419014099,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004854434644866109,0.03755866667195334,0.8974394410428189,-0.06972963377670884,0.07943850306644105,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07458885546179371,0.07487365777407314,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07540979222571959,0.05823502799115921,0.19855289340284382,-0.04023343201760418,0.19105301646904335,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.06588719621638686,0.13931597093157252,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09689283946783707,0.026125675513756965,0.000354146130386751,0.04501242563160824,0.1487732533040659,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.07121436305627088,0.017790717242766776,0.015033219160481441,0.14366789467055133 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022773656250537566,0.05796035585579599,0.6952793835647053,-0.09232412356803167,0.1378714360691068,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.14103176753162378,0.14858969024994131,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032131991122524343,0.0918967456679174,0.7273895289162231,-0.21462071540235142,0.15035673315730272,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.016960239416040787,-0.037456456652527025,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031259496318208776,0.04279010362066293,0.46690206658098266,-0.05371316908774945,0.116232161724167,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05485222303687603,0.08119744728046946,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035921691762008226,0.032578063972824804,0.27303121573673456,-0.028771886783101566,0.10061527030711802,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.029011547431374664,0.005354455529726227,0.8700354117066056,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004349227828280715,0.05938741445111357,0.9417765241370823,-0.11358240753804798,0.12228086319460942,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04945720645514231,0.05751135010341119,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01771971828651801,0.0328813590910304,0.5912445242707682,-0.08301558082764271,0.047576144254606684,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.024876867807830137,-0.04393998727176149,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002405916558102475,0.05080844003532491,0.9623336701676385,-0.0984895758481267,0.10330140896433165,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05679074340519807,0.06391882487042333,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005588605376822299,0.03585895835019401,0.8764893417459494,-0.06562017917554427,0.07679738992918889,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.03671654970645151,-0.03165503746556638,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01853453939487928,0.04213503652502089,0.6610415145198805,-0.06513729258403474,0.1022063713737933,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.01698357245683386,0.0012205828710561402,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018658282983304828,0.054448167512545574,0.7326127362164208,-0.12678155281752315,0.08946498685091349,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.008886634450367376,-0.011451439361377538,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04091840145431545,0.0446286205535057,0.36158513467375564,-0.1295419971212184,0.04770519421258747,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.020741290582390076,-0.015527282230625328,0.9137080279957605,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038297368004069986,0.04913744409389211,0.4377272614885924,-0.05927985762989744,0.13587459363803742,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07520394110953528,0.11640453272138679,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04822073022177922,0.06523912234978138,0.4616845549304307,-0.17777269775030424,0.0813312373067458,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11226020455720942,0.06710109578442791,0.9370609591482926,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0224249874633154,0.033958015058120176,0.5106462753824915,-0.04500890045068243,0.08985887537731324,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.05697579890745535,0.08446598816221086,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04379313758394368,0.06724745977630152,0.5165080494946159,-0.08974699004998365,0.17733326521787102,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.04983630464238653,0.10926684774269625,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027362633532922297,0.03817254216849445,0.4752849095661441,-0.04844046996346643,0.10316573702931103,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.027798383849391463,0.0586061367512685,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01711608741522691,0.08431964779815186,0.8395859157628882,-0.18455819699779769,0.15032602216734386,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.2184148096757128,0.1935826094636106,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009080747854124403,0.07510063404095176,0.9040196981502808,-0.1582157231911681,0.1400542274829193,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.15923513896080108,0.14574310242069355,0.9884605236688444,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04239551562268065,0.05987420296617226,0.48066866333699587,-0.1612938165054156,0.0765027852600543,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.12240567108677332,0.08459850261477772,0.9390961972850291,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027344468333671483,0.07629531764636216,0.7208540481232608,-0.12416291187456541,0.1788518485419084,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0385171807179523,0.07076992739205133,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05753074440209214,0.04934588408579196,0.2466494755446654,-0.04046040174597223,0.1555218905501565,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11425247413733698,0.16499128276861677,0.8552269457897888,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17667907595007817,0.20576538233836666,0.3927449964239391,-0.5852883455271687,0.23193019362701237,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.19300970058575587,-0.2846892200356802,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03043732325475108,0.0439873841862429,0.49068909795634763,-0.11778755058011901,0.056912904070616846,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.009402450886899021,-0.0366331095874827,0.9419198731133068,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020752361096281067,0.0383300603915142,0.5895181852559961,-0.09686826456573494,0.055363542373172814,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.010184408762515706,-0.027396885665603107,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023203954331792467,0.05041530897272888,0.6464067218657266,-0.07691085769705781,0.12331876636064275,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.1690236591389038,0.1917573160366638,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01469074917770919,0.037056015836890485,0.6926834379368688,-0.0882766526590339,0.058895154303615506,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03662610918916207,0.017805131999953698,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042963526535083264,0.053092391103848745,0.4204530206535436,-0.06246744004689763,0.14839449311706415,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09199468552097746,0.1368332064920448,0.9279200175745067,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0417293703680963,0.05828533428268584,0.47581623279842933,-0.07401375220021406,0.15747249293640667,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.13183640912576758,0.17334531533176806,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045708691798115715,0.02802274583351821,0.10624532437646943,-0.009938927721036613,0.10135631131726805,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.05281663358603755,-0.011444780925075669,0.6896374207352632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0059102745659911525,0.026655297021346256,0.8250103606990649,-0.047021862620925066,0.058842411752907366,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0379833964336491,-0.03910381245354793,0.9805258636366487,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02078685943118465,0.03663704639969851,0.571828066263459,-0.09354077264397806,0.05196705378160876,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.023702953447338262,-0.034996148196860456,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11639104853203364,0.07480299417421025,0.12311239468882229,-0.03215287301761313,0.26493497008168043,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07868664594909355,0.1935559235838024,0.724437501141491,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010609030950169314,0.05322772330352571,0.9841407958953384,-0.1046388064146219,0.10676061260465575,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09262720932991662,0.10830586133485581,0.998871063691614,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0029229882899850326,0.051746234347679824,0.95507505406516,-0.1056807543431718,0.09983477776320172,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.12507703056096287,0.12736316538224882,0.9948722834429907,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0984406485112335,0.07533826811479961,0.19455407805354966,-0.24804751802327468,0.05116622100080766,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.18153925602783139,0.07601753454023423,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012601959330954557,0.06127153803654924,0.8374951536084251,-0.13427509073169316,0.10907117206978406,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.09558008330761475,0.08894086528837337,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001178573194014168,0.03697859866232716,0.9746426173907954,-0.07225359512160115,0.07461074150962949,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0010615924551456814,0.003201580837106364,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22305711522613195,0.10806375286894626,0.041791069823777935,0.008463918713959795,0.4376503117383041,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0697278098343282,0.3034233376137317,0.49032550277088105,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05320241781179229,0.059441878833148144,0.3730803395827974,-0.06483737302319789,0.17124220864678247,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.04794823156424477,0.016659875668978634,0.91574265170323,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010397529356140238,0.028157423058277856,0.7127702015234374,-0.06631259115257132,0.04551753244029085,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.054686851843780644,-0.06371288651038749,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031113410616587678,0.06300593348409451,0.6225995932723749,-0.15623070764385483,0.09400388641067947,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.10733966767459585,-0.12356937783905142,0.9584620018167673,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09756051816682705,0.04056986186787537,0.018164225096176354,0.01699681286184071,0.1781242234718134,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.0723696140109526,0.15373438158209551,0.3061308255062588,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06795695645626573,0.0776714650099686,0.3838669454242132,-0.22219709259595952,0.08628317968342805,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.10964789717833559,-0.15490438188658742,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15545134214403103,0.05552872434585324,0.006224149298174135,0.04518230058972657,0.2657203836983355,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.049867966660988694,0.18850297961052137,0.15202245270432702,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002991630195628252,0.06437858338642453,0.9630358130063715,-0.13083473788940397,0.12485147749814746,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0757803433876628,-0.06814714557863173,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09056333637435221,0.03842129470405434,0.020514733714454333,0.01426625964152553,0.1668604131071789,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03654246856209591,0.11551492031120121,0.3296651866882387,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018030131555266234,0.043833331714845235,0.6817741455504879,-0.06901417809289576,0.10507444120342821,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.06760716842150837,-0.04824594595118032,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0791019353006582,0.041631597214434005,0.060525231470506834,-0.0035701659818793696,0.16177403658319578,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.027617636440315795,0.10307863815254886,0.5719634373962896,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03920949681413028,0.03862716313585546,0.31270329575220823,-0.03749639382408359,0.11591538745234414,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.09340945188532629,-0.05596128180872379,0.9003405011538009,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06934331886211126,0.030102718651512414,0.02347552719002601,0.009565285547196052,0.12912135217702647,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.01689563535277439,0.0835282665738235,0.36184220356199315,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014010691777141199,0.03962211792951744,0.7244331476192115,-0.09269236544980111,0.0646709818955187,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.08851803608459832,-0.09551889919464798,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08258057909611924,0.04600862765711568,0.0759193250800009,-0.008783437180942502,0.17394459537318097,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.11124429049892863,0.16501517477872485,0.6296189902384475,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01447615298804161,0.07137327942076853,0.8397163452774954,-0.15620934075761517,0.12725703478153194,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.0033221871339524493,-0.01177391318616489,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06310447576345511,0.04094824113533011,0.12669340298853457,-0.01821061577735371,0.14441956730426392,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.006092139575788537,0.057986441043748504,0.7263564310373228,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03291228659342336,0.06982102832384071,0.6384728324925721,-0.10573843813155065,0.17156301131839735,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.09738021698120901,-0.055454014427499226,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1014172572528701,0.056978548166381995,0.07835527690908231,-0.011730847074722162,0.21456536158046235,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.03246446855284957,0.1340673832804295,0.6337247675321748,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0031322655860481145,0.04903135602033698,0.949200572775945,-0.1004988213310693,0.09423429015897308,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.013144786222081822,0.005298554709800327,0.9937952805575481,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04908662489377236,0.03137520219177082,0.12109582670970986,-0.01321830854411319,0.1113915583316579,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.053714666313890776,-0.009850613209771687,0.7228579124835106,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004607832200117678,0.066140559641032,0.9944563236831634,-0.13088126011699772,0.13180282655702127,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,-0.045541450038599544,-0.030291868818726055,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:472,TERT,ATM,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0869985922423469,0.06394580906137737,0.17695851671803134,-0.03998511141154787,0.21398229589624168,88,9,97,2,log_other_mut_burden|lin_Skin,False,93,0.07438301818240421,0.15152695353021722,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0596385603924845,0.0888779277930936,0.5025565645888841,-0.11503191869708906,0.23430903948205806,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10895893584773139,0.18651353741275725,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13275904760086468,0.07681062231187538,0.08460810023592068,-0.018195734216473275,0.28371382941820267,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06628000518544512,0.2078386215643642,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06434542502100918,0.043524552004712364,0.14001285081743425,-0.021192734335277352,0.1498835843772957,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.03893872683277191,0.11366783557364771,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13529320150695157,0.06557128041727434,0.0396610150327126,0.006426932351066922,0.2641594706628362,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.13382703614173666,0.2968992252279642,0.4806551714956834,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0906729378008906,0.07618318111103987,0.23460098023117154,-0.05904874308945891,0.24039461869124013,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12446975699168963,0.205960683266567,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01930129957325408,0.06388422754668997,0.7626939899386641,-0.10624942948767677,0.14485202863418492,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04357412698518663,0.06466694234885742,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07165442526988529,0.08054683343730801,0.37415946263326605,-0.0866430771020809,0.22995192764185146,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1011894504936063,0.1762452594831934,0.915842680969123,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09406915054953505,0.06737954211803311,0.16337478027889255,-0.038350868625433715,0.2264891697245038,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09903733530623467,0.17047445630774083,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06112264648801824,0.0518663400961122,0.2392383832519779,-0.040809505826570946,0.16305479880260743,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07981695970444941,0.14186967347712373,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12960720800913733,0.06524563720025271,0.04759355611890549,0.0013809206591050005,0.25783349535916966,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12014086373027016,0.26609228410943764,0.5170078888029929,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0789112387956366,0.04948313431842691,0.11148391534022634,-0.01833723439530771,0.17615971198658092,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09483770647697362,0.18092320910173992,0.7040249164444842,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1234867770972562,0.061825156626193825,0.04639231885905571,0.0019827097114237108,0.24499084448308867,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11776935874909363,0.25212026283695,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09619532162305125,0.06812870257557,0.15865610944513636,-0.03769701153675256,0.23008765478285506,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09601599222030986,0.19831382042381365,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08420741600781348,0.07041406049993539,0.23237378100522635,-0.05417629733436083,0.2225911293499878,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09205206891610596,0.16562981849559671,0.8434307606856365,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05712832433924998,0.07280438896613603,0.4330554425630634,-0.2002097149196323,0.08595306624113234,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.018340617822174665,-0.0538861116295024,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001593752903544239,0.0753352812014577,0.9831310800830362,-0.14964906862197497,0.14646156281488648,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.04273872551945524,-0.07304521061333255,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07160149612162967,0.04941564777900151,0.14804876763446992,-0.025514346769911475,0.16871733901317082,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04969013953246812,0.11241500367028531,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07608446961409848,0.058983130179897626,0.1977397843488893,-0.039834205163172653,0.19200314439136962,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11432772786960478,0.20666605473067323,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08444011146372282,0.048698908807167776,0.08362138791208998,-0.011267134910088808,0.18014735783753444,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07355429636216863,0.16027466021564948,0.6500804664849935,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06543192906623002,0.04903289611516734,0.1827359130175574,-0.030931697632221145,0.1617955557646812,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07761055615443999,0.1607330230447092,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06484808549752687,0.08269421449025698,0.43334320909469726,-0.09766963314882927,0.22736580414388302,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06801089978633004,0.14060326708510656,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09627656428784172,0.06931015817175049,0.16550350882054093,-0.03993766610935402,0.23249079468503747,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08981819242547975,0.2030445757239421,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014314483086318868,0.058597850643922145,0.8071234136733556,-0.10084700750807041,0.12947597368070815,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.002667999120498526,0.02693781279406065,0.9744404042188741,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0989767894436123,0.0610182232075489,0.10549005916577031,-0.02094142361001501,0.2188950024972396,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12053595128996134,0.22200182003651545,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07460931929092027,0.05455195874576202,0.17210122280090093,-0.032600839699052725,0.18181947828089326,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0772108310317472,0.15162630298127422,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054472695546489515,0.05741749155869476,0.34327944201610106,-0.058369052767292505,0.16731444386027153,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10453322493546614,0.15320952795324588,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06467569732546306,0.05063305046982526,0.20214474982117972,-0.034832689097765185,0.1641840837486913,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.02993087365274488,0.09853067650521294,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054949384727056266,0.06356719393808419,0.3878153941786495,-0.06997828286430945,0.179877052318422,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11852216581574161,0.17109229382502095,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0828471901553561,0.06127524952480996,0.17704305430780434,-0.03757615292424496,0.20327053323495717,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05651199657348436,0.13480501231163008,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06873972489483288,0.05205210041229788,0.18731228658711274,-0.03355749942615502,0.17103694921582077,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11725151524146255,0.1925595978592072,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09415346304516176,0.0592233342990021,0.1125860907539968,-0.022237281340448375,0.2105442074307719,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09390570924763904,0.17278280654424275,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06709888545992179,0.08215610243504767,0.4145210506407745,-0.09436128951028006,0.22855906043012364,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07634650717435107,0.14435821948229083,0.9266313996019341,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08505847870178385,0.05493258574579891,0.12222991834198603,-0.022899720910891833,0.1930166783144595,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09614529837307573,0.18676586455668562,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05411882963297253,0.0739190368241513,0.4644689043105429,-0.09115316192349178,0.19939082118943685,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04154884274214445,0.09708377729132692,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1291389577308281,0.06946929468730545,0.0636932071348118,-0.007388021310523046,0.2656659367721792,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07716301688270166,0.21688358544607572,0.5858594185818494,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07598522455627835,0.09041604415515218,0.4011360357387679,-0.10170809190729127,0.253678541019848,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12290815180540828,0.19215748255113613,0.922683406617749,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1352991857244273,0.07771176393677828,0.08236482966015407,-0.017426596421763696,0.2880249678706183,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08919684124151382,0.2174307527094923,0.643528579284767,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0457266997005603,0.07817450516025715,0.558889175182472,-0.10790850093913691,0.19936190034025753,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1463389390781826,0.17543334194216095,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052334674801109385,0.046669474096248595,0.26272400681302016,-0.03938415350266698,0.14405350310488574,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.046311606498219006,0.08894471722754099,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03783838336969315,0.055197322853798865,0.49337674287163924,-0.07064010017213523,0.14631686691152154,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.087626629116472,0.10955708373888448,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022190682584098016,0.050491320699748765,0.6605153016424645,-0.07703916441482966,0.12142052958302568,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05539156233468851,0.07658658538489228,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07536587875482663,0.05447707355752143,0.16721985023237504,-0.0316971094804777,0.18242886699013094,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07980482283401807,0.14906487498581478,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05993691788753193,0.06464521983225309,0.3543401416566454,-0.06710937807514107,0.18698321385020494,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06886087551318036,0.1229006324422792,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05627071872469751,0.060089716139253325,0.34954972718713817,-0.06182271309826472,0.17436415054765975,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09306673964536764,0.12034947327663771,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02682176739522497,0.05048381959402844,0.5954787293972066,-0.07239333779139445,0.1260368725818444,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06667473730024001,0.10125100787831393,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06975425776509162,0.058248047049913175,0.23173151278704215,-0.04471976899131258,0.1842282845214958,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06031213096898282,0.11721735026123753,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058954263782024036,0.06204659840592882,0.34254384242824376,-0.0629849998636358,0.1808935274276839,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07396318866104615,0.12549991136565125,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04082664997376286,0.04864985154782104,0.4018091789746008,-0.05478418489265107,0.1364374848401768,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.043059266136677044,0.08533896602637481,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03569868791227775,0.05516483826782299,0.5178815552527885,-0.07271595415241086,0.14411332997696635,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06249555207875507,0.0789753228057112,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034840504125209344,0.059334589745309876,0.5573745350069761,-0.08176888894619308,0.15144989719661178,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08286354787648571,0.11358207209290007,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024755216688806675,0.06531363360526402,0.7048524898713647,-0.10360470299193594,0.1531151363695493,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.09062828613906125,-0.07918614295402883,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03322193422354919,0.052907527210516156,0.5303740387557756,-0.0707564477524494,0.13720031619954776,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1552529686472957,0.1533210270819243,0.945915518526879,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1034881720451974,0.07932460310168285,0.19269480132804784,-0.052407299096040125,0.2593836431864349,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05379883178568676,0.17230581815320864,0.8136230494372573,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0961459325888345,0.05386843491346553,0.07496712206856626,-0.009720907106675308,0.2020127722843443,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10117381831115341,0.21255888221455296,0.6283938912146557,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05647684785404759,0.0678522334591435,0.40565553324524917,-0.07687214463368174,0.1898258403417769,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1050700787964969,0.16147740957242215,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08235088701601385,0.08481749369000838,0.3321138581334425,-0.08433968088853937,0.24904145492056706,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.14559990218512206,0.21156325717662616,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04588669397519633,0.05784878781422356,0.428071710652998,-0.06780267450090689,0.15957606245129957,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07025727797908798,0.10097115205384546,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06172951856021669,0.08147966744350688,0.44908583087945486,-0.09840126870958285,0.22186030583001623,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.14419204043093165,0.23520336223716629,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027249244850281813,0.05431197079844481,0.6161135468190426,-0.07948926937057363,0.13398775907113725,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09688416336906466,0.12389514108808965,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04126884783534019,0.0733620122507976,0.574032189196348,-0.10290843155232943,0.1854461272230098,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07981034000095817,0.12097738953094633,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025401255150320157,0.049079457539920227,0.6050257128501866,-0.07105387802865577,0.12185638832929609,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06954791478584212,0.06413355259442605,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03249911183379611,0.04172715037326177,0.43648130741555535,-0.04950664063725416,0.11450486430484638,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.035513453800443684,0.100281775917019,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09290151656433929,0.06862093479091541,0.17647268568875926,-0.0419581932998119,0.22776122642849048,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07364994052932168,0.14456157262404876,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08831369679910182,0.0725105204755344,0.22388804476167157,-0.05419015837606479,0.23081755197426845,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0910325168621969,0.20632050734473123,0.8356888710841501,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01574493567334294,0.07797233318995819,0.8400634897283186,-0.1689828107251528,0.1374929393784669,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06593768503702374,0.059511464695420915,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08350169278024226,0.05976274921471691,0.16304066003825068,-0.033949155774035136,0.20095254133451967,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08641275321107696,0.16330969493431788,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045258459722101615,0.07857510839954363,0.5649119619138715,-0.10916404054831945,0.19968095999252267,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07121417120616484,0.12800877824360726,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08437855934403636,0.061936550515941435,0.17377706008060428,-0.03734442880843644,0.20610154749650916,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.12295475367863136,0.17659143242615588,0.7883592203510926,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1200372227511417,0.08635578499263169,0.16521125120170668,-0.04967652633551617,0.2897509718377996,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08035114386486487,0.1849745094241193,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01640923549626054,0.07055091407580133,0.8161884671884942,-0.1222434341577359,0.15506190515025697,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07932511073449074,0.07503475235806957,0.977947781515814,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05054332538075898,0.06457666871396217,0.43422532120130997,-0.07636824808138637,0.17745489884290433,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09079604743891757,0.13141194867236355,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08956451017817135,0.07875416015845035,0.2560359244999838,-0.06520987787008897,0.24433889822643168,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1033345344552919,0.1711755035758255,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030916461538584065,0.06534745806088813,0.6363664568726419,-0.09750993284533302,0.15934285592250116,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07252413763401064,0.08519096067183246,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11907595036785162,0.06203674691288834,0.055564675214566074,-0.0028439522840063014,0.24099585301970955,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10989413206633167,0.262418022331961,0.5506521745982841,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018039733305575095,0.06366069685806205,0.777021987693881,-0.1070716941937267,0.1431511608048769,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0658267274185911,0.05966545122300578,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052562945646756454,0.05246373250830548,0.3169382414107979,-0.0505432531542134,0.1556691444477263,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11347123326491632,0.16773157440392691,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05079007659183311,0.06486638153805975,0.434044456701562,-0.07669086520551155,0.17827101838917775,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07587697638470306,0.11792278756884636,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06169465725618403,0.0635762321324081,0.33236972713969704,-0.06325077296502536,0.1866400874773934,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0928576584628594,0.14431711273730188,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052284836683072926,0.060642945033421984,0.3890534688065058,-0.06689584771642995,0.17146552108257582,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06436946700811753,0.10733432740823665,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07071297733377767,0.060157081760548944,0.24043156823657896,-0.047512847149972795,0.18893880181752815,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04592867528703033,0.11520330542676602,0.8475547497769944,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05114502264352388,0.05704815092553563,0.37045566092218163,-0.06097086597772192,0.1632609112647697,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08799577052468582,0.13618675964029184,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048464235672060624,0.06750593235729385,0.47317821189092435,-0.08420417637380534,0.1811326477179266,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.040659301737466236,0.054528386263553566,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029462007122766854,0.06108174849227833,0.6298024367329531,-0.0905810512349029,0.1495050654804366,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06426919343766553,0.0807826063851231,0.96007126858481,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03715510185409495,0.05988272734871537,0.5352682727247824,-0.08053153795529105,0.15484174166348094,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04201811347699973,0.052904459107437914,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03553601807342381,0.053423083179939636,0.5062778052312524,-0.06945557843640514,0.14052761458325275,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0628047392658118,0.10410795250235923,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0584957570290575,0.06763368954246515,0.3875626265867227,-0.07442373432631887,0.19141524838443386,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07763866678818804,0.13377871269910774,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14889008750475186,0.10108045163491278,0.14145860148380354,-0.04976183150446534,0.34754200651396905,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05439723512253013,0.2146265853180443,0.7597417987675457,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05625512585668375,0.05816497934165327,0.3339845928157793,-0.05805564915928373,0.17056590087265122,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09581212408010274,0.1850710655436864,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1122362474515645,0.07011636536558968,0.11014674783046931,-0.02556241003894942,0.2500349049420784,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10718982052328556,0.22179108340296844,0.7000359361715495,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008958908757723892,0.04947545911911237,0.8563885601475992,-0.08827448047734221,0.10619229799278998,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.036323587935133975,0.03173265640837603,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09306145605780802,0.07826463516643081,0.2350467739036926,-0.06075087575213148,0.24687378786774752,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08439142234988999,0.18646831063789537,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056043399754492323,0.07070735484419219,0.42842518634155236,-0.08291672063156424,0.1950035201405489,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08531126660600853,0.12729265914064808,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09299823350975386,0.05691398751048106,0.10296004005559176,-0.018853985732988535,0.20485045275249625,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07388648315255852,0.17693072382869993,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06776447940447708,0.08506763382004746,0.4261089708528426,-0.09941768520398636,0.23494664401294052,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1062634161800795,0.16805039361457738,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09828743595738018,0.05850645645421294,0.09366735520643399,-0.016694438985531787,0.21326931090029216,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09592097695656811,0.20519902600296575,0.6704521782043941,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012943245683839734,0.06043067287076341,0.8305017249097697,-0.10582026336887435,0.13170675473655383,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06828373348516927,0.0580533829039965,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06564003600263317,0.04258616698975511,0.12394009285407884,-0.01805392914027526,0.1493340011455416,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.052097497716361484,0.11503220726090481,0.7255813269452924,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08847148623291905,0.07744019342041909,0.2538789132301119,-0.06372058238757532,0.2406635548534134,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1144863582374713,0.2062118996673602,0.8634493629908433,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07134668962272485,0.05638662050824886,0.20641853739058758,-0.03946910303781398,0.18216248228326368,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.080723243067799,0.16112166699559183,0.8202168117716766,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02927657077658807,0.05871087948031108,0.61826657078842,-0.08610705372093352,0.14466019527410967,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06169584620775727,0.06770756749927047,0.9572656024379023,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05261357116849887,0.0735716146820976,0.4748995184704663,-0.09197563678234269,0.19720277911934045,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09398349561340709,0.12290076572392296,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02398000880002344,0.04637311024537714,0.6053349975410713,-0.06715638000384627,0.11511639760389317,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.049880768059877956,0.0863772623725138,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036468122732290865,0.060826677802496405,0.5491155523013838,-0.08307364896521241,0.15600989442979415,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06627770453167253,0.0793325156561595,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011775938777100372,0.05847287653151477,0.8404840926152621,-0.12669181959378636,0.10313994203958562,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.00017116498369935945,-0.005294940432663009,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018784074030566592,0.05498547075976346,0.7327982770139565,-0.08927805971913524,0.12684620778026842,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08140742052237397,0.08668137325546203,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014555422222847204,0.05338463789126383,0.7852467302442628,-0.0903606183288436,0.11947146277453802,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.021609572392259094,0.04199808166253804,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011168331208617259,0.062028523415116395,0.8571937002018886,-0.11073540992450048,0.133072072341735,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06565055561233459,0.045957092581553886,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012972262883837333,0.05336080675470069,0.8080358081376261,-0.11784146845473939,0.09189694268706472,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.013663564615856634,0.014271946405986526,0.974516576191754,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0372695214088813,0.05217039940993981,0.4753647441044888,-0.06526019418532841,0.139799237003091,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.03519671220988522,0.05047471159189446,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013050574354779434,0.05953964389282554,0.8266010507486358,-0.10396180860483513,0.130062957314394,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04354829019667135,0.02621877841632092,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04837935654659003,0.056485458919739474,0.39218448136056605,-0.06263068178456918,0.15938939487774922,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06583326463517446,0.10147311308270544,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06808193154514057,0.06855636226838807,0.32120838002813995,-0.06665087489398781,0.20281473798426897,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08234301565105945,0.1303384088248091,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08039330165698125,0.0828899043303321,0.33263055626002924,-0.08250900334245073,0.24329560665641323,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09500822073282515,0.17892752351586683,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06720735105356666,0.06711310671374013,0.31717318233940517,-0.06468904655562234,0.19910374866275565,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10022688695567776,0.16550124757463597,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03206779752204755,0.04826858152175215,0.5068013886590139,-0.06279373299209814,0.12692932803619325,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05255292848178556,0.067314004117468,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06751019011466426,0.06290154618650505,0.28373012945113496,-0.05610928977970768,0.1911296700090362,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0807007392777174,0.14386104113132692,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07967960327583025,0.06731384880210199,0.23715975623622002,-0.05261130979538929,0.21197051634704978,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10510044583270782,0.15691575336767413,0.8457206401631242,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06541247924366063,0.057503979282347926,0.2559263233859541,-0.04759924211630935,0.17842420060363062,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10191574596835855,0.16460974822826507,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08625329474730674,0.06786719844860215,0.20442064748078706,-0.047125108213227476,0.21963169770784097,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07324624701408322,0.14789864998889762,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07211473358342617,0.06136714446064333,0.2405659327145593,-0.04848920925661583,0.19271867642346818,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10525215728851452,0.17184679223208968,0.847586495289912,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06517685681864639,0.058212281323849355,0.26346802597970415,-0.04922688008445364,0.17958059372174642,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04702460379483328,0.10990260575892705,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07420645816900602,0.06578374167088183,0.25990962002270374,-0.055077357951317144,0.2034902742893292,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.13064564302901943,0.21115154912951392,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08193075138668872,0.05914877054451067,0.16669315951914046,-0.03431345395325357,0.198174956726631,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10400674426215592,0.19895481465376658,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06572374587958983,0.047478775621804706,0.166964531973395,-0.02758559076193598,0.15903308252111564,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08524536766429924,0.15373723838739778,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046289146191887426,0.07169341370091346,0.5188346837087663,-0.09460886110479766,0.1871871534885725,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08515988355811585,0.142901331828649,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.078044414826232,0.05554307135703288,0.16068159490067263,-0.031113563143560327,0.18720239279602435,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.09882341653638341,0.1806406775718836,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02729138090272515,0.06317805963516439,0.665967432339136,-0.09687152678920387,0.15145428859465415,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0932191928297913,0.09808419108743882,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027387668556184845,0.050011267906501795,0.5842193459293711,-0.07089873777679997,0.12567407488916968,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.012261504296026399,0.010997748434330478,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04301764622145384,0.09951245217645478,0.6657434362571766,-0.15255270660567768,0.23858799904858538,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0987115126425834,0.061910444887612374,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05916175624035555,0.05845740431921825,0.3120621314821462,-0.05572371726597211,0.1740472297466832,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06648115127785556,0.12230576554690378,0.8991467149565432,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07774417028556221,0.07186630702857431,0.27992960658168115,-0.06349362171497211,0.21898196228609654,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.1478138985096304,0.23848637422513216,0.8758370884717323,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028275520530609357,0.04067871595737214,0.48735772495184426,-0.10822080032565659,0.05166975926443787,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.010281965265606707,-0.01327565436231267,0.940275458344982,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07024853582680829,0.04911688411607742,0.1533490737240681,-0.02628015124963562,0.1667772229032522,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04874991969467188,0.09475824577906206,0.7704335108997802,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04770576132401481,0.06569748024653364,0.46813118640373097,-0.08140852649280289,0.1768200491408325,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07645924816382833,0.13975043775794344,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032375216764912104,0.050023659122155395,0.5178359621455202,-0.06593554184122377,0.13068597537104798,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0481516211252066,0.06627294469977435,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030248452340423206,0.060335069860721485,0.6163778652405871,-0.08832716952836256,0.14882407420920898,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08118950675237899,0.12482002458993957,0.9561867293882707,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027513661398986814,0.0613389246159048,0.653972642077433,-0.09303482139689455,0.14806214419486818,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07534795959205619,0.0637812766603308,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03522302124278487,0.06977908517614731,0.6139627756332852,-0.10191278447181379,0.17235882695738353,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08709938436092884,0.11077085337726808,0.9556150025445134,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11908915987390842,0.07267362469809584,0.10198255464095203,-0.02373524162140489,0.2619135613692217,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.113487337104035,0.24658485274142777,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09929765974510275,0.07261985566196895,0.1721988921193657,-0.043421070257482555,0.24201638974768808,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07382182582274126,0.17616241120466486,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012831852685774562,0.04467105420106486,0.7740524345181362,-0.07495951050735593,0.10062321587890506,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.053074546735900216,0.05999780711538765,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1095026211860892,0.06665272676135867,0.10111038190433873,-0.021488998500813983,0.24049424087299237,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08502969744018833,0.21099808426962954,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05324980490277462,0.060889811366912766,0.38230075748446835,-0.0664160422566241,0.17291565206217335,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08860513834124699,0.13462044411503252,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06564809765198514,0.06001895699952096,0.2746364345933413,-0.052306272278514976,0.18360246758248525,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05817490580515955,0.11099777999232975,0.8709804306040525,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0947108455849034,0.09397934258775564,0.31410354484075265,-0.08998536867136585,0.27940705984117264,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11720976431986421,0.20839824356954126,0.9014294790115309,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017402073797502266,0.059146673017546565,0.7687271534124003,-0.09883800930367027,0.1336421568986748,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,-0.007322268977099654,0.014850223980530129,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050207167037185224,0.06756830570442048,0.4578369283813609,-0.08258382642676229,0.18299816050113274,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0618731042080834,0.11632186556547675,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05224629297030548,0.061444729512347016,0.39561498365214165,-0.0685101266262021,0.17300271256681304,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07693412590729697,0.16205244611703334,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06294769340782258,0.055766485575418315,0.2595991066308491,-0.04664935722635109,0.17254474404199627,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10529757270910181,0.19521611413835765,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017092428079625386,0.05799852793156797,0.7683564302411602,-0.0968912224379805,0.13107607859723128,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.01581267444533854,0.060758123003055234,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0022399402322220503,0.1303628441108614,0.9862988079440341,-0.2584401127804954,0.25396023231605125,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.2514307185696037,0.18650688788082556,0.9990098172080826,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03023148232321841,0.06949359034387538,0.6637538876829884,-0.10634324461323157,0.16680620925966838,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11713134443729861,0.16091335219104622,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025270796483390954,0.06882365961676748,0.7136571683816431,-0.10998732548750248,0.16052891845428438,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11798840950990223,0.15109591322568225,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032281289785726884,0.06539285157971823,0.6217946689750413,-0.09623431581045064,0.16079689538190442,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.02773103011922657,0.048790203392983574,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03449464050691881,0.06671425038373065,0.6053766021162666,-0.09661789064655296,0.16560717166039057,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10318900724039894,0.13482477354989444,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05226222826909526,0.06165537246460228,0.39708608490296216,-0.06890816481105297,0.17343262134924348,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.031450203182821275,0.06906866984302176,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03703038203243396,0.06621934856046903,0.5762999109655255,-0.0931095258756731,0.167170289940541,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.03352203127147477,0.05639975802241563,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05483333868199224,0.06685313784591075,0.41253588498749993,-0.07655214595004181,0.1862188233140263,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06943925198293208,0.1257139590336073,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040836555572592005,0.07041639443811888,0.5622542437897347,-0.0975517446238306,0.1792248557690146,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07462044496193716,0.09105781581692468,0.9512976205783472,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08478948021269815,0.0643110834678909,0.18803582657321874,-0.04160014248706685,0.21117910291246317,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10607563803217841,0.1735526378322332,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06279033445644551,0.04914275799424705,0.2020138485888791,-0.03378920217070254,0.15936987108359357,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.02769969567899505,0.09241325664056513,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10829464995990269,0.07728130538827087,0.16181690124728015,-0.043585158357206374,0.26017445827701174,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.11173549052128837,0.22903477153918,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09206876669629566,0.06363960338852706,0.14867586784742987,-0.03300120611880247,0.21713873951139379,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05896729090101385,0.13755267880392796,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08757077619677474,0.061068797993719684,0.1522801951329106,-0.03244683073730925,0.20758838313085873,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08638763167423713,0.18266258308908864,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11804190201481425,0.057284586880752435,0.03991714421570559,0.005461349302075882,0.2306224547275526,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10441053250743107,0.2232703903050361,0.4822865917568812,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05401822771075977,0.06288828545871626,0.3908255424004349,-0.06957519107110136,0.1776116464926209,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10352075220864244,0.14701069801885258,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0259597785853753,0.058779209833674906,0.6589567974942612,-0.08955813454662262,0.1414776917173732,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.002148618554249235,0.023853732986834755,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07108804202368402,0.08043344449933118,0.3772728180040884,-0.08698661874281655,0.22916270279018458,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.10391374889571972,0.167467777740159,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05628617304897765,0.06150012327811603,0.36056933495613386,-0.06457911109743228,0.17715145719538758,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05141491538773658,0.07161386015880786,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018523256260503867,0.06147336023602844,0.7633093292974314,-0.10228943087448364,0.13933594339549138,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07987841105970656,0.07361368268734773,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03944794727539895,0.0765918064297564,0.6067787168012421,-0.11107679891992149,0.18997269347071938,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04772306679367373,0.029958188304012815,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01668510670471145,0.05359515510322915,0.7557044426970203,-0.08864466021508491,0.1220148736245078,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.08921889741125397,0.0859140395217671,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008065230802632757,0.07755449645813431,0.9172204610644441,-0.16048193749531067,0.14435147589004518,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.030447274085708322,-0.044917199570581,0.9899246798000758,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045632407776926356,0.06393575840984886,0.47577109346487256,-0.08001959412844813,0.17128440968230085,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07529790404239925,0.09529959314249203,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049725084712092346,0.0756045389830253,0.5110696359555273,-0.09885939934849973,0.1983095687726844,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05425480627263469,0.055357668035809666,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04181399108133966,0.06932703756018573,0.5467206722028587,-0.09443341212870099,0.1780613942913803,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06741328253169812,0.08971320750154568,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024677608951288725,0.05481433647463165,0.6527819368437913,-0.08304819711487155,0.132403415017449,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.043558639608581896,0.044325354116400026,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04079832874566448,0.0725328496198371,0.574070511697113,-0.10174940956708038,0.18334606705840933,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07718198450330707,0.09939112136834262,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0251343631828986,0.049815135234576965,0.6141216323260411,-0.07276658650611517,0.12303531287191236,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04373983537287701,0.04257301257620012,0.9556748710849078,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03525858939027902,0.048566925603354405,0.46823131359861936,-0.06018927234198778,0.1307064511225458,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.06837272209708402,0.09498595967147151,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003988195585357384,0.08849850302238904,0.9640755288122411,-0.17791299677578254,0.1699366056050678,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.061767657549030276,-0.015619909417965643,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03188481458603509,0.0710832318157191,0.6539692908455809,-0.10781401126183407,0.17158364043390426,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.05943870664728394,0.0714357726468478,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04402354594346675,0.06145796993622322,0.47416811280167337,-0.07675889486257204,0.16480598674950556,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.04159663199566561,0.07373950112453978,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0484352880460089,0.07266684547479167,0.5054105029037675,-0.09437579034184908,0.1912463664338669,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.07180786364953444,0.0948653463829716,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006389327631839422,0.05555495750108161,0.9084895246627797,-0.10279201000133695,0.1155706652650158,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.038488360871973895,0.021073686555432222,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030639055812316192,0.07117553281299452,0.6670599914400757,-0.10924116782254994,0.17051927944718231,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.0457610781428965,0.058742655158679095,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04551543645624595,0.07383301177939854,0.537901761260383,-0.09958749135004127,0.19061836426253317,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.034873605089030084,0.06211552409101248,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03919827799971455,0.06164828037723935,0.5252078496921397,-0.08195817710586352,0.16035473310529264,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.13491165699602548,0.17077907890291075,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12148636889685684,0.05435398930311252,0.025904308663204454,0.014665276329237711,0.22830746146447595,442,13,455,6,log_other_mut_burden|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Myeloid,False,447,0.016013168970623257,0.10949872200682977,0.37799338633918556,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0772187326640555,0.06766919638525254,0.2547514257761107,-0.055960569690112746,0.21039803501822374,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.049364215385923435,0.15720510248541628,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006053040125290443,0.0805349805663038,0.9940082401912622,-0.15789506395200492,0.159105671977063,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04256075999826988,0.05741843053501414,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08741055253363095,0.05830145345520974,0.13487612143719696,-0.027332156293498097,0.20215326136076,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.057649951090653406,0.023223290001411198,0.7471365331252404,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014503886673832584,0.09095500706278785,0.8734145935780223,-0.1935118405628852,0.16450406721522,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.20733393677609172,0.23526618106827119,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016131620885967896,0.051167324683347275,0.7527796234574226,-0.08457045581465777,0.11683369758659357,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09454920367339144,0.06620821605264261,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08749776229424751,0.05106032457538431,0.08765703941299592,-0.01299372819445982,0.18798925278295484,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0860074865782966,-0.013040011600410783,0.6570553152600204,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03915783132856598,0.05222884618105636,0.45401544676867667,-0.06363341888158372,0.14194908153871566,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11870192473212554,0.1425235183052785,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08202629275526412,0.0534162835193605,0.12571448791605894,-0.02310194510587385,0.18715453061640208,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04786794394076957,-0.005139775383334766,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018929098759622825,0.056728956203520704,0.7388626346940925,-0.09271878852209425,0.1305769860413399,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06588171587989981,0.0655162301629403,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003197563862376406,0.07608577559364262,0.9665067725663816,-0.1529414806505691,0.14654635292581628,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.19649561356187956,0.20319538706674214,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1016081088740341,0.049677925221575076,0.04171459986264683,0.003837309502552594,0.1993789082455156,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.038850214523377835,0.16795149547112864,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03255822713314562,0.08184700995092611,0.6910719065732569,-0.1936407915392831,0.12852433727299184,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.21286260781061178,0.19002427174176695,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07781712389026643,0.0836969250179137,0.3532664661941538,-0.08690624624722981,0.24254049402776268,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06500184780928661,0.1546237277885549,0.9092831415853414,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03800633159162398,0.05774490197549281,0.5109415903401795,-0.07564103191219287,0.15165369509544083,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05022108709328045,0.06574930148349126,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06052150032704168,0.11296871802975592,0.5925468908395918,-0.28285449463945067,0.16181149398536734,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.06473209978992078,-0.11525710402788618,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22679328043225502,0.1373008438797697,0.09964695802925122,-0.04342761145543664,0.4970141723199467,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.31633883152078945,-0.12599350604492335,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01574039102956184,0.05053992861282688,0.7556840855240823,-0.11520769363155697,0.08372691157243331,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07567073766998697,0.037865403139406756,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020178082268061046,0.0574604866647634,0.7257173242071702,-0.09290952532486632,0.1332656898609884,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04615142599786361,0.08092671356503553,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0370885431710271,0.052071741009455524,0.4768714511818192,-0.06539350937951227,0.13957059572156646,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07498357651970432,0.10334629402052013,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0046706081666336215,0.05865237012868651,0.9365842683435295,-0.12010395380126974,0.11076273746800251,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.014926856498667432,0.039336866123486636,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14692747379152565,0.1166593410315737,0.20886751192409908,-0.082669011487084,0.3765239590701353,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04963830319036385,0.18964829969293706,0.8221680401162432,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07799387093677881,0.07418992720733318,0.2939994611992004,-0.06801883905503772,0.22400658092859535,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.037232790606117325,0.13965437730314176,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09335989816640292,0.06555726683662928,0.15548253745250284,-0.03566292947059113,0.22238272580339696,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.09055577108794405,-0.013683093434961022,0.7742913314290888,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10257541389571753,0.12538331299181532,0.4139679659812001,-0.349341491270673,0.14419066347923792,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.16762000034471533,0.09365670725596459,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005964397613894069,0.05513663763066073,0.9139310324606867,-0.10254965790999099,0.11447845313777913,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0372043815954479,0.042816856834138224,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06007584973268969,0.06441461881930137,0.35177215716506727,-0.06669813982267951,0.18684983928805887,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.014873475998663076,0.06248173511824557,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034692007809651426,0.06043111196573596,0.5663572900103326,-0.08424206798849593,0.15362608360779878,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04563560773244147,-0.008302163915653558,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07390251173351095,0.05815831061382643,0.20483882397253736,-0.040558478604693096,0.18836350207171498,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.023964970319314566,0.04403372805945471,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044370120248184826,0.06824210630639971,0.5160809959943877,-0.08993672237077058,0.17867696286714022,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.011981846608910308,0.054884403539725825,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01018961652628998,0.05609526541531089,0.855984243863295,-0.10021110806412552,0.12059034111670548,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08481851150204651,0.08654141716314705,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013295995646102204,0.06769968572685732,0.8444358195076718,-0.11994331258165505,0.14653530387385946,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10042841790607647,0.11440101259424831,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0250485047929886,0.07933809442413703,0.7524409442705842,-0.13109627939153934,0.18119328897751652,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09192752295989078,0.0945360914065177,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010268773765442902,0.07064564581929149,0.884529685897339,-0.12876845923210084,0.14930600676298666,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12601964488877027,0.135978055247967,0.9880940960671373,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05099685475306133,0.06784321726669323,0.45284276133623547,-0.08252493695850056,0.18451864646462324,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04096497311812287,0.09174362421405306,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15064360543398744,0.10451733854888934,0.15056034855506906,-0.05505628425598452,0.3563434951239594,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1241341028081861,0.2735366956387101,0.7680900043895489,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004044238668912755,0.07225850414595375,0.9554046220882428,-0.14625572757926655,0.13816725024144103,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0003284385507804202,-0.03738748302678513,0.9950146798919537,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010235885876732187,0.07331038800636856,0.8890530432230792,-0.13404580877228742,0.1545175805257518,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04628453869566819,0.049085335604089855,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03143493723146144,0.05669185969392165,0.579668127332699,-0.1430098151155192,0.08013994065259632,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.045682581965206415,-0.10728236412934357,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006475326887858065,0.050991361880578935,0.9898766820398989,-0.09970823277179566,0.10100329814936729,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.015620526674525155,-0.03330547565859212,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022231722818387502,0.03606001436090965,0.5380300376787558,-0.04873775534899111,0.09320120098576612,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05921641183187902,0.052251405891525354,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024081342962807447,0.06161955965369143,0.6962240532621486,-0.09719170894886188,0.14535439487447677,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.013221093746906165,-0.014434664632473122,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004025750409305979,0.04858273961656402,0.9340164196572545,-0.09158962134348009,0.09964112216209203,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09986811788753065,0.0984269087998112,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05942373828910711,0.05288079813729766,0.26204743610011033,-0.04465061429758526,0.16349809087579947,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05817172273519555,0.08426397843881189,0.8670831795592645,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002832286622931867,0.06301677138672511,0.9641817914116467,-0.1211906085525336,0.12685518179839733,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08218352024030823,0.06531969731236395,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015877023216516673,0.04034060694753362,0.6941816561404593,-0.06351706119420203,0.09527110762723537,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.01884709350597936,0.023258607646486483,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031078148647677377,0.04500495724526946,0.49039538349153233,-0.11965211034039222,0.057495813045037474,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05237951221964027,0.006351778081495045,0.9418332435783486,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010527378288728662,0.0551999708532998,0.9847971689718636,-0.10758596339582549,0.10969143905357123,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09623933736966046,0.07869826884852363,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02107890711331835,0.027000123724432223,0.43561118155050005,-0.07421767383701736,0.03205985961038065,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05104520721459685,0.022664875479934884,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01585370444027199,0.0492729382119272,0.747869417827015,-0.08112004264909967,0.11282745152964366,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03541090760998107,0.016662099170513617,0.9635753025013546,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,5.949588805353057e-05,0.03916790843359597,0.9987890508500723,-0.07702660825541283,0.07714560003151988,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05071320051454974,0.0371017021744656,0.9996705945842735,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004154826502200757,0.06190401599077777,0.9465341473852787,-0.12598771506846404,0.11767806206406253,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04634048898531282,-0.05054641723290725,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044824781476998955,0.05760509500789974,0.4371148683960884,-0.06854742884925843,0.15819699180325636,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.05228982971496168,-0.0525993689263389,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21576356570581273,0.06060347353947164,0.00043215058183657443,0.09649026622290197,0.3350368651887235,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03591244716109433,0.24322110074981618,0.017682532570199628,0.16898657564190503 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10964527274002023,0.09015715744269943,0.22490391143504798,-0.06779243853551037,0.2870829840155508,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.019330817121530553,0.1085357380500978,0.8381630276861085,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0830353882959845,0.034936367998888614,0.018107684359713935,0.014277351176831113,0.1517934254151379,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0846238605303426,0.14309312592872192,0.30582723073916857,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07325254326101688,0.09062046866933146,0.419548208146704,-0.2516020943282367,0.10509700780620296,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.2065534947316064,0.11799066467025135,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05982933847575303,0.04321709092356193,0.16729228193982448,-0.02522593521493592,0.144884612166442,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.028620328224568777,0.07194162940951204,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04806705097628432,0.09061530053380638,0.5962004960016164,-0.13027232871724603,0.22640643066981464,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.190494832475974,0.2732361321708096,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02512552196942687,0.05716471973454263,0.6606026512838861,-0.0873799886646127,0.13763103260346643,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10855855647354863,0.12252506833647797,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002746358049237217,0.08614963230927924,0.9745903065039798,-0.17229688534821905,0.1668041692497446,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12494951080520988,0.12503326194154674,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008013371825435016,0.054403677659674035,0.883000740879955,-0.09905814997847205,0.11508489362934209,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.02097465673600001,-0.043939776266197494,0.9870713197539774,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016529643303118922,0.056764300646142955,0.7711060264912531,-0.09518780514471176,0.1282470917509496,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06304794934559724,0.08594773264755935,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033911476037758875,0.05368627992737358,0.5281015689098574,-0.07174813998623769,0.13957109206175544,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06690170738390068,0.05798539956269923,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07168223913841903,0.09216145378946827,0.4373205177234748,-0.10970011465442472,0.2530645929312628,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10358125310996723,0.18383151639942721,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1141913748471777,0.050493188387974564,0.024459998510759078,0.014816061375691358,0.21356668831866404,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.015163943244322485,0.06812531164337327,0.3691320687802387,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02247834875296162,0.05769241866179115,0.6970976802670832,-0.09106572268478386,0.1360224201907071,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.010507557872841205,-0.0068989896802377215,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06135827276024269,0.05400012702211683,0.2567755781815114,-0.0449190236760618,0.16763556919654718,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05017749856329354,0.07549892875344032,0.8647791852375212,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08999317705025367,0.04636954981834189,0.0532436829398885,-0.0012664303511055325,0.18125278445161286,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.06051721233666787,0.0010829375388409963,0.5411630668077272,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03673694349572649,0.07060893351029494,0.6032561271612441,-0.10222803624684829,0.17570192323830125,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.022548422615489897,-0.02708949630565542,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0686821764358149,0.05137550980160361,0.18230340843635853,-0.032429628032997204,0.169793980904627,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04167082173895988,-0.009419321841843206,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020281563928293344,0.06263769643072586,0.7463267670096626,-0.1435584041647804,0.10299527630819372,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12075447282330411,0.09282670848271272,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006801799583098352,0.06270032306641031,0.9136883289036009,-0.13020189489123957,0.11659829572504285,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08969492469842869,0.06407729065244279,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05074363638449649,0.06880277182159732,0.4613944913633994,-0.08466664836406473,0.18615392113305773,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.029648351766565596,0.06066314379881602,0.936984237335683,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05111144223894466,0.07347047330443145,0.48718489061569725,-0.0934853152370634,0.19570819971495274,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.13853845413111388,0.24124813865828726,0.9402561783874069,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056988490643020556,0.04795494075609277,0.23564771950796984,-0.03739131428286989,0.15136829556891102,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.019673801192792873,-0.008512038839234286,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06849839834958768,0.07102372519531883,0.33561873803041364,-0.2082797268916855,0.07128293019251014,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1855674383974584,0.12806280616980947,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04095470132904692,0.05319806609246248,0.4420072002943366,-0.06374406424295162,0.14565346690104544,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08156932910383763,0.10115444802274698,0.9329043222378208,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03270860444799777,0.06502430885353536,0.6153272893922652,-0.16068252096790928,0.09526531207191372,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.13380902606343126,0.09585936830080433,0.9560640930990785,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007365436178160741,0.041357925219721876,0.8587752982669259,-0.07403082566334693,0.0887616980196684,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07503443723028018,0.07347714594368439,0.9839047884462332,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004368774698540267,0.046415020622294106,0.9250748637837967,-0.09571787289144608,0.08698032349436553,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05810711953888707,0.04072190554914063,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04083074836506611,0.07939412707070918,0.6074444677526372,-0.11542431330431699,0.19708581003444922,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09375898937457433,0.15313710708503214,0.9535088362706019,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0566482490727974,0.06440475445135757,0.37981512401554507,-0.18340282463020155,0.07010632648460677,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0822471310312079,-0.002615119997004703,0.9191989190351819,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04605707647144838,0.0414716978350129,0.26766555541968023,-0.035563100509308235,0.127677253452205,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.057170084550610845,0.08018170705706565,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04186686963320286,0.04529794192419897,0.35611387628296187,-0.13101745255425545,0.04728371328784973,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07657497011412812,0.007811917279319535,0.9109996615965683,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001714313633755355,0.05584811958724941,0.9755328830659122,-0.10820000487059432,0.11162863213810502,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04397124990232738,0.047444222977736386,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017849470941675872,0.06019575860574805,0.7670402240229786,-0.10062140744961222,0.13632034933296397,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03276630672740157,0.04165819882948334,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11015093362075586,0.11452368528202235,0.33693414671727095,-0.11524238155997595,0.33554424880148764,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.17571741682254724,0.2709150356821759,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061250182226076415,0.06918824779497564,0.37673771486658003,-0.1974191197140103,0.07491875526185746,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08068886698335995,0.05457284334057244,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02482764780316667,0.0623092771517887,0.6905826052242376,-0.09780283260070914,0.1474581282070425,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09583022248573482,0.11543814598937778,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01700515383153038,0.037870056167995166,0.6537350545222108,-0.05752665576545661,0.09153696342851737,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.022511679641732996,-0.024850115878972602,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058198917256836374,0.08146716130439062,0.47555789240102864,-0.10213606951504389,0.21853390402871664,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1375452452975898,0.20483383166803126,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032063334930030635,0.06500202318679434,0.6221936357255997,-0.09586672131507917,0.15999339117514044,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07791497814277212,0.08606563653186122,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07245797732206204,0.0496760333720796,0.1457435018186578,-0.025309098712813963,0.17022505335693805,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05152166580900528,0.14353988004899174,0.7646625175952992,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02494547313970361,0.06814821233510644,0.7145938904639435,-0.10917657736910308,0.1590675236485103,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03406535145021578,0.03276347936744131,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002585171324936019,0.05856541755825789,0.9964810250558775,-0.11552073198257518,0.11500369771758798,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1252193047489725,0.1525937331495071,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09365762014410799,0.047563694575272104,0.04988383386711927,4.782426507812798e-05,0.18726741602313784,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.12363081014134436,-0.035117280478017016,0.5251695931527756,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07818566836655676,0.04765903335857996,0.10196982696422167,-0.015611763147688112,0.17198309988080163,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.11256151299515543,-0.03257514668658961,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04990832181304967,0.0867405326599298,0.5654793983996759,-0.1208051525972359,0.22062179622333522,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11437074318346205,0.16123732958885847,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010586875392478571,0.05372465992684042,0.8439187547140166,-0.11632202684213983,0.09514827605718268,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07542317768371931,0.07800513268595492,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05073805752303397,0.06418832561572939,0.42990071938204333,-0.07559056585999843,0.1770666809060664,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.05029439632140837,-0.011983779889997888,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046865694945304334,0.055552524381358714,0.39956522338545264,-0.06246686456968724,0.1561982544602959,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05625046298926006,0.0617229764756695,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004895342877641791,0.057734228790213726,0.9324854565439258,-0.10873101480010801,0.11852170055539159,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.030157994985565397,0.016192294900672432,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0318467609961243,0.08432164433476426,0.7059403389188554,-0.13410611513863044,0.19779963713087903,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.015693685617535612,-0.02830420480421962,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06071576340575819,0.05997243922091708,0.3121847911029055,-0.05731560156638676,0.17874712837790313,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.11316090516465917,-0.050735247057903436,0.8991737560866705,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025076574758703868,0.08175794391548934,0.759276426493645,-0.135830699366234,0.18598384888364172,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.012951894820951408,0.00803110572712145,0.9672325614747834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09381079958952393,0.05504141882788839,0.089372571374767,-0.014515856432052526,0.2021374556111004,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.13859926227357514,-0.016785151174336148,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016452142143552482,0.07637793546957325,0.8296019159732969,-0.1338667725835961,0.16677105687070107,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.007935321441126086,-0.047790287401111256,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09383448297084815,0.059172951499093886,0.11387091408514084,-0.022623415450475734,0.21029238139217205,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.1146178568872687,-0.0031760362630177796,0.7095033877612622,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007182110502767851,0.042959552794143825,0.9866727196000109,-0.08526662563464162,0.08383020353408806,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06532355695100536,0.028257266361400517,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04885050873715352,0.05969359588007881,0.41381997373793755,-0.16633308395587026,0.06863206648156324,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.025030024688935705,-0.05674340673997845,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0030834401443473264,0.04904254948248532,0.949910700141094,-0.09960376068373236,0.0934368803950377,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.049422556456585096,0.023672891689221383,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0413181002382036,0.05581560667261583,0.45973457768215353,-0.06853222981172807,0.15116843028813526,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06276656995634697,0.07603926062078596,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12181358373019181,0.05582415084811842,0.02989675515261993,0.011946437944394928,0.2316807295159887,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03685108617358471,0.13798334129133769,0.4120146569470434,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00303471865556986,0.07685360479861672,0.9685290058753802,-0.1482203577637115,0.15428979507485124,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10473088961915869,0.11811646341078513,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04883220778530211,0.04316019509264848,0.25880450843732405,-0.03611108959308109,0.1337755051636853,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04847855572421686,-0.043454133179493586,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024669575657968092,0.053601579140842646,0.6456855282204351,-0.0808233413026198,0.13016249261855597,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07433910254251509,0.10498265869969428,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04463072424662428,0.05854488899555792,0.4464742910160441,-0.07059108847361448,0.15985253696686302,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03758265769480309,0.042947960948211475,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0717353493031269,0.06683726704635326,0.2840269867831216,-0.05980663836605839,0.2032773369723122,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08489699628354058,0.1682508798783813,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0446805083751228,0.05232115207374417,0.393821213984465,-0.05829240845806988,0.14765342520831548,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0643461783616228,0.08672991611712753,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047055292611344474,0.07066469856111834,0.5060019113192276,-0.09201943796264439,0.18613002318533334,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08078845468781973,0.11165936350882398,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13313209209103044,0.05587293777957119,0.01782069960992788,0.023168929064864827,0.24309525511719604,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.04847756248895636,0.07023037635182822,0.303536876132493,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019227341276375305,0.08370495584795101,0.9816895403614525,-0.16666190968914982,0.16281644143387478,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1637144693990352,0.15966248088736376,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06052499538319461,0.07154535715116131,0.39826162253685826,-0.08028295359590729,0.2013329443622965,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.011613332604276818,0.07358791551451908,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08746272046917372,0.14013905194580034,0.533038453202645,-0.36326947106897367,0.18834403013062626,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.15978172707326718,0.10131276092684012,0.9463787165114282,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0629568358584482,0.07244339022603065,0.3855317944224199,-0.07961852613559724,0.20553219785249366,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0229777611811189,0.02574229461397107,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009578315488350865,0.07451282650538667,0.8978051953574349,-0.15622652147454255,0.13706989049784082,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11058837390401045,0.13855124703634378,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03443788256753079,0.0677313562169225,0.6115216995390137,-0.09886375614436703,0.1677395212794286,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0235262913163584,0.022140142726437637,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07056692412706693,0.05072265219688743,0.16521086290547726,-0.029259995564368646,0.1703938438185025,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.13589328074280266,-0.056551854510154084,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10730135956973848,0.08032990468747374,0.18266482144361648,-0.26539811903984367,0.0507953999003667,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.14614335923474434,-0.062238960443255595,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040399869158534545,0.04892103765061892,0.40957929514807345,-0.05588130474013065,0.13668104305719975,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.024496811001829846,0.054950029346311074,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04233174274441667,0.065645076739267,0.5195238878449597,-0.1715273884758728,0.08686390298703944,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.16002336380114335,0.1445595493922054,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059170577674544575,0.038219797727149334,0.12266183019844908,-0.016049555995145043,0.1343907113442342,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.051304916455638776,-0.012829452657697712,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03101670619973881,0.06959962342729914,0.6561829881066616,-0.1059618569767645,0.16799526937624212,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.015788693076688766,0.01781521603155844,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055741762925945695,0.06121432297154541,0.36325467439057024,-0.06473374532480487,0.17621727117669628,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.059489295313689836,0.11537359619650253,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05273976020132152,0.08043863402872788,0.512562469472124,-0.10557098877342053,0.21105050917606355,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03995895319046255,0.06429343188574553,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06419555468359124,0.05048774208826141,0.2045564637473611,-0.03516903996108829,0.1635601493282708,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.025785288190073977,0.08298515243696206,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010054701453502386,0.059353290841162205,0.8655955547639766,-0.12686752455321218,0.1067581216462074,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.028166691330453433,-0.01846137903746845,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015550029930714025,0.06174699701661153,0.8013454660561493,-0.13707389048197366,0.1059738306205456,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07757236068186368,0.03159532095809481,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07672888789741937,0.08388077600424208,0.361081639461065,-0.08835631816253918,0.2418140939573779,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.12131869739450987,0.2068864260643671,0.9134053709502656,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015388475360518399,0.06273861605500163,0.8064119895190295,-0.10808698412775306,0.13886393484878987,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06695209824830489,0.07029055979333393,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04074481847393324,0.044354799173683,0.35905451552174317,-0.04654957137488297,0.12803920832274945,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.013808789571406337,0.03487695923108485,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06774787158960219,0.07667725275431289,0.377665778353637,-0.08316012752591748,0.21865587070512185,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09963472010313548,0.18259568492665607,0.9170727894069044,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061240181247076315,0.07246159159695131,0.39872233231151577,-0.08137100274590797,0.2038513652400606,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03761736794634261,0.08119943881230633,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09086521036647514,0.045615872855240165,0.047302850340571925,0.0010889096616348154,0.18064151107131549,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.03559066977102271,0.04578459213178385,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014854910069654897,0.09608354286640569,0.8772398761164495,-0.1742464815563508,0.2039563016956606,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.11708498248797329,0.12315064478879048,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08391702830511784,0.09537146210240027,0.3796364078071479,-0.10378292183146694,0.27161697844170263,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.00969639969719528,0.10537540342336163,0.9190466011506984,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0047025184301177445,0.05835526749317978,0.9358275662014057,-0.11014610145280258,0.11955113831303808,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.043026925799663454,0.028941525326593425,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04977516453598915,0.08391914230440464,0.5535500749198413,-0.115385549988123,0.2149358790601013,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.029757150519666622,0.08612043091555353,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011061568417077226,0.07362993533007113,0.8806849891785358,-0.1559721620616984,0.13384902522754394,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1301814676222996,0.1297422490425837,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1155822907561095,0.04048649074907648,0.0046132939431071645,0.03590109339072173,0.19526348812149727,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.03150439995373773,0.07898134689612582,0.12288700443082104,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.30459993299478016,0.22852398284743547,0.18359968338302665,-0.14515662142840985,0.7543564874179702,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.02040603068324071,0.21906159835934835,0.802983078068576,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01620716829498196,0.07568834516192839,0.8305943854537288,-0.1651689048526207,0.1327545682626568,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10729655986729102,0.08286885737868123,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0036957755671325385,0.08214660259964439,0.9641459270300466,-0.15797641516941946,0.16536796630368455,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1077837604086253,0.08730625835293883,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06840194085981013,0.07175511954431824,0.34123947679980904,-0.07281884011188311,0.20962272183150338,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.05440021547640953,-0.024647535690491867,0.9043732915535342,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006667146637960407,0.06277023901376362,0.9154843810376608,-0.13020484306432584,0.11687054978840503,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07335110228759417,0.04807523072137677,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041562808470479766,0.042192300311297455,0.3253973153334305,-0.04147558152583999,0.12460119846679951,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.006249501778486664,0.016113764127729458,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05509844076961622,0.06765310333025437,0.41606242544667926,-0.07804918894837645,0.1882460704876089,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.03303053124033859,-0.0188064610388317,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03459281035209503,0.048987154000544736,0.48064923029633544,-0.13100410740616455,0.06181848670197449,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08658279869397201,0.07138266403409238,0.9390961972850291,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03196613245173258,0.07914217988340527,0.6865752634811064,-0.18772533851136083,0.12379307360789568,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.10198422079979604,0.027000872898964697,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0016793964653891492,0.0649030424108974,0.9793742828818742,-0.12941464929351465,0.12605585636273636,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0879986373394563,0.06315289184771783,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.076874817079317,0.061820269379106174,0.21466985765715088,-0.044793250328831,0.198542884487465,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0393208903769657,0.026256617846315562,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09894451997640964,0.07111773634713553,0.1651967111226328,-0.04102183129805785,0.23891087125087712,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1012488518090003,0.19723909330127457,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04903694925309418,0.050121036530896584,0.3286981662191487,-0.049605934585072994,0.14767983309126137,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.00374820562551992,0.03783422852926334,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04153296372603525,0.06913741172558054,0.5484837892504457,-0.09453592362656198,0.17760185107863247,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.07065025675411765,0.08236193270072659,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028943997440808486,0.1009519675146555,0.7745365697851954,-0.16973890886030052,0.22762690374191752,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.04939004933647199,0.08811220095296872,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013622394387693472,0.058550070374611816,0.8161860785693287,-0.12885440454612407,0.10160961577073713,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06528174798648166,0.028387812898660342,0.977947781515814,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05214262475638763,0.09231644881141089,0.5726250747600192,-0.12954477372433992,0.23383002323711521,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.13152492360371573,-0.042201031084930014,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06879997221700378,0.08571877066474845,0.422842441750674,-0.09990257910036456,0.23750252353437212,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.1653966119852091,0.21844277962493344,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042009359600776085,0.06483876427597465,0.5175537658763516,-0.16961810705240943,0.08559938785085724,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05982391434901547,-0.013423718899980182,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010543231451999762,0.05625079950453408,0.851451222284215,-0.12125006166508451,0.100163598761085,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03961137644395968,-0.004704828807662508,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0541021564192171,0.05404694457714082,0.31764236394347684,-0.16047159417903495,0.05226728134060076,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06114461446619999,-0.05317131608139788,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04532869528065177,0.06120115382098795,0.45949820107354145,-0.07512089485110927,0.1657782854124128,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.012552462206511118,0.024540383258455447,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0034320653832144187,0.07846974398794526,0.9651434899843554,-0.1578678547596385,0.15100372399320966,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.053141874770841355,-0.011813807203641878,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020377129839519816,0.058217553011947504,0.7265774524458609,-0.1349547147535872,0.09420045507454758,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.039379333919174565,-0.00939033726750547,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04490006979162122,0.0458657287464881,0.3284142756655386,-0.135168110240141,0.045367970656898564,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.06523051270822479,-0.029396671617931486,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00031355564657030335,0.07219206731986229,0.9965374721034671,-0.14176717938133582,0.1423942906744764,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.061241373228635744,0.03802807183587522,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01260341512070361,0.03251717424776596,0.6985989789510679,-0.051393422616092505,0.07660025285749972,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.046033526131856864,0.031683816914432096,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007465454755553016,0.07150399321652023,0.916918495218694,-0.1481919956457106,0.13326108613460455,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.08320520037049497,0.04374771521860859,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03171921464931186,0.03305674294077774,0.33807870582264754,-0.09677797399809743,0.03333954469947372,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.015255502174636143,-0.04321573915373449,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007561923575036484,0.043010040184798544,0.8605586631649376,-0.09220970206239194,0.07708585491231897,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03661226151037753,0.0035470063064485333,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10348823900811158,0.1140712985760642,0.36503378200242853,-0.3279912148747661,0.12101473685854294,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.09746295049829858,-0.10532979823515347,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008333703156295839,0.06514015334089263,0.8982882040388027,-0.11986820614071297,0.13653561245330464,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.0033089353628299525,-0.021246940647650106,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05368821077998036,0.05163718698280504,0.29932725793825476,-0.047938598835870955,0.15531502039583167,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05602753798563901,0.0820973889504646,0.8866736552767163,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005402656587691472,0.0827812117215696,0.9480080845923895,-0.1683238173821177,0.15751850420673474,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.05560892124486473,0.025748831346575383,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010651807592057137,0.03630575676316966,0.7694304685327529,-0.060801314588256106,0.08210492977237038,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.03704727054339717,0.013469397575571869,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027832193281451253,0.06858155090895274,0.685166476001775,-0.16280709460024,0.1071427080373375,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.033422266207223876,-0.015250665280371568,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01239614893541712,0.0435873702568615,0.7763064911207183,-0.09818016695763696,0.07338786908680273,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,0.0823098582152902,0.06211283946452015,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05809307926080322,0.07287678542754147,0.4260145874194011,-0.08533524499176014,0.20152140351336656,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.006111798834572769,0.0069885650611334026,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:4683,TP53,NBN,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02960836366206889,0.05073968316775416,0.5599823430047758,-0.07025207457162233,0.1294688018957601,289,9,298,3,log_other_mut_burden|lin_Lymphoid|lin_Uterus,False,293,-0.02926032981923946,-0.013856325554887805,0.9506287080350535,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15031179117460425,0.15169566408978372,0.32559694404511297,-0.453547102947545,0.15292352059833653,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.061637892434934685,-0.012466688130476111,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15309288445158256,0.2332295990377845,0.5139930362568987,-0.6193122098572292,0.31312644095406417,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0613678576026273,0.033323197804528845,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16928553585423406,0.14118471703306879,0.23507665640951794,-0.45150976384375585,0.11293869213528773,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.021417452481400735,-0.04445365768025304,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10532325487495292,0.28067682782137526,0.7087571614958156,-0.6663882391811637,0.45574172943125796,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010724137636336211,0.16920496138859747,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12336716427046582,0.15769771561287316,0.4370150407631811,-0.43860040608182915,0.19186607754089754,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04787095545752627,0.026274526891370616,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13102709545156507,0.09389924160023655,0.16787303738205833,-0.31872900488147365,0.05667481397834351,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02059762312369495,-0.05082648747357175,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19052089530907074,0.16713360986177977,0.25869949176196416,-0.5246162209617375,0.14357443034359602,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04504000969550276,0.0014525034686254878,0.8664830381179188,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11465602669182319,0.11245917191184177,0.31191113925281744,-0.33945870817275503,0.11014665478910866,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05469510104989216,-0.00953810451814227,0.8990379896110621,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11036438566829417,0.14917657198000794,0.46219911960829774,-0.40856410406500965,0.18783533272842134,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0060699273214421855,-0.04963949784272701,0.9372011503139762,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16161444414851087,0.2475843666967121,0.5163208963000215,-0.6565285412379858,0.333299652940964,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.033483873835531246,0.0756606503802274,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11365235469922835,0.16303512264576026,0.4883437616302859,-0.4395549211441467,0.21225021174568998,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07234387683166953,0.10919552435147532,0.9404802865694325,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13855308730116356,0.26020939929964376,0.5963053516388116,-0.6587042649655166,0.3815980903631895,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.042389996451177796,0.0666374169130916,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10449834645600081,0.2035334741723986,0.6094817214660684,-0.5113559640894745,0.3023592711774728,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.025544987267754872,0.0666804706672754,0.9548186116040361,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08951617865643219,0.14730058853064693,0.5455988051937313,-0.38396585957144896,0.2049335022585846,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.011076282914904511,0.02756284846855426,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3042958934628656,0.19166322671732047,0.11745066417651907,-0.6874252245335001,0.07883343760776884,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12615043645881616,-0.19567541835940055,0.7176009922554474,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2504171511408201,0.15109109813540503,0.10249243292406324,-0.5524439527907897,0.05160965050914956,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08957631023381694,-0.35695131445890055,0.6839484127328216,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13282460965022552,0.12698163889578104,0.2996154382152517,-0.3866572889891096,0.12100806968865857,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06092570623347941,-0.08214404764147477,0.887112028553774,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09400026074775648,0.18774051634695818,0.6183604345452851,-0.4692882055184653,0.28128768402295234,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08071021021813818,0.12545904239370248,0.9572656024379023,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08898191642382007,0.17023486246193298,0.6030453270681294,-0.4292765576913188,0.2513127248436786,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02863920980282399,0.03633437329470858,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04747345631527538,0.1673365639174995,0.777585199139124,-0.3819744813445923,0.2870275687140415,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04204152251015651,0.12234313775832754,0.9700679690002965,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1812481097517472,0.2408166151597955,0.454514765706452,-0.6626336642845669,0.3001374447810725,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09337065748184634,-0.02978238869323162,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.125035753258967,0.1948114465988251,0.5233498077969507,-0.5144582862020874,0.2643867796841535,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017041775254068053,0.09552066213930865,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02080951079942935,0.09933194284957872,0.8347489620546439,-0.1777522136884659,0.2193712352873246,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09154969458246298,-0.047296263360098297,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03154470425237737,0.2479248357073829,0.8991662091731312,-0.5271393891966157,0.464049980691861,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03781340106584676,0.13315769381643522,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07094364418996205,0.17639693923334449,0.688933407844579,-0.42355610140928535,0.2816688130293613,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01956342550114624,0.0370709616753463,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1088261653484627,0.14920413948029373,0.46851727634672324,-0.40708099039304524,0.18942865969611986,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1273780414398217,0.12957018780694685,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09267625313125515,0.15160887386428465,0.5432456794583573,-0.3957380737154664,0.21038556745295606,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09555157390828475,-0.03284863364627266,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08679091901328212,0.12343698725768125,0.48461341457393015,-0.33353794068979903,0.1599561026632348,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.23179816367618422,0.18276341730736437,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09797438801436052,0.14874728942921195,0.5125506872827621,-0.3953159828192754,0.1993672067905543,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04480773721347267,0.017044566046403097,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022700247598425493,0.1226389894364684,0.8537562474388162,-0.26785209435968327,0.22245159916283228,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12289657585735073,0.13023482914420897,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14996241644917868,0.14302329572994546,0.29847049176126556,-0.4358619108855813,0.13593707798722393,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02999653754368315,0.014008612694845279,0.8856954470736713,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14360223471062727,0.16205282949152805,0.37896388819137883,-0.46754122511885854,0.180336755697604,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1243709378551329,-0.05112484923098977,0.9183506089424412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08303685333842664,0.23432800506876114,0.7242703070949439,-0.5514518611141334,0.3853781544372801,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05250012467754903,0.041604515821230426,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1356805034765614,0.1700254452637272,0.4279157879318988,-0.47555652572966983,0.204195518776547,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0012560495818535124,-0.024468614575686765,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008276591487155089,0.28961309000679497,0.9772928715107537,-0.5872049093707624,0.5706517263964522,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11059179449015968,0.05134325100913496,0.9982821339400993,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10431670484742403,0.11316197972577499,0.36018784187688235,-0.33052427913035687,0.12189086943550884,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2957103713776532,0.07100898877466215,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09538921321433078,0.23387889623512634,0.6847834684590697,-0.5629064652235534,0.37212803879489187,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0033710642749800223,-0.04920278891748399,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0402666290005238,0.15311683672143495,0.7934381367689669,-0.34634282438492275,0.26580956638387515,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.4590573672519115,0.14449396565581338,0.9732342286065081,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11761645751399027,0.10963146537618865,0.28750329640033073,-0.33676663417162245,0.10153371914364187,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05594972916763291,-0.0720765680377886,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05647377146493206,0.10200896899797168,0.5818329534109208,-0.2603867949738184,0.1474392520439543,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02253531125210583,0.03965077450042433,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11376407531321592,0.1070011973699523,0.2918131739124074,-0.32765642114421745,0.10012827051778558,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05622523002727782,-0.06160140204732063,0.8799526010712531,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07507268843789684,0.14224372600205482,0.5995393082615863,-0.3594138451927046,0.20926846831691093,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0032336619426973144,0.03325382304895656,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10931080726614456,0.1368295343902797,0.4274079863567657,-0.3828291492012528,0.1642075346689637,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004243484572203527,-0.05984819445238297,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035437799406607295,0.13285294159944175,0.790551046882513,-0.30100704561799024,0.23013144680477565,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.001993006238585174,0.08518258171816952,0.972929334907502,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03953143862357865,0.10871815728434159,0.7173832728096308,-0.2568559384193324,0.17779306117217514,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.048808967815108545,0.04218580926338283,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1982676548594025,0.14133407128989792,0.16565553827979979,-0.48079043775427344,0.08425512803546842,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02020916422587805,-0.10496219158361222,0.782722418372054,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022401346480963428,0.16188770574952951,0.8903918526825667,-0.34601025923215367,0.3012075662702268,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.040983944500535795,0.023495217475652048,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15113945082833147,0.10745468750308623,0.16455618313250242,-0.3659383105187234,0.06365940886206045,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.017790923781745648,-0.10620781431100026,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04420365831764849,0.09259289782660662,0.6347574619323066,-0.22929422375261696,0.14088690711731996,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.030723905428380764,-0.05370538418044792,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18190059190983526,0.14386983985218976,0.21083998745227836,-0.46949230393451624,0.10569112011484572,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00918507368282488,-0.033675636990404025,0.8252886794984905,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09784681836375458,0.04169304238160246,0.022142843722990344,-0.1811900225430434,-0.014503614184465774,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2597122309316758,-0.1858932466948276,0.34668618042031035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13298188066621972,0.10344993613137493,0.20340871405053257,-0.3397753564317604,0.07381159509932095,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.28466171327047474,0.10498726011794139,0.8179445630780711,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2167225535836207,0.22415474234665603,0.33737867985030323,-0.6648014989425418,0.23135639177530043,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1354192184161362,-0.08397593967807679,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12250022939817239,0.18376261031294772,0.5074867067763915,-0.4898364533094591,0.24483599451311427,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.25379839698871476,0.12786145607157479,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1925698686832699,0.17871509487946247,0.285420765584993,-0.5498162530112332,0.1646765156446934,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07660137379146677,-0.0247936873560994,0.8771632762317894,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019823794756336065,0.20267041972883024,0.9223963434728493,-0.3853086016267953,0.4249561911394674,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01951446816003333,0.20106332233010388,0.9911128933864998,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21382884072577255,0.17276068796471172,0.22048781943217147,-0.5591725352303225,0.1315148537787774,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07044068121734988,-0.12203181651077755,0.8354330838437122,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1054080174673301,0.2568768996621903,0.6829678761607648,-0.6188976232758896,0.40808158834122943,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12920783384746273,0.20269306809812065,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08793945134417251,0.1815019200713351,0.6297314424331069,-0.45075661985364024,0.2748777171652952,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06143043518030335,-0.0014245926264877362,0.96007126858481,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13837648968757424,0.16245496065278817,0.397612324822309,-0.463119328833276,0.18636634945812755,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.023225636805521196,0.010432345881706977,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.125221157744414,0.09388100146533943,0.187139320929639,-0.3128866056641964,0.0624442901753684,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02661057188721463,-0.08192586145652887,0.8085168201280608,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11246679316302925,0.15658163138107012,0.47529318516001573,-0.42546901438440826,0.20053542805834973,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1025907347625909,-0.057487547414140486,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09332683987113773,0.16410439337908064,0.5716113046250341,-0.42136684805596086,0.23471316831368544,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07355467601774329,-0.01704959507273397,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1593748278790156,0.18629144298330588,0.3955611190884326,-0.5317661162696917,0.21301646051166048,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.018091069742467717,0.03484339314041156,0.920957044807631,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2550494470722793,0.11544791260792435,0.0308630643167776,-0.48582653607647874,-0.024272358068079813,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0032656817740679494,-0.15303794097422843,0.42002168600416523,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01146473677276121,0.13965100882768866,0.9348351350625819,-0.2906231257442878,0.26769365219876534,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008978680207842822,0.05714245720585629,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15139251033853052,0.14192520921653934,0.2902406967480898,-0.4350969611113958,0.13231194043433475,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028228986020699252,-0.08615646516969111,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10667986223243496,0.11893543566563305,0.3732120885086997,-0.34442841049399125,0.13106868602912136,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.16724580620968368,0.08476630376909432,0.9157828620037275,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14953509072823207,0.10379947710140237,0.15472464870176691,-0.35702728893689384,0.057957107480429676,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.014213240825944653,-0.05448340355616142,0.7731429757303867,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08060708764627145,0.0970835091839857,0.4095628346572605,-0.2746742572787073,0.11346008198616439,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02741855674892935,-0.0104071627721811,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06419307884999106,0.13431041623906873,0.63436976940549,-0.3326757753527868,0.20428961765280465,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08527248917200851,0.06882235847128969,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06849279063054672,0.14144621053954834,0.6299273645420801,-0.3512397366914103,0.21425415543031687,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0897041177175909,0.05289341295829604,0.96007126858481,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19048915467763047,0.09769568943686781,0.05572327085219434,-0.38578005519886793,0.004801745843606986,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.009719061477801647,-0.07723602150216627,0.5511199060187707,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10014467413494782,0.30797160866936224,0.7461433981413244,-0.7157711479199529,0.5154817996500571,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06871167069213108,0.144927458752914,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09600457478459175,0.08248774357620417,0.24893822119096248,-0.26089522469777693,0.06888607512859345,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00568158161102086,-0.061601335206915096,0.8577318021260126,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10025282138082792,0.21057999614098907,0.6356911185884508,-0.5211962357236639,0.320690592962008,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.031946438689249075,0.05947118858408719,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15639809812470934,0.11232540756441418,0.16878546800360675,-0.3809333884851389,0.06813719223572023,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007081200625616371,-0.0838442627049901,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07735991451252494,0.1397263379272487,0.5818075674941867,-0.35666888420847576,0.20194905518342587,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04543776993215869,0.037346382471725614,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11197294497286553,0.13690090567639662,0.41653955421157285,-0.38563395607605555,0.1616880661303245,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05260977052610782,-0.031624452966914005,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11626521131717747,0.11364407078251092,0.31025268877013756,-0.34343647189114196,0.11090604925678703,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01272923377491759,-0.04809861305851582,0.897405574514287,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00467921407542826,0.17445640653129543,0.978688106712247,-0.3534126016954837,0.3440541735446272,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019548286523057724,0.1419782002111411,0.9984157213799838,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013211698375807468,0.13297121106052384,0.921174920618639,-0.2525939651196134,0.2790173618712284,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09438902487254906,-0.03018598357002266,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12603327886517524,0.1412834104352442,0.3758099472593397,-0.4084547921545648,0.15638823442421435,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.009388990791976281,-0.016511378445566605,0.9164018869766861,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07566725692513945,0.07622607296815556,0.3247297557206089,-0.2280410056437904,0.0767064917935115,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04195063025402943,-0.05540793281401485,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06660125533746004,0.13652928964906808,0.6274003941975026,-0.33951941658674717,0.2063169059118271,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022220742020647055,0.060149765945109145,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07352347895253357,0.13479431155508595,0.5874015211730388,-0.3429734684092736,0.19592651050420645,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11748547489932114,0.05072359778655945,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2614204110409426,0.2120153374698181,0.22222080572302996,-0.6852330318173285,0.16239220973544338,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07774955510238543,-0.19925687798237818,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13970411662250157,0.1258103064366278,0.2710998997640801,-0.3911953357385617,0.11178710249355853,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.053789781491429885,0.06750683547620334,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04819935121159904,0.21938326401655914,0.8268235534981425,-0.4867402472945145,0.39034154487131645,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04179766087994491,0.10598297782342891,0.9807718720364996,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14687887064849686,0.08216444151976898,0.07872454498231994,-0.31112324895946974,0.01736550766247605,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03247481170671132,-0.1101676663130032,0.6337247675321748,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1524722578370236,0.18619850410117067,0.41599740023677867,-0.5246777640494865,0.2197332483754393,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07189659878687858,-0.01868029370063069,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1318658547926986,0.14724956632714462,0.37396956570218653,-0.4262135437761779,0.16248183419078074,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0012941942894647688,-0.009577933717769382,0.915842680969123,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06903400784064681,0.16071866789184852,0.6690243044607479,-0.390306047211999,0.25223803153070534,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.005087178786000146,0.1175674782760922,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01879164293460539,0.12638306666800145,0.8822824079144826,-0.27142779343927087,0.2338445075700601,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09514516313728309,0.06829176042254076,0.9870366109823806,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06437228812737844,0.20555830807507341,0.7552114579163842,-0.47527749105902256,0.3465329148042657,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019952462656871513,0.14756559340194347,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016913107952520292,0.10273152256598017,0.8697676012418991,-0.22227049546338645,0.18844427955834586,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21507299252650364,0.12684408464636773,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12677442935623215,0.10495049894240166,0.2316559550226079,-0.3365674874405348,0.0830186287280705,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.045920164872602906,0.003109601663553646,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08277550610620105,0.201962647874256,0.6833246572588333,-0.4864930867114806,0.3209420744990785,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04181095608743475,0.07641818423014542,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10029623482043684,0.17123754281067244,0.5601937869065801,-0.4425952055457548,0.24200273590488117,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.027472441219192182,0.0512654627726428,0.950784323383458,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04107629489564232,0.12541337571959935,0.7443725400173964,-0.2917740608141269,0.20962147102284226,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08060890762078403,0.053359067017270376,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05731650509039058,0.09263628305868302,0.5383633681083206,-0.24249379636853963,0.12786078618775848,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07255023999087043,0.01931871272400005,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19407543810510747,0.08479287620936206,0.025509330970968306,-0.3635739824949594,-0.02457689371525551,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022397144530138767,-0.14124809289429255,0.3742940281840044,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011724026949687313,0.07149978732008892,0.8702858604239787,-0.1546500652764894,0.1312020113771148,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006205569140477348,-0.003779979837581782,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.22263269757029885,0.10806863568855649,0.043592076411757524,-0.43865882219638014,-0.00660657294421757,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1243390087646769,-0.15602208627238173,0.499126055229397,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01523271228761373,0.10619460714762805,0.8864067142062707,-0.2275127072382714,0.19704728266304397,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.012249278527238118,0.04031047691603432,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11167411746364148,0.12182635012419643,0.36286943828970697,-0.35520152138604594,0.13185328645876299,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04524786353830159,-0.005744507410299538,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03923498204073941,0.09293635874549638,0.6743610298178351,-0.22501211606978264,0.1465421519883038,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0306695716775987,-0.036116529038009326,0.9604862397331528,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.22755927880876756,0.13761508469265044,0.10326538109598299,-0.5026479134235119,0.04752935580597675,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07889033248014064,-0.11020104496021683,0.6839484127328216,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025785834320539415,0.09459456075927691,0.7860717794178492,-0.2148776669446173,0.16330599830353848,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07054795949626691,-0.05831194621075445,0.9723917383541977,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09629256326386958,0.06838876872481107,0.16412055679390777,-0.23299976402975003,0.040414637502010894,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06916084522626276,-0.08809845714494118,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11131379137406222,0.10188747042947553,0.2788329938872626,-0.3149839427051644,0.09235635995703997,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.044725056367260034,-0.031109189461153985,0.8741612580873186,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08095062324285848,0.14579168471749804,0.5807225850271944,-0.3723840484134475,0.21048280192773058,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.005774538379914176,0.020799347407807124,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14237204949432386,0.1504243142035285,0.34758338413333567,-0.44306596905645684,0.15832187006780912,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05276449264810398,0.05995817186080492,0.9086350165348037,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.084935814880537,0.2050058612877296,0.680077598334485,-0.3248650626585302,0.4947366924196043,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04027836142967617,0.1968286836562423,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1012495144670629,0.081552249499233,0.21908676480321837,-0.2642701383660293,0.061771109431903476,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028865620303942158,-0.06965930923523556,0.8337844604918982,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05128409498189452,0.13832468920141056,0.7120863351135629,-0.32779120879800877,0.22522301883421975,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03241391608187196,0.06810579385891291,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05458760241465417,0.12212070423915149,0.6564347784549012,-0.29870341182877536,0.18952820699946704,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.041538909851369946,0.07041183222423582,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05225098527904357,0.17951056927326176,0.7719657332817997,-0.41108750026274105,0.30658552970465386,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.001826804041778725,0.09195357488359238,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11200306404436676,0.14148833232219682,0.43160840234119047,-0.39483421034899135,0.1708280822602578,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.045088424952508366,-0.01770057876557718,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02162239773487494,0.18349226287584464,0.9065767928905127,-0.3884182048196896,0.3451734093499397,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0157276192371206,0.03290931688297358,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06872017001331561,0.07435313003273133,0.3589444120149716,-0.21734995915102462,0.07990961912439341,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013975255948403471,0.02910957065960359,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08217448779844204,0.25759089391042367,0.7507900153783662,-0.5970913477725457,0.4327423721756616,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03789905970972045,0.1010005893053019,0.9646550643928868,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013268795458266926,0.15490767928269708,0.9320157743444142,-0.29638724319758614,0.32292483411412,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.14405104152290432,0.1626833743176483,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05569447011862234,0.2026219705168018,0.7843308839383111,-0.46073001790688617,0.3493410776696415,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10641088754701532,0.05372376997895205,0.9719042392604298,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10689994634080086,0.1461607397291091,0.4672986676211309,-0.39907110196781886,0.18527120928621715,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07338687551732771,0.03600452433398708,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05992481117190123,0.17685412935655717,0.7358770671857904,-0.4134511784253957,0.2936015560815932,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05772528354067816,0.13290988783690513,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04277154742374474,0.14873265449966516,0.7746323884900042,-0.34008388742134177,0.2545407925738523,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01789739169037018,0.05132730355126205,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06556181852728145,0.08940125424063272,0.46611293876353777,-0.2442723793413658,0.11314874228680293,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09239972034968637,-0.05227567024008387,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041896523654872946,0.11173617536257541,0.7089703055789676,-0.2652539556269079,0.18146090831716202,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07441772116669164,-0.06825630992695397,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07384292345334478,0.10305146670342887,0.47633407922103976,-0.2798398701820127,0.1321540232753231,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027290726790321032,0.015626353582154473,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07520332891918671,0.24346363830708434,0.7584412822860357,-0.5618802073283649,0.4114735494899915,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03673061616789965,0.20694463641077943,0.9669418369722411,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09825554815712928,0.057289163830371324,0.0913248782745838,-0.2127749548887004,0.016263858574441847,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1054496227698355,-0.16426708886194166,0.6648373299485711,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02544130569101813,0.10429944018205174,0.808093792599857,-0.23393291585746623,0.18305030447542997,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.045858903558661755,0.009828845104853202,0.974516576191754,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1033675603740902,0.14451897081857584,0.4771379171059503,-0.39225686671140136,0.18552174596322094,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06565177233341651,0.05388272364874612,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08383918114374156,0.1107716887031444,0.4519976020458969,-0.3052686317550153,0.13759026946753217,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026216793687125404,-0.028791679528507346,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12428635584118619,0.1485185452836684,0.40589617032912384,-0.42117069761447135,0.17259798593209896,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11640453778521673,0.03943086634648825,0.9237532919369174,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08436162253133682,0.08348074191107652,0.31615860805007,-0.2512372478323934,0.08251400276971975,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0016473377353009098,-0.0268802749016862,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09507923942038884,0.12955141856470434,0.46576924979704437,-0.35404883512250207,0.1638903562817244,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.037522108635689604,-0.012574725722157126,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12598643149135016,0.2310637454805082,0.5875410015666838,-0.5878762773259362,0.3359034143432358,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017607519437938614,0.09335538589112262,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09261408624591091,0.17629156628660667,0.6012164289014019,-0.44501590594603946,0.2597877334542177,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.020659272950951723,0.005635095779781979,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11985137236420886,0.10895073993169722,0.2755628313799674,-0.33764079824738275,0.09793805351896505,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02674757986716093,-0.055502810402613845,0.8716406527156833,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17832941063840008,0.23945460602221427,0.459247671545705,-0.6569923476992557,0.3003335264224556,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06151927104625425,0.038780069636653536,0.9366557334939974,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03294210660856801,0.13169179618073057,0.8033018736018883,-0.29619025620081346,0.23030604298367746,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02415228531182194,0.09336886731617325,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17411184586262426,0.1635209004013288,0.2911101080596605,-0.5009854682045325,0.152761776479284,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04309628280925369,-0.054685120931346566,0.8793120387281526,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024881011657025665,0.19429964169547134,0.8985200264710274,-0.3635184378620126,0.41328046117606393,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11210097187489518,0.1646312567809207,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010941900431990219,0.18542706140780477,0.9531345759986911,-0.38160531467339115,0.3597215138094107,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2577497450226847,0.001731030537538425,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16774413507746738,0.16632207110538572,0.31711044423525964,-0.5002172178711337,0.16472894771619895,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0913199458127513,-0.12841545702900592,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04464316088826174,0.19334460358788588,0.8181531880706876,-0.4311335164325552,0.3418471946560317,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05814262879502784,0.11849486864210712,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07009509714824132,0.20219935937853034,0.7300181177339005,-0.4742858573083194,0.3340956630118368,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.011565179317347577,0.08573304373698598,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07715137679858132,0.1056506922753942,0.4679880265146139,-0.2883441014119527,0.1340413478147901,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10173078510998877,-0.020194756830571335,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21359710761840722,0.30793298887404236,0.49049365444102966,-0.8291463815325741,0.4019521662957597,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7636580954504453,0.24242192542172872,0.9418332435783486,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021226994097726156,0.15201210503481388,0.8893969437904465,-0.32509486230660534,0.282640874111153,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10221608804516406,0.14091866138567957,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037801021504846065,0.1314248768498634,0.7745933704688875,-0.3005156069573424,0.2249135639476503,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10474465668493116,0.08972966803080526,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15157496283220465,0.10336725530259147,0.14760059834865477,-0.35820316197600244,0.05505323631159317,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10701993063233699,-0.12113429755854103,0.7662201971017615,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07131123753151077,0.12809495744382082,0.5797323056995008,-0.3273694089373113,0.1847469338742898,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03714225299139471,0.07124055770213651,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09901722383530911,0.11177560429634757,0.3791175290380927,-0.3224534731229016,0.12441902545228342,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1532811826163582,-0.09001672969893786,0.9183506089424412,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15332745783992152,0.11063805459809728,0.17075824969736936,-0.3744897776815018,0.06783486200165878,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10963856634288671,-0.12133251075735188,0.7844207095472905,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10054977461793993,0.13984533695715332,0.47483791141007614,-0.3800966199852247,0.17899707074934482,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023974795523529168,0.04727832925415321,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02524813904210767,0.10439949136981964,0.809701038844112,-0.23393974868314918,0.18344347059893382,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05521983707962424,-0.06663320267691328,0.9747331744048557,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0789216168581652,0.15662603645742246,0.616127571390129,-0.39201260256238424,0.23416936884605385,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.041397278196287246,0.07101092838954534,0.9561721723743585,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2059731360671691,0.1477536411321947,0.16828450225762057,-0.5013284562283977,0.08938218409405951,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05667117376033574,-0.13784104774174252,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1459106685891797,0.23652394545795813,0.5395621988678905,-0.6187152986559944,0.32689396147763494,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0015810688854524739,0.09552977093147838,0.9473666743227858,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07098325596596079,0.1372115898661184,0.6067687621835074,-0.3452653159151972,0.20329880398327566,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0678770281570204,0.02436921850566744,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023257920584194798,0.11101127724122498,0.8347373990826046,-0.24516630185889926,0.19865046069050968,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06462403498094592,-0.02185278066953552,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06968562612921432,0.20907954444681867,0.7400344904323839,-0.48762968027271913,0.3482584280142905,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0095951454536699,0.1736400634558502,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08105900882015678,0.12034992406611392,0.5031147925605388,-0.3216350791054484,0.1595170614651349,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06786250416095038,0.027959411292043677,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.317670531925848,0.11989601602538356,0.01021271972474962,-0.5573392529663672,-0.07800181088532873,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.198954671438614,-0.19770826665266913,0.20575778978442252,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.256642257969226,0.2136275165468051,0.2341831086110013,-0.6836775788008662,0.17039306286241412,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09192801372609885,-0.11162178697632623,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03560988808590213,0.1007642034147559,0.724988769363276,-0.2370346606485567,0.16581488447675244,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02700235940002622,-0.01878539974724439,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02528528360728498,0.08686995669006657,0.771968914692946,-0.19893585271665126,0.14836528550208128,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10437815457883762,-0.0010504504876414481,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09007275310476585,0.07017421483366446,0.20407294159667963,-0.23034900978744233,0.050203503577910605,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09017380913024088,-0.11866005954709105,0.8179445630780711,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12898112159359892,0.07390485712403945,0.08589896969729302,-0.27671482595497515,0.018752582767777304,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.13435935779115704,-0.06983897867310973,0.6537545747431563,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1900090082987411,0.08034179832633086,0.021173150280695965,-0.3506099747803164,-0.029408041817165748,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.19385215791367774,-0.23882516048700642,0.33504311408065957,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027224904048626472,0.08543086400184224,0.7510420875174039,-0.19799876786386134,0.14354895976660836,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0728683763986583,0.018616344554728676,0.9646550643928868,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07364388605292338,0.06442595009440481,0.2574009420720016,-0.2024295252494525,0.055141753143605754,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.050754693248060194,-0.09319869174664194,0.8657833382065884,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054385229882060425,0.08781006157415751,0.537954665224279,-0.22991504187774844,0.12114458211362758,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03747082009418279,-0.020920424872413045,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17119398939184124,0.08731647235020958,0.05442062637810994,-0.34573713058774275,0.0033491518040602575,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01522258570007871,-0.13119395089559133,0.5461326576351918,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10238182385456084,0.11341594789490207,0.37017313086727555,-0.3290970732738119,0.1243334255646902,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004717302168070243,-0.044508985081094674,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13441711673723966,0.08605023095855242,0.12336007541942581,-0.3064290774575298,0.03759484398305049,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.060916659033646486,-0.07645886428170537,0.7248203395110304,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08480368039282592,0.09405454904682486,0.3707356029715827,-0.27281604498484774,0.10320868419919589,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12000192389667103,-0.02602056321493801,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018857495858569502,0.0630409090743496,0.7658404474860482,-0.1448744775060854,0.10715948578894641,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16567614839522057,-0.15431320948616006,0.9686101294099047,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05817738250231495,0.09227301177908054,0.5306900007029861,-0.24262850483958237,0.1262737398349525,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05815790372934572,-0.04335298516477548,0.9460639469661322,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1709753315097789,0.09906765915870144,0.08935642434726727,-0.369008760427194,0.027058097407636206,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00584915793746927,-0.1422463545131096,0.6623259037556665,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04891389139737399,0.07647542524331676,0.5247872839724648,-0.20178608821177962,0.10395830541703166,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.009242230717971632,-0.003195795491331943,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.24909343808566248,0.08844616443482288,0.006506056685381738,-0.425894801581724,-0.07229207458960094,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.027782035021601474,-0.1998391343293123,0.1556009807507485,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09395046832423731,0.1018329957485401,0.35979551252207864,-0.2975117263197501,0.1096107896712755,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.004455594135383792,-0.030127017466522882,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12296007826064541,0.0885704130378219,0.17002156219758072,-0.3000098111751332,0.05408965465384237,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06312375611086488,-0.10162096765873121,0.7842677313995,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01974604517781638,0.12358457089626056,0.8735756726114129,-0.26678808234423346,0.2272959919886007,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3580977464113995,0.20482126087528157,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9585,APC,KIF20B,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1979627640882593,0.07363797324166209,0.009210289844567733,-0.34516297517040795,-0.05076255300611068,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13390347933599983,-0.19935210598066452,0.1972100984392524,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11985576732154223,0.09168397576079215,0.19240939063088658,-0.06077978158652757,0.300491316229612,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13344975684686572,0.29413457815542243,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14027233936980923,0.11261338037061533,0.2141587640286594,-0.08159827224843627,0.3621429509880547,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09235733785852165,0.24391835200391965,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2280188804608498,0.06677013903179649,0.0007523113877363316,0.09646851285741415,0.3595692480642855,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.032767125317647375,0.2775195062258137,0.028989552407043692,0.27704431880498176 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08053037470855055,0.11668555052102499,0.49078756746932006,-0.1493632167626353,0.3104239661797364,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.187177694220206,0.32128481889957,0.9419198731133068,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09587538823788316,0.08985722361799595,0.2870875260031767,-0.08116109798453358,0.2729118744602999,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19213995819091428,0.2907591614744614,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2554682372504214,0.07941269397237913,0.0014794570916679454,0.09900953825818509,0.4119269362426577,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.04866872360085526,0.3261259915257902,0.04997417188791553,0.4775879328570332 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08337340907372601,0.09351963118991784,0.3735769218166818,-0.10087874375334613,0.2676255619007981,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17185387165211707,0.289096758999981,0.915824547329523,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21347716875937997,0.09829100006239996,0.030873283816991896,0.019824476435936433,0.4071298610828235,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13150394521191897,0.3134902363680174,0.42002168600416523,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11963002533159181,0.05304692945512342,0.025051375194060036,0.015117092286299497,0.22414295837688414,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1053557368465991,0.215637279449691,0.3733081872128039,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07533970969349517,0.10786207125758278,0.48557239198243285,-0.1371698841182824,0.28784930350527277,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.18150433583045486,0.29678900194787483,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16732468723305846,0.04145833336401498,7.378029720449574e-05,0.08564357838191798,0.24900579608419893,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11992544128112197,0.3176260493941364,0.003730369421715205,0.0356500038641133 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05493085946191975,0.10614105844569964,0.6052793354410309,-0.15418799904008657,0.26404971796392607,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.18179121768208342,0.265403772641461,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14622971587690758,0.0794619020205367,0.06700346171333926,-0.010325932693658835,0.302785364447474,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11930625428228896,0.27978879694246583,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13634654694097745,0.07254677285555013,0.06143397181741178,-0.006584930752154938,0.27927802463410983,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12583178903213837,0.24286120966438798,0.5784562420554139,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01996289942217283,0.07647352295948526,0.7942897103675274,-0.13070505189749346,0.17063085074183912,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.038112718684805744,0.04345069777332306,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16003534489115248,0.12908198127153028,0.21629799481530487,-0.09428166468049479,0.4143523544627997,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.056965278256045165,0.1010231307777389,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.081777703612733,0.06457759004815136,0.20665305767540892,-0.045452909247497744,0.20900831647296375,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07038694911365545,0.13148127801621146,0.8206162940607284,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17833606273331995,0.05715895518622034,0.0020366728898343163,0.06572162646571163,0.2909504990009283,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14183044516486124,0.3610233962195971,0.06441079442033786,0.6155543353451172 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11196252194025828,0.0790718016550218,0.15812254151695954,-0.04382455182681279,0.26774959570732937,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1063809319465681,0.22880745348122195,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11136804862642906,0.05364125256379696,0.0389756170169307,0.005684181619414877,0.21705191563344323,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08870336132857048,0.22948194794194318,0.4740874443660114,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24938212282271044,0.11966349413444362,0.03824749861823477,0.01362139399449483,0.4851428516509261,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06895084941405953,0.31780667914019495,0.4714419938378068,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1629103956281092,0.07606178107250987,0.03324569338853923,0.013053657185557788,0.3127671340706606,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12861283005253207,0.342348537714292,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17812318530100726,0.0732432653607203,0.015772871328842235,0.03381947974648697,0.32242689085552756,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.017132844869104435,0.15114102249360434,0.2751759397985707,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009428505357194271,0.1516080096836773,0.9504648235763055,-0.3081262420208164,0.2892692313064279,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.18762451023199084,0.20517319678456675,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14876579455219005,0.07102265869027949,0.03728488442118273,0.008837122928032265,0.28869446617634786,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10354290874297788,0.2527307705753527,0.4631727895701855,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.161972413329249,0.08631589265255094,0.06183559468107034,-0.008086951127884712,0.3320317777863827,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15314968247617228,0.33724739270688836,0.5795602425469765,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17056734403238402,0.06862225302917553,0.01363602155220463,0.03536794587829073,0.3057667421864773,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.01696982694187771,0.18388369482015302,0.25114324612853905,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2087564455483719,0.09257716831127101,0.025065918844094797,0.02636113082192948,0.3911517602748143,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1645159978533958,0.4051734319293246,0.3733081872128039,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15832571926675798,0.08524127925724945,0.06451841650705405,-0.00961644445913018,0.32626788299264614,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07098742829719756,0.2246861814824587,0.5880149074273526,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07442905461362778,0.06464780660018395,0.2507886677986816,-0.052939898728825624,0.2017980079560812,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15995491680337423,0.2558335332396128,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07530408201095079,0.0785488745447646,0.3387082703628411,-0.07945272201905446,0.23006088604095604,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13150587241107334,0.18072201870931165,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1569549462544443,0.12194830872907149,0.19935005689933533,-0.08330731880220207,0.39721721131109067,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12008584797731087,0.28813082521162264,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08466270362534394,0.11199580314034657,0.4504455518033439,-0.13599115881664664,0.3053165660673345,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15411122412381562,0.2687889331383311,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1373822891969491,0.07668458046032098,0.07450691079717624,-0.01370148710410865,0.2884660654980068,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.05823203221300191,0.2005482652656728,0.6251964671331764,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09935650757215501,0.10839705776391349,0.36030114775201205,-0.11420711536987747,0.3129201305141875,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09904322775785213,0.20049320022389175,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11491926061421727,0.08470974521929288,0.17621372187744674,-0.051975676026317266,0.2818141972547518,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19253412423399913,0.339565680638477,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06230292690576786,0.09879097603216741,0.5288848419944132,-0.13233481687285495,0.25694067068439064,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11060231894565442,0.160981785149692,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03709401014806032,0.06202971717020199,0.5504181646438857,-0.08511678968555009,0.1593048099816707,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.22769016253257882,0.3061411220194349,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11638497945013655,0.050033548379309886,0.020870126341914756,0.017809002565198073,0.21496095633507503,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06841554665730257,0.180965793648805,0.3333341305877653,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07441442495745777,0.06374767014475854,0.2442712502052233,-0.05118108170176981,0.20000993161668534,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13599648396296837,0.20733502706706858,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1714057060883382,0.06143941657756066,0.005709961807250491,0.05035791506502116,0.29245349711165525,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.0700657144124973,0.2448730571147069,0.14434928925463184,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042890683558262116,0.05104253607586522,0.4016055846227793,-0.05767319846382142,0.14345456558034564,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1145550919986085,0.14815407680097376,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12221725493291379,0.05766332394183991,0.03510648216876727,0.00860911255398758,0.23582539731184,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10478069856398141,0.2231746302697635,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08787057374347783,0.0825590660219598,0.28827833555871074,-0.0747870999063132,0.25052824739326884,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1497492572198856,0.20472221208176894,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08587098333081837,0.06365818144446214,0.17866616384929357,-0.03954821290595019,0.21129017956758694,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07758627779845766,0.1698640398552838,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08410496474534086,0.06896292739531211,0.22386184497652384,-0.051765629226945845,0.21997555871762758,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09201965089587313,0.16885803835658364,0.8356888710841501,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0907403031946963,0.0678430836311767,0.18236274171066058,-0.04292397728226767,0.22440458367166027,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11391145871802043,0.19192764381322405,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.068455411044276,0.047277840494473866,0.14897845697681666,-0.024691276782491847,0.16160209887104382,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.055717195174954534,0.11755615947335518,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1004693641334813,0.059223619175184566,0.09113794663962428,-0.016212868167867156,0.21715159643482976,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08860568519630387,0.15616069115025208,0.66475521554025,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10061704859719582,0.08208995654566768,0.22155182787639982,-0.06111638668874973,0.26235048388314136,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11480375867449807,0.22347593948027186,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06603978072250645,0.06697215168623734,0.3251175814801446,-0.06590859172767045,0.19798815317268337,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.07531672794464803,-0.053121098255111875,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1534906646462953,0.03838083162773365,8.538202328263983e-05,0.07787284232680677,0.22910848696578381,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.23094235873786273,0.3968981911074089,0.004236015630109969,0.04048231059979825 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3132419035669142,0.10512732775478602,0.0031914002689833326,0.10612029483814961,0.5203635122956789,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06893266591869333,0.41127903230744006,0.09145608424256206,0.8740179290727966 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16775543954692507,0.06411315459343866,0.009463143660696035,0.04143985630444649,0.29407102278940367,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12234302429333217,0.3342562524424017,0.19872601687461675,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14859904268460422,0.07435456217053783,0.04682248199657209,0.0021058628236368115,0.29509222254557166,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14483277176589437,0.31014665150302356,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017297034526085706,0.14268106354371715,0.9036144030640773,-0.29840692333861085,0.2638128542864394,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.244013747117123,0.2268877458922073,0.9884099671383002,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16754683124544895,0.063694298417071,0.009094823533069438,0.0420564774359643,0.2930371850549336,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08590303756743348,0.24202287616548862,0.19636616606057228,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03370237764055106,0.13298087633444886,0.800153418410496,-0.22829622562270008,0.2957009809038022,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.20574920884878073,0.31702693613934535,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10819580757997391,0.07052815659035001,0.12636677626623105,-0.030758597194216503,0.24715021235416432,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12206409384747158,0.22128913452002105,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08474245680313164,0.0900955989115319,0.34789231725991454,-0.09276367585026377,0.26224858945652707,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11631672595054388,0.19401940851882996,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10352879001250716,0.044198437007181686,0.020004983480343207,0.016449135542666693,0.19060844448234762,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10678143507366049,0.18675182227673642,0.3247434741655713,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10480222375912623,0.08390361214805112,0.2128896677244708,-0.060504471439996294,0.27010891895824873,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.006424212226480463,0.11055235471111788,0.8287975391843301,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1120698384733124,0.08557378509189968,0.19161150898615587,-0.056527427449647644,0.2806671043962724,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13522711358839598,0.22359176524612198,0.8125064948355263,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2081705721582142,0.09856004785272887,0.03574095465829469,0.013987802524256049,0.4023533417921723,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11814048112740193,0.36465209780631247,0.45290755634531366,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15178599997994777,0.09161566993183556,0.09891212287211433,-0.028714972947916,0.3322869729078115,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08423609627570493,0.2417649359093566,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15920906809704935,0.09046182060765977,0.0797270030759391,-0.019018593662748412,0.33743672985684714,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11404279769425982,0.2776169826633408,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15441064689633383,0.10199276453242634,0.13139703996920032,-0.04653525289791352,0.35535654669058114,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10045158921458015,0.2655451340932474,0.7364614878814166,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22596927772793415,0.08204462131875916,0.006347438821098188,0.06432516179719261,0.3876133936586757,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17529072271932641,0.3949905070245512,0.15361576024962625,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1272936284189617,0.0816535945720884,0.12036612844077087,-0.033580087554355514,0.28816734439227887,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1228927659928079,0.23451550767591636,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12125130969679425,0.07244832675501962,0.09554628621555532,-0.021486209725444835,0.2639888291190333,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1301451159349255,0.25452141940139256,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0625582613863226,0.07171194989761608,0.3839129304764035,-0.07872845011952188,0.20384497289216708,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15129353110075014,0.2202781134276817,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05737943783966672,0.080840436595705,0.478546356063965,-0.10189219624099541,0.21665107192032887,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16869885741462745,0.21592895337893417,0.9377193222502479,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07477260438414857,0.06202805209540601,0.22924689346532912,-0.04743491492309669,0.19698012369139384,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10963228116425108,0.165108394613424,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16368099100828654,0.08109939239523899,0.04470858506619757,0.0038991628331427886,0.3234628191834303,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11876931110290412,0.32316389015531394,0.5055162930315735,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1088930228619975,0.042277082717044105,0.010621671655166903,0.025598816001359603,0.19218722972263538,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11339974718926672,0.20792983312124802,0.21078707399678717,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03452840046147253,0.09747945691670734,0.7235003008312473,-0.15752539150486566,0.22658219242781075,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17111831459696603,0.21122738491947568,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09168057405418968,0.04589193826565002,0.04690660815225518,0.0012643874710597663,0.1820967606373196,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10569600726366607,0.17738994941064987,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06133723796906754,0.06959697126961874,0.37905258735739467,-0.07578254772202064,0.19845702366015572,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15281908141222975,0.21893014521183835,0.9183506089424412,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08961812152821787,0.06145471452067531,0.14611026415761047,-0.03145980946589284,0.2106960525223286,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09416292029241405,0.15137592713702722,0.7660655725780131,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07996341123237839,0.08203887982844729,0.3307192366741871,-0.08166939282793621,0.24159621529269298,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07209715436767085,0.1658082464551308,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055811542929488554,0.08703613688413893,0.5219933540685984,-0.11566684498339286,0.22728993084236998,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1282837996453106,0.18987025192562706,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05120995088402254,0.07088284653764938,0.4707368141573818,-0.1908631649407615,0.0884432631727164,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08559496586390608,-0.022364269073111474,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09867583497873746,0.0780172720670365,0.20720848913707118,-0.05503360712604062,0.25238527708351555,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1055055659060834,0.20444037782912217,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00198345084019406,0.0684646303034582,0.9769129603688959,-0.13687230107853574,0.13290539939814763,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08329322905849279,0.044922607348525656,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14372973141938858,0.05873961053983527,0.015149294291327957,0.02800109176928675,0.25945837106949043,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08519623113657662,0.24831790138043935,0.26949433460657995,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11958830846129911,0.07683107477541798,0.12094417416600035,-0.03178409058762571,0.27096070751022394,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10681556423940002,0.23931357054739352,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11288955882463152,0.12934256036779204,0.3836733078352865,-0.14194084305681282,0.3677199607060759,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08444452398166977,0.19379921690968488,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19048577436625427,0.07980724948834594,0.017793648288451373,0.033249723043799195,0.34772182568870935,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11590379507094946,0.3605810118073917,0.303536876132493,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11523629422514513,0.100033781201702,0.2505124571450485,-0.08185002131448403,0.3123226097647743,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14760201513781943,0.2729039291501309,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11771768214190426,0.04562499019144493,0.010490610221785244,0.02782743601362328,0.20760792827018523,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.04909293341546718,0.1568654560372447,0.20923232145862128,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1252431206303371,0.07945412985526623,0.11631465324156347,-0.03129721523887463,0.28178345649954883,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10946003567314655,0.2546233073580179,0.7174092598535593,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06246182616878115,0.07488025459570924,0.40504736429260446,-0.08506707164605645,0.20999072398361876,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12218950202863403,0.17245906738817757,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18672635343143928,0.0615981290056065,0.0027096604527017815,0.06536586756345941,0.30808683929941916,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09337995746653585,0.30371403875641384,0.07966401730943237,0.7613247386116051 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15595178707809068,0.10365062463135637,0.13378360494912328,-0.048260424702499194,0.36016399885868056,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13859572852707583,0.29584752023190625,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09096028304382779,0.09974043970450436,0.3627271269234823,-0.10554809178234388,0.2874686578699995,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14578027308735314,0.2698823367642111,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1415871850429061,0.036897236473518676,0.00016021965078874558,0.06889233833409761,0.2142820317517146,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1127350462852534,0.2680077587624802,0.007254849161155216,0.06933238277238057 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17890367996030584,0.054412825815403174,0.0011653997336180842,0.0716996611855465,0.2861076987350652,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.04864342865220357,0.2539674973271523,0.04111530260204601,0.3929264185216215 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1517683098501019,0.08524108851052756,0.0763037828929475,-0.01617347806705277,0.31971009776725656,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15226917584027488,0.3116555819785053,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13131981229561956,0.07360965003301256,0.07572456144736689,-0.013705743460550868,0.27634536805179,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11389233005357838,0.27380274747398486,0.6287673313485338,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11196452359094893,0.04592491221997097,0.015517883105481422,0.021483371802187276,0.2024456753797106,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09969552062926881,0.19489529170314837,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14493115136805504,0.08299000176903212,0.08206473377847964,-0.018575550855928852,0.3084378535920389,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14272267476449296,0.2553187568354982,0.6430699474171485,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12649598564141526,0.05636035675460051,0.02574521252411891,0.015454946086326707,0.23753702519650383,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.042222816391601095,0.17042799486919843,0.37636371457910855,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16021762781065474,0.08267836314247728,0.05385081316904952,-0.002675084739544059,0.3231103403608535,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10018829917206545,0.20972069828902704,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1279255189975982,0.08849517659058564,0.1496429435846187,-0.04642746544172857,0.302278503436925,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.027592091038850658,0.11672272611229569,0.7663649588223891,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12148967152160194,0.08888217201129665,0.17298591174125538,-0.05362577036642259,0.2966051134096265,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11276241134539382,0.19853962001103406,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19243233210296304,0.06927866634007519,0.005921097239525215,0.05593967001980232,0.32892499418612375,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.008026690279421093,0.20208081544780856,0.14734065795407886,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11544682886581624,0.08199764090391473,0.16048498815903217,-0.04610472636440015,0.2769983840960326,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10891818077502612,0.16439104929591938,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17046881905426953,0.06670425107462541,0.01123720519093458,0.039048263745853434,0.3018893743626856,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.02322688385748887,0.1680721557355071,0.22034340329509305,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013980131938340727,0.056699095719525715,0.9803498881313052,-0.11031040905662819,0.11310643544429634,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07230386661217256,0.035524113974039456,0.9985296925363316,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010376723314280672,0.07694850592896804,0.8928446591365424,-0.16198048493997427,0.14122703831141295,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07570948343781636,0.017119161624397285,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06826014780193793,0.07010214591886411,0.33120335760023656,-0.06985493177015475,0.2063752273740306,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10530832045162898,0.17677161799468918,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059798914381597845,0.07716022124923654,0.43912741773318953,-0.09222196825975423,0.21181979702294992,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14135673078558122,0.19112071069736153,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2632392911480158,0.08452417497566518,0.002074373338399263,0.09670996455591713,0.4297686177401145,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1502084578302297,0.45337441356183883,0.06508448838028992,0.6219926232357781 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10401996964645836,0.08434833347189277,0.21873674940502766,-0.062162914437108405,0.2702028537300251,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16991513874992278,0.2809817399115418,0.8335728837144069,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0963682131646639,0.04502660468347447,0.033373442422756194,0.007656904727445624,0.18507952160188218,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08885915105706148,0.19141560417027872,0.43572102952605046,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15380437430123375,0.05891098770226174,0.009619297797140434,0.03773808777720075,0.2698706608252668,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11200365474140729,0.2711370575110764,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09897991734697383,0.0780847691960278,0.2062076990037551,-0.05486250743928038,0.252822342133228,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1789337287123588,0.2614856851979967,0.8201610583485497,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18578775870058875,0.05537703023465907,0.0009265528290105168,0.07668406669409378,0.2948914507070837,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12957393163646225,0.31631380276235443,0.034050816466136495,0.32541327717506013 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10134412126531862,0.07619633906046072,0.18480579919899318,-0.04877772300201598,0.2514659655326532,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11484420716448485,0.20156638242411534,0.8047111541643488,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16580369949547116,0.06882092227709133,0.01676425873701582,0.03021288366614469,0.30139451532479766,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13120630024761176,0.28476453992365497,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.245631252998349,0.04920718716797761,1.1717337081946889e-06,0.14868337098786052,0.3425791350088375,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.05378456201871427,0.2990714049012314,9.588888840875711e-05,0.0009163808877475568 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10842421045767181,0.10914541508898264,0.32154934608503877,-0.1066138242893846,0.3234622452047282,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19622041369353813,0.32023987197709125,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2046119179829034,0.07453870673501889,0.006521942881006634,0.05775593694313175,0.35146789902267506,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14964415399996625,0.39717810293695255,0.1556009807507485,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016462821772685675,0.15957618877328153,0.9179200384363833,-0.3308594457468206,0.29793380220144927,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.129841248889651,0.10419519674050134,0.9901412236863718,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21316089297796695,0.08847421983496186,0.016760019887908224,0.03884919748825241,0.3874725884676815,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11165678950624372,0.3624315891742477,0.28856382563294536,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019327053765939496,0.060222809047621735,0.7485542767072708,-0.09932378002300127,0.13797788755488025,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15177652079845308,0.19697262484267636,0.9639882946953788,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08278487720466163,0.07974361458243327,0.3002819382237926,-0.07432580077895351,0.23989555518827677,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14645229590852468,0.22148215581373817,0.8874303892853559,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19171741654128074,0.0763203387535062,0.01268198779241356,0.04135126837643474,0.3420835647061268,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.03290088258767514,0.15626310859657858,0.2385535997539783,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08859003173656015,0.13579887410858824,0.5148107041290872,-0.3561406474483276,0.17896058397520725,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.23646213105202066,0.050314714477324704,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09476952625301321,0.06962380978221722,0.17477634901290826,-0.04240313661115644,0.23194218911718287,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10192051326186394,0.1935171045064856,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10408316542012558,0.1018874438375341,0.3080531920936479,-0.0966552317939231,0.30482156263417426,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.2067482557981945,0.35709419662081526,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10094888776757545,0.03081253889880263,0.0012123934254255962,0.04024209761093994,0.16165567792421096,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.06530126434076516,0.022399656607055982,0.04239638330849508,0.4051693164687506 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08946210611886095,0.06676499876229458,0.1815652127679021,-0.04207813413794399,0.2210023463756659,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08532298483320229,0.14812225208840535,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11557930249272319,0.0644960347181833,0.07442444614264145,-0.011490630252221162,0.24264923523766754,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10094551719038033,0.2522770699172266,0.6251653475981882,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054938185855869265,0.0885301765944587,0.5354964229296445,-0.11948375550705218,0.2293601272187907,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07393072674101293,0.10174959371567463,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13150241028370394,0.053916497329610076,0.015475669188193982,0.0252762566999553,0.23772856386745256,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10901128554533239,0.2812216378680729,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03188789881143943,0.06378275834054184,0.6175853162770722,-0.09377673852687267,0.1575525361497515,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1337791575200367,0.12244143763536276,0.9570174945596325,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06774918887838657,0.07612878427668705,0.37442210698887546,-0.08223955911615813,0.21773793687293128,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13439977909522263,0.20100734400207568,0.9159127256227925,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21150709850127877,0.09539403185519028,0.027575723858614735,0.02356200598397637,0.3994521910185812,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1437411227421191,0.3839298072381239,0.39228691037577734,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17904519498116578,0.08551279509686642,0.037360601832590275,0.01056809139998155,0.34752229856235,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10256426052526071,0.2914083180258734,0.46338821460484625,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07091666148840864,0.04242775820183821,0.09597162987880596,-0.012674405850594456,0.15450772882741173,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07027298539448505,0.1303267163902289,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18038953904926175,0.09141723789300041,0.049648421986828034,0.0002795164478700263,0.36049956165065344,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11939319522213407,0.33163365265733014,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09165071056926756,0.07382298294099034,0.21567205806522438,-0.05379515316998228,0.23709657430851738,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.132883604150304,0.230860029419448,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19535876665474192,0.06794777134050996,0.004412483912675421,0.06148823070420775,0.32922930260527605,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07959440375047622,0.2845390922450762,0.11833208546897803,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13480483105539173,0.08892783446470215,0.13090258954341683,-0.040400574888695445,0.31001023699947894,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.19963658076418975,0.35882615349142594,0.7360778123788349,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10040096901337081,0.11368164089973146,0.3780511582611752,-0.12357432693441528,0.3243762649611569,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.016818434860036237,0.06587501019846277,0.9171668992289758,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1443439520590306,0.0789226911197255,0.06868854407240724,-0.011149344489418345,0.29983724860747957,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09400864588006344,0.26350465925846545,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16378072190274248,0.09173886064135346,0.07551456290335601,-0.016962961065229043,0.344524404870714,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07783243613347876,0.2893358539246434,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08123458020317303,0.10193220477313913,0.4262930545651573,-0.11959200489873237,0.2820611653050784,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13449005567654598,0.24734602782909473,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19847850262698938,0.07435976040984092,0.008138745076382854,0.05197508120742814,0.3449819240465506,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.011243639882921158,0.19494055511726022,0.18301801251084163,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.35912516766031566,0.33742859184984225,0.28829464689868256,-0.3056758338265626,1.023926169147194,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.4266809307844373,0.8516360144348635,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04876276880206752,0.09437749407306434,0.6058710539530208,-0.13717954341762656,0.23470508102176163,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17067783926906768,0.2517383998317953,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06537592853262529,0.07942619746766741,0.4112911454999675,-0.0911093750136057,0.22186123207885627,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.17383014592846652,0.2633484376962916,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14295315584443613,0.07154467211626388,0.04686865621227641,0.00199601462177304,0.28391029706709925,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.05047457998875105,0.19835763950246638,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0883286975034814,0.07772354183535447,0.25693695305739833,-0.06480203800409144,0.24145943301105421,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.15060100451416905,0.2407256240510758,0.8649556969336845,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14025076999810315,0.0895718000956895,0.11875452405642098,-0.036223375485975456,0.31672491548218173,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.057880818293774054,0.18466762131420666,0.7212497413617978,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15083695580555398,0.09073791969370136,0.09778999186013244,-0.02793467571064115,0.32960858732174914,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06186838208337288,0.21624105076657704,0.6772213442508546,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0865829110664211,0.07712405572700169,0.2627439180232348,-0.06536671834985833,0.23853254048270053,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09516123289888595,0.18505556631505546,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02421213219005864,0.0663120592130787,0.7153499696055949,-0.15485999203451925,0.10643572765440198,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1198238576638391,0.054513851907576585,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09246042616067385,0.09376778501379125,0.3251277389299938,-0.09228063873436926,0.27720149105571695,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1587879647319978,0.25235743360891955,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15491911387248883,0.04377684856086349,0.0004850268290813727,0.06867007194733858,0.24116815579763906,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.03840210941092264,0.2031807866066011,0.019543872940344854,0.18677483838120149 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19940897093657578,0.11117075592276857,0.07415484948908407,-0.019619385458304522,0.4184373273314561,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16917037680087033,0.4099941352929603,0.6242218401318658,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1440375525039883,0.07675968498612545,0.061840202247075975,-0.007194194553481303,0.2952692995614579,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.097928236400515,0.23975051443348666,0.5795602425469765,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09597901960184588,0.08543058277999446,0.26239254745499097,-0.07233610947003136,0.26429414867372314,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1331148122176946,0.2271079315894656,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14837040841322519,0.11527793931349967,0.1993481362482993,-0.07874991083660896,0.37549072766305935,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.14810116625513228,0.315501989389785,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1097759351995932,0.05845845649753687,0.06165144822617039,-0.005398775431431205,0.22495064583061758,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16313508665268459,0.28721937228487643,0.5791588118572077,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11594476130561926,0.16569599830423584,0.48478528364644824,-0.21050909671256451,0.44239861932380303,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,-0.016922540132795847,0.10272682767615024,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11016263274012209,0.09899335681244557,0.26692885788227805,-0.08487384116588273,0.3051991066461269,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1559973006181178,0.26977400891036313,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00743940683963749,0.08209604581660572,0.9278737166428774,-0.16918483919256463,0.15430602551328967,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1130868735318356,0.07882717289362162,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12376655686578926,0.06478603598950697,0.057310747173138936,-0.0038747356876156352,0.25140784941919414,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11434987099601081,0.22272684698237175,0.5602619594339617,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05371178666835154,0.0836872211075021,0.5216236502677429,-0.21859214875894545,0.11116857542224236,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.1337186509098624,-0.0030766433643655685,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11505828011135975,0.08618174144063256,0.18315780700858417,-0.05473677995015326,0.2848533401728728,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10395936617622992,0.2221086654045237,0.8023767505707181,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07668198589322477,0.09043367856953974,0.3973437331727261,-0.25485420227708827,0.10149023049063875,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11972788272796392,-0.0639858855516934,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08681696609603465,0.0740563315751104,0.24226990650864866,-0.059088640561881844,0.23272257275395114,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.11133892622146574,0.17681187721900754,0.8494428082445464,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047677315886761974,0.07628162850022269,0.5325715038890866,-0.19796719720353323,0.1026125654300093,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.13575576339659534,0.025909727891925798,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10397403729097347,0.07467831481145851,0.1651612814410439,-0.04315699924579654,0.2511050738277435,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.08756981484607843,0.15476959508831603,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015962909722763562,0.04825113613964961,0.9736367444180363,-0.09666056354225883,0.09346798159770611,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09482940766644944,0.07627576849028592,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030249739993900574,0.06880652139494745,0.6606091318575869,-0.10531270325200293,0.16581218323980407,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.12278779225043585,0.1339465821443878,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0029646227985941236,0.06335875995934169,0.9627198435316275,-0.1277938995442979,0.12186465394710964,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.0930662051402257,0.08362045622177054,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09976119381637052,0.053301364915010814,0.06250885033026335,-0.005253027361085141,0.20477541499382618,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.10413652301550345,0.19871264863475455,0.5810248874960544,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09531116389516554,0.11277777911168013,0.3989088084443764,-0.31750567351833087,0.12688334572799975,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.16728109573256914,-0.043765775826262406,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12660851999642744,0.06825996040473821,0.06488821594110031,-0.007877090098874384,0.26109413009172927,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.060844690226611126,0.16411395295759365,0.588665895017662,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039940400885650346,0.05420000291301601,0.46191982025034883,-0.06684431471781967,0.14672511648912034,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07950724656131208,0.11463734071854344,0.9370609591482926,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11631457582020528,0.06992159168355504,0.09755676404275333,-0.021444776230997317,0.25407392787140787,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.09271300260190694,0.17289592085060415,0.6772213442508546,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019731395395227343,0.04900423215695757,0.6875772759851836,-0.11627941593030491,0.07681662513985021,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.0994297699200997,0.0835926997743843,0.9632925656593531,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08073629662010934,0.07651150693671506,0.29241870128496,-0.07000649064029449,0.23147908388051316,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.07944480024360207,0.14816625215569187,0.8801800464438181,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06851277926917002,0.06489935166091336,0.2922090018170601,-0.05935176754796559,0.19637732608630562,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.06997639797196951,0.11639981755982412,0.8799526010712531,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22377084576267856,0.08845085879155892,0.012070360107910075,0.04950517614458594,0.39803651538077117,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.2197158072808223,0.5223751460579893,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06279889077616002,0.07439774607039489,0.3994811835479066,-0.08377936990061999,0.20937715145294003,230,7,237,2,log_other_mut_burden|lin_Lung,False,233,0.016822466962316308,0.010581322546273956,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006419626274114722,0.12643634502940737,0.9595370363745601,-0.24231448893544377,0.2551537414836732,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06621141898262324,0.109534089653939,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037291242991096124,0.15812946773405567,0.8137147801966479,-0.34837420917649664,0.27379172319430445,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.028209879662149866,0.019392291632308874,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047975662885301334,0.07352724653965567,0.5145460826864177,-0.1926234270039384,0.09667210123333572,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.018199137784080374,-0.006971733560578074,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046586025678629205,0.16149781648934958,0.7731762359504093,-0.27112338361670446,0.36429543497396283,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05325527488802479,0.13102048267176367,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010090562915665634,0.10087324196854744,0.920380322936109,-0.20853521570542013,0.1883540898740889,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09338199109707981,0.06599426848385495,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11843078561865256,0.09338829620433432,0.20564769755098183,-0.30215054770059624,0.06528897646329115,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06559499583498754,-0.030042056276512415,0.8194936863251474,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09677219888885621,0.12081502879789774,0.42371809528314697,-0.33444768124381524,0.1409032834661028,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06695930013275722,-0.017559431304913893,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016582142863230783,0.08737721179113533,0.8496023665906296,-0.1884764938055274,0.15531220807906582,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09775982397684507,0.06546365059816817,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017966962254319964,0.08934474448881145,0.8407481185712402,-0.19373197637173856,0.15779805186309864,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04244265647582276,0.017582476141464447,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025028193007659332,0.1589653073848437,0.8749921156349244,-0.28769909337655325,0.33775547939187195,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04812108929792848,0.09253890679712207,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003632948676730901,0.08395342816187334,0.9655101027127299,-0.1615259039284746,0.16879180128193638,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07670298657044866,0.11411448916564575,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03244899698520132,0.16192593528345603,0.8412973531760974,-0.2861026365094469,0.35100063047984953,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.048215492049292166,0.08729425852910172,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0443595334086901,0.11546280262727937,0.7010888762398934,-0.18278668822902372,0.2715057550464039,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06264865663292267,0.12869507671156413,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044017226652312655,0.10999156927987931,0.6892806883449004,-0.1723656153143575,0.2604000686189828,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06661205403908087,0.10486054101192926,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043380853302158975,0.1622186330290487,0.7893132614022434,-0.36250830156555025,0.2757465949612323,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.058638004625385015,0.0516836181177098,0.9727286373504853,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12683256536954335,0.11948681730559238,0.28925869398134857,-0.3618951003929981,0.10822996965391143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.036022470418822825,-0.10181785501874856,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04258294122637975,0.10928633988942481,0.6970530555044979,-0.17241252586470635,0.2575784083174658,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.01750774301991059,0.04661920908649366,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048165033509608775,0.09901368190301599,0.6269762315017591,-0.14662136715753485,0.24295143417675238,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06592822664834058,0.1413129717384082,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013377830841380466,0.12144800056470612,0.9123560153798638,-0.22554287631292794,0.25229853799568885,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03499955295221479,0.056504676237275536,0.9895179737785706,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015800546572278855,0.08435818843378676,0.8515395442525491,-0.15015457777016283,0.18175567091472056,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0396880803275394,0.08577179603923894,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056060918837943334,0.14108617994657877,0.6913677152347626,-0.33361517848651734,0.22149334081063066,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.017597082636061304,-0.008342934327109931,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08952325757262454,0.11915355622802912,0.4529980425463147,-0.3239301789017559,0.1448836637565068,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.047031984653059196,-0.004569378083340732,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0072490770255082245,0.09506536556412704,0.9392641092001306,-0.19426808319154878,0.17976992914053233,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.03411611561877194,-0.03488674387966933,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020078869751380277,0.1525495292999669,0.8953644993288818,-0.28002686477642946,0.32018460427919004,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06902436260473498,0.08846836522089191,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0027033345661921053,0.11147382210874682,0.9806673573964779,-0.21659549525048646,0.22200216438287065,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03793854162408856,0.04781000326948154,0.9985296925363316,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08662254375273197,0.0697634988242773,0.21525464236774414,-0.05062092172346257,0.22386600922892652,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1254943422036502,0.2250008453444671,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015126285845816932,0.08741825146743695,0.8627324793685143,-0.18710137281042574,0.15684880111879188,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.0014691744500724018,-0.001991932261791057,0.9850935588646815,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051420592444764004,0.06572164515563018,0.43454766605275086,-0.07787146557937534,0.18071265046890334,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1550446701413335,0.2239540027934016,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04810973313811974,0.09841252672012273,0.6252710693425829,-0.14549403446187992,0.24171350073811942,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03184639599924867,0.09486700974160782,0.9596677781209249,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027525664945372914,0.08807347838573124,0.7548370632087584,-0.14573842865530648,0.20078975854605233,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09517412169121545,0.12058649780745398,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08101641494271888,0.11401921557894044,0.47787081089748085,-0.14328988477924318,0.30532271466468097,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07748977209067488,0.1557137263287411,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06046434401139439,0.13230457827028264,0.6479691642498489,-0.32074284388877083,0.19981415586598206,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.01745432134239765,-0.03253655111641918,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06277057248521395,0.13978026006262043,0.6536823715855182,-0.33775573835940376,0.21221459338897586,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0397025111800134,-0.01518200162909603,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03289205230246284,0.09604480215709797,0.7322211322794705,-0.15605376766304202,0.2218378722679677,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.015279138540119535,0.062920277912941,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019723826997877024,0.13698163098843535,0.88559824485609,-0.28920334078757115,0.24975568679181712,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.009753867418065878,0.007849040839417022,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062432775687239546,0.09607686376720236,0.5162653901731359,-0.12657611804253502,0.2514416694170141,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.118311876157498,0.16823171382476348,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04977355742056394,0.14026691637360253,0.7229322596902634,-0.2261689916087236,0.3257161064498515,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05388009060618992,0.09592188488290758,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050242251284243075,0.05334098011546059,0.3469376266316446,-0.05469372650239614,0.1551782290708823,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15791541242211507,0.19107638479628375,0.9086080106242148,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020136082497718914,0.06228406507288804,0.7466796586527886,-0.14266550086991328,0.10239333587447544,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.038463814086873445,0.017791770825300736,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051309093813997494,0.09478420416663245,0.5886530707547482,-0.13515679266623887,0.23777498029423383,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08911929629674564,0.12752350778483051,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05105955372848825,0.06659185400806403,0.44378283381870054,-0.18206354536560346,0.07994443790862696,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.036242321785108264,-0.011836634125008497,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07737637034194596,0.10854287226314552,0.47643948795127167,-0.13615649703410948,0.29090923771800137,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05624771557757225,0.12447028665633297,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004631793129470662,0.08476980580232168,0.9564590135644542,-0.17139667895262906,0.16213309269368775,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05422697716773292,0.04286359146209311,0.995720872088477,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07262254462814684,0.11380868713887038,0.5238495760752578,-0.15126958933115342,0.2965146785874471,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09840946241901262,0.15927090324417087,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04228269233575785,0.0860047207092464,0.6233102065133601,-0.12691160147654776,0.21147698614806346,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04606342745856583,0.09093792809917987,0.9586972329593203,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03849223907827824,0.09380091674116732,0.6818107051708675,-0.14603925798479434,0.2230237361413508,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0616167693144715,0.09663333824999781,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04287576190799811,0.13097794185392186,0.7436125176382162,-0.21479288923362497,0.3005444130496212,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05176812385419897,0.08668457583091918,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014612721775765593,0.06533624731030153,0.8231665264114075,-0.1139211555841099,0.14314659913564107,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04027903226742018,0.051610610239108186,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022323076431218565,0.0702682232695772,0.7509281830518202,-0.11591331705390492,0.16055946991634204,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06575702616659902,0.06259053669083832,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043147288281999555,0.09977146670257152,0.6656921772556545,-0.15312987781017162,0.23942445437417076,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07072405503678529,0.12056817004339553,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003045892369902617,0.06120032718892244,0.9603367758867293,-0.12344330840032913,0.1173515236605239,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.08914524398754384,-0.09873123912294338,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004754367940727429,0.08065666853106836,0.9530314329159594,-0.1634276123955538,0.15391887651409897,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.20307726763446027,0.18215119167713942,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1248353759383276,0.1299602774844445,0.3374825100770047,-0.38050200901731707,0.13083125714066185,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.024512810637070302,-0.06386465323489086,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057960053930853114,0.10719126638180326,0.5890724597768722,-0.15291384309194267,0.26883395095364887,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07633732130063409,0.1631632109309822,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008531958565618232,0.09237639506530186,0.9264681070806474,-0.19026104040100592,0.17319712326976947,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10382956255920585,0.10461557240162149,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12417334172794747,0.14707809720608062,0.39913874054038856,-0.16516862214131112,0.41351530559720606,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.11613348039253325,0.22458001336407568,0.9213036703720862,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03700633511249015,0.10370514166249908,0.721441064506449,-0.24102209219645257,0.16700942197147225,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07969061480682486,0.04817838811905683,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04632174678569739,0.15080880262603422,0.7589211612963237,-0.25035951269135365,0.34300300626274843,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06699064849691959,0.1517393859397447,0.9671401795424975,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018933170452516215,0.10196187513026109,0.8528043530482188,-0.21951945590496474,0.1816531149999323,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0634374101424466,0.04187269891723792,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06254214102532486,0.12844101257137905,0.6266331839394466,-0.19013569153248244,0.31521997358313214,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04499215101620129,0.11337715778016975,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009565114375042753,0.0743540866606296,0.8977196612807992,-0.13670926545968748,0.155839494209773,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0981543148566631,0.08940705598020425,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013318977346400624,0.08765423215938431,0.8793211125861684,-0.1857583014621578,0.15912034676935657,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.03980992732900809,-0.043541165286233655,0.9864402192918322,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02626941009502575,0.12642907685992213,0.835530634847312,-0.22245040668075816,0.2749892268708097,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.052663339045276876,0.057145633265411146,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003317369963850285,0.1303296577420724,0.9797086645826782,-0.25971067282703497,0.2530759328993344,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.02057758779178553,0.0455284327766113,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13280395693930294,0.07465799908321327,0.07619925026413116,-0.2796762138125932,0.014068299933987366,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.053524098446356604,-0.07620288596394251,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004490085307379051,0.09755388015408743,0.9633171330186061,-0.1964046654049178,0.1874244947901597,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.051785860904806115,0.048705517181973586,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11172431711065682,0.10401809047904138,0.28357874569792774,-0.31635572823753244,0.09290709401621881,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03748748433818959,-0.07203497084346579,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006819870251474729,0.09936315873245223,0.9453215977002645,-0.20229378533495052,0.18865404483200104,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15178771396157842,0.14293468539799745,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012572427066703945,0.09622097915116433,0.9895829686365138,-0.18803516453743052,0.19054964995077128,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06749778625907417,0.05017037500091054,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07879802734414695,0.06466933184456598,0.2239241910803713,-0.20601990356818825,0.04842384887989434,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09896553967601776,0.01568082405822953,0.8356888710841501,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06369970632541169,0.08912187328582956,0.4752761009491323,-0.11162686051273368,0.23902627316355707,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08968267114829415,0.15010689802675523,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02353207157803435,0.1058417334308314,0.8241941715947916,-0.18468693310009537,0.2317510762561641,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10201785372422899,0.11646001451561104,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005913128560774649,0.08169548702139483,0.9423437969738444,-0.15480374977159372,0.166630006893143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05538115106859247,0.05493174086336127,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06316041448919685,0.15471869842761368,0.6833747165618482,-0.24121265601372055,0.36753348499211425,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0372923845538869,0.14655949102797539,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017163948221997176,0.06993608298553708,0.8062830738682207,-0.15474693291349448,0.12041903646950011,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07870701121358985,0.042740906929640984,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09199755067101906,0.13720564709603866,0.5030084202508969,-0.17792266273162605,0.36191776407366416,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06575741460144957,0.1571008039073374,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010049346044687227,0.10950223423795051,0.9269347812281166,-0.2254695350758673,0.20537084298649289,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06655915099894358,0.047859945661625644,0.9916453225591361,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04319717819852249,0.0914308169518257,0.6369163699742888,-0.13667169852446404,0.22306605492150905,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07763754941835434,0.11643268929459372,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024934699554938173,0.10839382946295611,0.8182065182322477,-0.188304960760878,0.23817435987075436,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.026385085792732223,0.040627533733511106,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018688885790146527,0.0862361415928893,0.8285640216130337,-0.1883384463908154,0.15096067481052236,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.018853450999595216,0.004936496222277838,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06992255601282388,0.11708428836511413,0.5507894402040319,-0.16041356185473934,0.3002586738803871,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05814555034818394,0.1421871007849227,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07367551129252714,0.11773230873851975,0.5318916129601482,-0.1579354360093995,0.3052864585944538,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03922076519027215,0.07344085649254542,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06975314564511523,0.11636261342575051,0.549291639936244,-0.1591632445526093,0.29866953584283973,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06946694360575675,0.13714784082022596,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043552975689263675,0.10739055837443336,0.6853342798822086,-0.16771298199807969,0.25481893337660705,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.025774452294892163,0.04184807698919794,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034058745513633124,0.08940662251948081,0.7034943463908396,-0.1418279992438627,0.2099454902711289,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0457944132276392,0.09640475361879199,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013479958641007237,0.07410120115336395,0.8557642013285927,-0.15925684503044363,0.13229692774842916,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06737541259984973,0.06238549732906118,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01989190260548445,0.17115102816179037,0.9075463680069547,-0.3565917617095079,0.316807956498539,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.017603878980256716,-0.04052384710881837,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014400160550780257,0.10756260356687239,0.8935824321377157,-0.1972042560560093,0.2260045771575698,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04401463752717093,0.09496060053554031,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03160112523037417,0.12505361702886977,0.8006588383168508,-0.2144127940916078,0.27761504455235614,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0704595151905762,0.1069406681025227,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012495962904131998,0.07497321512968116,0.8677311819609721,-0.13499640825986967,0.15998833406813365,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.044586180609344196,0.05478421142153031,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002834744475516973,0.12355075189011439,0.981709005485999,-0.24022263706865538,0.24589212601968935,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04196731351401767,0.06826755267986839,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034129727243492856,0.11901740191094418,0.7744763487300997,-0.20000934211962185,0.2682687966066076,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07641049579064614,0.10312122035982191,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012722904146065164,0.10253906201531146,0.9901078031223015,-0.20044947605107577,0.20299405688028882,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04729370246240617,0.07734495504314871,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025450695086375996,0.08464819974629434,0.763862119276187,-0.14107495909224974,0.1919763492650017,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0941136543490562,0.11718714435145913,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05258831588332065,0.13929521174256726,0.7060244025702389,-0.22144263018410199,0.32661926195074326,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.059830905272040324,0.1386953049142877,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0604164692310764,0.062218678313720334,0.33225111144907105,-0.18281725435557433,0.06198431589342152,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09318169017182719,0.04385306520037914,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04197355698045369,0.07236423258594517,0.5622938316646013,-0.18433336152002136,0.10038624755911399,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07332336431836976,0.056851913520771076,0.9512976205783472,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048215441932345546,0.13783381585789167,0.7267082878976617,-0.222940547473991,0.3193714313386821,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06649898084958648,0.12020461723968721,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02413158401685335,0.10838690578910253,0.8239528070060179,-0.23735762361396268,0.18909445558025595,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05740022943184874,0.05555825358017411,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02057579397814501,0.06579863244432858,0.7547020531147177,-0.1088677186386775,0.15001930659496754,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.056750903695976185,0.07163850678140123,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06681115369844165,0.10769834450011684,0.535457828291163,-0.14506030163776093,0.27868260903464426,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10144528206027086,0.14504265884334308,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003286615977736298,0.057472556921114026,0.9544321983289994,-0.10977727867438586,0.11635051062985846,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.030552928683960215,0.03815332394026673,0.9946097045025434,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010470872939035696,0.07987033573064042,0.8957783344188635,-0.14665544453582138,0.1675971904138928,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05647818369494686,0.04032793251001892,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09583630647945852,0.06266885793986557,0.12717236268279708,-0.21912271536165492,0.027450102402737875,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.014090167430879418,-0.06041746153754394,0.7267776925673457,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07701962825018668,0.09133319804489091,0.39968913943443496,-0.10265720596762859,0.25669646246800193,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.060384198331904095,0.1206968153447936,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0716718966667956,0.07936316102607037,0.3671461398860135,-0.22780046581724042,0.08445667248364921,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03536050245482643,0.00017553694822498086,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01046414770308158,0.08025933563616662,0.8963468386083009,-0.14742743665207925,0.1683557320582424,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06919419600820144,0.04099004942469297,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09363692468828906,0.06920449490177809,0.17697821663640614,-0.22978067990293516,0.04250683052635705,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.02010214135215789,-0.037985277112655674,0.7922027988136138,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03482777188031991,0.10379151504414141,0.7374222297744846,-0.1693579047521352,0.239013448512775,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.02556633484956902,0.02946121482360326,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04964670724995643,0.08065553707598781,0.538627657348916,-0.1090243113300371,0.20831772582994995,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03737063445327788,0.05088727758389577,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009200255310263559,0.09238307946279575,0.9207325537095938,-0.17254197652321973,0.19094248714374684,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06923315058263049,0.0742504914411913,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053197441695885174,0.114262688773076,0.6418331814051883,-0.17158783493344057,0.27798271832521093,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08041744531204582,0.12431706943268968,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10445221827760726,0.08374841227481203,0.2132141842716913,-0.26920774978664974,0.06030331323143526,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10348111150682447,0.025602944000113502,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07299874370828752,0.14486165377771643,0.6146576783807085,-0.21198288298942453,0.35798037040599956,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06347740917817157,0.13658843236437127,0.9557595790374268,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05035773865952716,0.04631632096441419,0.2777265094938182,-0.1414743326433693,0.04075885532431498,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06258702559660966,0.005583608362658268,0.873574778219852,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008425693143705844,0.09223190884787126,0.9272679409366344,-0.17301914564871648,0.18987053193612816,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06130839590704423,0.08388741371274477,0.9916764739841218,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013235061053024334,0.09460063791244706,0.8888217906600705,-0.17286970149717026,0.19933982360321892,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10267063678508508,0.09818809964748255,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02668039085820362,0.11106545955912427,0.8103089773145141,-0.19181508057729538,0.2451758622937026,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07924641824890989,0.12669436334161469,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010986076806300052,0.09894102882191003,0.9911475339141829,-0.19354486493966178,0.19574208030092177,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03963017674990471,0.03247644073723244,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00823294865041678,0.10734038154684765,0.9389096886528412,-0.2029342977936472,0.21940019509448078,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0757339892153282,0.08184216378981429,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0480299779208789,0.08352304129113783,0.5656537088192531,-0.21234214441327948,0.11628218857152167,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.058798711597882025,0.023167773437662954,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06727887019259657,0.144488947273658,0.6417888996149222,-0.21696954310434644,0.35152728348953954,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08695371796687289,0.15296070822216934,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0030646727848396803,0.11121784888230336,0.9780334674443585,-0.21573058921688867,0.22185993478656804,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08499539427549818,0.10982779680877708,0.9984091646827826,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09745812513980708,0.14299868224689816,0.4960190236121369,-0.18385853817043202,0.37877478845004614,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.025776793643755343,0.11450452889399038,0.9428637474696224,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05566325845787794,0.0934527900201853,0.5518358993912789,-0.23950989712913184,0.128183380213376,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06675623445981352,0.03422327684006761,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0904509624529109,0.12240225313244626,0.4604600517207188,-0.1503470147859455,0.3312489396917673,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06205307810286418,0.1673362922703761,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013387396551393684,0.08990405861028986,0.9881284412672939,-0.17552659496820483,0.17820407427848356,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0907112677394433,0.0847415335049889,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07108890030884772,0.057845965690205545,0.2199827255544769,-0.18488738990493053,0.0427095892872351,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.008944227636383938,-0.059856555052424806,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17722141188079413,0.20361656069948636,0.3847395636333395,-0.2233468349775,0.5777896587390883,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.12331281329916823,0.20797559976800006,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03744430832737215,0.09094395432186803,0.6808082741127099,-0.1414667793558968,0.21635539601064108,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03383368687780608,0.06723531913407763,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09208705440590229,0.13984573132867076,0.5106879183355835,-0.18302691096362952,0.36720101977543407,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09271769895570955,0.20734341984992907,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05416338794728867,0.04810370697652625,0.26100592599176475,-0.14879624838249994,0.040469472487922584,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.0480018658448037,-0.10397456298260205,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01717104236410577,0.08334485881437885,0.8369007542066076,-0.14679059152873108,0.18113267625694263,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05526296723550422,0.056881701913310594,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021755546072669295,0.06987936202903909,0.7557487073931577,-0.1592269454686166,0.115715853323278,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05417710731438022,0.05301662355545656,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07276202087650249,0.11901017850929264,0.5413653596515513,-0.16136283812314292,0.30688687987614793,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.024810217459188884,0.08081589067932567,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028754973511393812,0.0640462325138746,0.6537500678274412,-0.15475104665902428,0.09724109963623667,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07186766589465349,0.06517796935984671,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05862831726052452,0.0932893952589057,0.530145049723741,-0.1248968802035567,0.24215351472460572,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08720868654225462,0.11583524066128557,0.9458960226358858,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004215539077229779,0.08877464689685219,0.9621550889446169,-0.17042794056300897,0.1788590187174685,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08570142664360127,0.079517922741616,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03316154355437182,0.1332258665721544,0.8035854404929048,-0.22892937687791462,0.2952524639866583,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06655794099900551,0.12752507016474646,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012210455454759931,0.11565608076313331,0.9159840477553214,-0.23973690689190208,0.2153159959823822,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03305806132851718,0.026950161606464004,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059039011679867755,0.07109828428594109,0.4069283448044373,-0.08083033388424218,0.19890835724397768,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03973891452348428,0.09180360837936044,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027071617926601982,0.14176159619686315,0.8486712535543466,-0.3059546020283668,0.25181136617516287,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.030466423477274546,0.033246042559986345,0.9827611894425448,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03420479818887189,0.103804800981835,0.7419812785494893,-0.17000701543731056,0.23841661181505436,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07962649499626345,0.12066091346206277,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05792612072539727,0.08876501001229901,0.51448806200921,-0.23255064203563877,0.11669840058484424,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06565777760302749,0.022020062941245158,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032960786850375276,0.11961367575305612,0.7830603455992705,-0.2023513126766992,0.2682728863774497,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1120839588645742,0.160977044318495,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013247740731346797,0.12558209014514515,0.9915896697910755,-0.24572879324688313,0.2483783413931525,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.045877193678091725,-0.01994896818344703,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06257722770211338,0.126715532727492,0.6217515748138327,-0.3118605798027282,0.18670612439850143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.004285396863299831,-0.05904524641028335,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017920289452642155,0.13112168880661923,0.8913766788231026,-0.24003115040044623,0.27587172930573056,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.028858052019112186,0.07579735657510553,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055916982120147785,0.13119827962120928,0.6702418611111123,-0.20218513235498697,0.31401909659528254,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03236124816650382,0.09818123725444147,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09143703852347465,0.08084966449547878,0.2589068715709222,-0.2504899576710128,0.06761588062406351,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.03943536035479484,-0.09846361533632528,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0509018813790368,0.16306224328158844,0.7551167637094246,-0.2698851739356211,0.3716889366936947,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.49485844269613577,0.5309110585623947,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05676695589690646,0.09800774612119845,0.5628482499409688,-0.1360404999771887,0.24957441177100165,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07736021338001679,0.13863934853406112,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054360789607040605,0.09436565606336744,0.564968448311524,-0.13128170078313914,0.24000327999722035,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07882105893407408,0.1275843195766872,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04675648245459778,0.07588609972163005,0.5382319110148958,-0.19604474182791165,0.10253177691871611,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.025363848585414676,-0.016586535057442408,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0252453537560213,0.09032461566875857,0.7800415757189939,-0.15244732910970543,0.20293803662174803,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.08097798699906561,0.10042201977103118,0.9709847934855533,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05572326399910714,0.07358935678760883,0.44946557141277343,-0.20049321559134192,0.08904668759312766,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.029912610322173593,-0.025993987979222397,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04608675369530983,0.07589924351266887,0.5441344698836252,-0.19540087042185378,0.1032273630312341,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.031122666730645655,-0.012432176023235122,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031318218307084596,0.11041384366066047,0.7768633060451876,-0.1858953503343786,0.24853178694854777,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04005662126779167,0.08561121153923036,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0849906170260361,0.10700805202975396,0.42763056044730086,-0.12552284835236127,0.29550408240443343,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.043137464807391314,0.08617918444228138,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049493594789245345,0.09309643721008876,0.5953388795320289,-0.13365200257223972,0.2326391921507304,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.10541322340158779,0.15372826207313717,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.074572327067463,0.09021155873179541,0.40904672857805047,-0.25204259669293594,0.10289794255800996,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.015781512476466305,-0.051777637283178926,0.9256023179739352,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04981149450535626,0.15399476358378816,0.7465525798438581,-0.3527603915017837,0.25313740249107114,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07105720636986164,0.053739288264920596,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0523724248906565,0.09872419281660692,0.5961318104066496,-0.24658932308005896,0.14184447329874597,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05775236815582388,0.014691377094340331,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0026477513738547426,0.11852769304709448,0.982191466608525,-0.2358234323937553,0.23052792964604585,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03449228571289703,0.018710496963377017,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03991670900494048,0.12695434099066358,0.7534048364367003,-0.20983644283585898,0.2896698608457399,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.047743131035710616,0.1089213593898952,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061418831168630256,0.07403170596297383,0.40735579748411355,-0.08422133958979838,0.2070590019270589,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.09435025788863396,0.1477404185154737,0.9241469906913099,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1834161681534874,0.08947233219884188,0.04116632381266905,-0.3594321814290883,-0.007400154877886506,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,-0.01978142550959106,-0.17390340235610433,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031390065570198064,0.15751448906981896,0.8421650892675261,-0.3412632042025632,0.278483073062167,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04972775741174661,0.021380117461148915,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0763298796652578,0.1109711535656159,0.49204558792889896,-0.1419800666520578,0.2946398259825734,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06861794944485934,0.11647395344026405,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0021461251695576557,0.08047385718812237,0.978740374533183,-0.15616748046759044,0.16045973080670572,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.11722533527903732,0.10221062817085007,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07090428560391532,0.11967182320422609,0.5539336548149509,-0.16452220551534802,0.30633077672317865,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.062353944072080746,0.07057226876165305,0.9488833301512906,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014917464270737119,0.08416010273610236,0.8594212958704753,-0.18048290105350018,0.15064797251202594,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15642808654824683,0.1356042988937145,0.9839789607467108,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046391797739697996,0.11154613480045235,0.6777583947038146,-0.17304929048682005,0.265832885966216,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.04240326669354933,0.017713157373700168,0.9620942694833536,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030705100363190255,0.08715553327168887,0.7248391583656799,-0.14075314962741675,0.20216335035379723,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.1047086043437641,0.11898320888995939,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04642847913160564,0.10997708790810459,0.6731828518279022,-0.16992587410269433,0.2627828323659056,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.065349546597261,0.060080638804905516,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062322117454507144,0.09679436580851668,0.5201182781488274,-0.12809829473830003,0.2527425296473143,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0675143026743745,0.11405979350196876,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01557945287772921,0.06999041040427187,0.8239908182002916,-0.12211040838021323,0.15326931413567166,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.057257034580680995,0.051318468580546533,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07767640752211967,0.11672710907198403,0.5062313158858422,-0.15195704312244507,0.3073098581666844,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05251030797179643,0.10695450526369352,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05097531759868877,0.04848062672448984,0.29382729735842184,-0.04439904481518951,0.14634968001256704,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06473224289998294,0.09432287235111678,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0010918489183871852,0.08594958973014619,0.989872225152874,-0.17017768534603855,0.1679939875092642,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.07369719785956642,0.06280871115262696,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14103138082719574,0.1639284534862567,0.39024339977381806,-0.18145974169055584,0.4635225033449473,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06745825364854359,0.10970661668440468,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013876418906313023,0.06982722554275417,0.8426017039557105,-0.12349241407344122,0.15124525188606727,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.11355752105114755,0.11784451145671704,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013406476140421536,0.0863866072485526,0.8767663103491643,-0.18335204293869234,0.15653909065784927,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.03586572061082813,0.01001923629298648,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038936309152046454,0.08261436535222791,0.6377403840837892,-0.12358824867747792,0.20146086698157084,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.0941235260229319,0.11762192328793551,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010560130518937269,0.05386143149445676,0.8446845137729184,-0.09539971436251632,0.11651997540039086,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.06187269317439689,0.05026871051440748,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015367730401659278,0.0994424674554742,0.8772804650076893,-0.1802622061568495,0.21099766696016808,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.05903697675598961,0.06283178887503899,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015495506556830952,0.08302728491687525,0.8520656554216919,-0.14784137452152968,0.1788323876351916,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.024550211184570174,0.02869839363272792,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02889458627948706,0.08366189548854973,0.7300364787663556,-0.13569074356581134,0.1934799161247855,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.15456931347526115,0.19314851836763577,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05370359419530141,0.08103602149579721,0.5079828921383716,-0.21312312741711173,0.10571593902650891,323,9,332,4,log_other_mut_burden|lin_Head and Neck|lin_Lung|lin_Uterus,False,326,0.012355002807083655,-0.0652819675667755,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0549683087961736,0.04546534014596129,0.22789820745071343,-0.03461349547612085,0.14455011306846804,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05126592895060643,0.09293721146763649,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06781757074345096,0.04729038520444155,0.1529113484715718,-0.02536017779522373,0.16099531928212565,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08054859278882454,0.09393565461572828,0.769695804798565,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018833279290508622,0.030454091817342304,0.5369134831842963,-0.04117138544340261,0.07883794402441986,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11253448993992496,0.1131869562180604,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042190928951942076,0.05547500431341542,0.4477111550963032,-0.06711323466928881,0.15149509257317298,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.033690908523249234,-0.05611506180234521,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03993850297839738,0.03399873527027597,0.24132729591554375,-0.02705028537575649,0.10692729133255124,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.017119733464298875,0.018361451467432503,0.8487082760058587,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0492775642948383,0.033945683268663346,0.14795903203692085,-0.017606694014902433,0.11616182260457904,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.13595359666124474,0.21225501001758515,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05154323376463628,0.04431330658733331,0.24597204743215886,-0.03576868218321563,0.1388551497124882,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02790150611702262,0.023201631845236204,0.8552269457897888,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0009486895567885124,0.030156653193329098,0.9749309981627781,-0.05846992240563063,0.060367301519207654,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11752313363811577,0.1049173734022963,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016928430949927697,0.02603004107580987,0.5161203672197616,-0.03435938604136608,0.06821624794122147,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.027915262044266927,-0.0009458807045465339,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045404279282892465,0.04680143624628234,0.3329922603465125,-0.046810077588011936,0.13761863615379688,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02979387502467823,-0.0565852825476873,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01799103181951163,0.02979906624293995,0.5466082964141086,-0.04072301521284764,0.07670507885187089,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02561484356049953,0.03455702567222856,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05952649978512803,0.0524778562052943,0.2578426322478634,-0.04387228768946397,0.16292528725972003,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.08406168423358708,-0.059005375520059675,0.8664830381179188,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007347615236633569,0.03332459889311951,0.8256880842106118,-0.05831290079408915,0.07300813126735628,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.033992962111868086,0.008549255732158733,0.980597249022118,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014024544581739963,0.024934896649025415,0.5743596364326029,-0.03510547454913654,0.06315456371261646,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.016541175431126414,0.004826914762999854,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09864677107990456,0.07159660547331725,0.16959993967668385,-0.04242229554273082,0.23971583770253996,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05065656087375026,0.28359838470897614,0.7842677313995,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10548251937768299,0.06566087694340038,0.10954170596598059,-0.023891192724928595,0.23485623148029458,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.3203177028801584,0.48337036443414677,0.6985162532376802,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0117769367780903,0.02256188631751146,0.6021840155881482,-0.05623133825447755,0.032677464698296944,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.009974904760311558,-0.03637834562203696,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011819921274627273,0.03380363516668025,0.7269106731451191,-0.05478445514644291,0.07842429769569746,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.045364217504471,0.019534907147136335,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007107410662185223,0.02706029224186622,0.7930547598273069,-0.046210342936041905,0.060425164260412355,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.006575962942787717,-0.01764556192494319,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004378324586011995,0.028377518255851334,0.8775175666403368,-0.051534801280152975,0.06029145045217696,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04623598049676403,0.015427920771057467,0.9858833377512005,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05268102848245911,0.04375348870837733,0.22981108361250774,-0.03352786051123901,0.13888991747615723,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.009902913497955067,0.02321750616725202,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050918285957045145,0.044507503340051775,0.25379702095159096,-0.03677626202295457,0.13861283393704488,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09642081688025353,0.08920748491164349,0.8634493629908433,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013771910947493799,0.0334931193411421,0.6813188178950602,-0.07976446817140179,0.052220646276414186,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.13208642128880166,0.08502410458501737,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0780615531325062,0.06459763143775361,0.2281238184576603,-0.04921721256753883,0.20534031883255124,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.012030320225477623,0.05013861048940525,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007868085969353974,0.0296594062508474,0.7910303748307811,-0.06630695648183811,0.05057078454313016,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08269812062843858,0.011092650930619018,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026752011702373624,0.028308886304315425,0.34564849461240155,-0.02902588644901835,0.0825299098537656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.027855005400581313,0.06613369889645863,0.9073272983575541,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00734754799026055,0.02847466899724465,0.7966082837157833,-0.04875699706846879,0.06345209304898988,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10351182939738054,0.06324283932048719,0.9738068609884574,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0357605810069908,0.027795208845968932,0.199536437293406,-0.019005202127006474,0.09052636414098808,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.016746220317831184,0.08636831164162455,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01232543721200155,0.02831954443980355,0.6638056170051025,-0.04347346100238653,0.06812433542638963,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.048114319374855996,0.014018824937954295,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036391543346368536,0.030331369647291547,0.2314518956499342,-0.02337131799660657,0.09615440468934364,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017557424273252055,0.009112442463281535,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0029173410093427006,0.02599522935271794,0.9107420851332975,-0.04830188533786063,0.05413656735654604,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.013668007808735462,-0.032344968895243235,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04743388793936592,0.041904602744934294,0.2588344926389012,-0.03513208229540019,0.12999985817413204,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07451862631913875,0.041665242860165534,0.8664830381179188,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06407614870793468,0.052262705861781035,0.22143756541055165,-0.03889872120880232,0.1670510186246717,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.022237507867751374,0.041566167760676835,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000957568280886078,0.02882980299992574,0.9735323192869297,-0.05584670858709576,0.05776184514886792,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0393249083128056,-0.011425329098106824,0.998018743752871,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018453106652479352,0.04004236383310357,0.645349143767086,-0.060443635084879606,0.09734984838983832,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.018345155422753775,-0.02725426194133001,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038177619650344795,0.02756634484544844,0.16741395262449854,-0.09249246477235797,0.016137225471668376,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.14235898656022508,0.02008626927019633,0.7842677313995,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001447101372689923,0.03350251546731229,0.9655845122655885,-0.06456396933715687,0.06745817208253672,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.037849837078625784,0.043293308886111666,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03220761700478249,0.02490639811115633,0.19725780273211677,-0.08128148456100368,0.016866250551438706,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08832993048015671,0.014653743413085438,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024034191349055257,0.02849095116306932,0.39978464724498397,-0.03210243497833615,0.08017081767644665,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.013602513922006454,0.030417885966993075,0.921525791075194,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018286079972501056,0.02346671202043565,0.4366424116838107,-0.027951128335632645,0.06452328828063475,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.018575716346097018,0.028903285049968527,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03393046398795613,0.03011400742553376,0.2610293037379937,-0.025404121663180193,0.09326504963909245,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04070471405044266,0.05742343373441309,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015530110875477487,0.028766375163417242,0.5898088086819143,-0.041149192110921634,0.07220941386187661,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.012336870831899797,-0.014429834998704419,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017161967920389973,0.024731829124515863,0.48843118484818326,-0.03156794081482527,0.06589187665560522,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.028857187137978312,0.01397220616131504,0.9404802865694325,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007853447527683913,0.023647439641226568,0.740111961940087,-0.03873985415400233,0.05444674920937016,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.013236091591079354,-0.016565162032086418,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006848025801289067,0.01886235890308898,0.7168991297797163,-0.04401313086694174,0.030317079264363608,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.014999378346477823,-0.03317497798073978,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012394256123922478,0.022687020062988745,0.5853790763062896,-0.05709521259493239,0.032306700347087436,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.03701055726011266,0.009424198361421336,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010841289977208063,0.02516116610880646,0.6669635800132846,-0.060417135014012684,0.03873455505959656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.021601017159556757,-0.022369173837208538,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022979582616925162,0.02163586319523645,0.28930144605981045,-0.0196502460788573,0.06560941131270762,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.00595926192788981,0.014388865235406473,0.8780447660402404,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012360959767646767,0.02220268869813187,0.5782514676244328,-0.03138570322639252,0.05610762276168604,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017877022579193862,0.003047604625413624,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032009426633257225,0.02511059037681942,0.20368823947587666,-0.017466767431856746,0.0814856206983712,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02792490199185313,0.03634809433409313,0.8179445630780711,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12220070171725991,0.040048488777899065,0.002545942811590354,-0.20110951162795898,-0.04329189180656083,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.4265201841445645,0.005181005361375644,0.07655187135759178,0.7315829080671686 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0869136503674201,0.036886804051787125,0.019301775792396753,0.01423440832965428,0.15959289240518593,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07964087899606268,0.1695617976612132,0.3170765275914746,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047925031332528734,0.05055112769590075,0.3440986802537802,-0.05167746174153243,0.1475275244065899,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05328967965006322,0.12281086338194562,0.9053547642872083,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026238056159205377,0.03145192909366513,0.40501853391094444,-0.03573267906480185,0.0882087913832126,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06285263642607242,0.07418102844592275,0.9237532919369174,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025358468288172762,0.02889362946543486,0.3810500119406752,-0.03157156789277747,0.082288504469123,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03389751967882046,0.013215652490714923,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033112786204904272,0.03750163919746383,0.9297175313559418,-0.07057939264012773,0.07720194988110858,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.027266464143950436,-0.09493128664672716,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05202752925934285,0.035326336172632256,0.1421804919818045,-0.017577073334950753,0.12163213185363644,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02688984661146658,0.09392905933798888,0.7607934302264618,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015309885000156516,0.044212920091308935,0.7294516633987557,-0.10242400624528394,0.07180423624497093,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.015834903883347684,-0.11229857423658761,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042320787539941396,0.03463446178541677,0.22298604828833057,-0.025920592966107103,0.1105621680459899,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.026015416208646933,0.025779217340288593,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021743473372910112,0.027131341345227288,0.4237183906377324,-0.07520121727695217,0.03171427053113195,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0036212208086452346,-0.07667292785277323,0.9288749656602147,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00924528437713622,0.025473221492196437,0.7169820477600121,-0.040945413296582855,0.05943598205085529,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.055800529439733536,0.08585032218818286,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048352239789502614,0.032323753457977694,0.13605754793052996,-0.015336278680224004,0.11204075825922924,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.013186585703059169,0.007852201105101196,0.7473242853882033,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04966233272473593,0.03432428011859669,0.1492984046370996,-0.01796788698768989,0.11729255243716175,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.03667124208973999,0.04633040422604163,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011024477810514632,0.03990869392807264,0.7826098690425594,-0.06760888986583138,0.08965784548686065,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11819732439872763,0.012016061603057963,0.9718034799423088,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06820008549230419,0.03650076140241872,0.06296984707730265,-0.00371852444757223,0.1401186954321806,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10672243232379518,0.1403471760612893,0.5817074626033015,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010520255573386431,0.031226845754607845,0.7365011551225369,-0.05100699079604164,0.07204750194281449,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.12078589545378823,0.07057721730013451,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04939136326330818,0.035104201363707684,0.1607793293319946,-0.019775560059011203,0.11855828658562756,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05378652708703109,0.049636515482108394,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018138778423621472,0.033331571139726936,0.586836436111634,-0.047535475246122956,0.08381303209336591,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.077382307628409,0.13955561416756035,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01453822003277429,0.029230379682962944,0.6194055567293767,-0.043055325801428436,0.07213176586697702,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11740643533855058,0.07456951384799537,0.9576211468940484,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03070955524289286,0.030711160574977196,0.31838665246183995,-0.02980162023210246,0.09122073071788818,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1361665512327761,0.1561342894870795,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008951291143556812,0.02039482849754768,0.6611459826209107,-0.031233287455634057,0.04913586974274768,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.056454206330853435,-0.06905070772688421,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029436468127781477,0.024045869861047866,0.2221368817405739,-0.07681480953101415,0.01794187327545119,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017686297773271433,-0.07822413032995129,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011141209247678733,0.022098263364958487,0.6146268274029908,-0.032399701194474315,0.054682119689831776,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05409868288796307,0.006766435463054423,0.9557595790374268,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023756939572392277,0.05627789587050768,0.6733198986662638,-0.08712918679427088,0.13464306593905545,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.01240262171936701,-0.00271839151614083,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0035533763640868523,0.028007465808474127,0.8991521821461463,-0.058737376135406735,0.051630623407233026,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.15666984893104965,0.1213280128310128,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03726694720372416,0.04386503815710003,0.39644097481460994,-0.04916173121308348,0.1236956256205318,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.09605592747818545,-0.06564321411189347,0.9212557438608796,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022319711696272778,0.02302512307687739,0.3333821612038357,-0.02304741988564161,0.06768684327818716,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0020340570753792104,0.005117635649591896,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019425915614087595,0.025536497334812273,0.4476083652660461,-0.06974128769099333,0.03088945646281814,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07470805518305289,-0.10050235537547224,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0041589471608474175,0.027206665525517235,0.8786387527340637,-0.05776510469061057,0.049447210368915744,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.027650460244181725,-0.03422834988982452,0.986191362849829,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009033594551929456,0.022152192297577086,0.6838021509162477,-0.03461357377966076,0.05268076288351968,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.005324683172916868,-0.032577753875234094,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005308806015158551,0.027500639419484108,0.8470956471735864,-0.0488765776184006,0.059494189648717694,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03515592636546657,-0.05747146098988928,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005164418852057205,0.017429079386286385,0.7672603644767021,-0.03950548774577101,0.0291766500416566,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.011599208472595067,-0.04265058448634044,0.9686101294099047,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014893065873547383,0.024767344682970125,0.9521028282662771,-0.050289192755837986,0.04731057958112851,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.009758863595189293,-0.03498997182314113,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02144239714532661,0.020470256560776626,0.29597297517131327,-0.06177559405409398,0.018890799763440765,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.014260470958433,-0.06853843188509401,0.8833721946393759,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0031514832757183918,0.025795436553353455,0.9028693815211306,-0.04767408497082576,0.05397705152226254,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04775993781295779,0.02448963749844422,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015562524159948809,0.024988236500444797,0.5340368980733734,-0.06479764049485863,0.033672592174961005,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.005882817507713343,-0.026917797476136922,0.9464658142652354,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02768506446348029,0.03654955321821333,0.4495457132504401,-0.04432968154133196,0.09969981046829254,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04319596700714968,-0.07933653509153034,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02031177453301997,0.03462257655818685,0.5580056196273389,-0.04790618813218485,0.08852973719822478,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06340348152902431,0.025708936100854816,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016660930164621,0.02951060524212815,0.572913513571472,-0.04148475299248838,0.07480661332173039,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.010771193995502793,-0.01816514269631215,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014353930911273259,0.026212637633702143,0.5845004501435989,-0.03729366187972612,0.06600152370227264,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05182621027344743,0.09821252034461168,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016436388808126177,0.03362140627022494,0.625401838588032,-0.04980893622824947,0.08268171384450182,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.00751624946601316,-0.041458465129667894,0.9596829295789286,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004444380273506782,0.023335790219642445,0.8491218612188612,-0.04153486865070982,0.05042362919772339,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.0118984347851077,-0.030757219569006254,0.9828627793326524,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018384623120566927,0.029839058686988502,0.5384205737555187,-0.04040822229499209,0.07717746853612595,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.009303920012706274,0.016322539363258233,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003323216611639487,0.02620579431575439,0.8991997660147979,-0.05495732579585179,0.04831089257257282,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.028503421131978544,0.0011698866027879228,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01478785627970726,0.0345911284460952,0.6694120213708978,-0.05336814317103389,0.08294385573044841,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.024042354467473753,-0.04958842862414022,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027433188870099306,0.027314263230156864,0.31626349013405125,-0.08125134957604527,0.02638497183584666,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09942026549733227,0.0901626396299068,0.9025176929330414,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02824666690264156,0.02703608986455282,0.29722316339280197,-0.025023399982576213,0.08151673378785933,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0858871954831661,0.1517192548662831,0.8843360296870468,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01999548730988347,0.02958013104598117,0.49973439834385447,-0.038287184747619926,0.07827815936738687,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017694464102195735,-0.042991496603767346,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020585734489131934,0.02665465271121883,0.44072193605169896,-0.03193277465336472,0.07310424363162858,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.01046351118796273,-0.01849594770513646,0.9320838159679753,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012882633928841166,0.02598801895094721,0.6205692826135774,-0.06408765339233756,0.03832238553465523,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09558197806571071,0.0468142505196049,0.9580596405456464,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0063474344606186004,0.023978254332111783,0.7914651016625055,-0.05359255083882178,0.04089768191758458,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03238352033980098,-0.04380121840981913,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04651741899518313,0.024360573106254557,0.05743711060965288,-0.0014809922112326984,0.09451583020159895,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04538794211986861,0.019963242385632976,0.5608066224101164,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002581570658598894,0.02878649244338922,0.928619608657574,-0.054137370043720864,0.059300511360918656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08529961245113053,0.024906500817467935,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07617231994942326,0.04265374004285677,0.07544424867359956,-0.00786969930598408,0.1602143392048306,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1447394070671882,0.2611686264228228,0.6286648421036044,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01227915165857129,0.027451019204523926,0.6550712595265549,-0.04180846368885513,0.06636676700599771,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07462460307732918,0.016448957031327933,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05751121109829769,0.03921181946524192,0.14382893166460414,-0.019749082681949755,0.13477150487854514,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1604243798468195,0.24492771421077159,0.7626680424539931,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005708113715584691,0.02790300159337337,0.8380891009144288,-0.06068628432472143,0.04927005689355205,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0940663235565737,0.014625282030312305,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06909027404541818,0.04098209057905958,0.09317786282608247,-0.011658041157693227,0.14983858924852958,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.19749904903542537,0.27338240173236167,0.6699741992153797,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008680338500729842,0.02118023887265711,0.6823106844338145,-0.05041243611705782,0.033051759115598135,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02496186193732358,-0.01649387805407424,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013649257882203666,0.020543916899295148,0.5071036194950174,-0.054127590096384195,0.026829074331976868,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06293374680829279,-0.005227032441497958,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016248008365698806,0.02115401767348889,0.44322666695778845,-0.05792844152017229,0.02543242478877468,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.030557466792859037,-0.0015820938333291094,0.9330352189956562,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004895508720984525,0.02467772953291687,0.8429248770387063,-0.04372780586998208,0.053518823311951125,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.012640289765509391,-0.02294808134412334,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057372861633468414,0.03943422896677956,0.14706033819095773,-0.020325652654336654,0.1350713759212735,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.018329069071741064,0.06286133038323838,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034200655006096155,0.03404895995621537,0.316214823376119,-0.10128840265475911,0.032887092642566805,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.062258477306679695,-0.03303357375104121,0.9025176929330414,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0050962620551213405,0.01986534077492783,0.7977629288201368,-0.044237574170875864,0.03404505006063318,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09172296807746215,0.06209132646604154,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023362917147256496,0.027752518635384936,0.4007572766234482,-0.03131875210841938,0.07804458640293238,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.004804686848662507,0.001821041149213321,0.922090220822299,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005928416770949665,0.024164413608939016,0.8064145267028009,-0.04168349514527591,0.05354032868717524,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09717671293580564,0.039176212626735624,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03649448971406888,0.029503490981783093,0.21736528516728215,-0.021637175989839295,0.09462615541797706,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.009810574076775895,0.007096367827855249,0.8311395152494632,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009612738053548528,0.029034882144035577,0.7408888913314257,-0.047595612768108746,0.0668210888752058,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07971982258661217,0.01799734945735991,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02649543954057298,0.029563505330680574,0.37107169788652816,-0.031754474341820244,0.08474535342296621,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.009795630107326632,-0.005129723674087124,0.915340937794674,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05259971373657159,0.03457467145189227,0.12954897312092156,-0.015523859975598936,0.12072328744874211,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06551789737340802,0.1576742118341338,0.7324499634144411,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014613342234676124,0.042970117949289975,0.7341055302390338,-0.07005204646213846,0.09927873093149071,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.022765572254972603,-0.043837022067301994,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01828244704603815,0.03233482219344053,0.5723457366267393,-0.04542788050486085,0.08199277459693716,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10542633085607116,0.06907640482296484,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059314019806243554,0.06406297928112865,0.35548376301963824,-0.06691130376195391,0.185539343374441,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02103622046644876,-0.0016622871261566382,0.9108386596575023,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06372626198948894,0.03798560929638432,0.0947753089328684,-0.011117990934346789,0.13857051491332467,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08038487771082885,0.10970697676910471,0.6729775750805861,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0020833888430823854,0.03991270316456873,0.9584157230277843,-0.0807246560454832,0.07655787835931843,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.00736426523487737,-0.04998627564409998,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011635306182828476,0.026790493382587103,0.6644724740192329,-0.06442146651622489,0.04115085415056795,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.09410754144832988,0.03540061562842421,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008069624393740836,0.031621519898112814,0.7988012614013966,-0.054235260980724745,0.07037450976820642,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1361715678729157,0.14097341026294463,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005209563079519402,0.021285684706039875,0.8068721593112554,-0.04714942397172078,0.036730297812681986,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04255311857745075,-0.09281590671672345,0.9742852449973755,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02808383277284448,0.032305831891521856,0.3855830105570405,-0.09173703981075632,0.035569374265067365,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1662524136806432,0.026423366359041665,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037911783622351126,0.053376400520198576,0.47825477713393083,-0.06725743426559141,0.14308100151029368,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.02385208676015465,-0.028446009923389543,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007556223239584768,0.024239059628630995,0.7555224430061782,-0.05531521258015788,0.040202766100988344,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.08194374290603296,0.05694423777997381,0.9654221498691481,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015683608711135385,0.020749759944530707,0.45051535403655985,-0.02520030259538023,0.056567520017651,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.0003887701084415337,0.0016604228320889747,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01592540355592322,0.026524847524882062,0.5488337011918631,-0.06818815341544479,0.03633734630359835,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.037940712333135375,-0.013188498589657227,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008580068716671652,0.02294046550971507,0.7087380211463703,-0.03662025937081474,0.053780396804158054,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,3.7385985133505515e-05,-0.019063589481754694,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033238194613805696,0.027349541908130586,0.9033765070265289,-0.05056385194469611,0.057211490867457256,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04623845723949467,0.024806759787276565,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019057375775248537,0.021386312884879917,0.3738059376855196,-0.06119550756550515,0.023080756015008076,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.006766348679736066,-0.01163778635636299,0.915824547329523,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00292144686585934,0.02325519012654875,0.9001380491499873,-0.048741886865724594,0.04289899313400592,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.0007938805130454892,-0.019501033405402452,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027231089912925464,0.03826080910688649,0.47735770312315184,-0.048155397941541646,0.10261757776739258,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.023587540243789187,-0.012725736315501484,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0580420689872432,0.03218398533664463,0.07262687250940264,-0.00537105991213007,0.12145519788661646,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.013285477529620376,0.03092543193056962,0.6232563394374466,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0035871736364184144,0.022075715310280127,0.8710594389595734,-0.039909309657176345,0.04708365693001318,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06924229457969518,0.04355940768191363,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042515766098632016,0.040908168644182834,0.2997576159159825,-0.038086898367449856,0.12311843056471389,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0829630509548442,0.02918997159540242,0.8872020712681092,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012787227489470789,0.027526113039892,0.6426939249802754,-0.041448347627758356,0.06702280260669993,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.04817240554911532,0.026387810284759457,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.064344712904479,0.03443107947849508,0.06292216959019625,-0.0034959369801199347,0.13218536278907794,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06846676091797184,0.14990812855683935,0.5817074626033015,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017374820054213095,0.029798033607981608,0.5604065906658642,-0.04133719234467756,0.07608683245310376,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.008054726625344389,-0.00910779008807582,0.9509421797147564,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006976281660967065,0.04304727264503329,0.8714001416699111,-0.07784112738432786,0.09179369070626198,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.24367566993648612,0.14788197261473354,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00968852010437142,0.03991125016427523,0.8084141665687453,-0.06894988420538455,0.08832692441412739,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.16891410422435868,0.07953355587496935,0.974516576191754,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023691595449805272,0.03593588090612986,0.5103793060344342,-0.04711401250013046,0.094497203399741,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.07366136607307451,0.02716618576903221,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009166412595775667,0.04067800098015335,0.8219142674646107,-0.07098274520868868,0.08931557040024,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.02179535399170427,-0.045925467841161124,0.9793038292216457,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01297003961608401,0.03131772360610547,0.6791547837960341,-0.07467634550380471,0.0487362662716367,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1414971888837611,0.06149428221603626,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06370697422068372,0.07735737673752141,0.41105350141080055,-0.08871272306237654,0.21612667150374398,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.3276727251283103,0.11286544708301069,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006311599613447861,0.027591479334081535,0.8192651211600015,-0.06067596801701981,0.04805276879012409,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.015117657297099182,-0.06394607416944462,0.9784383200536336,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011182573516285026,0.026383943741127267,0.6720785409441608,-0.06316769617370001,0.04080254914112995,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.015339907675015071,-0.06547763480869272,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027923628641601264,0.03401116465639602,0.4124886759744587,-0.03908964972694723,0.09493690701014976,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.17584262541385354,0.15788704794229227,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007087472267727103,0.024717746238742993,0.7745724614511642,-0.055789633045644674,0.04161468851019047,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.037470671744266826,-0.027575694816707005,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03576110772478624,0.03237208590694503,0.2704483983780293,-0.028022641704820862,0.09954485715439335,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0995947231648087,0.10027166501076243,0.870012817074135,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030477586508376325,0.03382494145724385,0.36851017924241936,-0.03616877037396192,0.09712394339071458,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.14519201192698494,0.13528050734384478,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047222309333192644,0.02309173324968266,0.04199455736799574,-0.09272068505500852,-0.0017239336113767656,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.012285113302457495,-0.09400893122878069,0.4909466809825482,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02868653976690297,0.025585179638387714,0.2633647501763094,-0.07909783213333957,0.021724752599533624,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.005645728017443351,-0.07172206795300469,0.8670850705749964,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049020177444194186,0.027560543362750663,0.07662030039938779,-0.005283236832127454,0.10332359172051583,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.034736365840893915,0.005772097036385324,0.6296189902384475,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02482685185640218,0.03479458702246619,0.47624354633733046,-0.04373002849190781,0.09338373220471217,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.127722747349198,0.13791152778428284,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047046096123078696,0.04556780467788655,0.3029496974938146,-0.04273759727210173,0.13682978951825914,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.052854813674651835,0.04341858458041458,0.8910021114138201,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037928216747156844,0.03472306554490514,0.2758413980267583,-0.030487742561443106,0.1063441760557568,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.12876548334049465,0.127573195077167,0.8716406527156833,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008757521345904361,0.04147444764509478,0.8329535874757512,-0.07296090062821213,0.09047594332002086,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1622751059765691,0.06272416851792383,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025906541420579975,0.04158276389296058,0.5338942030736158,-0.05602529949826833,0.10783838233942829,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.10766191219137917,0.061045001149995254,0.9464658142652354,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008457619155250663,0.02895582803358963,0.7704834472231746,-0.04859496884078705,0.06551020715128839,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.012517021380513063,9.140941070013568e-05,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05636747518795784,0.05672181384611529,0.3213874331221241,-0.055393316870772445,0.1681282672466881,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1802006348523323,0.2407501938984257,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0304814646815507,0.037947275620005806,0.42265477050136735,-0.04428725818173003,0.10525018754483144,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.04450455635247246,-0.04267048323342717,0.9288749656602147,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02076245548597575,0.019794948136993316,0.2953358671572245,-0.05976507075060333,0.018240159778651833,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.017444349036563316,-0.027286743257804294,0.8830041858734644,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030634241453177006,0.0277946387282056,0.27154249494692906,-0.024130418359676675,0.08539890126603068,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.10544725421049515,-2.7099356703262806e-05,0.870012817074135,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03442082960365617,0.023710003259331085,0.1479357674876096,-0.08113740236994471,0.012295743162632385,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.1168941735258386,0.02086117689409045,0.7662201971017615,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042085609905837894,0.03381288618167421,0.21452283890917737,-0.024536994084009923,0.10870821389568572,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.14307812511658294,0.0186237537922721,0.8289622204693651,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04138901913225279,0.02892282381887197,0.153782965223911,-0.09837657787538034,0.015598539610874769,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.12462089739430492,0.029409832435672596,0.7711789647234355,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00933712333090499,0.024095628322627585,0.6987423683090546,-0.038139258750167424,0.05681350541197741,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07699003793460557,-0.019753508769120378,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02665318889409243,0.020718671897979466,0.19958528471061832,-0.06747584643471911,0.014169468646534258,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.0845596811129878,0.012634002801494282,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010330699290762068,0.023627192898680382,0.6623492329059426,-0.03622270959078013,0.056884108172304264,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.05381181943671176,-0.03840320411253018,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007501650801358226,0.021087120165658484,0.9716524466653712,-0.04079845778910657,0.04229878794937822,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.05340819656309137,0.034317870096177795,0.9975397208522654,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011322261120709816,0.025326980535830924,0.6552643575696184,-0.06122481559154795,0.03858029335012832,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.057041196718226085,-0.08285146836489515,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006182104443192023,0.01880336903307956,0.74262384060413,-0.04323097989366384,0.030866771007279793,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.03646028621186311,0.015018819403336535,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01789751691216576,0.02146703771308721,0.40530330880632126,-0.024399669571999762,0.060194703396331276,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.07908338815902588,-0.030276035984242267,0.9237532919369174,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03213784506888045,0.0299302701045479,0.28405671179676334,-0.09111040723854211,0.026834717100781204,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.13494486486214013,-0.03672487438778231,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007326795910335946,0.03198576934055617,0.8190225414381336,-0.07034937353464499,0.0556957817139731,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03368477723589157,0.00812029437508787,0.9783899072890752,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005335352731613258,0.022403377461553332,0.8119771874338766,-0.038806733709534386,0.0494774391727609,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.022715797000319126,0.024252372565007983,0.9761434066106486,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010576267478718993,0.02851663962822729,0.9704469645375244,-0.05512961437862689,0.05724486787437069,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.08813519219231597,-0.037419099226833286,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00309381016554092,0.025632271961421323,0.9040341902035539,-0.047410269701246066,0.05359789003232791,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.06180352140911186,0.0612751866463044,0.9884605236688444,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014100599096465001,0.02511432015266528,0.575033003608399,-0.06358414205743526,0.03538294386450525,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.021427290982532488,-0.020006467484949577,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02362525093124244,0.022427011765895368,0.293250103028926,-0.06781390479317442,0.020563402930689544,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.007768333231592063,-0.05004199602043663,0.8803348634474737,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017569895172824104,0.02941901525808053,0.5509418461768296,-0.0403953253286026,0.07553511567425081,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,-0.03258115613233368,0.02536284680500907,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004066309967039593,0.024595131809337107,0.8688295725352271,-0.04439425970475771,0.05252687963883689,97,146,243,11,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Soft Tissue|lin_Thyroid,False,230,0.11329722463105547,0.06969739120833296,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09546927612162073,0.10092889590347358,0.34493072156989313,-0.29405910466258667,0.10312055241934523,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12923164934595743,0.050228384137207524,0.906393006043464,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04059335117936526,0.07763803266151266,0.6014481829686682,-0.1933555849924975,0.11216888263376697,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05685673754001431,0.005634813549724719,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11175291142760783,0.06336960416278942,0.07879646580426511,-0.23644028378757953,0.012934460932363875,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.03879310005064079,-0.06677455090839877,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11025846399880812,0.09951749344113897,0.26874795669013285,-0.30607118722728366,0.08555425922966745,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1568934713502917,0.053392499440001344,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09826237338066839,0.09167753957713529,0.2846292093368163,-0.2786490377021824,0.08212429094084563,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1668494009684544,0.04268418105736287,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07742726616299357,0.11782898265922487,0.5115925585097776,-0.30927006255928896,0.15441553023330185,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05730302205707268,-0.0201516246207485,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10275336819237357,0.10764950514852549,0.3405629271668318,-0.3145668095125987,0.10906007312785154,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1323775658171265,0.00997565965783418,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025162815143034308,0.05563659844152368,0.6513891234623315,-0.13463456202186352,0.0843089317357949,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1435170588064605,0.10643438516262055,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07852805819406296,0.03939876587973724,0.04711731965255123,-0.15604990256522883,-0.0010062138228971035,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09389814898117815,0.0027832669366609467,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11632971203161314,0.10761299112737258,0.28053436286836686,-0.3280713075921558,0.0954118835289295,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14641418625843253,0.02338760838297753,0.876035315676277,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07010054662807091,0.046550147336894374,0.133104075170484,-0.16169360028667534,0.021492507030533528,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11671476929277134,0.06326100570714993,0.7419804415051278,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11409219415541887,0.10289839436060556,0.2683796429259045,-0.31655724948265224,0.08837286117181452,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14121423709907682,0.011400259616973805,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10475083449177007,0.08801218838312114,0.23488119850808784,-0.2779254763429516,0.06842380735941149,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11578778076128464,0.019529131071344102,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022774617103720224,0.07695993490300346,0.767482391003927,-0.174202611436762,0.12865337722932155,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10990241411514658,0.0724990938575187,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19998581452704606,0.1416797078328466,0.1590866924473023,-0.47875780181964483,0.07878617276555272,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.028858116005231763,-0.2267277148549439,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1908788635845705,0.10119819326145624,0.06020116022672062,-0.3899985672982468,0.008240840129105725,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.03588272282074763,-0.24129807189551056,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02381887690268818,0.06517585158902908,0.7150198074225556,-0.15206025987050953,0.10442250606513316,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04909566598197427,0.0037899776455083798,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0768909976687649,0.04027331630416517,0.05715259142267557,-0.15613362593717733,0.0023516305996475334,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1337286264114878,0.0690137043239798,0.5594047727659663,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04044093919676231,0.06797975735508612,0.5523450412489113,-0.1741993464056774,0.0933174680121528,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08364007755622077,0.036376906557609834,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050731509638534907,0.04671026548876021,0.27828068199515965,-0.14263961515657653,0.04117659587950672,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08546210035884239,0.05202959053723022,0.874155937347676,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09444535059856497,0.11745338678927186,0.42194811717661174,-0.32554911662355823,0.13665841542642826,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06541443905896749,-0.02816727536335487,0.9283326369589645,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1198172941159716,0.07969008102897007,0.13371440134946208,-0.27661718166348015,0.03698259343153694,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10762525935785432,-0.005051632567915175,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07090933168055825,0.040989696457626255,0.08463477111785354,-0.15156152467840206,0.00974286131728555,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.016622010319932903,-0.09199589231783337,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12868671649869382,0.07400028830029268,0.08302376004781592,-0.27429124762912305,0.016917814631735445,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1483799846160593,0.003947053661823463,0.6473895945575272,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08008060266082113,0.05828230120870654,0.17042728982748304,-0.19475809021680682,0.03459688489516455,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0910648930166232,0.006736031434113634,0.7844207095472905,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002656630156621082,0.04561445837290112,0.9535940922992192,-0.09240860243547075,0.08709534212222858,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14566140215174533,0.14265222526435326,0.994341785733425,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0934859610730823,0.039901760486512165,0.01976437955020438,-0.1719975082624777,-0.014974413883686893,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0275210349592465,-0.059135929878569096,0.32215532827417326,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02675698672052356,0.053273439469506925,0.6158417953121926,-0.07806495862360263,0.13157893206464974,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.163517094235625,0.19704568595096994,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048404458177894745,0.06471507852695245,0.45504792754702417,-0.17573921433111575,0.07893029797532627,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07098014804620437,0.025723341598968417,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007291654986733625,0.05589043072633232,0.8962841641997479,-0.10267953766000054,0.11726284763346778,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1351242059236907,0.13007244417970412,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033222278539388465,0.08841639531500503,0.7073604571044967,-0.14074768941319682,0.20719224649197376,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1167904473092783,0.13890475809644715,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09452818005444935,0.130694530046788,0.4700541240332018,-0.3516854993820701,0.1626291392731714,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07223728951984527,-0.05171095503906392,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12076935766345598,0.06827864757060843,0.07791209402300116,-0.25511586757697136,0.013577152250059371,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10663542071020478,-0.036546153296467904,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05030723309737745,0.08072346332853853,0.5336068342577648,-0.20914042549630174,0.10852595930154685,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.054174950955259045,0.008124428234748416,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17238669476591034,0.11294437247928993,0.1279521462621559,-0.39461842894420174,0.049845039412381026,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08930455729379361,-0.08372817654956927,0.7288842902994255,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01417738868443585,0.04089077197352481,0.7290409302695209,-0.0662801584078885,0.09463493577676022,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13838554634278372,0.12570180372839093,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11978569387609542,0.10932275043846089,0.2740548301184693,-0.334891447990003,0.09532006023781214,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11036615274327717,-0.013878645678517678,0.8705271074351378,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002334662370116563,0.03679510980287851,0.9494486607156855,-0.07473349802059331,0.07006417328036019,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.18486911747417942,0.16767319328695549,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028377390382369607,0.034544726670026775,0.41200897464007635,-0.09634832462261081,0.03959354385787159,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0640391458457385,0.024581803486344384,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04932063200857644,0.0423580612129074,0.24516483253549026,-0.1326652484169832,0.03402398439983032,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11571425048363318,0.04657562894431066,0.8535607195906675,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06320366445073453,0.05358711240265426,0.23911794146804194,-0.16864279928706766,0.042235470385598606,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0605795210400333,-0.0158467517829829,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033549729377182376,0.07110442556467886,0.6373736985429409,-0.17345629978986313,0.10635684103549839,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09510842373872065,0.04719978051321227,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06571288659186507,0.054824957250610346,0.23159822391081133,-0.17358763111079115,0.04216185792706101,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08201196088862463,-0.0026634878054108916,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003555838547851624,0.07597318485208027,0.9626995900891284,-0.15304228262740566,0.1459306055317024,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13382498122305791,0.11175578568507248,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0570483964641009,0.045680677631229655,0.21265849730235092,-0.14693066315506964,0.03283387022686786,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06621040212644458,0.005165318012592461,0.8287104327864808,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0071923078742780295,0.05717148214054444,0.8999696524277082,-0.10529950860791207,0.11968412435646814,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.066027607430276,0.054343517832340794,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04271040976967581,0.08186006799369754,0.6022164667880217,-0.2037800095279817,0.1183591899886301,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09251570590522136,0.031153290131299877,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03493679818431092,0.041199577935282734,0.3970961274769592,-0.11600195841308121,0.04612836204445937,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0429094833260004,-0.0034940676305670482,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0071284232691434905,0.056527210535670704,0.8997294629948172,-0.11835255732599474,0.10409571078770775,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07005261580604157,0.03662985436820801,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0075373922123054,0.0708235859827691,0.9153138622103616,-0.14689137672855154,0.13181659230394074,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09648081719713371,0.07872555872466556,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03518430196392091,0.03763670383078225,0.35059596343552135,-0.1092390758093656,0.03887047188152377,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.08123324922321123,-0.12944848911842413,0.9088510667694087,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0048810886138657816,0.042362830560873435,0.9083442934185815,-0.07847291206439104,0.0882350892921226,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.20669217670614223,0.18660806762485524,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.182736641061633,0.12363472579485477,0.14041001472747136,-0.42600294034614294,0.0605296582228769,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04633339608061066,-0.14489816098883312,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11732776493254454,0.045100511590253384,0.009726342783223407,-0.20606848466046163,-0.02858704520462746,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12480846337389004,0.030160907528278918,0.199353905835858,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0211067817040111,0.0585772610219809,0.7188495883984862,-0.13636463842207155,0.09415107501404935,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12728635321040008,0.09717019527134399,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053322427962626276,0.1634121129628421,0.744411972154192,-0.26821069894133015,0.3748555548665827,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.20427113089810478,0.23049372372072194,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04794412923283774,0.06929176113053533,0.48950585278776915,-0.18428406279730464,0.08839580433162915,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08441763763917923,0.02416153753426189,0.9415307631280134,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08361986587151812,0.07598786208184877,0.2719927241494151,-0.23313518917854306,0.06589545743550682,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.17251145211897603,0.10597681205697868,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08975440972433289,0.06383711378041146,0.16072508506461894,-0.2153616638879618,0.035852844439296,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10768640812694649,0.0019595410387838,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010704910780653729,0.1256447386987814,0.9321573442076991,-0.236516332371841,0.25792615393314844,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1033073176625768,0.11246636347762706,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018024246323023695,0.03637643259050313,0.6206025033617679,-0.05355079119634941,0.0895992838423968,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09837361965579203,0.09461701796257074,0.9580596405456464,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11366295471163478,0.046248107079774226,0.014529187889918329,-0.2046617075772203,-0.022664201846049267,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0017859330274702433,-0.11154237001695025,0.262949343295113,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05190973363528446,0.07940053260832301,0.5137427053282588,-0.20813989959121232,0.10432043232064342,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09303585355132608,0.0030283250364842463,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09855357552309946,0.07048506163060062,0.16304351611816906,-0.23724147236988,0.04013432132368108,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09909834583303091,0.005552413771720624,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14234004686430018,0.08679263719842265,0.10201590547857886,-0.31311507403132,0.028434980302719653,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0648978728151251,-0.09777077897553371,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09626743241169365,0.04342970186704011,0.027371827776785058,-0.18172063161848231,-0.010814233204904988,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12509264313798418,0.027664168344774392,0.3921977777836097,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15377713651768338,0.08729176003759706,0.07911172225705589,-0.3255342483311787,0.017979975295811995,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08430925140285324,-0.08636178846960066,0.6349735604413647,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007712447538670549,0.07286248854411874,0.9157701154582644,-0.151078219823381,0.13565332474603992,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.17506810900153144,0.15993060874985648,0.9897049933979173,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07259748782241204,0.07882865178515547,0.3577887612979419,-0.22770240898494273,0.08250743334011865,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12500811005652404,0.0363792944459643,0.9120511198404183,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06968114303173599,0.055176090822952856,0.20757598334059044,-0.1782467853882166,0.03888449932474462,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1132249756072583,0.02144971296875189,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001509030764455565,0.08266874292596625,0.9854479722067597,-0.1641697964094686,0.16115173488055745,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12453791946650002,0.1097067219807108,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017801097470258483,0.08537655569941278,0.8349742857983864,-0.1857898127533422,0.15018761781282522,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1483891549644122,0.11657475454618149,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02074881304325176,0.07052728911428045,0.7688047544636932,-0.1595197975793271,0.11802217149282357,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0903485768284634,0.05323157546408507,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12409308825027773,0.11094321702870698,0.2642047913240911,-0.3423873066729706,0.09420113017241516,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12412687604841346,0.0263616285489014,0.8687894090847701,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03421775122149774,0.04223531049498379,0.4184623683851372,-0.11732084072318945,0.048885338280193966,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08223095153678124,0.015646232069560045,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0681006264695203,0.11360228286494428,0.5492991046530168,-0.291626879026447,0.1554256260874064,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1397521225986836,0.05797258805942634,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03168370124489401,0.07019783820678815,0.6520528346694856,-0.1698064512130005,0.1064390487232125,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08696207006028034,0.03424019093231163,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02041480435639492,0.0871070152787204,0.8148561209601924,-0.19180840847805697,0.15097879976526712,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1258218258846469,0.09133996231365388,0.9770888048613304,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021091782097863485,0.0894637694582221,0.8137757867903356,-0.1971225855491215,0.1549390213533945,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08071586342490517,0.04603555400064057,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05472898872011782,0.05747055265090789,0.34168630761093244,-0.16780926265884782,0.05835128521861217,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05573118450984886,-0.005450423025613715,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044428748470747965,0.09663796879894716,0.6460210400569735,-0.2345756581593701,0.14571816121787418,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11192126365208081,0.06899937538367791,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05885032929772549,0.08287743423283042,0.4781812261413081,-0.10422106177301083,0.2219217203684618,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06566421573646962,0.09024635006101045,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024140581081796,0.08870097794685451,0.7856819918938536,-0.15038933767138832,0.19867049983498034,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08652514714306737,0.09688473382785873,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003449435473050394,0.08067395807327969,0.9965911783196788,-0.15839084126516223,0.15908072835977233,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06275926701949297,0.038155932798649726,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0667335720811054,0.04472406777076007,0.13668197364811904,-0.15473359299428485,0.021266448832074028,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07927338901323715,0.014076439110322988,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05957113729492807,0.055684104549045405,0.28553664723897,-0.16913635819487816,0.04999408360502202,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09840337714360921,0.039427391496859386,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0500671442784375,0.13441481747746797,0.7097874704941223,-0.31454457977663874,0.21441029121976374,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.047799699864506585,-0.027458940283700838,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0355690685650669,0.0465034775429534,0.4449295450852133,-0.127070293750826,0.055932156620692224,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10278993159995767,0.08093634926790488,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07046547281646615,0.0977571681458175,0.4715607893727013,-0.2628145427923732,0.12188359715944092,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12842871954015553,0.05113883849936185,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011767680075552681,0.04716486928746495,0.8031380090735749,-0.10457027363520718,0.08103491348410183,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04125203156157188,0.014610388541397555,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09464742557146621,0.09159256353155368,0.30224173813696104,-0.274866889229869,0.08557203808693659,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10043343285753749,0.007604876760207836,0.8904632102898862,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002136659033839086,0.08342068062305076,0.9795823944344207,-0.1662769531825654,0.16200363511488725,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10660223349554278,0.0882330772129221,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08756524837376678,0.053595233275625556,0.10330740071386409,-0.19302036201137912,0.01788986526384556,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09550973693432983,0.021891856411950676,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0427497053106746,0.08317458930747892,0.6076340777730416,-0.20640578498615858,0.12090637436480939,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12728938657639627,0.07391943792699163,0.9536178942986169,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09526166140591975,0.07321000371781472,0.1941494037396953,-0.2393112118905391,0.04878788907869959,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12380415794049127,0.036036937105692494,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05628438145389922,0.04500214996069218,0.21198251864599535,-0.1448315627607852,0.03226279985298677,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11022738897695293,0.061561292440262344,0.8272946081671145,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07108956650248499,0.044737636565792924,0.11306906176268867,-0.15911628566352456,0.016937152658554583,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06616588007575414,0.01122160321090762,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002686497597926999,0.10417501577686494,0.9979440462081607,-0.20524561236488972,0.2047083128453043,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1375228929624456,0.13232714337560772,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06439536860757045,0.040954184622914745,0.116880183568106,-0.1449776877689534,0.0161869505538125,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10303281221691554,0.04438511746005626,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03426394856502987,0.043871070589562966,0.43538797641956983,-0.120585594197835,0.05205769706777526,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09065805536238189,0.05026705414337188,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001853991656031301,0.08453665890597753,0.9825168887389203,-0.16819010825855543,0.1644821249464928,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1293473121132695,0.10438755991690103,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06255570612666132,0.02924443760224749,0.03320900720837142,0.00501373266881603,0.12009767958450662,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0413181148819161,0.09983826374768848,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030188801128689137,0.046814434042850975,0.5194926815842184,-0.12230187089518574,0.06192426863780747,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09366791394377186,0.04026927758123963,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0144532463781445,0.0769719049954895,0.8511770453110563,-0.16590479331812943,0.13699830056184045,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.01543954939629259,-0.02585298759107363,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035939896944915346,0.068443613019185,0.5998862280631609,-0.17061099636131533,0.09873120247148465,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1113297041626192,0.0621626536794602,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07916093546472684,0.07772046148675685,0.3092159128203581,-0.23208535797640317,0.07376348704694947,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.016065365558510184,-0.04170229877714984,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045874445845579204,0.06361784359119407,0.4713933858299021,-0.07930136765984144,0.17105025935099985,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.094683309795432,0.10669811021110481,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05704427539621834,0.07920037562296921,0.4719104646518286,-0.21288060823778512,0.09879205744534844,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.0011137193603686008,-0.039552913509117646,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029001790851424777,0.05648435082704611,0.6080023655851177,-0.1401415932398189,0.08213801153696935,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04374330883297448,-0.01962516985238917,0.9536302663534211,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04291217368795568,0.06687715027862345,0.5215687151943393,-0.08867672053557818,0.17450106791148956,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05722659372859844,0.0674097230279974,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05359697443366481,0.05663396509367829,0.34469201196085364,-0.16503116101492857,0.05783721214759895,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0873667014192829,0.020078795476564104,0.9063150682163816,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014375241294106637,0.08011390128415395,0.8577129651281379,-0.14325856394422504,0.17200904653243831,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.11779040348214798,0.11288291523834536,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12400270200922751,0.11030400793740248,0.2617992320972895,-0.34103919911526803,0.09303379509681302,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12986138591210597,-0.0008650234850692828,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026316367017429076,0.0609616804918584,0.6662680035138361,-0.14626585787508795,0.0936331238402298,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1496861969581016,0.12108488025995151,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013692880910828053,0.02862486278061592,0.6327327877059166,-0.07001576585596646,0.04263000403431036,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0727210273559292,0.04102848169770157,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04599634630902527,0.053403860669931386,0.38974050402710925,-0.15107491116333782,0.05908221854528729,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1114552631389375,0.06994356025958788,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03425739730140781,0.06420441683841134,0.5940218447473313,-0.16058736472428536,0.09207257012146974,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.14991881970253115,0.08746974065900363,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08227297466651483,0.07375038039738131,0.26547175709980286,-0.22738578172579538,0.06283983239276573,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13549856576446304,0.06266045744461159,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013726071372336116,0.06901369080831711,0.8424794500126013,-0.14951886789426108,0.12206672514958886,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0863935283011174,0.04983224789635513,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09107333159077498,0.0740711862910749,0.21979956547624058,-0.2368173631061763,0.05467069992462635,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12847170499300514,0.02897723823566652,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0957025221852074,0.05576009109063378,0.08709806282403057,-0.20541725581023365,0.014012211439818845,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05719293805740391,-0.03991401566221164,0.6570209000268399,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05691005593538216,0.08732410464642032,0.5150691108209172,-0.22873080968474668,0.11491069781398237,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.17313275635072717,0.10672907994266065,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10798122974495152,0.0413819392851639,0.009509193352945271,-0.18940520801964628,-0.02655725147025674,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1272089105028098,0.019659090522171088,0.1989347711166319,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10303352835573698,0.11805024549327418,0.3834488139677167,-0.33531168618032314,0.12924462946884915,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10999695606441635,-0.0037462067863688825,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12931186295644764,0.11795304599006372,0.2737959205127003,-0.36139876898436996,0.10277504307147467,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09213195918378983,-0.04194583820292192,0.870270919138952,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036618856013848726,0.0902086169062665,0.6850693393685641,-0.2141152370449683,0.14087752501727083,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13426313889759206,0.10605400471996673,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03231879522014816,0.0750208134752725,0.6669138754878003,-0.17993133325193902,0.1152937428116427,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12911981695849786,0.0797277886236834,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11522790403395469,0.03931583950219038,0.0036310575812478854,-0.1925865807121508,-0.03786922735575858,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.01459217439024656,-0.11994478429972975,0.10149061647868209,0.9699148959817107 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09905447389171755,0.1501301683325216,0.5098765223111031,-0.1963448180662135,0.39445376584964864,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.15511510770179754,0.16239969662184295,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09980537119059153,0.06661578377458027,0.13508933321173403,-0.23087999515723162,0.03126925277604854,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08317565867067353,-0.028550283539366825,0.7471520865805139,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10937351845883968,0.08007361176765443,0.17295348129107646,-0.2669280491930562,0.04818101227537684,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1798183283611763,0.07423938896212327,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04495797374579039,0.043826494129443706,0.30577494019386964,-0.1311919097936169,0.0412759623020361,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.06533108283415603,-0.12142662161545749,0.8944539216937829,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018255383350456213,0.06492185334867677,0.7787515744174316,-0.14599699401273766,0.10948622731182525,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0658435064179348,0.028698409784871124,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02427530009570285,0.03907290773929932,0.534869097979175,-0.10115597910328311,0.052605378911877415,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09042150315902928,0.07082309052385626,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005595575972775898,0.09258142209080494,0.951844410098323,-0.17656958668466072,0.18776073863021253,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.05501808571727316,0.041227473084549354,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05010754173941352,0.034572057802356615,0.14824318529513084,-0.1181322532932241,0.01791716981439706,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09948615647652233,0.05523765083646736,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024800098481968402,0.05700897739268184,0.6638489522991908,-0.13697216718800143,0.08737197022406461,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1069977448965126,0.05069788995390283,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004462949662823381,0.07749888241779532,0.954114365605046,-0.14802548919006586,0.1569513885157126,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10920974445751887,0.09101756744779081,0.9945843511717473,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047866474343281236,0.08570606232072558,0.5769077531844196,-0.21650353381802442,0.12077058513146197,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13526117708479996,0.09458402478652365,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08198284446095594,0.059197476452017804,0.16707435731050943,-0.1984610501663598,0.034495361244447895,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07177692680326765,-0.025451876703165097,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04262992853464412,0.04186327153116247,0.3093205742650636,-0.12500098630870754,0.03974112923941932,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.061975344665682074,0.010019281372975346,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11423576871320541,0.07833085862461375,0.14574633271878154,-0.26836122153303876,0.03988968410662795,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09553093065239564,-0.0186075273534533,0.7646625175952992,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05207002340456992,0.07442246318179187,0.4846659778173549,-0.19850523475378815,0.0943651879446483,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1156217219801443,0.05483158887932917,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08549768736116085,0.046001363133058706,0.06402981298426635,-0.17601094162267344,0.005015566900351751,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07482223418646694,-0.01673650807317746,0.5879399282333936,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044093972962903794,0.09666885123925455,0.6486118054045802,-0.14611370166791524,0.23430164759372282,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.15584185024999866,0.1887328280368183,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1439079526558908,0.09222563402495045,0.11968474382160565,-0.32537305919597387,0.037557153884192285,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.005654424406476265,-0.13837224000643902,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1556297754431654,0.08046037026693778,0.053990379934774395,-0.31394530037405777,0.002685749487726957,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06423323755811132,-0.11385041799140888,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13063382213536254,0.06024157845999029,0.030878496897730867,-0.24916642501698077,-0.012101219253744286,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07260800665970167,-0.04605552715812935,0.42002168600416523,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06451457940373456,0.06679385798101053,0.3348567391719671,-0.19593958594224362,0.06691042713477449,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10530300260023316,0.033280095738960715,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08662943624525823,0.06828500245875542,0.20551640132634164,-0.2209884501709914,0.04772957768047492,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,-0.01534559843621421,-0.09764278637744267,0.8193818150318936,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1563221652888649,0.21836842431517312,0.4746122644285953,-0.27334416124050964,0.5859884918182394,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.3818547239731472,0.5045992432216055,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03545048762718214,0.08306521727982712,0.6698356093661437,-0.19889136458966586,0.12799038933530157,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13828137765476822,0.09223249758812585,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024191996249178584,0.08099208073186719,0.7653716256123018,-0.18355372592766625,0.13516973342930907,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.137021336371545,0.09325188651977938,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08614103671298863,0.08228881910635187,0.2959985441082826,-0.24805425622148186,0.07577218279550461,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.036942268207738264,-0.06739710099405925,0.8833721946393759,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04164426687829572,0.0545876892079521,0.44610873975636656,-0.14905215778222916,0.06576362402563773,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.12807042546207056,0.07067647735917411,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05556788898925721,0.08678936672427737,0.5224740377021099,-0.22633648110223287,0.11520070312371844,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.040387525710111734,-0.038953445919359245,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05731903816369605,0.08763792061842847,0.5135669203048326,-0.22975726285155293,0.11511918652416084,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04122890690437634,-0.040134148684292444,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020241749351709408,0.08779958105341595,0.8178199249932349,-0.1929980605278672,0.15251456182444836,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0854647862139746,0.07035317508733424,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0024240475157417687,0.08375782228494694,0.9769300908674019,-0.16237961369184956,0.1672277087233331,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08727086220097774,0.05072057665601457,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041264388415668256,0.07705131875935871,0.5926563471024107,-0.19287219155571766,0.11034341472438114,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13864157171471594,0.08386840321325748,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10746347402553383,0.04320914735899742,0.013404648076196308,-0.19248270552125168,-0.022444242529815972,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.02844707154723918,-0.09010232878156893,0.2480344649940285,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1295965260287184,0.10878016041782525,0.23441999125742186,-0.3436346685513021,0.08444161649386525,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13410035058145248,-0.002226422005654859,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06917198287054235,0.05823872442244431,0.23584541272160311,-0.1837637278209569,0.04541976207987218,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08087542829200307,-0.002352847143364895,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08330353549706043,0.05815931678555378,0.15305273207759443,-0.19773903630298323,0.031131965308862364,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09880381791255705,-0.013488316873532774,0.7699192568009788,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13348278748237308,0.08778170033586698,0.12937072741704203,-0.3062039161808028,0.039238341216056655,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13162360180418461,-0.002174200715208291,0.7319635311735422,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025454148081678934,0.036261116457633004,0.4832240399493737,-0.0968022871410056,0.04589399097764772,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.13234757843142603,0.08826093224371083,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16895948148287968,0.03497221939056194,2.133806100958267e-06,-0.23777155943438055,-0.1001474035313788,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.00010669537495762708,-0.15510020853938492,0.00015979389461704454,0.0015271015592713227 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07567128058409942,0.11891311855406471,0.5250113526624733,-0.3096472456784578,0.158304684510259,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1202506283609523,0.01945754703881438,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0218348127768156,0.08348635163394102,0.793851146020685,-0.14243469704078401,0.1861043225944152,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0837957721450356,0.07220700874955428,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013067414228281426,0.05977336099013634,0.8270925627678039,-0.1045439140646689,0.13067874252123174,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10619484001268892,0.10104645993705881,0.980914908860308,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08416970666151424,0.08982381031073197,0.34945818723067545,-0.09256952077999586,0.26090893410302435,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07889531550857463,0.09819904121432504,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028932052490144855,0.04367423686062429,0.5081726848139471,-0.057002298937853024,0.11486640391814273,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1081098025630004,0.12541759987425014,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14582490146593668,0.0751857971306207,0.053341225310108854,-0.0021122618927674475,0.29376206482464085,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06169162278457256,0.13457583989126545,0.5414611847974988,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007368482088909038,0.06511332510640264,0.9099735756965055,-0.12074987245030518,0.13548683662812325,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1059196442134206,0.09826391826088438,0.9890962952045544,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0692478876931039,0.08394602571668441,0.4100551369953147,-0.09592608656413489,0.2344218619503427,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08645651118043185,0.10095395727367468,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015962513327083587,0.07523530088891339,0.8321150586706341,-0.16399708132678253,0.13207205467261535,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08622792324817065,0.05540564269940329,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03936572102097669,0.04811301738804889,0.41387358589724765,-0.05530246877889119,0.13403391082084457,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.0648775701563233,0.0759015450895672,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0049537513361067155,0.07861230999303732,0.9497950745573182,-0.14972549114423492,0.15963299381644833,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09893990938400347,0.08017155039144533,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03907660993182083,0.029532478454186075,0.18674946392165823,-0.01903211879355443,0.09718533865719609,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06531004412561943,0.07947179315491783,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015301380726286628,0.05784437607164983,0.7915493292996628,-0.12911719752779338,0.09851443607522012,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.08564195112403496,0.05674814716234127,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12673053435056053,0.13094123702838487,0.33387492604212454,-0.13091221084778454,0.3843732795489056,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.10132108633002475,0.13639564537332413,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01658820613432186,0.05481424478847016,0.7623773354523864,-0.09126546031770746,0.12444187258635117,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.07601165500570056,0.08514103971661674,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014235982378301888,0.045796236242486646,0.7561192065395099,-0.10434562463491545,0.07587365987831168,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.04981907024973005,0.012953637174591323,0.9654293488033827,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006771651703478134,0.06282287797993716,0.9142321123965319,-0.11683997066498147,0.13038327407193775,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.09690978856145963,0.09088212542925395,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027288041257634656,0.03432044806000197,0.42716419639580705,-0.040241597649773135,0.09481768016504244,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.059465097685510074,0.05243453054217575,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03040854292135764,0.05802340816182908,0.6006005581875283,-0.08375954120432584,0.1445766270470411,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.06440480445907211,0.07810362769999488,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02780212040865121,0.07369874912635045,0.7062525033807818,-0.11720909587060954,0.17281333668791196,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.048349294436412824,0.055481982393839835,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09936888739361935,0.0793328599701067,0.21130820373303486,-0.25546589923644614,0.05672812444920747,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.1928914336041499,0.08867997167122882,0.8262879414940053,1.0 +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020238350938848296,0.05144965610434247,0.6943214921665899,-0.08099507971340747,0.12147178159110406,308,9,317,4,log_other_mut_burden|lin_Breast|lin_Lung|lin_Uterus,False,311,0.01175750236968849,0.007457969629466383,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04025269936354357,0.08970756139681933,0.6541313954270045,-0.13665217960484144,0.21715757833192856,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16570732182700684,0.26310885776697857,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24066559838452176,0.0905748219286364,0.008524971229179203,0.062050466489557976,0.41928073027948554,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15848102405279632,0.40432603873395767,0.18849922456051393,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09946484881719075,0.05666734222851556,0.08076460593229323,-0.012284140479836711,0.21121383811421823,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07023288833503358,0.16908671748174714,0.6398297823258919,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18432678878153316,0.1268675530362463,0.14783247402981847,-0.06585824317596325,0.4345118207390296,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.25490754085327455,0.4626236281100312,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15156378454082514,0.08614795527043978,0.08006379243191813,-0.018321488932134755,0.32144905801378504,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22350117007054776,0.3123959235606816,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15792904576134767,0.09247022404720658,0.0892239070710599,-0.024423852238959876,0.3402819437616552,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08424770521902626,0.23743966048349208,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17942061660438785,0.06905005241784325,0.01006988139852632,0.04325270639105433,0.31558852681772137,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22807250714672858,0.38510595737411724,0.20399134085447534,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09896674123282147,0.049906594676063995,0.048745405010495284,0.0005500642724512311,0.19738341819319172,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1631345177126951,0.22239738718906482,0.5228932769909616,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03707703435334134,0.04768698190967879,0.43778680401328296,-0.05696252743769402,0.1311165961443767,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14094339430522979,0.15005729791563507,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18789804920852404,0.11361392518744581,0.09974667714307481,-0.03615059698643175,0.41194669540347983,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.248105083951432,0.434029423762415,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.191869409441335,0.047551182557500925,7.795443462424631e-05,0.0980976463462729,0.2856411725363971,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15513554202334962,0.3793801839426617,0.003916470266121944,0.037428512926404645 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21154399691314757,0.10321752341475292,0.04173204671309696,0.007997236720525464,0.4150907571057697,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2446789277280487,0.4364067620843861,0.49032550277088105,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11324058265899774,0.11846062985822049,0.34027109133189004,-0.12036584985662489,0.34684701517462035,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15888383156174343,0.28886057132806303,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05037833164365223,0.07002143168760103,0.4726996061987714,-0.08770515546724915,0.1884618187545536,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17382346028630413,0.20201996886024634,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058362861378056075,0.15210754258409695,0.7016164128734848,-0.35832159386425877,0.24159587110814662,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.029212699441850908,-0.02669464472938219,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-3.175094101095458e-05,0.09112155876326254,0.9997223311483812,-0.17972505742963304,0.17966155554761112,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.025469660494695987,-0.06149300632108512,0.9998482883527592,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0763375573011655,0.07200125088211243,0.29033364258583994,-0.0656501678642634,0.21832528246659438,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11132042122146948,0.1527793034649076,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10053115206684622,0.059354927019027524,0.09188931247191086,-0.016517801410231375,0.21758010554392382,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17507721062716228,0.2964948814795188,0.6673534880164945,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08595382316724264,0.05463409018630277,0.11725433748015406,-0.021785557565699734,0.19369320390018502,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13221778073012364,0.2118315001154618,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0845825234325091,0.0755943387573271,0.26453828192797646,-0.06449083382223617,0.23365588068725437,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12252786726722965,0.24043156540124794,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12404049922759323,0.086076601595565,0.15115073652554925,-0.045704063551405924,0.2937850620065924,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14102063641401655,0.2547514236246882,0.7686319965021204,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11288738842789094,0.08467379303895346,0.1839969454702752,-0.05409081135941533,0.2798655882151972,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17368427805271847,0.32227837638881957,0.8036298987262369,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04816478705001548,0.07493639799228524,0.5211349626255942,-0.09961109951668784,0.1959406736167188,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.025490384809305967,0.05321439363039736,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13879760371049268,0.10125811552556664,0.172010776831012,-0.06088516987844847,0.3384803772994338,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2599814451532205,0.3919471950607346,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10217524673869602,0.08833995416516514,0.24882356702937536,-0.07203268686605488,0.2763831803434469,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15224124044806128,0.24207963089426449,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1070846274525433,0.043805923462896294,0.015379318826237623,0.020698580751057877,0.19347067415402872,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17117836598020023,0.26966947920677425,0.27154254286073387,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06410995480559742,0.07892203986822661,0.4175835831138026,-0.09152568720084897,0.2197455968120438,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07611237299015634,0.1402214244187453,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09642681958498238,0.038070377963712536,0.012089177172496206,0.02135136885279887,0.1715022703171659,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15208389400268643,0.24639714909311744,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07680477201668193,0.060329215821040935,0.20447734075904087,-0.042165496006423955,0.1957750400397878,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1276938522283789,0.20734406335628902,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07367045044380524,0.06115304422491707,0.22976103685732324,-0.04692442159048038,0.19426532247809086,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16240542227581276,0.21129382012260725,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09177757005460054,0.07398140002832783,0.21624027315489885,-0.05411504383588299,0.23767018394508405,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19715474442513187,0.2771045971978484,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17055176344826087,0.0758433863949883,0.025630840839982686,0.020987279899234462,0.32011624699728725,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17959578282784963,0.3258154656352149,0.3753830527449863,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11553495339085325,0.09521235528859029,0.2264052935338867,-0.07222547534397734,0.30329538212568385,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21043388525101528,0.314649075490529,0.8421767666691623,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033526300399972675,0.07564203561444134,0.6580882360478519,-0.11564111589063963,0.18269371669058498,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09412875662576528,0.13009667397077046,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15556030308576857,0.13453409248426038,0.24895616932455697,-0.1097432786577146,0.42086388482925174,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1713741922103353,0.33240185236323067,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1405923812077032,0.051073205008069,0.006458906344159338,0.03987512828279749,0.24130963413260892,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.137780167514939,0.25010817251237144,0.1553660562422328,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001933798046539768,0.08202864402482808,0.9812156198965005,-0.15982812165343616,0.16369571774651567,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1474283290630325,0.13098216262694665,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06319404720636747,0.09721003877879622,0.5163957708077391,-0.12850584828632944,0.25489394269906435,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12388732655809687,0.15994235915003246,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12429325455012799,0.06340621617299089,0.05136720016814372,-0.000744911946324256,0.24933142104658024,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11276889995384003,0.21073386450446252,0.5316325649082267,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039661038108274906,0.059808854072328214,0.508018649778639,-0.07828306745157329,0.1576051436681231,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17411508339694223,0.18379854703091167,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14708805117740278,0.05031173465285144,0.0038639110834294732,0.04787243110183849,0.2463036712529671,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10994440222750934,0.22118084919656114,0.10548035157916945,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06192153484944437,0.08326693063994096,0.4579691815807122,-0.10228230769810193,0.22612537739699068,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15889684395586895,0.20298689014171356,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023376015021888873,0.05597045050796095,0.6766561458703267,-0.08699869162204715,0.13375072166582488,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13637573298282354,0.13602292681701245,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.091220438797997,0.06432850651157741,0.1577507955178166,-0.03563650036578521,0.21807737796177923,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2030264165183122,0.2637259827206786,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06520238853988895,0.04558316278331601,0.15417697844246325,-0.02468840516375778,0.1550931822435357,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09118787917963539,0.14597712097773766,0.7721494352531693,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012208078030909621,0.033135525848942075,0.712947224215033,-0.07755191414224022,0.05313575808042098,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12978331229425222,0.09995213305244274,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07207164856422592,0.07574855211798724,0.3425313661176915,-0.07730582013305666,0.2214491172615085,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16483127032961817,0.20736114281689128,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001986839737554531,0.02930907300252774,0.94602181622532,-0.05581116448253974,0.0597848439576488,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08428406947045716,0.07162781286005376,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017422450179995767,0.06647878880112416,0.7935358189327071,-0.14851978360104087,0.11367488324104932,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09285449990974494,0.03790943727987533,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011337632694069283,0.04909890603528354,0.8176199191049719,-0.08548626815003398,0.10816153353817255,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16002037478961162,0.16341811629612138,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09685057837579526,0.03316337252669829,0.0039012401080264353,0.031451828129229795,0.16224932862236074,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.00917386663267094,0.09356485905532942,0.10605494512847206,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04316954162336111,0.04743267913495128,0.36386457644089987,-0.050368530651249944,0.13670761389797217,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20208525032129682,0.1960951536752066,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.191098460239719,0.07337117812455124,0.009897482538290984,0.04640921460883998,0.33578770587059803,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14498851735241564,0.3424625432710978,0.20196970794075533,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1581607014590427,0.08502287034123288,0.06433829660433264,-0.009505884869473652,0.3258272877875591,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09702704212249746,0.27268170791957513,0.5880149074273526,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06943668083562296,0.045015960333374024,0.12455120007277895,-0.019335579723267965,0.15820894139451389,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17126592764644707,0.2217855232474731,0.7259506085296737,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18043781256116875,0.1544047515864278,0.24396879644335154,-0.12405105622786777,0.4849266813502053,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.32304246207270004,0.4744991602506879,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09996817119259062,0.06923211020090159,0.15033158132454533,-0.03655876015090963,0.23649510253609085,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15105553018995513,0.2336172881700233,0.7680634195565342,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13768088742750068,0.11183031010948451,0.21972379974564488,-0.08285043865998734,0.35821221351498866,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23342996485610715,0.41050481306819114,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07783170821631902,0.06539298678099997,0.23538702499818648,-0.05112440464357382,0.20678782107621185,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1817545621994673,0.234636353459896,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09427562872472661,0.11182431993822385,0.40020709036521707,-0.12624388464034017,0.3147951420897934,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17405470741658144,0.26331372200696,0.9218931756584715,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07289328030038113,0.03232820608044892,0.02524117851484482,0.009141492882719857,0.1366450677180424,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13652421556770378,0.16625221843736562,0.37388200177512143,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11410606453855858,0.08832402816406477,0.1978966815278538,-0.06007046271367038,0.2882825917907875,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05089380369828489,0.155853492867229,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03576031297088724,0.0847745417928084,0.6736078741225784,-0.13141656511989094,0.20293719106166544,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19822773138629138,0.18996060610730875,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.128227003750117,0.06418474205848702,0.04710920393938412,0.0016535706005202655,0.25480043689971377,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.160438646502679,0.2916555099626582,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10640205876578132,0.07497289200861648,0.15741098114596652,-0.041445794638963585,0.2542499121705262,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10501566576911744,0.17618644945409484,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11784922758069184,0.08408631654264066,0.16262215284319745,-0.047970458288068965,0.28366891344945266,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15591586645363772,0.2553617068696501,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10798703782425097,0.060920074380352476,0.07783233868143413,-0.012148413604745043,0.22812248925324696,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1280442907445396,0.19419772125415916,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12341861392434109,0.053708969168952486,0.022611423598813584,0.017503588006724954,0.2293336398419572,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1886200477568547,0.2903767881319269,0.35125142960348776,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11020424311888748,0.07978410177619309,0.16874947386090405,-0.04713140003704365,0.2675398862748186,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1596883679391635,0.2150222869628316,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1983064714822543,0.1253668325231476,0.1152890690672421,-0.0489191133940676,0.4455320563585762,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16261335201566982,0.3288523741378972,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11753465732740982,0.08016020407140664,0.14416737026953133,-0.040542666128135854,0.2756119807829555,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16466208877023977,0.26045208330937086,0.7634426852565308,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08445838994445634,0.08674231251226523,0.3314084156355541,-0.08659896639746051,0.2555157462863732,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18784817718964336,0.25170940415926196,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11392795362782543,0.07247623092861358,0.11756212411675868,-0.02899644049092609,0.25685234774657695,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14005688156726845,0.23343489547426977,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1985017264389988,0.11877486615987254,0.09625332289122258,-0.03572438555565155,0.43272783843364915,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21489479913425236,0.4589638197304066,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06519812859897847,0.027962024131959504,0.02072377190439244,0.01005652829514117,0.12033972890281577,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14176045173041735,0.16118738255089787,0.33233394217589335,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12032077899545424,0.09384768637064402,0.20131169129085788,-0.06474849878172961,0.3053900567726381,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23886967621223862,0.3490221243870886,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06519330569689041,0.057893952349352594,0.26149405690385613,-0.04897458019691561,0.17936119159069644,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14146782567099797,0.1739807706885004,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07181027533879975,0.06884612031859264,0.2981947605641354,-0.0639554772105202,0.20757602788811969,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18061636588583543,0.23140574766226965,0.8855940007795015,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057913469166859924,0.0739875436504963,0.43471132719363914,-0.08799126005391704,0.20381819838763687,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.154154036320415,0.1925263223304533,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09237403577698045,0.06103545876403872,0.13176029366142533,-0.02798895567331393,0.21273702722727483,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09023359674458178,0.17253236830621818,0.737305253544566,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12648684735193527,0.07230939272448118,0.08179811655727488,-0.016108538912296744,0.2690822336161673,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17024284758494299,0.30929450214315785,0.6428846031996515,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06485755910557513,0.10831725433441466,0.550007994299516,-0.14874595959286985,0.27846107780402013,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1379437879749,0.15168123023601982,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09050241150935806,0.08433060706912132,0.28449395408553324,-0.07579901954729185,0.25680384256600797,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13720290714272676,0.20092148739280366,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004143706181547784,0.029796607885384473,0.8895390443299722,-0.06290313771168923,0.05461572534859367,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11883443767372613,0.0814088175491926,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09459162542775208,0.07260314626913397,0.19413626723338084,-0.048583047960710904,0.23776629881621508,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13395519029822428,0.22506339114995214,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06954375605765174,0.0666869952333497,0.29829475608914563,-0.061964164086739534,0.201051676202043,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10619973465895112,0.16528323432892864,0.8855940007795015,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06840523070053586,0.11596628921938654,0.5559492167566744,-0.16028231847963484,0.2970927798807066,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12651031190946968,0.15452896519123924,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07594079127830253,0.0634854497553291,0.233052080640938,-0.04925362522735208,0.20113520778395713,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1477227120283784,0.25520094704771384,0.8443484327374559,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11384032157785567,0.08774638947405991,0.1960103964347151,-0.05919709208181062,0.28687773523752197,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1821676906050233,0.2770861455710032,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03945954078668485,0.05447019308586868,0.46966031387033214,-0.14687571357300488,0.0679566319996352,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08533879473726806,0.02658340910669079,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10800382082292598,0.07709974848449239,0.1628294927316558,-0.044038230725090416,0.26004587237094234,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17982426370108956,0.29491313452550744,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07154495078104295,0.11075089740535145,0.5190281070910249,-0.14685775458809874,0.28994765615018464,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1615829539447795,0.20301680913382195,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12651503849847523,0.06130770661667867,0.04035919638823715,0.005615169524472136,0.24741490747247832,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1412356351865526,0.2869163284687134,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06378600064165056,0.08525068507957667,0.4552171581770792,-0.10432984033258792,0.23190184161588906,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14572005084628648,0.180248855249528,0.9339658313801124,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12119812371115714,0.09642236758670011,0.2102523673470376,-0.06894847042393996,0.3113447178462542,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19819470216872884,0.33891476836474416,0.8251393055567431,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11565176665710003,0.04163192035149724,0.005996232709715275,0.03355289208815883,0.19775064122604125,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0907733571660717,0.20952864007810307,0.14874404765537455,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08011761276054384,0.035582765384437914,0.0254468039985646,0.009947777512769346,0.15028744800831834,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07493696889678735,0.16778910439483002,0.3742940281840044,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10916248202359922,0.10739731897793896,0.31066230057966,-0.10262690807339832,0.3209518721205968,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19321064906765295,0.29137740740469703,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.108464497056792,0.06957362429415724,0.12059596404279696,-0.028735906047534995,0.24566490016111897,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.151125923423317,0.2688498475997827,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11285602187644703,0.09242724798224165,0.22352836435750476,-0.06941212657262116,0.2951241703255152,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11766198804213852,0.21318196661372973,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05573425547633788,0.07334993189965873,0.4482536350943672,-0.08891309222771511,0.2003816031803909,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15555252480121257,0.1600112336084878,0.9334305759126671,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025405572697212643,0.02346264652000177,0.2802099431978115,-0.020863176316469473,0.07167432171089476,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07221689480897489,0.08099000489416049,0.876035315676277,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054913368459433815,0.09055255300140344,0.544926952666115,-0.12365784872181393,0.23348458564068156,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1307892785825998,0.13363518247922343,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014349754997865867,0.08063614363509253,0.9858197655686761,-0.16045086009331347,0.1575809090937403,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.040864703778411685,0.05753998481000393,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09362777283998307,0.11055514844109661,0.3980802773698443,-0.12438891215038018,0.31164445783034633,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1412459097928667,0.1954200767559063,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05906478575571636,0.0775978399910521,0.4474638969207353,-0.0939595109487964,0.21208908246022912,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0484056049792566,0.14915381876733746,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07950673602588612,0.10802002524581726,0.4625792525737161,-0.13351064171492416,0.2925241137666964,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11968995247601344,0.1264476830646225,0.9372011503139762,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015370845773817083,0.06690654733054541,0.8185340374026868,-0.11657003494353921,0.14731172649117338,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.04003096582248112,0.08899901097443289,0.9782788982878687,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009063875226175013,0.08494755332463132,0.9151352806941349,-0.15845418462922478,0.17658193508157483,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1095922624571888,0.0715694368383674,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13387926926029864,0.04237039383723147,0.0018267982419370413,0.05032411207057261,0.21743442645002467,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1147281143710986,0.19051453188479595,0.059922001836761295,0.5726563124259477 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04340931829169611,0.07885743118620443,0.58261174945422,-0.11209891426458271,0.19891755084797494,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1228404203549789,0.1430277616808095,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0546896218088153,0.07540242105179833,0.4691223450810269,-0.09400527037632146,0.20338451399395208,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18763192131119394,0.21284280485671037,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14303128913748317,0.05379358993260387,0.008481168413618881,0.036949389594958845,0.24911318868000748,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18874999502899537,0.31509704696883356,0.18805451080253263,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08257028357967303,0.10283573868738086,0.422975807352011,-0.12022359045780132,0.2853641576171474,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21357431935427232,0.29604045710579185,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03813513566805129,0.04947288767506021,0.44172713874946257,-0.05942626350608055,0.13569653484218314,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10807592409514,0.11185025310312006,0.9325611774982004,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07164700749045247,0.05432447931205688,0.18873540787317922,-0.035481815187149573,0.1787758301680545,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1491610060333396,0.2231056926428813,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09367819625815076,0.07122839620876664,0.18997030335469617,-0.04678544598361463,0.23414183849991616,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2202224887234118,0.27137224053042636,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11035318426044119,0.0685114098050599,0.10883221956313226,-0.02475251330617745,0.24545888182705983,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19041123371483334,0.31516188774273873,0.6983913976492675,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08830081096976995,0.0644603513038697,0.1722861198471595,-0.038816128428774035,0.21541775036831395,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16842570373657106,0.2314984671457939,0.7850787711519817,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08463380080849021,0.09118855613100382,0.3544760418010797,-0.09519162566028656,0.264459227277267,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1819786083492269,0.24130473400324645,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11054232317401069,0.060660289952635324,0.0699153440133264,-0.00908082882305801,0.23016547517107938,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09122139808935158,0.1902857450954189,0.6114670027237653,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14856736179566712,0.09931579357598418,0.1362696499245975,-0.04728511896111698,0.3444198425524512,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2506231861024037,0.3716967997327037,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13158720066448876,0.07288258599829713,0.0725204252177646,-0.012138532753885128,0.2753129340828626,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14281004300989733,0.26687328553048545,0.6230163802798868,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14732522372958468,0.10599773385974151,0.16612284960153817,-0.061704160052611284,0.3563546075117806,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2199576655910441,0.3533277301402735,0.7840604855201315,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14363137718073082,0.07409703147600777,0.05399345535118847,-0.0024892639455647847,0.28975201830702646,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11497207627002613,0.24586787848034963,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1488409336827955,0.08449696444023433,0.07969815711953379,-0.017788557017255763,0.3154704243828468,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.195715763037292,0.3622940551223234,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026633405439159916,0.06804315000238319,0.6959081978454931,-0.1075488756124132,0.16081568649073302,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18665381098952774,0.18293699274482975,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010482140594062762,0.051204483397936935,0.8380079083583905,-0.09049399561012442,0.11145827679824993,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.023382049019245135,0.044368381526058265,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11965882657654416,0.11656103542861476,0.305872391453138,-0.34951922567618837,0.11020157252310005,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.29430065481670087,0.0517626521469027,0.8944539216937829,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0940728732509609,0.064352066614172,0.14536844226538448,-0.03283052684691741,0.22097627334883924,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15126755280662788,0.23149190687719567,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16026752124198868,0.09597863088822729,0.09653413738393832,-0.029004016368163715,0.3495390588521411,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2721844407368019,0.45041938512099533,0.673446463693037,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04484802021957938,0.027254611125025068,0.10144902731207282,-0.008898549270536182,0.09859458970969494,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.04038545412296225,-0.01890054450061386,0.6834764281602781,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028766931562320183,0.05257801660586899,0.5849065790198136,-0.07491783613429426,0.13245169925893463,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09723757233841337,0.09535641034403161,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10155245061353663,0.04128730406921323,0.014764825267786892,0.020133165376405623,0.18297173585066762,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12098693601458044,0.22526246448272488,0.2647257396604304,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08232047635241244,0.0930343156556737,0.3773162274291896,-0.1011448201588917,0.2657857728637166,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10783973882735384,0.15376556093456561,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06024191353527991,0.043086666381005854,0.16363017730088975,-0.024725745629661747,0.14520957270022156,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11553406296017536,0.18287616506861973,0.7815260814768127,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011900276820167525,0.07188843189649782,0.8686893348310524,-0.12986496733379788,0.15366552097413294,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16844045669367694,0.13454327495741647,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014580573522043951,0.058529090349715866,0.8035287430561249,-0.10083981560931493,0.13000096265340283,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1625807472246423,0.13889924872972548,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1408497030361027,0.08609021265392713,0.10341329168975885,-0.028921700987878413,0.31062110706008383,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19867214707552408,0.352101815527977,0.6840511279380797,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11370030602166033,0.0678832454078136,0.09552480050423291,-0.0201666403746356,0.24756725241795624,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1420280816500102,0.2347469565773732,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07815217656977004,0.050659931794557723,0.12450460172682447,-0.021750094354970856,0.17805444749451094,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08457697413883308,0.1450320167411909,0.7259506085296737,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15271571986792495,0.09303133485906995,0.1022703992088586,-0.03074369846037872,0.33617513819622863,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1891475228491191,0.36123753352229954,0.6839279097893172,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14227023282194426,0.048167091206880626,0.0035202945244121,0.047283887105556324,0.2372565785383322,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17037162309303205,0.2926059571851927,0.09909254586802571,0.9469972658835614 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07584310835170698,0.0642451735811896,0.2392072406394211,-0.050849496816871356,0.20253571352028532,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13766754508337017,0.21502886468582844,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00527374129734606,0.07827534464339286,0.946351766768186,-0.14908660642289645,0.15963408901758858,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2178318894244507,0.22767398926412347,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1447798229741384,0.11712283113705284,0.2178722005215476,-0.08618844708151777,0.3757480930297946,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10251511232113582,0.2784741010546513,0.8322459088982637,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047721107736983535,0.09514137148564213,0.6165195034658966,-0.13989933969779014,0.23534155517175723,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14767953983641616,0.17010107198055355,0.9562195815772346,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16441390302054598,0.09071272271491665,0.07142865313654141,-0.01447317163516948,0.34330097767626144,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09613171744012203,0.2521250792536144,0.6190382519293574,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17090781508186897,0.07228433990592098,0.019027687778445063,0.028361833413706683,0.31345379675003127,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18278051311459753,0.3425496704505326,0.31532731854968044,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04593879848063806,0.04867559174437461,0.3464349038309863,-0.05005031918317594,0.14192791614445205,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.03626731682343351,0.09653244554568595,0.9075908470661285,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04600356911073501,0.21045187752722572,0.8271912824276771,-0.36901121161591255,0.46101834983738255,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2775677155859899,0.24413515896976845,0.980914908860308,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12293324733835166,0.09656218462820118,0.20447552737173533,-0.06748906844628459,0.3133555631229879,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.185827890258868,0.2903420651066186,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09706559493272876,0.08678770355960788,0.26474032375987433,-0.07408127334788497,0.26821246321334247,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18125533492030063,0.24455208770550924,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05418433265044527,0.05413722744570775,0.31811120068263565,-0.05257522607395927,0.16094389137484982,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1073478655458879,0.13917890147002318,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10138551921272418,0.07369732274631138,0.17046828196036273,-0.04394688931256738,0.24671792773801574,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18648589831805001,0.2606181908559174,0.7844207095472905,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08664948162217626,0.049572855001763796,0.08202762167314448,-0.011109054867427401,0.18440801811177993,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12991805652729177,0.18694143905720048,0.6430699474171485,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07901421377976628,0.05798848133850162,0.1745612647871627,-0.03534008493280359,0.19336851249233616,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11890823454710359,0.16629333116589243,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09087195913409149,0.08166237169733075,0.26715364799836777,-0.07016766513441278,0.2519115834025958,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12901968173447176,0.234124135429223,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02190530340185398,0.07549800454522958,0.772009609349313,-0.12697808110292164,0.1707886879066296,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15826585312667132,0.12894637997287245,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0926234476498711,0.06577947292576355,0.16067245461850901,-0.03709482264243616,0.22234171794217836,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1971039895335553,0.2670503986324954,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025041733291789957,0.08453908159110676,0.7673764473890954,-0.1416708131658983,0.19175427974947823,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08411205761292165,0.09294306564014787,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22578317395767578,0.08760198727416023,0.010682246613055443,0.053030523960049314,0.39853582395530224,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22177958520066915,0.44552138044762774,0.21146053270432444,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06632836358029186,0.04631781099270527,0.15371277309656237,-0.025011169232329877,0.1576678963929136,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16315706453027412,0.22626991732987017,0.7711789647234355,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03712312737748681,0.06416315733233822,0.5635342588078802,-0.08940774031489022,0.16365399506986383,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1829480200444457,0.18723611097270312,0.9517733928546709,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1801621999504276,0.06511462345291699,0.006196434046761572,0.05175502443870242,0.3085693754621528,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20125107933193664,0.38833420630523563,0.15181263414565851,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0941080422790901,0.052690425754200715,0.07562050631636939,-0.009798398222702925,0.19801448278088313,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18315231331311096,0.25111536311095517,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12642757127645451,0.09562406512849572,0.18764974733984982,-0.06214475645846579,0.3149998990113748,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09374859256475147,0.25459619184219046,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06105442952804665,0.10709205866574205,0.5692483119286713,-0.15013298189800955,0.27224184095410286,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23094114792198372,0.26654555718298617,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01635558806136106,0.06126025531096941,0.7897583405405094,-0.13716188223115944,0.10445070610843733,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14978519119345163,0.08884725122123657,0.9728992869406584,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03799582590771408,0.061638404242169605,0.538318144432267,-0.08355618456363531,0.15954783637906347,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11052775741804743,0.10038429214439511,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09775663071789938,0.10422177862445843,0.34940389251873016,-0.3032837997362665,0.10777053830046775,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1913263486093408,0.01726755370913023,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059161283155195137,0.0591863095630068,0.31873519576912857,-0.05755515375154171,0.17587772006193197,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08856845102215458,0.10577345543998311,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04560485500698218,0.12280615053152147,0.7107691264781631,-0.2877807302406428,0.1965710202266785,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20187070618782205,0.08004921660559232,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046362383816448596,0.07659840613507242,0.5456955989203686,-0.10469101185613329,0.1974157794890305,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1163697051835586,0.12086732921922454,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04500845203669297,0.08682112114643843,0.6047549725256391,-0.21622122038260355,0.12620431630921763,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18231757886086317,0.06985961193985465,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08057012562108044,0.081688441751217,0.32518474505318473,-0.0805209092493356,0.2416611604914965,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13111061863472442,0.17335375511459944,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015243559251982569,0.05367928643465078,0.7767265065545074,-0.12110005029876583,0.0906129317948007,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12678244715851772,0.0816576060321644,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022714460305507382,0.09057361953577368,0.8022407736391353,-0.15589830044971587,0.20132722106073064,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15764593006465694,0.1432372859247635,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023803469171418346,0.02996088182017259,0.4278644053777746,-0.03527991342927782,0.08288685177211451,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09944124858025977,0.09102818331689581,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022758076691186704,0.05801141490453572,0.6952559967945304,-0.09164144741443148,0.1371576007968049,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09322793268770102,0.08437382735806559,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016767750761280557,0.15982158478538835,0.9165491166936042,-0.3319387092931782,0.2984032077706171,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.24084367963768705,0.0940834701653895,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10258113234392752,0.06967746998004996,0.1425470032865073,-0.03482405626797758,0.2399863209558326,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05786841627520117,0.11605363957197827,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07293532552145691,0.07221612921457334,0.3137475747685215,-0.21534679451410654,0.0694761434711927,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1002074033005484,0.005484673131630996,0.901410374901842,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11299488943587467,0.06418526494599744,0.07987563093796562,-0.013579574857031554,0.2395693537287809,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12170360333466279,0.19352266183645844,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058836457567472494,0.03761807179848492,0.11940321751551017,-0.13301995263649513,0.015347037501550129,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11448896379971295,0.02052278235706227,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06097561440124922,0.08095220824113696,0.4522065269637231,-0.09866355511952196,0.22061478392202039,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10306978475090596,0.13129837255323307,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03812572906863025,0.05054552077323388,0.45157422795268143,-0.061550921322403196,0.1378023794596637,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11226443333811562,0.1300785042454389,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14298309881946988,0.04420217266676798,0.0014267411348023392,0.055815641762371734,0.23015055587656802,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16001069791676092,0.24617818868652047,0.048607172223437634,0.4645239336088109 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06433608525183875,0.05111632112015182,0.2096491880991047,-0.03646619339967053,0.16513836390334802,197,5,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08714603824930389,0.13292031922955735,0.8238590371934124,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05113790215355433,0.11195270344516044,0.6481068226333855,-0.2713096858479296,0.16903388154082094,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.050550205538605474,0.06584668354993152,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16918070156813686,0.12225852353894091,0.16728829863297567,-0.07125902316432567,0.40962042630059936,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.006560955030370635,0.21292611054176266,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10601244925975432,0.07868551639237505,0.17874275985236143,-0.04873442117654979,0.2607593196960584,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.058693503861224856,0.05374414166511869,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13470775016407777,0.12249713041533669,0.272214271876833,-0.10620123078070604,0.37561673110886157,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.1560539984907259,0.3943614722129031,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0779578124857021,0.08154039960736413,0.33968884596833515,-0.08240361401169058,0.2383192389830948,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08034886130944932,0.13455140135123794,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05899185221076925,0.09686532479617792,0.5429069157545172,-0.13150833833582562,0.2494920427573641,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.07747947255335684,-0.02581939313644808,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12228726822136575,0.10550948554165088,0.247226159683057,-0.08521296101392371,0.3297874974566552,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08353913492032618,0.2298960263616534,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022622547663817685,0.06045193243770154,0.7084606632575596,-0.09626524497533342,0.1415103403029688,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03405879837152247,-0.05370043874539767,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06949504932290013,0.07190308440852984,0.3344451664587974,-0.07191315128485029,0.21090324993065054,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.048083511424817774,0.1103868417216854,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1294916638181751,0.11299068512806495,0.25254901894365817,-0.0927214665479143,0.3517047941842645,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.14381089946825668,0.3375811666365858,0.861510147131396,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06509577198606961,0.06574866587122301,0.3228124180880385,-0.06420884143475478,0.194400385406894,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03756719933710053,0.15935737991595295,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12937399875555225,0.1217235037923129,0.2885697703413602,-0.11001352939476608,0.3687615269058706,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.15706397856711987,0.34465302251519014,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0889089267542608,0.0750193884369312,0.23675025281180165,-0.058627953156023746,0.23644580666454534,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.051394157908544603,0.1806596141478795,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05266255794176787,0.06883200845498269,0.4447259098554204,-0.0827059111566439,0.18803102704017965,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03345478297564875,0.07829764145787771,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1949568089185425,0.2650961515306151,0.4625684283153483,-0.32639453621981407,0.7163081540568991,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09258706086162953,0.0988738380800436,0.9372011503139762,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21397625790283803,0.1825377194883878,0.24188842663526475,-0.14501154725497667,0.5729640630606527,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.28542485631975056,-0.14255853768395074,0.8491564414671808,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06112792609456357,0.0570905792982921,0.2850214975651433,-0.05114926140906272,0.17340511359818986,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04544711042068064,0.09496660839543877,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11377433446926559,0.07845548291394393,0.14788961444393203,-0.040520140627783405,0.26806880956631457,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0418779717194297,0.19823638412129982,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07011435765477637,0.07110145403751303,0.32474539335745134,-0.06971731658765219,0.20994603189720495,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06046979141143354,0.146568464516794,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07914117648363239,0.07200599704091311,0.27247089791543244,-0.06246941725210181,0.2207517702193666,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.011143734134902135,0.13796481278388445,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12186486214309566,0.11464263341182751,0.2885034943229545,-0.10359707230734555,0.3473267965935369,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.015717277809042564,0.17458789524394455,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13868736293959177,0.10893374774309263,0.20380088020359874,-0.07554719153776712,0.35292191741695067,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.024543737777131945,0.2224636899807646,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05263681588837116,0.06495017338790533,0.4182411538511208,-0.07509744229395984,0.18037107407070216,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09586022575456278,-0.04661872493501475,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09853338886086202,0.1315759185675217,0.45442946307734944,-0.16023039075994558,0.3572971684816696,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11764960455849559,0.2788425701706513,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05142113249095575,0.07928117286464609,0.5170202902859573,-0.10449718574368808,0.2073394507255996,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0201761372387788,0.09374673175831616,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04061413803970164,0.053680825496095444,0.4497985815468547,-0.0649572571651611,0.14618553324456438,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.027875267811143186,0.0788532089819403,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08897857633727099,0.0721468419663072,0.21827819244805874,-0.05290901007031512,0.2308661627448571,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.06340337112547788,0.03964603430501844,0.8330251402176395,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01370984251165103,0.04537882115377855,0.7627371278834619,-0.07553441589314568,0.10295410091644773,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.016409927584557702,0.046265684868053165,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07177229141668955,0.0769382256232636,0.3515265212973968,-0.0795382696369079,0.22308285247028697,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.006463420062626003,0.08167613162045588,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04059371376322054,0.059221968577765585,0.49350592900553836,-0.0758751704566768,0.1570625979831179,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0866731855796763,0.1476189314210396,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02604852582546321,0.057294029492892355,0.6496407285599104,-0.0866287770023995,0.13872582865332592,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06940521494916996,0.11475356601704542,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11352946156708757,0.11656538434196788,0.33074009811005445,-0.11571385099090772,0.3427727741250829,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.049809815886572475,0.17817038732618765,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13093115660183305,0.11302944530618707,0.2474850958422148,-0.09135820146837462,0.35322051467204074,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08650572036868201,0.25256668405693855,0.855600896698613,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07758101839994712,0.07516262760530562,0.30269063008142716,-0.07023756282013512,0.22539959962002937,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02667427414648754,0.12296068192910399,0.8905701340201515,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10834375122154379,0.11183714166187694,0.3333208469249498,-0.11160076289229033,0.3282882653353779,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07563038403367481,0.22099827852612183,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04691164811438794,0.060575974848438796,0.4391925569964841,-0.16604338876002153,0.07222009253124564,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05108064536068218,-0.02181377956145534,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13033385035061104,0.1093174503780247,0.23395691226478701,-0.08465531291189982,0.3453230136131219,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.029622485262915246,0.15842026204388784,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012495650661689905,0.03597074253771616,0.7285083358950913,-0.08323751130125508,0.05824620997787526,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04548229407294755,-0.010920066827241568,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010188694439162378,0.05263039238288029,0.8466076810811527,-0.09331686648862544,0.11369425536695019,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0268048329145847,-0.02787505023748792,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01925897532795354,0.04621278720879971,0.6771156684442592,-0.07162540241495735,0.11014335307086442,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04727251171568624,0.05020057736650657,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036274105738011084,0.06348671739594271,0.5681125961142248,-0.08858204672473392,0.1611302582007561,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.02385748900687745,0.0035348154663721043,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06885743826433628,0.05727341522667221,0.2300625394605436,-0.0437793235169633,0.18149420004563588,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0721121051905656,0.14989920351304148,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02736748169880073,0.05774241210118513,0.6358203588645641,-0.08619163278351405,0.1409265961811155,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04452894518449627,0.05369581608483036,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0787579575770536,0.054815010196618025,0.15165436475353583,-0.02904398196366119,0.18655989711776838,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.060477836007393766,0.12090164526729172,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034920865767951795,0.04705571318053086,0.45850551614318535,-0.05762125233322808,0.12746298386913169,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.019477550938220563,0.05255213753317385,0.9366135780422296,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06310434319372966,0.054345327605081144,0.24634942013560177,-0.04377389508058804,0.16998258146804737,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.034089199163143694,0.08886087971090288,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047900254646054706,0.07666053226103973,0.5324790158582926,-0.10286418075805479,0.1986646900501642,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06587065800819479,0.11269592521164595,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020212557293690255,0.03997176313840424,0.6134006487211556,-0.05839791049106051,0.09882302507844103,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03434530809482112,0.05353565485009428,0.9553020108982802,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027115809206197185,0.03876561491671093,0.48470829056182363,-0.10335420559653007,0.04912258718413569,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.037523386227265296,-0.02680191070958437,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07328251515665198,0.06759453624297043,0.2790326360877336,-0.05965227922193113,0.2062173095352351,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03361596409610357,0.10798130838898798,0.8744417944194353,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016113166635236764,0.03869932242547803,0.6773915154757382,-0.05999485562753035,0.09222118889800388,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09135189285107934,-0.07973554045414348,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10554317771936697,0.06487982536965364,0.10467522838523968,-0.022052730533206194,0.23313908597194014,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0031638946246393307,0.05223920600674602,0.6872720950554446,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11973855247376675,0.13512630911847676,0.3761493375403405,-0.1460076027070767,0.3854847076546102,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-9.632865955062025e-06,0.1606050864400817,0.9167557388379561,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05397185430595798,0.08720802942000207,0.5363870754528994,-0.1175358163353215,0.22547952494723744,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.021668812795849122,0.11984309237932829,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0455514728868422,0.07982829939706117,0.5686185273816438,-0.11144285174015603,0.20254579751384041,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07581056561243744,0.12951609974931394,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05789579587977568,0.09745775909292652,0.55284901370377,-0.1337695055736831,0.2495610973332345,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.15405114205696913,0.2258014686587063,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10351883000474947,0.08217332043838833,0.20858044912411008,-0.05808733024194644,0.26512499025144537,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0010666953164133767,0.0979263664243368,0.82185729615414,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032790020039323,0.12992086486756793,0.8008894877426104,-0.2227188482303952,0.2882988883090412,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.17136197032385345,0.30528383109470625,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07789410830666695,0.08073477212258093,0.3352924767151072,-0.08088293090163436,0.23667114751496826,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07143022805841892,0.16201476629187062,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011078854938772562,0.07442803962649405,0.9881320066909243,-0.14526601828119257,0.14748178926894706,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09011624870443498,0.1264519317721625,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06451200011592619,0.05565127961779276,0.24714401796214527,-0.04493458867793769,0.17395858890979005,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.01722571442188698,0.0019351290209614846,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12590315958054196,0.08199407827603758,0.12554554771962978,-0.03535049406842508,0.28715681322950903,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.025076713025220743,0.17658219558184168,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09608525213527838,0.07219200448969246,0.1840512919985259,-0.04589115314870709,0.23806165741926386,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03505151685143991,0.09837490247429699,0.8036298987262369,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07954862848021291,0.10679865376898787,0.4568558016155714,-0.13048694344319609,0.28958420040362187,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07907446290007415,0.22097374651156776,0.9353936944091839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14093644188149054,0.1047453323263264,0.1793152506246918,-0.06506096543653997,0.3469338491995211,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.016074173130068026,0.09935270099973027,0.7982357106299288,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02671504424026498,0.06835264893873262,0.6961482687848395,-0.10771069246780886,0.1611407809483388,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.012960188339088026,0.007964347853457777,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1213500466055671,0.09698336274963366,0.2116663485286566,-0.06938228328162631,0.3120823764927605,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03316230399465957,0.14060787701810326,0.8272808836142177,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018113420395044374,0.06544685599475468,0.7821209280708818,-0.1105976386336687,0.14682447942375745,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.025297040130296343,-0.035074903727144495,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0234577674054617,0.07203443230839825,0.7448830745316486,-0.11820874854893602,0.16512428335985943,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.022599475015444237,-0.03277193710551739,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027129265208449906,0.07404892018361448,0.7143070186364424,-0.11849904331609606,0.17275757373299588,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03434501210282368,-0.04203472801485124,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04633513116851599,0.054857580428466286,0.3988768435987923,-0.06155052911845935,0.15422079145549134,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11191327885688208,0.16503130602601684,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005468785747997614,0.06917324534621068,0.9370299059585456,-0.13057077688091379,0.141508348376909,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08643802905167082,0.08254876273289496,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03046368799529551,0.059086771125558,0.606470989856639,-0.08573931015586514,0.14666668614645614,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.023944885753635715,0.040019782995388435,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13095223625573726,0.10535856314178033,0.2147154069914778,-0.07625118144256943,0.33815565395404396,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08278186131081307,0.3234388637494369,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030249562671269412,0.05089514728327381,0.5526551411713527,-0.06984337848968598,0.13034250383222482,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.017859795677077673,-0.03256245356995917,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06478142574595099,0.08951347925006467,0.4697216272217545,-0.11126025779258221,0.2408231092844842,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.13631032095775505,0.24475334374235155,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042189659529164286,0.06129970038920017,0.49174214038574626,-0.07836539594774233,0.1627447150060709,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0618095595079614,0.09433369193206691,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0039947964123953515,0.053281356392554824,0.9402763164100139,-0.10079098288190196,0.10878057570669265,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11431598747045402,0.1406437888487076,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06051303884064261,0.056948671271646795,0.2886885882110791,-0.05148506524306117,0.17251114292434638,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04453434942118405,0.10134403092684688,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04630340080538388,0.0636370812820801,0.4673265315003744,-0.07884846479331324,0.17145526640408099,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04567310660030448,0.09308986085139563,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062342813935237815,0.06970289243406147,0.3717079959570736,-0.0747383791364593,0.1994240070069349,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07410102352014021,0.1797544108647103,0.915561182973695,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023170806061228236,0.058621068379290146,0.6928846984681005,-0.1384579299086711,0.09211631778621461,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04860421949400264,-0.014785154262099115,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012583599426635544,0.06502533117738309,0.8466633453778605,-0.11529846782201202,0.1404656666752831,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04462962418101533,0.05845234787021947,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008199160382250176,0.04971455402289728,0.869096818698705,-0.08957196704883862,0.10597028781333896,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05404408718632822,0.02803738455255709,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07389175915461724,0.05745287838433087,0.19923421364462351,-0.03909794384483245,0.18688146215406692,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02394842614245364,0.1234226818050855,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025429435338490906,0.05541049367728734,0.6465658315886273,-0.08354361178663093,0.13440248246361275,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0426187035959815,0.0757380042588698,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09378933114906315,0.14675133011711108,0.5231664060215311,-0.19481917152308184,0.3823978338212082,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.12734773802759783,0.25204289763814525,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008137267196383507,0.08155347631371626,0.9205764997325938,-0.152249876605494,0.168524410998261,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0679247884347943,0.15897930060017637,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08849770966853401,0.08449098938050904,0.2956156506498177,-0.07766649419208618,0.25466191352915424,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07800414708547647,0.191066290238384,0.8831753988928314,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04465801980339201,0.05369251022901134,0.40611524183154535,-0.060936355181403834,0.15025239478818786,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03054157835994755,-0.0024882723390311605,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0417448133100391,0.08748899766420934,0.633552662758732,-0.13031542352736528,0.21380505014744347,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09245524120485085,0.19206472368235897,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027073724905524715,0.07320101588360406,0.7117108284498921,-0.11688705263146569,0.1710345024425151,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05844735930273761,0.07999934088816324,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10854959981805024,0.0737927753033996,0.14217288439964207,-0.036574961379047616,0.25367416101514806,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03397967551094342,0.19417672668886982,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008642057141583535,0.06128429362826688,0.8879371743815071,-0.1118826986290074,0.12916681291217447,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04198692811769382,0.04419769486587198,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09410668610847017,0.08853860471185517,0.2885528662992401,-0.08001776042416117,0.26823113264110154,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09670048403754271,0.25868099359520746,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007173552896425112,0.0485281595520034,0.8825665547333594,-0.10261145764701113,0.0882643518541609,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.06330904474028691,-0.08323041200154499,0.9870366109823806,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06761032946433919,0.0757908075082578,0.37296063041995,-0.08144366175887612,0.21666432068755448,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.09127848749121599,-0.016968236881950607,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05410304443654482,0.0866761318430425,0.5328975278884818,-0.11635856983755394,0.22456465871064357,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09400013161237682,0.17858566206043064,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0584373711861048,0.08508593140463241,0.4926532728359535,-0.10889687540340894,0.22577161777561855,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.058355298739412566,0.16187981630228465,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021194374437144402,0.044879884249920426,0.6370401014986231,-0.06706864970806871,0.10945739858235752,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.030426752815497924,-0.027869085286112222,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055569907717496245,0.05112155603265487,0.27776552534982446,-0.044968300209345335,0.15610811564433782,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05711281386629223,0.07437994127261469,0.873574778219852,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018833811610988346,0.061745325064624476,0.7605260558274015,-0.14026525485368443,0.10259763163170775,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.017463384421257333,-0.004526366390479411,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050900669133235224,0.05377937605946499,0.34454991194828677,-0.05486454053660636,0.1566658788030768,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.01392787419286764,-0.021293109886007553,0.906241617311299,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051534189683378695,0.11087604042392592,0.6423652517748217,-0.16652017468544095,0.26958855405219834,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.12457495227008879,-0.07340274205628641,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03727632517267339,0.05821675221429319,0.5223879256807697,-0.07721565029081412,0.1517683006361609,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.012471579103875318,0.01853096959332088,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1126920333391629,0.10170056548363254,0.2685767303831013,-0.08731738328226259,0.3127014499605884,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.13287956061624007,0.0043941049938629375,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051183286640096456,0.04684086058436901,0.2752618125932709,-0.04093629160387047,0.14330286488406338,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.00019677761989330992,-0.026982998210579402,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05331236248978705,0.09712417509658919,0.5834117981616116,-0.13769689599887222,0.2443216209784463,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.11800932943850141,-0.04167598287066515,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0351836600425976,0.046286510774404356,0.44768134225171674,-0.05584570615025666,0.12621302623545186,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03937821221653856,0.032084364112946726,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018628526781743523,0.042157801014308785,0.6588471251810446,-0.06428111238118778,0.10153816594467482,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.006195341760565475,-0.024901049201293463,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023740832955115806,0.05546239006810674,0.6688714983186359,-0.08533427620676251,0.13281594211699413,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04540500613777188,0.052419175517108695,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054489360365878974,0.06274972398187437,0.38578219972847483,-0.06891738400261738,0.17789610473437534,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04615497646621238,0.0866650307247003,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13700783681045045,0.10391150672253684,0.18818228271013585,-0.06734972738787981,0.3413654010087807,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03317438253822294,0.18415356837527502,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012731014780617656,0.09374950566837036,0.8920575624326637,-0.17164145009319354,0.19710347965442887,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08869530116170855,0.14307990844850202,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014235347473957969,0.0527043070946405,0.7872410810429498,-0.11788627276927509,0.08941557782135916,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.03586552163909907,-0.09146836846443399,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04029888635131286,0.07090340511377453,0.5701466986697548,-0.09914329497619369,0.17974106767881942,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06096585657575051,0.13288206866327484,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03493384297051908,0.0636775273575498,0.5836200752866121,-0.09029756590230689,0.16016525184334504,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.033482610777307194,0.03626861157273166,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019996920070156098,0.0732885752616963,0.7851253378171741,-0.12413605611734016,0.16412989625765237,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06402613189244075,0.1271708402122698,0.9722536916492144,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05093640071421508,0.06770488561585225,0.45234991351490483,-0.08221541225801769,0.18408821368644784,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03928613703106963,0.08254006589144516,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035429163775952156,0.0752505932196956,0.6380606697937918,-0.11256241501924893,0.18342074257115323,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05879408198617218,0.10214940955606491,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09893347870231022,0.0876646856076076,0.2598500702606555,-0.0734722748281371,0.2713392322327575,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0472441504767314,0.04858363249418512,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06899782931733281,0.11339905264873042,0.5432760408681854,-0.154018417031318,0.2920140756659836,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.1283902989948482,0.2407670665140441,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07468620211344831,0.0867249635238639,0.38971603752599115,-0.09587144698550404,0.24524385121240067,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03241303967060252,0.14637735904045374,0.9196137660184385,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09820378704024303,0.1198323794000678,0.4130440187201606,-0.13746456133312152,0.33387213541360755,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09737894964106732,0.24701583252188844,0.9263451842579509,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12948546304382144,0.09174953431265251,0.1590316110309353,-0.05095375817284348,0.30992468426048636,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.010105474729309557,0.12992926846668312,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02249636413256217,0.08755378805915871,0.7973709354925395,-0.14969129273475917,0.19468402099988352,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09332747853736746,0.1855938639305858,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03415655624114628,0.06830211456773269,0.6173273582155616,-0.10016979704644252,0.16848290952873507,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0196602254997561,0.026491072833083586,0.9570174945596325,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.092435708351975,0.08218205897255458,0.26144535228566973,-0.06918763753289713,0.2540590542368471,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.13589509324233953,-0.04077233695891532,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025810791690085752,0.07883668857594739,0.7435610636506677,-0.18085496490048858,0.12923338152031705,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.10904986625750444,-0.03548578921224342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0487171432247214,0.0596531124609975,0.4146609322701583,-0.0685996501110696,0.1660339365605124,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0075511853824476805,0.06147101665362238,0.9266831307321275,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09044409032964777,0.09666437093629202,0.3500872844949018,-0.09966089430936469,0.2805490749686602,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.1244755721547472,0.2890714509090745,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015217487871672248,0.05388757891387285,0.7778061066338662,-0.09076051894127246,0.12119549468461696,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0641183071672962,-0.06914455809787261,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030035009086584758,0.043925772274425554,0.4945668952406176,-0.05635161074658983,0.11642162891975934,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.019824604304632187,0.014762109042817145,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005636963405394293,0.06411086065418456,0.9299855256883794,-0.13172058720397212,0.12044666039318352,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05536742049939218,0.08648945780488217,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0169920318920318,0.05303758843608224,0.7488704012275147,-0.08731434115183591,0.12129840493589951,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02524663046584581,0.021748206882381778,0.9640825891897521,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010343927540207723,0.06230223998330518,0.8682290227865178,-0.13287062750506062,0.11218277242464518,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.037081936534998534,0.04925588873444325,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006535776830013011,0.04093500344407319,0.8732376463880248,-0.07396904749726944,0.08704060115729546,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.022292351351684413,-0.014466274846595397,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022366901174004954,0.0626163486156222,0.7211496572665018,-0.10077754053109018,0.1455113428791001,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06535434018047122,0.06973311952601073,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1407554866472119,0.10021237056064371,0.1610204788856333,-0.05632717143604335,0.33783814473046714,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.08959661674338552,0.28402818522124623,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09318778135036355,0.09553266015670854,0.3299971208617235,-0.09469152428939988,0.281067086990127,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04448965862104119,0.15491322513526318,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050286543179385475,0.03765938613115393,0.18263164881187213,-0.023776288375128553,0.12434937473389951,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0133369195748903,0.04186672904799102,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13414478822726422,0.10769014918791021,0.2137102192905846,-0.07764404315749976,0.3459336196120282,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.05929324423821548,0.25511171783218456,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05638579645082731,0.05942538518385569,0.3433404015434002,-0.060483137036463144,0.17325472993811775,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.028697226970109357,0.09053565361607366,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08523937874901612,0.07608182434752696,0.2633136889411353,-0.06438694073975444,0.2348656982377867,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.04518347645579653,0.04227585673549496,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06116382100844584,0.09447416739902925,0.5177818253832702,-0.12463379985449588,0.24696144187138755,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11257590550061929,0.19700085001872342,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09791837192346077,0.09742322998585201,0.3155398405358363,-0.09367902286173528,0.2895157667086568,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.06631193602329225,0.08160679877753345,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09776200435916331,0.0980850952814533,0.31958420520265685,-0.09513704780645792,0.2906610565247845,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.013325260889999392,0.11776665386314404,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0914869329346783,0.09230455738515875,0.32228937328895535,-0.09004382440487346,0.27301769027423006,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.024867740173121197,0.16687524877963308,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02291359132710601,0.08301231303438672,0.7826879397545823,-0.14034257370449288,0.18616975635870492,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.09603512057487874,0.18135345784842824,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08609422321260311,0.07630418289769704,0.2599518627535607,-0.06396939771779474,0.23615784414300095,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.050855110654302704,0.05920229753999989,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11473905802813723,0.18378744577952585,0.5328284659307264,-0.4761846373904347,0.24670652133416027,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.16352558130836725,-0.024002458985077624,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02450478564138044,0.06427149630850576,0.7032304427067949,-0.15090432354875993,0.10189475226599905,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.10180671905093641,0.10738511137629281,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010775603324491219,0.06006592812279635,0.8577286216579503,-0.12890426057958226,0.10735305393059984,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.10451050293302949,0.10324289997484068,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07348073288897121,0.06753466078691528,0.277311408122682,-0.05933630742424774,0.20629777320219017,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0695044761576531,-0.027165812910448166,0.8731844338269933,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0032396245226133887,0.05464852150743605,0.9527614762435944,-0.11071413908354563,0.10423489003831884,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0628212609397157,0.060117194956986864,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08268265946471053,0.07023748323495899,0.23990726465004603,-0.055449886603011964,0.220815205532433,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.02767538439494188,0.03446532875820252,0.8466912699522725,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08168614436233024,0.0734165640360679,0.26661418064531145,-0.0626985409476711,0.22607082967233158,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.0522989984772505,0.0010085794725044103,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06412148294922974,0.07264759253336675,0.3780278077768886,-0.07875090455866636,0.20699387045712586,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06971517544483788,0.16582726911967854,0.9171668992289758,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010315492073273395,0.04399515060749909,0.8147558094129546,-0.09683855480485486,0.07620757065830806,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0745515088150061,0.014843521871435797,0.9770888048613304,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06271936922339541,0.06182815871891985,0.3110740263760269,-0.05887497882512406,0.18431371727191487,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07231569183458465,0.1268587203093154,0.8977920836150588,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09631717281039884,0.07212191785991945,0.18257345312273263,-0.04552139660347915,0.23815574222427682,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.04987828370326496,0.04510003298366261,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1391713788182462,0.12351505413508261,0.2606044038605756,-0.10373950180510191,0.38208225944159435,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.07445822220275536,0.2652329468605589,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10488971250241207,0.07910689375445619,0.18571505664563157,-0.05068585972101129,0.2604652847258354,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.024094171696946175,0.08428945769246085,0.8073060060237306,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06385261140616205,0.08936902713871377,0.47539705853439396,-0.11190498538827454,0.23961020820059864,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.0410167209602422,0.10213077839061473,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17384815002249587,0.0875438886851487,0.04781777963765027,0.0016799617590239346,0.3460163382859678,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.031321629387063815,0.23611022331917772,0.518548544759109,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02699949636262879,0.05070736268034497,0.5947415983589681,-0.07272413820987575,0.12672313093513332,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06203228308051085,0.08459095047183914,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07553800001962148,0.1484769300802236,0.6112409057280241,-0.2164641538117163,0.36754015385095923,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.157376951815049,-0.04514545585337722,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07583246399219935,0.10824521401821693,0.4840341146657694,-0.13704798563842957,0.2887129136228283,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.11378331189051924,0.21952189459562224,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031117912425513473,0.05130002870393181,0.5445118831019653,-0.06977128877944035,0.1320071136304673,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04152275312693831,0.03691413257976592,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0333303909375325,0.05820588679284228,0.5672572411822434,-0.08114021604491062,0.1478009979199756,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.049064369892676825,0.04667908294086083,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04534217606475854,0.050973408302989846,0.3743210993983025,-0.05490467713024668,0.14558902925976375,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.031232344260220132,-0.012836350763482269,0.9159127256227925,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005013155295251126,0.05284868504154261,0.9244804642544624,-0.10894802147915196,0.09892171088864972,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03084846354136358,0.003476894880723816,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022954576694875238,0.0723241920913175,0.751137938147195,-0.11928179533521319,0.16519094872496368,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.009933424208461567,-0.06144180435775889,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044856796431189755,0.05220169209170613,0.39075450830550673,-0.05780566107101309,0.1475192539333926,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.042535783916034124,0.05736317115555991,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023698214558673273,0.057605501629319794,0.6810355685173042,-0.0895916449448031,0.13698807406214963,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04291677866268568,-0.0036942521513758124,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028560125104768363,0.06273549137262746,0.6492092865891486,-0.0948186287028207,0.15193887891235744,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03989384021012403,0.04840694706406599,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023710007826163705,0.04905917726165021,0.6291840718439268,-0.0727722229005566,0.120192238552884,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.032775890269523406,0.02476230862999215,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010378343933492058,0.05951776194509743,0.8616707492322668,-0.12742895017783626,0.10667226231085215,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.06617996095084552,0.03126942863100614,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017684193970986316,0.04201891029836876,0.674109263502662,-0.06495229576610657,0.10032068370807921,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.02057036251561928,-0.0011097557321781124,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059520974770167885,0.051271679105265644,0.24646292577915638,-0.041312472696704856,0.16035442223704063,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04836248843465225,0.08159409637570099,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004762388079114381,0.07689485963466168,0.9506503357468736,-0.14646288725320672,0.1559876634114355,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.051263357310323034,-0.08177287568082826,0.9938446417962179,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010120777707949388,0.05024203757865689,0.8404692525635473,-0.08868772525554834,0.10892928067144712,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.005471778763360378,-0.009696512873396896,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02291655101689624,0.05715559793735462,0.6886972919149253,-0.1353216074267235,0.08948850539293103,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.047888205657375844,0.005023811038713091,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04038518822285333,0.07037753345558226,0.5664408872937058,-0.09802278761058733,0.178793164056294,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.04271045462546118,0.05849922109667781,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009233706345172368,0.05773942615465439,0.8730345540676834,-0.10431953582541202,0.12278694851575676,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.03245729356093741,0.006583895564791285,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05058692886559481,0.052646641814858924,0.3372663544490312,-0.052950589007515994,0.15412444673870562,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.023152634641798887,0.05594290126898236,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02541454858377947,0.052458905482835536,0.6283532134684222,-0.07775375763285644,0.1285828548004154,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.053917833006453246,0.07968435561458498,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029129475659001963,0.06547763518539212,0.6566792039415403,-0.09964211526483087,0.1579010665828348,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,0.056636371203747954,0.08090299710649836,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036197661374920156,0.06311681808407354,0.5666665226073209,-0.0879310286079085,0.1603263513577488,352,10,362,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Uterus,False,356,-0.054713293523917246,-0.06508730294379593,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052667973939813185,0.06258938396499623,0.4005758067383568,-0.1757104367422176,0.07037448886259123,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.050243550480914535,0.07514719140633198,0.9219399112464703,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039373143727224946,0.08593550997963872,0.6470766698630463,-0.1295647195370758,0.2083110069915257,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.001557109442987959,0.11580614036897836,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014350257495960977,0.04667533773205263,0.758660918382076,-0.07740729215331515,0.1061078071452371,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.04486795797319836,0.020108598054144465,0.9669637716950737,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003851456276579898,0.07916309593529798,0.9612205968530116,-0.15947564795083422,0.1517727353976744,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.14033408662009647,0.22013434063908607,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014077803305938654,0.055388072851956606,0.7994964125675541,-0.09480783291305887,0.12296343952493617,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07597547753172064,0.10204871076474344,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023815937692101392,0.060290021741339184,0.6930350004135235,-0.14233815803562808,0.0947062826514253,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.058938496515559054,-0.024924868491415234,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0464238345073388,0.06190534305018719,0.45374259389072114,-0.07527389419666347,0.16812156321134109,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0746542563145325,0.15734005060547562,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001601361255550971,0.05231153633089535,0.9755941185816877,-0.101236210475951,0.10443893298705292,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.017727182593728533,0.017373172390622988,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00012146613346779615,0.04342158148445829,0.9977694105153092,-0.08523962845105457,0.08548256071799015,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04667944583595892,0.06213522294208008,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04319626352114064,0.07384118717201567,0.5588826634607991,-0.10196575837987915,0.18835828542216043,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.1252466320807649,0.22029068602757482,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020711580329338414,0.04598776991376964,0.6526847854067153,-0.0696943017950979,0.11111746245377473,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04307002589058615,0.14379664783288212,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06984682788436299,0.07745939087194251,0.36774321341239,-0.0824281046407452,0.22212176040947118,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.13436423516644128,0.2413819266466828,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027308323887409867,0.062419488533682815,0.6619854887469027,-0.09540014693483109,0.15001679470965082,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.047985618323336185,0.13127589348042298,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01951979415239833,0.053429061734258085,0.7150490018385327,-0.0855146849324481,0.12455427323724477,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03190663095428254,0.07978666686741846,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060904457650084724,0.12322682824448696,0.621401230441148,-0.1813432123223525,0.30315212762252197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.05606131687352582,0.036911738736822124,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016041028827089753,0.10013902763914738,0.8728135699515157,-0.2129011319757257,0.1808190743215462,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.22994005158404654,-0.19609521203333208,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04784083655604508,0.04377427716554969,0.27509128890079804,-0.038213611157588256,0.13389528426967842,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.036964466571626574,0.0809771715935344,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006799536336249165,0.048475359486760024,0.988815549998789,-0.0946162010596147,0.09597610832686453,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04438164629202526,0.11707817461473458,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019477108680632366,0.053399461521482186,0.7154941767647933,-0.08549918029514607,0.1244533976564108,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.053259466051061834,0.09626750984177686,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024051745867436275,0.04642339570133754,0.6046760477319173,-0.11531401075787917,0.06721051902300662,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.019871613434344182,0.07022609166511884,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0391646248906291,0.07489499991663981,0.6013123619485021,-0.10806905369107683,0.18639830347233505,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01600278604786314,0.10871236850854371,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011361471017736421,0.06876262297474899,0.8688478304347562,-0.12381676438873536,0.14653970642420822,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.022616725927612834,0.11894600015186417,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021267321739875708,0.043088494050481436,0.6218765720101583,-0.10597361041948669,0.06343896693973528,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.07637323928065758,-0.05970001795938837,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015718068810405222,0.08113472511134251,0.9845532957048702,-0.16107196112570882,0.15792834736362776,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10928393873049912,0.17438142975306334,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015176491261540474,0.0466379796371633,0.7450392413495579,-0.1068605998300838,0.07650761730700285,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02111564337810089,0.0596433678811247,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06868090167366075,0.04436747252703466,0.12240690780677416,-0.018539689778356266,0.15590149312567778,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03549714345947431,0.15058501671964866,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01850023958546951,0.041817729724792106,0.6584358001508133,-0.10070837342844403,0.06370789425750502,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.050949529305168065,-0.012891018603788142,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04326702640886029,0.044422350431535106,0.3306446277314965,-0.044061447755773725,0.1305955005734943,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.027626686940126512,0.12769651479995722,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024307118224741447,0.05199281259810614,0.6403883029824302,-0.0779038847413946,0.1265181211908775,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0014217790871333276,0.07288050905865233,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0002059146641041872,0.04062102041679371,0.995957916966691,-0.08006147605490324,0.07964964672669486,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08094108990252623,0.11143238498946481,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032665088653217926,0.050247513827524286,0.5160085679904886,-0.06611488742857463,0.13144506473501047,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06687156248613638,0.1377080820186335,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05759700091966186,0.06746836153384511,0.3937844414900964,-0.07503688742488546,0.19023088926420917,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.033783731941160834,0.11362209496062947,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039889006656112204,0.07107770997583493,0.5749712400957652,-0.09984038404491807,0.17961839735714247,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07155540149543617,0.1516769139276965,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018821192221839724,0.04541870684106289,0.6788068252747081,-0.0704659870568408,0.10810837150052026,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.025245206901736362,0.07902778585088364,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017074309630884764,0.06664243545771767,0.7979211432011757,-0.11393591712663875,0.1480845363884083,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06203757920960184,0.12093298210564347,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018541064773188478,0.054957889896665696,0.7360147170572979,-0.08949888856923348,0.12658101811561043,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04456906205696371,0.07016710246995803,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011923688309521955,0.07167744809676806,0.8679633577935595,-0.12898470833087605,0.15283208494991996,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.023841968520795925,0.06875487513384747,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008773368812993444,0.05267444170327646,0.8678010910778322,-0.11232436457830547,0.09477762695231859,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04616461577201218,0.049108077802067586,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005087190280549943,0.031790437976236936,0.8729434033625387,-0.05740861227201818,0.06758299283311806,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.014932989793278145,0.01672882783766496,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-8.810346536002999e-05,0.0392259409425073,0.9982090234359138,-0.0772011228554696,0.07702491592474953,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.048847552322779646,0.0663991073493297,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006753748773970296,0.03580275786509757,0.8504717636924948,-0.06362974477987977,0.07713724232782036,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.013865048014585967,0.016994640387167474,0.9832573347205102,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018117010033921823,0.04820025673703162,0.7072116363250298,-0.07663832898570089,0.11287234905354454,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06670056662281067,0.10494455435168569,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011857496615880739,0.03604989951501739,0.7423877775513178,-0.08272683801389863,0.05901184478213715,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04019084020290109,0.03566853987692001,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04830082151803327,0.04972107242670411,0.3319140736331653,-0.04944424029596128,0.1460458833320278,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06014898925404264,0.1324437186405715,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0024036986845543374,0.03566235507443257,0.9462954467335811,-0.06770378152560452,0.0725111788947132,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.020384450499025434,0.039743041009026446,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0074653264034370125,0.042495698044016886,0.8606394593783512,-0.07607560361701829,0.09100625642389232,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03195629882470342,0.0568577424735288,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03066703859906732,0.05661301202086192,0.5883273415450813,-0.08062666625037929,0.14196074344851392,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06194871980437872,0.10673330630324522,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044256734048316385,0.03417456667074906,0.19605486944296757,-0.022925950649867854,0.11143941874650062,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.028555351326954845,0.07499390891621983,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0314485705792038,0.03289256837748342,0.3395951058396677,-0.03321387478573982,0.09611101594414742,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.034012372968550565,0.03988724753740743,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030236393409148823,0.043427723429782815,0.4866759253854531,-0.05513677542872536,0.11560956224702301,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.030363899622486996,0.09424774910353606,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01664298116665619,0.035287062375089086,0.6374351482340539,-0.05272672316085762,0.08601268549417,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.08220335249564889,-0.039679436252223275,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02585784076695115,0.03253095704008727,0.4271577240244935,-0.03809372446606185,0.08980940599996415,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.021680450052766677,0.0768969850041249,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04757553481185024,0.06337847519180471,0.453296801697481,-0.07701817712853236,0.17216924675223283,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0011546758493428543,0.10464503601527919,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02600674275608787,0.05621828735780608,0.643898702397786,-0.13652447104857712,0.08451098553640138,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.031101190590124835,0.07509153812533002,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019289966187608743,0.047375375665450054,0.6840972306486247,-0.07384376558591542,0.1124236979611329,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06556318772455294,0.11048652547473276,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04855281106415805,0.07444578451620308,0.5146502844846574,-0.09779776936739812,0.1949033914957142,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.135080284325875,0.21698924086544516,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01192379546199254,0.05438075186491845,0.8265546347397962,-0.09498158073164603,0.11882917165563112,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.011072304985834154,0.05778988856760394,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009943410289189464,0.07274597974442798,0.8913466737726615,-0.15295239902974167,0.13306557845136274,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.15116600732193614,0.2177007701321216,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01991248709833509,0.04687503697469353,0.6712096302642311,-0.07223764488803597,0.11206261908470616,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06623912498713068,0.11113800912708384,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034362899517455914,0.056450614111349474,0.5430496978377373,-0.07661155248950308,0.1453373515244149,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08152834765858495,0.14717538464980048,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020941775152054264,0.03522547238046642,0.5525069517544617,-0.04830685138011653,0.09019040168422507,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.001533842476014027,0.036472648111969354,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012114844745684791,0.044797033668728614,0.7869613315355789,-0.07595020717949803,0.10017989667086762,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02523102669287006,0.05214995353123866,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0032432876432340963,0.0516447784355679,0.949956969565402,-0.09828352612362773,0.10477010141009593,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.034426357193109075,0.05412782780723958,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03419881853823444,0.06089617812351064,0.5747060641139443,-0.15391266227507466,0.08551502519860577,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07232912693770366,0.09782940734674819,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009466509914177974,0.056035341792182135,0.8659300094506517,-0.11962459138595816,0.10069157155760222,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.00655066124961964,0.00601572140472284,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00824672738232836,0.04889256576239264,0.8661405441121023,-0.1043630545137432,0.08786959974908648,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.004176575072564759,0.03909846057984531,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002380681407646512,0.053541008859651115,0.9645560647207927,-0.10763523375635045,0.10287387094105743,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.029237694246456926,0.037614249852087805,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008680388335838693,0.04936676219525839,0.860512149814819,-0.10572892302795658,0.08836814635627921,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.006636972242339446,0.04263434676602632,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011672498208333779,0.04764119577270095,0.8065745540299155,-0.0819838007896392,0.10532879720630677,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.01611341922093322,0.02221794369299566,0.9740740620552973,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027127702359946146,0.04489784234016447,0.5460443572708698,-0.11539093081954323,0.061135526099650936,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.020036586411164077,-0.00555212168043075,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03732857917707852,0.042875258301180816,0.3844733333955266,-0.046958516181087775,0.12161567453524481,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10270655537610925,0.15252139194399278,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029009041706671002,0.052557377737419086,0.5812885907009693,-0.07431182176220297,0.13232990517554497,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07928827104676078,0.125242733010549,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05430242044377221,0.043880971319586154,0.21662442261757017,-0.031961773885782564,0.140566614773327,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02297224547904552,0.09374194848388251,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04331937988037021,0.07400119337536665,0.5586147750563419,-0.10215719308469226,0.18879595284543269,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.07747165309388754,0.2216405580911427,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003406599540382728,0.03691206999271915,0.926513823870556,-0.07597085423218344,0.06915765515141797,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.011065269194320661,-0.00278104786085086,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05108052526155118,0.06393838984557709,0.4248176519961908,-0.07461390494117826,0.17677495546428063,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.12111978115751339,0.20931713769348506,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032772975063186674,0.048253179322961366,0.49740870188245645,-0.06208640277097861,0.12763235289735197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05668914523859328,0.0951816428686581,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014656815445246343,0.04682055614319648,0.7544104509893097,-0.07738621442159167,0.10669984531208436,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10272786101414401,0.13683743452629116,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005099511805562987,0.04063822788176221,0.900201710842025,-0.07478987718880369,0.08498890079992967,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04685776705370141,0.07590595776467465,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015800802948033838,0.03676844245771117,0.6676157964988023,-0.05648109897858383,0.0880827048746515,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04050194088497707,0.06470688470906248,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04235888814041255,0.0556630667352879,0.4471096741122228,-0.06706734973524295,0.15178512601606803,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06909506652175945,0.16023306696557962,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03596423788400662,0.057540787063738295,0.5323105753355533,-0.07715335017007352,0.14908182593808675,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.044935510644274076,0.06188921258993402,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04130029071579238,0.047786033325757496,0.3879507724168687,-0.052640739783042116,0.13524132121462687,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.041360652071613664,0.09543158190190551,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02109800621093996,0.04824408367873678,0.6621149967587266,-0.07374349078792594,0.11593950320980587,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04462888010747717,0.052597108654562415,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014853958887206756,0.035044101894877756,0.6718906121016496,-0.05403811722358623,0.08374603499799974,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.023346149615589184,0.08726890938549647,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023511816968703834,0.04122006539540262,0.568726086375005,-0.05752138773519566,0.10454502167260332,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.039497371242605314,0.08480988331467573,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04814824156696363,0.09497128601784305,0.6124483608855874,-0.138552764048976,0.23484924718290326,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.10284936618873629,0.13815329333071255,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06454554168551564,0.043218212931880905,0.13609404764271824,-0.14950684055420743,0.020415757183176134,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05975589560613498,0.0776737970868283,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01239635707205077,0.05611723467060133,0.8252813395650507,-0.09792271498324932,0.12271542912735085,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06693008004106261,0.11803621208088648,0.980554299276661,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010206708340717562,0.03275694671653068,0.755513928509613,-0.05418912275011353,0.07460253943154865,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.023252653613465984,0.006701615889694628,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04532149377203358,0.06685094752943657,0.4981934529348844,-0.08609864018065701,0.17674162772472418,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0791656315258166,0.17014699597139982,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037232932569345185,0.05373754332629659,0.4887925406412127,-0.06840798058481326,0.14287384572350362,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.050800322153762394,0.10163894923925998,0.9408426740082313,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040420093799258296,0.04568083418851494,0.37677214567821327,-0.049382393225803005,0.1302225808243196,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03981315289403399,0.14388042307004567,0.9168661227448366,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004805706208870501,0.04583147779631352,0.9165422266925745,-0.08529292625387944,0.09490433867162043,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03626720655044344,0.060003353053178006,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00010587668462045514,0.05309253392374916,0.9984098531250981,-0.10426703316941718,0.10447878653865808,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09025651706618346,0.16314940000009095,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02453148711817832,0.03632484858220516,0.4998494536365752,-0.0959413420702348,0.046878367833878165,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.03551305013957142,0.0032910255064567276,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003082620019978909,0.039787504284415784,0.9382824676789481,-0.07513435873561364,0.08129959877557147,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.06619880756899796,0.003949454769667074,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020521046391184298,0.06875619315721236,0.7655051185606689,-0.11464454884318548,0.15568664162555407,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08447568989723384,0.1434842578219763,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0018659704292533694,0.047960968563373174,0.9689845821860873,-0.09241895964333624,0.09615090050184297,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.055582048449694534,0.109243442141093,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028979756849577258,0.04126880045756916,0.48294765549856566,-0.11010876824933993,0.052149254550185424,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.010359625353158802,0.007473545330928039,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030630860068195546,0.04284675209200203,0.47508883808019653,-0.0536001958474915,0.11486191598388258,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05602281884481476,0.07970962610757874,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020607408673476785,0.031745058820336056,0.5166090903545356,-0.0830140017986912,0.04179918445173762,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01698888644694714,0.008582048028515601,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00853772839464855,0.04444334964972361,0.847757798831833,-0.07883202745961328,0.09590748424891037,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0004120043581228993,0.009172132318551547,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061140071279218035,0.062085919855954005,0.32533012077105894,-0.18319279013488832,0.06091264757645224,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.10149910951390852,-0.09702938676273394,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02028582994725927,0.04459873761860175,0.6494605588854931,-0.06738939813199396,0.10796105802651251,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02120797792116819,0.05509467169391549,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043145776377564775,0.05645458165063863,0.44516169208236,-0.15412802804278014,0.06783647528765058,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.10227472588387865,-0.0465393537190088,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006252150719196767,0.04425885129732883,0.8877325385857877,-0.08075490574063843,0.09325920717903197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.012887384664265861,-0.001887026423648075,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041177623513438275,0.060272716378898236,0.4948803416341184,-0.15966582379989563,0.0773105767730191,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.09616662223314648,-0.05339383275766096,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03023474585071078,0.04064391531593106,0.4573743818095872,-0.049665823888102166,0.11013531558952372,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.032626447822361314,0.0426831985888557,0.9362139873142092,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044976144850677836,0.03475898460074197,0.19642615908965444,-0.023355428314797068,0.11330771801615275,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01396529768195864,0.045433517164302537,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04167882589920513,0.04337366071295464,0.3371661637507516,-0.043588062777355316,0.1269457145757656,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03921902930042358,0.08332345204972365,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02348564692604167,0.04698099572060931,0.6174206167245145,-0.06887278596100967,0.11584407981309301,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.045111213338412844,0.09244716561549034,0.9570174945596325,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010490349558143522,0.05743348456263571,0.8551628090901902,-0.12339699506631358,0.10241629595002652,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03809442918140002,0.0866532794012141,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017527431677299508,0.058333085456104404,0.763972447958355,-0.13220257373327926,0.09714771037868024,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09105410269863688,0.13407487561875872,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01240974978894899,0.03274086126108275,0.7048656312960232,-0.076773958998748,0.05195445942085003,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.02273638988174232,-0.016841400935344378,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03523383111247017,0.04603597490917617,0.44450858276615957,-0.05526681566658417,0.1257344778915245,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05370134648149714,0.1315728206805554,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02331801821390751,0.0476660738126337,0.624969590278745,-0.07038718772497311,0.11702322415278814,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.029305138811762377,0.08420675571354846,0.9595394253172342,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02793217512279121,0.053907323429015996,0.6046367266907186,-0.07804250329074609,0.13390685353632853,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06528470375901906,0.15338585833125795,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019886507142061978,0.05063941358391172,0.6947427291859682,-0.07966389210325844,0.11943690638738239,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.034329938183146204,0.07942953672957813,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0061992682029154275,0.05380629980404983,0.9083324563362247,-0.09957681110595558,0.11197534751178644,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.056810520487584705,0.09683116223061956,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03507221463586961,0.041098272461677646,0.3939586253362827,-0.11586599051705003,0.04572156124531081,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.02562614336796799,-0.008135183507594257,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0038477769816789333,0.07010683591370978,0.95625769753917,-0.13397300353488842,0.14166855749824628,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.11672174902395578,0.16906938498760482,0.9956418681880812,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004242341885330039,0.050400457299415516,0.9932882357243373,-0.09865640856001523,0.09950487693708124,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.030830830866331753,0.09402235161315257,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011019311503563948,0.07224689773152061,0.8788508063491673,-0.1310085479125193,0.1530471709196472,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09247993653342881,0.15652208374211582,0.986191362849829,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023345725287783073,0.05064250087294173,0.6450539124521908,-0.07621074316003737,0.12290219373560352,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.008482999352326642,0.05971768900256882,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0037180175994914015,0.05580441985302583,0.9469125964011637,-0.11342213703635544,0.10598610183737263,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09225591192534872,0.16303807589829544,0.9933384683801291,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007623145622169107,0.04932895129824981,0.8772637432779989,-0.10459734908438857,0.08935105784005036,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.022069674733858628,0.045562927463901406,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01753446117245943,0.03674919746348512,0.6335220607975295,-0.0897785299820821,0.05470960763716325,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.10686590680721145,-0.05899279951905918,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028672552502013435,0.06385039524600979,0.653630956039414,-0.09684889193926279,0.15419399694328967,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09168356231168638,0.06501295443826015,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003964608434709848,0.049267379549525134,0.9359023943926925,-0.10081776997061204,0.09288855310119234,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.010351096589851687,0.05263637330890759,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012935788830548578,0.06509890095161516,0.8425899740599183,-0.14091163060103404,0.11504005293993688,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.11555799939301703,0.18848276574494433,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010753113358885277,0.02990110510773381,0.7193177444082308,-0.06953473701293339,0.04802851029516283,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.05666867620561762,-0.07627183804124502,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018487270325866337,0.03931963766990079,0.6384814305186097,-0.05880994445593246,0.09578448510766513,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.023607649907223104,0.041740175986440954,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014691167319721378,0.03315465757280007,0.6579237850187465,-0.050486510789543484,0.07986884542898624,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0490203030358491,0.1011182623182704,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024626032409955503,0.04859919716429227,0.6126306229419736,-0.07091357080228246,0.12016563562219347,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.027257080405057765,0.05236236871951832,0.9552369178668337,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0014974513073059148,0.03502464267684774,0.9659186316693512,-0.06735637055078567,0.0703512731653975,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.033822642476099195,0.07591469717031785,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04884829924947298,0.03635267309098285,0.1797906883508391,-0.022616255012105208,0.12031285351105117,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0230130964485374,0.07833469787376147,0.7995397670190257,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038487790770219264,0.04588583128421136,0.4020940109238441,-0.05171769347136574,0.12869327501180428,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06450163341154508,0.10342823988923733,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026845521648113588,0.06747933319668971,0.6909637660163993,-0.10580993553657746,0.15950097883280462,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08142829202825957,0.16663998230048874,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017660980807222566,0.05131787520601501,0.7309139493918246,-0.11854514599833324,0.0832231843838881,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.039229965602519436,0.056759557127808245,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035800203187149895,0.043573554792594005,0.41178814937059705,-0.04985965085031269,0.12146005722461248,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.013135548631129824,0.0501362124951342,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03447777754972815,0.06679935469283212,0.6060401360512199,-0.09684093169997567,0.16579648679943199,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04988287565286036,0.15203397682527248,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023884203935297298,0.05095723368869983,0.63952982409701,-0.07629098766207945,0.12405939553267406,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03181668485728567,0.0972913730194336,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004627480908696069,0.041509894219914925,0.911292029141284,-0.08623045080439012,0.07697548898699799,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.03205644918171856,0.023433258931987565,0.9891749114349121,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00030835963750853865,0.06803914754795402,0.9963861691532387,-0.13406433790306233,0.13344761862804527,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09338116338764377,0.12781574738138113,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020282076145726566,0.06258798918784989,0.7460629970241641,-0.1433217970004671,0.10275764470901395,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.044603553509393996,0.02364998477714354,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02946317271955563,0.06115410242628197,0.6302197058987116,-0.1496840615720232,0.09075771613291195,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.009794446813052615,0.01601068048439594,0.9602080663001867,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009070102855251687,0.054331325097008755,0.8675005347291116,-0.09773810684038504,0.11587831255088842,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.026656931023543322,0.09286713626874439,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01855093205646606,0.05302311075267502,0.7266227613751548,-0.12278736512477127,0.08568550101183915,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.08724520618090711,0.11950918707194287,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0006394924354646208,0.04467021057092832,0.9885850716645761,-0.08717624202875222,0.08845522689968145,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.051134907376807565,-0.00884580407694246,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04720444342580499,0.09518765938250762,0.6202287541435572,-0.13992192364900538,0.23433081050061536,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.16429245905011272,0.20050997399179368,0.9580596405456464,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035813345211460644,0.05595605708684405,0.522519229850069,-0.14581556342354143,0.07418887300062016,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09402213893779367,0.0976468764622889,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037046309210464215,0.0542187547975689,0.4948258383114704,-0.1436332205643689,0.06954060214344047,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09400274172931496,0.07885735261330461,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029885689370636962,0.04161427094546061,0.4730749901076333,-0.05192247138262447,0.11169385012389839,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.06239092365798002,-0.005386829191139057,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013291799552836592,0.04581970286614922,0.7718972247620258,-0.10336728405797838,0.0767836849523052,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.0634793302204171,0.08093255715991127,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028342606955765022,0.03921890317198593,0.4702974004228906,-0.04875657710696583,0.10544179101849588,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.02396496164944165,0.026906751214725865,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027593303627552888,0.04271941448715351,0.518699098010051,-0.056387423374261406,0.11157403062936717,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.047305773282939084,0.004588633113278378,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020077146585731967,0.04725627811188895,0.671167880057781,-0.07282245512650105,0.11297674829796499,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06561578972407271,0.1230687691370234,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025832279465305943,0.04354223731855833,0.5533336350274034,-0.05976600855424767,0.11143056748485956,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06427439759842324,0.0629491108413764,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02128979057385091,0.04909097561231093,0.664752646468226,-0.07521658411885411,0.11779616526655594,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06617637609013291,0.11071180895561981,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02373693122745774,0.05045805696785758,0.6383030704038097,-0.12293080731707348,0.07545694486215801,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.0354945878173488,-0.013875692053518036,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0499654486686429,0.07400886789378698,0.49998169148432237,-0.09552621138607346,0.19545710872335925,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06206676499710446,0.17813562933968075,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009669482576827704,0.04961914002737546,0.8455897573591649,-0.08787519360212417,0.10721415875577958,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.014523228004561467,0.05297507001277086,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05674933826581416,0.0493446510411938,0.25080091411532945,-0.15375440534922336,0.040255728817595024,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02995469072161203,0.0026183768666353992,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016349186872287917,0.06594275135206301,0.8043148379766867,-0.11328555333960041,0.14598392708417626,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.039026184885712925,0.1334587571237317,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028447878594181065,0.046893826665122706,0.5444284972733051,-0.06373919144205152,0.12063494863041364,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.057257015380193385,0.10676080269659032,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044595683922255186,0.07027016177548309,0.5260286462850656,-0.18273754151290195,0.09354617366839157,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.11288208811732921,-0.04318990194052467,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04244347380671798,0.07772693340419591,0.5853276907070348,-0.11035741200291624,0.1952443596163522,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.09421825543526123,0.16402629972209365,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035661221341121284,0.043256188526554,0.4101892232084784,-0.049374732531326036,0.1206971752135686,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04160091267430385,0.0689303041105774,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00324110900824299,0.04638206675841497,0.9443250307524438,-0.08793990863865686,0.09442212665514285,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.05195715408791924,0.044145320409037334,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06291514285144029,0.04800279531008144,0.19072049192773316,-0.031452013081190944,0.15728229878407152,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.025369060072137257,0.05479686082869701,0.8119345039490624,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05523356253602516,0.055087696082466324,0.3166324152113489,-0.05306157262440012,0.16352869769645045,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03684920735767582,0.07899099542608906,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06490740670113743,0.05192106357978005,0.2119822215494196,-0.03716254717073954,0.16697736057301438,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.006763403778514132,0.039808785202705255,0.8272946081671145,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03175505975711581,0.04397841485102179,0.4706762669394875,-0.05470069568604106,0.11821081520027268,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04138241671504359,0.06948094395091586,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030463597278825114,0.041530219562295655,0.4636626831407378,-0.051179329555656294,0.11210652411330652,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.03654359260901541,0.04667684835298541,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030581073608019458,0.0481054440960528,0.525326798337554,-0.06398787628118206,0.12515002349722099,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.040744563030697935,0.07429873856852913,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04733906892148687,0.032881106009309664,0.15072739986581463,-0.01730084294144249,0.11197898078441623,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.031090723076449178,0.07096644885016308,0.7683177847971997,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04043823178211677,0.04622065999296065,0.3821520590512574,-0.05042548148061505,0.1313019450448486,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.060965636064453134,0.09799486546432346,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04967229452286319,0.03482105131102681,0.15449775658332476,-0.01878129359798754,0.11812588264371392,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.01943600336980917,0.05986794045590383,0.7729635971926234,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01468931591992065,0.032534073853917524,0.6518680802494239,-0.04926837655745035,0.07864700839729165,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04416521558001868,0.054064235951715015,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0045423374807742455,0.06401736548655164,0.9434689498207491,-0.12130734840193345,0.13039202336348193,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04698890884304736,-0.008767520464479463,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04024885944500887,0.04889497861509336,0.41089839518570337,-0.055872211036154244,0.13636992992617197,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.009197708397584842,0.03531515760759599,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02626453092745291,0.036904402568504954,0.4770679056785674,-0.046284650620966275,0.0988137124758721,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04175826902046597,0.05505064520854077,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049011946524951375,0.05217208991134038,0.34807351112472784,-0.05355149196215539,0.15157538501205814,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04468527854588348,0.09020608933670156,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03298552560809235,0.03949095064943774,0.4040617607524323,-0.04464846786646418,0.11061951908264889,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.02789113087602397,0.04644967986755937,0.9235364977981017,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02264481090382201,0.042016632121613294,0.5902198178865914,-0.05995433878260397,0.10524396059024799,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.024035346385505696,0.0513045918424109,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017574905084881482,0.03414413777365004,0.6070260730056176,-0.04954796042029844,0.0846977705900614,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.04508898184030398,0.06911114169931329,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025575575115913872,0.04799144501029758,0.5943830693729133,-0.11992041785818469,0.06876926762635696,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,0.06363344759491163,0.07632854123267532,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01570837402228226,0.047029337834512,0.7385440691920355,-0.07674509307624156,0.10816184112080607,391,19,410,5,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Ovary/Fallopian Tube|lin_Uterus,False,403,-0.03702153585803789,-0.010185703389898621,0.963305304214035,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12780608898173776,0.057164751849969365,0.02723287395860953,0.014614170907690113,0.2409980070557854,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.03718210126665085,0.06018196380958256,0.3910019750822703,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18100942399998504,0.06296272791553714,0.004789733359150693,0.0563369342349857,0.3056819137649844,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04155610622462572,0.07430542101200997,0.12673634468312733,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04443493076750346,0.04621466264280663,0.33825554013820724,-0.047074717020587506,0.13594457855559444,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07679705080411336,0.048026712717951156,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1795446740071565,0.06830361878952537,0.009703761248786006,0.0442966868825683,0.31479266113174476,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.050610248796390554,0.03252481946659862,0.199353905835858,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1049867472942399,0.044936464353230426,0.021146329266789516,0.01600805978138671,0.1939654348070931,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.006151055260059751,0.027090732737966736,0.33504311408065957,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044968237917315745,0.04665229099364994,0.3370497354911862,-0.047407957714200574,0.13734443354883208,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06669524647160804,0.06561247495142752,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12207905398304254,0.05998533526142613,0.0440574651591777,0.0033020990445201126,0.24085600892156497,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.004528506989276245,0.02371739700828566,0.5032059833576297,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03686588634691535,0.039916348893728686,0.35757467542572374,-0.04217247116493416,0.11590424385876485,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08351055158916704,0.06709736731154262,0.9120511198404183,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04236822735010141,0.03640526436846586,0.2468356254038895,-0.029717832127153933,0.11445428682735675,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0274333340025409,0.017011182123015653,0.8552269457897888,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15294112137553084,0.057835707379790637,0.009287039193290972,0.03842064433979675,0.26746159841126493,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04598867961223272,0.0061432243877038595,0.1981734331084509,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11341777677030712,0.04317177147743024,0.00974418184231707,0.027933357402755737,0.1989021961378585,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.003512653149793483,0.07184148577890599,0.199353905835858,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19305551928949072,0.0652844509877031,0.003745715988615551,0.06378578595620019,0.3223252526227812,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.11265788738235559,-0.0018906604599104823,0.10360102270951306,0.9900834052574969 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07321413704796423,0.04684518288091221,0.12073262859133264,-0.01954400378568369,0.16597227788161215,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.019775658830608576,0.03838716640841999,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.066673984800942,0.038245371182760404,0.08386021638707904,-0.00905566995190861,0.1424036395537926,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0032730753766426995,0.014088233188341428,0.6500804664849935,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001077984662233803,0.10697602508485661,0.9919768224682296,-0.2129011987133037,0.2107452293888361,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.025299447928550607,0.0049066141499434545,0.9994099232379783,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05944372885109228,0.11481231226621853,0.6055959884727591,-0.16789611647943106,0.2867835741816156,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.25580916036693346,0.14310705519596617,0.9533164021566217,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026972069260695862,0.03163710331163603,0.39562402655505435,-0.03567255509715143,0.08961669361854316,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0042672098515180975,-0.032255976027813694,0.920957044807631,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10201528390610118,0.046126274401818435,0.028900693523580597,0.010680653663068446,0.1933499141491339,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.024206721863688368,0.08037625928694737,0.4046097093301284,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053688857446913006,0.03907863827611461,0.17206533524167333,-0.023690749374518115,0.13106846426834412,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.013317215845125947,0.0035489532611841183,0.7850787711519817,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06723245733634842,0.04010561203356879,0.09628803661545769,-0.012180660095310492,0.14664557476800733,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.036331023967455335,0.06002602770820493,0.6734224093863465,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09642859716971808,0.06038169523155789,0.1129214466218276,-0.023133190096682466,0.21599038443611862,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.057833158482683014,-0.021507299063984235,0.7080335255008432,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10264888451014585,0.06548304151952711,0.11963817340365795,-0.0270140779106688,0.23231184693096052,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07281439128288214,0.0962287152383524,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0397773253713045,0.05227732641218907,0.4482275247666542,-0.06373700219735305,0.14329165293996204,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07060564559324721,-0.011493269322456846,0.9334305759126671,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20704040461748363,0.0781991166166041,0.009204561646412026,0.05219834346832303,0.36188246576664423,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.020042323574945887,0.06431305826287374,0.1972100984392524,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07566661059092383,0.04102093293816835,0.06758473184292431,-0.0055589336508228004,0.15689215483267047,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08250695386120604,0.05656989770745382,0.5994274875632772,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06727533354929066,0.039863914613441,0.0941026454585612,-0.01165919885064072,0.14620986594922203,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0016574685309536411,0.06883604212802215,0.6707240267079618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0499401847515244,0.039293862896568686,0.20622845458096564,-0.02786558831427169,0.12774595781732048,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09263445897699545,0.018390569336582112,0.8201610583485497,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0832002341405125,0.039282006112765465,0.03625372590341464,0.005417938690859991,0.160982529590165,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01773064104080994,0.09027683299929884,0.45679694638302454,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04975253028542267,0.039638382351366144,0.21187977520924783,-0.028735425710244213,0.12824048628108956,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03095589495955579,-0.0019299442665656657,0.8272946081671145,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11700586457635939,0.03748638207247467,0.0022602929183665357,0.04277908406699425,0.19123264508572452,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.03382158898051297,0.053751070844252416,0.06954343095346341,0.6646053787012689 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05171663155001408,0.03498605190026406,0.14199433795596436,-0.017559245494332625,0.12099250859436078,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.023315842538316613,-0.019194992768783177,0.7607934302264618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09719555601214097,0.058210631509351914,0.09760297634702277,-0.01806730824620653,0.21245842027048847,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05328731829505253,0.025260348036140925,0.6772213442508546,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17976752979329363,0.06517172389207972,0.006726889784272782,0.0507210073681168,0.30881405221847047,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.012337534414817317,0.05135424949914853,0.15751637494854673,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019026560837108717,0.04210212858212841,0.6521532346825982,-0.06433985876563557,0.102392980439853,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03950094997527251,0.005752587712146978,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13669290385632346,0.05971562203496656,0.023838945052736104,0.01845000804418409,0.2549357996684628,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01144534055695184,-0.0065341811492745094,0.3634085581572868,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07043939483178377,0.03642306631118075,0.055497104045933304,-0.001681914270041468,0.142560703933609,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.16398363013028597,0.16153104274795027,0.5506521745982841,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05479895518766813,0.04940460753159461,0.26958600556173423,-0.04302710208051769,0.15262501245585394,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.016366769927019898,0.012863244175419607,0.870012817074135,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048768323381157413,0.039726762547491745,0.22202233814696537,-0.02989463422993628,0.1274312809922511,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10717583669128702,0.18642667052060305,0.8355377918591873,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052847000688417564,0.03559868712161326,0.14031482308112922,-0.017641955282016897,0.12333595665885203,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02325230756039683,-0.006126819495407772,0.7568502146876953,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0500680169822081,0.0335605830051016,0.13837960092422033,-0.016385289278978296,0.1165213232433945,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.008279338193585698,0.010936593177466756,0.7523679946140144,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06358423681325076,0.037235178370144444,0.09031100022666935,-0.010145135276172543,0.13731360890267408,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0015681501292608873,0.014786341531073185,0.6631718036996311,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06999021493682153,0.039733622280086464,0.08072446878010121,-0.00868632562993528,0.14866675550357833,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.011958335833776665,-0.0017096298184885621,0.6398297823258919,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039522607429320886,0.03885573699665331,0.3111395845332611,-0.037415632596193724,0.1164608474548355,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.027687541044374035,0.020299159657400014,0.8977920836150588,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054766334115268316,0.032290109963899805,0.09248696057346643,-0.009171308634031837,0.11870397686456846,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02487903326792346,-0.007764829570274736,0.6674195391201606,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004077546738262283,0.028647238665161976,0.8870549527318783,-0.06080194047909582,0.052646847002571245,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.017510929074419694,-0.02769307801405671,0.9882859306472693,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02193424624145576,0.030027089592476075,0.4665313686774355,-0.037522390150038734,0.08139088263295025,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03262047024910955,-0.0030436714573479646,0.937664825139976,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058374792697931596,0.034583274405027266,0.09404028407578333,-0.010103544677869544,0.12685313007373272,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.012852047282802174,0.006689089951553366,0.6707240267079618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04079606379816671,0.030961358300188372,0.19015382348228207,-0.020510517946017583,0.10210264554235099,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.004570421276150384,0.015194401841069004,0.8114284597256536,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04480411184099882,0.030332351525394263,0.1422887182186783,-0.015256973666144535,0.10486519734814218,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.030090342281181296,0.007932273153760435,0.7607934302264618,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04243020802315263,0.03532878630354614,0.23213257009381436,-0.027524317370779858,0.11238473341708512,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.01838209525183691,0.02441322932792036,0.842940686827401,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09076105439086533,0.0645676232475211,0.16242637489574768,-0.2186113972044028,0.03708928842267213,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.5902533157939752,0.0953478536468251,0.7815068115919459,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1383721492889609,0.05616144961001396,0.01517560689961467,0.0271668698562669,0.24957742872165492,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.21701591152410357,0.06635004186299584,0.26949433460657995,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09851038253796306,0.0756727180527614,0.19550076204341044,-0.05132915712712981,0.2483499222030559,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.028465274896331567,0.008161695048651744,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07967661467603956,0.04896532751119537,0.10633864990929229,-0.017279624278037295,0.17663285363011644,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.026166631652829207,0.10581709524971085,0.6896374207352632,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07091177572360466,0.04530287126295693,0.1201722052261955,-0.018792434065919614,0.16061598551312894,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.042618604799735296,0.0339848362480031,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07621695672614662,0.046586298516783614,0.10447385193324446,-0.01602856721008164,0.16846248066237487,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.002427376589129182,-0.021197833141293403,0.6865177455679591,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07385619369960211,0.05170047348301977,0.15575598781679173,-0.028515907455291326,0.17622829485449554,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.09561365063511924,-0.03474562353864031,0.7751667907772368,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08922268667320594,0.06278071854821281,0.15787975473253646,-0.0350894063660461,0.213534779712458,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08251905739421085,0.09170257389980913,0.780274991675152,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13702698165175808,0.049507759238502716,0.006547080822719828,0.03899667370147039,0.23505728960204578,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0661871211267278,0.005894226138977298,0.1556009807507485,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05559151449878837,0.03786269348673388,0.14467743030305313,-0.019380400195449128,0.13056342919302588,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.019041528445580533,0.0074731844558725705,0.7635967032883216,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0360334200894339,0.036292348905710245,0.32279010088976,-0.035829055493972445,0.10789589567284025,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0014153237994978787,0.007163861413727795,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09064239379050365,0.040010591012726616,0.025292848948505947,0.01141742747047221,0.1698673601105351,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.010152841764908795,-0.010373060073851937,0.37388200177512143,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06322742448633839,0.04856681791954968,0.1954770900667912,-0.03293972567456627,0.15939457464724305,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0018961586871479672,-0.017254501760092824,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0783712845531852,0.053634893338141434,0.14659617259444307,-0.02783116111779066,0.18457373022416107,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.14556446697047837,0.11174088718468143,0.7662201971017615,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09015549533838593,0.050256257092820465,0.07536596615728579,-0.009356913120741467,0.18966790379751333,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06323070031919492,0.04817992262215268,0.6286648421036044,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06127667425014381,0.0425622170683641,0.1525787712443865,-0.023000766507340786,0.1455541150076284,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0965452324464116,0.05752085989709558,0.7692078902000675,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08024517604228056,0.05187254082390181,0.124526247016936,-0.022467635633030378,0.18295798771759147,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.039757688644204904,0.019700258514448656,0.7259506085296737,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06136143041628728,0.04375773374277944,0.1634292400154485,-0.02528325276047237,0.14800611359304694,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.012564052688169647,0.07461601801879332,0.7815068115919459,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051643097788301395,0.04044557511933685,0.20413970672170104,-0.02844318050747624,0.13172937608407903,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08925277185159222,0.04096400683756144,0.8179445630780711,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056746042605589075,0.03767570362210773,0.13467326864657536,-0.017855613480809274,0.13134769869198742,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10149822518082362,0.07328193174915111,0.7465338034333207,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061765990882132416,0.030265849729160087,0.0434848675332871,0.001836585573494455,0.12169539619077038,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.05618324543539628,0.017463595774304255,0.4988191885538049,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05095576047718552,0.03308435268844794,0.12617215935567977,-0.014554562192844643,0.11646608314721568,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.008671451529304756,0.015523044090781164,0.7263564310373228,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013176339738026836,0.03151948203096191,0.676672754144043,-0.049235382736492556,0.07558806221254623,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05775780388102877,0.01559557445169986,0.9619695749374265,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14962800747544283,0.0749024225797406,0.048036765171921486,0.0013137297812899906,0.29794228516959564,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.014087823803098639,0.01787023284225461,0.5195038718456577,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02449138306137992,0.041688572555023666,0.5579915667050603,-0.058056154303199034,0.10703892042595888,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.13382015312438333,0.07481980457285811,0.949991921327294,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15990877340973647,0.05034028250746128,0.0018985579085601513,0.06022998623746216,0.25958756058201077,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.13616122656106533,-0.01972092884925846,0.0615132762373489,0.5878636369873123 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04920792112389874,0.03469804771781686,0.15875298133478769,-0.019497678874374078,0.11791352112217156,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0031433237789417375,0.00937506051644753,0.7804909419375794,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06244451276544063,0.028742897105722462,0.03179898629459597,0.005530705758274176,0.11935831977260708,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.08722353672153757,-0.01826205119317403,0.42710719662690827,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06579772603727013,0.0333256654437929,0.050654117607343875,-0.0001904199897986153,0.1317858720643389,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.01893044080384671,0.00509427596871467,0.5297659888894541,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03754210861293996,0.03124863166637693,0.2319816718592684,-0.024333303088134778,0.0994175203140147,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.013104155856923583,-0.013450599156777564,0.842940686827401,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08363869760968048,0.0385549734769989,0.03204551364002406,0.007295999392267022,0.15998139582709395,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04933893413184212,-0.0016272753921983461,0.4282445913712306,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03634467894195064,0.02759523914082403,0.19034792843740767,-0.018296650670741106,0.0909860085546424,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.02925224357881533,-0.018726702201467722,0.8114284597256536,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0455422694098086,0.03280972995173234,0.16770837288146442,-0.019424272813187232,0.11050881163280443,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.030285400083312212,0.011688795283206236,0.7842677313995,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015682457170396305,0.0285853243370791,0.5842946548930825,-0.040919340017051324,0.07228425435784394,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.027487518180551077,-0.017508105715379096,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041573759076138805,0.03661170232916751,0.2584343444869729,-0.0309210681815915,0.11406858633386911,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03307174581764456,0.021115261847066538,0.8664830381179188,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05171411811332291,0.03368549077105399,0.12738812944841582,-0.014986517999790464,0.11841475422643628,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.001388888407926135,0.03259075705633341,0.7274870299003775,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06701712504520206,0.053671811864869176,0.21424526336247454,-0.03925842299598524,0.17329267308638935,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.045276455121813296,-0.03283588357885571,0.8289622204693651,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13112620825264165,0.046961282909508406,0.0061009939126904205,0.03813817776671735,0.22411423873856595,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04361900783477652,0.09826252515835024,0.15040276297806385,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08748409290855774,0.0417936945313472,0.038452055220090514,0.00472840353165091,0.17023978228546457,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.017839604756416005,0.028403666030887995,0.4724959974258181,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024808040146153953,0.03942504005168652,0.5303943024644922,-0.053257476788280855,0.10287355708058876,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.011530203401973985,0.012745611808029252,0.945915518526879,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09635214978541623,0.048422162738484355,0.048901977158013386,0.0004714313306634077,0.19223286824016905,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.007721435726815179,0.010122902598364516,0.5231588877093131,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042645181701973345,0.03353758836040847,0.20600776177027613,-0.02376259286609772,0.10905295627004441,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.007069439109634591,-0.006224215061693092,0.8201051218317211,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09310196076683888,0.045464978222810815,0.04278308643146202,0.0030767630061401263,0.18312715852753764,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.020863969945785682,0.029778205026131817,0.49583625418844224,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05352182187799069,0.03748181357729385,0.1559279715446535,-0.02069591255463145,0.12773955631061285,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.02672242195866878,0.05658682990459567,0.7755364900510398,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1245714526695052,0.0475538954534886,0.009950059488502033,0.030409990158477215,0.21873291518053317,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.03011716915362773,0.03079227951661269,0.20252198005058755,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03668774959885253,0.038478691334572296,0.34229166229292474,-0.0395039023577685,0.11287940155547356,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03682148414641259,0.0899181655719874,0.9045618832985359,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05413766471820621,0.040953367535023044,0.1887255153460271,-0.02695409327712172,0.13522942271353414,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.023391218010005297,0.04861207790166793,0.8085168201280608,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0977979075065615,0.04477870990517315,0.030921606926611667,0.009131589556812175,0.18646422545631083,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02496340637187346,0.037309072845245025,0.42002168600416523,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09042466076723722,0.03759290854995397,0.017696641528456986,0.015986947192979217,0.16486237434149523,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.02419527196818616,0.04637201970270212,0.30274987166571454,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03612757541651832,0.0367303211342447,0.32731273101904024,-0.03660212892248713,0.10885727975552378,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05529715624271096,0.036388904706234286,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04080227722870851,0.0328881060067649,0.2171794311534353,-0.024319457411172057,0.10592401186858907,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02688695566892628,0.007873712025226347,0.8308625663641223,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08340319138300856,0.03730589155868323,0.027239114666225177,0.009533800117697902,0.15727258264831923,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.07035393088516964,-0.002234304514581057,0.3910019750822703,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027767828158087798,0.036012463461470204,0.44219870331864897,-0.043540446291765414,0.09907610260794102,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08289554872695289,0.02159814482301235,0.9330352189956562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035590091155367126,0.06267103094874775,0.5711813297436172,-0.0885048094817387,0.15968499179247295,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06301722687208203,0.023484064819094465,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035025581615125104,0.0385948201262546,0.36596583931569726,-0.041396016947555556,0.11144718017780576,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08694201138746924,0.0330729033412825,0.914684777397777,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059854876424277136,0.05997756501750882,0.3203263993495182,-0.05890669265522482,0.1786164455037791,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08412204319574004,0.061102678232493636,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042674686911152435,0.040618421753603536,0.2955602329895858,-0.03775384498377732,0.12310321880608219,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10162549687033018,0.04180461906027006,0.8831753988928314,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05005944372335527,0.0656264085803891,0.44709558426343865,-0.07988739979695575,0.1800062872436663,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.14463899473440028,0.09248928173819895,0.9330352189956562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024335624577689882,0.027379454237009528,0.3758887054668796,-0.02987842937362417,0.07854967852900394,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.023416887209407242,-0.01175387820461394,0.9164018869766861,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013085141789468886,0.02823685788038516,0.6439195070700432,-0.04282665701014046,0.06899694058907824,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06901088706571389,-0.006551836105297318,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009891003982159197,0.03057270950786883,0.7468663289677329,-0.05064601433638005,0.07042802230069845,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.034290673889521,0.018601476177610578,0.963305304214035,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02593015774690954,0.03445298774484289,0.4531619199765866,-0.04229019902916056,0.09415051452297965,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.010875758550196075,-0.004767648447982224,0.933731420853472,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07914195392426518,0.05893131638159603,0.1818432162918887,-0.03754793836055499,0.19583184620908534,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.010753817183529897,0.04704370759082927,0.8014130815101496,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0919587180433925,0.04928432172781414,0.06452015424152484,-0.005629161319591805,0.1895465974063768,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05628502668878988,0.075699314327893,0.5880149074273526,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03044247871646253,0.03277987118918992,0.3549274914090753,-0.03446494017451283,0.0953498976074379,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06471096923894641,0.04974185999249874,0.9103116080146171,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08051162579391895,0.0360859109883288,0.02754733168803249,0.00905791790520924,0.15196533368262866,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.003673511095391142,0.02956500828401709,0.39228691037577734,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06091005780206382,0.035879544662369554,0.09219202518678232,-0.010135024150115496,0.13195513975424314,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09238321387961426,0.06206567291499134,0.6674195391201606,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09863131518980144,0.0403665769936564,0.016017959782733016,0.018701461072921532,0.17856116930668134,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02525253790948356,0.027944203774817915,0.27874836487218185,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07155258254116305,0.03850568999048951,0.06560703802380977,-0.004692529450703337,0.14779769453302943,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07486348889237658,0.03698738331661296,0.59315338021982,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08573552280417895,0.03965847793998749,0.03263206755605634,0.007207775535966243,0.16426327007239166,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02024931078930489,0.014983059836473528,0.43389171232826673,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07522145794743143,0.04986880132077827,0.1341058791358599,-0.02352374938535466,0.17396666528021754,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.016638691878156607,0.02884351885126609,0.7444803357286909,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12441216139470204,0.05486234380420573,0.025150670674546443,0.01577924120755321,0.2330450815818509,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02525394905579271,0.03138652779052761,0.37386895845421286,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09493910775760706,0.04765711657927066,0.04864638102649911,0.0005732571081734639,0.18930495840704065,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.10745964910097085,0.13860747203500004,0.5225371753563598,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2152218041656969,0.07016158397044263,0.0026727225059030722,0.07629486041597058,0.35414874791542317,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.056903727601298415,0.005676777432977534,0.07911164839882295,0.7560459172479591 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1113135605222464,0.053284130508109186,0.03883386755510087,0.0058056602876722235,0.21682146075682057,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04015902187191342,0.08144628896988923,0.47377644413826986,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11401603217361375,0.04685668168214718,0.016449316147411703,0.02123512256506141,0.2067969417821661,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02354550999176434,0.04331173302440623,0.285097536196843,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05227904090556882,0.03828452103523203,0.1746590643012879,-0.023528134465322946,0.12808621627646058,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.07425862157748925,0.036876417085027785,0.7896200758961603,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003082085614328267,0.04016547208437124,0.9389634604852954,-0.07644956069652742,0.08261373192518395,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08074230614613548,-0.007503818419763529,0.992787535469879,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012092401678709692,0.029745127878660963,0.6850805818708395,-0.04680592235810263,0.07099072571552201,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.025797197999261504,-0.04197971894236179,0.9621831471002781,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031974398999114695,0.04397164730858315,0.46855641261511405,-0.055093854402858716,0.1190426524010881,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.19010223337280518,0.05556744543376553,0.937664825139976,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18791294465506986,0.06156257692908524,0.0028007130351922226,0.06601289368532168,0.309812995624818,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.05415872191392642,0.0423049950583054,0.08173551497557302,0.7811214105906662 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022585759233411253,0.03521232198667666,0.5224857019019609,-0.09230967364790243,0.04713815518107994,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08950566770045641,-0.0065676535993588695,0.9438759903131516,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02160067984204546,0.03340268582313916,0.519087683493437,-0.044539974228649096,0.08774133391274001,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.02091823914462234,-0.007905261273311051,0.9438759903131516,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05269419672691466,0.04063677494711164,0.1972390421846846,-0.02777067632421252,0.13315906977804184,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05901200955220777,0.06964631100775646,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0364976353947936,0.038332737000739935,0.3429624694892287,-0.03940501240344213,0.11240028319302933,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.021738014251935892,-0.02130478347342099,0.9046447408422388,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040321333374689655,0.03913113863403028,0.30490472596282564,-0.03716222939896262,0.11780489614834193,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06720489053308012,0.08433220728339734,0.8931120718424022,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02865573032189789,0.030599434825131853,0.3509232199103348,-0.03193420679405132,0.0892456674378471,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.023644450359324807,-0.008033648839730883,0.9088510667694087,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04296244489787582,0.03322963147079211,0.19855166477245353,-0.02283554427112136,0.108760434066873,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.003709167168571216,0.017685088188367837,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11566380938887993,0.05797542198536999,0.04832248785835364,0.000866683479903263,0.2304609352978566,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.05701990180106817,0.017395409524801324,0.5211737888853413,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10745810225298813,0.04332305017562716,0.014522159051372883,0.021674135953831136,0.19324206855214512,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.007160531572102854,0.029350970671562594,0.262949343295113,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039082916022069744,0.030824904989797196,0.20730859011647537,-0.02195347453907106,0.10011930658321055,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06288854320662385,0.03531252914190847,0.8210381131305959,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10587417942929245,0.05866051280733358,0.07362490766799318,-0.010279494731594924,0.22202785359017982,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08647074846708268,0.05114755175826228,0.6234452489529284,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0586960781894291,0.04379370420349533,0.1827058159962694,-0.028019830092149055,0.14541198647100725,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.030571415632477374,0.020434594655737333,0.8014130815101496,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06982165693435503,0.04977547298225261,0.1633003030671443,-0.028738750966849358,0.16838206483555943,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0050318611363599905,0.018377732996453153,0.7815068115919459,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04056899149029801,0.04860352056147912,0.405563452839111,-0.05567083356735564,0.13680881654795166,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03067501970051841,0.06262866977152141,0.9237532919369174,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09783182187829366,0.059155290779730675,0.1008009889246132,-0.019301562084595505,0.21496520584118284,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.20506631119654514,0.05476809813081416,0.6821468457660524,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07766140852255872,0.05614010558233471,0.1691473621467698,-0.03350160760356517,0.1888244246486826,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.15951615472675923,0.07610281596003937,0.7842677313995,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09300176195994009,0.0545753751211717,0.09097268754731522,-0.015062931573394917,0.2010664554932751,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08707481481989252,0.07971463192087684,0.6643433245175604,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12380592698023982,0.04809257534059286,0.01126976842250035,0.02857782449132351,0.21903402946915612,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.009486987477769401,0.017580071181563784,0.22034340329509305,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01656713895831645,0.04579555392811907,0.7181706770999587,-0.10724690963224552,0.07411263171561262,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.16451397987778404,0.02506779284952101,0.963305304214035,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09945609853604673,0.08628988207059135,0.25139237165613854,-0.07140648628874585,0.2703186833608393,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.4241384161116567,0.1563094436889928,0.8586715345122323,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04695760548879819,0.0397637880420646,0.23999185656243552,-0.031778666299523826,0.1256938772771202,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.012599864795493946,0.020110701396133242,0.8466912699522725,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03733004603714645,0.03827773640844673,0.3314186870786814,-0.038463695095086146,0.11312378716937904,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01141189422823634,0.021644573731167138,0.9034998483867911,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02320969154231033,0.050892574953256775,0.6491833347413389,-0.07756268983363467,0.12398207291825532,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1491339525516177,0.05790189803057687,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03343566971877762,0.03625475608178641,0.358268242821409,-0.03835236831862264,0.10522370775617788,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.051844977743615586,0.033506132305764866,0.9129801963134333,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04022174505945373,0.04622859449975201,0.38601816501843544,-0.05131548919685317,0.13175897931576064,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0711992382681412,0.002659536478144756,0.9192918506885728,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03319063691226068,0.05110588238921403,0.5173001382899012,-0.06800411449126402,0.1343853883157854,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.11383869362877753,0.039920308170732395,0.9438759903131516,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04152507411794636,0.03201919175240472,0.19718116946249964,-0.021876123514250813,0.10492627175014355,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.0114430716066209,0.003315721854560427,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019139904093586475,0.03109103320161837,0.5393285568694619,-0.04242344690689491,0.08070325509406785,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.002954627958233606,-0.017257510105628555,0.9471659478826966,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06728029750572297,0.037712023386621295,0.07696339508216293,-0.007393275341900513,0.14195387035334645,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.056062192895650266,-0.012885365707790138,0.6304803200848395,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07618131155033239,0.05692469490304726,0.18335590617539102,-0.03653526979277959,0.18889789289344439,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09723747589058,0.06841428648719457,0.8024330451816867,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12720137870094386,0.06445641636932467,0.05076219736810483,-0.0004287633868191032,0.25483152078870686,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.010126200758124064,0.039167595188387305,0.5301977930368633,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07822947093589495,0.05012664652889835,0.12126511224842138,-0.021026295661626754,0.17748523753341666,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.08817984507776244,0.05020362804644415,0.7228579124835106,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09490907737376145,0.04816069722412057,0.05108282936528964,-0.0004539132483099839,0.19027206799583288,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.17360103225295295,0.10234253506046222,0.5314488853232886,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13601342531346272,0.057253847704212185,0.01911671230132089,0.022645088549438808,0.24938176207748664,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.05608560989363746,0.06673232654003187,0.3154853684987219,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07632507451745216,0.034606221485250915,0.029338328174342537,0.007801299630935829,0.14484884940396847,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.012273735639583954,0.026303188322513996,0.4079068880915672,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1488395731170327,0.07033612301803503,0.036418787038566706,0.009567024620737163,0.2881121216133282,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04865070662967525,0.022690774080269722,0.4574245751774407,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08779948329393558,0.0537161983697737,0.10479524865208986,-0.018563954460128138,0.19416292104799932,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04511688049943638,-0.00296436759348011,0.6874914742151151,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013620878858393415,0.024332227178289065,0.5766765162858098,-0.03455936117050627,0.0618011188872931,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.04550232430813697,-0.04267758538115123,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045992307851821276,0.035684787061996064,0.19995044533979067,-0.024667134599925464,0.11665175030356802,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.15020744766088312,-0.054361684109017205,0.8150559640549688,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008893923021573302,0.036578419432493715,0.8083103603499391,-0.08132284681971272,0.06353500077656613,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1408734563123927,0.04063181030572364,0.974516576191754,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029578376955070748,0.03778946573470373,0.43534939737217915,-0.04524853947642089,0.10440529338656239,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.18601407209575116,-0.08858148476990255,0.9302388919528202,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04312957133395942,0.038914268087286215,0.26995744786049075,-0.12018370876480333,0.03392456609688449,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1521352326696314,0.013972546221921789,0.870012817074135,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03128111996814359,0.030260757952226817,0.30336376583210684,-0.028638203113618012,0.09120044304990518,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.10750208431113764,-0.04941973592367626,0.891229301693288,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001616169316079396,0.0321330082079691,0.9599706490529056,-0.062010396265716056,0.06524273489787485,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.09761121876997562,0.04104501921567229,0.9962057403241632,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02254327227755402,0.02995457457002036,0.45318731123670286,-0.03676977712693687,0.08185632168204492,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.06842933527540832,-0.07301656503737868,0.933731420853472,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00771950287455862,0.03388102899821648,0.8201605147780776,-0.059368318457995756,0.074807324207113,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.06610932700254196,0.042661895432911885,0.9788034269246562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030495251185816502,0.03255654244201039,0.35081727881859737,-0.03396995448046629,0.09496045685209929,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.07613870699296622,-0.05750871934530359,0.9088510667694087,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023190332331236616,0.031054640063528118,0.45668189998193665,-0.038300956621009505,0.08468162128348274,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.04749686977543357,0.05666131179958321,0.9353936944091839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01886792736979641,0.03411403862477452,0.581243478782986,-0.048681276295511625,0.08641713103510444,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.08859458699398381,-0.008709354165835516,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01773855972951745,0.03885043568296761,0.6488010324103114,-0.0946663026244581,0.05918918316542321,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.1887060390817038,-0.01074824147925642,0.9604336667767839,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006628714283144233,0.03588656170913956,0.8537685803055315,-0.07768769068876571,0.06443026212247724,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.037734608861452835,-0.04740572818936792,0.9832743004559027,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0026974217613643867,0.03562182991565029,0.9397659657483208,-0.07323220277541173,0.06783735925268297,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.026056492470300494,0.027368905425737063,0.992787535469879,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018811436977410567,0.033489802138387474,0.5753724420291958,-0.04750171609834186,0.085124590053163,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.1265897212866059,-0.09798494843700942,0.9525219182038099,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023271161606976537,0.03993664587760568,0.9536311432084359,-0.07675143140641852,0.08140566372781383,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.0696653771346848,0.0652883147470895,0.994341785733425,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02199027349036812,0.028695549072835964,0.44499720121173547,-0.034829779682730766,0.078810326663467,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.03071599635834354,-0.008506657392097708,0.9330352189956562,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021998058154894123,0.030428195002394087,0.47112923964221287,-0.038252807009212825,0.08224892331900106,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.01372715841405888,-0.02369754582242064,0.937664825139976,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061919336115564425,0.04897288104160951,0.2085717509532891,-0.03505185958315206,0.15889053181428092,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,-0.08017699185359309,0.07760016716999088,0.82185729615414,1.0 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018703148546763967,0.043655543450756125,0.6691158188978521,-0.06773918764538837,0.10514548473891631,81,47,128,7,log_other_mut_burden|lin_CNS/Brain|lin_Lung|lin_Lymphoid|lin_Skin|lin_Thyroid|lin_Uterus,False,119,0.11421265842977853,-0.01810887324626752,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06645330375137487,0.03327042078504642,0.046317995479147875,0.0010887456761030506,0.13181786182664668,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.054523630027258,0.19829022503689855,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15417755438551645,0.03521766496450837,1.4559359556384523e-05,0.08498735322392746,0.22336775554710542,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02931255788403631,0.27579945694138835,0.0008435926726903674,0.008061958117628295 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029945835763803264,0.025696483384636478,0.24441733356791176,-0.08043029736340683,0.020538625835800305,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.003858743591623833,0.058116790852703305,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2218950002632987,0.03534358011923914,7.353161949937843e-10,0.1524574205519423,0.2913325799746551,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.09054240192152911,0.3686309668092265,1.882883856729245e-07,1.7994147275958123e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17446396113269638,0.02621795687498593,7.38387060233233e-11,0.12295498936939865,0.22597293289599413,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.039324773831599436,0.310491463017008,3.663322802582127e-08,3.500925975516364e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13758930418595383,0.03839079696140834,0.0003711148119261271,-0.21301358251873065,-0.062165025853177,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028737082294004877,0.008428424895246828,0.0156697307290936,0.14975084177720618 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1627100607524552,0.032528267950333124,7.824773545347995e-07,0.09880356935986111,0.22661655214504928,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06034625171327713,0.3136455030057765,6.607771532231105e-05,0.000631484590469606 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0449413635132675,0.026861516851319815,0.09492794796647683,-0.09771470201601157,0.007831974989476569,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014318090296249336,0.10962359125232447,0.6729775750805861,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06753028661204327,0.02179974382779334,0.00205780641562694,0.024701533989284458,0.11035903923480209,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037990772540171275,0.1605347029192082,0.06482090209224861,0.6194736093996419 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2411062568979282,0.034813582216376815,1.3173512493100304e-11,0.17270993479269703,0.30950257900315936,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.07342237086155902,0.37170998238339165,1.0457134217023022e-08,9.993564526727543e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020489787347451965,0.025210948869631742,0.41675147687611536,-0.029040771408282547,0.07002034610318647,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04336751174603947,0.14391322318017108,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2411763725931304,0.03630904532238325,7.961145478546786e-11,0.16984199672315942,0.3125107484631014,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.08400035941978139,0.3711664879981007,3.7173866358061397e-08,3.5525931335228933e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12958709874295213,0.03051121299084751,2.574868327406396e-05,0.0696434038202954,0.18953079366560888,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.026766390642621235,0.22294716406937876,0.0014193961654827758,0.013564736642330252 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16976821771960604,0.028218118793376507,3.4175045799371235e-09,0.11432963831114892,0.22520679712806316,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.003798106902999731,0.25560183051510876,6.028478079009085e-07,5.7612328033875875e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15171485600002838,0.06798750466633482,0.026082794957199555,-0.285286151231522,-0.018143560768534767,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03613347066731437,-0.03958077693509958,0.37989949792706434,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.20868020874161863,0.05391045582941942,0.00012259150417878248,-0.3145951036476148,-0.10276531383562247,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.04143380650205046,-0.06536738868897168,0.005724302118653973,0.0547054110677154 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16462621348180892,0.023168874252973128,4.0774744913453286e-12,0.11910760593453684,0.210144821029081,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.010566603169702964,0.20310220085448832,4.623856073185603e-09,4.41887835335026e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06648381592990912,0.025580902455746145,0.00962237325115687,0.016226429797359505,0.11674120206245875,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.034265089217175325,0.1911819756378189,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1512247150086842,0.02373885507179807,4.2300373311241694e-10,0.1045862976286907,0.1978631323886777,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023883418750316618,0.21729912292268858,1.2914629359409098e-07,1.2342117750762412e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06680828320468388,0.022464292894915333,0.003079408174325907,0.022673927735107846,0.11094263867425991,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.009113974307689671,0.14756389097216516,0.08921292732773375,0.8525807619611617 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1590785167432477,0.03366490872183747,2.9779454726347967e-06,0.0929389300075039,0.22521810347899146,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015227205420875757,0.23802993459741634,0.0002148993741979547,0.002053727836164293 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.096495216795631,0.03136441180185704,0.0022067993889586437,0.034875289294122994,0.15811514429713902,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037875079410328215,0.23534507358301954,0.06869636686099495,0.6565102452826147 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07306632587531868,0.023739403412148318,0.002197611079447646,0.026426831201325794,0.11970582054931156,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.043013067201468504,0.0986121570917802,0.06867967223880084,0.6563506998654062 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20605542077771435,0.03337632632630608,1.3661740678505761e-09,0.14048279593506124,0.27162804562036746,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0798445787094417,0.3746986821531308,2.78068967964048e-07,2.657420395069153e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12347084263659143,0.021436142289347405,1.4590814364129123e-08,0.08135643787343917,0.16558524739974367,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01033623257663724,0.21493633717184318,1.930364740374283e-06,1.84479076128201e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03838802711822394,0.02386273201163043,0.10830274674585429,-0.008493764443303763,0.08526981867975164,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.029685636202366302,0.17050186806751005,0.6975344114730515,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05517576729900577,0.02048814291836496,0.00731394178815544,0.01492384453871877,0.09542769005929277,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.02137840237683704,0.11451891192646615,0.16779788992594766,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020456761425415936,0.024029193125855546,0.39498745116850287,-0.06766558994383516,0.02675206709300329,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03083956027289533,0.11882412464111335,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09774604109597683,0.02300535342704626,2.5567039191308962e-05,0.05254869388357905,0.1429433883083746,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.001565029261068616,0.17039263123614234,0.0014192388608434304,0.013563233329825099 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08535890102170993,0.01902349903817087,8.941012810073104e-06,0.047984483195462335,0.12273331884795752,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.058814397818903554,0.19939813450646773,0.0005501841836151961,0.00525794259348108 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18437363100452456,0.030448354793817845,2.7278497503462063e-09,0.12455343010969505,0.24419383189935406,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023031636346318943,0.2735698389689941,5.035737515871671e-07,4.8125008974832605e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1650335021479327,0.03314951389242228,8.793516723926629e-07,0.09990648316649113,0.23016052112937424,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05073553884989345,0.28734287630139405,7.347677447845218e-05,0.0007021951442211301 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15373279874507007,0.03149452939927368,1.413705900816211e-06,0.09185723638676527,0.21560836110337486,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.07037862795217896,0.3008476130068117,0.00011335350950180892,0.0010832849498032383 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11493200362754206,0.025540289079805795,8.430885903689095e-06,0.06475440835148438,0.16510959890359975,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.009295634991888567,0.15599082918143864,0.0005246569175458251,0.005013986290194933 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1549044877124156,0.03513564236302398,1.269516488929524e-05,0.08587543182556931,0.2239335435992619,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05144933988759851,0.25544852661617323,0.0007577008939189895,0.007241116560416711 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05269785460693567,0.024634249627644194,0.03289461475229387,0.004300304998828254,0.1010954042150431,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015362340340122458,0.16017732886473274,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15874546160570532,0.03385287551035475,3.5279863918501503e-06,0.09223658690262143,0.22525433630878922,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01857737499845439,0.24186252479530318,0.00024783323874784504,0.0023684667442277025 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.063586111355754,0.024137491857559493,0.008687607058071563,0.01616451430087182,0.11100770841063617,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.016443826410412084,0.14418106765829422,0.19156173563047796,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07473748070482097,0.020308031854933066,0.0002579681156490204,0.034839412202697866,0.11463554920694408,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.017872889145824918,0.14175540801129916,0.011189895639464063,0.10693842289820644 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12184773077333012,0.022391269275693737,8.220027428868979e-08,0.07785684077509017,0.16583862077157008,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02166701297512344,0.22464440284526685,8.585602332942363e-06,8.204998533480442e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08275693701056329,0.020978209243273708,9.105937155262718e-05,0.04154220800979645,0.12397166601133013,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.007568055008329134,0.15574732682516443,0.004434535529967819,0.042379504790764376 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14652148898613176,0.026571084097721274,5.581536158676106e-08,0.09431874767277117,0.19872423029949238,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03327886111252018,0.22849350199716176,5.953302043391476e-06,5.689389356873803e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10563113185598826,0.022565899068029138,3.667173253794284e-06,0.061297156350158026,0.14996510736181848,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.025463621052983117,0.18560355856620506,0.0002553510639352546,0.0024403123087502776 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.155936614123789,0.026937237410259635,1.2417206814543716e-08,0.10301451162120583,0.20885871662637218,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.018563339101170254,0.2571703565161408,1.7119636479103883e-06,1.6360714922214022e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08203719078644657,0.021229508789773605,0.00012583921731098684,0.04032874744681977,0.12374563412607337,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.005432540032060691,0.12156188798342882,0.0058415889299100205,0.05582628538384818 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13107007987690306,0.025145046057119706,2.714092303402003e-07,0.08166899673686928,0.18047116301693683,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.010854339468345256,0.1939199956832855,2.505170314465709e-05,0.0002394114933257749 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16087865528024764,0.027534836861957984,9.182321724420606e-09,0.10678248214240985,0.21497482841808543,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.020314687983850683,0.23696319343895667,1.3752692424235993e-06,1.3143029084785522e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047057940931907315,0.01855450661435969,0.011504683799722436,0.010604926616638054,0.08351095524717658,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.021041822314595525,0.09551869672372107,0.22274190244438216,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08076566903755363,0.02037456397120693,8.42552770939499e-05,0.040736888561387546,0.1207944495137197,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008819049238123532,0.1258656403460049,0.004206404965860216,0.04019933050437454 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15334223622282062,0.02431665383696943,6.226196107478156e-10,0.10556864952273128,0.20111582292290997,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.016626657775963668,0.2395557129354698,1.6474514900387202e-07,1.5744191887251496e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06575943590437656,0.0215826763978539,0.002432708395485694,0.023357143671830297,0.10816172813692283,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.04816056081288984,0.06791583079493167,0.074183466974028,0.708948789061601 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047786380144868,0.025910518751922094,0.06572368264981426,-0.0031185849189235212,0.09869134520865952,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015849658447032237,0.21410659069083482,0.5935319600389369,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025253615005635645,0.039673015663301,0.5247087047415155,-0.052689767589349144,0.10319699760062043,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.056275542427119025,0.1724225202195127,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03309862004631576,0.02876243338065754,0.2503728996706527,-0.02340934416738373,0.08960658426001525,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.021395847014828724,0.12408930904826908,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0772820099660561,0.025448884663919705,0.0025142491853484663,0.02728399189730587,0.12728002803480631,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05211834356108214,0.19247966905992,0.07588634993648716,0.725222722639978 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3570046002049033,0.044486788670350406,7.08620045345941e-15,0.2696038636644019,0.4444053367454047,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.044399462676548394,0.4952263920282604,2.8125129599780394e-11,2.687832934384927e-10 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04332593956845938,0.02758541272439645,0.11689575959227116,-0.01086959717283039,0.09752147630974914,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03243742421173477,0.1639739286206714,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14093363529161526,0.035064777934210936,6.723450437900959e-05,0.07204380283396897,0.20982346774926156,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.08208079846084104,0.27096535793565074,0.0034432741661972782,0.03290632198933622 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11251108207764215,0.025661473983998494,1.4141262794564071e-05,0.06209540151378101,0.1629267626415033,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05688453783071951,0.23307680822617868,0.0008253922357591882,0.007888022087821692 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19001131863867488,0.03274422164897249,1.1481997600818297e-08,0.12568055494223823,0.2543420823351115,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028553410974387548,0.25553777375259845,1.6571653991871936e-06,1.5837024757010408e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06874083530807307,0.01919055217265636,0.00037375648481590275,0.031038217415427727,0.10644345320071841,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.005916855002413331,0.16440378797828517,0.015697772362267916,0.15001882712074913 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11832540592398891,0.02028141365934767,9.63466995079013e-09,0.07847963272051686,0.15817117912746095,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023904823334604842,0.14245787189244113,1.416296482766149e-06,1.3535113919127022e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19668379328424387,0.026652050656712205,6.521393057028168e-13,0.1443219814444986,0.24904560512398916,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015097640067063831,0.3058277213157,1.1689901273396441e-09,1.1171682438252157e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11499828382082028,0.026681793228263286,1.9612564526834792e-05,0.06257803839353429,0.16741852924810627,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06447863419408272,0.22834680380662106,0.001120032641827443,0.01070381066728832 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07665000185219624,0.03049522076596994,0.012261957259655235,0.016737725970450243,0.13656227773394225,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02569310045742249,0.17942986561632462,0.23120051479131415,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04743714251383534,0.02374328202171552,0.04625816529544819,0.0007900277498548713,0.0940842572778158,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.012487021741198943,0.1738086739034822,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11126413442464811,0.028117693230124127,8.66704881550536e-05,0.056022855573459644,0.16650541327583657,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.032789172759671664,0.20341831554758621,0.004273231894253513,0.04083797509586717 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.067741708350862,0.029041419889140566,0.020059346250232202,-0.12479778194838245,-0.010685634753341555,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.027981629963576636,0.12134583645044221,0.3249614092537617,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14039805019166213,0.022383961957029498,7.619507947811903e-10,0.09642151647879318,0.18437458390453107,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.017610936038138323,0.24144516906030106,1.884719935443419e-07,1.8011694120748909e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01611438090647083,0.02693503105717566,0.5499274212687666,-0.06903214870901449,0.036803386896072834,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.022162964961066435,0.15139452604784115,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17046985707619747,0.026917443414864132,5.295073457938397e-10,0.11758664274307659,0.22335307140931834,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028765443219770398,0.23252850037614137,1.5011533253255355e-07,1.4346064906321109e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15904604154346624,0.030276210703206765,2.2032861054303087e-07,0.09956404263534321,0.21852804045158927,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014677605875729765,0.23942138732570076,2.082105369631642e-05,0.00019898046568999015 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12799500572500072,0.023649464960927947,9.613142991175058e-08,0.08153220815850688,0.17445780329149457,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.002574514084873422,0.20117305351355022,9.910276501811378e-06,9.470949271870255e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1336074844702463,0.03912539712668913,0.0006892283373501039,0.05673997776726558,0.21047499117322704,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06518370442462469,0.27341493270745715,0.0269512046398282,0.2575644503086796 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04744796751907992,0.020276405769311407,0.019666973542873657,0.007612033040558928,0.08728390199760092,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.006908014887481515,0.16420851935517342,0.3212272345336031,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24336765181887246,0.03360810359716896,1.655489739379345e-12,0.1773396669740202,0.3093956366637247,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0559396847483844,0.3518077481566202,2.1902129251988734e-09,2.093119753556993e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13065976367967605,0.02328964510720264,3.3249286902792035e-08,0.08490388430569376,0.17641564305365834,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028730693391051085,0.20324191509586104,4.060505222067126e-06,3.88050111107727e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1681211234399277,0.02856619527989414,7.220730337417162e-09,0.1119986973838849,0.22424354949597047,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03275670677443124,0.23836296891639133,1.102272258046489e-06,1.053408009134766e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1698815819543985,0.02661450402515975,3.917585614684531e-10,0.11759353590783322,0.2221696280009638,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.006219482080187152,0.23340692802348495,1.2439117843746322e-07,1.188768588478883e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13567129977946787,0.021897424513081784,1.199554042997036e-09,0.09265063930956699,0.17869196024936876,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008561678011220552,0.16753649808536164,2.505805261397492e-07,2.394721732692674e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1635498553483666,0.02825880238024992,1.250867870733214e-08,0.10803134714387536,0.21906836355285786,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.018481247412647225,0.2371941640860519,1.7119636479103883e-06,1.6360714922214022e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20355196078109225,0.02980255951291143,2.4337950063685817e-11,0.1450005182051391,0.2621034033570454,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0066462255212138945,0.23896107908800526,1.3799617686109859e-08,1.3187874127675634e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15268339037443673,0.027384051234213037,4.011220877198527e-08,0.09888345743101454,0.20648332331785893,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.007776010735137999,0.20962505718489044,4.6825104887061625e-06,4.4749325909757076e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17973523418107604,0.027353008587969907,1.2407489267216174e-10,0.12599628901013438,0.2334741793520177,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0015607198982553192,0.2051158592786602,5.274849825154007e-08,5.041013245355577e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07309500837568678,0.022037314208085673,0.0009754836887911453,0.02979951434860638,0.11639050240276717,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02300710535593036,0.16456450911666537,0.035520135420294086,0.33945511069653705 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05887034190720938,0.02226498734586835,0.00844470821919436,0.015127551041506967,0.10261313277291179,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015820063903840734,0.12101771860290067,0.1877705709914981,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24312355715641187,0.039022674643536134,9.777877102272022e-10,0.16645786364236165,0.3197892506704621,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05401434690390098,0.2767995770606142,2.217622526795295e-07,2.119314274591238e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07253579593091306,0.021463937544672036,0.0007822215608170531,0.03036678336485317,0.11470480849697294,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0635939428504822,0.18588817917751482,0.02985228245079696,0.2852891669464157 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1861291509061148,0.029975888377304066,1.1073922968183806e-09,0.1272371786838457,0.24502112312838387,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028887761334536598,0.2761269531998329,2.441800014484529e-07,2.3335538685533225e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03369698658698898,0.021354556641730322,0.11519349674704236,-0.008257131360549196,0.07565110453452717,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0031675164649778943,0.1041675934585393,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15425665643364717,0.03205815549548001,1.9753487155394145e-06,0.09127376901515628,0.21723954385213806,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05448322411735853,0.24952803579544278,0.00015505603276164812,0.0014818232572164937 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14826637690862282,0.027460730550081955,1.0293351550582701e-07,0.0943157963485784,0.20221695746866725,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.020502036444761326,0.22540851051838676,1.0475464693400701e-05,0.00010011082404444728 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053937840396259124,0.0239362927152905,0.024660111480356513,0.006911528183264105,0.10096415260925415,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037930836029803336,0.15620034798932297,0.3709605300190827,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14305955107930846,0.026661662659981475,1.2273815020371226e-07,0.09067885506764442,0.1954402470909725,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.005468440971063374,0.21923389415925393,1.2332853624266682e-05,0.00011786132408261448 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1461720780084374,0.02804174160909066,2.7127073136566087e-07,0.09108001711202107,0.20126413890485373,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.046660521637537686,0.25362637222931617,2.505170314465709e-05,0.0002394114933257749 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022604500314122738,0.02314541454494456,0.3292173248333484,-0.0680770178687924,0.02286801724054693,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.032203824632245914,0.06738105367590394,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0199946683814209,0.02438103720796512,0.412548870874503,-0.06789474553438786,0.027905408771546066,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.01595484161544484,0.07336668273562723,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18911359845027384,0.032883250158122476,1.5328551015596243e-08,0.12450969312093856,0.2537175037796091,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03329449904151218,0.2810592201575116,1.994721933800049e-06,1.906294969979312e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05949282073250712,0.022032657732649855,0.0071607525408295585,0.01620647502552213,0.10277916643949211,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04256032067179257,0.16102605900507255,0.16523852810786346,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0829662172894264,0.020566749261857722,6.326853819535703e-05,0.04255986098778104,0.12337257359107175,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.024232470215765273,0.1588704185472201,0.003282520628723818,0.03137004941570362 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14186324134581776,0.027803085633802536,4.7451890900012854e-07,0.08724005466225007,0.19648642802938546,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.003793341774292939,0.20803419937095774,4.1808121517223276e-05,0.0003995474777817105 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03827627496221169,0.018112242313370268,0.03506364429578189,0.0026921528913000856,0.0738603970331233,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.017461121746930614,0.08360284599616442,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15654498966540603,0.025109846038647927,9.543438632270188e-10,0.10721306205744427,0.2058769172733678,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.02780263227254772,0.21677385950984818,2.217622526795295e-07,2.119314274591238e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04628165358661065,0.03437709278349911,0.1788083233263901,-0.11382042901189718,0.02125712183867589,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.008537784001010202,0.04553841791740043,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1560977200508657,0.023765917690670893,1.2625616865447988e-10,0.10940613423833537,0.20278930586339602,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.005641329067165708,0.2276598249538891,5.274849825154007e-08,5.041013245355577e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10368560471052948,0.036991903942319805,0.005257669369761596,-0.17636155519443214,-0.031009654226626826,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.009297283494463853,0.007868505715475125,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17688241419779424,0.027137297099549873,1.7195735735030283e-10,0.1235672654736553,0.23019756292193316,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.020839587684420985,0.22666188218303518,6.204534102939563e-08,5.929484180768225e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09395735135840937,0.03638815119369217,0.010099344539658455,-0.16544714216444845,-0.022467560552370272,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.010449619979509597,0.01885125124667051,0.20399134085447534,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14351476995081724,0.022683077817508206,5.493001687196314e-10,0.09895057982807556,0.18807896007355893,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.007435882887253127,0.18290196932434752,1.503567151481529e-07,1.4369133107365095e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1586844214341138,0.023066334037999514,1.7731508748929e-11,0.11336726898354749,0.2040015738846801,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.013064768333935226,0.20232401135328942,1.0915019591215567e-08,1.0431151626392854e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11978736141018699,0.021699863216046632,5.408504644414098e-08,0.0771548387085732,0.16241988411180078,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01172082910059716,0.1781456725394589,5.881193132514947e-06,5.620477068015203e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15441008468057624,0.026025493379957545,5.506817872588715e-09,0.10327923531553224,0.20554093404562024,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.00420287151606884,0.2426095419643088,8.921044953593719e-07,8.52557082459982e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03654587277922382,0.03247917363979853,0.26103163243023914,-0.02726416573311255,0.10035591129156018,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.037686039418551684,0.18182176414127785,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07314928788486268,0.026991488076335158,0.0069539663238359405,0.020120602095093976,0.12617797367463138,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05470386616543508,0.21307854472713836,0.16187854744460323,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07041874893240677,0.019551006072069325,0.0003470857973862349,0.03200796717270789,0.10882953069210564,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.023810706515017363,0.1420518786978374,0.014845987150114105,0.14187857539985768 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09539275252747578,0.02800737803713134,0.000711483407734849,0.04036820384286828,0.1504173012120833,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04033195486847,0.18837148467034975,0.027604320218629012,0.26380607688121777 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1747462988748656,0.027142101390892563,2.803227800230371e-10,0.1214217114248834,0.2280708863248478,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.007672256469149121,0.30427187274268735,9.296830253864751e-08,8.884697385330084e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12358333126470464,0.028708152965176193,2.0060005137731177e-05,0.06718200878520514,0.17998465374420414,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03787984486483934,0.23697117631233441,0.0011374022913093577,0.01086980711459563 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15088732661173004,0.024575406188940625,1.667425004837874e-09,0.10260538345751566,0.19916926976594443,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.021915779297972636,0.24911822650858895,3.151433259143582e-07,3.0117287368902604e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13315102899391057,0.028696166466078383,4.438591889811354e-06,0.07677325572713248,0.18952880226068866,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03152943402027678,0.23815135868034304,0.00029858934255358075,0.0028535273621570216 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05377150548548542,0.027591629748098524,0.051865348799092666,-0.1079792564698548,0.0004362454988839637,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.025673411912654404,0.06376321905961785,0.5339911008653665,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19053094365125842,0.030896464486429787,1.423145226554833e-09,0.12983036639401183,0.25123152090850503,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06454653872049533,0.33286843365726365,2.824231702098066e-07,2.69903217914148e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01691588111046522,0.02431009776666848,0.4868487212074115,-0.030844825240418428,0.06467658746134887,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.04191168405537676,0.1499492827004269,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.25411423697064117,0.03436730406030662,5.914803515077712e-13,0.18659469290914568,0.3216337810321367,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05064345924565052,0.36974847756444995,1.1689901273396441e-09,1.1171682438252157e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030162983697168314,0.02908620577026647,0.30021979356354056,-0.02698107824732015,0.08730704564165678,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.027520108663667706,0.14911373994654506,0.8874303892853559,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15757898373944557,0.027319108776346485,1.3944043602986621e-08,0.10390663965599586,0.21125132782289527,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.040538157048047925,0.26221116680263645,1.876064713906912e-06,1.7928978805899642e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10862388041494228,0.022178707484813348,1.3055300625503785e-06,0.06505059882671768,0.15219716200316688,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.00581403143158095,0.22292961377382023,0.00010574793506658067,0.0010106007924577656 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02608582112190942,0.02734363975651087,0.34053757011941077,-0.07980635986715669,0.027634717623337853,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.04841748871183666,0.02007899703466105,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.4060115955563762,0.05515135215728247,7.363253510579768e-13,0.29765878017404956,0.5143644109387029,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.025054632932434272,0.48047321443114355,1.1689901273396441e-09,1.1171682438252157e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12912750079802612,0.02312515034016928,3.836469822653464e-08,0.08369479520721591,0.17456020638883635,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0038023972135837053,0.22214963684190958,4.54967272797635e-06,4.3479835908109856e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17474431569197763,0.03140797635577072,4.278784382083183e-08,0.11303879931761732,0.23644983206633793,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.07026425718204546,0.3387676469929361,4.922462380431348e-06,4.704247302205326e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010404416556118094,0.021435028261086973,0.627606734142076,-0.052516632649478735,0.031707799537242544,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.01970569380385159,-0.023018567973775418,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13546667664120132,0.021861488696827823,1.1937289605851113e-09,0.09251661728463442,0.17841673599776822,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.014724276794883246,0.16882764334770814,2.505805261397492e-07,2.394721732692674e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031469593935560466,0.021467518571975413,0.14328966967290183,-0.010706454077049767,0.07364564194817069,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.041626304260119484,0.12201143893885026,0.7615412190387651,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17702671446047602,0.02700292442656121,1.3623204018744832e-10,0.1239755603050876,0.23007786861586443,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.010535711737840304,0.20828974002008846,5.407049675039824e-08,5.167352613564788e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009880457886404152,0.02049860189738874,0.6300089743081727,-0.05015292882509337,0.03039201305228506,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03588656988541791,0.09066665863026105,0.96007126858481,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1560504435440058,0.02612567606990258,4.380835273501202e-09,0.10472277078146536,0.20737811630654623,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.016625659962536506,0.22836980586742003,7.361203831817048e-07,7.034878195204077e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11755537116579891,0.02515946426922277,3.8174550106651245e-06,0.06812596136081428,0.16698478097078354,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.023546412041008703,0.2006843857820207,0.00026350398151878053,0.0025182272577804073 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12081835781057858,0.0340950192733506,0.0004311578582067843,0.05383375663077934,0.1878029589903778,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06752432792455629,0.25159670942272827,0.017682532570199628,0.16898657564190503 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1267281902919188,0.02478181968381854,4.4822528037610414e-07,0.07804071794525336,0.17541566263858427,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03487925715477103,0.21829322429310716,3.997766601826421e-05,0.0003820543723452591 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04120079835593627,0.020251894280941023,0.04242843630612226,0.0014130202447617812,0.08098857646711076,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014442790039072027,0.11035889381956443,0.4945623016123326,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14166904086528556,0.0314871634937633,8.460076271839962e-06,0.07980794989469239,0.20353013183587873,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.05539932874696903,0.27243741648187747,0.0005246569175458251,0.005013986290194933 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09620986956555859,0.025043903396361394,0.00013767668249333833,0.04700749582465558,0.1454122433064616,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02147415347815302,0.21155032957936884,0.006280905204782298,0.06002469715657909 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02881963215166254,0.02656557056183956,0.2785031116698117,-0.023372277022283026,0.08101154132560812,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.013117328195169486,0.15899441591278268,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1931758213234013,0.0341331868961771,2.5406877295780022e-08,0.12611623432316546,0.2602354083236371,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03154075270273502,0.3026079701652336,3.201266539268283e-06,3.059352884211042e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09660699967685489,0.032126714166080116,0.0027685085433724987,0.03348941882496992,0.15972458052873986,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.013574879347874979,0.19525056535912622,0.08109380375384094,0.7749887719835561 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08157895394544458,0.029666102808347368,0.006173772870049127,0.02329560031996982,0.13986230757091933,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.043651851862184746,0.20881139200703977,0.15172572458962838,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023940434564693684,0.024731764893672164,0.3335032546018709,-0.024648697900471424,0.0725295670298588,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0440687285786995,0.12047124586488119,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16015158391060758,0.024876927214351863,2.8108330321586547e-10,0.11127725905182315,0.209025908769392,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.051133674108332396,0.26455331133194726,9.296830253864751e-08,8.884697385330084e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06621565842046438,0.024607217705535502,0.007360663371827598,0.017871216936656796,0.11456009990427196,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.012955134747194081,0.09953414442491258,0.1683831292379466,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3617142657207488,0.06788491411903447,1.4923943972867066e-07,-0.4950840069703943,-0.22834452447110326,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.13858426837740728,-0.06480972726155247,1.4808283407077347e-05,0.00014151825221654844 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1780876088242444,0.025891516576369695,1.7875441507407705e-11,0.1272199762852044,0.2289552413632844,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02407577197610953,0.2630299621115005,1.0915019591215567e-08,1.0431151626392854e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17265747164085057,0.025352649980926397,2.7610118630205152e-11,0.1228485205384009,0.22246642274330025,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02770869678644329,0.256126680754336,1.4611274779104567e-08,1.3963550079048083e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015977423570321225,0.028695233104086507,0.5779112482223536,-0.04039851597170426,0.07235336311234672,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.006076467267769108,0.13312229001069062,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13839881551607372,0.02245995651216986,1.4632770257097785e-09,0.09427297949816421,0.18252465153398323,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.014312703323714737,0.23471062798663314,2.8330470805083466e-07,2.707456767670453e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07392904531428178,0.02500999762820237,0.0032616348655423854,0.024793284363347247,0.12306480626521632,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01458982922961357,0.17831629741139257,0.09313258116070308,0.8900396992658464 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03583872900328238,0.027500814496084016,0.19310096429327017,-0.01819060227149647,0.08986806027806124,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.011435300119506308,0.15155389405117572,0.8140390093255331,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12629517777711963,0.027539470865358625,5.697503886830676e-06,0.07218990046875273,0.18040045508548652,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.011309874400878332,0.1688581704964725,0.00037377508969968514,0.003572054637413435 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16933856841988526,0.030327409836010868,3.8401117759437566e-08,0.10975598140344828,0.22892115543632224,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.009803307378770049,0.22057892535406415,4.54967272797635e-06,4.3479835908109856e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13460834837284003,0.024417060727923948,5.6248129661673055e-08,0.08663749779991431,0.18257919894576574,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03922505596118087,0.24937858815788294,5.953302043391476e-06,5.689389356873803e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012073084838746303,0.027464379679816086,0.6604205466202149,-0.06603083464242523,0.04188466496493262,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01118300281632562,0.0850324570804132,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15704235755532084,0.03505804185489466,9.249734921985309e-06,0.08816575910065014,0.22591895600999154,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.06593593739954516,0.31636324828816326,0.0005639715767912388,0.005389704508840115 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06379749558192183,0.0260185764507807,0.014542046070364651,0.01268023552558551,0.11491475563825815,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.02164663230578478,0.2032332284197867,0.262949343295113,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1016552336698751,0.028677354185719872,0.0004292262050341365,0.04531441985124967,0.15799604748850052,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.057279525149231326,0.24419778403328457,0.017682532570199628,0.16898657564190503 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.128230095645278,0.029156751941846235,1.3318998800308525e-05,0.07094743553399732,0.1855127557565587,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03460894368237648,0.2743196263771279,0.0007890015856481274,0.007540247733484313 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06033822490682293,0.019833532073810535,0.0024697455910336103,0.02137237991639726,0.0993040698972486,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.03819256220010499,0.18329066282433512,0.07482763550238472,0.7151049113993448 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021824360484881494,0.04172732124472496,0.6011860954417536,-0.10380372378924443,0.06015500281948144,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.020259181379720742,0.10935066937374784,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20702386474081946,0.03739971102675407,4.9828772205892443e-08,0.1335467182027331,0.2805010112789058,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0555356583945126,0.3237139083922926,5.5709970953573825e-06,5.3240321674397756e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1820264439294669,0.025855600505990728,6.2618830915316045e-12,0.1312293737101309,0.2328235141488029,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.00810476054602821,0.23204083555730243,6.213353497572234e-09,5.937912607478555e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09151555134244789,0.024810928141957074,0.00024988802467748936,0.04277089121583908,0.1402602114690567,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.015077797317815084,0.14451347267953085,0.010898962307087421,0.1041580616924099 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22276461661259792,0.032336394522662196,1.668243339270447e-11,0.15923508834551184,0.28629414487968396,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.018362315138325716,0.29652983920606596,1.0915019591215567e-08,1.0431151626392854e-07 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018548105197563582,0.026410012249594838,0.4828054142252769,-0.07043439754746882,0.033338187152341645,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.028411747401612633,0.05196323533029206,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2102009260100256,0.03318450794994474,5.255565271490306e-10,0.14500515613661322,0.27539669588343796,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.02653206355345131,0.29309105026976245,1.5011533253255355e-07,1.4346064906321109e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1117901178736938,0.024736233890366843,7.726307962772605e-06,0.0631922054175609,0.1603880303298267,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.005770937583454076,0.16071812057849882,0.0004906514608679115,0.0046890065026941145 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20340258043419757,0.0291977152261124,1.0120641561591536e-11,0.14603944202086386,0.26076571884753125,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.008027300794031893,0.2771449617717523,8.926405857323734e-09,8.53069407693986e-08 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14827130048725798,0.026854086967977066,5.374393138116452e-08,0.0955125590659391,0.20103004190857687,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.0038700962344010675,0.19492479154134115,5.881193132514947e-06,5.620477068015203e-05 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09835662735555158,0.020235345710834605,1.5619173863568052e-06,0.05860136130603005,0.1381118934050731,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.011609049190285076,0.16687223542295496,0.0001239850021290032,0.0011848868852669117 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17653275674371574,0.028166025853374972,7.835192475388363e-10,0.1211965214572053,0.23186899203022618,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.004263458849175649,0.22055445070334928,1.884719935443419e-07,1.8011694120748909e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0634277649083222,0.018917466300236926,0.000859457892347245,0.02626166374573636,0.10059386607090806,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0002248905057476337,0.11770683716496634,0.032181022403077506,0.3075442250685532 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09007097266152368,0.020694468158791588,1.628665454284868e-05,0.04941369409743145,0.1307282512256159,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.00356254755873163,0.12408721485548263,0.0009368366939212523,0.008953062815687416 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.40032548200367085,0.04981290689904846,6.51479360072965e-15,0.30246081515928913,0.49819014884805257,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.041172032198420666,0.4569069895235121,2.8125129599780394e-11,2.687832934384927e-10 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04033412184456012,0.02552394033443901,0.11467279647220359,-0.009811353954473537,0.09047959764359377,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008944616935060245,0.07758395816553484,0.7133798263294295,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10450117815307448,0.020615322573194428,5.608108336805362e-07,0.0639993925495189,0.14500296375663008,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01597336700829967,0.15158600460537774,4.78679182554419e-05,0.0004574591086983892 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1155900033424464,0.02700662550509388,2.2339024261609795e-05,0.06253157788248831,0.1686484288024045,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01184058832981587,0.16498192064271516,0.0012553410573189218,0.011996911963647416 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06255238711159358,0.020976624194475817,0.0030011670982703397,0.021340772168652204,0.10376400205453495,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01751014690564301,0.13635593961151504,0.08726470485739911,0.8339621934646272 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10306926723368035,0.023248182326262433,1.1373102728640516e-05,0.05739484749527761,0.14874368697208307,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.0016191433420533067,0.14835442224995113,0.0006839370413632456,0.006536177898487877 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1483666392461669,0.02460365254602412,3.1526297827278816e-09,0.10002920203433516,0.19670407645799862,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.008628472081577064,0.17997777963697506,5.68763073074862e-07,5.435495378782297e-06 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003027552510631501,0.026014583532294494,0.9073981306977477,-0.054136967900560745,0.04808186287929775,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,0.01737428665855382,0.12081189476325044,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:5925,TP53,RB1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11083347076900228,0.019128774706196304,1.2062808625669979e-08,0.07325222365252658,0.148414717885478,428,90,518,8,log_other_mut_burden|lin_Bladder/Urinary Tract|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Skin|lin_Uterus,False,508,-0.023438134319167924,0.1594110341225143,1.7099031226887196e-06,1.634102311054331e-05 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09149862202709878,0.18991369871300767,0.63165109943732,-0.28813345239466215,0.47113069644885974,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04588315067456916,0.14149601543986504,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13817451774354003,0.16504197809148238,0.4056910873509071,-0.19173969557618012,0.4680887310632602,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08281781378715365,0.18706109838634935,0.9237532919369174,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057196368774888554,0.14759721623152153,0.699700978217477,-0.2378462624653397,0.35223900001511677,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03633732307251834,0.08788131021598179,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10647846165949924,0.18496865908811955,0.5669308040509662,-0.2632686194015089,0.47622554272050743,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008687282207159133,0.2875352647116979,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05446195349539348,0.1453479596268539,0.7091618488883549,-0.23608447785760492,0.34500838484839186,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03393222484249799,0.14992852166551054,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08708748266740227,0.13235724013499786,0.5129912441820503,-0.1774908704356056,0.3516658357704101,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03636333634392273,0.09069277091117003,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11654806271599971,0.17182500955735883,0.5001084798353415,-0.22692523730314862,0.46002136273514804,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06860483295398732,0.18678672431467308,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08479262102749413,0.1578514304898364,0.593074748149331,-0.2307478924446631,0.40033313449965136,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04150270980443933,0.12000725185582715,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03649958086768012,0.13164626645941904,0.7825066827369225,-0.22665755610848515,0.2996567178438454,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01626289475411384,0.04872110495301551,0.9718034799423088,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06535801427507294,0.175187721052025,0.7103657393136906,-0.2848372502419138,0.41555327879205967,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.052347918949252205,0.2034734522770872,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010518650873767502,0.13070502931814917,0.9361176954076472,-0.25075697986622536,0.2717942816137604,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06317727037854236,0.17592787945074553,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11525543647958175,0.16517579438847824,0.4879269694079883,-0.214926271806348,0.4454371447655115,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06329419593949849,0.21167926592486044,0.9404802865694325,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07697478949968241,0.16716166786886538,0.6467819883846384,-0.2571766233099732,0.411126202309338,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011501789242347453,0.17329157305298928,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03059822289307018,0.12669116400770392,0.8099505119136925,-0.2226538054181343,0.28385025120427465,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.020379643326189995,0.09493713439697224,0.9747331744048557,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07281150371991353,0.2124190425469928,0.7329287112157901,-0.35180811200702644,0.4974311194468535,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14725835779355229,0.002098484862113868,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07593500309832538,0.21538069752981553,0.7256127147571783,-0.35460487658255724,0.506474882779208,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10479714003672935,-0.15226860491290073,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006818969820881697,0.10581269481688733,0.9488242068081967,-0.2046975932586215,0.2183355329003849,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06953884540661666,-0.0034852056370334806,0.993730344541434,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044645234427023804,0.13906032652454725,0.749252687471603,-0.23333239744490739,0.322622866298955,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06899132145496113,0.21144715277603346,0.964192424193284,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04783333077162272,0.1212879602436371,0.6946551329801143,-0.19461784711448465,0.2902845086577301,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01765945755602184,0.12667938123435957,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009964966110619273,0.12605270383240766,0.9372443016731292,-0.24201079849540783,0.26194073071664636,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03589272810124787,0.15122537199108008,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07623698360720686,0.2108708048497802,0.7189294101418907,-0.3452877490614078,0.49776171627582155,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11353186263249569,0.12197969220835152,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1084961909288863,0.1333062728222304,0.41882481221530665,-0.15797925148463304,0.37497163334240563,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0009331258791751011,0.22460086115228936,0.9275566244234728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03998255643572135,0.07834254679715053,0.611614636936378,-0.1166219631836371,0.1965870760550798,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09611489595913951,-0.021461974963071867,0.9549530254352627,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13395616847102074,0.1559556113801318,0.39368360569119065,-0.1777946565993894,0.44570699354143084,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0536600402448876,0.21787333978769885,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02352702104668372,0.1214569194107544,0.8470387679021594,-0.2192619014020328,0.2663159434954002,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02892016272358628,0.09975363621405732,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09288005288308387,0.1440231328346394,0.5213732970345226,-0.19501808744727506,0.3807781932134428,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11192082294954528,0.2592261304058123,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028600821790168218,0.12147481243500921,0.8146381530409327,-0.21422386830438728,0.2714255118847237,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10469772119568004,0.02632519627262702,0.9770888048613304,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10064876981815019,0.13866562781280842,0.47066927318168894,-0.1765398705712053,0.37783741020750566,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21776064212187304,0.31508959794193564,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05464899379058771,0.13922433759499267,0.6960167937391498,-0.22365649153964204,0.33295447912081744,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05654327304708454,0.09828628142688145,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04234149679277459,0.09599286098738964,0.660682166548678,-0.14954549815956192,0.23422849174511107,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11548097552031845,0.19064110247437857,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006349913641325946,0.13007575603699037,0.9612220216861522,-0.2663676450158522,0.25366781773320035,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0390367262911659,0.07763158921262028,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1145432168070949,0.16384661861458685,0.48711137969641916,-0.21298150696569518,0.44206794057988497,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14569317519638367,0.1076636973240833,0.9402561783874069,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15679800149208384,0.13883791928338726,0.2630966362640389,-0.12073504463958656,0.43433104762375424,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07273970783241707,0.18530824798403836,0.8670850705749964,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010575369592179891,0.13439720621781717,0.9375346657293828,-0.2580808176060979,0.27923155679045775,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008683071439127025,0.06665388093187499,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11099811046741058,0.17628070148791306,0.5312262148920477,-0.2413819908095911,0.4633782117444123,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12207772695373936,0.10188609734522247,0.9462574637850627,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12673512979253113,0.07803541046963602,0.10943418341039132,-0.28272569264134184,0.02925543305627959,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3007448708563821,0.09277574534051622,0.6985162532376802,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03093961262809769,0.15250723804955602,0.8398985501977543,-0.3357972376305893,0.2739180123743939,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0010647021297218848,0.00320548597713611,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17522368367609684,0.08491149109818745,0.04324781240617783,-0.3449593358502068,-0.005488031501986845,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.47276398954806825,0.11884197818709111,0.4971708399879019,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04845342266867503,0.10343685094288645,0.6411164405260158,-0.15831389617778216,0.2552207415151322,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06739761220134707,0.029020400066418206,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02953421831705566,0.08844450317808644,0.7395597048709843,-0.14726382437410726,0.20633226100821858,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.015326859575081236,0.09551759199296918,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046329449619205564,0.09690395051990643,0.6342629345272621,-0.14737878735809923,0.24003768659651037,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0691269349992647,0.04867758900800954,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02571670605761751,0.10350717978739762,0.8046047793265227,-0.1811911981458434,0.2326246102610784,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.009980381033582906,0.07969403110309113,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00925520182843752,0.10778387483865486,0.9318479328173929,-0.20620169396952417,0.22471209762639924,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012206110987827763,0.02315243101650118,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010996767518901307,0.10940125980756672,0.9202576406681486,-0.20769323476399315,0.22968676980179575,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006657023916658735,0.0995862770171453,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019707884619250392,0.08053839514993583,0.8074954530631964,-0.14128607331305054,0.1807018425515513,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04399603594306499,0.0846442803425286,0.9744449538485335,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03516369106682012,0.13053719990787452,0.7885342333217584,-0.29610383559595344,0.2257764534623132,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0290689780177431,-0.0060714675213970415,0.9726336318937702,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008593383229694338,0.12049771742399631,0.9433760218109284,-0.23227812176841095,0.2494648882277996,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.046054762244615355,0.04781234932541188,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025517096387387934,0.10101847770397562,0.8014142226741688,-0.17641596323693073,0.22745015601170662,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027803958732854298,0.0034497347138454015,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015735806769725382,0.07457249504095946,0.8335687331556094,-0.1648041003107162,0.13333248677126544,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03049311573077441,-0.02763750255524334,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011525731664200595,0.1380770945543821,0.9337442468726291,-0.2644864475047338,0.28753791083313507,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.021728262529866923,0.07904282995111585,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0016549107794746713,0.06259849159137126,0.9789937628435765,-0.12347769092092993,0.12678751247987927,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.26484960229430016,-0.1636836835632361,0.9984157213799838,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025735819595793,0.11321530346064718,0.8209247855863082,-0.20057834731433122,0.2520499865059172,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2751052093750703,0.2368704938513591,0.9791887224619256,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19104127036762472,0.1970510877588834,0.3360621816793471,-0.2028582414628278,0.5849407821980772,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16521601669420916,0.15247042331194954,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03380819437489365,0.13737861721486908,0.8064215843850573,-0.3084241372368483,0.24080774848706102,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2490081523879538,0.2042183579686002,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06240906252964748,0.13925411489944764,0.6555951176048368,-0.21595594678404176,0.34077407184333675,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06000886662665863,0.1440274619323024,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035752061800216714,0.15273223325344762,0.8156915841361727,-0.2695553222063233,0.34105944580675673,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026914609770084412,0.2004137186176381,0.977649408210028,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11143451823911348,0.18518536497486443,0.5495375168398997,-0.25874575171707115,0.4816147881952981,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09044285811480782,0.061298284565918716,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07854155485628234,0.1553145921684517,0.6148651724038612,-0.38901100078067274,0.23192789106810807,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12402827734346342,0.22535354884592684,0.9558949742541814,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10434448508610548,0.13225794017423229,0.43314966516653564,-0.16003537022368947,0.36872434039590046,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07634060892149748,0.10710234531962967,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018693687338133275,0.1300205332171525,0.8861445313205227,-0.27860102986871343,0.2412136551924469,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03248279164209565,0.07884037016505503,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01599428363416271,0.09983034491685813,0.8732328422937181,-0.1835637323902546,0.21555229965858005,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019364859430288366,0.010155553064347749,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019026009232660755,0.1367415902155445,0.8897917421466432,-0.25431653480206284,0.2923685532673843,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11192482619852641,0.00829888401775856,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06553231111950567,0.12475682345245596,0.6012618375251753,-0.18385302551751562,0.314917647756527,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08587883403475186,0.07068114222919286,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006983195706981897,0.13655710476486013,0.9593803138957238,-0.27995695858048036,0.26599056716651653,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.004874691399172577,0.14145220392020094,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014113268842845948,0.16082828230492638,0.930355300062069,-0.30737788661810517,0.3356044243037971,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.018584859085720242,0.018872913281172465,0.9916960348989801,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12877373587253046,0.13356740690032812,0.3387360071519846,-0.13822370612523302,0.3957711778702939,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004166643563753691,0.1541776784241659,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05091896669623194,0.15003466220452208,0.7354693866105967,-0.24899604961833208,0.35083398301079594,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.043592700641488,0.0598884092480974,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07914065433431036,0.13548058669218346,0.5612405054611965,-0.1916811795743358,0.3499624882429565,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.15512920570969224,0.2104575086806191,0.9509691818071948,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02241416312832128,0.12862924170845735,0.8622335772007077,-0.23471202730448687,0.27954035356112944,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026150992229229446,0.05764054762301518,0.9846655352926511,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08412420239434268,0.12403545475964316,0.5001513165521299,-0.1638191387724662,0.33206754356115153,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.015857897986527092,0.09784002380266951,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012850578178126855,0.10482254222323721,0.9028254051147252,-0.196686698069153,0.2223878544254067,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07921541130756356,0.12457490924324534,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013253456485087106,0.10366259790144142,0.8986799979851422,-0.19396512410157837,0.22047203707175259,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.084177648385162,0.10999099869142388,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03588546400705237,0.12721412459235626,0.778816221521654,-0.21841194761740326,0.290182875631508,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0034901786433625087,0.05894331179906524,0.9700679690002965,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10522995713669549,0.19786780794805342,0.596751551060954,-0.2903021550892941,0.5007620693626851,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08663555830262502,0.2349604744856357,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031536226803426194,0.10012119764527472,0.7538341072737347,-0.16860319554074735,0.23167564914759972,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0027578305691481793,0.028754543688205642,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04680118108110886,0.13822277829631702,0.7360608297312112,-0.2295022157384483,0.32310457790066605,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04459434570083498,0.13995565417507233,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02981377583476107,0.12521569841416375,0.8125891941142971,-0.22048883878059383,0.280116390450116,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.018142966838125985,0.03132292739455487,0.9764147093858516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03399964673261579,0.10395186922885737,0.7447158656028089,-0.1737971789982486,0.24179647246348018,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.035817039753483576,0.12074721896639669,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00806997100141488,0.1125320902880744,0.9430614459141817,-0.21687847223667434,0.2330184142395041,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06020809748520213,0.026422783528539828,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013689829898279184,0.10305903866417171,0.8947541981363123,-0.21970191276080012,0.19232225296424174,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00634244471994182,0.02311227950011806,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09360946587317781,0.13718191265103533,0.49754366567212127,-0.18061327016840273,0.36783220191475835,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00929678963451541,0.1934036986465453,0.9438001947036577,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02730875753442854,0.0830539854484967,0.7434094079951951,-0.13871379375322104,0.19333130882207814,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09545069622942183,-0.0395813367913883,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009509563688456993,0.12080241335842883,0.9375088726846712,-0.23197101980393475,0.2509901471808487,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00032432850387109765,0.07275813254444499,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0018492316492028265,0.06117759813385683,0.9759828954763518,-0.124141507799297,0.12044304450089136,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04574714057559269,-0.019563830800842934,0.998018743752871,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09357958831878062,0.10616628365588282,0.3814821899598251,-0.11864378877861546,0.3058029654161767,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.036389381094186164,0.15603672157472276,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009927517118874369,0.09860206252856582,0.9201272626358505,-0.1871751973964729,0.20703023163422166,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11065622808339164,0.127359214410183,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01774081416698574,0.18796581727371525,0.9251091350019329,-0.35799750073907166,0.39347912907304317,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09608663419199716,-0.00998511911850972,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000581433597972632,0.10331965972051488,0.995527979586782,-0.20595162333291744,0.20711449052886272,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04154534404518989,0.16679079281314807,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03805046034522409,0.16092876388487828,0.8138684428249955,-0.28364155493203747,0.3597424756224856,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03230227890876076,0.16767682102527146,0.9767897942462676,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07132414804257042,0.1278352866522615,0.5788959830376181,-0.18421494884709755,0.3268632449322384,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.045446210242107175,0.021360651229988037,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09843677008213418,0.18100420282799057,0.5885040476049687,-0.26338547583435146,0.46025901599861985,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0913172459985694,0.1298033599161212,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008927784423009507,0.12058902953979768,0.9412210441317161,-0.24998181973976177,0.23212625089374275,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006402769086916728,0.05840279417094161,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07643295260980004,0.11700473358351662,0.5160125458738211,-0.1574561771817285,0.3103220824013286,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007942404106704756,0.1952510199460072,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01967345208122747,0.09623330110542694,0.8386832263753664,-0.1726941758186177,0.21204107998107266,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08989913317427607,0.12018069945781186,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01957485817107095,0.13000551380778178,0.8808041644597221,-0.24030246098797442,0.27945217733011635,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010861406610999862,0.1877293141471268,0.9867875051416815,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005930777285821793,0.07015962274368258,0.93290532974701,-0.1343163102246069,0.14617786479625047,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21315582067234512,0.16821136395431407,0.9919986667747693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040903271967087776,0.12080530926352533,0.7360638498114551,-0.2005831003571079,0.28238964429128344,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03538167589577699,0.10416559824224333,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01899782274876913,0.1393207695761492,0.8919782609710243,-0.2595004273651236,0.2974960728626619,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03240628101034207,0.14579838041058069,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02610681300194243,0.1255899062632701,0.8360090699670457,-0.22494383244522645,0.2771574584491113,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0167510606412801,0.13483337862834452,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01309199147796836,0.09098834387782453,0.8860567865256839,-0.194975099271778,0.1687911163158413,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07892420640377339,0.07534436030450686,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001540874132035895,0.08228732477893265,0.9851201901384119,-0.1629491443139254,0.16603089257799722,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06836396348987839,0.0698120510228961,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062424829337216235,0.09276248953346325,0.503477634161005,-0.24785440376371617,0.12300474508928369,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.029521549977803426,-0.04724211887421787,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014892027950981985,0.08578961547298339,0.9862061369670132,-0.17298020058283803,0.17000179499264162,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007735471900123061,0.008421889335747643,0.9990098172080826,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051250697787207825,0.15076731574424435,0.735056379587248,-0.2501288720851147,0.3526302676595303,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13957867868475518,-0.018521131943806533,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009342847323718595,0.09149002313973931,0.9189919740935428,-0.1922287976727822,0.173543103025345,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010331029916221465,0.048461087097804334,0.9901822239590808,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07930375849056279,0.12022307073462772,0.5119288185256288,-0.16101873559824717,0.3196262525793727,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05681442447223745,0.08045840442487358,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04028574585072606,0.08660182488302806,0.6434297933788911,-0.21340032711501167,0.13282883541355955,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0315724809239452,-0.024645021052756146,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02437055602674228,0.15690573064156588,0.8770738294074657,-0.2892795303850594,0.3380206424385439,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09258218865797718,0.014147660675855631,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025665740609346403,0.08496234527096407,0.7635992912643954,-0.14417156760766633,0.19550304882635913,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07410719299703496,-0.03180869621442722,0.9681057644104086,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0015754441349337574,0.06848537088796486,0.98172088246378,-0.13532486160357493,0.13847574987344247,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07383932925954904,-0.04325477403047737,0.9987056728178246,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028120901582840745,0.09654456362721354,0.77181418325253,-0.22111073439805737,0.16486893123237586,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03989600199764608,0.031259767605139085,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05031790208328699,0.1217422380084142,0.6808018666037288,-0.1930413641154314,0.2936771682820054,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01665999812886729,0.10495568363820588,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11244345047844462,0.17678989282874333,0.5270986871777599,-0.24095450978559685,0.4658414107424861,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.031639424756681765,0.23595697859916337,0.9448126253726593,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11806297392259132,0.13477327409656356,0.3844050497597715,-0.15134496225377167,0.3874709100989543,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0315701888039072,0.2254974751515618,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013382652923106928,0.07385542293156397,0.8568011241933307,-0.16101753974175712,0.13425223389554328,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02338863759126552,0.004653810639946933,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09005706864394065,0.11511610057744852,0.4370071022226062,-0.14005673756232861,0.3201708748502099,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019815339624401827,0.1640961160641495,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05923101041264739,0.1057622332402676,0.577470583197026,-0.15218468141248834,0.2706467022377831,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03197805032157495,0.1427468132974035,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07635731835741699,0.12874509010118854,0.5552788405356152,-0.18100044971275486,0.33371508642758885,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013928912473136892,0.16716266625493367,0.9497529489704187,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03597645741487046,0.11002264371033822,0.7447758206194247,-0.18395567359080725,0.2559085884205482,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05590563539651765,0.06564795320909214,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11323989672221556,0.12301861135212867,0.3608740220025174,-0.1326708034356887,0.3591505968801198,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028796221308248413,0.12916269544816686,0.9134053709502656,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03311097079806658,0.08226763118255484,0.688716082768619,-0.13133968070966756,0.1975616223058007,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022481579364450728,0.08849577470685699,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06523091079358424,0.17310065907120506,0.7075806769891553,-0.28079237626946024,0.4112541978566287,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.024089118697926733,0.19936965509168275,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07738080014304645,0.11773095596687211,0.5134412281768677,-0.15796002750784177,0.3127216277939347,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.13425015217304043,0.23996734661085967,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08204828217062117,0.14482815309560412,0.5730843919596718,-0.207459070732041,0.3715556350732833,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11838126635007153,0.10886420345443515,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06008539226402517,0.1316224351305043,0.6496270656405965,-0.20302410656442652,0.32319489109247684,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06013998917308348,0.15833752385928573,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03780866974259655,0.11055197692020512,0.7335081980847076,-0.18318158327262493,0.258798922757818,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.049074170742366786,0.18434509448089317,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022051023097208192,0.11842952287139118,0.8528994682177081,-0.21468621989855585,0.25878826609297223,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01180087434428867,0.09316083207940844,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049371056794161705,0.088679553739219,0.5797122946738096,-0.12789684527376793,0.22663895886209134,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10051322652806632,0.004645581803517929,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,5.1161586281195555e-05,0.0838083000289195,0.999514883671784,-0.16747924306251658,0.16758156623507894,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0785518116111342,-0.035172236535148914,0.999766777543677,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07184125302283402,0.10100868150153404,0.47960390088957217,-0.13007222427182885,0.27375473031749686,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03899982300107029,0.10205528439490529,0.9384017168502401,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023726285867654077,0.15281824083735168,0.8771221274767401,-0.28175302484935905,0.3292055965846672,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02517056625074004,0.2557467656431591,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04029001566044644,0.08307495751368972,0.6293969903918998,-0.1257744581881774,0.20635448950907026,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11359638350131962,-0.0787965438131165,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0005356792512591555,0.073742522065883,0.9942273941254153,-0.14794488045516468,0.14687352195264636,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04340559410385001,0.040801041496497485,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03915881495407806,0.11876268212970088,0.742720526157997,-0.19824440390968304,0.27656203381783917,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0541083965182269,0.15453947657239314,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010558925873296182,0.09055577855384164,0.9075528486198825,-0.17045949615861533,0.1915773479052077,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03319069291491688,0.03072400991755846,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022854004396787347,0.09763277121637548,0.8156931255448495,-0.21801913318735822,0.17231112439378354,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10914506015974446,0.12261036960081977,0.977649408210028,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03653593103328181,0.08319191501073493,0.6620605250531628,-0.1297623375206389,0.20283419958720253,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0095314896867061,0.0467812735934105,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01809824804069067,0.11593724287527482,0.8764583517386496,-0.21365699823036471,0.24985349431174603,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02900885093714904,0.07349325612492667,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055092050956649666,0.17347113822701438,0.751865921677625,-0.2916718133865122,0.4018559152998115,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.001977173943731422,0.20345462178424492,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040906834662493924,0.1399839152645844,0.7710900670727614,-0.23891702479422425,0.32073069411921207,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03222643568671117,0.09561707634383054,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0059905460427694835,0.11919312364598121,0.9600774376850822,-0.23227311315178464,0.24425420523732363,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020379009914985816,0.021675247842797778,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06707150142384458,0.17740335813032274,0.7066673890993043,-0.2875527585047424,0.4216957613524316,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08042441298752917,0.1694664543751398,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08856229064356448,0.12146891446722774,0.46868934969145637,-0.15425060958138748,0.3313751908685164,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.012281785251334729,0.17364405868189364,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06963656874184171,0.1458176792105223,0.634643328703549,-0.22184881867990258,0.361121956163586,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05867369980488363,0.07992134749527513,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010047972610883082,0.12005787707719688,0.9335703726048694,-0.22994430406192806,0.2500402492836942,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10806804894214973,0.1836143829551966,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20091911289611922,0.15562022028809797,0.20146705626284342,-0.11016127493424852,0.5119995007264869,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2762613266773137,0.08361985432363318,0.8177134279159035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11649728326683481,0.15543528324709366,0.4563960315851505,-0.19421342068612088,0.4272079872197905,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11185197906493521,0.0552389693011885,0.9353936944091839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019918168428555726,0.129741354406741,0.8784851415374846,-0.23943110361185257,0.279267440468964,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04868087625552829,0.18100042866158048,0.986191362849829,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03877264411711519,0.1342830707315381,0.7737449703859591,-0.22965538949500802,0.30720067772923837,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.023353624157600675,0.15729330080359533,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11003348101006438,0.12919780562576844,0.3976767322035254,-0.14822925249906155,0.3682962145191903,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11755009902533098,0.08984345237605074,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05524735455278294,0.2660311128443388,0.8361653089068853,-0.4765412626677429,0.5870359717733088,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7473462713246929,0.5288319202041329,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020602452638574416,0.09744609669672151,0.8332497927667956,-0.1741895191042523,0.2153944243814011,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09483671253333747,0.19205837688807065,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008004052528259607,0.0905570651064736,0.929854102197085,-0.17301694128571835,0.18902504634223757,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09802159009403352,0.15068551176954972,0.9916960348989801,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07833217071012674,0.12939132226482639,0.5471298043694266,-0.18031739704854802,0.33698173846880153,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12337958777354958,0.02078691746773777,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0009691002935928012,0.0911258390253438,0.9915490055439553,-0.18312705697102374,0.18118885638383816,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02999984100140603,0.12169851455754345,0.9992761255456871,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10854219528498871,0.1324178603060726,0.4155303120661227,-0.15615733581335528,0.3732417263833327,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.169729581692687,0.03054421882514211,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07515287135202448,0.13593642799900377,0.5823519471134966,-0.19658017634524272,0.34688591904929167,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12654732381539216,0.02452528634361268,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012057451975532998,0.11028039427029768,0.9132902916456342,-0.23250481900906905,0.20838991505800308,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017799622188880513,0.09266806629458499,0.9895309118568834,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039617250767677865,0.08383272619067549,0.63817575307758,-0.12796198108274057,0.20719648261809628,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05935316051851956,-0.02853422923557025,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0694004069336451,0.1307045132171584,0.5973353668113363,-0.1918741921351673,0.33067500600245747,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.029745248558531858,0.16075984956683848,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010308976912760144,0.13728665178054114,0.9403841621564651,-0.26412312966542134,0.2847410834909417,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06908299079544566,-0.010035768736842508,0.992787535469879,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12539726886322164,0.17844304066051533,0.4848543256955766,-0.23130528682997756,0.48209982455642086,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02469629376379764,0.2626121406726932,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11735801621483181,0.14005589456774353,0.4052848297086863,-0.1626097278187174,0.39732576024838107,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08276146756971345,0.12346770879474094,0.9237532919369174,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09012666052083346,0.10799072873407914,0.40715977077366383,-0.1257437303222688,0.30599705136393573,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0763451727265822,0.06471930766899596,0.9239663408808872,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049284136797271866,0.1351255028565789,0.7165551405036599,-0.22082789463784178,0.3193961682323855,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0014639688028437847,0.2199826213315569,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009092383323136902,0.09845131410856373,0.9267144705136323,-0.20589375604066218,0.1877089893943884,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.061792453965928654,0.090522146612629,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06331589871156819,0.18349263534036428,0.7312174467155823,-0.30348065291921233,0.4301124503423487,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.21923403863720978,-0.027138287346203042,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07218929686549372,0.201633920650222,0.7215432164928245,-0.33087116738206845,0.47524976111305595,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11464516830631642,0.08547816541414381,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017213710853712552,0.08020732411181992,0.8307716793788308,-0.14311844550328,0.1775458672107051,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03077624123777194,0.010675330127246163,0.9817873441877563,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01693348364561809,0.10815825666771324,0.8760986734131919,-0.1992717907651262,0.23313875805636236,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10089883954807104,0.05839766336209949,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003147259557211798,0.083585588159654,0.9700852179548454,-0.16393795040841896,0.17023246952284254,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09452413517692687,-0.07385409703449518,0.9969763314031036,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022478259174704827,0.1392560762720423,0.8722900538272721,-0.3008471892163451,0.2558906708669355,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12914662530791896,0.032439291246830836,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019207719245072773,0.12245035774899461,0.8758638731610515,-0.26398249663586043,0.2255670581457149,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.20087967361859468,-0.16674381309604078,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031506046534106574,0.10078984448827569,0.755640050263306,-0.1699699818041802,0.23298207487239334,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0683464686261188,0.07223014773582702,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02099956207277963,0.07192706001808533,0.7712946946545787,-0.12278058220732326,0.16477970635288253,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05613840181637639,-0.03569486281409635,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03505996234124107,0.09611182876064042,0.7165147316008668,-0.15706484580126864,0.22718477048375077,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04467802092946637,0.03509729781875718,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010065622349446857,0.10793572553495168,0.9260011220167704,-0.20569481866525388,0.2258260633641476,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.024543087877766295,-0.01950075677064945,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012401846908170977,0.09615948783628472,0.8977975645493204,-0.17981823036907982,0.20462192418542177,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01238325492883481,0.03147309759192798,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007222253201863761,0.11028557989270453,0.947997094800027,-0.2132354797431617,0.22767998614688922,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.054313858072159354,0.018443464769500956,0.993730344541434,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05353546476408322,0.06588141714501701,0.41955481421168117,-0.18523054113876672,0.07815961161060028,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11916313375124726,0.022769950042664727,0.9275566244234728,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0137328074441626,0.0666279621121254,0.8373789291712188,-0.1194545910559552,0.1469202059442804,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1673733184365984,-0.14325504453999255,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028368102856046337,0.10928177354009896,0.7960425856789298,-0.19008304978150342,0.24681925549359612,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05283677840725035,0.030499610805491566,0.973649621744121,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02913270143079673,0.1178192602534808,0.8055193294804492,-0.20638464397385425,0.2646500468354477,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.005002427851930504,-0.008469985016574687,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0376758995291136,0.10446757643127927,0.719589345964943,-0.17115181021052114,0.24650360926874834,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.002996596940553022,0.05299969669242592,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022811581241494818,0.13302827911340534,0.864405449664318,-0.28873132214915836,0.24310815966616875,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017212043534050463,-0.04571458626254984,0.9854445582989166,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018714152033315175,0.12442608681012092,0.8809343200753064,-0.23001005147603912,0.2674383555426695,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0029227054719701117,0.041942253967433354,0.9867875051416815,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02267267382626861,0.09255485097899524,0.807292722047102,-0.207687184696549,0.16234183704401178,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06859423139934807,-0.0445134726421254,0.9744449538485335,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003967704298114955,0.09869311914679757,0.9680609118499349,-0.19331702980351495,0.20125243839974488,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3495906486514083,0.32031722357695536,0.9966883940680653,1.0 +ENTREZ:324,ENTREZ:10664,APC,CTCF,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037421594581577004,0.1090767457022464,0.7327019768375761,-0.25546290241106057,0.18061971324790654,59,7,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13621518562507182,-0.16116811678858228,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11779408039242971,0.11908704120356525,0.3264379760347913,-0.355845683806137,0.12025752302127758,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06064700903853282,0.009792909261111126,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21456806231268333,0.18369798832517195,0.2472594911297008,-0.5817751087110321,0.1526389840856655,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05773208473172108,-0.01881637347239269,0.8552269457897888,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05005231858565605,0.0846423615233975,0.5564433225165428,-0.21924998840536963,0.11914535123405755,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027989630429483266,0.025107489333714376,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1540258583566199,0.2240517170662665,0.4943586895055392,-0.6018988591145079,0.2938471424012682,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011438805409754439,0.1356448130290383,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052326507122663304,0.13189102084057827,0.6929211910770616,-0.31597290113543497,0.2113198868901084,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04285411604615339,0.08004232576612536,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033451456091756836,0.08796415214543467,0.7050335283607164,-0.14238637856695763,0.2092892907504713,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.030733473389038386,0.05557015923817543,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04767123503268193,0.20780420330159158,0.8193095884853241,-0.4630659185523771,0.3677234484870132,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05463516869336927,0.08965534125326914,0.9784383200536336,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009295958236529647,0.07960286076910453,0.9074124903841819,-0.16841980958834335,0.14982789311528405,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04892789142270006,0.05883952601511789,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08514887447238015,0.08783954522337913,0.3361279218970624,-0.2607376234430804,0.09043987449832008,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0074017181897393335,-0.02905999407287475,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10210116320731931,0.18945115869195642,0.591864225893427,-0.4808086333015108,0.27660630688687216,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03860131358158987,0.10864429380485384,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06928150772682036,0.06996868997511402,0.3259354892898195,-0.20914692607121216,0.07058391061757145,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06942916832601782,0.13220066815469153,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15102105602635374,0.2279086238473602,0.5100179617823544,-0.6066039035835009,0.3045617915307935,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04304119418351973,0.054978158675799395,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.134131513702105,0.09306343938302589,0.15453429437448896,-0.32016267830593614,0.05189965090172613,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02687664451154933,0.04650798432941084,0.7729635971926234,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07574744057113604,0.08639678728022743,0.3840128650886435,-0.24845215750750238,0.09695727636523029,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012301458878632513,0.03337475287525781,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027731407209205222,0.2082230423879135,0.8944813621682286,-0.3885005237142677,0.4439633381326782,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14326162209834767,-0.012976064980654576,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18159078640804213,0.2044813620101781,0.37794324434813586,-0.22716163201449505,0.5903432048305793,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1115280525803147,-0.0928713902897424,0.9171668992289758,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05736687665194358,0.08618477298729474,0.5081186887951803,-0.22964778305553352,0.11491402975164634,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06481588735853765,-0.0397058461562266,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1355564915789983,0.11002438222611872,0.22257938555012488,-0.3554920978282031,0.08437911467020656,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0823037795895505,0.10206520998365191,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06589257215213112,0.0949666833591255,0.49036824539639545,-0.25572826725415077,0.12394312294988849,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.026593304322280974,0.05551090085149118,0.9418332435783486,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08224214255390949,0.09656490065815565,0.39767089534893907,-0.2752726285147204,0.11078834340690141,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04302667343030278,0.09910802601550302,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05062881356667986,0.16489124684218,0.7598390595058523,-0.38024171941231777,0.27898409227895804,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10235767774042483,0.049489769094450554,0.9673781001375229,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15313377251543575,0.15268162648176994,0.3197779402837819,-0.4583399950268231,0.1520724499959516,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.018200150628176818,0.07085709391734761,0.9027017389660956,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010554853003374708,0.0759049113322627,0.8898584706675571,-0.16228660875951198,0.14117690275276254,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09136441452628709,-0.05652463579225148,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.20421236389543418,0.20099447586736152,0.3135732359404044,-0.6059945962353426,0.19756986844447427,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.029231846862935583,0.01884696930694309,0.901410374901842,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09655088140229,0.11262707322830848,0.39460185386043833,-0.32168919283251124,0.12858743002793122,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.019443411361025547,0.02643175574472391,0.920957044807631,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11920654604423912,0.0720204644875238,0.10294265441628428,-0.26317340319831317,0.024760311109834912,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12756841465459245,0.12730109793138514,0.6839484127328216,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08678414350130416,0.09441161194686042,0.36154797014405593,-0.2755102666602864,0.10194197965767805,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0961613200066192,-0.0372016627065969,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0541232573875903,0.07944336937823322,0.4982305666407809,-0.21292828999184021,0.10468177521665961,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.22957974227932573,0.21312008900408586,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10070829722079476,0.08655298316496898,0.24906683040445904,-0.2737252452818373,0.07230865084024778,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04503908992353035,0.009049375937000533,0.8577407808028615,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07344329003619425,0.09195087565816455,0.42750009082741836,-0.257250471443143,0.11036389137075452,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12452533028805014,0.11272424262273861,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045765991951717815,0.07026146228635215,0.5172168149187852,-0.1862166538072507,0.09468466990381505,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03577899762987237,0.06449902185031607,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040714738117195975,0.17109731126870908,0.8126948834608618,-0.3827333899843396,0.3013039137499476,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13220958444212524,0.015053935201576612,0.9764147093858516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13419418675941566,0.1979890046929207,0.5004290182216957,-0.529968567826352,0.2615801943075208,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05086555436932115,0.009574705989155033,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.073264577684992,0.08414471138970317,0.3872782819483237,-0.24146745906200276,0.09493830369201875,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.002306494393647708,0.015444269205582109,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14981047726146324,0.1799985928404813,0.4084414154506031,-0.5096225374556735,0.21000158293274712,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10336487083551908,-0.04791515978715344,0.9252876586321025,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1545813479892628,0.08849093498449839,0.08561361129221692,-0.3314722065389276,0.022309510560402035,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.30058124404864484,0.05975049249857763,0.6528607274170573,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1707903918249055,0.09862054430875877,0.08828350058539147,-0.3679300508924426,0.026349267242631563,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008073936715530455,-0.08746920445757762,0.659371665428829,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13140693336172118,0.10823711806212584,0.22932709619266106,-0.34776984945368977,0.0849559827302474,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.4667562928099019,0.11993194367525835,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02988511476854784,0.06417110883846858,0.6430551183327203,-0.15816133355309542,0.09839110401599975,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.061066690043116156,-0.018219152804596777,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058793002671074825,0.06993826966727394,0.40377924957329814,-0.19859761168655493,0.0810116063444053,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.022113395693578265,0.041017352877646886,0.9235345118679857,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03862527792363087,0.07472832152916699,0.6070816846688993,-0.1880050641761479,0.11075450832888614,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06164209129135844,-0.00653676073650741,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08164285141149957,0.08708196481968976,0.3521186057894614,-0.2557172187333621,0.09243151591036297,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0025380447670345285,0.02021640379371971,0.9090812501778921,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05488951358781319,0.06322979114931249,0.38868971101412964,-0.18128406512325806,0.07150503794763169,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007307195941294516,-0.0199436291147765,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0380175530913316,0.08609239110430203,0.6603221368787565,-0.21011379074212916,0.13407868455946598,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0025963548047680234,0.07668680272053886,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009664873765468996,0.05961577957732178,0.8717390350522204,-0.12883511910627543,0.10950537157533743,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04666294494526643,0.0647498977204249,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03655178760844159,0.07051104209301746,0.6060356298795734,-0.1775013523887251,0.10439777717184194,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028688503027941785,-0.006043299003352473,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09120447071057988,0.09272230376699704,0.32912031118193275,-0.27655371493452374,0.09414477351336395,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.038354575161367095,-0.013545002912066251,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0572800136645405,0.05987956156204211,0.34249095698998555,-0.1769775516795094,0.06241752435042841,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022070423834635738,-0.04867666536055693,0.9045618832985359,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05236146870866212,0.0723993065863933,0.47225733490567645,-0.19708562042782943,0.09236268301050518,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03223890717744838,-0.05478385340298595,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08123882757891783,0.08145053690444141,0.32244690680918764,-0.2440561308979723,0.08157847574013662,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.014681170433910618,0.02536709107171653,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03647789384710476,0.05165855833762731,0.4827495705894068,-0.0667860928808194,0.1397418805750289,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2669156394373403,-0.12616232567765762,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01921763833656811,0.09305466315817108,0.8370615498160903,-0.20523125951688742,0.1667959828437512,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.27870129744584815,0.19453716055629555,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04651564892316869,0.20832120133786203,0.8240453353285695,-0.46294379679173064,0.3699124989453933,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14603462604152384,0.013604256786123184,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16399882785430978,0.09274576970475545,0.08193665003695465,-0.3493949798194531,0.021397324110833588,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2571943875885956,0.11489104022562313,0.6430699474171485,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09894443952062677,0.1291676985496506,0.4465737989225317,-0.35714698984213195,0.15925811080087843,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07183374496683413,0.03978177774815465,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15698511659765851,0.12454386434466296,0.2122193230100941,-0.40594475404390873,0.0919745208485917,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012118481696270552,0.0903404926107866,0.8278117867587848,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06179380519334369,0.1455864429092452,0.6727087274603611,-0.35281695783513095,0.22922934744844356,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07782385865893088,-0.03960151954606293,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16510294285176447,0.15196779111258013,0.28149307269261176,-0.46888222879229036,0.13867634308876142,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1308791342453381,0.17373252507759063,0.8768618853741261,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1358714050581814,0.13379921764605496,0.31382014079118453,-0.4033322301339951,0.1315894200176323,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05897852683020398,-0.03594464988645077,0.901410374901842,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09975870330889046,0.09284440347431765,0.2867751197002408,-0.2853520213700063,0.08583461475222538,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026071157601300975,0.03327789005830006,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010994580148017468,0.06904846211672981,0.8740053159799082,-0.1270313289182837,0.14902048921431862,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019838126335815023,0.003887999614757713,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07258852816096054,0.1293043572534732,0.5765639487928725,-0.3310642553389618,0.18588719901704073,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10501060074982226,-0.04080608543323524,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08810403277311858,0.11025859669399886,0.4273020298597635,-0.30850782707249297,0.13229976152625578,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07433871822934321,-0.01862668644756953,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1929927281334187,0.13008905474217355,0.14299619525042595,-0.4530370432408196,0.0670515869739822,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01880574970174036,0.02490453964802787,0.7607934302264618,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006867331021730341,0.11564241575913982,0.9528371033737617,-0.23803322628518275,0.22429856424172206,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01636935354940123,0.0029608199791310943,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08083345473200852,0.08981931421785226,0.37162583306475094,-0.26037970553296635,0.09871279606894932,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011702076525120517,0.021881197866743776,0.915561182973695,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03959498546774241,0.14717988783241145,0.7888041231969318,-0.33380338912490043,0.2546134181894156,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03558443282611294,-0.0029474172573889464,0.9726336318937702,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04532247346546118,0.08324825482919117,0.588101498610778,-0.21173336371175072,0.12108841678082838,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.16424990347908125,0.12847191481521658,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056283787344949536,0.08292763233675084,0.49984750671558353,-0.2220537623611306,0.10948618767123153,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0197556962723105,0.007652844695866537,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01691992188836813,0.06368487334554412,0.7913656212655777,-0.14422416977198904,0.11038432599525277,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023741919778395824,0.032663493520005894,0.9732342286065081,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07472365079231574,0.052666150014204674,0.1609599285066762,-0.18000178458251795,0.030554482997886462,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08562460252098772,0.06804291343161738,0.7815068115919459,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0717052707332874,0.0712966915668157,0.31845426273752303,-0.2142253264340659,0.07081478496749107,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09010325917044583,0.05503711588962948,0.9027017389660956,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06207406264083213,0.06903504545904804,0.3720425040739582,-0.20007315219057364,0.0759250269089094,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0035163007116496866,-0.0007159000106520541,0.91574265170323,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19707754954125511,0.1924153318974239,0.30970639813148465,-0.5817103174447296,0.1875552183622194,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06443684543191126,0.06657268457654156,0.897405574514287,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022963822053055354,0.07768943123818152,0.7685348070632518,-0.1323351381665927,0.17826278227270342,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0012362156560315847,0.01879045693326532,0.9691554932400821,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13639567296815616,0.14897948799820626,0.363459003552576,-0.43420142609878654,0.16141008016247424,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.030881026528582767,0.03358079576520137,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006366639227022556,0.0748467634897646,0.9324859334608139,-0.15598318758519578,0.14324990913115068,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.015036510295222377,0.008502677670965563,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06957373843351829,0.06475092396166698,0.28677038630996055,-0.19900899113448467,0.05986151426744811,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.044056639784671094,0.05250624852334038,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00830347008300298,0.07894097858588678,0.9165679407379784,-0.16610423780293251,0.14949729763692657,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.058465728670314764,0.023437575548623135,0.989733344444655,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05872096309662252,0.07148143194245721,0.41451753989863993,-0.2016103095463544,0.08416838335310937,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.00967854716676297,-0.0074537725047307615,0.9266313996019341,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05439644171604384,0.08048473194028216,0.501642591454112,-0.2152831284207345,0.10649024498864683,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020923968602057783,0.10781639380645992,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03342769689313529,0.047181191924954846,0.48129256709946877,-0.12774155569080528,0.0608861619045347,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09149718288923324,-0.06980491028693536,0.9396519533333579,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006780993226990182,0.07911982430838496,0.931976812234715,-0.16493926845213686,0.15137728199815648,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.002001434507253238,0.06168091260792099,0.9918526261485133,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039351982509248436,0.06424141558271644,0.5424049509210516,-0.16776874247300283,0.08906477745450597,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04336416534138956,-0.03902969818041596,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021312383820479588,0.08322470034271397,0.7987349519211195,-0.18767618931920288,0.1450514216782437,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026435521881119976,0.08856914655554565,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014236542508926149,0.10598599219360282,0.8935808770827507,-0.1976264370906079,0.22609952210846018,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11158459392207978,0.12085938707776667,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06944048554148771,0.15635352567358538,0.658498634695531,-0.381986729950732,0.24310575886775657,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08869116082369355,-0.06958960028929818,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10204440903978386,0.11779984657720013,0.38969167536397886,-0.3375229470585089,0.13343412897894114,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05017502651803907,0.10136820954598265,0.9196137660184385,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08649954929763502,0.11275356913886336,0.4459005223372493,-0.31189072245007665,0.13889162385480663,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04231735450566694,0.09008848874229473,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00023324135738833282,0.11812382840605812,0.9984308780077663,-0.23635940982403683,0.23589292710926016,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03993279701575794,-0.022639004121488383,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10149759175121495,0.13174467249292235,0.443981731056462,-0.3648514395854575,0.16185625608302764,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07576073060081973,0.011091640257739394,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03093054569702675,0.09403481512809479,0.7433197260388857,-0.2189034627475877,0.15704237135353422,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0043591877130328095,0.048767907641745434,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15067975363787045,0.09412686900328757,0.11450138858861479,-0.33883668376297427,0.03747717648723339,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008738436336420767,0.062308186190204,0.7128721746011171,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13568545102584106,0.07288579611893008,0.06739872422130876,-0.28138208146388427,0.010011179412202142,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10098526105973869,0.014366348317108299,0.5990506592577463,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16486811153390124,0.1252741821836197,0.1929997154380639,-0.4152876335386073,0.08555141047080483,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02440893370759195,0.08173202777056034,0.8140390093255331,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028742281730394947,0.0825488163340168,0.7288805241527444,-0.13627045088612436,0.19375501434691425,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.21210986562953707,0.17118017159605636,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024246033729939706,0.07699040942796326,0.7538777380439433,-0.17814766926117637,0.12965560180129693,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04046435822819438,0.06480276197581393,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10652043522989907,0.10556930369242286,0.31689179817390845,-0.31755046638409906,0.10450959592430092,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04207958295207789,0.06796404422659548,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12821835985861912,0.11507499379485546,0.26948744075579484,-0.358249994777328,0.10181327506008972,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028263816654491108,0.03938620482741181,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01449971291810322,0.07325442586071565,0.8437424287724885,-0.1319337978741007,0.16093322371030716,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07733280309842863,0.09066175234141,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06359790335486995,0.05491206610133953,0.2512336821858476,-0.1733655594329018,0.0461697527231619,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07295311527351002,0.02416188110874941,0.8585176148211594,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02882116697455,0.06562776598075844,0.6620715404256959,-0.10236686794751823,0.16000920189661824,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.034994100504257566,0.00452995824092108,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009466353656663939,0.051631856109763126,0.8551269512199242,-0.09374425607831838,0.11267696339164626,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007973763073357877,0.013497694607407596,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07007655667122607,0.12019526460161387,0.5619927898013442,-0.17019035374969033,0.3103434670921425,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1399073821966028,0.004942160964827659,0.9512976205783472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0038743365251771395,0.06408336802225235,0.9519855234900739,-0.13197516391722722,0.12422649086687294,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.010674611876276498,0.05138027702751783,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0016059370617430672,0.10463181229146862,0.9878034669510162,-0.2107619496079718,0.20755007548448567,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05075239665027475,0.04271693102143178,0.9990191441902606,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05153539062791111,0.06778449677423747,0.44996713264402455,-0.08396388772023052,0.18703466897605275,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.025468159501048544,0.027028609513426893,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056434684032070026,0.1191214788366868,0.6373369750339041,-0.1816857592293613,0.29455512729350136,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09397753311978665,0.04588941351625586,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0028170335420236877,0.06457684736500718,0.9653451370469728,-0.12627024500043765,0.13190431208448505,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07220682556844972,-0.04376262103651183,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04622883068179788,0.05583052645176341,0.4108347995604893,-0.15783246283985156,0.0653748014762558,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07094435303684242,-0.06710711038603161,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006615424342095407,0.05824749067492682,0.9099421460697688,-0.10981965045575064,0.12305049913994144,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03801801627199407,0.04860025246290805,0.9890962952045544,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07585993865602793,0.07206603480019974,0.29658912539225374,-0.21991788956716346,0.06819801225510759,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006876093083611937,0.027385913480164503,0.8839993607754738,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006683123661101191,0.16088703321854572,0.9669995008513685,-0.3282917205249771,0.31492547320277475,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04288175749432713,0.15758657686312336,0.9962315319978402,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2619488626015367,0.11943124147676644,0.03204484848673418,-0.5006885125575283,-0.023209212645545124,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.058303010579078246,-0.00950952820887294,0.4282445913712306,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029136576042823017,0.05383195672240703,0.5902745086997161,-0.13674512423708818,0.07847197215144215,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02484150738954753,-0.012997358501426295,0.9531324349182967,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09035774581033848,0.11920815058007725,0.4513327498976276,-0.3286514434181389,0.14793595179746197,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.033547458750776256,0.050821720873696415,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0708900475774352,0.08128320993874118,0.3864989323171626,-0.23337286905802324,0.09159277390315285,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04182506428097234,0.06273813419940098,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0971533460433389,0.09108686508017907,0.29028784960054504,-0.2792333949144791,0.08492670282780133,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00060232358697082,0.06407870718128474,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0827702802609627,0.08461890097253487,0.3317997601537298,-0.25192105310772794,0.08638049258580258,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04699273341896308,-0.0032221351321852034,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10850551839521652,0.0989280411455415,0.2769651890650821,-0.3062598548810601,0.08924881809062707,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012128664504110048,-0.011186386467147591,0.8725380346331878,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02890236157705045,0.08434992898989763,0.7330220251487451,-0.19751546709164386,0.13971074393754296,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.017095637219783858,0.05313257893873966,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.23943291061598718,0.181577979967122,0.1921454266206974,-0.6024021206907214,0.12353629945874708,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04584439264039542,0.011030338399288594,0.813283143145888,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10502812894837404,0.10261994920975619,0.3100639547530179,-0.31016248449808864,0.10010622660134055,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1485217804704754,0.11487059604281337,0.897405574514287,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18756052696841116,0.16872550816666415,0.27058889948045856,-0.5248380119905555,0.14971695805373317,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09936370078528724,-0.04343720722599001,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01181301242013329,0.1042974473867727,0.910188225197655,-0.2203006390455793,0.1966746142053127,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.066851608689787,0.10758758447328416,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13306128176792692,0.12515347781761654,0.2918216785337115,-0.38323951918301113,0.1171169556471573,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0613415055575294,0.08421690028568812,0.8799526010712531,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07418747090634732,0.09412652849558373,0.4336019350852496,-0.26234372036624987,0.11396877855355524,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.019031679594476263,0.034412772533385864,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021612336875358417,0.08506776214960539,0.8002897048518167,-0.1916603704301897,0.1484356966794729,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0949894842176305,-0.03306537324557634,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011307996772046029,0.043710224651019064,0.7967208141238107,-0.09868349085256338,0.07606749730847133,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0769634974160359,-0.04382544930680083,0.9738068609884574,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060345532573775354,0.06383859492028932,0.34818393370615697,-0.18795706550686542,0.06726600035931472,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0287597854083996,0.0231640930341942,0.9086350165348037,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12676826127095905,0.16931049697184425,0.456849643569317,-0.46521512225244177,0.2116785997105237,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03736138975033368,0.17226789721262584,0.9353936944091839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04018781147812887,0.07448900999628583,0.5914651193511513,-0.10871359783646112,0.18908922079271884,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11294545702765683,-0.07950583526837716,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029203517551344746,0.049664549524083015,0.5586578314100665,-0.12848153745628033,0.07007450235359083,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04570871334638391,0.01733575696993306,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014940545678600536,0.11924180101923167,0.9006944484842638,-0.2533015095558063,0.22342041819860525,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05946473955766883,0.11771455952033494,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04782554671722569,0.06799754457474809,0.48447541608689604,-0.18375070155035467,0.08809960811590328,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.028566924023608848,-0.004861228523442583,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06763318333297472,0.06328436270062772,0.2893398373239133,-0.19413682184513906,0.058870455179189624,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11285111583251055,0.08779403111333807,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03119670895665311,0.0518235502395262,0.5493830219551079,-0.13479050979701432,0.07239709188370809,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004448728649601252,0.005339123769048107,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02876457301998437,0.06085372517938033,0.6380985200498067,-0.15040943635894258,0.09288029031897382,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03320574551514781,0.03893837787623535,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1889070321995047,0.13447064647109394,0.16506538183513986,-0.4577100243722865,0.07989595997327711,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020031140778084502,0.056494528080799696,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08257883567246918,0.12214090978376495,0.5014947658816791,-0.32673503539475884,0.16157736404982048,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02238082134361853,0.018468184917994453,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04678049259150493,0.044845797432586425,0.3009333745829616,-0.1364259643178938,0.042864979134883956,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023733625776312627,-0.011654871115834978,0.8886938718153086,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21168662968391663,0.16660515131684228,0.20862212796051804,-0.5447255817573204,0.1213523223894872,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06016204516471764,0.008491254040802698,0.82185729615414,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04078385665313002,0.0858049700055384,0.6362371851485461,-0.21230554771410468,0.13073783440784462,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.022957138136197198,0.09378424207169546,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03526272833948941,0.11854120594056149,0.7671003971313283,-0.27222322260945975,0.20169776593048094,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.050533730830838244,0.021620832304847806,0.9686101294099047,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08603713831700188,0.11328060024419168,0.4504289619501136,-0.31248183163758547,0.14040755500358168,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11606840161320227,0.11620191191351241,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12055402470223407,0.12879539797011713,0.35289871166074294,-0.37801235676947686,0.1369043073650087,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2525899369873748,-0.09311384574226417,0.9092831415853414,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15364916059234507,0.17113010743867124,0.37273902755690913,-0.4957333710691108,0.18843504988442067,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09213623084089861,-0.11407002154482372,0.91574265170323,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1307632710516499,0.12174199183915696,0.2869397142257072,-0.37412204516503467,0.11259550306173488,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06072198976033141,0.08264255234789135,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1245726219281003,0.13585156369197735,0.3627084477432231,-0.3961360282928089,0.1469907844366083,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.010441727749500782,0.05828215754946242,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011510884590262869,0.09970711367701812,0.9084639474232209,-0.1878007956957056,0.21082256487623133,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10843954731570647,0.03330352718003589,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18755830724829525,0.2514337558185179,0.45851352535551826,-0.31505060905364757,0.6901672235502381,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7406494660728281,0.5593809142026869,0.9366135780422296,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08245080130863104,0.07351869749059048,0.2664024161740249,-0.22941258356171473,0.06451098094445266,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10352479050793097,0.12138120786792465,0.8699728633396779,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06596646855325612,0.08757448117804767,0.45414384174617217,-0.24102536204714914,0.10909242494063688,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10453007281338828,0.09437800485525498,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013041384997834412,0.10592033173152994,0.9024067972907215,-0.22477311120388954,0.1986903412082207,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1154302898003767,-0.03467831139044332,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06837145530945568,0.06199981503377779,0.27438982206271234,-0.19230731962331535,0.055564409004403986,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.035735022959432206,0.07962980723663794,0.8709804306040525,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037455094490614946,0.1068732533408507,0.727179363103563,-0.25109168385166786,0.176181494870438,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.15784605102897478,-0.05491212105900852,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028861686738844698,0.114705508804849,0.8021704099137265,-0.2581547316865593,0.20043135820886987,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11755622320211559,-0.040206951429319064,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09427301583000937,0.07057826870173611,0.18652258137586414,-0.23535696468630823,0.046810933026289483,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023632996627549776,0.04681239592550973,0.8085168201280608,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013876817277451742,0.059682749200887175,0.8169079855845334,-0.13318093298827183,0.10542729843336836,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05556771461916941,-0.06125219968191342,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11546964181831659,0.08716448786144218,0.19012197420894142,-0.2897089703501412,0.05876968671350799,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0431604718853342,0.04844338313353284,0.8114284597256536,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003793809183805815,0.11809059554265199,0.974474561250541,-0.239853546103076,0.23226592773546437,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0674342572179907,-0.016681900834958286,0.998018743752871,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13809478409729878,0.19273319404924885,0.4763684064331263,-0.5233629493886143,0.24717338119401674,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0040136250469517895,0.10367019257698316,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07242698815954289,0.11871315371072153,0.5440248469198228,-0.30973120112448055,0.1648772248053948,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06842097226576468,0.014434285149328901,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11010498841792907,0.1281874688068466,0.3936839174056668,-0.36634808740342006,0.14613811056756196,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06117086510090709,-0.06351302185515893,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1514894286052168,0.13667753599689564,0.27198274841020115,-0.4247039300813155,0.12172507287088191,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.013244245223101823,0.10980824609450095,0.870021716674458,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05849307059221724,0.05988704476267512,0.33250188913160794,-0.1782055673121078,0.061219426127673296,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06591760222892513,0.054058946090447556,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044879890684995455,0.19443970330022736,0.8182173434452141,-0.43355931936257097,0.3437995379925801,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2118002089016691,-0.06946062615310906,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05995345756498205,0.21313292055527336,0.779419996129309,-0.4860000950971114,0.3660931799671473,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10355703670646739,0.007950738369063728,0.9705004312583027,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06948326685640341,0.05477761270381014,0.20937552973315038,-0.17898215442240561,0.04001562070959881,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.024883780102258023,-0.04134068600038999,0.8231911614768439,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07287945654783169,0.06361583876023393,0.25635597621000417,-0.2000457062617273,0.054286793166063926,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1070997280531858,-0.010694751053376653,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14187158776883083,0.06874876503557437,0.043245860734290174,0.004444764631497428,0.27929841090616425,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10319793101546246,0.016328867707932765,0.4971708399879019,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09856262761324755,0.07499967957788378,0.19362910530907781,-0.2484848508760672,0.0513595956495721,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.13382113263723713,-0.030423671056532948,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11931259827791901,0.0811075879889778,0.14633745529084122,-0.042819159927326184,0.28144435648316424,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2100794843127106,-0.0690563960677896,0.7662201971017615,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04761375240061643,0.05865839642376836,0.4200621142620091,-0.16487021608658198,0.06964271128534913,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07400379973802607,0.016304116468372563,0.9279200175745067,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06302832111901126,0.05241144732872813,0.23371617356924454,-0.041740669257611426,0.16779731149563393,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05838505683579801,-0.00982105611950013,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04405841018700396,0.05246429579120651,0.40425901453155255,-0.14893304313483996,0.060816222760832025,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03852382899295213,-0.01314873508834793,0.923721375173133,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037038589809141674,0.061491407325191795,0.5491460924354223,-0.08588098197621438,0.15995816159449772,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02601638722204349,-0.003927374810024698,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09014272775391852,0.06377526361115954,0.16252666068455568,-0.21762766320392174,0.037342207696084706,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.005155204865407607,-0.03349801095555026,0.7815068115919459,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059969410686750074,0.07173526121542195,0.40637517532136747,-0.08342733324982762,0.20336615462332777,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.050920045410471904,0.04640319250259903,0.9239663408808872,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03487483198171605,0.05514301756312454,0.5294228092872875,-0.14510415345367336,0.07535448949024126,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11762923954332728,0.022043361503767577,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03442611652561216,0.0426921892567021,0.4231062826033596,-0.050914353798333756,0.11976658684955807,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16858834985983634,-0.12708501799151226,0.9288749656602147,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003017015958909421,0.05549334994676719,0.956817452075458,-0.10791260996944395,0.11394664188726279,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.054921152433521726,0.005933009275818018,0.995747388821315,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009085431482253287,0.07019972645373893,0.8974422206936513,-0.149412685166812,0.1312418222023054,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0021465628168596596,-0.03760656156139052,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043059513469674696,0.06133017985369051,0.4852484184956377,-0.1656567961317364,0.07953776919238699,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.008908276271013205,0.0022167533464695585,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06748599434527074,0.09554325183686416,0.48262290412570097,-0.12350224472136774,0.2584742334119092,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011362261029651299,0.0022954671486750677,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005481109682688592,0.04895789363983656,0.9112202989052856,-0.09238432523729428,0.10334654460267148,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.00128328011758316,0.03302549366346439,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00018722279436271657,0.06351456090814019,0.9976575316386577,-0.12715102096661665,0.1267765753778912,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0697974096258331,-0.028468230584404536,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13272034433322547,0.06912736723951526,0.05946923850150815,-0.2709039824925228,0.00546329382607183,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,0.3612254430561637,0.19909037535032578,0.5680556875544357,1.0 +ENTREZ:324,ENTREZ:84159,APC,ARID5B,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003152003879153542,0.0769334927671726,0.9967441903287355,-0.15347266035955612,0.15410306113538683,60,6,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14101852713493251,-0.11729352355056011,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01714045221643202,0.23386344441449305,0.9418092516149403,-0.4846268164763224,0.45034591204345836,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05363628923289958,0.0851528709343523,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21194219724699337,0.22070872000156477,0.3406443465515885,-0.6531326420910165,0.22924824759702978,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05704613021531319,-0.01940187632070333,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0069387191619767015,0.12927163374984432,0.9573662862019707,-0.25147159466433294,0.2653490329882863,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.031160206847485817,0.07440794558598496,0.9957512552242196,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21903218784769543,0.23261721370978342,0.35005234098747195,-0.6840273724252188,0.24596299672982794,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.014896116249610574,0.11830682230665035,0.9086977961712401,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021686281520677357,0.17777562965872393,0.9033039981332165,-0.37705470163114085,0.3336821385897861,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03917065786455341,0.13241815752563948,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08364111996882231,0.10791117171167515,0.44123134102317985,-0.13207023865251438,0.299352478590159,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03430294238380568,0.11637840749977924,0.9321782450874811,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023556690530175707,0.24503776138878686,0.923723470733733,-0.4662668150836306,0.513380196143982,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05906408970659577,0.17254627960396018,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02731745507349313,0.12190255219406458,0.8234221059344892,-0.270997184763103,0.21636227461611676,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.049110325507044486,0.05859615710459944,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0523577775092386,0.13244441324713255,0.6939644761782837,-0.31711038718045487,0.2123948321619777,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.010712031886115593,0.006994177846288597,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17839507693439505,0.22304587998377443,0.42687278422739405,-0.6242574380136054,0.2674672841448154,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.034346900464611224,0.08618957525500313,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03901739854940963,0.11812180543696457,0.7422755898838944,-0.2751395231584603,0.19710472605964102,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06789695653796182,0.16344795193470954,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18539869082940622,0.2274166001007756,0.4180567534081695,-0.6399979969314268,0.2692006152726144,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04135848511646199,0.05405297862955866,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0942594054913634,0.15424838349814607,0.5433750446545538,-0.40259753065259885,0.21407871966987202,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02407567236009415,0.08460611254073626,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052540791406277404,0.14945833780200812,0.726374159142958,-0.35130375165564476,0.24622216884308992,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013693216356243662,0.0594894364528919,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3655086514613712,0.15510943202134342,0.021624702582263133,0.05544931482748061,0.6755679880952618,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.15932928647650005,0.20910655185634286,0.34058906567064434,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3351862084325087,0.16893058368064207,0.05166849527137305,-0.0025012167009185182,0.6728736335659359,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11959760931471784,0.0093085343280904,0.5339911008653665,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05774168128097462,0.1196285550090472,0.6310266090204282,-0.29687575536792066,0.18139239280597144,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06474134798694998,-0.03559321824913379,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0768380959274682,0.1562480812222409,0.6246186894116631,-0.38917355988184565,0.23549736802690924,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07785100664900821,0.16034132593708805,0.9593389007132584,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1234623306268464,0.14464772186516842,0.39664669760606264,-0.41260900663908434,0.1656843453853915,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028616946266658245,0.03660598843593062,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13048201799082312,0.1379848106367287,0.34801026801184887,-0.40630972423688816,0.14534568825524194,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04561206304951979,0.07878254317809556,0.9086350165348037,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018986932787271957,0.2642770149732095,0.942956669809797,-0.5472691583253214,0.5092952927507776,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10433416122272804,0.10397235694552501,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12173337773276102,0.20007077371729629,0.5451107708832876,-0.5216691557844666,0.2782024003189445,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.016618554556487284,0.10068395464979399,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02246005919980226,0.10422015159753664,0.8300802833708245,-0.2307931737441788,0.18587305534457427,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0921312132391315,-0.040201735748742626,0.9817239773275311,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3292457447037684,0.1937157531882934,0.09421230659856103,-0.7164780177278348,0.05798652832029805,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.021953348900246566,-0.060334942603887276,0.6707240267079618,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16551816875435668,0.14448669017427054,0.25637985690589987,-0.45434294700315003,0.12330660949443664,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.016870490052412757,0.004217149200797762,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010885839911559047,0.10719195789956716,0.9194379122896178,-0.20338783078471676,0.22515951060783487,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11882618631408777,0.23390282034090087,0.9903757974905041,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11533711701884221,0.1230420794026588,0.3522006505478793,-0.3612947291413165,0.13062049510363205,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09388679569396022,-0.053158927861031956,0.9090812501778921,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0627522602664637,0.0989789921486265,0.528415835835406,-0.1351039258233111,0.2606084463562385,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.22099349408494512,0.31458038632048185,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08095120378530996,0.15872381556371845,0.6118532485970958,-0.3982355901720424,0.2363331826014225,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04581592937009881,0.02934451035724193,0.9549530254352627,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11030063787587074,0.10552386556183843,0.29995773627028494,-0.32123983950124524,0.10063856374950372,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12412119122124537,0.11529452170469415,0.8872737746993358,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05133917993375295,0.1134184193757434,0.6523786689502276,-0.27805936977281065,0.17538100990530478,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.033811069937780554,0.06054590790283358,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029502539830200132,0.24098379668471273,0.9029580874375833,-0.5112222854695037,0.45221720580910335,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.13350097273083197,0.06026157625253918,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14805000147963412,0.2148399302878536,0.49332014781633204,-0.5775089028464901,0.28140889988722184,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05071662598066658,0.019845831719264444,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014360183741627846,0.15310738094951365,0.9255771625057492,-0.29169710982402886,0.32041747730728454,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008093269176045685,0.0895930742706835,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1746344519154725,0.2238487771066563,0.43827392403207543,-0.6221017814744318,0.27283287764348685,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10078527242995158,-0.06829631812540386,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10839288144158934,0.11840555393107742,0.3635088562906359,-0.3450822112083727,0.12829644832519402,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2935820074423415,0.0969750287854654,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12851302008535037,0.1496756966141458,0.3938631962542276,-0.4277104744091571,0.17068443423845636,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.003245219461514096,-0.04766748219319961,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016231192921195986,0.11802112406990668,0.8910592313295967,-0.25215205834520193,0.21968967250280996,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.4541626667514421,0.20420931176153942,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0018661223797050712,0.09989126301831831,0.9851551470951936,-0.1978136671944029,0.20154591195381305,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06316417609357729,0.015939684458732818,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040110150184146424,0.09328352011877891,0.6687002265496682,-0.2265812499101956,0.14636094954190274,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020271370640037045,0.0672708499676635,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019158089147160016,0.12204690543594089,0.8757760615391371,-0.22481019856135204,0.2631263768556721,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0665423342915154,0.0642672699763777,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06745106140494897,0.10837328985949116,0.5359641711925145,-0.28408618104127403,0.14918405823137612,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.002519251225362705,0.024538012297474286,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003829759957464809,0.1288895549718991,0.9763909861272442,-0.2538167892744694,0.261476309189399,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.01211296802276315,0.036159503644444486,0.9980529036429133,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07295457761408881,0.11158027179309064,0.5156388592517627,-0.2960003627913199,0.15009120756314231,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0002808785873465072,0.05744118684180297,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05531997946737042,0.10325203694001957,0.5940301658153113,-0.15107790145140695,0.2617178603861478,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04227934147852353,0.12184725056971986,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11982102555395265,0.10440432049419963,0.255516732329314,-0.08888023736917665,0.3285222884770819,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0379881378987192,0.11194128722504997,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12636820524121062,0.13873932742608472,0.36591165862176345,-0.4037041690583218,0.15096775857590056,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0376102113326002,-0.017664327173162207,0.914684777397777,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035430435523633376,0.077846312072742,0.6506032842766754,-0.1201821250158695,0.19104299606313624,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027931838554970726,0.017511345922345677,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028045578719412562,0.08012887710191197,0.7275205070733963,-0.13212976429917755,0.1882209217380027,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02660115094779789,-0.00340777951733685,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049580157320048245,0.15561017776963734,0.7510873070694561,-0.26148015580195744,0.3606404704420539,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.022337232691528888,0.12678070291578486,0.9646550643928868,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08207164936823759,0.06289139291444254,0.19672433519213697,-0.043646453734287896,0.2077897524707631,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.2658350435767057,-0.11119493242546312,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06519460487735627,0.10787658485116411,0.5478199632329933,-0.15044761559495523,0.2808368253496678,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.2704655081257643,0.27818096288340843,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07182718240143028,0.2941184952544636,0.807873214830857,-0.5161073122449594,0.65976167704782,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.15201754778916418,0.11852367867286459,0.974516576191754,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1865522305025814,0.14146120219461616,0.19210258402794742,-0.4693291444549188,0.09622468344975599,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.25522011297878083,0.1105165209927687,0.813283143145888,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055616555199419944,0.17663501618522312,0.753919813307824,-0.2974718110655709,0.4087049214644108,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06112296950424082,0.16404284494805715,0.9654221498691481,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.3007828684215641,0.15072372406189474,0.050376845096270384,-0.6020752997624902,0.0005095629193619944,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004251069296402361,0.014849856193806063,0.5275612089369318,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.036042302551548,0.18329624708700393,0.844756985600134,-0.33036167455448523,0.40244627965758123,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.08238969545748752,0.023746157218901713,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.25371117747000665,0.19871520599068995,0.20644912949355126,-0.6509372142468165,0.1435148593068032,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.1337445761754648,0.1473448116964951,0.8202168117716766,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049322741880593476,0.16936279724391762,0.7718510506925969,-0.387874149616284,0.28922866585509704,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0638963911884823,0.028660070673295523,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13787233128499915,0.13235031410018927,0.3015854065304564,-0.40243683944169867,0.12669217687170037,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02447907242791918,0.025724260474962367,0.8896367821404172,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11221589669682924,0.08315003727688194,0.18206478971191004,-0.05399865945992144,0.2784304528535799,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.013575860800776086,0.07709761379802137,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11322924070357338,0.14051421269470996,0.4234262567253324,-0.39411314961866856,0.1676546682115218,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10204438473086219,-0.06415301780123081,0.9288749656602147,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09882099604889256,0.15984241050434456,0.5386816546783821,-0.41834142186103423,0.22069942976324913,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07355874016363641,-0.017000012492837953,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16843845321297723,0.20215583401497111,0.4079241660716133,-0.5725422074110319,0.23566530098507743,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.014540376841125689,0.0781618465367844,0.9246436408556443,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12347422971920217,0.17210803637433192,0.47580763481149946,-0.220564832845632,0.4675132922840364,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.024780222515140456,0.10943945606685619,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12797169570323927,0.1378868420951943,0.3569589137959648,-0.4036035656252117,0.1476601742187332,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.012847348727516117,0.00994470126584209,0.911668967477982,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054507782893745256,0.21817096351887977,0.803537220431298,-0.3816097590242237,0.4906253248117142,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04350394370886264,0.10019801862590212,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-7.318198786486312e-05,0.11485293153913395,0.99949364973972,-0.2296609207823782,0.2295145568066485,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.16028014247363323,0.16974740134890948,0.999766777543677,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03455352027828636,0.13985775960052577,0.8056766151731718,-0.3141251981558389,0.24501815759926618,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02225131016811618,0.04358104241833126,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00799775694131036,0.10163237802617664,0.9375302447421289,-0.2111579858240065,0.19516247194138578,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.022406299060474345,0.050742381026969915,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035284390012290764,0.10477262206166442,0.7374267763031642,-0.1741530972538794,0.2447218772784609,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.07805298333413875,0.1569003296933006,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06431283688323905,0.11709893319715978,0.5848286388273726,-0.2983902690193558,0.16976459525287768,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.08849398056668722,0.06765708619932109,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06793195889635578,0.11619840515540449,0.5609244509105882,-0.16434534333400228,0.30020926112671387,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004165736755426627,0.0921585169432186,0.9509691818071948,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21222777070302565,0.1951043258250553,0.28090919753480476,-0.602235760877311,0.17778021947125974,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06170729548845441,0.05947408126805853,0.8765161989116668,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054088598867518066,0.09701800596427548,0.5791857810643487,-0.13984763169444306,0.2480248294294792,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004139256116781576,0.05821288507227458,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1975799826320653,0.15207155055667007,0.19866661293425344,-0.5015666807459502,0.1064067154818196,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027655019033122626,0.007115868779344467,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0035041854518935264,0.12323192671357126,0.9774059895417551,-0.24283292603768017,0.2498412969414672,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.015951681981122828,0.024375609832188692,0.9982821339400993,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05421075171039151,0.088715203529586,0.5433904984763007,-0.231549916693853,0.12312841327306996,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.041150929119032814,0.0896458403918613,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014390915208123368,0.12015184452776255,0.9050504502742435,-0.25457103013814353,0.2257891997218968,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05696546840396939,0.021515061142997286,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002663093701578701,0.13883698447430481,0.9847579576198561,-0.2801942711765194,0.274868083773362,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.005156584764090644,0.044287704873572906,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0863956058378185,0.1366137733969547,0.5294458950370223,-0.35948264769278326,0.1866914360171463,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.023155249071925805,0.09797325711495039,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010477126905668252,0.08226064902982214,0.8990637159900621,-0.17491382128896216,0.15395956747762563,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09124282893342074,-0.06856957402738821,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021165023543467745,0.13315609349346988,0.8742257190146105,-0.2450102146694121,0.2873402617563476,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0004962247168664368,0.10408825076231458,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007464314993176378,0.09306397951345448,0.9363315378680832,-0.19349655930234974,0.178567929315997,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04462661171637663,-0.022760958973378983,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018489710865970108,0.13321622243758963,0.89006219247358,-0.2847851451254947,0.24780572339355444,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.026702819458645322,0.11483111068868794,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07777363259837736,0.10996706152801672,0.4820643199380744,-0.2975946564047398,0.1420473912079851,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11424936732107968,0.09020411024110525,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04031391486641336,0.27769126210847833,0.8850433891555238,-0.5954108383503118,0.5147830086174852,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09295802837767198,-0.013713504023882096,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05115535201972369,0.1719960193249417,0.767138845943466,-0.39497049569340476,0.29265979165395734,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04500737398739434,0.17465220702543707,0.9686101294099047,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19148129672319145,0.16608452480372987,0.2533710337460124,-0.5234795312258711,0.14051693777948823,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.046635220543792176,0.04696474992449234,0.8628310878918259,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12021412687002937,0.11162250294025854,0.28566624450113065,-0.102916077167522,0.34334433090758076,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.046609332479862986,0.062273487119447066,0.8772219144487331,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032223893366028454,0.1963515559067232,0.8701758308234031,-0.4247250609487552,0.3602772742166983,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0800810214078301,0.08116966227497799,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0630462859119825,0.1525021575459973,0.68073093253369,-0.36789375513256806,0.24180118330860303,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.002350473247773092,0.03488701023653256,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11061838060794947,0.15270982684669807,0.4715634781423532,-0.4158809748455981,0.19464421362969914,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.006460668697161343,0.10081090135992563,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1055276149300687,0.13042624463715935,0.4215529218385633,-0.36624596303337764,0.15519073317324028,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09574442033550984,0.060980822604174624,0.9282753503874777,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1827097301736002,0.177379309145078,0.30698773025548554,-0.5372859168656694,0.171866456518469,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.025180567612703604,0.08378271294079194,0.8959335604367346,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04465632448315292,0.08490183420496605,0.6007813111598697,-0.12506002383646447,0.21437267280277028,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.20881013785223645,0.20325091167242762,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03352879815772229,0.12784318563233077,0.7939865593076108,-0.22202608856811779,0.2890836848835624,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.037055709807167325,0.11125595346186778,0.9732342286065081,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1355239515310223,0.1722880436550881,0.4345050927256643,-0.47992284352294673,0.2088749404609021,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.042138220270967974,0.07242556119103996,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1338116075081718,0.17468356529086695,0.446569350949937,-0.4829990790184554,0.21537586400211176,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.026956186701651157,0.05756376788664334,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05344011744305508,0.08754364622712414,0.5438018213274571,-0.22843737274832282,0.12155713786221267,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0806770787844374,0.052527378820699334,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01765130293032599,0.11388547672741639,0.8773313444879529,-0.2100025212515471,0.24530512711219907,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06655126911178019,0.09250615744890119,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07167487214919557,0.10117501589476526,0.48133671399743194,-0.13057110285983953,0.2739208471582307,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03893056950054126,0.06045969174461796,0.9396519533333579,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030965041728657244,0.08952321168257575,0.7305975392838049,-0.209919391995476,0.1479893085381615,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006278587354865931,-0.002889157622041018,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21204003353134243,0.10837911435484257,0.05491827281295505,-0.004606729105291252,0.4286867961679761,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.14492647170303258,0.09514496157555763,0.5490443949486614,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06641153349189974,0.09258377798756558,0.475874981772351,-0.25148386862838523,0.11866080164458576,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.013597307523571469,0.023864523160767467,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1571044155904382,0.1005421865749604,0.1232435739763312,-0.043876551633163396,0.3580853828140398,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.056876914852252554,0.13612991861990223,0.7246722149808276,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043748916372181895,0.09384024771931035,0.6427016959908478,-0.14383506597007595,0.23133289871443974,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02496580683992374,0.033469401981625194,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17613581641271014,0.11368288140474547,0.1263848104977076,-0.05111302548965957,0.40338465831507986,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09790666952253288,0.12179826695696841,0.7263564310373228,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03924810697199544,0.09676972000320881,0.686445637004377,-0.23268802096970503,0.15419180702571417,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06939009824881157,-0.07243785342970957,0.9631430579652833,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023415363955409736,0.0709376794571922,0.7424495476432432,-0.1183870367639613,0.16521776467478078,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07383369542466885,-0.03108968472438674,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009694830229609945,0.10920661101950005,0.9295467695047834,-0.20860607467011413,0.22799573512933405,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03656430719171679,0.06845195048047348,0.9916960348989801,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0012389435866497478,0.11311855726286735,0.9912964224855216,-0.2273597176030308,0.2248818304297313,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.012068686129410798,0.09758794995166592,0.9992761255456871,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09999672852231535,0.22893608780461877,0.6637819689960684,-0.35763999022017023,0.5576334472648009,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03465101128955681,0.28094264443508027,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2751637370648121,0.1623218844190622,0.09505975868947399,-0.5996405606097016,0.04931308648007737,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05679997971194765,-0.004735059387469707,0.6731350262953119,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00021432737130733367,0.07235645181938412,0.9976460963621716,-0.14485281363185418,0.1444241588892395,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.020931878085012783,0.027132345835702863,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037366864301088654,0.15495114438746066,0.810232618567013,-0.347109788463349,0.2723760598611717,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.029046846358934553,0.1091840444787493,0.9747331744048557,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04650104944948196,0.13728757724839957,0.7359706114763152,-0.3209350060115524,0.22793290711258846,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03967433396455205,0.09315965804341428,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06069616195750626,0.14637626818766034,0.6798231999366318,-0.35329815283427835,0.2319058289192658,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.003068103789997605,0.10709743181186271,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058351847836702525,0.14543047026148836,0.6896264097843754,-0.34906321559818754,0.23235951992478251,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.048415323564143936,0.022887584296376787,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11024662378297563,0.15322405658475968,0.4745287093346524,-0.4165371486202209,0.19604390105426966,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.013991782501316401,0.011732108706162456,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03508279553007374,0.11262095280778829,0.7564563922082138,-0.19004328135385537,0.26020887241400287,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02077910879668249,0.11211657540860762,0.9657045418701836,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2895590793741646,0.20416761239050937,0.1611271294385704,-0.697684321243504,0.11856616249517477,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04624192944622147,-0.0007824214800106602,0.7815068115919459,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11008335746297859,0.171600921394866,0.5235573032991685,-0.4531087116279994,0.23294199670204224,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.14454465912561132,0.15666123956462305,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.28792424736489125,0.14460466030455899,0.05087969477742788,-0.5769848445439919,0.001136349814209403,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09224642318989441,-0.11908269517792311,0.5306536293719093,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007731827478590275,0.20365230153130032,0.9698369135769562,-0.41482697761795273,0.3993633226607721,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06444179796337132,0.1451344704922549,0.9969763314031036,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13266264029921432,0.14712409622522626,0.3707028398770065,-0.4267595181227196,0.16143423752429098,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06114050277770714,0.09124421314515146,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07591146090408941,0.1225740978374671,0.5379808336043217,-0.3209335912072488,0.16911066939907,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.01834153459054076,0.045908760169180905,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016162244487214227,0.08649664655751506,0.8523852014059665,-0.15674208830016162,0.1890665772745901,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09608168860917013,-0.007355657474382074,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02500838854505946,0.062498404382671846,0.6904255203737382,-0.14994091876605456,0.09992414167593563,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07711711052961402,-0.03532375969930093,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023942678203249777,0.10311519378323371,0.8171524515792091,-0.23006701354931128,0.18218165714281173,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03104653372909167,0.06144719823515628,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2423068917437126,0.1797390849194628,0.18252993902479167,-0.6016002029953624,0.11698641950793723,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.043782741337671294,0.12090870933956535,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11009727770417968,0.06826520702729293,0.11186974166951473,-0.02636292674776572,0.24655748215612508,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11678226388130832,-0.026008867301973167,0.7058998484678919,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014780968487983095,0.08068390231048593,0.8552420049656139,-0.1760657910897481,0.1465038541137819,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.043175477574509305,0.04256664211151305,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011750327725049511,0.14704022031173478,0.9365643616843726,-0.28217888453642115,0.3056795399865202,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.05636320381070241,0.16720325962585847,0.9921544029542516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028027348809403194,0.10484701632211267,0.7901126196100141,-0.23761354808324017,0.1815588504644338,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.030323056550835035,0.021304727408750137,0.972929334907502,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008890677698723527,0.098047744739209,0.9280415470154535,-0.20488532674176163,0.18710397134431456,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10686937355258165,0.15575986998463615,0.9916764739841218,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01989416895563986,0.08012775671435775,0.8047378153983521,-0.14027893444014133,0.18006727235142106,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007574550203199652,0.04543171720667843,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01541109920243591,0.11568049601166339,0.894449875868082,-0.21583091740117255,0.24665311580604438,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.028774247521826807,0.094149179866969,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16598745027419085,0.205125090747469,0.4214940747285074,-0.5760266641072684,0.24405176355888672,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.017337438745002088,0.09665037034494828,0.9282753503874777,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09471263072234204,0.21102741426882343,0.6551286995450232,-0.5165504211589232,0.32712515971423917,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.02322744688941807,0.036966817829071394,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07949701623124747,0.06844123634058914,0.24987593090128948,-0.05731506580414,0.21630909826663494,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.016225494742567508,0.07286662811742595,0.8577585765822857,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14619556790761537,0.24744799685004812,0.5567932257390833,-0.6408370655578267,0.34844592974259603,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06368159071666105,0.0651603696156164,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025878735367310286,0.13367067233676408,0.847121428988649,-0.29308260203120323,0.24132513129658267,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.02121021247406279,0.1292621559368349,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10020002816246397,0.15550310145915824,0.5217187052907083,-0.21064624246474495,0.4110462987896729,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05721974912589716,0.11762116813170369,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10480973046587638,0.1584411324773128,0.510739011133067,-0.4215290414145369,0.21190958048278413,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.11381432014120094,0.14372840793199065,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14136166104896417,0.16056663295147097,0.38204667473425913,-0.4623297869049078,0.17960646480697942,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.24761376876031935,-0.1219278798633187,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039227519162834054,0.20009604221313132,0.8452172987268392,-0.43921380821799216,0.360758769892324,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10058230723955926,-0.015414647621948918,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.25476745390885003,0.16091015231224196,0.11844350462197725,-0.5764222651825244,0.06688735736482426,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06444439727630889,0.041613293170478,0.7204222518350135,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2000917247670668,0.15405382442966672,0.19880772243332018,-0.5080409318920315,0.10785748235789785,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.007721834024103596,0.03884423115940943,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02989279809637101,0.16867897517529526,0.8599155519517279,-0.3670772649941666,0.30729166880142456,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.10580142522485184,0.029467052570757813,0.9841421066021938,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.5447171273485408,0.18795870732159625,0.005184297484179911,0.16899302503425678,0.9204412296628248,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.7101736656025317,0.8949319695662747,0.13594586142399853,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.103214681498084,0.12510447640642516,0.41251885260357435,-0.3532949664879022,0.14686560349173422,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10158371871635183,0.14863356719718887,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07301420282943519,0.12348218594742932,0.5564735847432891,-0.3198515753993657,0.17382316974049536,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10122809801838809,0.13263168376263051,0.949991921327294,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.101671171267613,0.13561027064449105,0.456252482726372,-0.16940989716791233,0.3727522397031383,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12231449913562123,0.06545943818152676,0.9353647231100054,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059443233241858684,0.10832310389991187,0.5851419770783719,-0.2759780325744298,0.15709156609071245,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.03385180378461001,0.11138403802490986,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06602115450189834,0.1554294309247978,0.672477685805646,-0.24467785082547944,0.3767201598292761,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.163449686340232,0.034039015732322195,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11285990601842366,0.14496526898320677,0.43921746086778723,-0.176921537638089,0.4026413496749363,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.12654003210422132,0.08486537153093038,0.9304126176629784,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0009848903528511493,0.1402504396468373,0.9944195531628703,-0.28134152445828786,0.27937174375258556,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.018395608788377996,0.11534440742299756,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02502179277580166,0.08144016984941249,0.7596892675456415,-0.13777478709553445,0.18781837264713777,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05765330503374837,-0.03694489363659899,0.9673425418314568,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0014763081617271822,0.14650889384321883,0.9919925448785117,-0.2913907976229342,0.2943434139463885,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.035878140176688306,0.13834441222865232,0.9994099232379783,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003390791658563054,0.12743762909938347,0.9788582805465329,-0.25135339910936855,0.25813498242649463,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.06776649655070796,-0.002478109699201092,0.9984157213799838,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10514529282170884,0.2672193167838351,0.6953153309615561,-0.6393090958737147,0.429018510230297,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.0071412098331762935,0.16336349049370907,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019384689231356653,0.17001459594928187,0.9095921098239536,-0.35923902401390956,0.3204696455511962,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07040162886584947,0.055169347153381884,0.9890879681893895,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13376329671806408,0.168972526158339,0.4315961713917187,-0.4715345636697612,0.20400797023363304,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.062181267621314304,-0.05165454245704134,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09942157757364183,0.18029418831375985,0.5833135416455231,-0.4598245246995,0.26098136955221635,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.011636589680701808,0.14873444388606089,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05012120246552843,0.10205223366826235,0.6250665618941066,-0.2541207108180197,0.1538783058869628,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.0631297544717126,0.0856989575007451,0.9595394253172342,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03850968453811847,0.19474707721011622,0.8438937936179431,-0.427803544906641,0.35078417583040405,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.20693004962905423,-0.1004086527292983,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050952928561395376,0.26206381526715194,0.8464752974166931,-0.4729051738027384,0.5748110309255291,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.11023368094362239,0.11170735307746087,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022459411236110585,0.09094814122855813,0.805764774180529,-0.2042621550791274,0.15934333260690622,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.027722112246379528,-0.010004415021734084,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029156526055362758,0.10683994993636933,0.7858377029001461,-0.18441349074871166,0.24272654285943718,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.09779164951003136,0.07930491135179514,0.9722536916492144,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11733332650133901,0.0711409871569327,0.10414295456878492,-0.02487548051900687,0.25954213352168487,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.09997070060468966,0.0008620164411837869,0.686265063428165,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003237081983013637,0.10045057808111725,0.974395645408977,-0.20403492643670446,0.19756076247067716,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.12427277855923903,0.05321728795629081,0.998018743752871,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18446885824672068,0.07344380549624545,0.014633595172734415,0.037656782957186524,0.3312809335362549,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.21027046447538136,-0.03852182043422215,0.2640033601844677,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01865110896217406,0.10097871851210889,0.8540645573334817,-0.18320247317006277,0.2205046910944109,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.06834411454795675,0.07381233913328755,0.9832743004559027,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08064227515410524,0.08295902746255927,0.33479122394961425,-0.08519045782434059,0.24647500813255108,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.05904809742970551,0.007980839269430917,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01997541203545788,0.09045667970652817,0.8259515958189745,-0.20079573829421893,0.16084491422330316,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.04037726343128887,0.014538183840281143,0.980692368074751,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12765499537857133,0.07495232250116651,0.09354859617103183,-0.022172562436760523,0.2774825531939032,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.03116379231728132,0.0632887698342806,0.6704521782043941,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054123567910444786,0.08598783833515668,0.531378354853355,-0.22601080755369385,0.11776367173280428,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.008428792873180302,0.0007712015212481341,0.9462574637850627,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11891559296132688,0.058237946023784695,0.04542240860600557,0.0024995976492539623,0.23533158827339978,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04707725400195547,0.09238187710492493,0.5099902114773299,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05573414749950035,0.10311714098639715,0.5907931861885415,-0.15039408025022277,0.26186237524922346,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.10939175968709679,0.10342344014186775,0.953309951095112,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03944536099642864,0.054611874878194556,0.4728346295728363,-0.06972222137687298,0.14861294336973027,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.16784439700398712,-0.12786057645920793,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06378657542911838,0.09824640449900846,0.518574168009047,-0.1326051888153395,0.2601783396735763,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.04955356908667467,0.06161989747581141,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05427994573930602,0.0865151407203146,0.5326983488866195,-0.11866135635273747,0.22722124783134953,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.006976430400470604,0.01422582320975684,0.9463401736865253,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015404710385094488,0.09188058303671624,0.8673963503105525,-0.1990713788439105,0.1682619580737215,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.006746211294555537,0.027255641474344394,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16367552152226256,0.06304180101073462,0.01175162881555695,0.037656756919317996,0.2896942861252071,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.004572701883183933,0.08331472995938169,0.22587028943799292,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04918108776561486,0.1000159867912322,0.6246451122225671,-0.15074802107804494,0.24911019660927466,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.004163212087209344,0.0750224184491134,0.9593389007132584,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06877521761008698,0.10687668773537846,0.5222724830492333,-0.1448682370078052,0.2824186722279792,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.07352726016332317,0.025301781781260097,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05839850696479475,0.0954931615318877,0.5430738315459986,-0.2492866169385058,0.13248960300891627,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,0.34654187676966125,0.34580287050448855,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:55252,APC,ASXL2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07362289164793193,0.13522101920720278,0.5880756090911083,-0.19668007425148984,0.3439258575473537,61,5,66,2,log_other_mut_burden|lin_Uterus,False,62,-0.1396163378422328,-0.12965523220462224,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16736265740409395,0.08494440430423573,0.051782708883527366,-0.3360454095899704,0.0013200947817825492,84,12,96,1,log_other_mut_burden,False,93,-0.17106899328085132,-0.3257489236885929,0.5339911008653665,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022508739613475076,0.08746381202904949,0.7974777851660052,-0.15117705700341344,0.1961945362303636,84,12,96,1,log_other_mut_burden,False,93,-0.21769129121254055,-0.17829149632517816,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10358386022139457,0.07006557347499133,0.1426838826328971,-0.24272020315121295,0.035552482708423816,84,12,96,1,log_other_mut_burden,False,93,-0.3118219192208705,-0.41167480250361327,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04661193861983556,0.10009840233706878,0.6425467501390008,-0.15216365035423382,0.24538752759390495,84,12,96,1,log_other_mut_burden,False,93,0.0890701255378674,0.16875909367323697,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03612199187183379,0.06961268044140688,0.6050633511633994,-0.17435897899385558,0.102114995250188,84,12,96,1,log_other_mut_burden,False,93,-0.18107314438542174,-0.20508101560349942,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10694832334507881,0.06240931902398882,0.08992273458165072,-0.23088086229500313,0.016984215604845504,84,12,96,1,log_other_mut_burden,False,93,-0.4319595850099914,-0.5394095679381474,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012160501914208977,0.09967762507523782,0.9031635870244883,-0.18577950680988103,0.210100510638299,84,12,96,1,log_other_mut_burden,False,93,-0.12101331312883974,-0.09192728996848253,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17763932068482302,0.053984578112560945,0.001413543661517076,-0.28484199384744036,-0.07043664752220567,84,12,96,1,log_other_mut_burden,False,93,-0.4692864127628855,-0.642460169216357,0.048365127522079956,0.4622107861525674 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04664664727061809,0.04683710459148837,0.32186667224736526,-0.13965585454710078,0.046362560005864605,84,12,96,1,log_other_mut_burden,False,93,-0.08793762438574593,-0.12499272987902339,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0465033108408614,0.10449300641392019,0.6573267358026631,-0.16099909088235106,0.2540057125640739,84,12,96,1,log_other_mut_burden,False,93,0.07023335278686804,0.13912837597023156,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0487894882366169,0.05407383550626269,0.36924156313783896,-0.15616940889359096,0.058590432420357164,84,12,96,1,log_other_mut_burden,False,93,-0.20089072320963075,-0.23704220768398718,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08347554616478578,0.11260851217428082,0.46038549582833566,-0.1401426416216848,0.3070937339512564,84,12,96,1,log_other_mut_burden,False,93,0.11983299312438363,0.23147984230391305,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05721209970227209,0.07003373443032554,0.41606078742187946,-0.1962852165994261,0.08186101719488192,84,12,96,1,log_other_mut_burden,False,93,-0.12534855402719122,-0.1698326307532407,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07166481628522882,0.04958370982854172,0.15172655430353496,-0.1701282372247438,0.026798604654286157,84,12,96,1,log_other_mut_burden,False,93,-0.2017942630792491,-0.2664137948947294,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009997011378844761,0.042948672297985296,0.8164542486458631,-0.09528456275192816,0.07529053999423864,84,12,96,1,log_other_mut_burden,False,93,-0.2634626739963085,-0.26962122718715703,0.978118597306197,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045161880900884244,0.06468301465944387,0.4867923460073973,-0.08328576696719689,0.17360952876896538,84,12,96,1,log_other_mut_burden,False,93,-0.915335663886119,-0.8618899957014948,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00219036787661777,0.041924125725126285,0.9584447395807503,-0.08544337280643596,0.08106263705320041,84,12,96,1,log_other_mut_burden,False,93,-0.0055730641352341615,-0.0013541913094554114,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03964394089609169,0.06168483651364506,0.522009611447454,-0.16213780116251353,0.08284991937033016,84,12,96,1,log_other_mut_burden,False,93,-0.22469474530852387,-0.2526853132970546,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010044236818890322,0.06084504874036093,0.9868645671243075,-0.11982178450067976,0.12183063186445783,84,12,96,1,log_other_mut_burden,False,93,-0.04790490679393447,-0.04013982277849546,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09799781652935442,0.06757447209051236,0.15036162181794585,-0.23218732581015505,0.03619169275144622,84,12,96,1,log_other_mut_burden,False,93,-0.20437977167375795,-0.2920294612357119,0.7680634195565342,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11743475041529813,0.0926179444363056,0.20798167672502405,-0.30135563251789443,0.06648613168729817,84,12,96,1,log_other_mut_burden,False,93,-0.12259193487966615,-0.22539963687843004,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08174520410189907,0.09878116575147856,0.4100504336154148,-0.11441461407058258,0.27790502227438074,84,12,96,1,log_other_mut_burden,False,93,-0.2603639333682729,-0.1616215312082113,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14464031925503162,0.06296228800884363,0.023847685347290308,-0.26967094501835753,-0.019609693491705688,84,12,96,1,log_other_mut_burden,False,93,-0.3116920785450022,-0.44994240526129653,0.3634085581572868,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1870530602637654,0.09826495612817919,0.06006006831179393,-0.00808166790218559,0.38218778842971635,84,12,96,1,log_other_mut_burden,False,93,-0.06808067788619818,0.15231556140657884,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011321124853136369,0.05877792615944282,0.8476856124594672,-0.12804243726404274,0.10540018755777002,84,12,96,1,log_other_mut_burden,False,93,-0.20930385173372387,-0.206915082042909,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06223562232277527,0.057520422234390044,0.28206144937310995,-0.17645978115776484,0.051988536512214314,84,12,96,1,log_other_mut_burden,False,93,-0.30763563679791506,-0.3640268186192172,0.8770089248428307,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05859198482283437,0.05472002143668442,0.2870485943665881,-0.16725510267284463,0.05007113302717589,84,12,96,1,log_other_mut_burden,False,93,-0.2953740747685208,-0.34560270254293707,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07896900003655971,0.05329403835834409,0.14178450276611795,-0.1848003981023753,0.0268623980292559,84,12,96,1,log_other_mut_burden,False,93,-0.38403175484579405,-0.45528486055791134,0.7604630965928677,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07685092737482327,0.05680846681316793,0.17939688936303766,-0.18966128384261666,0.035959429092970105,84,12,96,1,log_other_mut_burden,False,93,-0.22273884480428152,-0.29380274503165243,0.7982357106299288,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002293465669319171,0.05400590117551935,0.9662175044956025,-0.10953848220904674,0.10495155087040839,84,12,96,1,log_other_mut_burden,False,93,-0.08274867758386002,-0.06733548277867892,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04448594343306063,0.043975075505047125,0.3143458540369511,-0.13181172815697778,0.04283984129085652,84,12,96,1,log_other_mut_burden,False,93,-0.10205878744266059,-0.1332206336960332,0.9017988396622038,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037486061547595435,0.09812818315696427,0.7033246063557128,-0.23234918569915433,0.15737706260396347,84,12,96,1,log_other_mut_burden,False,93,-0.09697287766231621,-0.12048715529673269,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06321140786386992,0.09976726898232138,0.5279044817476928,-0.13490661589355168,0.2613294316212915,84,12,96,1,log_other_mut_burden,False,93,-0.06678005791587445,0.01869033025975918,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10082077758392123,0.051448114117502435,0.053029634228967226,-0.20298653594312854,0.001344980775286067,84,12,96,1,log_other_mut_burden,False,93,-0.05603695168333719,-0.15184788622210857,0.5410658566960692,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007654741085986145,0.08614318086236777,0.9293837166621708,-0.16340854376402417,0.17871802593599648,84,12,96,1,log_other_mut_burden,False,93,0.027824285723914495,0.048051737021095164,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01989753957103982,0.05929050142289322,0.7379328998140788,-0.13763672487009482,0.09784164572801517,84,12,96,1,log_other_mut_burden,False,93,-0.2958357428720527,-0.3153833389848277,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10359123788367375,0.056086198452599406,0.0679267810078705,-0.21496731253060555,0.007784836763258057,84,12,96,1,log_other_mut_burden,False,93,-0.15463682103999252,-0.24089991397565347,0.6004485385751404,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10420280317213396,0.04756044401230386,0.030953979127291087,-0.19864841918285991,-0.009757187161407999,84,12,96,1,log_other_mut_burden,False,93,-0.3971829502465941,-0.5008295643408406,0.42002168600416523,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09904305054314654,0.041522793225671234,0.019094934759786155,-0.18149908866739095,-0.016587012418902133,84,12,96,1,log_other_mut_burden,False,93,-0.2808907677442375,-0.37403330106482896,0.3154853684987219,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043199896870675346,0.04819453955154424,0.372372271642451,-0.13890470095369345,0.05250490721234275,84,12,96,1,log_other_mut_burden,False,93,-0.17876873805949706,-0.21827370790980508,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06830340909216802,0.04015886538813299,0.09231650226225599,-0.1480509568419922,0.011444138657656172,84,12,96,1,log_other_mut_burden,False,93,-0.2706294476661587,-0.3319071629494129,0.6674195391201606,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020918627082670956,0.04669230598048525,0.6551878089282539,-0.1136402930147089,0.071803038849367,84,12,96,1,log_other_mut_burden,False,93,-0.02580521232672092,-0.03352055215629473,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08065330440709634,0.05371976296772532,0.13664730316976317,-0.18733010717463286,0.026023498360440184,84,12,96,1,log_other_mut_burden,False,93,-0.0938655119226463,-0.174285612814849,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03095525245657174,0.04659731727061354,0.5081331009304281,-0.12348828963620408,0.061577784723060594,84,12,96,1,log_other_mut_burden,False,93,-0.1738832615056302,-0.19747711466480056,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02583129244753763,0.05062003720392118,0.6110519215837702,-0.1263526541693374,0.07469006927426211,84,12,96,1,log_other_mut_burden,False,93,-0.13274779899765918,-0.15724543295225626,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07308906623940681,0.03725424783580493,0.0527641314108939,-0.1470686191838372,0.000890486705023591,84,12,96,1,log_other_mut_burden,False,93,-0.10485862750626869,-0.1720086202078193,0.5404408711479688,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047092412353522704,0.04592806177579142,0.3078569443985932,-0.13829644075727637,0.04411161605023096,84,12,96,1,log_other_mut_burden,False,93,-0.047254526147520584,-0.08481107109657647,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0803156932476203,0.03716097181144648,0.03324110379514376,-0.15411001849364472,-0.00652136800159589,84,12,96,1,log_other_mut_burden,False,93,-0.011701577606875135,-0.08525995555540973,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07892738142492114,0.0432502247466216,0.07122632689320343,-0.16481375619762695,0.006958993347784659,84,12,96,1,log_other_mut_burden,False,93,-0.07481890367261612,-0.15111538069168548,0.6185936355341891,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07834399959093265,0.04507964088279564,0.08553811449549718,-0.16786323224604638,0.011175233064181084,84,12,96,1,log_other_mut_burden,False,93,-0.17150254760359548,-0.24540501233808384,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12658380980770745,0.037016853254204785,0.0009327474220736267,-0.2000919441612804,-0.0530756754541345,84,12,96,1,log_other_mut_burden,False,93,-0.15274226853605266,-0.27433704472799714,0.03412050247198364,0.3260792450985756 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04497814541113532,0.03796080996932394,0.23909288036733015,-0.12036079072225582,0.030404499899985185,84,12,96,1,log_other_mut_burden,False,93,-0.5824440248408489,-0.6209272585834306,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007421682691787779,0.10845544590279922,0.9455896946711723,-0.22279270394125178,0.20794933855767622,84,12,96,1,log_other_mut_burden,False,93,-0.18503503004758454,-0.18036841453997188,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017385884839690183,0.0582150849115658,0.7658740579033813,-0.1329895060793737,0.09821773639999336,84,12,96,1,log_other_mut_burden,False,93,-0.2604458957898976,-0.26750542475416045,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-7.301518693599712e-05,0.060800507233444406,0.999044394767282,-0.12081077276425625,0.12066474239038427,84,12,96,1,log_other_mut_burden,False,93,-0.09538322997059985,-0.0909991848691291,0.9996899238181953,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04960864675617103,0.06271179043265367,0.43092310672687706,-0.17414183397820973,0.07492454046586766,84,12,96,1,log_other_mut_burden,False,93,-0.050567197122945384,-0.08402835931511844,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0815033995486371,0.05129443231230762,0.11546962907829716,-0.18336397630025658,0.0203571772029824,84,12,96,1,log_other_mut_burden,False,93,-0.22006301395819597,-0.2934985995164024,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19992749039670038,0.09757281171126321,0.04327853998886876,0.00616722386965049,0.39368775692375024,84,12,96,1,log_other_mut_burden,False,93,0.07154392194013821,0.2886845991773413,0.4971708399879019,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006778609802984489,0.055553679686483094,0.9031471711485248,-0.10353998811202035,0.11709720771798933,84,12,96,1,log_other_mut_burden,False,93,-0.04977723791937164,-0.026782841623621764,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04542385030556338,0.054687299792795525,0.4083209499649044,-0.15402198945577072,0.06317428884464395,84,12,96,1,log_other_mut_burden,False,93,0.021309075894354785,-0.013300030503964333,0.9252788183903543,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05620796903476333,0.04730186516211738,0.23774788529338226,-0.15014009869563752,0.037724160626110864,84,12,96,1,log_other_mut_burden,False,93,-0.34950172529850143,-0.4021267014208448,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020258196995914655,0.047583998270859205,0.6712842336639846,-0.11475058709601538,0.07423419310418608,84,12,96,1,log_other_mut_burden,False,93,0.08628470405116156,0.0784270851258162,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06853778359391442,0.059161521424136644,0.24963207013654806,-0.18602084017742426,0.04894527298959543,84,12,96,1,log_other_mut_burden,False,93,-0.2021758681664732,-0.26345259647005,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014579822289522409,0.09365380618211135,0.8766243760440007,-0.2005577205263512,0.1713980759473064,84,12,96,1,log_other_mut_burden,False,93,-0.01587723114867832,-0.011794808164724913,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08474100859985187,0.07664200031983802,0.27172008548462223,-0.23693683189007939,0.06745481469037565,84,12,96,1,log_other_mut_burden,False,93,-0.2546436944130162,-0.3290166554926734,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08076418693860515,0.058028844292237244,0.16730465671891392,-0.19599797121852114,0.034469597341310845,84,12,96,1,log_other_mut_burden,False,93,-0.35599028075880074,-0.4323188145290728,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05781878255102116,0.07328862213072924,0.4321659683557596,-0.20335546134912877,0.08771789624708645,84,12,96,1,log_other_mut_burden,False,93,-0.10862826013039914,-0.15751271570156433,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11166118042203871,0.05211911140742749,0.03477118780557981,-0.21515940641700032,-0.008162954427077096,84,12,96,1,log_other_mut_burden,False,93,-0.570601670198783,-0.679935081625807,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04227772152358289,0.07045597412322308,0.54992645862021,-0.18218932276898164,0.09763387972181586,84,12,96,1,log_other_mut_burden,False,93,-0.4050943579686868,-0.4388411210072621,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13398215566729202,0.06721493528820743,0.04915438461939223,-0.2674576961137515,-0.0005066152208325903,84,12,96,1,log_other_mut_burden,False,93,-0.4606546843534967,-0.5926450092682257,0.5240813480471289,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06679493234181105,0.04171447167824619,0.11271503566659365,-0.1496316058849498,0.016041741201327703,84,12,96,1,log_other_mut_burden,False,93,0.027900913623520197,-0.029240468865040045,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07777696707954956,0.04855331669087149,0.11257179991279678,-0.17419423145678953,0.018640297297690386,84,12,96,1,log_other_mut_burden,False,93,-0.11348366212469228,-0.1861234545803354,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09514217553240058,0.05738048711579737,0.10066814224449949,-0.20908845095499815,0.01880409989019699,84,12,96,1,log_other_mut_burden,False,93,-0.193326172366606,-0.28371997605012783,0.6818291067720451,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0034351050578327394,0.08381789482052718,0.9673973400418132,-0.16301062255141752,0.16988083266708298,84,12,96,1,log_other_mut_burden,False,93,-0.028989447505874986,0.001238796184187137,0.9962636332708761,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08781263903367358,0.056563217613742126,0.12394662123177332,-0.20013597919628032,0.024510701128933166,84,12,96,1,log_other_mut_burden,False,93,-0.3486857378454895,-0.4337900682413198,0.7255813269452924,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008385437328658343,0.06404025462536957,0.8961055262882127,-0.13555669115488575,0.11878581649756906,84,12,96,1,log_other_mut_burden,False,93,0.06065192250375106,0.07369638552768502,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04809617738059258,0.047744541357175006,0.3163732645767009,-0.1429073742327799,0.04671501947159474,84,12,96,1,log_other_mut_burden,False,93,-0.03946706762018714,-0.07832547394329818,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03806268718126118,0.04813708605997029,0.431122476653811,-0.13365340001647122,0.05752802565394886,84,12,96,1,log_other_mut_burden,False,93,0.032013421147336976,0.008830221070136738,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029038458542504794,0.03923135408420427,0.4610523199306228,-0.10694415266216106,0.048867235577151474,84,12,96,1,log_other_mut_burden,False,93,-0.09101123586344492,-0.11164885676670949,0.9369772953428787,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0795540338141871,0.033711567311564786,0.020373050631303985,-0.1464985253459338,-0.012609542282440406,84,12,96,1,log_other_mut_burden,False,93,-0.005478152428608799,-0.08492174162749422,0.3287017803075021,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045420724745154045,0.05434833063556193,0.405446846501181,-0.15334573832791962,0.06250428883761153,84,12,96,1,log_other_mut_burden,False,93,-0.06527999088287617,-0.09385102981422384,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09726848205817179,0.04137750229431443,0.020847865621533426,-0.17943600118731984,-0.015100962929023728,84,12,96,1,log_other_mut_burden,False,93,-0.03233357920939479,-0.12261891171668358,0.3333341305877653,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0845663411984138,0.03905247932757517,0.03291156697144645,-0.16211682550181533,-0.0070158568950122735,84,12,96,1,log_other_mut_burden,False,93,-0.10257715201461604,-0.1811091313511094,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011139089773282276,0.03374036327754655,0.7420356763707294,-0.05586258483995686,0.07814076438652141,84,12,96,1,log_other_mut_burden,False,93,-0.018062829451401984,-0.00830641808794534,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0679218294853979,0.049463818272804765,0.17300373616881942,-0.1661471695560057,0.030303510585209886,84,12,96,1,log_other_mut_burden,False,93,-0.14244352685147166,-0.20121199670034082,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09430304488233873,0.04688408365589025,0.047176674804939464,-0.18740554327014697,-0.0012005464945305105,84,12,96,1,log_other_mut_burden,False,93,-0.11292907411290805,-0.2014446033574442,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10569471162289447,0.08748057719979846,0.23003065494123692,-0.2794138005462741,0.06802437730048518,84,12,96,1,log_other_mut_burden,False,93,0.296659510208795,0.2171661377662696,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04993607626947049,0.062044328339629265,0.42296187572448163,-0.17314381605617427,0.0732716635172333,84,12,96,1,log_other_mut_burden,False,93,-0.06453511234671748,-0.0955159516207222,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012196063361525483,0.05653830600303223,0.8296836506350023,-0.12446993400238625,0.10007780727933528,84,12,96,1,log_other_mut_burden,False,93,-0.08961735810820853,-0.08422750697277771,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07088236857567809,0.032411774128037,0.03125585203350397,-0.13524572844530097,-0.006519008706055193,84,12,96,1,log_other_mut_burden,False,93,-0.23841385146954833,-0.303951878725399,0.42195400245230363,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049851412638184794,0.07651967493693748,0.5163402132711191,-0.20180432196110787,0.10210149668473828,84,12,96,1,log_other_mut_burden,False,93,0.053206839621024384,0.01873001884229213,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08786079330523246,0.05275964242177916,0.09921769783624719,-0.1926309869506384,0.016909400340173478,84,12,96,1,log_other_mut_burden,False,93,-0.08958157915800298,-0.16917115928921034,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008972740049037933,0.06053662430011872,0.8824900281598359,-0.12918647841858516,0.11124099832050928,84,12,96,1,log_other_mut_burden,False,93,-0.13681569422431628,-0.13198859333403465,0.9870366109823806,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07801944130222492,0.05364206658224645,0.14918972880576709,-0.1845419544465094,0.028503071842059538,84,12,96,1,log_other_mut_burden,False,93,-0.1940130907485194,-0.2642697322225928,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02093355317288309,0.061293514096135,0.7334753619812884,-0.1007832183268531,0.1426503246726193,84,12,96,1,log_other_mut_burden,False,93,-0.038059371610826676,0.00164830975372974,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06146563987406009,0.050969563877146566,0.23090421501304464,-0.16268109229771308,0.039749812549592894,84,12,96,1,log_other_mut_burden,False,93,-0.5647761122042745,-0.627846732674855,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07959339104921503,0.05857382576164863,0.17747878000233863,-0.19590940051987302,0.03672261842144295,84,12,96,1,log_other_mut_burden,False,93,-0.49459857439678356,-0.5732251434242214,0.7937051017794727,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07239616816697028,0.06539712716733301,0.2711388493133287,-0.2022619019488647,0.05746956561492414,84,12,96,1,log_other_mut_burden,False,93,-0.04525488091590166,-0.10114118000792778,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007181029739035533,0.057437856865458915,0.9007755190466524,-0.12124123011459956,0.10687917063652849,84,12,96,1,log_other_mut_burden,False,93,-0.09041279552041476,-0.0851697319924195,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0891390848219129,0.06272621760890638,0.15863744871310706,-0.21370092155673015,0.035422751912904324,84,12,96,1,log_other_mut_burden,False,93,-0.3943500552009169,-0.48023761636582635,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0699578101584046,0.05701066460736299,0.22288217481764452,-0.18316969137276723,0.043254071055958035,84,12,96,1,log_other_mut_burden,False,93,-0.14441628266144643,-0.2084204348452192,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038526068312722164,0.05014994911402542,0.44430430017610256,-0.13811392825270458,0.061061791627260234,84,12,96,1,log_other_mut_burden,False,93,-0.05493847922673524,-0.09628790348822018,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08322735525638046,0.04924582406405302,0.09437004401739779,-0.18101980203173215,0.01456509151897123,84,12,96,1,log_other_mut_burden,False,93,-0.31480675364303207,-0.3983424561549462,0.6712449905108455,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06260523539340118,0.042111064099744314,0.14048460025357715,-0.1462294628867067,0.02101899209990435,84,12,96,1,log_other_mut_burden,False,93,-0.42409737785770363,-0.4894988037048036,0.7568502146876953,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08933684812793852,0.0579923781311112,0.12683604055249556,-0.2044982178389282,0.025824521583051152,84,12,96,1,log_other_mut_burden,False,93,-0.2495418512184472,-0.3354709629854704,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0625311914471749,0.05366555558833513,0.24691735307663853,-0.16910034910236743,0.04403796620801764,84,12,96,1,log_other_mut_burden,False,93,-0.5186372862422702,-0.576866199002649,0.8552269457897888,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07636798195428776,0.048602012609278204,0.11951087553996839,-0.17288194677465102,0.020145982866075482,84,12,96,1,log_other_mut_burden,False,93,-0.2709831194196774,-0.3476664587450247,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07030614295032495,0.0480141462106896,0.14648971274910155,-0.165652721609778,0.025040435709128103,84,12,96,1,log_other_mut_burden,False,93,-0.42333781377648755,-0.4936553276219838,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04032455555043189,0.038575846437580205,0.29857911518885666,-0.11692854139610454,0.03627943029524075,84,12,96,1,log_other_mut_burden,False,93,-0.024629920647223094,-0.06214884981651137,0.8856954470736713,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06082310422150557,0.031843278439046455,0.05920480015185282,-0.12405754432048326,0.0024113358774721233,84,12,96,1,log_other_mut_burden,False,93,-0.16829972670668253,-0.22448730606053804,0.5675938449340672,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09101626156815934,0.05037420939874721,0.07402695176134311,-0.19104945798842798,0.009016934852109304,84,12,96,1,log_other_mut_burden,False,93,-0.09724314220186178,-0.18750856935186822,0.6242218401318658,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08174886129894987,0.054052795197854886,0.1338257495037453,-0.1890870000733133,0.025589277475413577,84,12,96,1,log_other_mut_burden,False,93,-0.19060340246300414,-0.2660937210604217,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09971409222515877,0.09201239015311385,0.28129813546886895,-0.28243246353350804,0.08300427908319048,84,12,96,1,log_other_mut_burden,False,93,-0.26851913735600264,-0.35931772848866766,0.8768618853741261,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12575007327139298,0.06952061668918937,0.07371080471581604,-0.012304093484439782,0.26380424002722574,84,12,96,1,log_other_mut_burden,False,93,-0.14516801689018044,-0.0024962090759605058,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07493177554257649,0.0576746364997948,0.1970817119501635,-0.18946217334560483,0.03959862226045187,84,12,96,1,log_other_mut_burden,False,93,-0.3674298820033541,-0.4489573355742124,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05908390500496843,0.04655618164170059,0.20757656165151422,-0.15153525497807116,0.03336744496813431,84,12,96,1,log_other_mut_burden,False,93,-0.07801911297633611,-0.1264830498904971,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08169667040696646,0.05350273935850437,0.13016433147474454,-0.18794250729755613,0.024549166483623222,84,12,96,1,log_other_mut_burden,False,93,-0.33942066168108487,-0.4151196814684279,0.7333906673033306,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06349150279898866,0.04942348087860245,0.2021078792235189,-0.1616367407990035,0.03465373520102619,84,12,96,1,log_other_mut_burden,False,93,-0.129180462158808,-0.18218115119561076,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08609227878567347,0.05322614837228596,0.10916149754257626,-0.19178886079399893,0.019604303222651984,84,12,96,1,log_other_mut_burden,False,93,-0.1460985700247842,-0.22403844151570465,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08284847674457654,0.05304392110436876,0.12171181980288268,-0.18818319151364873,0.022486238024495647,84,12,96,1,log_other_mut_burden,False,93,-0.12358679394567565,-0.19351842891815504,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10398423972176314,0.06356385824986925,0.10524021105936186,-0.2302094647611742,0.02224098531764794,84,12,96,1,log_other_mut_burden,False,93,-0.3242309194699928,-0.4220490904784917,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05663065059641311,0.06236482286885272,0.3661965510922317,-0.06721352780791051,0.18047482900073675,84,12,96,1,log_other_mut_burden,False,93,-0.03606159025551585,0.045697158744477606,0.914684777397777,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04771305342714055,0.07190342799269661,0.5086063309753177,-0.19049901119272175,0.09507290433844065,84,12,96,1,log_other_mut_burden,False,93,-0.26169737485787675,-0.28890175418949066,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1308222421408441,0.07623835271815209,0.08949824206845103,-0.020572017009599153,0.28221650129128734,84,12,96,1,log_other_mut_burden,False,93,0.000552020077742188,0.16200545948736458,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10069908791902772,0.09053411561113141,0.2688856815114159,-0.280481898959807,0.07908372312175156,84,12,96,1,log_other_mut_burden,False,93,-0.3044493193850772,-0.39283232658900236,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02197750596140726,0.05366896103918474,0.6831135082882057,-0.0845984142442611,0.12855342616707563,84,12,96,1,log_other_mut_burden,False,93,-0.08015546902811613,-0.03561790950085488,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06873750338035843,0.05186120622806848,0.1882811370478481,-0.17172358080221972,0.034248574041502874,84,12,96,1,log_other_mut_burden,False,93,-0.3110519699353331,-0.3798967315939685,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12550824450633205,0.05297829937368722,0.019901758571752148,-0.23071264752355633,-0.02030384148910777,84,12,96,1,log_other_mut_burden,False,93,-0.44957520924960503,-0.5704927343930098,0.32372983512821424,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030952497114751176,0.0420406855295782,0.4634310279933068,-0.11443696671572977,0.052531972486227416,84,12,96,1,log_other_mut_burden,False,93,-0.1690777005717708,-0.19651960306200297,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05285200710528497,0.04972439058780668,0.29057994461926323,-0.15159479215179184,0.045890777941221914,84,12,96,1,log_other_mut_burden,False,93,-0.23841316250417482,-0.27969442860794574,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10846706895294089,0.08533962885525626,0.20689694163558928,-0.061000520863426166,0.27793465876930795,84,12,96,1,log_other_mut_burden,False,93,-0.10287677030150995,0.026417086469345777,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08860307824482089,0.06090749917999291,0.14911500466024163,-0.20955330062371758,0.032347144134075786,84,12,96,1,log_other_mut_burden,False,93,-0.06052071952903334,-0.15070069203612077,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09848180603636444,0.0411991779337819,0.01884666897206492,-0.18029520832682494,-0.016668403745903934,84,12,96,1,log_other_mut_burden,False,93,-0.14291136769024898,-0.24206330607996676,0.3146632024742357,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04088125289166887,0.06805690802314199,0.5495061793552002,-0.17602878432279107,0.09426627853945331,84,12,96,1,log_other_mut_burden,False,93,-0.06576266570079042,-0.10049217391622367,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06171583198575997,0.05172748755877472,0.23586690128958987,-0.16443637063152583,0.04100470666000587,84,12,96,1,log_other_mut_burden,False,93,-0.0956665373369672,-0.15420740486174186,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037621775593154605,0.06530720928345252,0.565956778953226,-0.167308950278097,0.09206539909178779,84,12,96,1,log_other_mut_burden,False,93,-0.15651760492732253,-0.19402481297820892,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07296489537176844,0.03602394895633782,0.045686611985499746,-0.14450131856916543,-0.0014284721743714618,84,12,96,1,log_other_mut_burden,False,93,-0.2610711149882552,-0.32929094177201407,0.5122320987865776,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10504243354740685,0.04856607761393223,0.0331152727112229,-0.20148503858881356,-0.008599828506000148,84,12,96,1,log_other_mut_burden,False,93,-0.09199926838962814,-0.1910162313744113,0.43476822754237954,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00907537224963317,0.07377463189748443,0.902360827649688,-0.13742642562508667,0.15557717012435301,84,12,96,1,log_other_mut_burden,False,93,-0.04449513131265939,-0.019854136638506364,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00400799239833554,0.06601078219548838,0.951714693442554,-0.13509232344852334,0.12707633865185225,84,12,96,1,log_other_mut_burden,False,93,-0.09652576586750863,-0.08861092526400305,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002558884787906293,0.04109044823310059,0.9504779251691743,-0.08415637144148058,0.079038601865668,84,12,96,1,log_other_mut_burden,False,93,-0.13573057410253916,-0.14006857876888226,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04399844757789569,0.09154031110095108,0.6318971704070244,-0.22577936344794547,0.13778246829215407,84,12,96,1,log_other_mut_burden,False,93,-0.08678173712139911,-0.11173237304536521,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08249587303643693,0.06720128263077228,0.22269770694357566,-0.215944302010991,0.05095255593811712,84,12,96,1,log_other_mut_burden,False,93,-0.23479780172390025,-0.30841749205348984,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10193812752666129,0.057262025566209795,0.07830836237674411,-0.2156491617891576,0.011772906735835045,84,12,96,1,log_other_mut_burden,False,93,-0.38464451793903204,-0.47992945271782395,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07468379302767499,0.09005150083380437,0.40903267289918643,-0.2535082267680081,0.10414064071265815,84,12,96,1,log_other_mut_burden,False,93,-0.0867856704096999,-0.1512783421999346,0.9256023179739352,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07052002094033247,0.050560712002934105,0.1664109736622526,-0.17092357457037566,0.029883532689710723,84,12,96,1,log_other_mut_burden,False,93,-0.23696084499375747,-0.2947514612283803,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04163448219911804,0.07567634343960931,0.583525125014223,-0.19191270230455187,0.10864373790631578,84,12,96,1,log_other_mut_burden,False,93,-0.17640227981373607,-0.20252732660673647,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017930408425813914,0.0686329794693715,0.7944769213114352,-0.11836108672842363,0.15422190358005147,84,12,96,1,log_other_mut_burden,False,93,-0.1168804172466067,-0.08380985873612619,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058241246275968564,0.07764043926757429,0.4550636263252208,-0.09593727888818716,0.2124197714401243,84,12,96,1,log_other_mut_burden,False,93,0.0010235034586560626,0.08197005482269533,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15480006040758543,0.06919786368771574,0.027671311265944954,-0.2922133036675063,-0.017386817147664546,84,12,96,1,log_other_mut_burden,False,93,-0.14786563218101711,-0.3000458336087054,0.3929425202666745,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07294957038087913,0.038337446009411316,0.06015650016644444,-0.14908014022375315,0.0031809994619949183,84,12,96,1,log_other_mut_burden,False,93,-0.490134052263612,-0.5717798435378952,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009318249773278262,0.05714297072574718,0.870817896132901,-0.10415636517102075,0.12279286471757728,84,12,96,1,log_other_mut_burden,False,93,-0.06829090362330897,-0.047403607009742055,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04004587820254561,0.05486494863427761,0.4672863844323596,-0.14899679274448452,0.06890503633939328,84,12,96,1,log_other_mut_burden,False,93,-0.04837626835781109,-0.0775993160417892,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13944907186356756,0.06613490134378762,0.03767124962135071,-0.2707798789436431,-0.008118264783492063,84,12,96,1,log_other_mut_burden,False,93,-0.37586237464585015,-0.517872886961284,0.46506124338146493,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00675483443689294,0.04500026988114339,0.8810056389952456,-0.0961164520129192,0.08260678313913332,84,12,96,1,log_other_mut_burden,False,93,-0.1709601678857523,-0.17075109857709506,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1570376876798249,0.06240920411039547,0.013574358219767246,-0.28096999843412707,-0.03310537692552275,84,12,96,1,log_other_mut_burden,False,93,-0.23696552297277124,-0.3893608758597902,0.2505889663918893,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1581703802244789,0.06740713029590588,0.02107407081959824,-0.29202758186593414,-0.024313178583023703,84,12,96,1,log_other_mut_burden,False,93,-0.33420481509091776,-0.4915221726482594,0.33504311408065957,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020675670891391894,0.047923257569213756,0.6671520931828042,-0.11584176272169878,0.07449042093891499,84,12,96,1,log_other_mut_burden,False,93,-0.007988015207734057,-0.020969325210221056,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0943986134958485,0.05975054781682954,0.11753001007324648,-0.21305135975866546,0.024254132766968486,84,12,96,1,log_other_mut_burden,False,93,-0.010369762037906663,-0.10296644061689288,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03431464038670455,0.05023814232586868,0.4962798873141161,-0.1340776345667783,0.06544835379336918,84,12,96,1,log_other_mut_burden,False,93,-0.1436730866162772,-0.17468470314777107,0.9429080290807693,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08546862226298002,0.05291921013113237,0.1096816741194757,-0.19055568575513054,0.019618441229170516,84,12,96,1,log_other_mut_burden,False,93,-0.28411283325932135,-0.3580617035407963,0.6987504796661628,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060212742851956644,0.10764964502526418,0.5772743331482839,-0.2739836032568101,0.15355811755289683,84,12,96,1,log_other_mut_burden,False,93,-0.149867548257908,-0.1911034267160943,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09390933465293651,0.06390087163164367,0.14504241147397623,-0.22080380147733403,0.032985132171461026,84,12,96,1,log_other_mut_burden,False,93,-0.3440756689559399,-0.4261382063188579,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1096878931691021,0.06961920932766237,0.11852752089903347,-0.2479378453652957,0.028562059027091496,84,12,96,1,log_other_mut_burden,False,93,-0.15335497155322284,-0.24466177474183878,0.7204222518350135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03936508725830254,0.0985740719222516,0.6905544295596326,-0.23511365812896542,0.15638348361236035,84,12,96,1,log_other_mut_burden,False,93,-0.27326347538839896,-0.2972723050395879,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014774483243219769,0.04721621112705465,0.7550487242553324,-0.10853652096586035,0.07898755447942081,84,12,96,1,log_other_mut_burden,False,93,-0.1887848400736001,-0.19639504065617444,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0667183107473554,0.0676255843924879,0.32640653037963197,-0.20100931893015447,0.06757269743544367,84,12,96,1,log_other_mut_burden,False,93,-0.5988886058276313,-0.6521102505153485,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07159396672518512,0.0883100161272297,0.41960105551760163,-0.2469601569755468,0.10377222352517657,84,12,96,1,log_other_mut_burden,False,93,0.03681861463624263,-0.012940972970022445,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028766297946334243,0.04029643610864641,0.47709717644698657,-0.10878703388255484,0.05125443798988635,84,12,96,1,log_other_mut_burden,False,93,-0.1303682222275707,-0.1527242064445469,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06004262659563538,0.041552792898652144,0.15182679584890899,-0.14255823812491505,0.022472984933644295,84,12,96,1,log_other_mut_burden,False,93,-0.10620694835953867,-0.16243013973672366,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07133151175006665,0.045077459155384164,0.11694854851650802,-0.16084641192692828,0.01818338842679497,84,12,96,1,log_other_mut_burden,False,93,-0.20619760762730047,-0.27206480565777796,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07573944430041796,0.03307921432582055,0.02430418572623027,-0.14142820812576676,-0.010050680475069157,84,12,96,1,log_other_mut_burden,False,93,-0.13842008248749366,-0.20842001438392352,0.36818058453209135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06687743662878498,0.05839671291348659,0.2550541346111913,-0.1828417350842188,0.049086861826648856,84,12,96,1,log_other_mut_burden,False,93,-0.25210645891038136,-0.31167959246804083,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05333721442887452,0.03791867588541568,0.16287261424059735,-0.1286361897997242,0.021961760941975154,84,12,96,1,log_other_mut_burden,False,93,-0.1213903380095405,-0.16968880893515534,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06803282289972035,0.03906522051766527,0.08489924519960451,-0.14560860868151973,0.009542962882079037,84,12,96,1,log_other_mut_burden,False,93,-0.17639704634051917,-0.23845508954751082,0.652400976180504,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06753546233989736,0.04587828997235265,0.1443815420527001,-0.15864065380607906,0.023569729126284328,84,12,96,1,log_other_mut_burden,False,93,-0.0824283947212017,-0.14421383170284707,0.7635967032883216,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059954829223249094,0.03985758784227903,0.13591172459709988,-0.13910409947589483,0.019194441029396637,84,12,96,1,log_other_mut_burden,False,93,-0.11580486096955347,-0.17233153288414957,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10053233461743541,0.056286782516373,0.07734646188817497,-0.2123067294621377,0.01124206022726687,84,12,96,1,log_other_mut_burden,False,93,-0.06413341096528663,-0.1620996489363864,0.6316627720867622,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07940506693840499,0.03467932618447687,0.02430079574016432,-0.14827133579582977,-0.01053879808098021,84,12,96,1,log_other_mut_burden,False,93,-0.1569417752279394,-0.2368382743052088,0.36818058453209135,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07521735741214466,0.036254468151068975,0.040776312119570855,-0.14721154604468029,-0.0032231687796090286,84,12,96,1,log_other_mut_burden,False,93,-0.07602391967544254,-0.14907466585609244,0.4874734421764359,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10347571051803972,0.04927399723756588,0.038435486895936746,-0.2013241036324691,-0.0056273174036103185,84,12,96,1,log_other_mut_burden,False,93,-0.20292943820712084,-0.3043104100134367,0.4724959974258181,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03902746650231479,0.04073848685824118,0.3405466891859984,-0.11992602761911361,0.041871094614484024,84,12,96,1,log_other_mut_burden,False,93,-0.13255411989012086,-0.16610874324925642,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045426931221775255,0.049591720265615404,0.36202639692487615,-0.14390625930176487,0.05305239685821435,84,12,96,1,log_other_mut_burden,False,93,-0.02386269607729779,-0.06941503058077662,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08294303640432253,0.04875956297280957,0.09227279857124356,-0.1797698650224372,0.013883792213792143,84,12,96,1,log_other_mut_burden,False,93,-0.08027111761629342,-0.1581442970380942,0.6674195391201606,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055186941290723004,0.03236023355497324,0.09145910359080872,-0.11944795179684346,0.009074069215397454,84,12,96,1,log_other_mut_burden,False,93,-0.11680510656823843,-0.1681187552812339,0.6648373299485711,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09819356889642328,0.044168645392944655,0.028628128668215465,-0.18590374505493007,-0.010483392737916486,84,12,96,1,log_other_mut_burden,False,93,-0.10761100625328442,-0.2000113322545325,0.4029256832771177,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07364389088560984,0.03663249097162571,0.04729132312409577,-0.14638875792107114,-0.0008990238501485198,84,12,96,1,log_other_mut_burden,False,93,0.024349808190608262,-0.03877543312062609,0.5160635391563032,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08859170214852863,0.04394876999169316,0.04670698219867746,-0.17586524933630016,-0.001318154960757087,84,12,96,1,log_other_mut_burden,False,93,-0.34865164915103036,-0.4308060568324407,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:896,TP53,CCND3,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10918244178897363,0.05104580940441374,0.035062629735076956,-0.2105493027190095,-0.007815580858937729,84,12,96,1,log_other_mut_burden,False,93,-0.26168448369757347,-0.3693180623682233,0.4493241481738629,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19203913535854056,0.2079088848548036,0.359485174568031,-0.6082139852815396,0.2241357145644584,54,7,61,1,log_other_mut_burden,False,58,0.06664753867390541,-0.030399900623994065,0.9133814160475374,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02016225948578652,0.21542292789812484,0.9257543703062419,-0.4513781007452215,0.4110535817736484,54,7,61,1,log_other_mut_burden,False,58,-0.08739281915141842,0.0332366725440871,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.102241371250394,0.1432964406688873,0.47840042098978364,-0.38908036195308615,0.18459761945229813,54,7,61,1,log_other_mut_burden,False,58,-0.0309014818879966,-0.028720532375186496,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004454261880410326,0.2352522808844856,0.9849587578188365,-0.47536286571193115,0.4664543419511105,54,7,61,1,log_other_mut_burden,False,58,-0.021779804805597994,0.19789242630499398,0.998871063691614,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04611662689019251,0.13695953235937458,0.7375454530665191,-0.3202709174343078,0.22803766365392275,54,7,61,1,log_other_mut_burden,False,58,0.034523461553496435,0.1244131124091071,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1271632186597923,0.11775050956550075,0.2846402935580157,-0.36286647242406594,0.10854003510448135,54,7,61,1,log_other_mut_burden,False,58,-0.023965752378989617,-0.036400934298445924,0.877125252431494,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14809869912660184,0.18524973419173793,0.4272890435964205,-0.5189163309914611,0.22271893273825744,54,7,61,1,log_other_mut_burden,False,58,-0.06290457978128759,0.008678685791033813,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10615211614023692,0.12469927695563063,0.3981232342838278,-0.3557648390825918,0.14346060680211797,54,7,61,1,log_other_mut_burden,False,58,0.05518760901200213,0.014636608485233469,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07750735371411877,0.11828392195330946,0.5148875855123979,-0.3142783483813288,0.15926364095309126,54,7,61,1,log_other_mut_burden,False,58,-0.010920792004324189,-0.00011970919412897439,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06698543274866882,0.18062240187307832,0.7120937231084302,-0.42854045260631685,0.29456958710897924,54,7,61,1,log_other_mut_burden,False,58,-0.06170024629751237,0.09908573600968915,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06562518142750752,0.1472709114815559,0.6575389357459035,-0.3604199398461433,0.22916957699112828,54,7,61,1,log_other_mut_burden,False,58,0.06014237260974397,0.10490311022630298,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039831337380269734,0.19343391233519838,0.8375768049212418,-0.4270313817282531,0.34736870696771366,54,7,61,1,log_other_mut_burden,False,58,-0.07007293265840926,0.09544741891615405,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08587363600197993,0.15078072689797356,0.57119811223208,-0.38769405330578144,0.21594678130182154,54,7,61,1,log_other_mut_burden,False,58,0.01445195704535277,0.05962156314618602,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06123311370965825,0.12324382136528468,0.6211762189979428,-0.30793242574942076,0.18546619833010425,54,7,61,1,log_other_mut_burden,False,58,-0.021298045131773375,0.020666954795237193,0.9582992440631078,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07119196087180608,0.20346453990675956,0.7276821953600877,-0.4784704878067327,0.33608656606312054,54,7,61,1,log_other_mut_burden,False,58,-0.14288755269804299,-0.17746241661256343,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11420706563673023,0.14535664260412529,0.4352399400455371,-0.40516999857405805,0.1767558673005976,54,7,61,1,log_other_mut_burden,False,58,-0.08002087551418569,-0.25927076038392055,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04426974057925041,0.1064770686045919,0.6791142131750143,-0.25740675046559375,0.16886726930709295,54,7,61,1,log_other_mut_burden,False,58,-0.07151960834950867,-0.04453782595540586,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10044265323660477,0.15972627587246563,0.5319211499913115,-0.42016953232792453,0.21928422585471496,54,7,61,1,log_other_mut_burden,False,58,0.07041854068194872,0.1231005223012425,0.9463401736865253,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043480806918737916,0.14281813780980596,0.7618757229869417,-0.3293623704256902,0.24240075658821442,54,7,61,1,log_other_mut_burden,False,58,0.01731405431158284,0.09000373900160243,0.9681057644104086,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06965340091204208,0.12060408053719798,0.5658116505253876,-0.3110686975826114,0.17176189575852724,54,7,61,1,log_other_mut_burden,False,58,0.03201343010606295,0.08974732340572654,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16204493313048618,0.15266856824074732,0.2929005087796838,-0.4676442754574101,0.14355440919643775,54,7,61,1,log_other_mut_burden,False,58,-0.11027400619912399,-0.04765579013907043,0.8803348634474737,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04984686640836519,0.22355160486446018,0.824336832209683,-0.49733402247428227,0.3976402896575518,54,7,61,1,log_other_mut_burden,False,58,-0.0027137628094999863,0.0932632816887453,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05647858856067384,0.12519622075484696,0.6535848507620672,-0.3070860525945576,0.19412887547320995,54,7,61,1,log_other_mut_burden,False,58,-0.09256474378066469,-0.052514236173289416,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03209483430662678,0.2013631874309157,0.8739171028186863,-0.3709773786370513,0.4351670472503049,54,7,61,1,log_other_mut_burden,False,58,-0.06429830567009556,0.12316248384098627,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0011384764071899224,0.12872947826841596,0.9929739948751544,-0.25881852378197234,0.25654157096759245,54,7,61,1,log_other_mut_burden,False,58,-0.0381108193467833,0.1026876732767396,0.999521629637202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10178504496038498,0.14089548620607872,0.4729420920996973,-0.38381800313623665,0.18024791321546668,54,7,61,1,log_other_mut_burden,False,58,0.1210812590621317,0.14008766388636637,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011400197603475042,0.12264348132271113,0.9262604799108602,-0.25689779848358557,0.23409740327663547,54,7,61,1,log_other_mut_burden,False,58,-0.11236921688973289,-0.029018021336309374,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07980180711035952,0.13767849083754505,0.5644127339350187,-0.3553952494106031,0.19579163518988407,54,7,61,1,log_other_mut_burden,False,58,0.2303804758054061,0.2344602646045668,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07848807480983631,0.1184739726941315,0.5102799604398492,-0.31563949736782454,0.15866334774815194,54,7,61,1,log_other_mut_burden,False,58,-0.05645092456750643,-0.016155754623552867,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006419699543836458,0.123572885956672,0.9587464783752404,-0.25377770592959203,0.24093830684191914,54,7,61,1,log_other_mut_burden,False,58,0.1140563079454255,0.21546283038916042,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04682911420051389,0.13288723854519388,0.7258175996978439,-0.31283182301620716,0.21917359461517938,54,7,61,1,log_other_mut_burden,False,58,-0.046314966220100916,-0.005099777425187413,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15663234800820347,0.1913356950141873,0.4163507502506101,-0.5396323540591825,0.22636765804277564,54,7,61,1,log_other_mut_burden,False,58,-0.13922353878075994,-0.06908149790921465,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09293425592254301,0.20334377415092506,0.6493565175139693,-0.4999710439325297,0.3141025320874437,54,7,61,1,log_other_mut_burden,False,58,-0.06762857862027881,0.021882803572504796,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11436366526996404,0.11890040335137247,0.34012083011892835,-0.3523686815303271,0.12364135099039901,54,7,61,1,log_other_mut_burden,False,58,-0.004476262121890241,-0.0069782865087853795,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09668075909780895,0.15277146511222767,0.5293217295120725,-0.4024860718914389,0.20912455369582106,54,7,61,1,log_other_mut_burden,False,58,-0.12049573819985057,-0.07749792741028357,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12006321583013672,0.18177279195473373,0.5115398694456964,-0.24379455996754817,0.48392099162782165,54,7,61,1,log_other_mut_burden,False,58,0.290872045606867,0.3529213663274069,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13061985143629276,0.12856841578157666,0.3138697752870611,-0.387977497215129,0.12673779434254348,54,7,61,1,log_other_mut_burden,False,58,0.004651247629367223,-0.022603115903761812,0.901410374901842,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1448461835108607,0.17498778160726813,0.4112049158545569,-0.205429918444196,0.4951222854659174,54,7,61,1,log_other_mut_burden,False,58,0.46680199409504797,0.4819410092869531,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040066031574381746,0.11179096031868614,0.7213442116402997,-0.26383995141368205,0.18370788826491855,54,7,61,1,log_other_mut_burden,False,58,-0.06572914466764677,-0.030206674354382908,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025307550107099067,0.10333780836493554,0.8073973600533932,-0.23216064788444032,0.1815455476702422,54,7,61,1,log_other_mut_burden,False,58,0.014098660922649522,0.06953554400282404,0.9744449538485335,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05761391548957275,0.10335701492352285,0.5793812699894381,-0.26450545937104847,0.14927762839190298,54,7,61,1,log_other_mut_burden,False,58,-0.06795369542396397,0.007816296691606153,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056646065193473094,0.1189901330975872,0.6358222760561991,-0.29483069505568205,0.18153856466873589,54,7,61,1,log_other_mut_burden,False,58,-0.010330879049690826,-0.004957319164293277,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06591273790141908,0.1106511911608047,0.5537062620853654,-0.2874051618894986,0.15557968608666045,54,7,61,1,log_other_mut_burden,False,58,-0.008854923493717514,0.00426555576850434,0.9486985340888475,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03919468276164328,0.11145628815332224,0.7263679009657246,-0.26229868347607793,0.18390931795279136,54,7,61,1,log_other_mut_burden,False,58,-0.011920167387804213,0.03675706244052089,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0760139923507934,0.0951020422663656,0.4273842488252072,-0.2663814131332966,0.11435342843170981,54,7,61,1,log_other_mut_burden,False,58,0.04947483354456029,0.037573285232218916,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09366311667111789,0.09605227887112694,0.33354715245406386,-0.2859326426794467,0.09860640933721092,54,7,61,1,log_other_mut_burden,False,58,-0.027989857403247196,-0.04124252430647696,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04013020722594185,0.0939844667226714,0.6709692181065199,-0.22826055750277927,0.14800014305089557,54,7,61,1,log_other_mut_burden,False,58,-0.05047835772732388,0.032218345778548985,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07757865231025636,0.09691181008335874,0.42668359760748575,-0.2715687169742781,0.11641141235376538,54,7,61,1,log_other_mut_burden,False,58,-0.020736905820930795,-0.05449933777659842,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03216448999958352,0.08611751605611183,0.7101415563133172,-0.20454742758026062,0.14021844758109359,54,7,61,1,log_other_mut_burden,False,58,0.03570278651957764,-0.01102314421028843,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07865660954229545,0.12198938533676906,0.5216104538978901,-0.32284489505103653,0.16553167596644563,54,7,61,1,log_other_mut_burden,False,58,-0.02230123765447694,0.008666555282972737,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045912989657302256,0.1065213418802519,0.6680504570817547,-0.2591386221336146,0.16731264281901012,54,7,61,1,log_other_mut_burden,False,58,-0.269215174823168,-0.29065404192350347,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1081587380301106,0.11139139278468074,0.3355905714500572,-0.33113283655049547,0.11481536049027428,54,7,61,1,log_other_mut_burden,False,58,0.2911466248398007,0.23788333480274584,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17274669396015166,0.2455481357147838,0.4845498362761661,-0.6642646904197016,0.3187713024993982,54,7,61,1,log_other_mut_burden,False,58,-0.15174406440952803,-0.12367137148312084,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014619304539558115,0.15447034014045613,0.9249257973843024,-0.3238252851805708,0.29458667610145456,54,7,61,1,log_other_mut_burden,False,58,0.2479776631390223,0.28667583359641075,0.9915432628301946,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1571807333968363,0.15406370002971395,0.3118552018517596,-0.4655727354184216,0.15121126862474898,54,7,61,1,log_other_mut_burden,False,58,0.07425299659782414,0.03642899314603102,0.8990379896110621,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0997979349859922,0.1543685602415251,0.5205113450429832,-0.20920431105179566,0.4088001810237801,54,7,61,1,log_other_mut_burden,False,58,-0.05188724410014737,0.2207383961075837,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1559420637694633,0.16092469713862084,0.3365502078636595,-0.4780678436626174,0.16618371612369082,54,7,61,1,log_other_mut_burden,False,58,-0.07596206436385698,-0.14376303454425007,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05778646651446129,0.19734428040476973,0.77070436062991,-0.3372410299678263,0.45281396299674886,54,7,61,1,log_other_mut_burden,False,58,0.09765454007473183,0.3429186955162953,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0921378391186007,0.14207789179881655,0.5192195363995038,-0.37653763924278677,0.1922619610055854,54,7,61,1,log_other_mut_burden,False,58,-0.0709857096887222,-0.04105411840881912,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03899963522065597,0.09905456661160146,0.69523245485417,-0.15927962265021556,0.2372788930915275,54,7,61,1,log_other_mut_burden,False,58,-0.04900019426070754,0.11225158434796724,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0732441465961862,0.09615327093934498,0.4492994454179545,-0.26571583019322703,0.11922753700085464,54,7,61,1,log_other_mut_burden,False,58,0.028781576724320888,-0.03209196236729351,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028088572647969524,0.12569797168842362,0.8239620702639152,-0.2797004002982799,0.22352325500234085,54,7,61,1,log_other_mut_burden,False,58,-0.11901117459392069,-0.04635742563565289,0.9798720835700006,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06388454144515478,0.15107239045113424,0.6739511908742457,-0.3662887867828059,0.23851970389249638,54,7,61,1,log_other_mut_burden,False,58,-0.08619866742155465,-0.03110885785086425,0.9604420702583071,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05416756890175084,0.19400015343497867,0.781073791426838,-0.442501067959406,0.33416593015590434,54,7,61,1,log_other_mut_burden,False,58,-0.0041872966798962635,0.14836015808421163,0.971527114099096,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12675510405283502,0.14600655978650792,0.38889206819413413,-0.4190189875773846,0.16550877947171455,54,7,61,1,log_other_mut_burden,False,58,-0.009278997949748307,-0.04877947063638539,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05969814867201386,0.12383271187486901,0.6315583908109261,-0.3075762531410585,0.18817995579703078,54,7,61,1,log_other_mut_burden,False,58,0.003988135723861514,0.05850253409244642,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10844244445121731,0.13076076492807398,0.4103238801192002,-0.37018855384794813,0.1533036649455135,54,7,61,1,log_other_mut_burden,False,58,-0.037172089249163764,0.015412931921354987,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09455104076651123,0.1640032770802354,0.5664950519454217,-0.42283926795513405,0.2337371864221116,54,7,61,1,log_other_mut_burden,False,58,0.1692859758157401,0.12610757413281962,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025590866622868275,0.1260538309080662,0.8398335471059217,-0.27791502389503153,0.22673329064929496,54,7,61,1,log_other_mut_burden,False,58,-0.028335576848531496,0.04518177098981764,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10863746387297883,0.12515159656574357,0.38894617435464385,-0.35915560288731857,0.14188067514136088,54,7,61,1,log_other_mut_burden,False,58,0.029455643413579074,-0.010739789018329568,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08222512304372852,0.09041615864409278,0.3668987911175752,-0.26321272865085843,0.09876248256340138,54,7,61,1,log_other_mut_burden,False,58,0.08427316580557766,0.08111286685251831,0.9150244079451123,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02578564502334606,0.09524250427174158,0.7875546741300847,-0.2164342310578685,0.16486294101117635,54,7,61,1,log_other_mut_burden,False,58,0.08514245211462373,0.10858926701327268,0.9725589613012776,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11047223102740748,0.10421711941844274,0.2935299429293996,-0.31908546111455627,0.09814099905974129,54,7,61,1,log_other_mut_burden,False,58,0.005735104869600451,-0.041697760198512124,0.8803348634474737,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05818490615410054,0.2127454013066318,0.7854439404954211,-0.4840410956210801,0.367671283312879,54,7,61,1,log_other_mut_burden,False,58,-0.09706960547560597,0.04787469915620484,0.9722536916492144,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13468665439862343,0.0995653718048807,0.18138694340154818,-0.3339883999558742,0.06461509115862735,54,7,61,1,log_other_mut_burden,False,58,0.010766174838298606,-0.052756683849889977,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029221221199209082,0.1448298554912155,0.8408084547610958,-0.319129675162203,0.26068723276378486,54,7,61,1,log_other_mut_burden,False,58,-0.053246944687500956,0.07509971320176152,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10899626168963975,0.1098588608081097,0.3252465038755894,-0.32890266415751074,0.11091014077823125,54,7,61,1,log_other_mut_burden,False,58,-0.009269804730769682,-0.05244081966885909,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021988756745833414,0.1009315452729355,0.8283043187995857,-0.22402519562046483,0.180047682128798,54,7,61,1,log_other_mut_burden,False,58,0.034486889520176554,0.12341276470487332,0.9817239773275311,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047686391843463925,0.117695541287455,0.6868450997693947,-0.2832796146445001,0.1879068309575722,54,7,61,1,log_other_mut_burden,False,58,-0.06319360382333067,-0.042238636216864515,0.9631430579652833,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05497812402303645,0.11396342306626248,0.6313240269893339,-0.2831007005278145,0.1731444524817416,54,7,61,1,log_other_mut_burden,False,58,0.007135587539439309,0.023200588867990615,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06361436314781153,0.11336314949075793,0.5768532236403769,-0.2905353615412318,0.16330663524560868,54,7,61,1,log_other_mut_burden,False,58,0.010846705631764231,0.06817208365710334,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05362542998198498,0.06780326874547446,0.4322261156516738,-0.1893484185119994,0.08209755854802943,54,7,61,1,log_other_mut_burden,False,58,-0.09194200907460787,-0.13869784071983468,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06214683421353641,0.11794597730969916,0.6002661277267658,-0.29824135917895844,0.17394769075188565,54,7,61,1,log_other_mut_burden,False,58,-0.000251898068870366,0.04312721549039857,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014875984246664921,0.06558971226372262,0.8213739359481637,-0.14616805806501368,0.11641608957168384,54,7,61,1,log_other_mut_burden,False,58,-0.047582918749624524,-0.044762742243197914,0.9793038292216457,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09507437612640866,0.11005221683227982,0.3912001972410799,-0.31536782272852576,0.12521907047570846,54,7,61,1,log_other_mut_burden,False,58,-0.03244745957923851,0.024123862400346346,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06241441799878359,0.10838971652090157,0.5669554776566179,-0.27938000866021795,0.15455117266265078,54,7,61,1,log_other_mut_burden,False,58,0.1151070812195045,0.14858293494296101,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10655026795948667,0.13289224428589694,0.42595336745607004,-0.3725629968538664,0.15946246093489302,54,7,61,1,log_other_mut_burden,False,58,-0.09278021509560937,-0.037329502111871964,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08362198191851396,0.15131282663916049,0.5826315447097564,-0.38650751257755844,0.21926354874053056,54,7,61,1,log_other_mut_burden,False,58,0.03744379717012095,0.14616062677667813,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009857680933870211,0.13888916472925492,0.9436616904793231,-0.2878745503307476,0.2681591884630071,54,7,61,1,log_other_mut_burden,False,58,0.025245251501383178,0.16425457038724062,0.9928146453313277,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1250131961325719,0.1249941107368109,0.3213911279773365,-0.375216093009632,0.1251897007444882,54,7,61,1,log_other_mut_burden,False,58,-0.030518121151489115,-0.11246987174394106,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1282759393792554,0.14030096697744557,0.3643492237248336,-0.40911883802049154,0.15256695926198072,54,7,61,1,log_other_mut_burden,False,58,-0.08644520291667422,-0.03208270821111457,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08928613451522696,0.12544506932098048,0.4794697355849048,-0.34039172307484467,0.16181945404439077,54,7,61,1,log_other_mut_burden,False,58,-0.0064567980267377645,-0.00418380552578747,0.9384017168502401,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08499764246223082,0.15840965604220592,0.5936178963780939,-0.40208902061934737,0.23209373569488576,54,7,61,1,log_other_mut_burden,False,58,-0.00857343050369527,0.062069293996085705,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0132888234039868,0.12670592389238525,0.9168334767859585,-0.2669182866041499,0.24034063979617631,54,7,61,1,log_other_mut_burden,False,58,0.09083666801911511,0.16781939556086972,0.989733344444655,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026561688500250497,0.16110915436600262,0.869621419211343,-0.34905669965053165,0.2959333226500307,54,7,61,1,log_other_mut_burden,False,58,-0.0010487956443671178,0.13720135617369636,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029887802691698297,0.10370528369428356,0.7742215027173435,-0.23747648226078752,0.17770087687739092,54,7,61,1,log_other_mut_burden,False,58,0.22135514019075392,0.20529620692224473,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09767056431684189,0.11677635635580237,0.4063683590572642,-0.33142383856902613,0.13608270993534233,54,7,61,1,log_other_mut_burden,False,58,0.04312436661419446,0.012400400517456287,0.9239663408808872,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045759708565275316,0.1576527504931397,0.772655407620034,-0.3613359756509795,0.26981655852042885,54,7,61,1,log_other_mut_burden,False,58,0.028132248164703527,0.12549113419884697,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07215979479650927,0.13742538114671535,0.6015266926107026,-0.34724658300321243,0.20292699341019385,54,7,61,1,log_other_mut_burden,False,58,0.014921071139362037,0.09368099818676967,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007263006390116354,0.1054048973333976,0.9453016336699083,-0.21825383229691184,0.20372781951667915,54,7,61,1,log_other_mut_burden,False,58,0.07801973139753977,0.09234711002435494,0.993077588787628,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012215193013292583,0.10904454160721026,0.9111941673714412,-0.20606117247246283,0.23049155849904798,54,7,61,1,log_other_mut_burden,False,58,0.0668377393059169,0.11752504405235145,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09487085290412756,0.08588166802766477,0.273864544722739,-0.266781689362661,0.07703998355440589,54,7,61,1,log_other_mut_burden,False,58,-0.027631283660935074,-0.03662672986871653,0.870270919138952,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032947418694448505,0.08384521216141984,0.6957931196335682,-0.13488700845093232,0.20078184583982933,54,7,61,1,log_other_mut_burden,False,58,-0.012589529686032898,0.048278936676820115,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1674432554043209,0.13814075943063217,0.23038093736110946,-0.44396202882971814,0.10907551802107637,54,7,61,1,log_other_mut_burden,False,58,-0.12764435869119262,-0.24078845384500316,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019557415421416792,0.08132840242678605,0.810810321297418,-0.14323906967388064,0.1823539005167142,54,7,61,1,log_other_mut_burden,False,58,0.0033538113559130026,0.08267671307744218,0.9751836864331673,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13809580709574332,0.1612221773708691,0.3952155646759399,-0.46081705837097636,0.18462544417948973,54,7,61,1,log_other_mut_burden,False,58,-0.04523294636316641,-0.1439064642146368,0.920957044807631,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006499861495866165,0.0844666725677745,0.938926741512919,-0.16257855381061878,0.17557827680235114,54,7,61,1,log_other_mut_burden,False,58,0.03025076624403081,0.039098672536931035,0.992787535469879,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15345037172541323,0.15694906345561618,0.33227925216059884,-0.46761805616474017,0.16071731271391373,54,7,61,1,log_other_mut_burden,False,58,-0.08444619248829648,-0.1788033036695338,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0840343121938206,0.07697346100274571,0.27946571210560994,-0.23811343489818815,0.07004481051054695,54,7,61,1,log_other_mut_burden,False,58,-0.06778437841723402,-0.11134520574390547,0.875118556630215,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03328638714412844,0.06871664189635447,0.6299258025678678,-0.1708376906798082,0.10426491639155133,54,7,61,1,log_other_mut_burden,False,58,-0.07348572110165409,-0.10010761252304291,0.96007126858481,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052057271449406174,0.09684257688817023,0.5929475695082513,-0.24590875081613583,0.1417942079173235,54,7,61,1,log_other_mut_burden,False,58,0.04091982638492415,0.04877244261196394,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09751034767043266,0.10616994009273764,0.3621941294500499,-0.3100325730447178,0.1150118777038525,54,7,61,1,log_other_mut_burden,False,58,-0.012265780374209294,0.016844306617350622,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1154705326539964,0.17068050447420882,0.501393191537977,-0.4571246826627493,0.22618361735475653,54,7,61,1,log_other_mut_burden,False,58,0.03938384606319314,0.12930707300386837,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01680438391958706,0.12415454319339765,0.8928033818145766,-0.265326703765876,0.2317179359267019,54,7,61,1,log_other_mut_burden,False,58,0.03059116648492602,0.16103625773326963,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0016600952252916806,0.09253269656265233,0.9857477878406629,-0.18356422133927522,0.18688441178985857,54,7,61,1,log_other_mut_burden,False,58,0.02284907596760439,0.06885391562898287,0.998906982267571,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09924155986048892,0.10139942797767616,0.33178359378272615,-0.30221456772572886,0.10373144800475102,54,7,61,1,log_other_mut_burden,False,58,0.027507567203786346,0.06329624043695958,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07519240626787545,0.14793653054954656,0.6131884797066596,-0.3713195460126886,0.2209347334769377,54,7,61,1,log_other_mut_burden,False,58,0.03660423498855091,0.06064042339628685,0.9552990821084932,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08799313631309033,0.10629462411034282,0.41116404614261937,-0.3007649438654093,0.12477867123922862,54,7,61,1,log_other_mut_burden,False,58,-0.012078893847406092,0.048706494771574065,0.9258730384511746,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04301759883171174,0.134356053881044,0.7499854480055062,-0.3119604609861569,0.22592526332273338,54,7,61,1,log_other_mut_burden,False,58,-0.05863884535628358,0.0013018272818809326,0.9644346245002389,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052645079238610046,0.12595072264805957,0.6775040839600238,-0.3047628429039582,0.1994726844267381,54,7,61,1,log_other_mut_burden,False,58,-0.023402327144704846,0.055076975032869936,0.9619695749374265,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060753244117080774,0.13051032624626865,0.6433129255958516,-0.32199804602573556,0.20049155779157402,54,7,61,1,log_other_mut_burden,False,58,-0.0218684438292345,0.013576850785970897,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01758629974751124,0.1766204409381226,0.9210281653224294,-0.3711305244307922,0.3359579249357697,54,7,61,1,log_other_mut_burden,False,58,0.01702912837877615,0.1780163005844572,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08077469255142578,0.15504196410832474,0.6043600205325688,-0.3911249028832775,0.22957551778042595,54,7,61,1,log_other_mut_burden,False,58,0.14175082398770247,0.22915636107123544,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0073963123775979385,0.15006224852445865,0.9608588889432865,-0.2929859142039586,0.3077785389591544,54,7,61,1,log_other_mut_burden,False,58,-0.1295076812291129,-0.0011895271060909454,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.160463033491388,0.19037450755446217,0.4027576514731265,-0.5415390137986942,0.22061294681591817,54,7,61,1,log_other_mut_burden,False,58,0.07301678501366869,0.06520357881558815,0.923447045283853,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02123561405962609,0.13034831700956925,0.8711521603564594,-0.2821561192465867,0.2396848911273345,54,7,61,1,log_other_mut_burden,False,58,0.043136508149598865,0.1313353095016018,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038759109880918206,0.11811436606564067,0.7439807418348312,-0.2751907015632418,0.19767248180140543,54,7,61,1,log_other_mut_burden,False,58,0.009963061091456173,0.06500896157585877,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046625669145496415,0.09550544855125084,0.6272495021537883,-0.23780059534166847,0.14454925705067567,54,7,61,1,log_other_mut_burden,False,58,-0.09957794199827115,-0.08719364676143086,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01612003546742616,0.07794429718009557,0.8368788366347197,-0.13990242698738334,0.17214249792223565,54,7,61,1,log_other_mut_burden,False,58,-0.08391625162254437,-0.005591263257977006,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03933737649774317,0.10295817049770696,0.7038047486101625,-0.24543054651860935,0.16675579352312303,54,7,61,1,log_other_mut_burden,False,58,-0.038202417581803955,0.020811790992731855,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05664292219626618,0.21110478503645702,0.7894076444711295,-0.36592921699793135,0.47921506139046377,54,7,61,1,log_other_mut_burden,False,58,0.0015971040562024693,0.25779914806101745,0.9727286373504853,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06600601797946333,0.08158675818776544,0.421805138428777,-0.22931965831864287,0.0973076223597162,54,7,61,1,log_other_mut_burden,False,58,-0.10500885805359007,-0.14868492684403836,0.9282753503874777,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054421003698807875,0.08330178575961016,0.5161448657082324,-0.22116764471434014,0.1123256373167244,54,7,61,1,log_other_mut_burden,False,58,0.04820583383137758,0.04378790146905924,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057428729225346455,0.14351502270819555,0.6905099677892848,-0.344705259417842,0.2298478009671491,54,7,61,1,log_other_mut_burden,False,58,0.05540507618010574,0.12446661843116127,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04525403538109131,0.08535278826867178,0.5979974541761841,-0.21610620397903796,0.12559813321685537,54,7,61,1,log_other_mut_burden,False,58,-0.03382832937182029,0.0012911019187896247,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.063769089962094,0.13239058753246927,0.6318501381663209,-0.328777643762098,0.20123946383790997,54,7,61,1,log_other_mut_burden,False,58,0.11009486247880812,0.15067524163064291,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056118020113621256,0.07304253342656025,0.44543050469003875,-0.20232853635982972,0.0900924961325872,54,7,61,1,log_other_mut_burden,False,58,-0.004665123627417255,-0.014040763840200862,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08112377969916867,0.10128071123813881,0.4264125742585263,-0.283859150191216,0.12161159079287864,54,7,61,1,log_other_mut_burden,False,58,0.034525722977811736,0.04979213443976192,0.9299900056018157,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08012828751217853,0.19804167521776947,0.6872575221203976,-0.47655177138499993,0.31629519636064285,54,7,61,1,log_other_mut_burden,False,58,-0.0023734506817452744,0.11858696359495889,0.9631797688191589,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08719471577253826,0.15057811492675505,0.5647866742879897,-0.3886095611510545,0.214220129605978,54,7,61,1,log_other_mut_burden,False,58,-0.03141411803461306,0.03784157336117883,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09006509745142992,0.09162422713405166,0.32969839660482303,-0.27347091487695546,0.09334071997409561,54,7,61,1,log_other_mut_burden,False,58,0.02911511806748116,-0.04016720661222033,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11669947106656522,0.2264710627167446,0.6083052173701087,-0.5700305569596251,0.3366316148264946,54,7,61,1,log_other_mut_burden,False,58,-0.08440383415931405,0.008983551943399868,0.9537283854402375,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10130231780139672,0.1295881061356258,0.43755553672348435,-0.36070109559034735,0.15809645998755395,54,7,61,1,log_other_mut_burden,False,58,0.019092187941474537,0.057792675822158586,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12691143516464914,0.169799202375546,0.4578292668033497,-0.46680146735369477,0.21297859702439648,54,7,61,1,log_other_mut_burden,False,58,-0.050095006427149986,-0.08571818413072174,0.9362244046839282,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04580333239807751,0.11387068982927695,0.6889860806742192,-0.2737402831610202,0.18213361836486522,54,7,61,1,log_other_mut_burden,False,58,0.10567650743143177,0.2188366508535106,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12929765036843396,0.1638156157265459,0.43315864774375024,-0.4572102325442782,0.19861493180741022,54,7,61,1,log_other_mut_burden,False,58,-0.26954280395796787,-0.25563577118295283,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10796175285264517,0.14887215397898118,0.4712465680732556,-0.4059617463747335,0.19003824066944316,54,7,61,1,log_other_mut_burden,False,58,-0.10248375053406569,-0.059793985354185016,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.051148824311914615,0.17718713384438112,0.7738622067889961,-0.40582740809379436,0.3035297594699651,54,7,61,1,log_other_mut_burden,False,58,0.04299073954994622,0.1954476213060387,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0028561625099672184,0.1924072724527107,0.9882072958894329,-0.3880011638552542,0.3822888388353197,54,7,61,1,log_other_mut_burden,False,58,-0.03472845950142826,0.14654270007378306,0.9990191441902606,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11017544035179869,0.12428705089113525,0.37903084639311935,-0.35896300317343277,0.13861212246983542,54,7,61,1,log_other_mut_burden,False,58,-0.1115258979691055,-0.0674484734272872,0.9183506089424412,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2955837833798991,0.09422469975168697,0.002680906200464018,-0.48419501231118617,-0.10697255444861203,54,7,61,1,log_other_mut_burden,False,58,0.8038415967027416,0.5686300473639944,0.07911164839882295,0.7560459172479591 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013487601173383892,0.11969883313126073,0.9106737711309185,-0.2530908482840115,0.2261156459372437,54,7,61,1,log_other_mut_burden,False,58,0.09021992344552937,0.22877097845863198,0.9891749114349121,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015170254647106042,0.10253527504751417,0.8828941492828267,-0.19007639815714378,0.22041690745135584,54,7,61,1,log_other_mut_burden,False,58,0.09289751776997278,0.2359434291769185,0.9870713197539774,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14532184187416736,0.1218904461206606,0.2380249614911257,-0.38931207902415654,0.0986683952758218,54,7,61,1,log_other_mut_burden,False,58,-0.11233330905565814,-0.12725053889209664,0.8459452857747916,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0228419971266273,0.10862575123898827,0.8341848730561565,-0.2402800626101211,0.19459606835686652,54,7,61,1,log_other_mut_burden,False,58,0.023861571568739273,0.12345799743496766,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15279907564687778,0.11989989150281506,0.20760806542963708,-0.39280478481517944,0.08720663352142391,54,7,61,1,log_other_mut_burden,False,58,-0.15890246418564846,-0.16331586309308527,0.8210381131305959,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15498455803381536,0.1217074943984571,0.20794963483136805,-0.3986085775227153,0.08863946145508456,54,7,61,1,log_other_mut_burden,False,58,-0.11572582398266308,-0.11643298088107404,0.8210381131305959,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09890207554128931,0.11054314108272922,0.3746496120051911,-0.3201782137989219,0.12237406271634328,54,7,61,1,log_other_mut_burden,False,58,0.017895631219311536,0.015949255244965727,0.9159127256227925,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06094378100734774,0.07127953501116713,0.39607094311904,-0.20362527250094345,0.08173771048624798,54,7,61,1,log_other_mut_burden,False,58,-0.05138796162088282,-0.09879576898427489,0.9212557438608796,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07483410874355428,0.15142081733511978,0.6230225472194024,-0.37793580626682555,0.22826758877971698,54,7,61,1,log_other_mut_burden,False,58,0.03404513084998191,0.06284562469908964,0.9584620018167673,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10742471535545763,0.12201008975121577,0.3822452503476854,-0.35165444525259565,0.13680501454168043,54,7,61,1,log_other_mut_burden,False,58,-0.06463668642696392,-0.0866673614429374,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09751530863292453,0.2252668643196125,0.666701709249842,-0.5484359295400654,0.35340531227421634,54,7,61,1,log_other_mut_burden,False,58,-0.025254735232882842,0.12108770459576143,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12061545617049718,0.14869551476083306,0.4205916129041415,-0.4182618678812327,0.17703095554023834,54,7,61,1,log_other_mut_burden,False,58,-0.07477469041230506,-0.07319773818140338,0.9279200175745067,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07109778714084011,0.14969146937337735,0.636597616443761,-0.37073781861292066,0.2285422443312404,54,7,61,1,log_other_mut_burden,False,58,-0.07089613800392557,0.001060224657190943,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06318965108307087,0.23133508635037386,0.7857066217375352,-0.526257138126862,0.39987783596072035,54,7,61,1,log_other_mut_burden,False,58,-0.010007474475630773,0.08762850632792443,0.9722536916492144,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03604777123026407,0.12346014840114874,0.7713445215120716,-0.283180108880009,0.21108456641948084,54,7,61,1,log_other_mut_burden,False,58,0.06055064010977249,0.12274184045190929,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01920643119711747,0.16827802730100944,0.9095248734421535,-0.3560515006430173,0.3176386382487824,54,7,61,1,log_other_mut_burden,False,58,-0.22684997488966369,-0.21887391300871895,0.9890879681893895,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18284364334221065,0.149226584613928,0.2254240617209186,-0.4815531068631887,0.1158658201787674,54,7,61,1,log_other_mut_burden,False,58,-0.10699044284247347,-0.0882650438466481,0.8397072744911553,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011082421274350687,0.07266519278815903,0.8793112872138187,-0.1565376081671929,0.1343727656184915,54,7,61,1,log_other_mut_burden,False,58,-0.031830721557384145,-0.009383747272041406,0.9864402192918322,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07113217135079214,0.09776363523876323,0.46978958383820835,-0.2668273493218218,0.1245630066202375,54,7,61,1,log_other_mut_burden,False,58,0.11263841042925941,0.08601106652298089,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09956402342225121,0.08069349699197896,0.22223370766439862,-0.26108960720791646,0.06196156036341405,54,7,61,1,log_other_mut_burden,False,58,-0.08687587880847776,-0.1728124511769176,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0009172733022490207,0.14518968113064015,0.9949808721522948,-0.289711449934425,0.291545996538923,54,7,61,1,log_other_mut_burden,False,58,0.1342267127015296,0.14535235701566754,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06542806456237786,0.09317783643222181,0.4853724129602247,-0.25194376888358117,0.12108763975882546,54,7,61,1,log_other_mut_burden,False,58,-0.20016605332438023,-0.27613473793342713,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07096825806557473,0.09373412991024041,0.45204111031957706,-0.25859750476804383,0.11666098863689438,54,7,61,1,log_other_mut_burden,False,58,0.07795872023449943,0.051199040675774236,0.933731420853472,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09745460387841576,0.06767562878470683,0.15523645544646741,-0.232922093267286,0.03801288551045448,54,7,61,1,log_other_mut_burden,False,58,-0.04651165845279218,-0.11467997059383953,0.7740370498329512,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03152302399268445,0.08848278851324,0.7229373326431605,-0.20864056880556217,0.14559452082019328,54,7,61,1,log_other_mut_burden,False,58,-0.04441305161131574,-0.004587221534169739,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13593609334922283,0.08874260348173116,0.13100799223948917,-0.31357371432717196,0.04170152762872631,54,7,61,1,log_other_mut_burden,False,58,-0.011463764972100221,-0.11280964905299558,0.7360778123788349,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00047872220456672245,0.09725318104732701,0.9960893750440931,-0.19419467068660984,0.19515211509574326,54,7,61,1,log_other_mut_burden,False,58,-0.01536152428196396,0.04521632169612387,0.999543673283893,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12498210687079554,0.10000712544881205,0.21641694519318314,-0.3251681184207886,0.07520390467919748,54,7,61,1,log_other_mut_burden,False,58,0.06975786744873892,-0.04853891997704327,0.8295752524063543,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07292397259077756,0.10500787046014504,0.49016508965941274,-0.2831200628637079,0.13727211768215275,54,7,61,1,log_other_mut_burden,False,58,0.1261287918817924,0.08909763784696434,0.9418332435783486,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05398336782126649,0.07296395577497573,0.4623671408778871,-0.20003659380843514,0.09206985816590217,54,7,61,1,log_other_mut_burden,False,58,-0.1628196528099443,-0.21063215344253913,0.9372011503139762,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05862746488885523,0.11058568775433679,0.5980289112359616,-0.27998876956293683,0.1627338397852264,54,7,61,1,log_other_mut_burden,False,58,0.06389931758505668,0.02427047058088935,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05807740883168201,0.09446575945602201,0.5410923566551225,-0.24717117118785942,0.13101635352449537,54,7,61,1,log_other_mut_burden,False,58,0.004067160458057041,-0.03181783470341491,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0255068977058481,0.10335261002692335,0.8059383986793615,-0.23238962422878476,0.18137582881708855,54,7,61,1,log_other_mut_burden,False,58,0.005441255124309352,0.023116783495170008,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1420836270966737,0.10850245152146369,0.19552980974736064,-0.35927488137980834,0.075107627186461,54,7,61,1,log_other_mut_burden,False,58,0.03223561093783284,-0.08122233574435514,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07619373065237905,0.11042172205912441,0.4929304657323129,-0.29722682232755404,0.14483936102279593,54,7,61,1,log_other_mut_burden,False,58,0.0021696153928577534,-0.011281918395517994,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07882763909145714,0.07071487574949908,0.2695661041474157,-0.2203788422683874,0.0627235640854731,54,7,61,1,log_other_mut_burden,False,58,-0.06714833395383286,-0.08849946495785041,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030571167184387262,0.10593944458645814,0.7739376867090737,-0.24263200567373586,0.18148967130496133,54,7,61,1,log_other_mut_burden,False,58,0.3555150246385562,0.5390976036618587,0.9692333998776356,1.0 +ENTREZ:324,ENTREZ:7468,APC,NSD2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11474598359198844,0.17285563727732142,0.509432248831823,-0.4607541349630697,0.2312621677790928,54,7,61,1,log_other_mut_burden,False,58,-0.13002042686147758,-0.34411881408358125,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13856742303781538,0.1681259912544975,0.41145442529828213,-0.19428232197835205,0.4714171680539828,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13553543610826474,0.24184778914237318,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13300594999242835,0.1495693516462115,0.3756282052017056,-0.16310603237391033,0.42911793235876705,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1696219442757489,0.21492721845129117,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10593426175300392,0.0740882408759979,0.15534020454829003,-0.04074295275895877,0.2526114762649666,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.25299795875963366,0.03600168921388743,0.7740681379185977,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1153484869536226,0.17760053289064576,0.5172573884250632,-0.23625861225987005,0.46695558616711524,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.08967871326557583,0.42752437465460524,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1315776193963058,0.10142225798736823,0.19698748566725535,-0.0692144916756722,0.3323697304682838,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.148408176847641,0.13042479260409462,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0929837646505249,0.09991940969623143,0.35391985818250005,-0.10483306183416012,0.2908005911352099,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.34524014582844315,-0.03847420446671863,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04467586495094215,0.12415893098538161,0.7196029943782414,-0.20112948740179046,0.29048121730367477,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09218504055972898,0.14750039266179643,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13222704671894284,0.08528776502449371,0.12366592101519656,-0.036622579859197174,0.3010766732970829,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3822589741976117,0.020074069681544657,0.7255706347976272,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055099922255080924,0.0950968842510373,0.5633909023855541,-0.1331694431095858,0.24336928761974766,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07079146472372895,0.09162526361244228,0.9517337695544857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13570395284956602,0.1556412924679995,0.38498862791248345,-0.17242903792365297,0.44383694362278503,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.06524781827550226,0.3534979240061717,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11951228757514583,0.09995888722758348,0.23418494585542277,-0.07838269509554201,0.31740727024583365,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14100449692061362,0.23564639457632972,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060081761351988464,0.16254368908311126,0.7123009322363709,-0.26171634411407224,0.38187986681804914,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.10930442458084798,0.3093317292669472,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12313048643426035,0.11478313392244598,0.2855302800326751,-0.10411300264893465,0.35037397551745536,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09434925382512795,0.23308451616112416,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09858962697928707,0.09847236438294102,0.3187325575269964,-0.09636239163148351,0.29354164559005763,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16060143510696756,0.12409848851239542,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052075813639674555,0.19718522951892017,0.7921552888929992,-0.442455985536929,0.3383043582575799,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.18755442892562135,-0.14410200231111148,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029767921855040173,0.08017189499405879,0.7110625298586748,-0.128953490623303,0.18848933433338336,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.7385001340849425,-0.33675241370318465,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03296007138277337,0.07875380704715365,0.6763086141133012,-0.12295386196628172,0.18887400473182847,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0057076961786060735,0.0730271226936082,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11312783507951174,0.09847332499051284,0.2528973412322271,-0.08182608530731947,0.308081755466343,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16768134480570365,0.19452034458143205,0.8623277898201971,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051425895712827345,0.09847545788927223,0.6024716144100798,-0.14353224730967673,0.24638403873533143,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03558815459706033,0.1258838489094938,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09304999874516695,0.09880747225122997,0.3482070698285302,-0.10256545427976299,0.2886654517700969,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.15224116832209048,0.17979338059518013,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18138937715335846,0.13681765195855275,0.1874118250622049,-0.08947725226136505,0.45225600656808196,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10629231889028823,0.24821603586591165,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10408958500758801,0.15599221759195903,0.5058675571202182,-0.20473815460938877,0.4129173246245648,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19088419027729903,0.20156805342813575,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1391338558470099,0.08629024832534264,0.10948155809713675,-0.03170045084263906,0.3099681625366589,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2670693718011217,0.026823760002129816,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009082495973204487,0.16912114479399976,0.9572594968833676,-0.32573741795857014,0.3439024099049791,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.018720874052435492,0.26004284480492673,0.9957512552242196,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07767660097978274,0.1168682504025073,0.507538457048833,-0.15369492615118113,0.3090481281107466,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.15690358163008652,0.13858655043873247,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15205385900794746,0.08303584021295206,0.06953334804318799,-0.012337488432479699,0.3164452064483746,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.23745851690773506,0.14793894799809967,0.6098958196318522,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06868341948542488,0.0984077730614475,0.4865493547691908,-0.12614072356768236,0.2635075625385321,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.23278788732321734,0.051028335806953186,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14156874014907747,0.07302300133727015,0.05486806449562542,-0.0029995517257543902,0.28613703202390933,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.29901606124933533,0.12113615086858813,0.5490443949486614,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13167084795062572,0.10549916466173054,0.2144134198194408,-0.07719257521825512,0.34053427111950657,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.17324258470385726,0.15490723864038608,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13511246207597175,0.09090786097817155,0.13981209431422056,-0.044863626812902874,0.31508855096484634,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06803472330814508,0.20468319873774513,0.7565292465346168,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10226164277632567,0.1019537202949112,0.31785273675373843,-0.09958263811324829,0.3041059236658996,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06429936158143813,0.2362987433394192,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055649576962379,0.13149746180140454,0.6729014040207904,-0.20468433276973608,0.31598348669449405,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09418019988857129,0.11305169156056363,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04089945149490635,0.15248130228314793,0.7889820923655182,-0.26097750522056073,0.3427764082103735,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04728641074439388,0.17548182824828903,0.97265722149363,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07678195640206281,0.09332308201866302,0.4122662866975155,-0.10797569958114864,0.26153961238527423,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.043313390126318206,0.13324658398715022,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10233042082725155,0.13787256310497675,0.45939834176951877,-0.17062468344779522,0.3752855251022983,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.024810809478339656,0.24582966582820598,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11766497361003124,0.10225393762275178,0.25211914009227293,-0.08477366666606916,0.3201036138861316,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.24586191723012765,0.016306752315929242,0.8604134712177398,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20358201618492508,0.12096342928507928,0.09495274427944776,-0.03589699769861554,0.4430610300684657,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13676420185549318,0.22629819976926852,0.6729775750805861,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07015079741553013,0.07670458497578078,0.3622425761333993,-0.08170616033535305,0.2220077551664133,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.324219401378047,-0.05046700408778477,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04453204623674945,0.08239438297363504,0.5898634590655945,-0.11858936740609938,0.20765345987959827,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.22599257112827761,-0.007037797413309205,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08271037820417676,0.0666746961494695,0.21718818659681954,-0.049289769106703074,0.2147105255150566,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1369597437146825,0.08180616499527811,0.8308625663641223,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0639840514214169,0.08117322608054339,0.43209739042468764,-0.09671976005619017,0.22468786289902398,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.22205642852188376,0.0015635535925451016,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05507640512621755,0.08042163793917938,0.4947511258401194,-0.10413943938480963,0.21429224963724475,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.013735161024705692,0.15977890940542885,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12095191799750458,0.07502971703170838,0.10955564818353639,-0.027589196890769815,0.26949303288577897,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08550910275746876,0.09134827279546216,0.6985162532376802,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11952487120941621,0.07956860659745278,0.1356607726338379,-0.038002172763003605,0.27705191518183603,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12382462390451715,0.17616224326606697,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08849877383778837,0.057309947221184446,0.12514809929298595,-0.024961382900178034,0.20195893057575476,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10347498466141547,0.07968218900002166,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06505621751546878,0.07723075958541119,0.4012475585341987,-0.08784244166029612,0.21795487669123367,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08520230054106252,0.08505034169058259,0.922683406617749,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09652092551585242,0.10621273782774526,0.36528809140431295,-0.11375520394898031,0.30679705498068516,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03657626150550463,0.1551858166876158,0.9138534098857347,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02709106475630975,0.06639035846295628,0.6839528250036431,-0.10434616110650467,0.15852829061912416,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.012107933709326705,0.05939902414649943,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08083639609903587,0.06049415815147592,0.18396927138372252,-0.038927746050804554,0.2006005382488763,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07438146674530098,0.034970498235057754,0.8036298987262369,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0701177883925635,0.07791231704553907,0.36993037558175923,-0.08413019354480838,0.22436577032993538,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13331819515808957,0.0964262004109215,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026854642278894406,0.07062001707706221,0.7044120377850147,-0.11295630843577535,0.16666559299356415,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12875622431727227,-0.00932744337548704,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05419422935936103,0.07811515933324861,0.48915398326913684,-0.10045533238871615,0.2088437911074382,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.45608312666393624,-0.06301970473932872,0.9413101379855534,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1117170251095952,0.15281490129296246,0.46615517193683154,-0.1908203788367009,0.41425442905589127,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.15337815983441752,0.1382595097991931,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14404112595319518,0.1448777136605984,0.3220971469856878,-0.14278252154256643,0.4308647734489568,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1946381075642808,0.1877800522791564,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10798795747141098,0.10314959755048357,0.29722959526392556,-0.09622387787311552,0.31219979281593746,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07238145034287123,0.14841816669329258,0.8843360296870468,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1774667806345383,0.14047811466895027,0.20890815531802248,-0.10064670020812833,0.45558026147720493,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0303323287480143,0.3359793463888759,0.8221680401162432,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11198352108006814,0.09420193061233567,0.2368617733439205,-0.07451404750160025,0.29848108966173653,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.17660925338612674,0.10611050593081571,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14819446147986512,0.1988772830123528,0.45762279664929073,-0.2455355766078597,0.5419244995675899,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.09291897794613999,0.40947226844342477,0.9362244046839282,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04473090254815326,0.10376988312488085,0.6671927039566402,-0.16070895169895216,0.2501707567952587,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03330888457930566,0.15289582761166018,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15883592261571527,0.11936774921190323,0.185808525195938,-0.07748402168244486,0.3951558669138754,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.024012658169306443,0.291566052778239,0.8073060060237306,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07513775363910105,0.08862742966095473,0.3982269131127799,-0.10032361996513017,0.2505991272433323,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2701215051311811,-0.005250771956329276,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015839646799551448,0.09589788506749858,0.8690842274807296,-0.17401551095525977,0.20569480455436265,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.06414830772517612,0.1102699048652863,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06833444312892094,0.10127528062366178,0.5011284225593233,-0.13216668748448668,0.2688355737423285,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16749004708604,0.05976143293551433,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09105444557323232,0.14937532615184587,0.5432908476853002,-0.20467341215036466,0.38678230329682933,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.011097985252460241,0.23266218882649375,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05094017331499901,0.10315492948210842,0.6223271104995365,-0.15328221799454236,0.2551625646245404,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.21702525834467828,-0.01746544884174749,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1469697561815992,0.10771394915531073,0.17495982455167503,-0.06627841706936755,0.3602179294325659,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.28203570079937423,0.08924393273980134,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060198308944066165,0.0873841286977351,0.49220946306588653,-0.11280162246733016,0.2331982403554625,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10310225354040065,0.04037060515175845,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14742117957655682,0.09297238958480773,0.1154299400676171,-0.0366421882343331,0.3314845473874467,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.4463107645811389,0.04679475468881357,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09902174908291544,0.08872845078999841,0.26662967601314774,-0.07663962249184098,0.27468312065767186,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.32404337840662356,0.0067770490589702526,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15589219402170076,0.09370575935122034,0.0987732624606308,-0.029623072677229023,0.34140746072063055,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3757761927235116,0.01668180002704388,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05514658183200335,0.08216439237916803,0.5033891159362143,-0.10751950476620917,0.21781266843021588,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.03014680233726256,0.16385794213133978,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12659782717161489,0.09781480075710379,0.19804017837961857,-0.06705237080120019,0.32024802514442996,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08712865308759399,0.17437357697661637,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11644703073260787,0.08058634175532803,0.1510434779347541,-0.04309488842517209,0.2759889498903878,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1555337816592654,0.11580006013646539,0.7686319965021204,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1822825788215822,0.150784872416096,0.22906144615812796,-0.1162358475175119,0.48080100516067625,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0024761127946585824,0.44095662055930596,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12651669322547665,0.09140413337088256,0.16886128576421572,-0.05444189776280495,0.30747528421375825,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2895562146104545,0.002558574946086935,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0895653104384497,0.1310733437633127,0.49570970904913303,-0.1699289457708383,0.34905956664773774,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.06317570238106429,0.30546135454988527,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08652278221396317,0.10110824034578458,0.39383072289651266,-0.11364764811042907,0.28669321253835545,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03197321668197943,0.13161858829698736,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11814566963247254,0.09732549004413094,0.22714112074689854,-0.07453580872220712,0.3108271479871522,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.02804444401314157,0.23650304903435385,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060366165382348784,0.08764938406365291,0.49231590383359014,-0.11315890899029418,0.23389123975499176,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05939649562118952,0.1401735188015993,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09230639471791952,0.07100758899630454,0.19608863307405103,-0.048271856837819815,0.23288464627365885,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.012153485861670976,0.09984860482115716,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11358147807424464,0.09800876448055867,0.2487826072720845,-0.08045272224950152,0.3076156783979908,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.040969082805839226,0.2687272109892375,0.8577318021260126,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08564681195183703,0.08695421789547267,0.3266069772877689,-0.08650199763214277,0.2577956215358168,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.027655176033904428,0.09912174658314875,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06766015519603577,0.08245812482824416,0.4135221473249914,-0.09558745226072127,0.2309077626527928,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08525066842357286,0.09376675159973653,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04781819312419651,0.07529533443163522,0.5265785339194722,-0.10124878146713638,0.19688516771552939,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.005198156803419814,0.06362487186051684,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12586282054351144,0.06894339985758018,0.07037713945966574,-0.010628824156482947,0.2623544652435058,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10869334076203369,0.16521836557697325,0.6139052011327766,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13679953755497976,0.08856217009882322,0.12503694903692342,-0.038532637532988384,0.3121317126429479,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09733656121050605,0.14315759461716235,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0021435846459430937,0.16444992427965688,0.989621434537328,-0.3277155854768829,0.3234284161849967,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.21428362510382423,0.18321856652754182,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0871281073231981,0.13028783657351728,0.5049380105353052,-0.17081103021656785,0.34506724486296403,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04522987074711875,0.23635761917703654,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10218832263793333,0.11932672895097568,0.39348365140113795,-0.1340504112341151,0.3384270565099818,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06738978894934261,0.2087609695349422,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07575162922858134,0.08039137521355115,0.34792401456435607,-0.08340430223489331,0.23490756069205598,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19703275249009833,0.012130515703083473,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12008855644835582,0.12283921364396042,0.33021891677608284,-0.12310406733511871,0.36328118023183037,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.046873623640836935,0.2822333135689281,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0833458152700473,0.1026537283315417,0.4184363890824324,-0.11988431616389035,0.28657594670398495,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07480890466356026,0.12715938506318786,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09333861018849214,0.09464489272894713,0.326003856616371,-0.09403591873979368,0.280713139116778,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09468455119444227,0.21028594272668982,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14671419058687224,0.10147114612278373,0.1507985775653864,-0.05417470744401645,0.3476030886177609,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16608341384508563,0.12446689670803714,0.7683177847971997,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14340630323187384,0.1388953017402581,0.30390763299124174,-0.13157358193178806,0.41838618839553576,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.009709145801723815,0.3360600506185437,0.8913059585247131,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07120861599232828,0.07266421651556314,0.3290571632542262,-0.0726493666939613,0.21506659867861785,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.4297267245946385,-0.030635617624963033,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08015398875747601,0.0901010791536765,0.375445547774805,-0.09822486271103828,0.2585328402259903,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3827249194856672,-0.01484721967366869,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1554089109278975,0.13958643359944067,0.26776388622439834,-0.12093925204566736,0.43175707390146234,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03563528639655847,0.26790960369172667,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1720932932398568,0.1469724913326559,0.2439310072282549,-0.11887751918149006,0.4630641056612037,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06573013835628402,0.2577377858138087,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11808171532735146,0.08712837923187002,0.17785889241900418,-0.054411892559252356,0.2905753232139553,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.30271870520084865,0.06252322616141195,0.7948003040850444,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05496187647045018,0.054979640358323194,0.3194618709446717,-0.05388482318497222,0.16380857612587257,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11987790262561339,0.054236558543073445,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0020587956850657194,0.04983515580876163,0.9671151657313375,-0.09660303988251226,0.10072063125264369,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04038438735836935,-0.005291196212467429,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07383887244041362,0.08032769328083268,0.3598090190500145,-0.08519098384034052,0.23286872872116776,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2504501343064757,-0.010540094883371015,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007444944186678072,0.11004504921658388,0.9461730490322235,-0.210418256492305,0.22530814486566114,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.32473713384498376,-0.10518670996806535,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13622771000280795,0.08351853155868819,0.10546779711961879,-0.029119252272368806,0.30157467227798473,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19886825340041048,0.10237535603256297,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07833620442233351,0.08989092982025905,0.385229731736066,-0.09962660101117222,0.25629900985583925,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3931769964866514,0.013827764939884,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09631493821230758,0.09638935653394635,0.3196783651262696,-0.09451321694206832,0.2871430933666835,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.22283860124110366,-0.01536117668293641,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037444269540379195,0.09518655805385026,0.6947328045649472,-0.15100262876954015,0.22589116785029853,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.31856542390938575,-0.028520796096818866,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004114041649235635,0.0612270584924639,0.946538805337263,-0.12532915333567105,0.11710107003719977,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.022628122389304037,-0.003780762189863606,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035611191254181614,0.06753235838858662,0.5989366343032363,-0.09808692467814711,0.16930930718651033,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.13221016467846824,-6.658318616827427e-05,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08744931449346233,0.0741717811891526,0.24070712995445367,-0.05939329010319003,0.23429191909011468,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08009574636569121,0.07139099385440842,0.8476072767807353,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09320199557584244,0.09100862593703397,0.3078307774237233,-0.08697358412711548,0.27337757527880036,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14869823576880223,0.1156715412153155,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07854982090536397,0.0895641692073634,0.3822121840621726,-0.09876607570772622,0.25586571751845416,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2105451503980968,0.0916685554709913,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08754565174234236,0.15565658546234115,0.5748648177132049,-0.22061761554689402,0.39570891903157873,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08549578524928846,0.24181338013706238,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06009265046030142,0.06883538457173316,0.3843973039908739,-0.07618514949097945,0.1963704504115823,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2940972007504839,-0.08762736933802985,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08138036133675976,0.10473068104441924,0.43864921072969,-0.12596164581451097,0.2887223684880305,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05248000114611309,0.18894890620529384,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12451889692886282,0.0972122377650998,0.20267936109206663,-0.06793836866777307,0.3169761625254987,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2667455966607736,0.09134115929746094,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12700202866363675,0.11470839547882349,0.2704153444365638,-0.10009349595721054,0.354097553284484,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08483750369551364,0.25764733837280684,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06128034195721545,0.0966718118066182,0.5273420549297112,-0.13010700791051671,0.25266769182494764,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11732079000710449,0.09612025569842515,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11752530586676839,0.13122166456338452,0.3722317428656573,-0.14226259048772338,0.3773132022212602,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09911820604157669,0.17745120445471615,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07838110306225402,0.08580823261449146,0.3628250573305516,-0.09149892639010723,0.24826113251461526,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2608602155222256,0.024778812877444625,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056583867132291556,0.15927029894900577,0.7230062982581172,-0.25873369916581757,0.3719014334304007,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.01298957940909733,0.2516360040352968,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07994008630491418,0.11978535085494524,0.5058122513392036,-0.15720661059329138,0.3170867832031197,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.21380314983876025,0.12907615641134612,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039590819554793294,0.1426819778472353,0.781888173519148,-0.24288578974569927,0.32206742885528583,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.03500766235608532,0.28911297415046794,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12756643965283654,0.11492971681418042,0.2692208013768592,-0.09996724892761338,0.35510012823328646,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.26279191023899445,0.07621832535649045,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06223741208988563,0.13241005650839832,0.6391757882868083,-0.19990321957296397,0.32437804375273527,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.03026599678970281,0.2844557925858848,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11025157421657486,0.10066845017061417,0.27560644174271165,-0.08904817545592161,0.30955132388907136,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.24176441398130094,0.06844397205452109,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05038212677584402,0.06136862473474409,0.4132748628245193,-0.07111325262704773,0.1718775061787358,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3512642277524041,-0.045750868731394605,0.9263451842579509,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049642448546409514,0.07903957667346917,0.531141216727794,-0.10683724115324161,0.20612213824606063,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14170268278486262,0.0018740651181276447,0.9462574637850627,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12654288543094577,0.08545860562373413,0.1412722814098154,-0.04264496517473024,0.2957307360366218,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.19032577476341656,0.13354729449526612,0.7596261630193029,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1672357335316928,0.15582116079261693,0.2852927757270276,-0.14125335403262124,0.47572482109600683,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05069980788609831,0.3767050040272739,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02053212854769963,0.08225868865900486,0.8033165599673777,-0.18338489950366946,0.14232064240827022,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06446788570822709,-0.11305514116708469,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09958260507753469,0.07254619568957377,0.17239118529640116,-0.04404172425424352,0.2432069344093129,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11803463063656257,0.056117992073959844,0.7851068438799956,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13183718591207638,0.08364027462033935,0.11758136395063798,-0.03375079886489035,0.2974251706890431,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04991424367072255,0.18009984339600962,0.7176009922554474,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12748736929288573,0.08514233963077124,0.13690787482592653,-0.04107434936061857,0.29604908794639007,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.0797164988711913,0.11350407902277418,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08998364000167276,0.07777309032738867,0.2495504536243127,-0.06398870592433638,0.24395598592768192,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11991363094539728,0.09343740838826317,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1207445264846083,0.06259384679914234,0.056070673621454965,-0.003176503162366298,0.24466555613158292,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20772005723086256,0.08384505535896598,0.5518846108576955,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07928967723443722,0.08309845506678816,0.3419021970470767,-0.08522563282460743,0.24380498729348188,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07807517017887249,0.08513263142531301,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12702907573484426,0.14565647253924432,0.3848733326335019,-0.16133633036856773,0.4153944818382562,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.028291320993903534,0.28124284883007605,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058818362931550794,0.11066209597377022,0.5960376297319203,-0.16026644455706368,0.27790317042016527,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.07835618197812651,0.11798334462671146,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09400311829668273,0.05391780531145283,0.08379463670732532,-0.012741398811217733,0.20074763540458318,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10495917978837398,0.06048179148660856,0.6500804664849935,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12400812939207621,0.14889215263079583,0.40655776179567704,-0.17076315890355748,0.41877941768770993,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06974366921814479,0.26717452117466195,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11879400009740211,0.09703534003626821,0.22324211731588697,-0.07331304978602853,0.31090104998083273,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1876614086038562,0.13879678348402938,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11190061308265262,0.10122115786451627,0.2711336019816602,-0.08849336725347343,0.31229459341877863,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3065645886462802,0.05632997240722567,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024581155330103403,0.11523864436605817,0.831446863974122,-0.20356413682278482,0.2527264474829916,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06692821612521065,0.15229429842520892,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1083310637390901,0.10773499126240128,0.31664699631075083,-0.10495876791298067,0.3216208953911609,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.17370146003444134,0.19687910543709103,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06460477516843316,0.14395657057460362,0.6543933298168016,-0.22039522662561983,0.34960477696248615,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1522518577778572,0.052479488924932524,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056705780226120085,0.1329014029418068,0.6703738332421939,-0.20640760130041394,0.3198191617526541,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08818157966799897,0.12868744876946445,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1424458575959367,0.13083654072144402,0.27843602696752745,-0.1165795845322154,0.4014712997240888,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.007563899014828245,0.2944602766689452,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08254650918482363,0.09121123057113473,0.3672618307897838,-0.09803017983083685,0.26312319820048413,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14007497544925487,0.06304634504979531,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08518667546863609,0.17041125826143327,0.6180612523947417,-0.2521873583554469,0.42256070929271905,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3911638650806719,-0.0885357244644062,0.9572656024379023,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15244259606993368,0.11752781138401779,0.1970725576563481,-0.08023470599136837,0.3851198981312357,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.048438226493227744,0.22963644502646813,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10553731313533014,0.11047613532750158,0.3413331294399582,-0.1131793362045549,0.3242539624752152,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.04325269840878561,0.15708168814144918,0.9043732915535342,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.100235172401357,0.08155583831210592,0.22144259605972447,-0.06122612090737799,0.261696465710092,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.3167414308587802,-0.05134310988461507,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11201545040544181,0.09686017000109867,0.24976893797707275,-0.07974480419008839,0.303775705000972,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1239331148603677,0.14500756389382524,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06581867632211041,0.06804416529064689,0.3353267708488451,-0.06889269636830281,0.20053004901252364,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20398267082733848,0.009658797345849622,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08867402533666549,0.08691192751193702,0.309633887864262,-0.08339105927848917,0.26073910995182015,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2871141087369391,-0.03758743897858969,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009309635198793261,0.08832282302034006,0.9162292712494888,-0.16554868921653917,0.18416795961412571,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.01594755984751369,0.1619614078319935,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12229691634286559,0.07935454632979747,0.1258925388761969,-0.03480633886866412,0.2794001715543953,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.019226612556187756,0.10260319674151908,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16038211783443523,0.08435736516584155,0.059651160830393624,-0.006625536818931577,0.32738977248780204,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10897116115718977,0.18493911739905888,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040874946064507006,0.09110860861586526,0.6544939381268259,-0.13949857572287644,0.22124846785189045,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2311828137705182,-0.011619168507130035,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1431745605023501,0.15825435015755293,0.36741597015244076,-0.17013166719390843,0.45648078819860866,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12487037587289798,0.25959748938950716,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14362715916851032,0.11050408884225466,0.196159000071297,-0.07514483152691673,0.3623991498639374,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2772979865587529,0.12588008291136213,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05493888885881167,0.1464164720329046,0.7081512350878654,-0.23493113670164975,0.3448089144192731,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1465911661166859,0.07868411892633168,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16556326248472322,0.13995781559378376,0.2391476134908855,-0.11152014910327848,0.44264667407272495,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20858591113145855,0.24681016093448935,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09366179676229759,0.07501176435604817,0.2142115863629696,-0.05484377606926523,0.24216736959386043,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14882343107909118,0.10154749718276826,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0698539888504682,0.12259967919312678,0.5698879969828157,-0.31257239100831746,0.1728644133073811,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.4425606316234179,-0.06469866129395715,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10543885240779485,0.13641147178136828,0.44106098326053356,-0.1646236362111024,0.3755013410266921,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.022914920455804736,0.25359813044205626,0.9321464550378369,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06122098334672773,0.09055358668457282,0.5002834435530011,-0.11805372613370299,0.24049569282715846,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.10137383512993314,0.05507026417635926,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011846913904507412,0.08432241931222524,0.8885021837585376,-0.1787853840232358,0.155091556214221,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.08435856990746926,-0.02397113960669492,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06879522192069937,0.06962350184043517,0.32507376278979383,-0.06904286403974003,0.20663330788113876,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.16914842290958146,0.013026052796496587,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03175533199186234,0.0942234842974222,0.7366846258059739,-0.21829557177821285,0.15478490779448817,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11978535008899743,-0.06247363607080414,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03570899621176819,0.09783264699688672,0.7157479893234564,-0.1579765330998656,0.229394525523402,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.20441425881970282,-0.012354572863431095,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020308993328281573,0.06713599888001613,0.7627863136454834,-0.11260442441206614,0.15322241106862927,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09712370832346663,0.023027008671214617,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06052560361652802,0.06608109517449158,0.3615258614575557,-0.07029935399471955,0.1913505612277756,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.14016172668071972,0.029093377088016712,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06548540575816743,0.07944508772553856,0.41139944821061314,-0.09179710002765458,0.22276791154398945,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.062346664136532906,0.09416614464270727,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05818065178533702,0.06764160014556907,0.39141773992101025,-0.07573373701881486,0.1920950405894889,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09176876533334669,0.0383938039702422,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10699733896769707,0.08709530504775792,0.22164015632970846,-0.06543078984772811,0.27942546778312227,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.05385085830736442,0.11194621838081813,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03530659748967321,0.06648940819185543,0.5963846130831006,-0.09632672343709892,0.16693991841644534,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.12390328328764834,-0.020044699955084764,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03691358099824264,0.06283595336980703,0.5579897763733197,-0.08748676246399147,0.16131392446047677,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06522770167505264,0.027716693771676508,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08495572941161594,0.09801671880425028,0.38779598319255404,-0.10909421859392987,0.27900567741716176,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.1754584873918958,-0.03388815129113385,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020775608771271336,0.062024682761087184,0.7382374096868887,-0.10201861053825662,0.1435698280807993,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.11198332667281145,-0.014277554209011426,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05579233548987222,0.07710391344497541,0.47070836487625345,-0.09685519829364786,0.2084398692733923,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.020821784706828106,0.03924700043679474,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05449698871640886,0.08852227852687578,0.5392948661011594,-0.1207562104829895,0.2297501879158072,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.06323325449505489,0.07804774645039371,0.9471659478826966,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03205185139085115,0.06556410684150953,0.6258237597797293,-0.09774959145313519,0.1618532942348375,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09994691405974786,-0.024207690270784763,0.9600126145781049,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052578760145740776,0.08046876694604217,0.5147344114390673,-0.1067303886652349,0.21188790895671647,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.09255003097692675,0.04579889153743865,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0056729492584469444,0.06648585777450654,0.9321435198096506,-0.13729924119761006,0.12595334268071617,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,0.019699553279393805,0.07742903299673798,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08976511604662007,0.08106629172649948,0.2703584505216433,-0.07072699067188698,0.25025722276512713,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2834625737484844,0.00033637715862394363,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03995022720776519,0.08927252536370597,0.6553079576243573,-0.1367882834921025,0.2166887379076329,118,7,125,2,log_other_mut_burden|lin_Uterus,False,121,-0.2014883875023568,-0.011079897676485555,0.9604336667767839,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09651658553447545,0.056620316075306806,0.09011236785791381,-0.015262403978937925,0.20829557504788881,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.015123233961254659,0.10895465756768803,0.6623259037556665,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10482281604176939,0.05521019743795385,0.05932969800376642,-0.004172338140034343,0.21381797022357313,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.02129235282027423,0.12627096712892985,0.5680556875544357,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03946728655280203,0.03737602472810261,0.29250629409407813,-0.034319907969019126,0.11325448107462319,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.016919279101109696,0.013947099960850926,0.8801800464438181,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04940101554751615,0.06474409420922998,0.4465217700222128,-0.07841581645397759,0.17721784754900988,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.08578495712250188,0.2136163232436543,0.9330352189956562,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05909954960131111,0.04310414576077664,0.17217647348571843,-0.025996016636260194,0.14419511583888242,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.016086332759398286,0.12634028639399308,0.7850787711519817,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062451528671284305,0.04083895317443912,0.1280919104267698,-0.018172127907264295,0.1430751852498329,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03168161958528909,0.017687321694739386,0.7288842902994255,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029602145421247124,0.05085326508968934,0.5612735894893128,-0.07079161743982348,0.12999590828231772,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.055632883182156506,0.14192719463269063,0.9509691818071948,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04223740474778219,0.03618536281430229,0.24476303227332852,-0.029199202656162562,0.11367401215172694,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004714673446701024,0.04974349076418435,0.8534526629046483,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04557414964050917,0.035423141066216836,0.20001625320976055,-0.02435769087600209,0.11550599015702043,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0028543522047958687,0.08323296514285677,0.8150559640549688,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047618564099120554,0.06052833964094639,0.4325569659504319,-0.0718755876641961,0.16711271586243723,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0647033448633416,0.18965809447019838,0.9302388919528202,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0664267068664763,0.03925430374757748,0.09245888739033088,-0.011068558280417029,0.14392197201336962,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.012599672410218742,0.10664874770902665,0.6674195391201606,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05074451614888359,0.06332294856432677,0.42405486272397186,-0.07426671116599223,0.1757557434637594,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04312547267045335,0.19041329313147623,0.9291050235448216,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07268778140476626,0.0450555010005324,0.10855740498608084,-0.016260121449780063,0.16163568425931257,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008208142766704816,0.11567293362626323,0.6983214593026821,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054847147752167646,0.036935228732027495,0.13942972940378245,-0.018069833841889177,0.12776412934622447,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.010494965251012957,0.09298759437663107,0.7554902334520308,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12525119260872777,0.07797431730427912,0.11008301947611979,-0.028684549902461554,0.2791869351199171,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.1360759656968716,-0.030148062158069894,0.7000359361715495,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13443390764759158,0.06251621230389652,0.0329546433550294,0.01101532711121106,0.2578524881839721,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.13598080877057353,-0.10646911307594875,0.43476822754237954,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05398675286309539,0.03107877009819899,0.08420333576016004,-0.007368494823545964,0.11534200054973676,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.036264121237790166,0.056248836292388665,0.6514679135128171,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039398200071260644,0.043531265296040476,0.36673221116526467,-0.0465405792276742,0.1253369793701955,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04838347504714885,0.11517982547511299,0.9150244079451123,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04493410049222844,0.03732213758371615,0.23030131664385375,-0.028746710827152258,0.11861491181160914,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.009271601965525903,0.08969492029590354,0.842940686827401,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027141793732291072,0.039021789660984456,0.487668690099054,-0.04989444554811935,0.1041780330127015,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.038713854227164696,0.08070141975065527,0.940275458344982,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0723863107889067,0.056763416050212026,0.20398912290621388,-0.03967518457581676,0.18444780615363016,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.018313735507893784,0.09085445817775273,0.8179445630780711,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02309239185181016,0.052208094989816045,0.6588306186998647,-0.07997605613460132,0.12616083983822163,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07388240869954714,0.11893075496323322,0.9604336667767839,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04071924262850692,0.03937376026736604,0.3025421111302372,-0.03701185181073783,0.11845033706775168,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.00991775288410645,-0.006358092688500847,0.8904632102898862,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06496531545688676,0.06115277667536562,0.28960403174863053,-0.055761590652578366,0.1856922215663519,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05752668403577898,0.18416279495231289,0.8780447660402404,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023292819807663095,0.03736589752178013,0.5338860886264922,-0.050474381733408624,0.09706002134873482,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05200308279551604,0.08731086909050662,0.9464658142652354,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05095888897598115,0.035442903887974234,0.15235822195622084,-0.019011967010578668,0.12092974496254097,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.010416832597775413,0.0982113490864465,0.7692078902000675,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047491608335989755,0.03487612331052985,0.1751086955123539,-0.021360317827954806,0.11634353449993431,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014408804829123578,0.017539627335626674,0.7896200758961603,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05360886667554321,0.03586903180164405,0.1369019938221488,-0.01720324472771402,0.12442097807880044,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.01566843045415989,0.09099146061748305,0.7473242853882033,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053285639616509145,0.036616493828519024,0.14746994568827687,-0.019002100251142517,0.1255733794841608,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01658878561297271,0.057960584418964387,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059983519170364014,0.03581459074251806,0.09582711951944194,-0.01072111550017682,0.13068815384090485,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.023653584210431695,0.11706484737944545,0.6734224093863465,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07861698951824367,0.03483093532949884,0.02529002462321507,0.009854272797267943,0.1473797062392194,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.027596617402554525,0.11448782487239884,0.37388200177512143,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035907483121403364,0.054539350758987436,0.511196800553035,-0.07176329548126088,0.14357826172406762,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04455792462336167,0.12206995576261008,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06235210182738111,0.05771923497496918,0.2815723035800765,-0.05159635710400721,0.17630056075876943,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0351756291814886,0.15261641631851108,0.8768618853741261,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053753960667280935,0.039743319794425046,0.17802405400141205,-0.024706712717527606,0.13221463405208947,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.011753621512115618,0.05510482494521441,0.7948003040850444,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06771022025321466,0.057403889752420556,0.23985061617303624,-0.045615688809722096,0.18103612931615143,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008770976069087033,0.13225172912772973,0.8466912699522725,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028684080058232288,0.0352680628129242,0.41718805705528283,-0.04094160726716114,0.0983097673836257,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.08507872627877414,0.10266331905532186,0.9275420473817595,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06029134319868495,0.051096143513256774,0.2396847136141405,-0.040581906649439385,0.16116459304680927,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.00798973417428148,0.09815781415990595,0.8466912699522725,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04206834868581121,0.03794804553721588,0.2691969876878068,-0.03284812084638405,0.11698481821800646,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07004074288370062,0.09946866291235046,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05871560694227676,0.030185402271553183,0.05342445111450407,-0.0008759672107614622,0.11830718109531499,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.051599514122686735,0.041989750178868725,0.5416134009539378,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0318427300504379,0.028597699712199286,0.26709645868796594,-0.024614425221992246,0.08829988532286803,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004318244922376634,0.08148683684760788,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03459235661852921,0.032494930795226244,0.2886089620084807,-0.029558654544454756,0.09874336778151319,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.02433964798341697,0.038153199044655965,0.8780447660402404,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058236487419694005,0.033865834908526106,0.08734254053085781,-0.008620942342236482,0.1250939171816245,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014502598511743695,0.09600956589745178,0.6570209000268399,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04552976039016963,0.03195896507014435,0.15611860452587037,-0.017563155175400226,0.10862267595573949,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01232406380455494,0.06742617507253075,0.7759984237485028,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0611595478078468,0.032957232462578555,0.06524463645020391,-0.0039041324606624295,0.12622322807635603,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.028393350992126996,0.10150994822752657,0.5905495144147305,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02851874139348251,0.027636848849138567,0.30359750961688914,-0.026041516334201167,0.08307899912116619,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.009385094970884337,0.05734817336648761,0.8913059585247131,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07128271258036308,0.029158129251155736,0.015530399906622977,0.01371916561144891,0.12884625954927725,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.02287796026010921,0.07542453314970732,0.27154254286073387,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035782950327075826,0.03359155731415741,0.2882975207244008,-0.03053300466979108,0.10209890532394272,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.010365181269948464,0.09592214393106739,0.8780447660402404,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07139728595302236,0.027018811288437597,0.00900749415144554,0.01805714882524148,0.12473742308080324,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.05031133520828345,0.043059955971302195,0.19636616606057228,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047667651812271804,0.025434115297793578,0.06264430837525117,-0.002544001958324174,0.09787930558286778,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04527009961038247,0.03661719767441459,0.5816029472312793,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08671986082840644,0.032496769203857905,0.00836409743569312,0.022565220306326572,0.1508745013504863,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.027839830627376837,0.09172352328751697,0.18755425266816944,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02749373237336644,0.04137954746895263,0.507327312424644,-0.1091846222025572,0.05419715745582432,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.11805735373376072,-0.017327076833311188,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10228624919711211,0.039436847295482524,0.010333952602980255,0.02443060928120691,0.18014188911301732,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.08706148957163477,0.07528261912631301,0.2066269918449805,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06286980707861892,0.059497061764462324,0.29217130983488093,-0.054588411172994844,0.18032802533023268,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03526346348042933,0.07582339239079236,0.8799526010712531,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03206915563491229,0.042526506067886466,0.4518460039821207,-0.05188604287514184,0.11602435414496642,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05390224659924871,0.07608523316169336,0.933731420853472,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04867490371049312,0.03964073988537828,0.2212017283372037,-0.029583257936967026,0.12693306535795326,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004149852853373809,0.10043775670390916,0.8355377918591873,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07286397685298404,0.04742438672906406,0.12631557891425474,-0.020760545126327204,0.16648849883229527,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04197294070665531,0.21462322086852426,0.7263564310373228,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11264709301362089,0.040402666936817586,0.005913158601061441,0.03288474626448196,0.19240943976275982,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.11288435138634059,0.052866331089112976,0.14734065795407886,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021885897363342233,0.0604620627186614,0.7178238506693038,-0.14124920620816966,0.09747741148148521,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.16812981451073167,0.19562816548901565,0.963305304214035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08752921613288417,0.04261795972150964,0.04154368632287755,0.0033934711741717277,0.17166496109159662,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03716985773596558,0.11277399198743186,0.49032550277088105,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028071676942200852,0.03919832697556525,0.4748962304180502,-0.04931307969033823,0.10545643357473992,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03734433424273603,0.11397644374816757,0.937664825139976,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08449324833632414,0.02818006657281333,0.0031270627083472293,0.028860578222998146,0.14012591844965014,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0636450268495391,0.0429919825264728,0.09026408646858294,0.862626369566384 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07305229542354107,0.03453086227132877,0.03585598497267568,0.00488197849026413,0.141222612356818,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.025298990508936744,0.05021289035635856,0.45322421769601834,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06591466852976392,0.038753632551961605,0.09081869160911961,-0.010592178957115256,0.1424215160166431,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.030403228870171002,0.08632717156597633,0.6643433245175604,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009134939812805045,0.05341084506038966,0.8644047733767326,-0.09630795955157283,0.11457783917718291,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.10582007486578791,0.12749098673304002,0.9854445582989166,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07521012255306746,0.041742903544855305,0.07337833754674393,-0.007198099460280313,0.1576183445664152,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.016852872057297404,0.056802547040245795,0.6234452489529284,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031818664214678875,0.037339479397207685,0.3953465483340871,-0.04189638305608429,0.10553371148544205,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.035390551960152804,0.07582575374918164,0.920957044807631,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03452762685445928,0.043426648324057536,0.427689240640453,-0.05120461916764516,0.12025987287656373,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.02547926859185464,0.07434387906410345,0.9299900056018157,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051140368797670116,0.03952136025934289,0.1974438393726775,-0.026882115359947403,0.12916285295528762,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.016562986789779664,0.06251573523600534,0.8150559640549688,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04984851202223269,0.03685437687807288,0.17800736301699951,-0.022908853039070885,0.12260587708353626,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.011457482808970925,0.06666446862939492,0.7948003040850444,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034800253302732516,0.03508720907674627,0.3227108975136145,-0.034468395254936494,0.10406890186040152,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008130192410640136,0.06023897372588842,0.9034998483867911,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05485436098701605,0.031105604886205212,0.07963608949254249,-0.006553863540714508,0.11626258551474661,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.003542029892037979,0.12232550630672949,0.6378354016929029,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030913511403586683,0.03294118848529129,0.3493627126371467,-0.03411849508255507,0.09594551788972844,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.01264257862526798,0.10979441217777634,0.9086977961712401,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03886745581656799,0.032101454714183186,0.2276843968606575,-0.024506760694153834,0.10224167232728981,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0032310167470730173,0.068138829535259,0.842940686827401,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08024810540248813,0.06444424329333473,0.2147801251771965,-0.046976765361296094,0.20747297616627236,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03304780443211596,0.1646931129563136,0.8289622204693651,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043715214118681206,0.03311758798110119,0.18863078662237553,-0.02166503763981263,0.10909546587717504,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.010750974000502489,0.05364345577091717,0.8085168201280608,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06970560977232007,0.04703894896396673,0.14024812767061295,-0.023157986679030768,0.1625692062236709,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.001802417489077265,0.1640242527147687,0.7568502146876953,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0471581744837522,0.03336456468217457,0.15938218907543666,-0.018709655020556784,0.11302600398806119,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01736713029383456,0.07394152280013233,0.7804909419375794,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051720559839775526,0.03288936831999898,0.11770175005248078,-0.013209144043443838,0.11665026372299489,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.006921005016977208,0.12036033619819961,0.7176009922554474,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040753283865991634,0.03619579578020225,0.2618085482127935,-0.030703920144732465,0.11221048787671573,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0070233832583725874,0.07188190969017598,0.8669652730965864,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04267736669838468,0.02998051931946892,0.1564448221853384,-0.016509730564732192,0.10186446396150155,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014696202845084489,0.06156574021508007,0.7769533851405084,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06462447159192398,0.03824959202240061,0.0929696130322105,-0.010887306545762615,0.14013624972961058,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0010957407271590138,0.11856425004446304,0.6696849258164128,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02675248941477329,0.025676027969446732,0.298943620198048,-0.023936744769748934,0.07744172359929552,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.019668416112286844,0.049711774029442,0.8861144350754685,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06020620899355679,0.031015470706583722,0.053911451652560144,-0.0010240739715496675,0.12143649195866324,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.013096915383992262,0.08039390106534157,0.5431638761740712,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024822346780281335,0.02660685510863702,0.3521947037653087,-0.027704512557939542,0.07734920611850221,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0024309724828678416,0.05502472311119392,0.9090812501778921,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0434715384886657,0.03201812965926609,0.17637455866456261,-0.01973817893258805,0.10668125590991945,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.008705665423039625,0.08389193654197492,0.7917994815735138,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03401087188190067,0.03147021238382684,0.2813652262561005,-0.028117155368212333,0.09613889913201368,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.016287233553508616,0.07392616286282398,0.8768618853741261,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040771953284438014,0.06032928597880016,0.500081907203731,-0.07832922968682782,0.15987313625570385,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.012769386626672012,0.11335736361886596,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058084512687876275,0.043255115327336294,0.18113663023079177,-0.027309095432309596,0.14347812080806216,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06758508613057045,0.12900503148102047,0.8014130815101496,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04646936070253699,0.04290537030189781,0.2803310016599108,-0.038233785967754105,0.1311725073728281,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.030178563144748274,0.1308268930666293,0.876035315676277,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0548465313837013,0.031772795694554386,0.0861479725875473,-0.00787885135753548,0.11757191412493807,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.049242778491329214,0.023000070561201763,0.6550216536397994,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0741514902662029,0.04797849730939606,0.12410336682984438,-0.02056694861505258,0.16886992914745835,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.005774568426237365,0.13525994906214625,0.7259506085296737,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057393268707474576,0.034264507785280826,0.0957933712637119,-0.010251215143853395,0.12503775255880256,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0071890577751158,0.10197153661674453,0.6734224093863465,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07611954800970455,0.03887133058569372,0.051857422512302714,-0.0006196571923946098,0.1528587532118037,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.010336295802993636,0.09603663706742314,0.5339911008653665,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031181658627226945,0.036330939992784465,0.39196769856312286,-0.04054234508664494,0.10290566234109882,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03337126555852379,0.09666888023132297,0.9200851777021611,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07917648751243331,0.04601073862161064,0.08712342126822115,-0.011657231307663399,0.17001020633253,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.029719757913442946,0.15965935977739718,0.6570209000268399,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0212176192365953,0.03080501158703699,0.49191704948176074,-0.0395971784513621,0.0820324169245527,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.017215977006853976,0.029800906098011098,0.9421219642690486,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08081177387406767,0.032783382984816895,0.014706078415053997,0.01609130467004255,0.1455322430780928,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04609343992706552,0.02059698813895542,0.264709411470972,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06391350841335497,0.04397203391051023,0.1479494455802549,-0.0228954297569844,0.15072244658369433,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.013744331285187558,0.13013000664014512,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05538848677936768,0.03806542481777309,0.14751126681411914,-0.019759711190250023,0.1305366847489854,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03005689621511605,0.11666099626208813,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0366725404560132,0.0332260461982138,0.2712892611891908,-0.02892182790856157,0.10226690882058798,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.005096761574861922,0.04506579992234474,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0533888085769919,0.032114916301862424,0.09829118055253809,-0.01001198360077548,0.11678960075475928,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.039953605896150816,0.063119843104613,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06052256648563724,0.029994916865672107,0.04520762315053264,0.001307045800017316,0.11973808717125717,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0555584541619676,0.0331940384613486,0.5090185993885504,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05839885162771437,0.032445511172673344,0.07366986327737844,-0.005654596048274049,0.12245229930370279,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.025244258663694407,0.04436160113197871,0.6234452489529284,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09522595475958544,0.043505936795179175,0.029990836276219277,0.009337178611964703,0.18111473090720617,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.08160453953293896,-0.025433194029132942,0.4125949018381779,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03895799959540438,0.03548268663616695,0.27380008946244133,-0.031091394903500262,0.10900739409430901,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.018121721140163166,0.07060035272468257,0.870270919138952,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0866006975077879,0.04224239656401022,0.04190974244062781,0.0032063837729477684,0.16999501124262803,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04699782178753058,-0.006261051320837262,0.4906777809641646,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07383522833341094,0.033128526533172276,0.027157057874695283,0.008433381847405871,0.139237074819416,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.031430881620966716,0.04917504430102529,0.3910019750822703,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08693128845475684,0.04553927843001125,0.05797591011568404,-0.00297168063687335,0.17683425754638704,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03069376671855423,-0.0052693891587204745,0.5639862432577204,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0382362308157653,0.024180863694944682,0.11569946313297404,-0.009501272199716651,0.08597373383124725,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.023777279827953694,0.03956633905235755,0.7154246045700844,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06270297337756625,0.027814290859105424,0.025466632855533626,0.007792412261520276,0.11761353449361223,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.031479171525661716,0.05005397108422965,0.3742940281840044,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04070725597925416,0.03114631214385214,0.19300944868058836,-0.020781332213694798,0.10219584417220312,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.005799993832484758,0.06930704142234204,0.8140390093255331,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05380707287826203,0.03244093851860419,0.09905895746518312,-0.010237347531778865,0.11785149328830292,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.009964028026830234,0.0959594951270996,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018481404129633523,0.05042662635959049,0.7144524992825458,-0.08107009486851009,0.11803290312777713,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0261993098593521,0.09193390242025784,0.963305304214035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02671048095233331,0.04447090752818273,0.5488970781441853,-0.06108332612626446,0.11450428803093107,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07520230325584266,0.130877095388005,0.9485922053772787,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04177710370880972,0.02683434033500856,0.1213873766288884,-0.01119885359451648,0.09475306101213593,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.023070313994285302,0.036918211835394524,0.7228579124835106,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020743251700822054,0.03637111037890361,0.5692211491235174,-0.05106005579444853,0.09254655919609264,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03737460655412278,0.0865581310466185,0.9525219182038099,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03125396588027754,0.0328746653127373,0.3431220501414799,-0.03364671154374062,0.0961546433042957,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.045466463785921556,0.11681547955808635,0.9046447408422388,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04090010098165165,0.0398365640905048,0.30603890795166466,-0.03774465391163561,0.1195448558749389,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.018758029459376428,0.10459727315620901,0.8944539216937829,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04279395132677278,0.035972756100522155,0.2358738624123691,-0.02822293105129075,0.1138108337048363,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.020469698431153625,0.09505945062583161,0.8449482942840995,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025038902906762615,0.0392767654887538,0.5246676536873713,-0.052500705876928164,0.10257851169045339,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.01757230952207025,0.09746713773189315,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05216667383721277,0.038438387393514795,0.17655392824201555,-0.023717821326282834,0.12805116900070837,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03782654361939794,0.022658127569193276,0.7917994815735138,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033434900093834805,0.051725431954430336,0.5189076399319614,-0.06868068167580858,0.13555048186347818,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06869943936775308,0.1775949997319343,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02870196895161535,0.04713540587138733,0.5433960767311004,-0.06435205129794819,0.12175598920117889,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.09285682262592386,0.11626743380361353,0.9485922053772787,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09571551718828242,0.05567167051004075,0.08740414089548286,-0.01419067029854415,0.20562170467510898,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.006971291163192192,0.1625565262907414,0.6570209000268399,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04588553947545563,0.047811514179731784,0.33857666878083126,-0.04850324378404678,0.14027432273495805,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03751222129860061,0.0871950310164386,0.9034998483867911,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056504700392524816,0.04407090545651041,0.20156291552803415,-0.030499428519753007,0.14350882930480263,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.04024926839022429,0.1423975778129697,0.8177134279159035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0415014187629264,0.03332585979448631,0.21474762745853612,-0.02429000012528376,0.10729283765113656,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.023382784421980825,0.08552614937739661,0.8289622204693651,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0371843648107043,0.030654829211973395,0.22683193318346848,-0.023333945056432645,0.09770267467784124,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.044656029680555674,-0.04193977805450193,0.842579263271115,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07442566926024252,0.03503707304529951,0.035116923661156096,0.005255998513398127,0.1435953400070869,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.06944854458790259,0.12237613931124432,0.4493241481738629,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03831938408255113,0.03758103502258049,0.3093620752786582,-0.03587253872665906,0.11251130689176132,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05714446161594353,0.08913500531264874,0.8972291390434742,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06266425144391313,0.05681096873692715,0.2715913026845183,-0.049491121730722135,0.17481962461854839,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07173207396829624,0.2035947086401911,0.870012817074135,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025147053733786173,0.030135402759626326,0.4052018628199625,-0.03434581212324193,0.08463991959081427,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.051548366318811156,-0.05608073874264109,0.9237532919369174,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04964316971990826,0.028974191557458714,0.08849127274915011,-0.0075572501780172,0.10684358961783372,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.039896936497020453,0.037621840270309695,0.6595715709697217,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0007388044536793675,0.03775826811452118,0.984412252710475,-0.07528061820837845,0.07380300930101971,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06814392121429272,0.08192925937408185,0.998871063691614,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048878531820962384,0.03355347705059048,0.14705595477894223,-0.017362245683496064,0.11511930932542083,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.03552709242323638,0.04985932180069042,0.7662201971017615,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0033341660384875304,0.035005091562896176,0.9242313348424815,-0.07244069941638064,0.06577236733940557,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06747996778497307,0.07333852346799571,0.9915432628301946,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04913925708360783,0.02553227495862387,0.05596999614363921,-0.0012661820357664222,0.09954469620298208,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0446436062236304,0.059847300526655656,0.5518846108576955,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04783276862518944,0.029608105288434355,0.1080724851268895,-0.010619114372887054,0.10628465162326593,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004421554062351099,0.09661533724756638,0.6968963338239227,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06627761300155934,0.05149084811175125,0.199804671329854,-0.035374856819786804,0.16793008282290547,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.012057397629343195,0.14955363630005403,0.8150559640549688,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060640321317441945,0.042970675480299036,0.1600341452064767,-0.024191749868953463,0.14547239250383737,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.004504166748419373,0.10261567849372742,0.7815068115919459,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05105162057780942,0.031051875620236292,0.10203068372007176,-0.010250532428714598,0.11235377358433343,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.004075600933347266,0.05002886560365675,0.6834764281602781,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052194626454596396,0.0533172041317512,0.32901460399520643,-0.05306340837517905,0.15745266128437185,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05606186714544462,0.13929968021511685,0.9034998483867911,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035913059739855695,0.03990982982953319,0.36948545721555726,-0.04287633529043918,0.11470245477015056,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03395556010878438,0.10216907879936935,0.9150244079451123,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08555707657150743,0.03855665427853558,0.027826597636662148,0.00943910067500181,0.16167505246801306,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.05183896411550754,0.054602028684983824,0.394442021499686,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029556464572504743,0.044708904835083364,0.5094622559407739,-0.058707193264906934,0.11782012240991642,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.06473962040924938,0.14745909835882948,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04548471900661701,0.045169747564549494,0.31539585931260056,-0.04368872772275024,0.13465816573598427,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.03406566184899592,0.03639431895980652,0.9025176929330414,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049577695619770025,0.04438286331381014,0.26556968433882394,-0.038042295874648004,0.13719768711418806,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.043613380503326846,0.08978529207994233,0.8693121373799397,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004177114340644038,0.04962126936207692,0.933013611254778,-0.10213868948071714,0.09378446079942906,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.09921306069100164,0.09042977854263089,0.9919986667747693,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03954183812062764,0.047202866236317496,0.4033894089678447,-0.05364536138236979,0.1327290376236251,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07223653018145892,0.14730208068614592,0.9235345118679857,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016321100317063436,0.03956630505902044,0.6804989053954207,-0.09443231383262302,0.061790113198496144,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.047202014411801586,0.010247124715451328,0.9621831471002781,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03109345509622783,0.08043480986252234,0.6995658564762048,-0.1276997553863501,0.18988666557880574,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0629499396893332,0.1035942602055031,0.963305304214035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007448381775819776,0.03813651871358617,0.8453875462614135,-0.06784016871009241,0.08273693226173195,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07027517554640828,0.12757845659657538,0.9824089645441008,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0064949571389821175,0.033561816835508206,0.8467837870482877,-0.059762284645358175,0.07275219892332241,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05959375983986573,0.12016695500040125,0.9824089645441008,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04706647362293903,0.03858035721981187,0.22419001448891623,-0.02909829626922067,0.12323124351509873,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0025506841052593153,0.032705988073321486,0.8362877514158915,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02108345744518785,0.034014815787466846,0.5362084408254251,-0.04606808816171014,0.08823500305208583,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0470810461331702,0.10449380898080267,0.9471273828544232,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07771494381376519,0.03613867754755955,0.03294823408984226,0.006370501772068285,0.14905938585546208,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.045474952717515144,0.04349535514889311,0.43476822754237954,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06361989532223024,0.037697169142124606,0.09333271870486527,-0.010801297745969773,0.13804108839043025,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.022098594486277087,0.03936938457227199,0.6704521782043941,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05100437519729668,0.03472654712955811,0.14377244850856663,-0.01755225988522654,0.11956101027981988,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.007849533539092934,0.09219208527053592,0.7626680424539931,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041604351413838454,0.029863357912558307,0.16541287469552052,-0.017351447534782613,0.10056015036245952,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.037522742258974666,0.06846462394837662,0.7824698350312412,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05271123105925434,0.03807914205944244,0.16811648378701666,-0.022464047285730253,0.12788650940423893,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.014790932051580337,0.10568749651931225,0.7842677313995,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04233256624184013,0.037914220845977786,0.2657874221996868,-0.03251712708581807,0.11718225956949833,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0033894408706057286,0.02362512858758424,0.8693121373799397,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03854228980664315,0.06078143498952181,0.526869635411163,-0.08145151904577698,0.15853609865906326,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07307707997825226,0.16191506402928396,0.9448126253726593,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0604734887609555,0.0408390064427702,0.1405388279729986,-0.02015027297914347,0.14109725050105448,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.0038996054629033576,0.07583305004904649,0.7568502146876953,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025988733389003024,0.046754893231558924,0.5790525292718385,-0.06631408444197052,0.11829155121997657,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.07649237791292647,0.10613327784153868,0.9525219182038099,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03637431939799211,0.054279793860922916,0.5036973382929408,-0.07078404582025549,0.14353268461623972,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.05810383550532169,0.13235046684386692,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05197064051974433,0.030872799650643108,0.0941589360556085,-0.008977983359520172,0.11291926439900883,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.007944748072794104,0.10448537867963288,0.6707240267079618,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1152829951122663,0.048651398469591656,0.018943610587396294,0.019236124725453232,0.2113298654990794,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0865304874146947,-0.005544190427376137,0.3146632024742357,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07435267003863204,0.05455516152597972,0.17474123506571423,-0.03334932194608892,0.182054662023353,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.019567200724359798,0.14767062621478003,0.7896200758961603,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03918347163489627,0.025399602025015473,0.12478983961216415,-0.010960046543683474,0.08932698981347602,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.041549804246522715,0.06290078809982963,0.7261583573371491,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06755690048642699,0.03145379403961432,0.03316169032721889,0.005461286088321353,0.1296525148845326,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.07893226097079895,0.05354252541556454,0.43476822754237954,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056291313903294886,0.030826860758672792,0.06961841938933273,-0.004566618095744539,0.1171492459023343,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.027143206481286798,0.0590568356916745,0.6099680056429616,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08559336371484205,0.037963778662574714,0.02544979813551785,0.01064583407955308,0.16054089335013103,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.09369925184658273,0.056269276417606554,0.3742940281840044,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07488186078940574,0.03274404252808331,0.02345043937866991,0.010239056932476676,0.1395246646463348,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.06848037207089491,0.044259682543384055,0.36184220356199315,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.046952721455408054,0.028366690532348686,0.09974956281391531,-0.009048378915144144,0.10295382182596025,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.05115288177876216,0.05627018292196654,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04954371059740454,0.02739060331063558,0.07227245632609695,-0.004530412834782782,0.10361783402959186,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.022683511393751493,0.06550054009837487,0.6222329265906265,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059684351997133005,0.03025237294059975,0.050149740088091546,-3.943465897754406e-05,0.11940813865324355,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.052532712846205094,0.06406629242423749,0.5271148591877783,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04729195753462142,0.026894177203345658,0.08049252217774455,-0.005802128828059944,0.10038604389730278,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.01824224147340315,0.04915733092796059,0.6389496410469363,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0556110624424624,0.03015043519573747,0.0668781254554361,-0.003911480227323051,0.11513360511224785,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04553327286207449,0.07507744072820127,0.5974084401217474,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05112448051825952,0.024217958584970972,0.03625089930637499,0.0033137453202207803,0.09893521571629826,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.035626383385456074,0.03482612240845559,0.45679694638302454,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027702539465775118,0.029830775634360256,0.35439955068422924,-0.031188936031733824,0.08659401496328406,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0370243568050921,0.04260723096054261,0.9094475823584263,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08636569492450848,0.037394032691633806,0.022126564811215922,0.012542949347761484,0.16018844050125547,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.036415779390101266,0.09134018053945879,0.34668618042031035,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05266367186175975,0.032136034860663666,0.10313190486141895,-0.01077881226205122,0.11610615598557072,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.0580365973762895,0.022957890603774008,0.6839484127328216,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0438442781812996,0.02834458035609345,0.1237856598211501,-0.012113172606716065,0.09980172896931527,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.034504466843343434,0.04255689563934123,0.7255813269452924,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07039521503133657,0.031932138768849296,0.028846319862121217,0.0073552595525164105,0.13343517051015674,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.07442389033652265,0.05938641112774028,0.4046097093301284,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04242941750086695,0.029973419759699672,0.15875313086117804,-0.016743663916489876,0.10160249891822377,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.02190027523110968,0.040971420482348836,0.7804909419375794,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04773047609412445,0.028700411953777177,0.0981650844271068,-0.008929452164577335,0.10439040435282623,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.020204740901694548,0.056648954198612794,0.6779844217208436,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05698475001011893,0.028133248915556373,0.04439552632837039,0.0014445066224333877,0.11252499339780447,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.04249193159604222,0.057134232238998016,0.5034452685637203,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02812458638644101,0.043509539601143093,0.5189021099609903,-0.057771302367360236,0.11402047514024226,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,0.039171350888505214,0.10365581627281713,0.9438759903131516,1.0 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06978589301475754,0.03517389371298107,0.04888179799485022,0.0003461129319346362,0.13922567309758044,58,121,179,9,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid|lin_Prostate|lin_Skin|lin_Soft Tissue|lin_Uterus,False,168,-0.06820247986293583,-0.005114580406953241,0.5231588877093131,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1259979453158783,0.18499408020722352,0.4975817353029488,-0.49357724222238797,0.24158135159063135,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06880091429239364,0.13901802830663648,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11555205626240837,0.1804324903701839,0.5235468825687253,-0.47406757132683597,0.2429634588020192,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.07774364668487871,0.07560003848770104,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033985655390897936,0.11516784411474433,0.7686072801718926,-0.19485039773315888,0.26282170851495473,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03041118863648724,0.10734608963079265,0.9691554932400821,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2231157617685641,0.1903267700812413,0.24421409682468623,-0.6012909998658199,0.1550594763286917,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0003989617334481464,0.17407386381532994,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00017122875015466025,0.14497017197882503,0.9990602375472089,-0.28822387253584236,0.287881415035533,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02225162326207835,0.16430030742323642,0.9996899238181953,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01675199815231401,0.10917413919229098,0.8783963822165389,-0.20017469095970203,0.23367868726433005,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012768280031735225,0.0632054830503486,0.986191362849829,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12692610770614343,0.17294788586025564,0.46493990271553365,-0.47056987303511494,0.21671765762282807,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03402381519742501,0.10683546512836892,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03906319441719934,0.10665447379605456,0.7150408080667887,-0.17285697322261184,0.25098336205701055,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.033058272160767045,0.1217609296172673,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.040334861999312376,0.13797523884183097,0.7707116208936851,-0.31448872263732214,0.2338189986386974,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.008520840368722964,0.06485872905616896,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16262192179958207,0.19745914003154785,0.4123839655627306,-0.5549690270650957,0.22972518346593152,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03214630403215349,0.16294362197012502,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.061060667461975186,0.12351404185307926,0.6222684888296595,-0.306480437713971,0.1843591027900206,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06615434009394489,0.19733838965482747,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.22411886006851084,0.17442332829395693,0.20215659113794435,-0.5706942980855945,0.12245657794857284,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.02998720025024335,0.07278537503406342,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08355417011869369,0.14272132871120033,0.5597362705809525,-0.36713841023308297,0.20003006999569556,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.022554272967220654,0.160213181255195,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022397253063119175,0.14081557566981975,0.8739868637625127,-0.3021948024777659,0.25740029635152756,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012470445200963099,0.12324500614813723,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07873863896184415,0.23918320812030586,0.742779459751056,-0.39651330085278136,0.5539905787764696,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.1051696088527,-0.07518159507655561,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16852306078509793,0.14888055029194808,0.2607024956759883,-0.12729942141577655,0.4643455429859724,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12697514382737343,-0.086973056752792,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04562658777287492,0.11884273503101463,0.7019504043818853,-0.2817645708705699,0.19051139532482006,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.056791088014925724,0.011420455063883967,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060740752348048245,0.1418170699388611,0.6694648991017254,-0.3425282495429578,0.2210467448468613,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.057413306767561775,0.21735248918331423,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05572533355253082,0.1367526188933147,0.6846265866451018,-0.32744987439524736,0.2159992072901857,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.007959982542654979,0.12753544836109312,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054008416025378446,0.12890546350885992,0.6762424432266063,-0.3101408262674673,0.20212399421671043,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.042684540884394,0.16889195597104983,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003367958187228598,0.2199980094382331,0.9878198974644288,-0.4404993168747796,0.43376340050032236,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.08500525629959611,0.18081115415515742,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12013909109639413,0.15518834582628238,0.44089361795639537,-0.4284950286648317,0.1882168464720434,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.009353833110319633,0.14408002029258044,0.9320838159679753,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04114634525768989,0.12061903942765449,0.733812406281914,-0.19852111683996787,0.28081380735534767,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0891961585877037,0.03781296689808815,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.23971190996239555,0.1867855310970796,0.2026997740023105,-0.6108507816282608,0.13142696170346968,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.019216574413819007,0.02185631415908266,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05393522264786692,0.16367360602634806,0.7425300594761575,-0.3791511914936034,0.2712807461978695,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012742210824478633,0.10867038729287193,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04687400794075379,0.10634926184321805,0.6604588660408535,-0.16443971004993657,0.2581877259314441,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08649016108878134,0.27078099183612714,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017439085679995123,0.13439655241080356,0.8970503686923141,-0.2844821726073413,0.24960400124735105,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.07967120404530324,0.03996642607302691,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06239751802841704,0.09312056512700546,0.5045465711969708,-0.12263106136493024,0.2474260974217643,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.16380807654330148,0.32791141095626275,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00794603747495716,0.1675275079644248,0.9622758037293375,-0.34081962738163807,0.3249275524317238,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03615480936613008,0.12879379118281284,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0503019726643411,0.1085448977151213,0.6441940236833629,-0.2659783723643751,0.1653744270356929,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07903497602263687,0.1804499841792256,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03623206123662941,0.12439992819295087,0.7715342570428092,-0.2834120687761337,0.21094794630287483,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.010077764640726291,0.12998900175199526,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09649720784636595,0.1887075563137824,0.6103663975701096,-0.47145510267773355,0.27846068698500165,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10462507429896267,0.07471049736897986,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1961997954168615,0.159045133108999,0.22059592446423196,-0.5122190871645838,0.1198194963308607,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04265357338829206,0.023906446028946905,0.8354439162199777,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012667101303326784,0.14692686208661115,0.9314902414787866,-0.3046076466547201,0.2792734440480666,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0036280896422349884,0.12493559747549492,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09683625000083355,0.2088306355043206,0.6439897124069044,-0.5117782745522786,0.31810577455061156,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.09261465508469519,0.076000794886664,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045583650007204705,0.14954346289551051,0.7612158764700054,-0.25155602541658256,0.342723325430992,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.18780573944835757,0.24283128161648757,0.9680441569078666,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05906253741964086,0.16538511918798718,0.721846443209058,-0.3876792464614789,0.2695541716221972,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.009430934629945507,0.06988869828784701,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07088477650498078,0.09383141811212882,0.45197478903040156,-0.11555625262828705,0.2573258056382486,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.3322791723006225,0.3179942699278072,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027031002370493808,0.09868531490778745,0.7847876540319806,-0.16905461630534951,0.22311662104633712,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04296733518336648,0.04959828519132685,0.9721878388985049,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0052511438045314916,0.0998461887082165,0.9581745942703954,-0.19314110638557927,0.20364339399464224,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.011644342071577662,0.11613480228016945,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05133079233763807,0.11958273673019822,0.6687792188827921,-0.18627755837393317,0.2889391430492093,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04960870062857282,0.09558632460424477,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05778510467973851,0.09984076434245219,0.5642044592137302,-0.2561665767706172,0.1405963674111402,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.013075316632703882,0.0705881006871217,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014735965483367443,0.11806113557007418,0.9009503992096302,-0.21984899613389328,0.24932092710062817,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.015040788492321423,0.0980453432323715,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007889880376283602,0.12279566475215911,0.948913581711271,-0.23610248987797078,0.251882250630538,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.012224182421593628,0.13606429469898296,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04057275525395164,0.10551578316703818,0.7015115539438906,-0.1690848583606766,0.2502303688685799,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.027398779026163687,0.13997534068402534,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007967027133299559,0.12235319972946036,0.9482284854876203,-0.23514617454557585,0.25108022881217495,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.015388730383658188,0.09221584461942764,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020367843683866783,0.16208553914477103,0.9002836389403468,-0.3424283574625183,0.30169267009478473,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.032707855566359696,0.08553683001730131,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015485085470615093,0.09133054589377236,0.8657489102174081,-0.16598676383459143,0.1969569347758216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01773027289834427,0.0444458451123485,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045175378179503574,0.10228789618740905,0.6598142084666203,-0.15806849276218796,0.2484192491211951,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.020899493362804465,0.056659825131092335,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014831067840738933,0.13760471557750067,0.914412630511838,-0.258586570963375,0.2882487066448529,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.006162944475070694,0.15189036244607912,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07204275555616821,0.07126965018974926,0.31482968609039297,-0.06956852129212734,0.21365403240446376,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.20182598935605833,-0.0962694064477612,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050158871454846654,0.09068587730881623,0.5815777720689359,-0.1300320351038112,0.2303497780135045,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.20508100611087154,0.25831756965149755,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03407075315057603,0.17806404042879273,0.84869515342768,-0.38788020863061246,0.31973870232946044,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12382028268517913,0.10154300843712809,0.9827611894425448,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06103878358094403,0.243534849613044,0.8026726688519901,-0.42285977518763984,0.544937342349528,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.17201173581370666,0.3466577597535442,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034684334122250096,0.1664244754059773,0.8353859573060045,-0.3653662218304339,0.2959975535859337,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.033391171490676205,0.18000414752365765,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021714288334011546,0.18028842516119667,0.9044045531245151,-0.3799435488968416,0.3365149722288185,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.015434167845637775,0.22299460083101746,0.988603595072994,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.052320243565332596,0.13982387426888757,0.7091553765677818,-0.33014730342005655,0.22550681628939134,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06558273449385783,0.023485907626485555,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17294019145998904,0.24723167065327514,0.48605972256478025,-0.6641842548913989,0.31830387197142074,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.1010653326144649,0.2646422926851143,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11299803750691778,0.141449395093776,0.42649924694994457,-0.3940549726162989,0.16805889760246334,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04804083128727381,0.03150743090252696,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05300825136663663,0.16211385816894286,0.7444495755547227,-0.3751250344431084,0.2691085317098352,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01952398802849892,0.1423871704717342,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0648708918436478,0.09420723244787514,0.4928675068324234,-0.12231687236971706,0.25205865605701266,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0259479151451548,0.08043787939642827,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07063689858521653,0.12405076761537558,0.5705060257307899,-0.3171231314943714,0.1758493343239383,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.09341146276219185,-0.0058007614232431365,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039160376059483804,0.14403725104088516,0.7863465006530437,-0.3253593258131615,0.2470385736941939,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06772008579137605,0.04469940681991056,0.9723925976809099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09680941397423908,0.22470711860910575,0.6676373363738374,-0.5432976722779637,0.3496788443294855,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.007147122340316978,0.17554551039502486,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007320738017456259,0.14709337672250763,0.9604177357920864,-0.28495066836861943,0.29959214440353193,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01749634216309244,0.05027590828510024,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02027145786993702,0.13055329844637983,0.8769573812720297,-0.2796780810331802,0.23913516529330617,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.005774153506515293,0.10876219998321598,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01902837024911489,0.18387943493103284,0.9178125786629414,-0.38439289073432836,0.34633615023609854,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03860389951287801,0.08540404950580065,0.9901412236863718,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024356983205649555,0.10117689533454712,0.8103129526200105,-0.176679352706272,0.2253933191175711,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.12403834850233432,0.21234008691220924,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06151215093237865,0.12840483973470346,0.6330790294304529,-0.19362553053399484,0.31664983239875216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.011351377704749433,0.11616529540838931,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007402390991282722,0.08225446422390012,0.9284943698975501,-0.15603547736090825,0.17084025934347372,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.009310529120670173,0.07608774638038815,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003312937934933034,0.10762229424876796,0.9755115184040888,-0.21053026832936622,0.2171561441992323,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08091544839331691,0.18025637794252325,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012825423841409677,0.13627747271339358,0.9252312856276725,-0.2836058593454711,0.2579550116626518,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07523733374447635,0.1675605356447373,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.000934508361144892,0.11009369497946245,0.9932463954312238,-0.21781931851298858,0.21968833523527836,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.014693226902019548,0.10462081393750275,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18219016768026816,0.1754341718727919,0.301845838466627,-0.5307741303570296,0.1663937949964933,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.061180902553067545,0.15268796443654123,0.8900639917340583,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022039904225106467,0.10033292015775135,0.8266329849821313,-0.17731947098760983,0.22139927943782275,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.008994939779012105,0.05739569585966422,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18892506002155188,0.14963683461609348,0.2100465151173045,-0.48625026306527375,0.10840014302217002,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.012215318852102548,0.06720075346240707,0.8250119925785071,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04527297087822049,0.11791370811572159,0.7019312450457624,-0.2795649972839602,0.18901905552751921,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0069812826933754206,0.04687170338939118,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05376144658438288,0.11038080830681812,0.6274172832856995,-0.27308576152431646,0.16556286835555067,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04042062206721172,0.14495671934132387,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009957531620330464,0.11506242421142975,0.931231358457324,-0.21866905440133622,0.23858411764199716,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03549575068896218,0.08481378703010242,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011720600292573814,0.1289055811758024,0.992765771173012,-0.25496058401453975,0.25730470407305456,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0009988751702519364,0.10090620515246507,0.999521629637202,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06162546563890389,0.1272378726515536,0.6293395230518831,-0.31444440836803367,0.19119347709022586,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02566010794876248,0.1609806585992016,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02224909589061136,0.08947872885735889,0.8042025933519988,-0.15554323240785875,0.20004142418908147,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05659444368341042,-0.037350195273459376,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015903089894911487,0.12958862802543994,0.9026056828247866,-0.2733929334797034,0.2415867536898804,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0018434675678515708,0.11983305408160475,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006825944260124229,0.09323173672253542,0.9417994736904383,-0.1784235307255312,0.19207541924577964,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.017247689130748776,0.014032370263056631,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0483980933185717,0.11189994058566213,0.6664153798870527,-0.17394470510115737,0.27074089173830074,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.01891966507977359,0.18096573673778416,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048214511645971875,0.13129359339705593,0.7143216855459552,-0.21266306181561676,0.3090920851075605,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0714172177288459,0.20996570396107422,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05330530615015735,0.2316845918244242,0.8185598944857677,-0.5136576551090953,0.4070470428087806,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.08130534147289929,0.06474784921306302,0.9782788982878687,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08582984987481199,0.18192087805368987,0.638225845350618,-0.4473027595629734,0.27564305981334947,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04034368226193161,0.20467115807907676,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04251703261410027,0.16326373871791833,0.7951419046119057,-0.3669186038483629,0.28188453862016233,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0203008465933069,0.17913808389276129,0.9735235918682278,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03393051445059297,0.0827211276731315,0.6826599704954397,-0.19829563313624485,0.1304346042350589,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03969749095654931,-0.00867555166141737,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09661087288282356,0.18206754642253298,0.5969953898259461,-0.4583752094957676,0.2651534637301205,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05590280572143156,0.12056893974580633,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042091804383735616,0.13904687983566993,0.762812202231133,-0.3183749928500212,0.23419138408254997,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.00851055874790444,0.08958902941958895,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041193210985358164,0.14330211179648863,0.774430592900786,-0.32593145471924884,0.2435450327485325,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.002274653020090908,0.17928584694459185,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09719189254146783,0.16065535134326706,0.5467374142211774,-0.2220268685393016,0.4164106536222372,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.05194484170792466,0.2504467090306285,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09540361524189545,0.17873547695694145,0.5948313979562296,-0.45054720080143384,0.25973997031764295,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02744830258977056,0.20643113329195187,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11169958101393763,0.06160613887828812,0.07318365438901928,-0.010710504696046633,0.23410966672392192,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.17831015004569878,0.2580259948495923,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001702227177012953,0.12429711921227896,0.9891041055378986,-0.24867795546180418,0.24527350110777826,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.035771262076255736,0.1070766961474487,0.999046747647263,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03181666983299231,0.16967807699196483,0.8516860750250774,-0.3689633945892132,0.30533005492322857,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.023899725721780306,0.19039078528061862,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10825957083483746,0.17863040719587325,0.5460219060179508,-0.4631943850171711,0.2466752433474962,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.019119425335318373,0.12854582545971893,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04706067876639246,0.08896099336096086,0.5981199150255387,-0.12970292012875645,0.2238242776615414,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07432390384042264,0.14372691534401963,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06750776456483816,0.11229911046950927,0.5492731330804823,-0.15562817591157957,0.29064370504125586,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04606495611924086,0.16959590493478072,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054961721382920416,0.11195750343809431,0.6246942274863735,-0.16749545319847423,0.27741889596431507,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.02559223729057494,0.09209286882869545,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14521181605744818,0.11958090204683404,0.2278303745220148,-0.0923928891773581,0.38281652129225446,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.006129638523708999,0.14644844987924147,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043373403034735414,0.10480306511801835,0.6799750158279099,-0.16486805499773677,0.2516148610672076,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10030456239680846,-0.030922738317429428,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061757502238001666,0.11501010714485185,0.5926250865817162,-0.1667651308867541,0.29028013536275743,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02557951374645911,0.14925428503291696,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041255615801121394,0.08768322838387757,0.639143527338299,-0.1329690913015879,0.21548032290383068,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03069698513355944,0.07355175278888132,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1428561685513983,0.11470747561156272,0.21625531976657747,-0.08506514216291305,0.37077747926570964,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02787237349080994,0.12043674179264563,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0567841166136053,0.08285656613541259,0.4949166781307549,-0.10785011541169298,0.22141834863890358,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.061043873162746204,0.0525673417507669,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006459340660858698,0.09010664208738449,0.9430130333508522,-0.18549931917252788,0.17258063785081046,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05283784471860476,-0.03660058492138753,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027500471948071977,0.07552641728333086,0.716634073802108,-0.12256891044392948,0.17756985434007344,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03899323979500098,-0.02601447261021126,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06830483361841083,0.1261595862589211,0.5895735537855338,-0.18237157701659068,0.31898124425341234,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.031332526028500736,0.1440564894021493,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03798679051613569,0.1280932745887516,0.7674966853724217,-0.29250539867399433,0.21653181764172297,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.002434774735771407,0.108433842208097,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05459493903301115,0.1684192197586564,0.7465767628761311,-0.28005046321490645,0.38924034128092877,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.033123355201433294,0.27540430495656604,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13171943199155842,0.20464274358195864,0.5214540072481731,-0.5383402044974359,0.27490134051431914,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.050893845594086454,0.1341740679445958,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07819223723625568,0.09843860182030865,0.42911925547734897,-0.11740316778987783,0.27378764226238916,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.014657646515887544,0.10138128983155681,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08240214518932755,0.14749641913690853,0.577788411195822,-0.3754743882678154,0.2106700978891603,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.03288199073588377,0.13354935006979124,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02725766216589101,0.13905277599586605,0.8450383729379105,-0.24903724184511314,0.3035525661768952,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0314312206373256,0.15817548777320184,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.079906485664695,0.15198571713330974,0.6003694901320897,-0.3818988682377683,0.22208589690837832,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02036706686419848,0.15943073351799014,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011019609726060812,0.14587085993874244,0.9399517600913625,-0.3008619013030061,0.2788226818508845,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0381728734330019,0.08528974274259352,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06612375566521361,0.14990340951929468,0.6602037544383019,-0.36397863736341923,0.231731126032992,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.009775151755725749,0.09482971791387713,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06262176543915565,0.1148083013482314,0.5868110300311605,-0.1654998838662784,0.2907434147445897,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.019589164558172837,0.12992331802686635,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1320386100389752,0.23079442632088945,0.56869321596739,-0.5906222191033543,0.3265449990254039,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.008704140456683634,0.15882738026691684,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06770897095370275,0.1746133009323964,0.6991156210505274,-0.41466188055685466,0.27924393864944913,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.10030218729021287,0.23043773257849276,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18838071507263557,0.1680617348910261,0.26534506516844303,-0.522315802503176,0.14555437235790483,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06915674960850902,-0.018226326279955865,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006610636092265638,0.15915428798725734,0.9669616157102114,-0.32284681625803435,0.30962554407350307,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.034280114095822094,0.18924429720874802,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16231814563612726,0.16741962914791308,0.3349088947698481,-0.4949773826322714,0.17034109136001693,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07321904363384289,0.12744224047663705,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019339920740471542,0.14411362597516442,0.893548135655128,-0.2670107843807953,0.30569062586173834,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.023332897753720997,0.15433776704715202,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052532913889632465,0.091002874599388,0.5652168622434539,-0.12828785953319266,0.2333536873124576,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06475374876075422,0.01569079181891101,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0011840861965473053,0.08090613868293904,0.9883558893186336,-0.16194286041884834,0.15957468802575372,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.042734338556489455,-0.006199875875143668,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007533049585559912,0.10235482365031488,0.9414958933179427,-0.1958438047993375,0.21090990397045734,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03365154768028991,0.10387268128148733,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1632753336601071,0.182243337284453,0.3727126762089451,-0.525388962971254,0.19883829565103983,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.035368233201975394,0.20498493361073064,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05259164082932805,0.06052513782015268,0.3872268643673473,-0.06767051880399735,0.17285380046265345,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10715095675292337,-0.0791334673757973,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08612795501630761,0.09921434587187161,0.3876744752833202,-0.11100883691655021,0.2832647469491654,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.03577879320360579,0.12562656972763242,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046263126086582944,0.11443799335502636,0.6869886614007854,-0.2736489812972616,0.18112272912409574,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.039153434259072445,0.1557487648198988,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049256426704467116,0.11671727752468246,0.6740318424959562,-0.1826583176014401,0.28117117101037437,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.024906681744851274,0.08875306166761292,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06926369544080721,0.103935999048683,0.5068747015740449,-0.27578231166244543,0.137254920780831,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07513583990566045,0.1429323907792652,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03489753282842541,0.07713878964376696,0.6520821545010673,-0.11837559909943525,0.18817066475628608,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.013831764712340183,0.09368836880515655,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042113886530259194,0.12208600268796513,0.7309438681548508,-0.2004684003185941,0.28469617337911246,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.01934200025496992,0.14007689015181982,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11911037502913327,0.1976149205658081,0.5482145885221015,-0.5117670128980196,0.27354626283975314,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.00963631793002148,0.18187405531775497,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06141262735946377,0.19044737345040547,0.7478566741215394,-0.4398275017823375,0.3170022470634099,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.029210786905475662,0.10992385534953782,0.9635753025013546,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03070919312934658,0.08774003912795028,0.7271640877504078,-0.14362839571173827,0.20504678197043144,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.017214818968613658,0.08282131752102066,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10495632150542503,0.21070344591132828,0.6196257492007944,-0.5236195804438081,0.3137069374329581,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06242655910485705,0.14980083049570356,0.9576692362063679,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054656457586924216,0.11647679220344415,0.6400401807367125,-0.286093362681987,0.17678044750813857,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.011029599678990209,0.13710357813339877,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004447118616880831,0.13436119667247048,0.9736703655302297,-0.2714199544452539,0.2625257172114922,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.04203913370012932,0.07604842824951258,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06281658077399721,0.17343022234715877,0.7180605364316164,-0.4074187384284399,0.2817855768804455,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08725663807870859,0.2492188700742172,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08611035951298027,0.13808176721188298,0.5344731274373665,-0.36047588975317657,0.188255170727216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.18361457811990806,-0.0381319535961399,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11272550747156738,0.18403519789421127,0.5417547011085513,-0.4783995256467884,0.2529485107036536,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.08019829139948186,-0.023978128130880603,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0739877602548005,0.18577811272777733,0.6913932389754542,-0.44312491307937074,0.2951493925697698,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.017723844626968233,0.16133148344980044,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11177343482986855,0.17220134742995152,0.5179544957347773,-0.4539338441994629,0.2303869745397258,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.022510482343407343,0.13856843097330032,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029681932713821416,0.12255940088317989,0.8091947445377884,-0.27320485169295117,0.2138409862653083,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10587442940753398,0.06713073927198054,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19421213483196106,0.19806198025467758,0.32946659664279043,-0.19933280111611693,0.587757070780039,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.5384547620831803,0.664719215302393,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0038232658246355935,0.1523708525875473,0.9800378794496172,-0.2989343726924324,0.3065809043417036,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06954191110235164,0.24652522041792485,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005724883024847922,0.14580325029601293,0.968767500812882,-0.2839830696321126,0.29543283568180845,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.06579504912689521,0.21709007300997696,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020474081150738645,0.1306993969874567,0.8758753768138969,-0.2392228367016532,0.28017099900313047,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10040208729355066,0.01873270847786331,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07193117190008276,0.13466006344357873,0.5945567185976484,-0.1956355058364726,0.3394978496366381,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.0320873612234387,0.21200701082836101,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015657671674333202,0.13444125801101842,0.9075465980487045,-0.25147424432838855,0.2827895876770549,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12366135647160799,0.021815664551410343,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0047260821694224105,0.151150220135693,0.975126260145049,-0.30505835000472975,0.295606185665885,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.10176564782287967,0.020038130512177208,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029985815221128875,0.14191523769162198,0.833141063648693,-0.31196836964975266,0.25199673920749494,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.042273157480846715,0.15025417748067135,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016901722839479206,0.0938448041132889,0.8574812208017354,-0.16956590399296526,0.2033693496719237,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03169822404306249,0.0039403528603235895,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0064570217283557935,0.13239270767492672,0.9612104927853189,-0.2566044683916854,0.2695185118483969,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.02746800847052291,0.18145525690283223,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04884669073824161,0.10999367604850344,0.6580580483369153,-0.26740178212701216,0.16970840065052892,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.057512869289949496,-0.023256609213870426,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11945014672194437,0.2093216618789601,0.5696725302174219,-0.5353678302206939,0.2964675367768052,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0144849432649532,0.2129643851521584,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03457003127531087,0.13645723764589182,0.8005900285144777,-0.30570765587116455,0.23656759332054278,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.05751342965780381,0.06833283061402436,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1651380629435319,0.14270828873285632,0.2502983357655175,-0.4486963928987096,0.11842026701164582,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0739511783997,-0.024298839414673826,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10753117235518588,0.1613858388588566,0.5069437007162769,-0.42820139656968703,0.21313905185931525,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.013192639906126897,0.1589125210023679,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021778478779796148,0.1223368600674078,0.859111385362976,-0.22130225633862366,0.264859213898216,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.04527213759622206,0.18794884468252895,0.9839478606341621,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1458049713609465,0.13203340681281187,0.2724381168467392,-0.40815253832125115,0.11654259559935815,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.1283161266356453,-0.14177790343436153,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09681205699172547,0.21005039949229493,0.6459952512680507,-0.5141777266057005,0.3205536126222495,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.0736048426817416,0.10004811602753383,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053269100861085036,0.11056837304108552,0.6311482254315531,-0.1664279012106164,0.2729661029327865,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.014891729154761583,0.06686505273724404,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012705818437992381,0.11097578845478348,0.909105840526859,-0.20780070938257747,0.23321234625856221,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07516068554695368,0.09328009663544837,0.9888301126476031,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10418006156830727,0.05533848069852993,0.06302197251686058,-0.005776320842711166,0.21413644397932569,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.06435668848082128,0.0107207394214319,0.5817074626033015,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031711690449391046,0.10143599489177985,0.7552949663758508,-0.23326285166258554,0.16983947076380346,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.07109008154962429,0.06906325011033856,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023363897302848474,0.06926655834351284,0.7366818304291001,-0.1142672787138206,0.16099507331951754,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.12572625455916364,-0.11917735152270423,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014210096703145344,0.10236214642291767,0.8899046083255088,-0.18918130787493512,0.21760150128122582,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.05286144079009655,0.10639039435798363,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06897650897525175,0.07340971968061845,0.3499607902776789,-0.07688704036686415,0.21484005831736763,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.02607175052614016,0.02408246888025683,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02202965303909578,0.10482679393736515,0.8340287103137207,-0.18625895365198292,0.2303182597301745,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.021698871758071173,0.0704000422238299,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03136194083601333,0.07829192530027726,0.6896915909506232,-0.12420244707897447,0.18692632875100113,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.008207326569311453,0.03075336588882326,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008188954561849027,0.11513251071131259,0.9434567869651092,-0.23695480096590588,0.2205768918422078,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.006647648937914552,0.06892792942962374,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08599810626954715,0.06959026745021143,0.21979303817342333,-0.05227627284696823,0.22427248538606254,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.046008113447224684,0.08506513438310301,0.8339173235202663,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.000619577407995921,0.10883369406458773,0.9954705028605509,-0.2168698093029149,0.21563065448692306,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.08338227660573286,0.11221664398975495,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1329821725231079,0.08248311489001778,0.11045147587052019,-0.030910019832286778,0.2968743648785026,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.11327765148231617,-0.0533878009489832,0.7002905874282662,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0696340018464753,0.09552794756170128,0.4679531425694583,-0.12017799516617812,0.2594459988591287,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.026061391609350604,0.09941577658782752,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04447693134080434,0.11011818089058766,0.6872538059491263,-0.1743255485171729,0.2632794111987816,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.003814666422052029,0.05911322467063462,0.9631797688191589,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008655704174229032,0.10209490979140701,0.9326259545768505,-0.19420470690931194,0.21151611525777,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.007520228334348125,0.07597801255668965,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037399946162911056,0.08268091454182802,0.6521241568445013,-0.12688526988740034,0.20168516221322247,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.004577956485452771,0.02518493546344116,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08067128016020385,0.09831551018683746,0.4141037060695957,-0.11467954441213497,0.2760221047325427,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.006693373500822112,0.12310868522520362,0.9264811777847943,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0010819560284461957,0.10907216643150493,0.9921076083541533,-0.21564211537995812,0.21780602743685049,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.03940228880413824,0.03664588743281163,0.9994099232379783,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05157913963231443,0.14023723920606618,0.7138962422204362,-0.22706926754770618,0.330227546812335,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,0.24401110047896857,0.39713014374828204,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08161418489068718,0.13751720340602153,0.5543629730535184,-0.1916295690927502,0.35485793887412453,88,5,93,2,log_other_mut_burden|lin_Uterus,False,89,-0.09543771204367185,-0.07407341445163304,0.9491210479105492,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08216955229395108,0.09649820368470961,0.3950259856356886,-0.271913316827028,0.10757421223912587,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12356042446088032,0.05960655382751339,0.920957044807631,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044244256568336936,0.10130816679204856,0.6625582802734755,-0.24344581899197007,0.15495730585529618,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05156089179617044,0.009106102711439206,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017284898589128014,0.05056833378470329,0.7326828122640072,-0.11671707092079948,0.08214727374254345,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.036820051952357026,0.022592007914204137,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05536162401247173,0.1027251554317244,0.5902543913987544,-0.14662615357917808,0.2573494016041215,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1357012485088872,0.2098954136232945,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01880711780462863,0.07779429725944687,0.8091022261933116,-0.13415928216527667,0.17177351777453392,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.14581621407472475,0.1462523382886521,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12668253014104755,0.0684668232412314,0.06505806082991963,-0.26130838110360277,0.007943320821507671,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06709513372326031,-0.05710019401319723,0.5895329758766005,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14106431586329812,0.083128566886417,0.09053527786843314,-0.30451945408332426,0.022390822356728013,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11852749926253221,-0.02018560039686049,0.6632964530955446,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03377092039475304,0.060636928051800223,0.5779021422796164,-0.15300090146115689,0.08545906067165082,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13867028604804493,0.08637767555566853,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013873007862615905,0.052895205740766255,0.7932542640782096,-0.11788049276665798,0.09013447704142617,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08325937536977684,0.05923054027260643,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012776928274663856,0.10415558846608129,0.9024327277797048,-0.21757735665656205,0.19202350010723432,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12238378953372114,0.11538892505768004,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01709664399052231,0.062364517669541514,0.7841271465142967,-0.13972357282508896,0.10553028484404432,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11305362742969383,0.11266720665920647,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029680363025789788,0.10750846269735637,0.7826423930407725,-0.24107352530692927,0.18171279925534972,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12120891982837953,0.09186333081866893,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028096172285183147,0.08394493135634563,0.7380397922791597,-0.13696417786460507,0.1931565224349714,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10245218744691026,0.1364051099396029,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0077789435321370115,0.06310287042377552,0.9019559921647653,-0.13185769038809886,0.11629980332382482,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09766817975191361,0.07580291236158868,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2169282256459882,0.08287824561980821,0.009217050456155536,-0.3798911588543622,-0.05396529243761419,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.014678961532622159,-0.2343013362386059,0.1972100984392524,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048920431582092305,0.105438311764158,0.6429362537458527,-0.2562430700999075,0.15840220693572288,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.01040993564634277,-0.08029950108601773,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05129856755601015,0.059344132816763304,0.387905447647506,-0.16798653410504744,0.06538939899302712,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04264530878336423,-0.027313649560684546,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02420109060496283,0.05728494161719675,0.6729244777829293,-0.08843790223078396,0.1368400834407096,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12563596934229235,0.16599009535987475,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007774671481517197,0.06903915150332586,0.9103978710161202,-0.1435258876306959,0.1279765446676615,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07399225866431325,0.06604508106991273,0.9891749114349121,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011080802315169443,0.05743903375652424,0.8471303625518551,-0.10186118085080653,0.12402278548114543,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08047596205553431,0.10789687877467949,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03061183960421504,0.09345327758022706,0.7434243752884749,-0.21436838655470083,0.15314470734627075,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05665437722623677,0.024697678684643454,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0550757515846839,0.07558862985719861,0.4666847520544225,-0.20370516267572997,0.09355365950636219,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09761752681669457,0.06363125751629758,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014161768003245504,0.06594071647865084,0.8300668558839048,-0.14382055234235797,0.11549701633586695,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.021373691090360598,-0.042458854827685084,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009509229386745064,0.08755312351998072,0.9135689984027651,-0.1626458845839717,0.18166434335746182,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1232980940725214,0.12914594515900213,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034785138539439396,0.06088066088827312,0.5680929491753379,-0.08492409275304943,0.15449436983192824,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07553868501172747,0.10752374386475605,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021724075303473412,0.05808387279525388,0.7086060767851112,-0.1359340011052131,0.09248585049826626,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.14446077660970266,0.12774496735236593,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006787832040327128,0.059195439338071414,0.908769360794768,-0.10960775952833537,0.12318342360898962,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.022166401353097283,0.027668498265134834,0.9888301126476031,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020736365568796353,0.05286365584915106,0.6950874192771964,-0.08320908299698146,0.12468181413457416,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.16809351836084901,0.20230549954462335,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04557022344682676,0.06650901141415341,0.4936565122171369,-0.17634644226979404,0.08520599537614051,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06834512137939394,0.02434682408939192,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011119002925626856,0.05494663338986675,0.839744713030937,-0.09692219027498991,0.11916019612624362,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13122131321142375,0.14559320407339268,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015041367830676125,0.06041284087963803,0.8035150288249714,-0.13383072780771182,0.10374799214635959,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10453961830409528,0.07618038272589442,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14171707685763105,0.07874754404157334,0.07271937310912772,-0.29655783952096726,0.013123685805705193,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0653538160206238,-0.08168907817240204,0.6233762243415291,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08131198679472719,0.08641793206987322,0.34735217140227737,-0.2512349815032769,0.08861100791382252,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09275472298989296,0.010503613445529402,0.9086350165348037,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03651824449136876,0.06837343622381678,0.5935880582366321,-0.17096046919388846,0.09792398021115095,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04417011892980904,0.008541824002644733,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01635468304107992,0.0900075694762043,0.855913397260166,-0.1606265913947424,0.19333595747690224,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0729702896594442,0.08615388731211945,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015564310554521623,0.06054315791761371,0.7972592237696656,-0.10348129093193219,0.13460991204097544,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13625171542106437,0.14846801326915052,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010656025213819385,0.06491368648553972,0.8696958884729133,-0.11698331700367604,0.13829536743131482,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10202979422746235,0.10341064804366056,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07080189410661114,0.05855198588419061,0.22734034773166745,-0.04432847929239439,0.18593226750561667,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.18190916083206787,0.25423923677879806,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0005179879508613003,0.04739534554075201,0.9912858185803743,-0.09267515908046761,0.09371113498219022,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0606653337581169,0.047063787891795376,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027174644494348716,0.05030540103095063,0.58938348647896,-0.12608981393258722,0.0717405249438898,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10444346634155706,0.05957273725502108,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0060917808968481875,0.048059526915919644,0.8992021416409782,-0.08840734147541893,0.1005909032691153,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05654881131532343,0.05046618076213815,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008821457949999046,0.05358798870587132,0.8693344379612553,-0.11419115730761702,0.09654824140761893,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08339307047748848,0.062224132808931264,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037331947780884354,0.0550172401285436,0.49784044532144467,-0.14551197453369574,0.07084807897192705,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.073059563801862,0.02414770870226468,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02718068906126937,0.04793269483573246,0.5710121394332348,-0.12143042237302187,0.06706904425048313,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12491906385448534,0.07768108591747987,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015062564935758296,0.032412719563385414,0.6424070242923505,-0.07879547595248595,0.048670346080969366,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06178480363694759,0.04405040392878175,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07989448481460974,0.04456069326249693,0.0737867485595161,-0.1675138742641319,0.007724904634912419,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06579659625755788,-0.027963994793212398,0.6234452489529284,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009829656136142857,0.06256122117500702,0.8752341438226142,-0.1328433617416619,0.11318404946937617,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07639274972771597,0.04940187791729748,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05660652299231069,0.03970247577775453,0.15476495193192044,-0.13467323229571004,0.021460186311088668,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03735165129655414,-0.03054050171289719,0.7731429757303867,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0030486594254214494,0.028401646513543568,0.9145757582225065,-0.05889462466250703,0.05279730581166413,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0643341023598448,0.03665883199760039,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.048543850780314014,0.05409438799596837,0.3700842129153572,-0.15490927963331033,0.057821578072682296,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09193112914663003,0.03988758024523069,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07198927248135419,0.04233057541681881,0.08983655390396306,-0.15522359631065058,0.011245051347942223,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.0929032403569804,-0.18725089325721117,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024785237679531127,0.04802305044111216,0.6060800654863439,-0.11921263660636,0.06964216124729775,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.21270903848459358,0.17699185876790208,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08927048484087878,0.08976219446680944,0.32060833881432294,-0.26576928005711853,0.08722831037536095,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.046074102575376155,-0.03661845005813203,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08480862538001674,0.0745176417074288,0.2558028422857643,-0.06171490896360718,0.23133215972364066,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11907457195684353,0.22789362409547304,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.018512047592009234,0.05355333076272381,0.72978029370106,-0.12381359927067903,0.08678950408666056,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12487686691709227,0.10629899805851462,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05046931279703825,0.09369296138904584,0.5904353606676791,-0.1337585228038715,0.234697148397948,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.17388033694390453,0.20572727879642413,0.953198269875948,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062041264571692636,0.06908872270320936,0.3697633530941601,-0.1978899522355645,0.0738074230921792,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08519740997518234,0.006096428358371028,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07669752283984438,0.07691048669617559,0.3192937175799554,-0.07453104640362468,0.22792609208331344,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.14713152084114547,0.2566014848063021,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02759522556402511,0.06769596889371551,0.6837738824981725,-0.16070535084237744,0.10551489971432723,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09621875535263133,0.05497774822281506,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025359420571987593,0.07520406587857256,0.7361481809352249,-0.12251382497170038,0.17323266611567556,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08690029919878373,0.1090761427718576,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03187096707413123,0.03667605979387105,0.3854093628395773,-0.10398685511974465,0.04024492097148219,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09591442735545583,0.038664349736575336,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03800805010581687,0.06334515607584507,0.5488576031667125,-0.16256320159897003,0.08654710138733628,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.009356603925290906,-0.04792159408820109,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022850677782561536,0.06926414116386896,0.7416544706896955,-0.15904428957790118,0.11334293401277812,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07782382151113994,0.028620619938619005,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023215265467575682,0.07491037910404025,0.7568032191393159,-0.12408050575985027,0.17051103669500164,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08431714321847066,0.12235699976933491,0.9657451822173873,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11525631430601796,0.07440101805772818,0.12219345244492225,-0.26155053235687353,0.031037903744837614,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06669159691419017,-0.05325427866208584,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02336545694336778,0.061292525281413913,0.7032611264945903,-0.14388453440342885,0.09715362051669328,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11219415710125716,0.08056783775291068,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12387636499424368,0.06976062364341189,0.0765853749418338,-0.261046206927514,0.013293476939026688,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07309290454128584,-0.05491751970151763,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011957470974952476,0.05667447605471319,0.83301318376847,-0.09948116755863659,0.12339610950854155,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.18059609005651486,0.18497212903260987,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014192068453747039,0.064707560338529,0.8265149045071071,-0.11304196931652466,0.14142610622401874,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1103018866922046,0.10649375559212274,0.980692368074751,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08723358989102724,0.06348794867528741,0.17025458033423768,-0.21206951350564057,0.03760233372358611,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11305229499837291,0.010695924809986433,0.7843765865891925,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007892061325543103,0.0553658985561364,0.886726897138288,-0.11675765278382604,0.10097353013273984,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11006077996231746,0.09383264369032153,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010585682629446178,0.058709368577558055,0.8570090663809145,-0.10485415129391754,0.12602551655280989,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1338900451354876,0.13159309316169768,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06058491498197289,0.05688434828718312,0.2875348490176899,-0.17243622386526003,0.05126639390131426,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08161075820466072,0.006234730460867776,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054864599640221445,0.09965402601068198,0.5822686081929218,-0.1410844369649035,0.25081363624534636,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10268640220940793,0.17813739385109834,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07427960345778638,0.03888556561563099,0.05686664850922194,-0.15074002784055557,0.0021808209249828264,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0794913075657497,-0.017240344402232575,0.5579820220843063,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01728504780793463,0.07701758400758837,0.8225447224964837,-0.1687242017696978,0.13415410615382853,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11774413241364623,0.0937827854001845,0.9796489133048895,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05546622195616527,0.05148238485329183,0.28200014077440516,-0.15669568671512524,0.0457632428027947,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07821094056271263,0.0037651591034999934,0.8770089248428307,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027451465892557075,0.059359384126973475,0.6440174710584567,-0.08926648920448255,0.1441694209895967,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11079312603685298,0.12979176316238725,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04972931026235307,0.05763464114405044,0.38877700852624486,-0.163055914909999,0.06359729438529285,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0637952876245759,-0.0028935244522964904,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05431798558649651,0.057251252428198715,0.343349526972906,-0.16689073559801998,0.05825476442502695,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.045684403838723575,-0.01364819485911148,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006221089336274228,0.06720768193880294,0.9262983280977048,-0.12592892060873764,0.13837109928128608,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09855284420947762,0.10663448208228461,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04713065349792688,0.05034379294559391,0.34978343525348266,-0.14612131269798365,0.051860005702129876,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05064419612943536,-0.03671154317489881,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002703464600151981,0.05750355417253285,0.9625271338000747,-0.11036538462296545,0.11577231382326943,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08331246948530287,0.07588272795580223,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07846868277583531,0.04467715338717449,0.07984285937883177,-0.16631706697998017,0.009379701428309559,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05183564125054821,-0.051026917792683826,0.6378354016929029,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006753894858710063,0.05375755031133275,0.9000870471604483,-0.11245700205307538,0.09894921233565526,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06930599102022811,0.06161118243818976,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014359765310537214,0.04840331996896449,0.7668830209079962,-0.08081535501417039,0.10953488563524483,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09370456628668768,0.10888084252568252,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05828522030165585,0.10632948743191314,0.58390960013004,-0.2673601715009861,0.1507897308976744,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03183840630882842,-0.039727941666957,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0005970934577723959,0.055011638268448064,0.9913457290818264,-0.10876610531100714,0.10757191839546235,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09769889565052207,0.12377742631530572,0.9992761255456871,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03932315012043434,0.07537047950794543,0.6021645073722979,-0.1088773134159324,0.18752361365680106,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11541474008348754,0.15264266792464729,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059448491785044584,0.04915417650653583,0.22725792266312833,-0.1561000162356627,0.03720303266557352,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04398671447155469,-0.030614848295762852,0.8428900888808857,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04854278002128682,0.06781197787842635,0.4745321534014547,-0.1818810129807999,0.08479545293822627,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08881466951443077,0.04250834573601132,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028560031127323266,0.05617953487883658,0.6114915059129217,-0.08190540792329827,0.1390254701779448,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09932582279744448,0.11064279591917632,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019308407509204824,0.06852713269568049,0.7782802875570374,-0.15405284454369866,0.11543602952528903,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08864046848904963,0.08194579376632613,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052044544819031535,0.05722793179877495,0.3637080973583411,-0.06048234999675581,0.16457143963481888,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11858663668304661,0.16137564407243632,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020932044121318716,0.07616598443379873,0.7836043815411627,-0.12883261536453106,0.1706967036071685,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10659436291263048,0.14180837548144037,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00912507882982308,0.04400746508987959,0.8358464578683301,-0.07740650180969114,0.0956566594693373,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11448457086655935,0.1277925408006788,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05544517151365854,0.051600625401251946,0.2832850911611087,-0.15690713186148678,0.04601678883416969,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07783873396286364,0.032445164728462074,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02054568112847725,0.08230058177304696,0.8030005487886139,-0.14128139556926927,0.18237275782622375,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1205514523732713,0.13916725115279777,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011916180523869585,0.056690829182133015,0.8336286245343736,-0.12338697410118014,0.09955461305344097,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09543856353756372,0.09437372879074753,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027253735108068684,0.05509962730071765,0.6211526794391509,-0.08108828898355966,0.13559575919969702,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08753275857638305,0.10391419094792294,0.9582992440631078,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029473746966005656,0.056183615279938155,0.6001726241392065,-0.08099971534967423,0.13994720928168555,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11867906839872756,0.12499945390668639,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.045872650999682484,0.03980783495582545,0.24990844477519614,-0.12414652734155443,0.03240122534218947,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03921378303592005,-0.010429782882708896,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07406400008641156,0.05160389153877156,0.1520498473866132,-0.17553238261833018,0.027404382445507053,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08318415277268093,-0.013725473158725632,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12377224099828904,0.062472810923118474,0.04829496199058065,-0.2466121061241297,-0.0009323758724483766,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.007839728936418596,-0.13528657997968804,0.5211737888853413,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02148889082033204,0.05385794672256844,0.6901255918047062,-0.12738940679834387,0.08441162515767979,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1011570640109399,0.06567769133912839,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08063116511104904,0.0631116114159144,0.2021800406887519,-0.20472709932066985,0.043464769098571776,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.025923006318224157,-0.04541424062987266,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04908035852043008,0.047063556799366614,0.2976865413093381,-0.14162111159605542,0.043460394555195264,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09207895863897404,0.01395981071364105,0.8847007730863069,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08892634610001035,0.06644169064892955,0.18157096649961962,-0.21957019255813487,0.04171750035811417,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0069817745088609166,-0.07434912395295785,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07126520562285796,0.04150768463871858,0.08681803733858229,-0.15288148488682293,0.010351073641107017,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03249309567704265,-0.0696509396591201,0.6563443622796822,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05964293418981511,0.048332538273257605,0.21796916661621193,-0.15467887694550453,0.035393008565874316,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0515633679170533,-0.04337304787970363,0.8322459088982637,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002942646629665858,0.047207273673003786,0.9503294954071564,-0.09576598922084258,0.08988069596151087,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07904684388066857,0.06209947568184454,0.9937952805575481,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016904183103405263,0.06494306943948588,0.7947807674888713,-0.14460130082429828,0.11079293461748775,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10345484335106574,0.06966782756405925,0.9733769568556405,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08203515335590157,0.06302399214221482,0.19383312396511043,-0.20595880238090142,0.041888495669098275,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12463270858214152,0.048234721396397916,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06937187990460046,0.08557307078928755,0.418065610571145,-0.09888986978833907,0.23763362959753997,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1258064543996059,0.19945558336955724,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05547216877995606,0.04237515554295503,0.1913091011663388,-0.13879415020943003,0.0278498126495179,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07257369458353216,0.0038710806973393896,0.8124017632787565,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016826100286239053,0.04990458608491063,0.7361803375206951,-0.11495315000992579,0.08130094943744767,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10066515915730621,0.08517665083773683,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029326936108020774,0.05348158962416073,0.583773090306954,-0.13448742367168048,0.07583355145563893,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13422332251791202,0.08322111398093844,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021534630519097982,0.06395634464010796,0.7365246735742155,-0.14729155794791224,0.10422229690971627,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1191332130263083,0.09913006719307464,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04315965525038686,0.061442334924083644,0.48283840781061793,-0.163973302396495,0.07765399189572125,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07354298760322091,0.01435936305792711,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0067729139824618395,0.06752688739815053,0.9201600007868946,-0.12600474749598178,0.1395505754609055,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11624544671147696,0.11048913956090144,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03251080806918438,0.06625863248605274,0.6239494567264428,-0.16279470850109848,0.09777309236272971,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0610390945911417,0.0263298705391865,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11364383642074673,0.09512336853035791,0.2329575347412462,-0.07339659905709268,0.30068427189858615,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1477617410104422,0.2579431487104887,0.8443484327374559,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005164255213194642,0.05957473610742851,0.9309677870566191,-0.12230565545129304,0.11197714502490377,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12363083747923581,0.13516985141959198,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020960287992539232,0.08882850209549845,0.8135894382359432,-0.1537025942358566,0.1956231702209351,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08005249675135603,0.08680932272115627,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06090673887106256,0.06332014579260671,0.3367252203869191,-0.18541271281362431,0.06359923507149919,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0954610518291375,0.044103255913640275,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047014005944381806,0.07359958921861814,0.5233544371972076,-0.09770436800646377,0.1917323798952274,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11632850955994788,0.17347946533286618,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01874672071690761,0.05587441796509333,0.7374235479135334,-0.12861221044592813,0.0911187690121129,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11791270371679163,0.0821865699049347,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09465326229389905,0.05065681728580674,0.062467089321777795,-0.1942594191346842,0.004952894546886091,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.00929026169515992,-0.10675289802375733,0.5810248874960544,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0841828632600435,0.06416302958513588,0.1903154757111945,-0.21034619389683917,0.041980467376752165,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12888264099993865,-0.02674011228599618,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007408832318758779,0.05727719746518126,0.897149503903164,-0.10521493324331423,0.12003259788083177,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0675102613355925,0.06519359307622875,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07217134026682369,0.07767373868898114,0.35340222547402134,-0.08055800620225549,0.22490068673590285,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.15846321941641722,0.24363733022534026,0.9093377198744834,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04903909305415821,0.039298363893600315,0.2128566856163243,-0.1263111998959148,0.028233013787598377,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.06210663059251698,-0.12651531298641513,0.8287975391843301,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030632096381910674,0.04781009586647066,0.5221056124689808,-0.12464076417049952,0.06337657140667816,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05628612298693552,0.005902166884482997,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007104616949580359,0.04239722439629346,0.8670095475457624,-0.07626075831678868,0.09046999221594938,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0854863257564634,0.10292221904794518,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026020234517662152,0.06313335532016048,0.680466417836399,-0.15015892361897792,0.09811845458365363,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04471524518269163,-0.0005367555095948114,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021164594439396948,0.03388794285314157,0.5326475547918571,-0.04546903814350382,0.08779822702229771,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09703480811783607,0.13115742099131697,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024783590677794707,0.04254328367101278,0.5605454317679418,-0.10843616130710297,0.058868979951513564,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0940612753061921,0.03860668531032597,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006794107569045624,0.045360522824200104,0.8810183506933716,-0.09598619647024108,0.08239798133214983,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09943522434595062,0.07426741990058694,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04577646704896093,0.09757769996840575,0.6392497832494431,-0.14608990371767047,0.23764283781559234,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12663878086258673,0.18457438077050842,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02804000663452955,0.06565872955698425,0.6695823952235319,-0.15714432199885228,0.10106430872979319,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06508765530036652,0.03329550994180077,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034848830974555614,0.04275575216500477,0.4155495466850936,-0.11891917696501396,0.04922151501590273,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05441384832379242,0.009832803356815887,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03644484000413162,0.0864177169803604,0.6734639877308516,-0.20636741178362858,0.13347773177536534,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08423232673682203,0.05852566812866238,0.9604420702583071,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,1.1375253302707469e-05,0.0641765546025295,0.9998586694729874,-0.1261785495336185,0.12620130004022395,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10756489962606192,0.10128326775709603,0.9998586694729874,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07792626043639088,0.07089344470230075,0.272383002416561,-0.2173235607476246,0.06147103987484283,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07868098892587692,-0.005163208316197509,0.870021716674458,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01775792552261187,0.061948653517137096,0.7745339622743348,-0.10405129244482414,0.1395671434900479,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13676416065572986,0.15796330569105327,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07212889294035452,0.08197939357139448,0.37950702277999593,-0.23332441945189994,0.0890666335711909,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.018463483528655587,-0.09242418343577595,0.9190136506490566,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.076703627887409,0.07551991160470589,0.31043765101806536,-0.22519791874385772,0.07179066296903971,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05180478356872476,-0.03544084011514269,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053955487432462125,0.07600506096301066,0.47821028700699775,-0.09549274932236126,0.2034037241872855,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07246683525730294,0.14416809831739633,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043009950442146776,0.07061655099318813,0.542850287288241,-0.0958428956436568,0.18186279652795037,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08846399970262384,0.13460744931469473,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09984692477339413,0.061176906112829846,0.10349526387674901,-0.22013866104510516,0.020444811498316895,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,-0.01864869294681807,-0.11021455255521273,0.6840511279380797,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07420521754386157,0.11400360050242134,0.515507057485063,-0.14995929022595478,0.2983697253136779,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.4135573318313975,0.4881611456312194,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05811323938163278,0.06225447919094161,0.35117184158177905,-0.06429732153751383,0.18052380030077939,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11606135731581932,0.1751181245455729,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03435775115669907,0.05697848777412384,0.5468754532566524,-0.07767866356235792,0.14639416587575604,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11908617414931427,0.14826837343383345,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12535941938367706,0.05525567573251964,0.02385183406398922,-0.2340082804501815,-0.016710558317172636,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03817250849188121,-0.09974107922255537,0.3634085581572868,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03360576485005733,0.04671114999034707,0.4723181545984174,-0.05824205310307667,0.12545358280319133,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10879077832043546,0.13008139930210644,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12320786378976478,0.05989497786693876,0.04036928211846847,-0.24097895323128823,-0.00543677434824133,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.03707157421863896,-0.10611944418317586,0.4840655006894301,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1281911404933058,0.05960209139575161,0.03213017446063113,-0.24538632924961612,-0.010995951736995455,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.043323322413109426,-0.10026239707631139,0.42865432751006705,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02603686000680868,0.06412932999651415,0.6849695235465219,-0.10006020735705398,0.15213392737067136,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07037038039312166,0.09608370138574644,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05696088946122817,0.05029241194418676,0.2581064672681361,-0.15585051854610965,0.04192873962365333,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07437389731850755,-0.018963495047830337,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017716593675487127,0.058429763956031576,0.7618961535836606,-0.09717345557372221,0.13260664292469648,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.13200689049663197,0.13745186178938326,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11220609795872062,0.05572511228644781,0.044767329589435745,-0.22177800894274263,-0.00263418697469861,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.027274304772156237,-0.09082337785553969,0.5055162930315735,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023736430441552003,0.08787777445707327,0.7872258771120664,-0.1965299033517201,0.14905704246861612,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12505842766389302,0.11279848708633523,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06583814930482176,0.06921442400435324,0.3421037109259104,-0.20193400258603167,0.07025770397638814,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0749579152307801,-0.0013019412980470027,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018483667104591667,0.07152475464484241,0.7962215923284,-0.12215497367217441,0.15912230788135776,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0880994791836998,0.09617494355938798,0.973718533338906,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03422007419111497,0.09118457407137648,0.7076611775095079,-0.1450755364109057,0.21351568479313565,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.11306106575405676,0.1482858442222172,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02319156137345299,0.04617362211381917,0.6157725945600044,-0.06759931915556981,0.11398244190247579,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.12474043941661545,0.13970555157846434,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13284913601986809,0.08017091433011776,0.09833864180167816,-0.2904886620441822,0.024790390004446078,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0008156707405645883,-0.1328801722081157,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10609610041657754,0.08352574269136694,0.2047915958151241,-0.27033220273267,0.058140001899514945,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10408946313384577,-0.016953524818345254,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04738420308932903,0.04559455568361674,0.29935568104580496,-0.1370364692174006,0.04226806303874252,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0738559925358347,-0.004203887702675891,0.8866736552767163,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005487483790375353,0.04664178647111048,0.9064064887586557,-0.0971989127252825,0.0862239451445318,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10934177253323853,0.0837269382805722,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13652214678855795,0.04146787536417471,0.0010880564055609024,-0.21806014934552884,-0.05498414423158707,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.05848202914693751,-0.1340423236572423,0.03873090469660288,0.37013945430091794 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014870258676848899,0.047397421871732494,0.7538958382094292,-0.10806748838372626,0.07832697103002847,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.1275399594659263,0.0992194207478789,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.20682645726547913,0.04486423081676904,5.524317847689195e-06,-0.2950426905527678,-0.11861022397819049,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.0415761800687173,-0.22864291926452393,0.0003654336256246402,0.0034923378070167866 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02451349195313935,0.04327949766662159,0.5714600489683916,-0.06058669127096055,0.10961367517723924,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.10514063148491128,0.11049006849818128,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10469532816770123,0.04278970157412755,0.014872556986592147,-0.18883242865145228,-0.020558227683950173,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06738518554145134,-0.08422848136778427,0.2652996794597044,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006969000013169659,0.053575744705681855,0.8965746554562235,-0.11231462407611703,0.0983766240497777,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07969800573944354,0.04909749102686683,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09991887484907266,0.03621329751140833,0.006078079369838312,-0.1711248365519607,-0.028712913146184613,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.056938954140968,-0.0664846145134849,0.15030465432329135,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013361432318201884,0.05221059361742423,0.7981570362437453,-0.11602276903950341,0.08929990440309964,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08360796973569551,0.047346722655750295,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10616667600377803,0.03628833285511314,0.0036460502940816814,-0.1775201791949419,-0.034813172812614174,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06241426036371586,-0.06445180723603548,0.10155209555936978,0.9705024328222499 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002128469089429675,0.04888081718517709,0.9652909600414714,-0.09824248895732741,0.09398555077846805,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.08107176849240984,0.07031521283795554,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10100233479228249,0.06184944741141743,0.10329863399080279,-0.22261648446574883,0.02061181488118384,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.07263007797324711,-0.10943830638356293,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028083239386196453,0.04338195037372983,0.5178014617259903,-0.057218395902201326,0.11338487467459424,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09037775940062112,0.10009665597649582,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0706247128386903,0.03736605064615635,0.05951653882072321,-0.14409732522534702,0.0028478995479664093,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.04116922950927048,-0.047936650468411744,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021602636110310484,0.04738679440996735,0.6487402929407802,-0.07157369689045473,0.11477896911107568,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.09757808511808658,0.09667194847007068,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1324453189911815,0.037818918640250505,0.000517127596213775,-0.20680840264833694,-0.05808223533402607,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.054120996205911244,-0.10140808606777907,0.02062793396354244,0.19713487925033316 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031002389939224235,0.048639648848417046,0.5242592379993753,-0.1266422021394586,0.06463742226101013,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.06005544003539474,0.010954952081804244,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021380913877860567,0.03948562505553561,0.5884933274342217,-0.09902123107441851,0.05625940331869739,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.036011470332195046,-0.006562934319921241,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08063222845921542,0.05952748576093789,0.17637824806281552,-0.036416263742502175,0.197680720660933,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.17664577951329893,0.2638374030797864,0.7917994815735138,1.0 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12999940256503748,0.05925839334419273,0.028863308579914277,-0.24651878016968592,-0.013480024960389012,369,14,383,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,376,0.015287686147456379,-0.14624609310657263,0.4046097093301284,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003361350080076656,0.16172108872417507,0.9834382061374713,-0.3155554634183227,0.322278163578476,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16630979589992753,0.227194448728242,0.9987887001431995,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08627795217901557,0.20111224902443828,0.6683867392680369,-0.3103189179036595,0.48287482226169065,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16256524412036036,0.22993401408000536,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05548458739314736,0.05509446375965401,0.31512498772047975,-0.1641318328590712,0.0531626580727765,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07412478029064702,0.025475942073922467,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07002967885037452,0.18195126120864985,0.7007382960447044,-0.28878138836700346,0.4288407460677525,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2581530555644639,0.3219841330017202,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06633505364579445,0.1395172606057193,0.6349823412047564,-0.20879542272819046,0.34146553001977936,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22740524140841245,0.17004713427541285,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10271497772589824,0.1118020609641061,0.3593589849324521,-0.32319059600496614,0.11776064055316968,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09079341340965807,-0.0019187996212247903,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03160204304206439,0.19692669146310407,0.8726695890382412,-0.35674083437517984,0.4199449204593086,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23312442616189952,0.1939043611739679,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006475289216805562,0.05825193933075045,0.9116020201041404,-0.12134913169476516,0.10839855326115405,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16666920408951852,0.09705382063343888,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02942339280679314,0.09855123513577041,0.7655893802904126,-0.164921365343064,0.22376815095665026,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14212847038094198,0.10982582884063573,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11242972486777308,0.20471519538828623,0.583486575268176,-0.29127221841610823,0.5161316681516543,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2509204243567072,0.3110742472215927,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06276140897371218,0.08856072827735419,0.4793552682702993,-0.11188189503892876,0.23740471298635313,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15762008413506975,0.2608443679732517,0.9384017168502401,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11141631660699033,0.1951318870407539,0.5686609865412979,-0.2733871751200858,0.4962198083340664,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.24829460657325814,0.28633994741482177,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05610769399569381,0.14964642554705654,0.7081100438304371,-0.23899767267847044,0.3512130606698581,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16038032961207757,0.2183121783894284,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10222649707185888,0.1676146978638141,0.5426340921971309,-0.22831261665743025,0.432765610801148,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17340880416354323,0.21086598410811253,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.25329900725509996,0.12241850977177006,0.03983311633970804,-0.49471044813541004,-0.011887566374789882,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.033987900718979246,-0.17336666242036922,0.48200499619604026,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2206737540721861,0.12410975867322252,0.07692982402616477,-0.46542036734552783,0.024072859201155622,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.01901596301311469,-0.26630989974834257,0.6304803200848395,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05962497120543502,0.14316646884774342,0.6775150199071205,-0.22270180760207692,0.341951750012947,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1126943926292828,0.10098642376909965,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059795597578971627,0.09710078169673793,0.5387274031448884,-0.13168884103832917,0.2512800361962724,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17615753293299874,0.24096807434680143,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012869483370216385,0.12637203290808652,0.9189882673984177,-0.2620773409743632,0.23633837423393045,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13537484868487412,0.09543166036272399,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020214163053884,0.08142999392784445,0.8042061647261208,-0.1403672081917332,0.18079553429950124,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12357247797274691,0.18665699933201388,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022096658555673866,0.18077753106583166,0.9028398695617443,-0.33439979230580613,0.3785931094171539,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14397490698875695,0.13929012031472437,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007707774816615452,0.1615398117498782,0.9619919524170917,-0.3262671069533725,0.31085155732014164,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17688700061705265,0.19289042289788716,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06227337056329549,0.09090327049025757,0.4941129593420007,-0.24153620876234558,0.1169894676357546,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.028530873194501233,-0.05072889508949665,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04725301665872775,0.1722121016062186,0.7840721609750856,-0.292352257603242,0.38685829092069746,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2632127605924689,0.26439659906070273,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006272948330587409,0.11887736635956014,0.9579697744722246,-0.22815529584932834,0.24070119251050318,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1551075500265213,0.13347378625687095,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10318490669186875,0.06644467988282325,0.12203329277135544,-0.02784516334613693,0.23421497672987443,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17156231915661524,0.24071182323945461,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0444504832623474,0.07488974775413575,0.5534934834222864,-0.19213437474407483,0.10323340821938001,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0788580263351444,0.039845239911037424,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07145390917725232,0.06665324941135219,0.28501397899265574,-0.059987463616356,0.20289528197086065,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1528066004309808,0.2070698632537632,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029532439751334776,0.08560758768319413,0.7304796734400735,-0.13928721939512176,0.1983520988977913,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12893429928107591,0.1535477577802009,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035789515908813616,0.10137834787030053,0.7244421079448167,-0.1641303579653437,0.23570938978297096,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16443003634866749,0.13700836076822123,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09726547647669025,0.17082794167867482,0.5697457819939526,-0.23961021021604584,0.43414116316942636,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19730733187263713,0.2587950984505572,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07184133534147795,0.18669312430198193,0.7007913875205198,-0.2963207687734464,0.4400034394564023,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18363062861335994,0.16964055617398152,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00437190889713398,0.19446802824417472,0.9820866076421126,-0.3791224416802742,0.3878662594745421,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21458294300379843,0.1617439905263613,0.9987474789101741,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019431067463501026,0.12478740007481305,0.8764175877488835,-0.2655140014244831,0.2266518664974811,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09551252423598214,0.07889894581285221,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027694755989782924,0.19580732316022298,0.8876670925996458,-0.3584407075700465,0.41383021954961235,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17518074092215863,0.18121665108485377,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09772093040480165,0.08996798898985331,0.27872240392447717,-0.07969751632875655,0.27513937713835984,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13998075375996027,0.1595010210087705,0.8741597954770841,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02982544118037744,0.16108317498523436,0.8532965689853169,-0.34748427763623535,0.28783339527548046,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14927453909857058,0.07341366253871562,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07234084229316817,0.08416642905521705,0.3911054673774228,-0.09363682685058647,0.23831851143692281,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12453314622109227,0.13283641139352775,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02119653726997471,0.07549315235738692,0.7791766812560799,-0.12767727863556944,0.17007035317551888,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11587850457849226,0.09282595267405198,0.9703646839991782,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06711314945715938,0.14510173960981443,0.6442129177499243,-0.2190300171174975,0.3532563160318163,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1744351154313527,0.1717302566345086,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037037911529813485,0.095507364843828,0.6985794238219293,-0.15130428120407388,0.22538010426370084,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11347192415396486,0.0874090584375054,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0635042446605332,0.15239713710790034,0.6773475281354138,-0.2370255732880948,0.36403406260916116,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15958990198668005,0.1729986534375759,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005845709703182122,0.1358070202009069,0.9657096462326071,-0.26196810774554724,0.27365952715191144,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13797879931809368,0.08371489422582358,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10329992324040746,0.19032638566504426,0.5879113510511295,-0.27202703578401444,0.4786268822648293,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2034028814847594,0.2413115327830088,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022885037678183368,0.10938982114171027,0.8345022915119983,-0.19283360151039305,0.2386036768667598,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09256793834118882,0.09176364806730901,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010403048440099288,0.132335302644163,0.9374211979593191,-0.2713705781888268,0.2505644813086283,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.130616438786495,0.07770853084614558,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03941788211201159,0.1499593990247411,0.7929340881756226,-0.25630467373024507,0.33514043795426823,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16662218429084322,0.1417696413356615,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019003440696637775,0.10852109057886702,0.8611698788791409,-0.23300892803175885,0.19500204663848328,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08538067444936763,0.03791475965071201,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06183299091487515,0.10663002891657235,0.5626524720681858,-0.1484432897705392,0.2721092716002895,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09208626184800127,0.07216272440181427,0.951415215873745,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020312405151292873,0.1253710505049898,0.8714566542436482,-0.22692149765894307,0.2675463079615288,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16052015978743042,0.14652551611628878,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016381117772371584,0.09170757730937057,0.8584160667401474,-0.19723006307625351,0.16446782753151035,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.01177237418152514,-0.005384886277684325,0.9839047884462332,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016610950037604218,0.09454857325582393,0.8607194362478788,-0.2030623890023474,0.169840488927139,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2050150738042658,0.10138593600590186,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02366265369643712,0.18010787036347262,0.8956077488151353,-0.3788385219486466,0.3315132145557724,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15104055673410488,0.11185025248280327,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03729184705841143,0.06600618298765551,0.5727302852071385,-0.16745719355517044,0.09287349943834758,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10132848398699346,0.10289216271319351,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08941516155289898,0.12297702797090382,0.46803063823488655,-0.1530976869777912,0.33192801008358913,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17170863020263485,0.19890397381183575,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12384026742779684,0.23594466683778592,0.6002607768500634,-0.3414467393780125,0.5891272742336062,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.32583976144288673,0.3578779311282581,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08392291161492613,0.1068312174588567,0.4330611475599362,-0.2945959396220651,0.12675011639221287,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15641999167058396,0.04461792013947071,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1342208800174239,0.1517622424060185,0.37754464503908847,-0.16505691448250895,0.4334986745173568,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.23353193473701284,0.3776613222565908,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05538187199810855,0.14097629150379126,0.6948563636339868,-0.22262583880757392,0.33338958280379105,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18340170494676103,0.17201605850489612,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09943870540421627,0.15594462356458147,0.52443566326814,-0.20808681783936595,0.4069642286477985,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17424831901663798,0.2421125739733835,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008757397212871805,0.09998169045714243,0.930291063746264,-0.18840824383199148,0.20592303825773509,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13884169675150768,0.08559316595482765,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025136862211903158,0.10647448869392682,0.8136119647366201,-0.18483269043594802,0.23510641485975436,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.0533565340046579,0.0579110213308868,0.9767897942462676,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039861365071597404,0.19369360071754194,0.8371617177011987,-0.34210580088797526,0.42182853103117,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1998462548584827,0.1384666935622221,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08301508075706912,0.1205580418674707,0.4918872375154203,-0.1547274848990136,0.32075764641315185,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1620704272351296,0.21648119545927522,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0688990875827932,0.12718784230377841,0.5886264794201254,-0.3197157355738255,0.18191756040823912,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1105733135392029,-0.017225174982859724,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02202609279132538,0.09608240591964858,0.8189176951321239,-0.21150227657720333,0.16745009099455255,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1599721086836813,0.10628348728555737,0.9783899072890752,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055053722078298416,0.15155411442830052,0.716797339222711,-0.3539210845685452,0.2438136404119484,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1336685091171676,-0.0005523173366257702,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008663914772057957,0.0673428185806143,0.8977621171712635,-0.12413730047551065,0.14146513001962657,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19192640836463834,0.165409551548483,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025737306947724626,0.13517917472599578,0.8491954450872132,-0.24083838825110104,0.2923130021465503,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16306581951861018,0.0954698821969606,0.9828627793326524,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05952594737597179,0.08840776301031399,0.501534402663134,-0.2338676012085079,0.11481570645656435,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16992281230366807,0.062370167709582335,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1024732893665506,0.14984838971038167,0.4948716653537204,-0.1930303541675869,0.3979769329006881,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16552874389643696,0.2161763500970737,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08204234047857596,0.1325264404153415,0.5365858525728853,-0.17930211629558984,0.34338679725274174,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18866513288776193,0.2143786468591176,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08927219311565218,0.15008426315001755,0.5526470583649497,-0.20669659696400408,0.3852409831953084,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1411412764120135,0.18244832822809878,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048026771634971765,0.1811137875287633,0.791150846957591,-0.3091327828484441,0.4051863261183876,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21818307869834172,0.3108685172041291,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005640486327244659,0.08578087627573706,0.9476395536776913,-0.1748018736069051,0.1635209009524158,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1448970003188529,0.05548897352525652,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10295192108934896,0.16620037159536424,0.5363356415163996,-0.2247981165191974,0.43070195869789535,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2400601905285812,0.2917732486907561,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033676323540889744,0.16466428651113582,0.8381611105009743,-0.2910445274341183,0.35839717451589775,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1431800225841999,0.11263018068765414,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08331999973237318,0.13712678927919628,0.544140513596397,-0.18709642540544752,0.3537364248701939,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18120587305744706,0.20368361642688382,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005743461850153432,0.1498616157491624,0.9694670898472539,-0.2897862636636222,0.3012731873639291,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1559661209651582,0.12693617626716888,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010088505990906462,0.10756168143746685,0.9253686321277408,-0.22220202173079276,0.20202500974897983,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09327499688067001,0.059463501933729374,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08399443772800619,0.1487154854610021,0.5728494448034881,-0.20927509882564255,0.3772639742816549,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17128296753557348,0.25214197466285926,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05134249700870059,0.1770673545802472,0.7721500690705687,-0.29783742097735855,0.4005224149947597,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13925554126066203,0.10654104919094037,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11244062899193154,0.1469563306731118,0.4451054291519657,-0.17735982357378238,0.40224108155764543,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.137381044341765,0.18448257551587421,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06527398257263081,0.1988484502506823,0.7430620009942044,-0.3268586367618985,0.4574066019071601,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11792734010652235,0.11727827476527129,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016623967678641507,0.09827467643984604,0.8658448943442736,-0.17717541188920582,0.21042334724648887,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13609598013403962,0.1399462230380302,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01782717719871239,0.08637356897854093,0.836693511590492,-0.18815736484728665,0.1525030104498619,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10885366278400685,0.06874099896544562,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09004196329942799,0.21848155231822122,0.680692791337134,-0.34080747645638493,0.520891403055241,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1274731209633239,0.11840742721837326,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03635294612735485,0.06176580554178836,0.5568265774665935,-0.08545030193354147,0.15815619418825116,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14868691870486114,0.20579048977938805,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062227327589945924,0.1684803079728165,0.7122654165035989,-0.2700187844032856,0.39447343958317743,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1843102588945296,0.19127583895280234,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04557961430454204,0.0797604425850271,0.5683384261205942,-0.2028686011219824,0.11170937251289831,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08634409256849052,0.0035362442251870075,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08819868176508125,0.1610353017193261,0.5845162900692283,-0.22936574777368454,0.405763111303847,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18070222069795996,0.24705172749033802,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07992150112712877,0.16068545533925332,0.6194739971404559,-0.23695302523557665,0.39679602748983417,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16233519874187202,0.17153783656395905,0.9576211468940484,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008338695937796533,0.10208151565446537,0.9349784172992583,-0.19296783709658358,0.20964522897217666,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14400003833747613,0.17233237665818446,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10426496812702085,0.13237989902102923,0.4318612379863639,-0.15679050645633497,0.36532044271037667,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14577067154288628,0.17284044509339394,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02492463799671859,0.1392143495000925,0.8580910518595993,-0.24960849238274027,0.29945776837617744,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20059815638080564,0.2369485864042322,0.9838981322636862,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021036372002383594,0.07774556586587357,0.7869961520998088,-0.1322792427092054,0.1743519867139726,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09245394119278726,0.13483701472005657,0.9724156299569652,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023475245008714337,0.06185573772388601,0.7047114126625857,-0.14545584090452696,0.09850535088709829,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07700416133658984,0.08478546211160785,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04454796423671568,0.1477303552733196,0.7633122383015924,-0.24677887836888138,0.33587480684231275,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19554501823691478,0.19876022148597086,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0238718791694625,0.0969395309435858,0.8057396641838344,-0.21503832848323345,0.16729457014430843,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1546836698475662,0.1330094770448958,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03736511668996738,0.06778904636897122,0.5821201119527069,-0.09631606755533624,0.171046300935271,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11939174213059978,0.14075666996206357,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06419460431695126,0.13603702370918275,0.6375244329830039,-0.20407278407006116,0.3324619927039637,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15668348398200901,0.1223234489012573,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0032806141115835816,0.04344518489632692,0.9398839323818601,-0.08239404983169829,0.08895527805486544,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.07319281687731423,0.047647698980877555,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061924309114060404,0.10629245707143811,0.5608360755505823,-0.14768627399272458,0.27153489222084537,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1315396877226303,0.10864749992212286,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16223229249995194,0.06485625434010016,0.013180348269898992,-0.2901299596054699,-0.03433462539443399,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.044512188054564625,-0.06439038171625791,0.2450248350502534,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09265353748639224,0.12009018656452489,0.44131089002755786,-0.1441664093351841,0.3294734843079686,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14189223094056302,0.1652778914373185,0.9321782450874811,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1140221183582241,0.0794029985424859,0.1525824464855593,-0.27060621927642564,0.04256198255997745,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05155537174910784,0.02947006865418306,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07373470029789134,0.126109664220863,0.5594237389366834,-0.17495576166941437,0.322425162265197,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12109153310469123,0.07953642742971338,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13051553092621723,0.0722684817816217,0.0724399400575673,-0.27303024009609567,0.011999178243661202,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.04274037253059484,-0.007669615682607771,0.6229991811234771,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04367213968179863,0.15230536185553234,0.7746107316267486,-0.25667669586512704,0.34402097522872427,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10997022971867393,0.06555964389965574,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04036072063833069,0.12585927161008909,0.7487900823656106,-0.2078359627242084,0.28855740400086977,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11788548984105038,0.07474253028075532,0.9640825891897521,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03214957237451812,0.11988084894822978,0.788840428588069,-0.20425755700895618,0.2685567017579924,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12383459645140996,0.10718678564308949,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043559581932583954,0.1467173672090187,0.766858262782022,-0.2457696305053746,0.33288879437054253,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18889701044559207,0.16731474587545095,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001750413045186955,0.12391275663804759,0.9887435429586686,-0.24260770877162094,0.24610853486199483,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19298043408863869,0.15584486236384684,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09652374213303809,0.1305096607994852,0.4604242919244903,-0.16084358998971993,0.35389107425579613,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.21367433928713228,0.27902878300711237,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03690142097454302,0.056317408798881974,0.5130737629444782,-0.14796033543225467,0.07415749348316865,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11084729471515418,0.020689758014659655,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028456121644666665,0.10030122910080301,0.7769316668721227,-0.1693396551903386,0.22625189847967192,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1504000737192824,0.17030536713382563,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10881715414115666,0.15556467838961763,0.4850619211828403,-0.19795911057677817,0.4155934188590915,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22102342193026014,0.23668346380554492,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04197608487158148,0.11844339639406312,0.7234178941148125,-0.1915963629515192,0.27554853269468216,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19197405018980016,0.2433181072225036,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042616143721031674,0.12792136488452474,0.7393786221001896,-0.20964702361961823,0.2948793110616816,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17048575241338565,0.15369141646831266,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015333025172784178,0.1384346680800062,0.9119188470508988,-0.2576625598191221,0.28832861016469047,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1846488330310759,0.14418970678717621,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02852604754777071,0.10391246134503859,0.783971257194583,-0.17639114238938444,0.23344323748492588,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09340287051578611,0.10251358799754663,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11038338619883047,0.11926485920544264,0.35581616700860785,-0.12480900064570118,0.3455757730433621,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.25277209602835304,0.2813201398799772,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0879863667712786,0.11683953215667102,0.4523124726105534,-0.1424232327436121,0.3183959662861693,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14451995557569672,0.19033893462760765,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09295064020547102,0.15906498681003553,0.5596457703040847,-0.2207282938953371,0.4066295743062791,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.22173401661868306,0.27307191914586343,0.9504142279939255,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027517058417911352,0.12162261140428501,0.8212407409525957,-0.21232485697113876,0.26735897380696144,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11872126859819496,0.10157829539178037,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16006769440133378,0.1255328471958542,0.20376586203597052,-0.08748527431114242,0.40762066311380996,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1949033608962838,0.3610694763810857,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023070582347141683,0.11981766078465197,0.8475107672607942,-0.21321193887336495,0.2593531035676483,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18774931556562338,0.14776997963315544,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14165676871058633,0.05222513888825349,0.007267279427271149,-0.24464565538052485,-0.03866788204064779,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.026575995079436393,-0.06346491185799172,0.1672106205613866,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15304572296855462,0.27099952834755314,0.5728862379232098,-0.38137008341756234,0.6874615293546715,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2911492949089512,0.19513007624502476,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00018581651125312206,0.10116502991230632,0.9985363226431434,-0.19968502364391003,0.19931339062140377,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15431390356018762,0.11860705658248216,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09403746510476768,0.1348141388064501,0.48628683814132145,-0.17181837288067675,0.3598933030902121,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.274173243483055,0.3557460046793641,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07533667693698544,0.06361863795910166,0.2377567062036743,-0.2007937429083208,0.05012038903434994,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,-0.03710681885605739,-0.1295834481565643,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010656351854677079,0.14066439700600417,0.939688694883206,-0.266736297550129,0.28804900125948313,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09831778998843421,0.06038282744241504,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030379501453372305,0.06053616371516969,0.6163372630554189,-0.08899887143395642,0.14975787434070104,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1229408100303131,0.14405665855743352,0.9561867293882707,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061510113272216865,0.18410032007009414,0.7386487091912467,-0.301538935580823,0.4245591621252568,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.109013534494645,0.10776726545185251,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020922363526920763,0.060108389422967416,0.7281519422767653,-0.09761243097961705,0.13945715803345857,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11672859752831902,0.1326310188245185,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07558387588735078,0.16083651319734318,0.6389134330056478,-0.241588539211672,0.39275629098637355,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1680081680092833,0.15431423560365023,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02749571742171319,0.1275844883427157,0.829591645805398,-0.22410312349061706,0.27909455833404345,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.16350526033082083,0.11264540367704655,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05661545422990478,0.12425751871589137,0.6491553387355933,-0.1884225444301054,0.30165345288991496,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.20129037208495312,0.24100152047788637,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0544674220136897,0.1237418429891712,0.6602942551945381,-0.18955365510033356,0.29848849912771297,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14441610643368014,0.14128500115626258,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05275980314117245,0.07950883877892859,0.5077364476839176,-0.10403301657315212,0.20955262285549703,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08555918092845576,0.1028707545131241,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024475690753902955,0.1698134458474644,0.8855421830958528,-0.3103993924284966,0.3593507739363025,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19283249094881624,0.21218024048666292,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05498838881827883,0.1192407501819609,0.6451940472549204,-0.1801564546105733,0.29013323224713095,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.17319612431419432,0.17996652827853135,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0515009200868618,0.09642378315941322,0.5938644967899068,-0.2416503057560903,0.1386484655823667,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1412421556458098,0.08536469971239068,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010630188739090088,0.14288999044769277,0.940771817011306,-0.2711513698312784,0.2924117473094586,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.218846132040539,0.19290171383196095,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03402120016439154,0.11709799857794734,0.7717101871786659,-0.26494049997947233,0.19689809965068925,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.10609447827692087,0.13222164837675424,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07927808809699546,0.15232156865706628,0.6033208119059259,-0.37965888373980583,0.22110270754581493,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1524041267417053,0.012027644383751876,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04034542148490214,0.1291298668276628,0.7550344551048149,-0.2143009328096123,0.2949917757794166,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09938856267025437,0.11973590810037626,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06943826547177297,0.1292887084941843,0.5918159854390164,-0.1855213273653301,0.324397858308876,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1860372243068824,0.20953557861323757,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04953110698357415,0.10793832387614256,0.646821218693419,-0.26238736819542297,0.16332515422827465,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.03882462071562142,0.0029496636138386157,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21704925710942724,0.2644876914932672,0.4128380824132297,-0.304525093187235,0.7386236074060895,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2756196201519482,0.31334503591783697,0.9262602312595302,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11496690561951413,0.12640498800455532,0.36418549994482563,-0.1343059400108529,0.3642397512498811,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18679059228989414,0.24147476961847306,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08945560986568309,0.12878153435438633,0.48810104022277634,-0.164503826703433,0.34341504643479914,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18272342970143132,0.18604486605770545,0.9404802865694325,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.062277661180078714,0.0932415327277571,0.5049639835958804,-0.2461515933792369,0.12159627101907947,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11129443248993269,0.004952541977204471,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07421318908021561,0.13093602696069254,0.5714990299944676,-0.1839949445644002,0.33242132272483144,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1879077361638608,0.2018161058031209,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0328513843816442,0.10804110572078815,0.7613986275480461,-0.2459103331875381,0.1802075644242497,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.13395892275576016,0.045435911838914766,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04814600961354658,0.09000049288401535,0.593282798069233,-0.22562855459449,0.1293365353673968,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12330534654683889,0.014756823071407818,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08263714358968652,0.16209541497713423,0.6107554647094413,-0.23701784782196036,0.40229213500133343,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.128825580303219,0.222947373234355,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06338776400563002,0.16965474678843595,0.7090808440554313,-0.2711743618586496,0.39794988986990965,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15875409753973904,0.11788364133829453,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06135738692470773,0.11988162984127906,0.6093498512338154,-0.1750512823935081,0.2977660562429235,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19876799777785098,0.20103506113567937,0.95480045777616,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14454446634916915,0.09864054335003315,0.1444073247867566,-0.3390653418584666,0.04997640916012827,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08905355212766698,-0.06995092317940414,0.7635967032883216,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07687284781899781,0.21080738596974585,0.715755006602522,-0.33884300176981696,0.4925886974078125,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2263434889012042,0.2591435603556565,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05523088437926169,0.124382611481107,0.6574983940733006,-0.3005155681586277,0.19005379940010428,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1668982787189242,0.09353811170070125,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04648740028304792,0.1270219090490993,0.7147711816505944,-0.2040020244296033,0.29697682499569916,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18469525804884257,0.1294449876743626,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0733418742101791,0.16197174139862763,0.6511837740550093,-0.24606923074310652,0.39275297916346474,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2041103303474291,0.26375148530359743,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055268304851265986,0.06224391726900012,0.375655209986439,-0.06747778789204928,0.17801439759458124,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1852759418607021,0.17041632225667225,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08725590444725437,0.09127769953673696,0.340268783197904,-0.26725712327017054,0.0927453143756618,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09784439126739794,0.0939921676761662,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.062302223008758456,0.22145130414962383,0.7787464979675085,-0.3744036192634096,0.49900806528092656,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2324839841535038,0.21021217207649542,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052941855538797426,0.1540031204734066,0.7313830525791043,-0.2507549896757194,0.3566387007533143,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.14933857767499473,0.11359294948619765,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02308243770043538,0.1174972689587828,0.8444587918708581,-0.20862423028403435,0.2547891056849051,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11193825782413225,0.05599852309123249,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039188601704858085,0.19513382088968392,0.8410381439643955,-0.34561870360610747,0.4239959070158237,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.19011201231852703,0.08594567169241552,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004754838069163643,0.10898957039878461,0.9965235089308546,-0.21445385392109464,0.21540482153492738,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09115846756363512,0.01829874768198055,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07387197250548089,0.19011491356735655,0.6980155682340865,-0.3010379598462266,0.4487819048571884,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.2010573044521066,0.12692392156933446,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028280776456252536,0.11502637524429513,0.8060426452820592,-0.19855324593737755,0.25511479884988264,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1177835330568516,0.07393268135237538,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020677833324420636,0.18679236855951906,0.9119667208217995,-0.3476799822009416,0.38903564884978287,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.18247089065624908,0.0835944211107497,0.9892383067683398,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05830072966010459,0.1251495706420591,0.6418360401222802,-0.1884964109894437,0.3050978703096529,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.132337422544808,0.12623763797189044,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0004776970496259014,0.1099281966574197,0.996537149089181,-0.21630262806556733,0.21725802216481915,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.12739149085105064,0.06928298559714781,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004955322225678491,0.14710682599107594,0.9731621175015974,-0.2851419097373928,0.2950525541887498,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.15919129140860314,0.09515692271250431,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020145101418241964,0.07482601629386462,0.7880361961872017,-0.16770331334642685,0.12741311050994292,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1012611959308935,0.03297874740675428,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020474172286458543,0.11392660505759965,0.857561116589646,-0.20419108407740744,0.2451394286503245,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09409184795095163,0.05762827964681802,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11974837837554457,0.2790026274197246,0.6682431494738537,-0.43044967925773076,0.6699464360088199,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.24057302478331136,0.12738489698704528,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06642600914205683,0.07169320431624404,0.35529782292399215,-0.07495424281149289,0.20780626109560657,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.05944262162914117,0.05493206079380894,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008262622646564107,0.13882091111354572,0.9525979543742406,-0.26549464035817366,0.2820198856513019,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.09916070242323542,0.055464023485341185,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06932209980757689,0.11626941920616259,0.5517095746515213,-0.15996322700457175,0.2986074266197255,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.123403906872634,0.1260095698457662,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02097788670443675,0.10179772268056674,0.8369446689273704,-0.22172477503420232,0.1797690016253288,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11498323781797166,0.02003752800105287,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026643253637774224,0.1391631438965535,0.8483665923705848,-0.24778889839654264,0.30107540567209107,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1047068108603052,0.0731174216791362,0.9827413793708789,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016773210700944202,0.11942743784107544,0.8884496955279895,-0.25228620545646613,0.21873978405457772,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.11433951226318011,0.059323580875444155,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04427381118489786,0.08991761094263216,0.6229948543380637,-0.13304528915904112,0.2215929115288368,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.1637025418225421,0.11121670596937623,0.9584620018167673,1.0 +ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03659543945519805,0.10009879050378295,0.7150589023420157,-0.2339920038386916,0.16080112492829549,196,6,202,2,log_other_mut_burden|lin_Uterus,False,198,0.08973525189254826,0.04071029338686575,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.23830788715957335,0.14231691059070056,0.09550937398192479,-0.0422296281698083,0.518845402488955,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12759442927952935,0.2890037448492654,0.6734224093863465,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17687518122623125,0.09605113568232693,0.06695000020609546,-0.012462451505138916,0.3662128139576014,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14139633571697402,0.2545082178402736,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24014627866006844,0.09277192426136632,0.01030462680934321,0.05727268326943105,0.42301987405070585,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.029928425423882028,0.1987821338646141,0.2065609283145616,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22375793960954607,0.1178721773936211,0.05901361138050474,-0.00859370177460378,0.4561095809936959,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.25202178900664873,0.43162639467936187,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14896585285275193,0.0680276637164262,0.029630950879754602,0.014868564811172102,0.28306314089433177,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18399133765396616,0.21710488357456972,0.4097743694834356,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16882501693527807,0.08703131572859009,0.05372831884812266,-0.002732593253183868,0.34038262712374,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.003311040363434904,0.023634970507196606,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.30210235689200926,0.1356320533205023,0.02697401049806749,0.03474214594008446,0.569462567843934,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18821647653468832,0.3740345037375399,0.38930853697029044,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055786946006662966,0.12950948718136973,0.6670836613653679,-0.19950435841136543,0.31107825042469134,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08598469814761854,-0.010423228605353774,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15079898920875462,0.0924308361724402,0.1042738211103542,-0.03140224753821477,0.333000225955724,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1280348460284966,0.2344299402901012,0.686265063428165,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.26326002928851006,0.10845911461318951,0.01604787134625688,0.04946357739731083,0.4770564811797093,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24486916284437774,0.45437055958220834,0.27874836487218185,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2000564494327899,0.061724285795025,0.0013825764413703584,0.07838448718638319,0.32172841167919664,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11346273034916438,0.23917933762256305,0.047510354076181406,0.4540419767923369 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.217461408807055,0.12293865735322314,0.07835497548142357,-0.02487736406718591,0.4598001816812959,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24440123987592427,0.4098048813943173,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11711638087350643,0.06758137722157465,0.0845554454250035,-0.016101179636952484,0.25033394138396536,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13757471391692488,0.20048849792782178,0.6516302746202923,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08503975815174059,0.07065199256434695,0.23006996822727888,-0.054230651561375964,0.22431016786485714,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15247693777685817,0.17636093503238082,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061426068653007385,0.13813824155802326,0.6570111672719008,-0.21087438318936153,0.33372652049537627,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.007028462256547205,0.0029474291925936182,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049310800657580464,0.1520220360607666,0.7459806688608537,-0.2503576231072892,0.34897922442245016,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.17329669622396582,-0.38290750244938915,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18562128777238368,0.07340141499408886,0.012171417753751232,0.040931169791084215,0.3303114057536831,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11782154702255009,0.2926907296961394,0.2300397955458983,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19764733017205405,0.0615691624895134,0.001532659205601899,0.07628114962451417,0.31901351071959394,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14626491446608678,0.2773569396093934,0.05133438301294462,0.49058705610231235 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19002213292886005,0.07427220939652604,0.011211216149920877,0.04361549020704658,0.33642877565067353,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1246264556039927,0.279239967277024,0.22034340329509305,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14750062894876653,0.07772208549125383,0.05908175502328757,-0.005706468222150207,0.30070772611968327,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10636897847345608,0.22592475390803898,0.5670991189538775,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2268695899778874,0.1064180634549127,0.03416818479733736,0.017096492853360207,0.4366426871024146,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11901802370975346,0.29464710150663126,0.4446345097069901,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20729260506612032,0.12224968435111187,0.09142033517038903,-0.033688052505173954,0.4482732626374146,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12944703737562666,0.2337005411370491,0.6648373299485711,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12975342759995068,0.08158482594079307,0.11323221416744593,-0.031067969260147543,0.2905748244600489,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.001592553330098128,0.08206797202785822,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21347202283009675,0.1660167130570568,0.19989930162331232,-0.11378294631494673,0.5407269919751403,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.21747236462883246,0.3194566971995091,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20136435976321757,0.060959625570275955,0.00112178613769642,0.08119970876065342,0.3215290107657817,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11785634261150844,0.2481166370057082,0.03975329625461689,0.3799101388828962 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04824384788483814,0.0658486609728195,0.4645827932568781,-0.08155815287815966,0.17804584864783596,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11352559187137835,0.04637794675759,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16898113144358695,0.06593186366632228,0.011071014715257227,0.039015120115666796,0.29894714277150713,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03512881308910993,0.13587884981484002,0.21861123086993003,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07390717082065851,0.05811457960081741,0.20485558569511259,-0.04064927716543343,0.18846361880675044,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08678287429030501,0.038531035892547416,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14807055622923804,0.06501641815450944,0.02375784730596832,0.01990908666826227,0.2762320257902138,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08147986094436689,0.14666043688353322,0.3634085581572868,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07891602543586052,0.043587439168647255,0.07163062056021684,-0.0070042761866922765,0.1648363270584133,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1519909243033299,0.1789410224386655,0.6193941895501103,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11552329640254974,0.09715360845161494,0.23573879987836854,-0.07598754940750971,0.30703414221260916,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1708434521074332,0.23155491431301925,0.8449482942840995,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3589011427222725,0.14037944691968898,0.011267767080054378,0.08218278874237878,0.6356194967021662,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1611015510353962,0.4362933682124858,0.22034340329509305,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2717562149511228,0.13212972418089658,0.04093581952256207,0.011299854782724494,0.532212575119521,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1867051237816305,0.37017953887943805,0.4881204508760916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060593008328262504,0.08554589754631298,0.47953087864584865,-0.1080365202685496,0.2292225369250746,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06363360031591912,0.07022479206736192,0.9384017168502401,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10856527078321222,0.07760237085434839,0.16327603011009106,-0.04440584285878575,0.2615363844252102,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16419528563508082,0.22053877472168962,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2314081005130023,0.13433756345791556,0.0864216004694736,-0.03340038999922312,0.49621659102522775,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13484987233207882,0.3194071465171288,0.65578639613287,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07777368431055709,0.04660423159912348,0.09663082919455393,-0.01409336987427054,0.16964073849538472,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09726436367976879,0.06650651283730417,0.673446463693037,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2312522750419926,0.15826750076378115,0.14545532104992032,-0.08072731499671507,0.5432318650807003,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09007761631383264,0.24430256527804453,0.7643196110722902,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10807047911896162,0.04250889042003406,0.01172637534827915,0.0242762311385354,0.19186472709938784,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07269960816261385,0.0928468647105934,0.22587028943799292,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07378441861055157,0.026858464623590424,0.006528808251205518,0.02084055621366434,0.1267282810074388,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13972894685494525,0.12954165585797364,0.1556009807507485,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16716287853759063,0.05185215083827776,0.0014646284470919743,0.06495103666807446,0.2693747204071068,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08107818638415548,0.17391259512053614,0.049684703474427744,0.47482157143467474 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12419838950647186,0.07027459622205362,0.07861167392604565,-0.01432809011624342,0.26272486912918713,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15005727356928736,0.23747634338643805,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11704968888105886,0.06772313477719288,0.08538042927869803,-0.01644730653469166,0.2505466842968094,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11730988789552045,0.1724828591224354,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05405385353343638,0.0529829234448178,0.30879038686972,-0.05038698653541254,0.1584946936022853,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15603839849483958,0.11327090430156446,0.8972101357876419,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1349787321603919,0.058133134779746104,0.021188163677058593,0.0203857078899249,0.24957175643085894,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10582696699273862,0.2517187606220076,0.33504311408065957,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07872980142043234,0.060149979643479,0.19198810443300385,-0.03983886175709103,0.19729846459795572,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12205585826332277,0.16844906054718578,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11054564356000664,0.0661950581462464,0.0963954654601298,-0.019939181204348164,0.24103046832436142,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15702409136428758,0.2276624528282298,0.673446463693037,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13761281627405245,0.07283161988505178,0.06019427208005911,-0.00595411189464759,0.2811797444427525,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09018375971422136,0.22613605617458807,0.5695790344215832,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02395516167647988,0.05528163106642751,0.6652159841911792,-0.08501692996295532,0.1329272533159151,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09493347650445662,0.09690813050324654,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08648448493173244,0.06507922286143335,0.18530588603216402,-0.04180078633599971,0.2147697561994646,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12763989044568452,0.14082768834485507,0.8064463395412927,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06965859554247715,0.048530869485520454,0.15266220335565422,-0.02600628002103192,0.16532347110598622,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.022803240699317627,-0.0012536331555173437,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12436945924258089,0.04892523428797001,0.01173523018623457,0.027927205071333908,0.22081171341382788,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09340857117611837,0.008923991954683241,0.22587028943799292,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3061484427611747,0.12939439665030436,0.018882313528870924,0.051084006755965305,0.5612128787663841,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11218742117584277,0.32379681167293084,0.3146632024742357,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08799965027889356,0.0352881515447283,0.01340473488062966,0.01843904561262255,0.15756025494516457,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06054251412089507,0.08628308591342575,0.2480344649940285,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09660289835337349,0.08618985421868915,0.2636345662365633,-0.07329600859136903,0.266501805298116,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15817186691708782,0.2021626052086697,0.8672735958499126,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00312007980238967,0.09193496565833978,0.9729586012508138,-0.18434384815594437,0.178103688551165,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.283374745064712,0.15576448048695923,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12062996030777146,0.09130573149860133,0.1878704354410332,-0.059353450965231674,0.3006133715807746,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10425775007958292,0.12237481532590626,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0962888400075291,0.15866238663707383,0.5445807237027754,-0.21646915578262718,0.4090468357976854,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24421767035346326,0.32587539979647423,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13502175561876056,0.0478408864359505,0.005221537283198559,0.040716986380932185,0.22932652485658894,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1709714309948052,0.25545492000473097,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05537131702133488,0.057539091636937656,0.33698262157318915,-0.058050719299841805,0.16879335334251155,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15964538737522596,0.1718724032073757,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07480016044745974,0.0427722529683161,0.08177273346873246,-0.009513232268607508,0.159113553163527,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07333730137134124,0.03081030847888554,0.6428846031996515,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17004656730130127,0.07591468410753321,0.026130703027676703,0.020402250486473844,0.31969088411612867,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09197415146651149,0.31586268562898995,0.37990022094083825,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13546226859579816,0.08836123328563104,0.12675424272442895,-0.03871689770638656,0.3096414348979829,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1513701224616576,0.16785541686615393,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.25251635116044957,0.06428117773772392,0.0001157348547329446,0.12580420001735285,0.3792285023035463,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1488999340345452,0.35344100736852874,0.005436114064320203,0.05195128564764741 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24936152361225822,0.08804260909196798,0.005067230174715926,0.07581043474123089,0.42291261248328554,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07487767596285132,0.24309026915886456,0.1336334655378572,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1313546549984764,0.08136620223665746,0.10793589541363623,-0.029035787096683863,0.29174509709363666,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09171460675625585,0.09557391988506027,0.6967044957001925,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22777935178850686,0.08109723933263274,0.0054386794327308165,0.06791909394550388,0.38763960963150984,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11122828773216765,0.270258777348247,0.13931314813151582,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14800886783955872,0.10750851888978555,0.17005173345926136,-0.06391375358961313,0.35993148926873053,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08262653065014132,0.04013435552397753,0.7842677313995,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1381471319754216,0.07584341487350021,0.06994356745693864,-0.011356697712808866,0.2876509616636521,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08436032279837204,0.06785824174884886,0.6114670027237653,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13446227000565056,0.08315229284279452,0.10735224314522496,-0.02944894427827574,0.2983734842895769,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08700067179487646,0.05920707452851572,0.6950751273138628,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1047595988111055,0.08293806568238977,0.20793835993638807,-0.05872932724968155,0.26824852487189255,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15981448170349769,0.2355053858697489,0.8210381131305959,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037852193580399436,0.06786747213758756,0.5776125137710155,-0.09592932209570706,0.17163370925650592,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16338238356980694,0.1332399132477928,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09806484338059357,0.07945107249647111,0.218465145200978,-0.0585504623894785,0.2546801491506656,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11706552620538871,0.15888795086341753,0.8332532350933084,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21086703958266212,0.08038847581346775,0.009346196413017158,0.05240390844650919,0.369330170718815,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1962568527363638,0.35639952178115575,0.1983417068376634,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11647253572814088,0.05916750695394335,0.050311216973618976,-0.00015946056940796538,0.23310453202568973,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08530451474133145,0.07548212913741022,0.5275612089369318,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1661661599043346,0.07483343450253484,0.027444771881363322,0.018653220705688617,0.31367909910298053,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.22732052655450138,0.3418567133934307,0.39228691037577734,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10902774608945848,0.0641220538283076,0.09053799612513172,-0.01737073729629396,0.2354262294752109,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14149287958367457,0.22670071376703074,0.6632964530955446,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11842201480572388,0.07036033897639729,0.09383180939332798,-0.020273482393056194,0.25711751200450395,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.17398772938577822,0.2540661858888578,0.6707240267079618,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14012084644032866,0.10381573437996493,0.17854936162958693,-0.06452249533941831,0.3447641882200756,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1369072338652258,0.23825487934223336,0.796509803908465,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1459665493075612,0.06963002138462643,0.03724035457684279,0.008710666570241499,0.2832224320448809,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07764875309027938,0.1837787422663668,0.4631727895701855,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14304610981604715,0.07141702031416243,0.04645412822448705,0.0022676643874245395,0.28382455524466976,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15580290114458703,0.26057376404354454,0.5160097508806438,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016359971399990368,0.08814424097674292,0.8529323508891914,-0.15739145597132245,0.1901113987713032,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1229141261674975,0.09450307124538511,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08029283601752313,0.04509215982282874,0.07640353756365066,-0.008593596557681604,0.16917926859272786,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11469805429227721,0.13454323690535253,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011018586949839804,0.08796884327616286,0.9004399266405377,-0.16238709349012814,0.18442426738980777,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10703276724241108,0.0853856157574439,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15575435161122125,0.04975504490043409,0.0019915306084857566,0.05767636064349384,0.25383234257894866,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10538507889467345,0.20101332069714847,0.06374504020225781,0.6091919251481692 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09793916968137516,0.06380809884453502,0.12629896468805962,-0.027840440299191152,0.22371877966194148,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0902748878457662,0.14578027804271068,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08142296977663732,0.08674587777013197,0.3489848356930121,-0.08957198025208557,0.2524179198053602,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1643430725335709,0.2648399515210527,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22387764008200126,0.07097919686870512,0.0018433314556921738,0.08396223967755562,0.3637930404864469,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12346485085959594,0.2873665063121681,0.06021549421927768,0.575461129694149 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11567219394184391,0.03621703273183128,0.0016176420275150732,0.04428056287692156,0.18706382500676627,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1675206826763995,0.22742071016032894,0.053503510060061044,0.51131674232623 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1510619678898213,0.049608112127581094,0.0026207694193088648,0.05327361330364225,0.24885032247600034,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.04098930600897466,0.10773344308923129,0.0785044062282029,0.7502426888590925 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19639445433385616,0.05769964335985012,0.0007947324477512452,0.08265593572508086,0.3101329729426315,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16914679880353956,0.3232473652579813,0.03004088652499707,0.28709159861307076 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11071893522545662,0.05472713737380446,0.04431749639313494,0.0028398709862694355,0.2185979994646438,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14240454105154227,0.19463244866756002,0.5034452685637203,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12338633698156379,0.044775210285559294,0.0063668441773957404,0.035124680726343185,0.2116479932367844,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10214276384346843,0.14865836214604541,0.15361704887588873,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07660673126811537,0.07637271758308903,0.31697344377033865,-0.07394046892604328,0.22715393146227403,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12916224796953088,0.1467648522174411,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12739412332573097,0.048757351456092196,0.00962281124536637,0.03128280264879593,0.223505444002666,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1691622576635582,0.23100425859021465,0.1991607712674163,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06368461161185951,0.047506389387639604,0.18150188774517284,-0.029960791353692007,0.15733001457741103,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0004970641474803449,-0.07510776871070401,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16113507593061321,0.057128757898071286,0.005249034694861685,0.04852189645631154,0.2737482554049149,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.011098213928593306,0.016036465769381475,0.13594586142399853,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10715205686954316,0.09068672255219835,0.2387029441237025,-0.07161115343739224,0.2859152671764785,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1806338804845171,0.23782798126733815,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14420668847288887,0.04681217226640912,0.0023400000030462447,0.05192973810710762,0.23648363883867013,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12433286005436804,0.20423799461843606,0.07171783793120112,0.6853855236132604 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08719322162748334,0.06213935553664267,0.1620235884237415,-0.035296933154993215,0.2096833764099599,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.052336802168810204,0.033865965366917904,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030404454173678888,0.08428108479246818,0.7186450765776771,-0.13573185400506915,0.1965407623524269,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.140515396226328,0.11698787591375803,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07289561223639994,0.06541572353169671,0.26639340576627263,-0.05605297487728848,0.20184419935008835,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08571496767946031,0.17074755126694083,0.8699728633396779,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1184131283464989,0.06821690049341671,0.084046355204546,-0.016057186449283986,0.2528834431422818,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07827714897084079,0.09824444214017658,0.6508877732816449,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09240416417967597,0.10952890967045034,0.3998154225828884,-0.12350108592833346,0.3083094142876854,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.030494291648605256,-0.049114288572500886,0.921525791075194,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08961929797486143,0.059657817849467554,0.13452777757721612,-0.027979207501381415,0.20721780345110427,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09690306783453563,0.09972679698638638,0.7462484265604064,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18171081486455198,0.08732962383370613,0.03865851565905004,0.009565174664304954,0.353856455064799,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.03342939438745178,0.036117401925160726,0.47356681682336305,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07519127039181464,0.051116996167308734,0.1427835219009502,-0.0255714220834347,0.175953962867064,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0651776091239687,0.03126301184853144,0.7607934302264618,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15124893421561852,0.0808495770280406,0.0627583139571145,-0.008123127479206071,0.3106209959104431,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.040377794190700846,-0.0014514841899599118,0.5817074626033015,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.056291544621684744,0.03612083412802574,0.12062451811461736,-0.014910458118832959,0.12749354736220245,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10398725395205297,0.12706318114995394,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03779897342257621,0.06286530176832068,0.5483030284398533,-0.08612217892197774,0.16172012576713016,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08178522154922062,0.04578158143391899,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058050006517209395,0.04908153328211664,0.2382424680462718,-0.03870034689034326,0.15480035992476204,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09628161855991217,0.0901873296430578,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0673732719352529,0.08666391728276684,0.4377843974517124,-0.10346011618641927,0.2382066600569251,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15267671228058768,0.137791854099558,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24244296117257866,0.09866782501450043,0.014807033057348337,0.04794726591308038,0.43693865643207697,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1398407267265988,0.2745839440273922,0.2647257396604304,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13556268842266772,0.07034077471504568,0.05528781636859767,-0.003094243371298183,0.2742196202166336,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16658779536976467,0.2027007370477625,0.5504031566140049,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10644009986514616,0.07403767575112453,0.15200840775021202,-0.03950422614483742,0.25238442587512977,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.052332700056960814,0.0485001881481121,0.7692078902000675,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11051195828771243,0.06255014878583527,0.07870506906111407,-0.012787959136211655,0.23381187571163653,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10983846272502895,0.14273743905526384,0.6337247675321748,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09827261940491648,0.07908674396749094,0.21539058207257003,-0.057624515770674,0.25416975458050695,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1590535387499687,0.12290305257612712,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12434784595784143,0.07221609668921296,0.08654885446853806,-0.018005752415604398,0.2667014443312873,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15304454357935138,0.20526263591143593,0.65578639613287,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1208374904466175,0.06547517944929122,0.06635261508092068,-0.008228297183329777,0.24990327807656476,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1436778237016091,0.19555172419624114,0.5971735357282861,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11723407246019037,0.06875085857166718,0.08962161002882323,-0.018288789583426265,0.252756934503807,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16218293860237182,0.21833080580635134,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15757640542539467,0.05851109542038323,0.007645243608893151,0.042238338710030965,0.27291447214075837,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.02908374779146819,0.07284737786187645,0.17308879679374334,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1374903989527829,0.04298885620935933,0.0015941933806925418,0.05275003424299862,0.22223076366256717,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.22248320262051655,0.26911179544586844,0.05294856508760417,0.5060133023244723 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21225895649652815,0.034548461786865624,3.9312508250199176e-09,0.1441564408649621,0.2803614721280942,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11026818914260712,0.2384700641211274,6.783971532393066e-07,6.483234875773957e-06 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18873112293260075,0.13017604806974464,0.1485880005634359,-0.0678741176484901,0.4453363635136916,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18166703322475,0.28412526456299864,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.23582510582008304,0.06949785985695683,0.0008240845883669758,0.09882974213450971,0.3728204695056564,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08087582259820644,0.22447741645482902,0.031002765224914946,0.2962839802493951 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09628194350744153,0.07300134512017,0.18862327458949923,-0.04761954993218191,0.24018343694706495,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16467912086199696,0.20268408614805203,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0945703029716082,0.05822770992962328,0.10583050951795256,-0.02020914944326077,0.20934975538647718,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12941835051232486,0.1081511385153366,0.688943585244993,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16856084336070523,0.08747868514059401,0.055331534262783554,-0.00387862902359154,0.341000315745002,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.04429799620354051,0.03571941970576145,0.5504031566140049,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06265247767221357,0.08785556449404246,0.4765492812241948,-0.23583486104970527,0.11052990570527813,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.24843799636644473,0.04811408091528585,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.23156737766228774,0.09731713237591101,0.01822224097501494,0.039734190710697614,0.42340056461387787,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11662059323566251,0.2680622049586803,0.30645794249929786,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.33247668642266515,0.13415958077285012,0.013984821504747393,0.06801903840717932,0.596934334438151,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.23793601467149816,0.4843203857015565,0.2569710951497334,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035786970113235644,0.07726595013252158,0.6437204123976582,-0.1880949255049956,0.11652098527852431,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03054875272552381,0.10358342077469813,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06690397392591604,0.07973128592011627,0.40234817215772456,-0.09026369331198916,0.22407164116382125,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07201037073346844,0.08930899775233779,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08334364856357318,0.07624337726321255,0.27557887326438035,-0.06694859379163681,0.23363589091878317,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11302400883574727,0.1636196832549537,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06786006421779633,0.05751240338925828,0.23935413351602192,-0.04550936377551973,0.1812294922111124,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09393454164527146,0.1257582051843716,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06419356675333601,0.07207083605643497,0.3740993004640236,-0.07787369138952466,0.20626082489619668,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09170951593043279,0.09752401158829242,0.915842680969123,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04516394575762021,0.07098622597155456,0.5253093359154614,-0.09476531053394521,0.1850932020491856,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.12663915962007544,0.08446269788640369,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021916707171015362,0.08455502959518504,0.7957320468982635,-0.14475960566334672,0.18859302000537742,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14119968537369776,0.09745677450682634,0.9735235918682278,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1502069375716917,0.05981556345189843,0.012779389218458797,0.0322974812802828,0.2681163938631006,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.17445375503568022,0.2498477316407864,0.23981747426980124,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1815690765604142,0.0689453799326699,0.009073161823236033,0.04566277070068542,0.317475382420143,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13472744375381554,0.27299985346664396,0.19636616606057228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.186357896831872,0.07913099976554429,0.019433192913850206,0.03037352387425496,0.34234226978948906,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06384987624125725,0.2070468966012131,0.3180632687631813,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20690754322563376,0.08015904789539736,0.010519753986702532,0.04889666430473419,0.36491842214653336,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16462260233437495,0.29404900356396835,0.2092877372091346,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07384952733570352,0.06611197651105129,0.2652428405253432,-0.05647152549592452,0.20417058016733156,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1362359131301792,0.1250801048247038,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17419136685941355,0.08525925251648299,0.04228182523075879,0.006126877821964111,0.342255855896863,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.055625031969935484,0.07492604579737407,0.4935781304143577,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09918490089697182,0.06625438676714508,0.13587239955934402,-0.03141687345422933,0.22978667524817298,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18701618647950743,0.19616731254943331,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2802341837636123,0.0840518179715933,0.0010101069341321523,0.11454981024258518,0.44591855728463947,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.021765307652689584,0.18044258950600156,0.03644649474155011,0.34830804445427466 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2655287700833022,0.09985849757911601,0.008434286968431293,0.06868600080806189,0.4623715393585426,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11123262341149584,0.2753828851111648,0.1877705709914981,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18501034964500454,0.07252906837242902,0.011451389756065319,0.042039816165158034,0.3279808831248511,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10144802866567496,0.27615556975423644,0.22274190244438216,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19974984375463667,0.10651047480352113,0.06211224977728624,-0.010205416192419797,0.4097051037016931,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.2122145597252499,0.42324007866137964,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061432899812703945,0.09033437117926821,0.4972076685203446,-0.1166357494735176,0.2395015490989255,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.05623272155177219,0.13741531144798072,0.9438001947036577,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07172594697272902,0.2983124242921201,0.8102222774659563,-0.5163125788457487,0.6597644727912068,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16935763700590234,0.003194424162155244,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0926596698136916,0.07806297742386444,0.23656146345734166,-0.06121939933422689,0.2465387389616101,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.2052968782000126,0.2954795017842424,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10301791853192516,0.06585181720495632,0.1192174937237606,-0.0267903038495563,0.23282614091340662,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.20121693647432395,0.29507238092636673,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11690585141506774,0.08551420926803077,0.17304407278563555,-0.05166121270849619,0.28547291553863163,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03682028457512035,0.0077889131271867695,0.7862758155537349,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13923422960925996,0.07564001900950867,0.06705604940142063,-0.00986866269158887,0.2883371219101088,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.18608886945528846,0.300636497088881,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0761648607288649,0.086293191595099,0.3784365439745526,-0.0939377466102886,0.2462674680680184,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0827700426018416,0.05007890071725026,0.917821352297586,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08756349739849292,0.08769537585594381,0.31917712808854887,-0.08530311941036214,0.26043011420734796,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.05721055214142183,0.007596134225807451,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15494812667807156,0.09533103699859369,0.10556958060358711,-0.03297003527721162,0.3428662886333548,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.13680157723314676,0.3062330948133067,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051134104800304524,0.07976527584072363,0.5221779064330947,-0.10610056394735695,0.208368773547966,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.16602872307338748,0.19436732953650837,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11827257247151854,0.04348213479359188,0.007069244329432579,0.03255984862457044,0.20398529631846662,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1539271205545013,0.1714555826929609,0.16360251162401113,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15613327190312196,0.05931319760646989,0.009103394949646083,0.03921408771274386,0.27305245609350004,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.037957849250501,0.10343418995120846,0.19636616606057228,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3306786488250715,0.09223242771379843,0.00041792020495996394,0.14886851820720978,0.5124887794429331,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1820539717652883,0.4020318262593765,0.01746026624722207,0.1668624441210733 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15454399604273988,0.08674040196609736,0.0762322334770754,-0.016440159987912623,0.32552815207339236,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09564314767203523,0.11398594038134167,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11209449335231528,0.06553078783346587,0.08862480034763205,-0.017080910470557265,0.24126989717518782,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15833882422614778,0.16882013834778195,0.6599471530576952,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1629678365876024,0.0817949497949485,0.047610577817458775,0.0017322400114512526,0.32420343316375355,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14921256456489676,0.1997916893309696,0.5170078888029929,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14528643570623068,0.04946987143196617,0.0036816819718957887,0.04777058353107398,0.24280228788138736,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14909889394658915,0.200128815965674,0.10218598424093975,0.9765603137966754 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22910757270527773,0.16362667973679418,0.16291979767359482,-0.09343612209831223,0.5516512675088677,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,-0.022004482899004457,0.036761629083094494,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21442880521095925,0.08409570032436987,0.011484091065524834,0.048657930049588405,0.3801996803723301,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.22338373516113327,0.38199710889149446,0.22274190244438216,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04664042557058741,0.03742437353343158,0.21404504575230854,-0.12041198736356525,0.027131136222390426,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.10659176799989074,-0.03845641121321204,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17784967258433032,0.06778083262752976,0.00932516281446093,0.04423894218440841,0.31146040298425226,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08070188442891968,0.19524831680290108,0.1983417068376634,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03905043927980932,0.07346715966085379,0.595603911116408,-0.18387015426672,0.10576927570710133,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.14758352395790664,0.004742545932897642,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24466306752030054,0.10794202146915616,0.024422880428374167,0.03188591843169078,0.4574402166089103,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.06907008392129707,0.2619006309358749,0.3691320687802387,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17655568361698754,0.08327285361981286,0.03515108418500934,-0.34070454935561817,-0.012406817878356902,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15320083340211396,-0.1444074233893024,0.4493241481738629,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13068576639020124,0.07142959467410273,0.06871809572947156,-0.01011746583065759,0.2714889986110601,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0881313437470271,0.15736725409083932,0.6034358143668586,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06533477719331132,0.06428976351561348,0.3106664800661704,-0.19206385276784987,0.06139429838122723,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1369974911263818,-0.032513176162833946,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13612073200559816,0.07189668831010626,0.05968234359037534,-0.005603243137002806,0.2778447071481991,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.11382660499806925,0.2093042092176627,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013142055472063825,0.05816482174839591,0.8214618129892387,-0.1015134306900817,0.12779754163420934,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09188166379618506,0.02633130194896677,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2141004284921208,0.14960936769947927,0.153884585443779,-0.08081210235334774,0.5090129593375894,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.15100857109297655,0.3372263467915774,0.7711789647234355,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023916070776007922,0.06482844533149805,0.7125605721323715,-0.15170700511036733,0.1038748635583515,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07462453376535513,-0.005936594102734029,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08114572347874278,0.04902908834120166,0.09939342834465098,-0.015501249569056297,0.17779269652654187,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.0873497089830583,0.1435470690049261,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011016633862989861,0.09464487545837852,0.9074459726729428,-0.19758222251684615,0.1755489547908664,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.19287557155569768,0.050360590656881664,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06687885512423931,0.07621310056829009,0.38119523952836676,-0.08335370529485585,0.21711141554333446,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.03745986797027291,0.054624946527555014,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01836390625304316,0.05541518913423473,0.7406790781900476,-0.09087145732181642,0.12759926982790273,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08750135423447115,0.06649903800970806,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16009728940686543,0.07517082768611737,0.034342672046544995,0.01191927502482451,0.30827530378890633,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.09300535081029258,0.193652976770366,0.44600863216872333,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002292442509221308,0.06297259101004601,0.9709946275590022,-0.12184020021388478,0.1264250852323274,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.07653265689286105,-0.015045315318521463,0.9972922369220661,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13838346475609722,0.08761466889463645,0.11572249839606807,-0.03432406111759789,0.31109099062979234,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.08198302317468113,0.16935321078485574,0.7154246045700844,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005202371855293906,0.05114761466958678,0.9190807037201446,-0.09562067633254462,0.10602542004313242,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1006203547695243,0.06680142902381402,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20142392386770636,0.13223874940483135,0.12920298305056915,-0.05924734867690884,0.46209519641232155,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.1071715886252657,0.19129558066355376,0.731539728822366,1.0 +ENTREZ:7157,ENTREZ:3717,TP53,JAK2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021008476765528823,0.07443907303997709,0.7780472520865319,-0.12572709040903074,0.1677440439400884,210,6,216,2,log_other_mut_burden|lin_Myeloid,False,212,0.054238294073187615,0.018262698122749017,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01992949547211409,0.07455143021101078,0.7893429919811169,-0.16644791204963372,0.12658892110540554,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05386640281729616,0.04812382022864072,0.9727286373504853,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0487886352611914,0.09404709392634272,0.6041814786818105,-0.23362253109394812,0.13604526057156532,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.005593542971741673,-0.06140063398015494,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005338416144894929,0.05228451657715034,0.9187209646991963,-0.10809492341407022,0.09741809112428036,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04199687947982514,-0.03058415722261654,0.9901822239590808,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12258535367726109,0.10040132650524682,0.22275304363061427,-0.0747367277394767,0.3199074350939989,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.1267671455834893,0.2439606062946997,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06343922011175394,0.07397789528370904,0.3916085916022982,-0.08195200911117966,0.20883044933468753,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08113092407233745,0.13127747287407535,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04931182905131223,0.06235409507636369,0.4294631886857072,-0.17185841537238306,0.07323475726975862,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04516181353808219,-0.06398394298270553,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07337744142252146,0.08080187693007845,0.3643109125154771,-0.08542518692112856,0.2321800697661715,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0667637581832432,0.1266969342153839,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01807080193677413,0.055934971474833776,0.7467961456860939,-0.1280016701790704,0.09186006630552215,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.006934733223479033,0.0040074099845123475,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019679535319853725,0.04758458283654267,0.6793894958273172,-0.07384003514282435,0.1131991057825318,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04747252295250844,0.058136800023040704,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04922362415126063,0.09275795432024644,0.595915185536265,-0.1330766825431257,0.23152393084564699,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.11428229315838744,0.14033126269198648,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0002382454412657737,0.062033299820749226,0.9969373764338532,-0.12167787124608809,0.12215436212861963,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04138448325365706,0.05983976172071373,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0855078381497308,0.09116727317051947,0.34879529298450873,-0.0936662497360017,0.2646819260354633,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.12420713445019957,0.1861390011439732,0.9086977961712401,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022122916341648306,0.07671448916038962,0.773190835068593,-0.12864663225748088,0.1728924649407775,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.052906879515409296,0.07569963357553243,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007007339643013608,0.055399581494004486,0.9899137424824352,-0.10817791446114437,0.10957938238974708,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03349061094911869,0.018235346171035987,0.9991191172759399,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15520384579125932,0.088550709615484,0.08034328273757829,-0.32923551390217143,0.018827822319652826,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0772052458055321,-0.2061133253771246,0.6387525418536338,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03323613356479058,0.09887668551078374,0.7369265497100805,-0.2275617870964345,0.16108951996685333,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.20086105199941942,-0.16248226705978036,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04691690153971958,0.05046017094272899,0.3529909178917481,-0.1460879613816764,0.05225415830223724,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03427568296383212,-0.038789863906054926,0.9092831415853414,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026159828151939412,0.05599818086951024,0.6406186968207384,-0.08389526762555781,0.13621492392943663,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05053973475298157,0.09656014538165629,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02162673270798449,0.058435571871868625,0.7114883278845008,-0.13647211445632146,0.09321864904035249,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.050956509605683625,0.017971548903560456,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0022334810672688457,0.05921136814352818,0.9699275408848542,-0.1186035611478655,0.11413659901332782,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.014224510820397399,0.028103837416301108,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07205858583599085,0.09205594218901146,0.434180699493389,-0.2529792046344424,0.10886203296246068,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.015538490756099895,-0.06289010166491515,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05040250876964521,0.08559584043308777,0.5562667421034385,-0.11782185621411025,0.21862687375340067,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.02135519783462739,0.0876190727399239,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0670731839970741,0.04131551222195935,0.10520707230268801,-0.1482719405295354,0.014125572535387196,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.08792011334519742,-0.1507311420040169,0.6885877821127975,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0735955332791266,0.07574897613745751,0.33179402806379166,-0.07527646031797808,0.22246752687623128,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08715423825344348,0.14485553361730702,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023349145937244666,0.062297709852665736,0.7079889982067789,-0.09908662461984671,0.14578491649433606,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.014566250197513168,0.034549776325576535,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006535933696585472,0.052014580928321494,0.9000613967596545,-0.10876192741649306,0.0956900600233221,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04775105549149319,0.06204962807120753,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04024371422412574,0.05459225308469357,0.4614098493002249,-0.14753569315368817,0.0670482647054367,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04864320942080799,-0.07775418894435997,0.936984237335683,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02553741698036893,0.04427566263109065,0.5643795124631974,-0.11255385601133658,0.061479022050598714,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0524537396669949,0.07298483320770408,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06647957183151432,0.06277886332598183,0.29020036370298624,-0.1898609693851839,0.05690182572215527,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0026486909668330724,-0.05941990004429443,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020125893144116565,0.04124962014421668,0.6258585639256353,-0.06094336348648458,0.10119514977471772,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09141314054843244,0.12479161752079933,0.9600126145781049,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04135771136472863,0.055150574867409825,0.4537097735921104,-0.1497469787475479,0.06703155601809063,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05774757085302897,-0.005144129757584753,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07181676612868809,0.08506874186675838,0.39900192081049435,-0.09537167443215191,0.2390052066895281,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.030119521232058764,0.0765272740909645,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10829533823062171,0.08295430563216528,0.1924064144868461,-0.05473753015447544,0.2713282066157189,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0597174094378885,0.1498549920150433,0.813283143145888,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049153945232957096,0.04308339288046292,0.25452693649085667,-0.13382717668895525,0.03551928622304106,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.018348551237360473,-0.04155076883025718,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006406233833828458,0.0992331531766933,0.9485555286372098,-0.20143246517896735,0.18861999751131042,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06583945840497477,0.03947891968400288,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07077062242024855,0.050270646009615505,0.15989392853434004,-0.1695692025790772,0.028027957738580106,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.054879521046973696,-0.0044867511358983965,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009976722091738804,0.08430178437579845,0.9058476870369134,-0.15570439128785662,0.17565783547133423,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04821242507288164,0.0644337925876315,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038245507510762854,0.058046635879949494,0.5103180150912625,-0.07583548533819681,0.15232650035972253,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06602075713148232,0.1359376036635848,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02135096151146573,0.0567994872498765,0.7071707326023077,-0.13298089149016365,0.0902789684672322,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.013750505913563452,-0.031911454515567116,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017472880328783053,0.03889628619759563,0.6534946733403362,-0.09391705112855442,0.05897129047098831,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04466303557043314,0.010678120107491454,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004472741231016708,0.056940611174945484,0.9374252413577309,-0.11638002677464193,0.10743454431260852,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.012582607655668937,-0.012965447421568849,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010369859375502085,0.051609063605361,0.8408447671737611,-0.11179887635214994,0.09105915760114577,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06079475044816778,0.031467323471489395,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011715744553401765,0.04670923648652629,0.9800006232425946,-0.09062764858008802,0.09297079749076838,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.037786827545984385,0.020399333735812052,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006302403558917334,0.04867400594715791,0.8970351013381286,-0.10196305365881375,0.0893582465409791,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05980753720967797,0.03444164169002772,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049815659441674855,0.0301955551000971,0.09969922849566501,-0.10915999272170959,0.009528673838359883,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.021326868523432265,-0.029093164303395518,0.6779844217208436,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07860936678216313,0.045983270108514135,0.0880547709442589,-0.16898182384014737,0.011763090275821106,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.028282498794313052,-0.06551863450039487,0.659371665428829,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03020270247624817,0.056743938902275366,0.5948106576991985,-0.14172346143152,0.08131805647902365,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05071839558215821,-0.006552856906749474,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05740897305207124,0.031837475560996864,0.07203795925045517,-0.11998022747092718,0.0051622813667847045,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.024941616397790602,-0.04736638669951391,0.620887427285682,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0155042496123889,0.027027638875891435,0.5664996649947702,-0.06862257129603852,0.03761407207126072,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.037786831872988015,0.0031458077567116083,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020221493551946804,0.04591968798558614,0.6598864531101098,-0.11046899053944441,0.07002600343555081,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03364500650215463,0.00824293857133758,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02515272977627313,0.05192360772226842,0.6283286602040243,-0.12719993081488473,0.07689447126233848,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.11803152773331,-0.1826052220499325,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01232945563904716,0.041268647677654376,0.7652626291641005,-0.09343610771682855,0.06877719643873421,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.049198972462470424,0.07703898210487,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044246404682054194,0.09666158009190456,0.6473597099991889,-0.23421863752669259,0.14572582816258423,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0029068184539289724,-0.0435040560638137,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009361624148265538,0.06550689563662838,0.8864258318304967,-0.13810451474635982,0.11938126644982873,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0404923925635496,0.07259629053379597,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007833566370075763,0.05195809568192663,0.9879777768013718,-0.10133162474097253,0.10289833801498767,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08183678234854472,0.08474667485412905,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06173796562238124,0.0931021851242127,0.5075982887681643,-0.12123886937188597,0.24471480061664844,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.12783496448175782,0.14714178498055683,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07905671339586537,0.050177215737663906,0.11584337303092883,-0.1776716719196964,0.01955824512796568,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.019063085807855953,-0.061989306775397345,0.7156145487311385,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09651747616068039,0.07900176059687354,0.22246589944765185,-0.05874732341093945,0.2517822757323002,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.1374163525742138,0.23438779496801543,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.035980744054146994,0.061892841782134785,0.5613074319664884,-0.08565932575717614,0.15762081386547014,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06642759376326939,0.08616137913195591,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007983086362569232,0.06010987082030971,0.8944053379055266,-0.12611902377306655,0.1101528510479281,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07186757996569718,0.04179536357603916,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06303616308261573,0.04302278164814135,0.14358087988930623,-0.14759027325869434,0.021517947093462872,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0005389630016246282,-0.06321490660926377,0.7623712538871658,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026744268750278268,0.044359395638339204,0.5468838928013684,-0.11392527105793433,0.06043673355737779,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.009841713661111064,-0.033122422603905,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012319279950762633,0.05487172818871102,0.8224635995069639,-0.0955219607380655,0.12016052063959078,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.01876832117598058,-0.0038132083310647214,0.9796489133048895,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05399485702561346,0.07029113177831371,0.4428012272931613,-0.08415065270438238,0.1921403667556093,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06420725513036102,0.11947690053014436,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001984371037897706,0.05923054858943879,0.9732889673124442,-0.11839214708966646,0.11442340501387104,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0026885531317478437,0.00799365542715944,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017347815364549015,0.0535168761111833,0.7459729411565986,-0.1225263199994308,0.08783068927033276,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.011351160578172,0.0024393178863823233,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027452330368073655,0.057841042026830346,0.6352940039306307,-0.0862246020124037,0.141129262748551,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03512559269285195,0.05592047528370336,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05269108571492359,0.05580385752097284,0.34557221186719245,-0.16236427132314366,0.05698209989329647,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.021288430296913036,0.005234912716697157,0.9073272983575541,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09499034876927481,0.08035413010435676,0.23778173357773352,-0.06293230777843956,0.2529130053169892,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0012942930515277837,0.10225405639992897,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05394946414235795,0.05606943218562764,0.3364789154648542,-0.1641445925119468,0.0562456642272309,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.011084263050756228,-0.05564183622243085,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005940224598657904,0.060918889015968064,0.922365184914715,-0.11378570330128757,0.12566615249860338,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0919781497800486,0.07674243161436886,0.9911128933864998,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026461801147099933,0.05607337744019916,0.637220666071415,-0.13666468325731024,0.08374108096311036,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08286505522957947,0.040098637277192366,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0100473513291611,0.05437574925030234,0.8534890345656836,-0.0968191253812195,0.1169138280395417,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.01902968150378569,0.01008041144658415,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006376820541076604,0.08701269457558888,0.9416115347199954,-0.1646321352264235,0.17738577630857671,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07250528208593136,0.08274010573641975,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003174409795033175,0.05562237292340573,0.9545145791005765,-0.10614209807013784,0.1124909176602042,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.012603216603348401,-0.019108812835492667,0.9946097045025434,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01232601323983896,0.07332449535865268,0.8665795497807903,-0.13178106728010988,0.15643309375978778,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.10520830443607526,0.08704836530974273,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04587371459626773,0.053060033521243846,0.3877468673397769,-0.15015437122590472,0.05840694203336926,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05349201894184899,-0.014643690489653229,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0009500300827874522,0.0525792045306813,0.9855923006644863,-0.10428569743264285,0.10238563726706795,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09678249790223836,0.07786903602803917,0.998906982267571,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.043349154861125005,0.05796682025069951,0.45496128488825716,-0.15727328338725755,0.07057497366500752,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.027657597912273336,-0.04633036918416425,0.933892209350983,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06144890669212977,0.050318863204955114,0.2226634996010147,-0.16034224971590913,0.037444436331649594,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03423397934302548,-0.045941081076732025,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009889591791299479,0.06634026227171337,0.8815632754211817,-0.1402703256803351,0.12049114209773615,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06182481323764023,0.04278434788854965,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029976694625224228,0.05362744426014278,0.5764574954290441,-0.13537250253736838,0.07541911328691993,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.029573701957922825,-0.048747611059765265,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028377764808429275,0.0433740951264503,0.5132863468247784,-0.11362232310090856,0.05686679348405,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04458413384264039,0.008369977523568372,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05498020276354842,0.037871375751650116,0.14727576368845482,-0.12941008282136274,0.019449677294265895,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03658263777565033,-0.05634346296220288,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014352690829561452,0.055702748917378385,0.7967845253363606,-0.12382716432107103,0.09512178266194814,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.021221661516585312,0.004255392946683575,0.9738068609884574,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007899433821294651,0.05427750284008244,0.8843523897238774,-0.11457282357923046,0.09877395593664115,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05063547482591824,0.049986242530623066,0.9880940960671373,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03985787275721828,0.1125738127791136,0.7234624502705965,-0.1813872026196695,0.26110294813410606,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08820721399283911,0.08668402577339533,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0048634825490170815,0.058890408222822675,0.9342185847666,-0.11087580427605767,0.12060276937409184,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06223783198723628,0.08932881281852711,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04299437296958941,0.07808728617092021,0.5821897164454274,-0.11047317945986188,0.1964619253990407,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07478879514708757,0.11508634558997867,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06972717674231939,0.04004858398323645,0.08236646970941336,-0.1484359968787971,0.008981643394158328,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.01680178649951338,-0.08514572514448544,0.643528579284767,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022454211657100823,0.07935880202598042,0.7773508196784887,-0.1784207166781969,0.13351229336399525,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07930426117860306,0.04283435157056887,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032517275055709456,0.06119993052327273,0.5954573724674965,-0.15279554321963496,0.08776099310821606,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06127286490303243,0.015852905080793706,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0015902395004879636,0.05286597453553823,0.9760163305229347,-0.10548950552195353,0.1023090265209776,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0384044589623472,0.048536127652934254,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012614119256791123,0.058422897895562154,0.8291568610138492,-0.12743459241605196,0.10220635390246971,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0575555769883814,0.04985724748480146,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0022525780921264548,0.07694142424339015,0.9766572277464451,-0.15346812979184024,0.14896297360758734,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07517835052606822,0.06911362456893073,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001713203550056981,0.03879996758856525,0.9648009325571019,-0.07454166906935572,0.07796807616946969,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.03436142343599586,0.00464167308029582,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05481209849572457,0.03430653051049569,0.11081916005024066,-0.12223586909863657,0.012611672107187437,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0495689673099714,-0.05804667362949306,0.70150119017449,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061484828029092074,0.07843376373922142,0.43351322440163564,-0.09266366834125256,0.21563332439943672,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08472873300450384,0.13500255339947204,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012164070545007722,0.04775955654595306,0.7990776710367343,-0.10602752268470986,0.08169938159469442,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.056260166539393724,0.051223151189511235,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026785744631074103,0.05723328041139398,0.6400076388543656,-0.08569673354110316,0.13926822280325135,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.02030757987624529,0.012978261482339817,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04959092331191143,0.04311067937429733,0.2506341268009483,-0.13431778182589163,0.035135935202068765,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06839104878880023,0.007433325078515384,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06660281158516836,0.04802074732805144,0.1661516850135521,-0.16097959069538442,0.02777396752504771,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.018780363615590927,-0.05334236631385044,0.7840604855201315,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008494236686987996,0.04615072640288306,0.8540551261989177,-0.0991958011950564,0.08220732782108041,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.004548273325369996,-0.027159798499267165,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11858064128089611,0.06277909030795188,0.05956411934619191,-0.24196248492981498,0.004801202368022756,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.10553839853584206,-0.20850796200668506,0.5680556875544357,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018761644839136882,0.04749589026660229,0.6930210773192653,-0.07458361515259417,0.11210690483086792,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.024142124228622656,0.037307181609830604,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08246564747492552,0.058883915823618946,0.16207014306586653,-0.19819217457093233,0.03326087962108129,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.10048655044227874,-0.14457188146622577,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005384614528270153,0.04201071339388291,0.8980706950490946,-0.08794967315077548,0.07718044409423516,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.015343601901911013,-0.001216702868353025,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0812641292987474,0.057483420056001565,0.1581532505316191,-0.19423821527170637,0.03170995667421157,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.09556528026069751,-0.14876126423154026,0.780274991675152,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019853929152304987,0.04672414901143366,0.6711028050158699,-0.11168246027116518,0.07197460196655522,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.019607250411634223,-0.0421626514797967,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05905661031087564,0.06441101638102713,0.359708963671556,-0.18564573279430893,0.06753251217255765,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0031255294487447373,-0.08417547710721056,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01720516840339128,0.05118664671273675,0.7369349174033835,-0.11780399534789993,0.08339365854111738,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04117622892762905,0.009749778418673891,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02005882941112982,0.04935360448049379,0.6846222937901416,-0.07693745839190583,0.11705511721416548,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03890676622043462,0.03650777423886315,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04314185809200311,0.07508707583888113,0.5658821060972589,-0.1044292807340381,0.1907129969180443,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03666990361550165,0.08926209015934038,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0876687606960453,0.05880274975922264,0.13670058711080318,-0.027898248021822877,0.20323576941391347,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07154147656788375,0.15228885391487762,0.7473242853882033,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016999209965769153,0.0482047632134914,0.7245216738102475,-0.11173764164366179,0.0777392217121235,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.022628705744997552,-0.03675611741885334,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02342412290466098,0.0419157811687294,0.576554793421401,-0.10580260805336031,0.058954362244038355,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06084516427721742,0.03457737514674684,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03390289164952924,0.05328944139192702,0.5249728047649854,-0.07082862793294155,0.13863441123200004,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03189051054002253,0.04804223012811237,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04076864756229904,0.052624623354123386,0.43892628780057574,-0.14419357804332056,0.0626562829187225,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06233213044496836,0.014927684050102197,0.9304126176629784,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022725350669835456,0.05541715118815752,0.6819470205704394,-0.08618782806253755,0.13163852940220847,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.023641047045715763,0.01942866439872398,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022292669945162394,0.06277467608279982,0.7226671897057133,-0.14566583816990944,0.10108049827958465,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0662839946639342,0.037982861033187126,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006500694118365836,0.05133602165976814,0.8992904938259672,-0.09439170440020175,0.10739309263693342,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.025335954331211427,-0.00022723435096527744,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04143360561434801,0.0747448236777568,0.5796299332712452,-0.10546489360469657,0.18833210483339258,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.11676558730453884,0.1501385220316009,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031535437169219804,0.060523342667573976,0.6025951737646902,-0.0874131102769143,0.1504839846153539,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.044823330741213814,0.10883129954032278,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06620764536898814,0.06768954648754985,0.3285550425396536,-0.06682488186938827,0.19924017260736454,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06263946962060897,0.09539912910049449,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027714341276383656,0.0775356379219698,0.7209326315351576,-0.12466903841868542,0.1800977209714527,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.011269420190656585,0.06725194167600104,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06741710385615553,0.06142953962171906,0.2730319633957458,-0.05331242274024979,0.18814663045256086,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07071514656561173,0.13666223290688928,0.8700354117066056,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04366472498087911,0.05059851878669426,0.38862393105534765,-0.14310768446282043,0.05577823450106222,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.026638502856291473,-0.027702005239151065,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05238902419819325,0.03747722825508466,0.16284578608908407,-0.12604427301243104,0.021266224616044542,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.11552998477312648,-0.14762830255663736,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010756202428581545,0.06947492037790333,0.8770326548949877,-0.14729758462350315,0.12578517976634004,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07104018012715144,-0.028832666289798487,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021085561707232848,0.05607529962534721,0.7070803414313914,-0.13129222155213535,0.08912109813766965,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0021049256715611705,-0.02836899457656147,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08713988634091095,0.07668282393859217,0.25641704183203906,-0.06356742953987594,0.23784720222169786,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.10566763263398143,0.19148187175901274,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053334284907991504,0.03727311384764814,0.1531624567732906,-0.1265883808577757,0.01991981104179271,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.06510733351434192,-0.1297708315975772,0.769983269073072,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04526719147525488,0.04939095033107222,0.3598992660850192,-0.14233687632616748,0.05180249337565771,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.01197847052167638,-0.0564774181013876,0.9133814160475374,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00785573160326895,0.055376029556416705,0.8872538252127812,-0.11668809261889669,0.10097662941235878,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05366585466065764,0.054080230590768275,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00262962166753194,0.05579337751994376,0.9624297171826804,-0.11228221057958984,0.10702296724452595,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012649952245862676,-0.017433822005008877,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011063054147402527,0.04800635894477003,0.8178486758319703,-0.1054115552872358,0.08328544699243075,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04467415572274906,0.05158011136397452,0.9781640470283297,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016119846836546523,0.053857453668531084,0.7648471175106106,-0.12196769992367391,0.08972800625058087,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.017633266657818034,-0.026095430718420163,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04304687509882372,0.04915960907134722,0.38169195297337366,-0.13966189724282355,0.053568147045176116,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.060056276350217826,0.0002806366295802527,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02613925149639239,0.09008515235318323,0.7718283874222716,-0.1509081081930746,0.2031866111858594,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09406728734995179,0.12752285045182382,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007958860873576942,0.05848395907938103,0.8918149395283927,-0.1069816178703141,0.12289933961746799,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03242420061581814,0.02990310535387733,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013896768765321917,0.04455459109485547,0.7552599944391766,-0.10146139522520337,0.07366785769455952,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.014033088943187794,-0.011057945308275892,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024557217558483536,0.08060613447751785,0.7607705247865941,-0.1338607116033399,0.18297514672030696,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04615440540849724,0.06534007340012028,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00970866723817018,0.05455721409963899,0.8588405491488977,-0.09751444840340234,0.11693178287974271,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0340842806346965,0.04207641871557844,0.9839047884462332,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05593039963143592,0.059844597672119026,0.35050673612014016,-0.17354498686094516,0.0616841875980733,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.024216889292096328,-0.0658563932012219,0.9088510667694087,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06430730526628334,0.08335821103299902,0.4408471836877923,-0.09951937189766305,0.22813398243022973,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.09058021253260634,0.1353437537106561,0.9320838159679753,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02929851419725136,0.07967223027413545,0.7132441615160361,-0.18588101022617062,0.12728398183166792,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.07847399197492491,-0.1250161656321329,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030007849025112273,0.06853851478853903,0.6617268124975656,-0.10469318397946298,0.16470888202968753,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0033344535093813078,0.021785557181809138,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.001991610674459082,0.0678143179531941,0.9765838520448933,-0.13526935544291518,0.13128613409399703,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03613480474075358,0.06573655518991141,0.9980529036429133,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01674967482888854,0.06345273392052597,0.791925098878529,-0.10795610311844084,0.14145545277621793,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07471183988579655,0.08245018225513227,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01741401309270056,0.04391736628348148,0.6919140834878057,-0.10372628034093222,0.0688982541555311,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.053538879005880585,-0.07744549616078669,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006403133585649085,0.1258633819313268,0.9594491077398961,-0.24096037605424953,0.2537666432255477,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.24236146427730543,0.3328699380613985,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0351318925814761,0.05635498540455333,0.5333402553000924,-0.07562444306967911,0.1458882282326313,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08111150759666855,0.10409595832503411,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03831576881675376,0.05751503825740842,0.5056383643384765,-0.07472045746380293,0.15135199509731045,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08830857799527388,0.11283735444766874,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01061242152979242,0.052158904591087164,0.8388663728371735,-0.11312205936602669,0.09189721630644186,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.05553769961783432,-0.06867872167045286,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016776880640153067,0.05282565697106092,0.7509458819746517,-0.08704314792482432,0.12059690920513044,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.050577124337031716,0.05015636387168637,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022950798621027637,0.047900727988177405,0.6320807454026256,-0.11709169971271007,0.07119010247065478,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.027643114344576274,-0.07092521273481837,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010387359716271966,0.05482921847455829,0.8498274190549077,-0.1181450546436145,0.09737033521107055,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.042239864695830166,-0.05972258557340355,0.9829418698029807,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0025879453004950025,0.061536751099202466,0.9664735776916229,-0.12352817819556344,0.11835228759457345,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05044962632593212,0.029509464744072917,0.9962315319978402,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04601629659985716,0.051500619317741164,0.3720694830541549,-0.14723218439489222,0.055199591195177894,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05694014305697548,-0.03534168098581867,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029407932899847607,0.06359597069640455,0.64400849926996,-0.1543952188683913,0.09557935306869608,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07629035047311827,0.03785057656305609,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03075357756759792,0.04319569200955982,0.47686469875027016,-0.11564751425395504,0.05414035911875921,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.04419756047688203,-0.06769233402096807,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06937882223938295,0.09589158745254392,0.46974654528154647,-0.1190801183454538,0.2578377628242197,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06672416748785717,0.1378204038553659,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0044539687668535225,0.06355655605887688,0.9441625433490495,-0.1293637918314102,0.12045585429770314,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.018777772877232448,-0.027176620040347505,0.9928545820017085,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13324352578779594,0.07468926091475112,0.07511263425900316,-0.013545774076746342,0.2800328256523382,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.038833727847479814,0.16311959882996185,0.6286648421036044,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08761693936098114,0.07309552135466015,0.2312995996851758,-0.05604013089883664,0.23127400962079891,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.028082959578011234,0.1114888323298842,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009215701476984611,0.04775229390941276,0.8470554707667308,-0.10306488011444742,0.0846334771604782,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06340555492199239,0.05287209082810887,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10640510427236724,0.07820448294667118,0.17433162421511453,-0.2601029874407784,0.04729277889604397,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.14250640289165842,-0.2275351726573591,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01071470436295347,0.08793633353081988,0.9030761087526642,-0.183538918628201,0.16210950990229406,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.08914156957598912,0.04362095461482431,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04722391107791397,0.04582295669572307,0.3033033287879261,-0.13728129882962462,0.04283347667379669,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.031403559375633,-0.045947815120426845,0.891229301693288,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03269584263895169,0.03938235904118187,0.4068641631743669,-0.1100953086380507,0.04470362336014732,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.06726036741262724,0.03668906851722206,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013429636256392982,0.05864548447812931,0.8189769764920903,-0.12868756626305208,0.10182829375026611,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.0012711360822240199,-0.08686567128211248,0.9783899072890752,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12316986638163094,0.04442292196013255,0.005794445046625551,-0.21047571909193935,-0.03586401367132251,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07965167092326864,-0.010065197592526881,0.1450987532495698,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045616452898906146,0.0668785374785682,0.4955453932742706,-0.08582217123808422,0.1770550770358965,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.02887922027404223,-0.06976022581035464,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02388411396591676,0.043368152374384863,0.582096840656875,-0.10911699276921284,0.06134876483737932,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.061035490313584614,0.036959128415064255,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014572682252964927,0.057232256552170443,0.7991319966668098,-0.12705314820040275,0.0979077836944729,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012359205807315945,-0.06246610363304087,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03677131817437012,0.05279206381309795,0.4864615446118504,-0.14052532498364623,0.06698268863490597,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.04474877331905178,-0.009616053327680082,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028903768595209815,0.036843954528255056,0.43317106246455483,-0.10131442339625973,0.043506886205840097,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.017228625572695312,-0.04147202304779157,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0060675124418139124,0.04777101532808397,0.8989881950339218,-0.08781846002525116,0.099953484908879,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.050540995844015425,0.023600992077936395,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.036403989042088,0.03164975166232395,0.2506762413290987,-0.0986063034109749,0.025798325326798897,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012251282475495687,-0.04391345377926557,0.8577585765822857,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0222004685656434,0.03562328456176817,0.5334731126242346,-0.0922120998986368,0.047811162767349986,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.049708302205610094,0.023391720217274856,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017136088404021508,0.0922586700807117,0.8527339875768386,-0.16418295829318322,0.19845513510122623,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.012843007291889898,-0.06759596657721764,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09198309595758258,0.05224893264619238,0.07901679461066434,-0.19466966893837728,0.010703477023212102,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.05028750215332757,-0.018075507777080776,0.6348535583192849,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046804494878753274,0.03586502230170638,0.19256421219411352,-0.11729122146857171,0.023682231711065156,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.026556704994668758,-0.05034635732319868,0.8135043727497994,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06202724243775334,0.04896183921109661,0.20587502122175513,-0.15825358086785712,0.03419909599235046,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.0617677449022952,-0.005031055269849648,0.8199879169384305,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007084425701699032,0.041274934999275134,0.8637990132362954,-0.08820343446272284,0.07403458305932477,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.016130888607413654,-0.017442762856897668,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01297206603551739,0.05459549038942026,0.8122986764966844,-0.12027040734821844,0.09432627527718367,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.023038957813054223,-0.00465386917142576,0.9762342004588465,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05225525880781558,0.04663041233993434,0.2630541677561005,-0.14389956611441015,0.039389048498779,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.03227254954076276,-0.053784863630957476,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.058910147583687116,0.04582163780094205,0.19924023855710812,-0.031144648100045767,0.14896494326742,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,0.07186710482567447,0.16096925089483557,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:999,TP53,CDH1,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10105587762129234,0.059467680272250925,0.08995693730445949,-0.21792969649192662,0.015817941249341938,438,12,450,5,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Lymphoid,False,443,-0.05308663705551641,-0.17731498614838506,0.6623259037556665,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1661835882093765,0.33266487854726645,0.6185451949998781,-0.49423969575884663,0.8266068721775996,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08434922307381229,0.055055689389989435,0.9572656024379023,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022473349757694314,0.2192995566442132,0.9185933866954885,-0.4128913151393501,0.4578380146547388,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05739276899590818,-0.06562842502423405,0.9901822239590808,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00910639823734408,0.18793445360829894,0.9614552060837088,-0.38220346085717066,0.36399066438248245,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.01391692396334485,-0.030588841597428536,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.18227757914416237,0.26154493758746605,0.4875507506775195,-0.7015099289524276,0.3369547706641028,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.21661111287752202,-0.4643844192862593,0.940275458344982,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08088256797723009,0.21298917834757858,0.7049788623285669,-0.503719548028358,0.3419544120738979,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1013172538326202,-0.21565270092955022,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10735865981974047,0.19165674596672327,0.5766880972317566,-0.2731280874400026,0.48784540707948354,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05239594879093289,0.15636174849788956,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11494385174848043,0.28931808512296864,0.6920431313025894,-0.6893128705722108,0.45942516707524994,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10381091141068985,-0.2740920493411368,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09532088512685731,0.17891487225219094,0.5954352752943447,-0.25987004455452306,0.4505118148082377,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.029043735010355724,0.09000519612095313,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021061639666669976,0.1684852659181508,0.9007830836284667,-0.3555471829071914,0.31342390357385147,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06519108891172268,-0.12612995478930086,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.17731703941121962,0.26493819771744803,0.5049421029311056,-0.7032858622976992,0.34865178347526,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.19110538834972238,-0.42676956101420194,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015363887994521905,0.16253503500599936,0.9248899256130432,-0.3380367293455833,0.30730895335653946,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08219657432955532,-0.1308865074269204,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16230792979497793,0.27059777415256275,0.5500591989608987,-0.6995124324787059,0.37489657288875006,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.25131446918266337,-0.46427137568346327,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04897570699344935,0.18862757756614842,0.7957015142685215,-0.4234487946461528,0.32549738065925415,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.070170936418161,-0.16575190193049108,0.9735235918682278,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030798106859872273,0.1577779663667749,0.845654008858718,-0.3440269729211512,0.28243075920140664,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07468487605315555,-0.1380314435364199,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16388416604127332,0.2946732076270592,0.5794120686127262,-0.4211161151076175,0.7488844471901641,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.07087914102555312,0.3195573430448429,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0581757729384869,0.20434039409744403,0.7764934474138658,-0.4638427453779008,0.347491199500927,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.3334194514230534,0.2693210268989368,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006634229700445823,0.14269005409145455,0.963014123711216,-0.28990980277628636,0.27664134337539475,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06945775963445103,-0.12237842254346162,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09943564904705704,0.16505601113825685,0.5483193930456807,-0.4271132607945053,0.2282419627003912,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08180063908793726,-0.2283850162429996,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010983293044592989,0.20174933492393268,0.956698700909498,-0.4115063626596418,0.3895397765704558,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10098592534628875,-0.15789140553956252,0.995747388821315,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06272371610740728,0.12892691903794995,0.6277289498616403,-0.3186760115068454,0.1932285792920308,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05841131501799184,-0.1637381793856387,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056917395160863575,0.2748471370287919,0.8363847945680511,-0.6025579497589002,0.48872315943717304,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14314508563806957,-0.22227701460625707,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16616261343217012,0.24727729890562622,0.5032345386723371,-0.6570701192296062,0.32474489236526594,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0397135446631933,-0.2647574680306132,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011857719801939837,0.17502648389624229,0.9461285075028283,-0.3593292225976397,0.33561378299376005,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.008199030857544944,-0.02643999659404812,0.993077588787628,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21356215011825191,0.2876161075097089,0.4596013768922169,-0.7845523161773083,0.35742801594080437,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16106249707734757,-0.4354741475076511,0.9366557334939974,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1412339322202922,0.15389258584877405,0.3610772363789586,-0.44674934270919486,0.16428147826861048,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.031070452944668658,-0.22211120277371682,0.9134053709502656,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03204379999587127,0.1899616061675494,0.8664025272953827,-0.3450776692764735,0.409165269268216,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.026080725947442193,-0.015763818235181293,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06730525178648347,0.12347165418832683,0.5869574816137366,-0.3124274771687988,0.1778169735958319,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.013622477758171029,-0.10089862286006693,0.9531324349182967,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08956152316817659,0.2111646404794104,0.6724289769537273,-0.32965329124922993,0.5087763375855832,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.009548288858952805,0.06915794444280456,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044348193289080136,0.13871603438753785,0.7498940791796923,-0.3197343397597548,0.23103795318159454,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04317689396555404,-0.12722534446241435,0.9644346245002389,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007216002025165128,0.19417499851080813,0.9704335261567933,-0.3927021126751422,0.3782701086248119,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08543738426054731,-0.12072902574350781,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010115932762004474,0.1142309676624212,0.9296205324208726,-0.23689307594565187,0.2166612104216429,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0992152996022167,-0.15090826729931703,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09542355470352219,0.3106177580326411,0.7593591991825208,-0.7120777705455973,0.521230661138553,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0670655894269189,-0.22906097288560218,0.9672325614747834,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13890682250240768,0.2781385345192902,0.6186410355891205,-0.6910816272714038,0.41326798226658834,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14563089464176407,-0.3453761508787776,0.9572656024379023,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047360090831920054,0.12827948652681334,0.7128043032038511,-0.3020270701889197,0.2073068885250796,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04875027770596413,-0.13953864620714646,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09126101447646517,0.23931317040847291,0.7037984083851339,-0.5663577261828515,0.38383569722992117,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1363390513433623,-0.2733258721514229,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11432852978477244,0.1260331186624179,0.36663285875891494,-0.3645359050847302,0.13587884551518536,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0871495531931126,-0.0736038827983718,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05425935049164213,0.18897944851376244,0.7746474956669717,-0.42943099029620213,0.3209122893129178,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07217077904298393,-0.1641350587583461,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007672450113436619,0.08750948918856895,0.9303190328537381,-0.18140075134161962,0.16605585111474638,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05386833859995228,0.006175815917550115,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0004348772967590984,0.10287172050219515,0.9966359175811392,-0.2046610636564588,0.20379130906294063,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06333520624167925,-0.07131229757775845,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020624618313437756,0.11794416915068637,0.8615557869970774,-0.2547733984778954,0.21352416185101986,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04723876830601545,-0.10281362385081275,0.9841643751662926,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006985221086166324,0.1550263401689641,0.9641554292176395,-0.3007809763046265,0.3147514184769592,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0455598490668431,-0.05843724594924578,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07361355360838043,0.12307535127676658,0.5511846504190936,-0.3179490182378272,0.17072191102106635,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08879654835459781,-0.19870999276722084,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02037763473494771,0.1490449709678419,0.891540354073524,-0.31626931291685373,0.27551404344695835,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.033480192082321954,-0.08103697230104585,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024368949789245968,0.11815806826912002,0.8370446012181808,-0.25894237339322373,0.21020447381473178,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07600057991908465,-0.12485025301649148,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023983894354010785,0.09000697513437499,0.7904570363617762,-0.20267033206235535,0.15470254335433375,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.057579131334553196,-0.08893455177946719,0.972929334907502,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0673595231495532,0.08866935424329697,0.4493323987609038,-0.24339044764157025,0.10867140134246388,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.007535722366665205,-0.09964026125801165,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030131480819135654,0.13600484685426112,0.8251419850564992,-0.30013523951867105,0.23987227788039975,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07158862685568998,-0.14656171518141797,0.9805354906255225,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012642504676388201,0.09012771955520067,0.8887411136357863,-0.19156865036734508,0.1662836410145687,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.033234976409543315,-0.04989485510268864,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0692636353658855,0.10791334788863398,0.5225196003884557,-0.1449714468220613,0.2834987175538323,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.029427368493726326,0.024879288618756136,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037225569477417994,0.12687353554169578,0.769851159884277,-0.2891013832303283,0.21465024427549229,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.038583255005381165,-0.09942619258120794,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2317618645762762,0.24553483278026264,0.3476119586655181,-0.7192101377497535,0.25568640859720104,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.40785526464893923,0.02485245206014426,0.9086350165348037,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08416405630240453,0.2417642344964133,0.7285169014429208,-0.3957986328442308,0.5641267454490398,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15333448109686662,-0.015701641566423584,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08045294982593104,0.3728657844926762,0.8296302564615552,-0.8206851226642575,0.6597792230123953,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11630120115151503,-0.21318981697431266,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0017663480573190896,0.1399502900423671,0.989956431797713,-0.27607010569069224,0.27960280180533037,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.035771860427621635,-0.06393676553136884,0.9991191172759399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00846504835459879,0.16627321100982287,0.9595037493953444,-0.3385591073685447,0.3216290106593472,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08612740848115602,-0.10981008510272612,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1630017753887338,0.1443119238106719,0.26152667643797706,-0.44949716695221176,0.12349361617474416,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14479695351114905,-0.377088897245035,0.8669652730965864,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002796611830388311,0.20240995944690834,0.9890052957378149,-0.39903796328184066,0.4046311869426173,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10595331287656246,-0.09520093133646271,0.999046747647263,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1821172089630022,0.22165257170256691,0.4133427071101412,-0.6221531993659156,0.2579187814399112,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.12244615578042635,-0.3838157994895478,0.9263451842579509,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12164673949397266,0.20728842600950872,0.5586980155762145,-0.5331662952451901,0.2898728162572448,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.12492816497623291,-0.26517626488159884,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05851797755811437,0.10623454118702906,0.5830381120575987,-0.2694202070570021,0.15238425194077332,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09508283931751867,-0.20637451729349868,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03294994672330768,0.13013620295296574,0.8006639774397,-0.22540308078194302,0.2913029742285584,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0017221584338173472,0.019664811840952076,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03760013853162802,0.17006023676850254,0.8254899150782479,-0.37521239423330793,0.3000121171700519,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07891315248823931,-0.1531969734672139,0.980597249022118,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0686500601720581,0.20118685131470432,0.7336874697453128,-0.46805645863742884,0.33075633829331264,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0882484010056847,-0.18474531688450574,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09070333895951213,0.29963287627816315,0.7627689685121335,-0.6855498072750801,0.5041431293560559,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.02239475362680273,-0.2008773917400802,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025044056931696593,0.26808261325136246,0.9257672946812365,-0.5572553339123297,0.5071672200489364,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.050090213825135656,0.0076040614467656085,0.9915432628301946,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027824003504529307,0.19817201897200418,0.8886386235020588,-0.365597196027084,0.4212452030361426,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.00393659939317909,-0.02747594001087339,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02341191661745771,0.27420906333270195,0.9321391275603198,-0.5677857347700189,0.5209619015351036,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.024488941216983133,-0.07728130955944068,0.9918526261485133,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07234088685087701,0.1947545794628663,0.7111322119941663,-0.3142958374657884,0.45897761116754243,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.012790304318680362,0.04664475904207902,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05317519627848666,0.16467110881925445,0.747467328534629,-0.3800886803108824,0.27373828775390907,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.028463680743658,-0.07307421871796134,0.9633699714089764,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030023903513291504,0.1943926053228786,0.8775827241811518,-0.35589421127871895,0.4159420183053019,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05165494267985692,0.06267707929331928,0.9858833377512005,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03838404047521401,0.12743915410180368,0.7639240356688938,-0.21461466809175386,0.29138274904218187,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10315661280534777,-0.0754491470377486,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.000525799131734046,0.1195126141304272,0.9964989210421349,-0.2377883362661711,0.23673673800270303,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08319732127316842,-0.13101966425046102,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05093832658138527,0.13778789826089716,0.7124389015998093,-0.32448188987525334,0.2226052367124828,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.018004794867319547,-0.10880782150339172,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10220518771690561,0.2320565873572769,0.6606246585900295,-0.5628957606388573,0.3584853852050461,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16712849329608087,-0.32441104755761385,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027416903107001102,0.1629084400540717,0.866707893378726,-0.3508310472044635,0.29599724099046126,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.07895842422353423,0.028424838853896572,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1489901542009105,0.17065572027137546,0.3848398692298839,-0.487784594124242,0.18980428572242103,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.24698603570382643,-0.4236340345812641,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01658084049848026,0.15482223008063506,0.9149386696544779,-0.290780147134631,0.3239418281315915,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04788662128058559,-0.053678153393111175,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025276232505234333,0.11762852882812941,0.8303200701044442,-0.25879838740258776,0.20824592239211911,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15943105181208242,-0.21182683075416012,0.9817239773275311,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09946690751403647,0.12313214108773679,0.42122026220855924,-0.34391511417270093,0.144981299144628,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08406220821697327,-0.22810509795614306,0.9282753503874777,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039168683300724275,0.11097300511151084,0.7249027309300885,-0.25947795306078153,0.18114058645933295,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0937813328119753,-0.16588010610320628,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06629815873794902,0.13206730167114994,0.6168270659178378,-0.3284849019113502,0.19588858443545215,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.13377218663648027,-0.23701037596792948,0.9565097185496769,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02871701805049123,0.05878114317508236,0.6262923063981252,-0.14541234152624077,0.08797830542525832,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.01599482242116254,-0.07266347777275536,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055659171566458804,0.14408456122426117,0.7001418922791062,-0.34170319132710447,0.23038484819418684,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.021117766470368678,-0.10575551465439807,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044175023083444905,0.06226034546257574,0.4797390402260011,-0.16777743639185216,0.07942739022496237,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.03672611016949794,-0.1251839663075272,0.9384348204322319,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02060078892106841,0.12838141060563324,0.8728551067466725,-0.27547011315782705,0.2342685353156902,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04251418892127201,-0.09590161090304831,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042961537548397655,0.1344345088641325,0.7499943231342876,-0.30984778117718165,0.22392470608038634,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.053817625699125696,-0.12646139729137837,0.9644346245002389,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06406107749216666,0.2546905506406934,0.8019514187233167,-0.569685748735911,0.4415635937515778,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16799059219895854,-0.27568499089588067,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06675016152676225,0.18769106733742183,0.7228998082119731,-0.4393640413080897,0.30586371825456515,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.051700065659367446,-0.16436615971814933,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06918684111245137,0.14027926418105674,0.6230038877659511,-0.3476763910994249,0.20930270887452213,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11747248558810454,-0.21820512722955954,0.9584620018167673,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014738003078337813,0.16117776762814798,0.9273359671871605,-0.33471632800548945,0.3052403218488138,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.004292821465518421,-0.018415979773644897,0.9916764739841218,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08204913099399383,0.19587187181188837,0.6762407554431635,-0.47090396106776844,0.3068056990797807,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1076069442709993,-0.23983685902910096,0.9619311554974709,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012328465616962232,0.15294867279439273,0.9359254592912175,-0.3159699717674289,0.2913130405335045,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.051940554269782044,-0.09381230152183263,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06364928590173344,0.16009653684592126,0.6918404400449754,-0.3814810963334444,0.2541825245299776,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10282323647033684,-0.20128871537041784,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05832650730769415,0.1718458454646596,0.735048714988753,-0.3994836444652946,0.28283062984990637,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.01722751133862348,-0.09605986562457053,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.113758357624018,0.17769802957107486,0.5235979564425528,-0.46653354915159984,0.23901683390356387,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.14590983035624344,-0.30319655438247295,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017127425115583572,0.12681992129325412,0.8928556163963552,-0.26889680112797265,0.2346419508968055,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.007179769237497498,-0.030811946238501912,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017374944856399746,0.13957613902112473,0.901195383400935,-0.2597187252012262,0.29446861491402565,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02800747171422419,0.03629831223431313,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03436417859045082,0.15085499591127421,0.8202943228290129,-0.3338492106076825,0.2651208534267809,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1311294888526834,-0.20953905150264346,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0617991410887247,0.1671256984864682,0.7123721268073546,-0.3935856017211598,0.2699873195437104,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0580380741081963,-0.16497228942765974,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024256353981424998,0.12625076363292975,0.8480517405259751,-0.27489580917750017,0.22638310121465016,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.004574853168344059,-0.07343882882942121,0.982606147466821,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025429490573521875,0.14066603338686648,0.8569260110066197,-0.25382789336741185,0.30468687451445564,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06059567511726386,-0.05512392815715471,0.9836246458712524,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007282539269120314,0.0610995761397104,0.9053754667267052,-0.12858053411446646,0.11401545557622585,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07148593300092652,-0.068092319589151,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0532234759473093,0.16477343106673478,0.7473975112581543,-0.38034009532419666,0.27389314342957805,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.03175539034749084,-0.07028657791787132,0.9633699714089764,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019979015975838236,0.18297613838749033,0.9132827445012971,-0.34327454637616317,0.38323257832783963,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.06805214671353495,0.09958563822314279,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03286904461083318,0.1870202493056635,0.8608634443070171,-0.4041511822214403,0.33841309299977396,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.022345931439917147,-0.06501947406146757,0.9841643751662926,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05460516614680709,0.19539841117949214,0.7805027738561887,-0.33330972573138073,0.44252005802499494,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0793840752243788,0.12715467434446498,0.971254274787651,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.058484607883112355,0.15472211315080017,0.7062755592442931,-0.3656468382808007,0.24867762251457595,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0696062106570772,-0.03864404117409072,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033836981544951766,0.2055743734025941,0.8696106925882215,-0.3742797495483209,0.44195371263822436,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.1156855060446495,0.14414657843175072,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04683302034252659,0.07960314615219585,0.557706094933974,-0.20486524612366203,0.11119920543860884,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.028124994811382368,-0.09565908558726335,0.949991921327294,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035932842190317976,0.0909257888318243,0.6935896106687951,-0.21644335571356177,0.14457767133292582,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.00842641855771341,-0.06577562669467199,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012548073463019744,0.10173295721851884,0.9020958742191081,-0.21451352887104166,0.18941738194500216,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.027840457961494935,-0.07189644031673317,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032854635004197684,0.13040354107053423,0.8016271490419313,-0.29173839577562743,0.22602912576723208,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06079026978362665,-0.12978679772497753,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03055792641669572,0.26679715062630904,0.9090544954221556,-0.49910138459757647,0.560217237430968,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0726753489694203,-0.06802783812791313,0.9888301126476031,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15102905011796292,0.1545548308122958,0.33095818582950154,-0.457859183085266,0.1558010828493402,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08405745462622269,-0.300119911593503,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03717418511858572,0.09238965124935064,0.6883207470633003,-0.22059083297522306,0.1462424627380516,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02372215440574426,-0.04045146353318124,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08092031432184736,0.14591514970722905,0.580491389351755,-0.3705985117053174,0.20875788306162263,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06665380740399415,-0.18283035532898712,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10966611346388723,0.15327711359620183,0.4760697099489428,-0.41395965704573884,0.1946274301179644,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.010706935760274714,-0.15410218099219564,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09074295274880399,0.11149664654972428,0.4177589344314515,-0.31209178219955347,0.13060587670194546,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10044147343391054,-0.21295096544060255,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13026132639688603,0.18000000499330968,0.4710441084075776,-0.4876065169415131,0.227083864147741,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.03178626623789903,-0.22473921815184372,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07676787108963196,0.13559258223991816,0.572616155411569,-0.3459531810498317,0.19241743887056778,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09129899843571412,-0.2007312419797968,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.060931625238843226,0.25050588164920046,0.8083483252925571,-0.43638542769018607,0.5582486781678725,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.013638208754726128,0.050802293207498336,0.974516576191754,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.15075623549739792,0.20651087998019482,0.4671767690899915,-0.5607321672136454,0.2592196962188495,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.16527966803362823,-0.3684338124818677,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03137784904866527,0.28049759078662584,0.911166508358944,-0.5254802745423935,0.588235972639724,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.022029301891673007,-0.001784205292833696,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.2699052875386552,0.2539175437100467,0.2904927138584824,-0.7739953459976139,0.23418477092030338,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1932054560276884,-0.5004716004711136,0.8780447660402404,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041247998972591376,0.36814428521975884,0.9110256940410164,-0.7721068106412906,0.6896108126961079,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.008239477617491683,-0.06247829414835264,0.9891749114349121,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.10519182035450696,0.13981417447942826,0.4536894992070284,-0.3827580505446007,0.17237440983558677,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1484185503550664,-0.30370976648736925,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057444234060127816,0.15349209805132932,0.7090532527938054,-0.3621645757472602,0.24727610762700453,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.012323125824442806,-0.08702690307179287,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04059716005651242,0.10592878403176688,0.7023910031203939,-0.2508923848560857,0.1696980647430609,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0421210138432964,-0.013274678632827353,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04308727097990483,0.08637847940097601,0.6190596115535348,-0.21457023389229024,0.12839569193248057,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09664220094539347,-0.16254512358607592,0.9575399837318704,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.16584688713033038,0.1340670916412563,0.2191199495553586,-0.43200371534869286,0.10030994108803207,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.06472461940948743,-0.17781786231016716,0.8337844604918982,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1550310232552842,0.2329854005911623,0.507400059321228,-0.6175655235818795,0.3075034770713111,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1827947652081743,-0.39067318387397537,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039631340714899106,0.11936561199466694,0.7406082896344108,-0.1973393602820019,0.27660204171180014,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.046769790963583545,0.07162001894458495,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015983093287210516,0.10828232666659737,0.8829667473120886,-0.23095069096438273,0.1989845043899617,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.049258927457485925,-0.07773309987877115,0.9870713197539774,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09934341462816682,0.13401970790998533,0.46036441544456475,-0.36540617424647354,0.1667193449901399,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.031129034911560743,-0.1617659046510414,0.9366557334939974,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026207396928903802,0.1367375952261246,0.848416058557399,-0.2976658450690009,0.2452510512111933,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0808496314012465,-0.13891902091926567,0.9827413793708789,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06398261783116733,0.12124367702320661,0.59892464892697,-0.30468174931063224,0.17671651364829755,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.014794932748070071,-0.10158029663078874,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03336497942834662,0.09717965031931625,0.7321066071504642,-0.22629097774544127,0.15956101888874802,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06470343336620997,-0.11554256639664165,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027719300161517742,0.12357215758127253,0.8229926119899245,-0.27304105000553464,0.21760244968249917,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05338369457942127,-0.10196565053335896,0.9798720835700006,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0808202750129205,0.24032259020600233,0.7373870088403267,-0.5579209383853141,0.39628038835947316,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15323538423799257,-0.27814042435734887,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.054513493799725456,0.1893310331627163,0.7740299151934268,-0.43038311738143953,0.3213561297819886,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09384597256972306,-0.18602282107741336,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006337117323022862,0.13083742237760376,0.9614712068617517,-0.26608224139471637,0.2534080067486706,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.007144781869107783,-0.026521061464965752,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13340307026223058,0.26266834578027426,0.6127171666510027,-0.6548656673126187,0.3880595267881575,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.054049986359139705,-0.2631825798122541,0.9552369178668337,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0268940789658147,0.2154884781263303,0.9009414984037557,-0.4546927964107798,0.4009046384791504,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.030205860926062374,-0.09566405612149083,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04204030794342718,0.15396347471432584,0.7854045759369328,-0.34769645062380417,0.26361583473694983,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.032222255599183326,-0.08250079075160908,0.9722536916492144,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039876251369302305,0.19207517058537096,0.8359798212018066,-0.34144117378450406,0.42119367652310863,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0675063619475292,-0.061368475496056916,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.19295336246393802,0.22596490845358042,0.39530374882381225,-0.6415504237292705,0.2556436988013945,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.09003781189101535,-0.17576282137663102,0.920957044807631,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12167784465731533,0.264414536776475,0.6464397541557942,-0.6466070691352296,0.4032513798205989,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.005471745087508851,-0.18618729904853684,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04462022767168624,0.28335567678414497,0.8752080782067178,-0.6071523693574354,0.5179119140140629,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.008780354582267728,-0.10420306529046655,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14123396221443194,0.21396915004699438,0.5108080748501618,-0.5660164320652357,0.28354850763637185,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11840122049295326,-0.3202245913875015,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021649674823581287,0.23837735266485402,0.9278260273674255,-0.4948885534153465,0.45158920376818396,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.03585218956642465,-0.0392093962950814,0.9916764739841218,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3263369139189731,0.43050084190946825,0.45030334113634285,-0.5283153144933493,1.1809891423312955,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.15512157486455758,0.3200856866921219,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07608905031050756,0.14285798810264358,0.5955401579529451,-0.3596980145505845,0.20751991392956937,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.1132532529050301,-0.21875268370723702,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09032484342930376,0.13413316130666478,0.5023298658977899,-0.35661283651721987,0.17596314965861237,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10992482046050059,-0.22823017005914142,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0013204482877444204,0.2034522298764657,0.9948352052777079,-0.40258329524069125,0.4052241918161801,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.08674664817256694,0.0604550996377784,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04856954151644334,0.12380988843434722,0.6957217301492363,-0.29436324677509185,0.1972241637422052,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.036473529665373705,-0.12795796611154792,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02580574196524736,0.20014589911532762,0.8976819347439132,-0.4231455890322004,0.37153410510170565,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02022724044235015,-0.0300789192181241,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0033378863670772904,0.21054246659456033,0.9873843201389592,-0.42131752945522805,0.4146417567210735,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.055808470425374165,0.0273408009074948,0.9990191441902606,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026601817205674956,0.10251485100531685,0.79581690446371,-0.2301195280385752,0.1769158936272253,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10695078936779247,-0.17418714505329255,0.9735235918682278,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021905606515010712,0.07221836017033982,0.7623057554274901,-0.16527717851496587,0.12146596548494444,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08678884888310823,-0.16451406478312416,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0012666857273385124,0.17796237812554638,0.9943358574702461,-0.35456667548796117,0.35203330403328414,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09944685873515605,-0.1273518514087447,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0367977216403718,0.15909227671005208,0.8175807617451938,-0.35263582362956425,0.2790403803488206,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.023794323412364572,-0.0258689318510568,0.9781640470283297,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06870956319987515,0.3511616610737646,0.8452913599359494,-0.7658536032405201,0.6284344768407697,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.09618370079523603,-0.21686334318323236,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0485602001070044,0.24139772736259618,0.8410014957202033,-0.5277952805984361,0.43067488038442725,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02207327507298136,-0.057634002537958584,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.21289876419533205,0.25809779001775207,0.41150822435057877,-0.7252876608315783,0.29949013244091416,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0454191101285034,-0.2458525750280854,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05530487528553983,0.3087805715442619,0.8582348358944816,-0.6683118148079267,0.557702064236847,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08097080109208636,-0.19389228405000206,0.9839047884462332,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09092455291304066,0.1343011783245469,0.5000386889392028,-0.3575461019543139,0.1756969961282326,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.06814583659713261,-0.1911493708095331,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1557938324889136,0.18650170636490493,0.40561775142695056,-0.5260465322060172,0.21445886722818996,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0343030254416068,-0.21800937421988237,0.9237532919369174,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08313656458972772,0.19932122891328807,0.6775474796516946,-0.4788392343105176,0.31256610513106214,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.18835358072313102,-0.31154127546625693,0.9619695749374265,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04337930823587134,0.07752182910011389,0.5770860490683776,-0.1972795972507403,0.1105209807789976,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08092569570017696,-0.13537090070617777,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07420523739368035,0.1752266157225934,0.6729011930120278,-0.27366357731111723,0.4220740520984779,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.0975425633481535,-0.0026832162502144997,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07544762192230717,0.11645513216733516,0.5186326677227232,-0.30664028992130454,0.15574504607669018,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05302780414000553,-0.0646698970969171,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11420209050399932,0.2026509899803748,0.5743945409347904,-0.28811099071667035,0.516515171724669,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.05466325054455342,0.11571084201743542,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08634500642248437,0.15431954820196228,0.5771231075080967,-0.39270804435151463,0.22001803150654586,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.02890620813128299,-0.09032349426074945,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.049293178426304096,0.1439909703928819,0.7328548742542238,-0.23656504004242657,0.33515139689503476,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07662600011054915,-0.017607010662954427,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06941291231292551,0.09657445729563076,0.4740589953746689,-0.26113745057243176,0.12231162594658077,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.009366185699864873,-0.10067071559846294,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008464540124862138,0.142287997889366,0.9526877594954868,-0.27401285047231505,0.29094193072203933,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.07699417447489518,-0.0810228648583377,0.9940904623189993,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03701165427689048,0.08987822647888967,0.6814152930739319,-0.21544249358773235,0.14141918503395137,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.003582490467539026,-0.062264311319256374,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.014022575003154533,0.0951337227744025,0.8831298082974989,-0.20288689360860207,0.174841743602293,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.13690306906261948,-0.17690947875923005,0.9870713197539774,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024905652101027628,0.0681418893345825,0.715553028225149,-0.16018440628351963,0.11037310208146436,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.0014065878983552113,-0.039461623226183004,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06721420300995774,0.09130363043052847,0.4634464024890894,-0.11404642092628102,0.2484748269461965,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.10607842204564698,-0.03893238008621318,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1639749406296713,0.10680035657172796,0.12802402472944138,-0.37600045568883345,0.04805057442949082,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.09414074060694987,-0.14180278163644505,0.7288842902994255,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050096193986124624,0.2097163550259333,0.8117163318394751,-0.3662434102813988,0.46643579825364806,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05981182442806859,0.11704698578701231,0.9759776192277725,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0324856901492011,0.1152788080019843,0.7787090128341778,-0.2613430594184835,0.19637167912008133,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.04433152920322866,-0.09944752099459869,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04111832960872524,0.18395068932068126,0.8236037190874603,-0.32406996096136426,0.40630662017881475,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08711803784318281,-0.04038796499190437,0.9798720835700006,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01103376125799137,0.09163632914485582,0.904414122879829,-0.19295487565071473,0.17088735313473197,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.005971650378444127,-0.020524814236057797,0.988603595072994,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021569601127664303,0.10661200498485583,0.840100233870049,-0.23322119100997596,0.19008198875464738,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.003764284664981196,-0.056024138435409654,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07157917011146103,0.08907251697467629,0.42363099825434236,-0.2484104738205264,0.10525213359760432,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.08267787889548074,-0.18235579496889304,0.9288749656602147,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06326877649044471,0.21689954216979784,0.7711549012335284,-0.36733125726283006,0.4938688102437195,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,-0.11496202275636126,-0.051933007162788994,0.9692333998776356,1.0 +ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06351947083767202,0.08360832184906547,0.44929918850583095,-0.22950297569024847,0.10246403401490443,94,5,99,2,log_other_mut_burden|lin_Skin,False,95,0.05568053062142412,-0.033693203231762746,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15886397539949304,0.21790754320452574,0.4666290294626495,-0.27021661825340665,0.5879445690523928,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13173987997730077,0.34275408384993405,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04345716322398747,0.17067055768061193,0.799212473258767,-0.29260933145414386,0.3795236579021188,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09177411946315468,0.14832010904621526,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12831019303884708,0.10818587900358727,0.23669450922565186,-0.08471805052292003,0.3413384366006142,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.03747162667052356,0.16784840263767942,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08738790710461895,0.21082629356359764,0.6788470155333423,-0.3277490352407077,0.5025248494499456,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.18125037647415895,0.32562817390897975,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0922036078472984,0.1641821721183017,0.5748750450514732,-0.23108664105254012,0.41549385674713696,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17642235547050292,0.22280772483327488,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17754941458176193,0.09069606725068959,0.05133888689990685,-0.0010397329328935,0.35613856209641737,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.052299980550482184,0.2166445879908191,0.5316325649082267,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05651185542363154,0.18055317011488436,0.7545360332803301,-0.2990144392585736,0.41203815010583666,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15979879573138672,0.2181115299147381,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1204129583132145,0.1276354927883505,0.34634225036096666,-0.13091341713677682,0.3717393337632058,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12822285357446817,0.19029788327950067,0.9075908470661285,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08488367763319196,0.13270155754274057,0.522955701894245,-0.1764182591963219,0.3461856144627058,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0996849502947963,0.14965255870577537,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0004158011017592209,0.21289891803062425,0.9984431886975931,-0.4196339373500275,0.4188023351465091,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17341555886574475,0.21086149326129794,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12346041322684777,0.13714080284130423,0.368819407942903,-0.1465828180987943,0.3935036445524898,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12473967743250411,0.29421480375620856,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012185244218154189,0.20830285458126882,0.9953370516874218,-0.4089495275369667,0.4113865763805975,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17209458114253262,0.18611490198868777,0.999543673283893,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14632705961592996,0.17879777713414546,0.4138787024911671,-0.20574270000928258,0.4983968192411425,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11701410751361552,0.28437126176208094,0.9264385999319894,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08870003378658024,0.14015539120134196,0.5273731319246251,-0.18727920757396938,0.3646792751471299,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1213231346222374,0.17567186585794586,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22985401050715276,0.23906919468037163,0.3372138635492521,-0.24089587941884233,0.7006039004331479,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.02867777412605974,0.14540975299575645,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10763181062439002,0.11224843488870785,0.3385109422056246,-0.11339599029689222,0.32865961154567225,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.055972869352093016,-0.02790734921247392,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03469831813840367,0.10579579023148446,0.7431939113044741,-0.17362361423222472,0.2430202505090321,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06581373967789837,0.05643647477616591,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11462273887600553,0.13043285102691007,0.3803249002665059,-0.1422118999227877,0.3714573776747988,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14032427838410272,0.3032910536043016,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08384783618275793,0.13973954745818054,0.5490072364558172,-0.19131256945710684,0.3590082418226227,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09965627796817267,0.19317769377955532,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08920323377708217,0.1113582532190715,0.42383284525337583,-0.1300717151150806,0.3084781826692449,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09360006046036633,0.2282101624967622,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.22119180865469293,0.22732594305146395,0.3314461878421877,-0.22643450644572702,0.6688181237551128,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0700495856143615,0.27601072814378447,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1046488351742159,0.16496371836437593,0.5263918440777062,-0.22018035231536193,0.42947802266379376,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12554874318031223,0.28531070428387356,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08272303668041485,0.09995112484351903,0.4086333973884717,-0.11409019591098225,0.27953626927181197,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.01155068217690298,0.044066593450057714,0.9253726913029282,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02003586043719618,0.1859198582461611,0.9142640192297391,-0.3861296724042751,0.3460579515298827,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1813910814281881,0.16164721292326611,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08541506057108006,0.1201983466080143,0.477955733412029,-0.15126686957328503,0.3220969907154452,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10343216386097034,0.17730923495633283,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.106315323483189,0.13338229754738687,0.4261335816237537,-0.15632705489791798,0.368957701864296,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14964512438517974,0.2752374478026129,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08454664681922873,0.0983562136609696,0.3908003990904102,-0.10912605457729531,0.2782193482157528,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.024405453325026055,0.09256518251202943,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12059226847653544,0.11240680134763259,0.28434278686239106,-0.10074737100348065,0.34193190795655154,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16023700967727628,0.32748607443115096,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10597069290431221,0.13412272154790075,0.43018518785373216,-0.1581296504697604,0.37007103627838484,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07520306118595084,0.1718679465155452,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06332765042241621,0.1064778148373302,0.5525260239376788,-0.14633725300124956,0.272992553846082,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14705624299771286,0.22544433190436527,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09907879061626655,0.1297432493028674,0.4457639473740036,-0.15639795706602427,0.3545555382985574,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1326792318230554,0.18981440768323352,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12604471567817266,0.17576762520501774,0.47394750512289785,-0.22005838777034997,0.4721478191266953,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10539670612150868,0.2142470591476881,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03872798939055699,0.1627777278899871,0.8121302299200666,-0.28179677578909657,0.35925275457021055,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14293950995984842,0.1853159678151134,0.9761795525598862,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14411660916532204,0.15064860549582468,0.33963381442745766,-0.15252476510073143,0.4407579834313755,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06018009252096886,0.2027207530637895,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09430258300531696,0.1774380675681827,0.5955468122136618,-0.2550897796873294,0.4436949456979633,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09484093919163465,0.18113185107638144,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0416613665680325,0.07913927020514164,0.5990358369586961,-0.1974940859934799,0.11417135285741488,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17425544925006606,0.1798932417373612,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1278612967041619,0.13105919643387878,0.33016628424848216,-0.13020667553092113,0.38592926893924495,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10211972248984628,0.1930901207089904,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05531753244935366,0.07017207908028657,0.4312292918519217,-0.1934930031413762,0.08285793824266888,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20734495426342242,0.2223614047807665,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10442842216491448,0.08943294097601308,0.24400431994147226,-0.07167351006647711,0.2805303543963061,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06729790360266788,0.12578916068711105,0.8528284808184983,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04115899261157281,0.09900495690605755,0.6779516808440669,-0.15379114568611157,0.23610913090925717,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1305253711040649,0.13778033058166145,0.9620942694833536,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09912979320732077,0.10441072276024414,0.3432845221429641,-0.10646481011324668,0.3047243965278882,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06703865833115073,0.13216221676953205,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02515747818841582,0.09990774257648204,0.8013883363273537,-0.17157033060984175,0.2218852869866734,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1107427052521929,0.11008994605797806,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12046510290959872,0.11441874542980554,0.29338617516421117,-0.10483624504769085,0.3457664508668883,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09587549623742246,0.18142489897705943,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08203349551369808,0.11732241906536624,0.4850408477796285,-0.14898546087971276,0.31305245190710895,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14768135184336426,0.17141816176726116,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.041680874446291996,0.07990059737078369,0.6023500865632131,-0.11565097028429068,0.1990127191768747,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07543457473811375,0.11965741679780906,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07961052294359387,0.10716108627561469,0.45820724004748037,-0.13139980666428625,0.29062085255147396,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0878764456562469,0.13601400953053924,0.9364698948241243,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1113599759993763,0.12826937995623588,0.3860973478544799,-0.14121458332853576,0.36393453532728837,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10825070924153772,0.17148261702936807,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07004240467344403,0.08057400891832746,0.3854857044718646,-0.08861545118251579,0.22870026052940384,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.05384774926747732,0.0922797090639069,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04361789684535722,0.05532583192042919,0.4311886951183427,-0.06532390689237251,0.15255970058308693,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07930648102511971,0.07216415215257918,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11595180967395044,0.1357997855799275,0.3939744921906835,-0.151450831637466,0.3833544509853669,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1108001950098515,0.20965703499195928,0.9200851777021611,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032214079635908686,0.07274700333535174,0.6582602159532017,-0.11103166082156943,0.17545982009338681,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.061818432997738794,-0.1102088601175458,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043764206428743284,0.08187602411083536,0.5934382449615201,-0.11745744067340586,0.20498585353089244,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.2168736499536879,0.2573883086901889,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21871630320466226,0.18633517818154133,0.2415535573036272,-0.14819531305596315,0.5856279194652877,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06602599012309468,0.28441476778787095,0.8488057272581641,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042718144254699046,0.1277153230920685,0.7382864586564908,-0.208765424625162,0.2942017131345601,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12346688110707989,0.2573647557133608,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14339602361814058,0.12674040138918297,0.25891884182611535,-0.10616783208021488,0.392959879316496,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13512113875777948,0.2779259786904943,0.8664830381179188,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04674103952061811,0.1680203169912633,0.7810891965457836,-0.28410688019867647,0.37758895923991265,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.23187610600787215,0.23949577633975278,0.971527114099096,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17978591161468763,0.13690826165762846,0.19027384903179734,-0.08979942409305611,0.4493712473224314,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08408234533492667,0.2085964607368858,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03431427284271983,0.15434698408138825,0.8242394012127991,-0.26960955918367535,0.338238104869115,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.19849019355855585,0.33598466171704383,0.9798720835700006,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13339904389776922,0.15279142699258952,0.38342234985211443,-0.16746174887212686,0.4342598366676653,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11490382169342467,0.20263550341116007,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1109002768279353,0.15004683853472373,0.4605077843027131,-0.18455616128991176,0.40635671494578235,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11501825865352507,0.2100457649993802,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052637601439660495,0.060940860421899716,0.38851890621640306,-0.06736072529565808,0.17263592817497908,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10612281663743703,0.09498480792136274,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06353413840704261,0.12159274394422497,0.6017544258063352,-0.17589349217527256,0.3029617689893578,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.007420869885002095,0.06115004356977604,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07366588541512925,0.14610891815635452,0.6145569120501456,-0.21403641446197508,0.3613681852922336,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12567811373380933,0.13014171209392064,0.9557595790374268,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09041625257987755,0.16425914792946594,0.5824823750861327,-0.23302556898360333,0.41385807414335846,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11444032350159453,0.24919625712450816,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12335220796645562,0.12248551636225559,0.3148310443415757,-0.11783337607397353,0.36453779200688474,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07507928195262002,0.16290419013035412,0.9025176929330414,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1135019389259263,0.14727991861443468,0.44160875865957927,-0.17650617177503397,0.4035100496268866,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11232958808966867,0.20345410176615142,0.9325592780632456,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12470077406064513,0.1537172032047286,0.41796989327932765,-0.17798295976421724,0.42738450788550747,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08762801973821983,0.1857633904015973,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1466890591741532,0.09662037310861878,0.1301743007155422,-0.04356560774895937,0.33694372609726575,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17221777398276042,0.3002835531899394,0.7333906673033306,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07867812964927966,0.12593087594434638,0.5326662731128211,-0.16929169376667064,0.32664795306523,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11605221466143449,0.13372669528939984,0.9463401736865253,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10471648911991965,0.0938791065786309,0.26568797602430017,-0.08014036434180197,0.28957334258164125,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12329190477084269,0.1859538282115717,0.8693121373799397,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09233542941155867,0.11693256283531296,0.43045082616302566,-0.1379158631361195,0.3225867219592369,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14432629568415517,0.22685147667192657,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02156080647566685,0.11138456862691876,0.8466624768058408,-0.19776595994724894,0.24088757289858265,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16148805360817314,0.16923313700582218,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08367546880026612,0.13288241535339063,0.5294446123863847,-0.1779825941900005,0.3453335317905327,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10557198271044688,0.15440803341685036,0.9450734236122966,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1006586586519333,0.19746716947431026,0.6106581907705486,-0.28817290293136044,0.48949022023522704,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12615889113304363,0.280607242857321,0.9549530254352627,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12041537750089785,0.08034682449472676,0.13516129961320458,-0.037795130705165395,0.2786258857069611,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10313697023091467,0.15918398303875442,0.7471520865805139,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0247608930676513,0.15292855868047214,0.8715008137492848,-0.2763699249853534,0.32589171112065596,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16665767275447657,0.1814960909063799,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1280850192468134,0.11962501763369307,0.28528402762163935,-0.10746797183907555,0.3636380103327024,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09909479225991337,0.1736231038100915,0.8771632762317894,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07775005211747395,0.13186662145872174,0.555961309165633,-0.18190781647408655,0.3374079207090344,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14403926935482766,0.21105549441542593,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08286593462215168,0.12355103979084038,0.5030034258130767,-0.16041776597984647,0.32614963522414986,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09571705775165572,0.12240756241599549,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0945966576417295,0.12299194885925635,0.44251226637575547,-0.14758613995662706,0.33677945524008607,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06670962967599271,0.15949667236851062,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14073440749211802,0.14829094504899393,0.34347691829989724,-0.15126451002699948,0.4327333250112355,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12532416817576922,0.2696500737900365,0.9046447408422388,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005443580550821856,0.08297289732325466,0.9477411538684244,-0.16882507490848842,0.1579379138068447,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08288631905056383,-0.029548625198520678,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08211792693954036,0.12212652837538311,0.5019236475168714,-0.1583607757499439,0.3225966296290246,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09992285606667753,0.16298058383223105,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00979366078913784,0.08507173116103985,0.9084366326896773,-0.1773079577834272,0.1577206362051515,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0808468488480756,0.007795027910338745,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1196624131137735,0.11742055382311331,0.3091027263151839,-0.11154977991336222,0.3508746061409092,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08682607934395642,0.20534307067268584,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07463526623764481,0.09413785278769336,0.4285972581860521,-0.11073108301920746,0.2600016154944971,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10120107100102307,0.19408310698547931,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13627239185498155,0.2294895963440744,0.5531558925574734,-0.3156143615285729,0.588159145238536,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0715090296835809,0.17151382412474978,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09464162108340686,0.12071124966644807,0.4337316129571406,-0.14305026376726498,0.3323335059340787,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11554288041841311,0.28204953045896397,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13816859500969836,0.15484765855313362,0.3730608814349148,-0.16674111247747292,0.44307830249686964,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.138537090640524,0.2705176819974021,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10441451194582174,0.09437224909138513,0.26956731706042714,-0.08141338583596483,0.2902424097276083,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.04664956689878581,0.10788493777103264,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17174842431156037,0.17788726728183635,0.3351930449625261,-0.17852845516728236,0.5220253037904031,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1067960448758483,0.2771722260860844,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11425718248475686,0.11626310331065831,0.32664221227478474,-0.11467588084496447,0.3431902458144782,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11410482956297137,0.1861655521176797,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06965062134365449,0.14415962136138646,0.6293947605837552,-0.21421332849888705,0.353514571186196,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09819389775798518,0.2056211075039488,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0869592946123038,0.10426890995447892,0.40504888595317856,-0.11835606586062981,0.2922746550852374,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12793573500094593,0.2102865531737043,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08129209057191679,0.1571211378668082,0.6053257619653098,-0.22809431303702887,0.3906784941808624,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14597387099938985,0.26766613719864996,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06540649335051396,0.05249133264131764,0.2138656480842118,-0.03795391281141748,0.1687668995124454,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11691951053845315,0.21162907871749465,0.8289622204693651,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1097977952509101,0.08627107003053196,0.20425458499298393,-0.060078113583634185,0.2796737040854544,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.056779435887628224,0.18452219321060803,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11084599723971396,0.16246204876592732,0.495661571447493,-0.20905716584226347,0.43074916032169136,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14666356231028246,0.2562260036423679,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11576584560366125,0.13351255364712633,0.3866955268737753,-0.14713301937621692,0.37866471058353945,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11142629611001677,0.25357381631695297,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05848083763511139,0.08755681592076991,0.504775652877655,-0.11392682664835863,0.2308885019185814,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10381565774714484,0.13936356132339758,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09640375304331872,0.09710605695815737,0.3217426770193263,-0.09480727138547251,0.28761477747210995,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13207140902421777,0.17563741588962067,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06634267356816953,0.06437315975400044,0.3036847288856787,-0.06041417567332011,0.19309952280965917,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.043185948081305714,0.0912700180381645,0.8913059585247131,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005975338501746194,0.10338987145783227,0.9539567524153525,-0.19760911190521102,0.20955978890870341,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1000538840406286,0.036803985330298425,0.9945506567734527,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1590091626596146,0.08217035095019537,0.05405636963687532,-0.0027920418690621784,0.32081036718829137,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.015274971543641817,0.10683717789127636,0.5431638761740712,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007990860662763123,0.1057784385743878,0.939840255402868,-0.2162786259769491,0.20029690465142289,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11257253187810468,0.06484492176519124,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18503902869594005,0.07770831104401618,0.017973971173836128,0.03202400340498382,0.33805405398689625,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.008518265309616637,0.1950687119404399,0.3048662033716051,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01527093900065614,0.08924046389376891,0.8642610222457582,-0.19099386562490184,0.16045198762358953,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10346507389593826,0.005003276392222589,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19550366004036146,0.09023088440037899,0.031162378229717735,0.017830501621967254,0.37317681845875567,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.007303687828550615,0.17656849467445873,0.42195400245230363,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03203071821623947,0.08567718806522266,0.708816809891782,-0.13667578077371084,0.20073721720618976,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06543669523053118,0.01425081300485951,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021528756505173944,0.0800892642915179,0.7882886286181775,-0.17923210427397554,0.13617459126362766,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0739538436346347,-0.03966464174273175,0.9726336318937702,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07863745033764545,0.08455304905200853,0.35321140189409683,-0.08785551245229554,0.24513041312758643,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09958040385856018,0.154192062167134,0.9092831415853414,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10215212693241219,0.13982421827951996,0.465693858397768,-0.17317500357503227,0.37747925743985666,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1347608746697325,0.19358835227252308,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18609638803997194,0.1632170577708226,0.2552576429997294,-0.13529345929014866,0.5074862353700925,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14585711152480949,0.34440048044682625,0.8646722506638599,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005289609101852634,0.18797055028040838,0.9775714962338512,-0.36484220973049675,0.37542142793420197,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.16809832960772841,0.18828049778739825,0.9983210449785855,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0512349195773641,0.07799963993055734,0.511849075353539,-0.10235375988704123,0.20482359904176942,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08483650027227821,0.10305421791466268,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10125488785537978,0.11978337486870241,0.39870828453935003,-0.1346099236264799,0.33711969933723945,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11269500885839291,0.22311150056621956,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05477223158312674,0.1257230703009951,0.6634451350165174,-0.1927884028368745,0.302332866003128,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.17147221396494977,0.17518820815183328,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12309573531117823,0.1420312586539485,0.3869130867070739,-0.1565772667533003,0.40276873737565677,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.134676106548647,0.2624754967997639,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07322912159535248,0.13182602324310358,0.5790297457242648,-0.18634880526402875,0.33280704845473374,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11044884585628456,0.13988248039998472,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15681654958972965,0.14902639660643707,0.2936472553265759,-0.13663054171093728,0.4502636408903966,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12591276862662093,0.24187856093495885,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12320017409075801,0.09192586016560039,0.18134182640163318,-0.05781055216431205,0.3042109003458281,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.057478456319127076,0.1658049935023631,0.8014130815101496,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059750359824582856,0.18589947020172118,0.748155270463597,-0.3063033061517558,0.4258040258009216,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.18653322202292935,0.24453653824260374,0.9637098944799569,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11097509132084384,0.13638351988141145,0.4165592914988405,-0.15757697812386678,0.3795271607655544,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1390122259902975,0.3071762234119252,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007956147225876781,0.17605267664230664,0.9639889422823483,-0.35462054395564546,0.3387082495038919,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13206869477372712,0.08542376835928268,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11930509077549711,0.15893147202691965,0.45352749646357715,-0.19364603227687627,0.4322562138278705,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10072770778852977,0.2552684647404629,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02495938783349579,0.12730950295886312,0.8447213757815822,-0.2756438584301522,0.22572508276316064,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15695469582437394,0.1716717342678431,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.115354362231614,0.11958712516788633,0.3356354842210618,-0.12012401499977399,0.350832739463002,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1402046911554728,0.21245325497857648,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11930648085408063,0.07284868304284779,0.10268302031359378,-0.024139476578970087,0.26275243828713135,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.016442413805398844,0.07619712007289578,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03647667079133824,0.12827306400229643,0.7763543609334976,-0.21610514277223478,0.28905848435491127,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20993531445540622,0.0535182482246383,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10963279945596628,0.12493096068163145,0.3809966176372698,-0.13636809609168338,0.35563369500361597,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09788304831925257,0.17524246855458558,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0163856631592018,0.15225115809219,0.914377764472605,-0.2834112889693538,0.31618261528775743,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20484034349194688,0.2727438692917679,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09297725563511283,0.054645895918267476,0.09004941547263708,-0.014625689708074319,0.20058020097829998,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.06284583668770076,-0.019339386695992333,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07568048517433014,0.09667079704852083,0.4344143019136436,-0.11467347126280895,0.2660344416114692,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08186633406662092,0.11421027192637714,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09492242673764964,0.09562666686068202,0.3218069662782241,-0.0933755384554035,0.2832203919307028,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09800330660195133,0.22491793704906307,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07259805897803634,0.11841243315100416,0.5403474653020612,-0.1605672384005352,0.3057633563566079,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07081843750474659,0.08995213890288403,0.9481163084809376,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12637068949835298,0.0825590160460058,0.12706183781265173,-0.036195833419903234,0.2889372124166092,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1042046183288478,0.2670481985568486,0.7266692136576581,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06443536962172855,0.09534702132466619,0.4997669561090965,-0.12331194702175402,0.2521826862652111,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12664413698741628,0.11369031810639577,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11073699967050968,0.10426123297168347,0.28916707067412684,-0.09456324409610484,0.3160372434371242,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1247743590325682,0.19130095370063543,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14849080867524286,0.20658198086779636,0.47290812602711574,-0.2582886799335987,0.5552702972840844,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.13873820118664432,0.31995946370692474,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12673046439203847,0.1515463296499563,0.403779792594978,-0.17167861376956026,0.4251395425536372,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09558089621961957,0.21513953716700612,0.9235345118679857,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05953748061760967,0.08685180126959759,0.4936327180168416,-0.1114819430358649,0.23055690427108422,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06732182263297476,0.10330298892171064,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11898643962402175,0.19348491384214547,0.5391136500634875,-0.26200368340419133,0.4999765626522349,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11600925633513692,0.26530067630628473,0.9471659478826966,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12811481715673304,0.13754058565480728,0.35247171254264453,-0.1427156243977404,0.39894525871120645,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12602524635315107,0.23953651499696876,0.9090812501778921,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13417810817191547,0.11804488139578448,0.25671868125781383,-0.09826344498464074,0.3666196613284717,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0815189392440423,0.19444768368053073,0.8647791852375212,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08137574106211107,0.11257834379856045,0.4704275341409411,-0.14030168175297622,0.3030531638771984,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.18707179670444132,0.3046925134341706,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10662827453466583,0.16839043793830352,0.5271441169400071,-0.22494844838870293,0.4382049974580346,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0012730582497861337,0.07344324916847947,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10836471039022072,0.1863424825810258,0.5613817095740677,-0.2585612889248918,0.4752907097053332,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08449208643167802,0.16466493702162066,0.9509691818071948,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04651004749541631,0.15261116081016993,0.7607904733788551,-0.2539957840857542,0.3470158790765868,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07678903888303332,0.17928729380760905,0.9678132656540628,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09364996361984827,0.13931381203651008,0.5020363104408551,-0.18067212864736754,0.3679720558870641,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1265820242148317,0.23626497812694539,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15691955230398344,0.1395156025472302,0.26173017668527954,-0.117799884593253,0.4316389892012199,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,-0.00989193429552054,0.15805077247995597,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15837856443208834,0.17049488240477423,0.3537813824326992,-0.17734200898724642,0.4940991378514231,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.3889815735281196,0.6245440716297258,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06158058000725184,0.12787387451099622,0.6305129740772488,-0.19021519163510905,0.31337635164961275,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15995075339040069,0.24347512918050165,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06888836558561703,0.11857336432499882,0.5617574728055106,-0.1645938205186012,0.3023705516898353,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1587335462177709,0.23270868031843803,0.9512011132956789,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11971463537740408,0.13344902624939495,0.37050221184111365,-0.14305913813876914,0.38248840889357727,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.046858755139041953,0.12001519391445353,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0797265325165157,0.10205325207663585,0.435378317558922,-0.1212259877188759,0.2806790527519073,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1454477704649208,0.1997997882160708,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13583628080969226,0.14398787578719507,0.3463554528204873,-0.14768948572883148,0.419362047348216,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.05498247121911049,0.12435935575778072,0.9075908470661285,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15804547034903638,0.147325581791598,0.2843682208072474,-0.13205255547315914,0.4481434961712319,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0553848748988315,0.16037639328131834,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07354673684152542,0.12311491080215685,0.5507697066512693,-0.16887818446985442,0.31597165815290523,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09936535756144915,0.1855471721122692,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014676176939596199,0.09729517039960107,0.8802170398254127,-0.1769072297689872,0.2062595836481796,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.1094070916187813,0.03377424781722521,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13469397318489695,0.13257564823502402,0.31058062213518434,-0.12636003629108455,0.39574798266087846,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15049420233169,0.2576202801039341,0.897405574514287,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11747520848085384,0.1150117605253479,0.30800173151002247,-0.1089938423723452,0.34394425933405287,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.03902848233563471,0.12333930749576857,0.8963805860848156,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17847415598824953,0.2000002508943237,0.3730168175691969,-0.21534528285476048,0.5722935948312595,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15808725599209947,0.3696533515339028,0.91574265170323,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14628918649020012,0.14793337111410818,0.3236349551366319,-0.14500563408027906,0.4375840070606793,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09582414756901643,0.20689134186481983,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1271219133111678,0.16315330100062592,0.4365935644524781,-0.1941423908991366,0.4483862175214722,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11511470106468961,0.19716994932428333,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10116620812448364,0.1912187475886091,0.5972134165935759,-0.2753616188900899,0.47769403513905717,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14642366026043604,0.2663013779182892,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054502806972511135,0.09803274285128795,0.5787108361996667,-0.13853294975928732,0.2475385637043096,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15226232699074585,0.20153247993778622,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024908872174746945,0.11445021115799793,0.8278801536338861,-0.20045443478191438,0.25027217913140826,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.008614504409921099,0.00766027006432007,0.9814385692272681,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16421444198931345,0.1954055183979723,0.40146582839704215,-0.22055753333674855,0.5489864173153755,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.14408015798005452,0.2670990023451021,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007322683818265168,0.08906055170807879,0.9345336703698208,-0.16804597867034732,0.18269134630687767,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10625682048476011,0.04431398573279276,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061262473642323186,0.10235092094404136,0.5499899515038096,-0.14027618478938805,0.26280113207403444,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10682088199852431,0.1310258518816888,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020058878986181142,0.08307456570791512,0.8093910533518979,-0.14352281005132214,0.18364056802368442,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12226653843972497,-0.011746067112475056,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06223161634651723,0.10442209875295196,0.5517169953979504,-0.1433853873812719,0.2678486200743064,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09262227378384388,0.1406510725865061,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027735895052377026,0.09475969043253887,0.7699861758389686,-0.21432670153490507,0.158854911430151,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11080687512934285,-0.0986161059351305,0.9692333998776356,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0703599239883295,0.1033541598014221,0.4966235062729619,-0.13315420678440365,0.2738740547610627,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.10347988780556848,0.13518383702327616,0.9433351023677367,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03628430477289535,0.08698937329933427,0.6769394170463074,-0.13500601123850942,0.2075746207843001,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.12585862367554593,0.034631453329310884,0.9619695749374265,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07775497209348133,0.11351374625299844,0.49396258852315644,-0.1457643467594954,0.301274290946458,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08674246728377547,0.10021197530066929,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0617085380783774,0.08965932578727415,0.4919030573774401,-0.11483916729047153,0.23825624344722632,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08870682773358242,0.08674520274502234,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04902142415479961,0.10251518114277719,0.6329174129596875,-0.15284067816761238,0.25088352647721157,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.11647120352022197,0.11135904263889101,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017616240709064805,0.0852601245052896,0.8364696216270031,-0.15026902062543127,0.1855015020435609,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.08813718510165411,0.06443058784485742,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06781421099306013,0.08384962657133409,0.4193898959505834,-0.09729364630141259,0.23292206828753287,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09615806282614041,0.15070774082758281,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03788880911797234,0.10660989979094809,0.7225794488647488,-0.24781380032693243,0.17203618209098773,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.15044269750791087,-0.11118065138202379,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08121270616507,0.0914926263334846,0.3755505441861625,-0.09894494163690452,0.2613703539670445,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.05491585477199745,0.09858268181934647,0.9164018869766861,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10328837994066596,0.09457447778500881,0.2757795382492037,-0.08293772529478484,0.2895144851761168,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0725021702846907,0.12984667572444478,0.8716406527156833,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07651813093803705,0.10205369389766258,0.4540606729940495,-0.12443525928480725,0.27747152116088136,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.09058089491791965,0.11121334931645221,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05516256465776522,0.10030005176534207,0.5828065488831413,-0.1423377380944697,0.25266286741000016,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.0876019769138064,0.08981878255533307,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0829666777385553,0.11560132307386035,0.473586242564372,-0.14466327761841213,0.31059663309552277,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.07443269617697741,0.11812266315914305,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0594248959958487,0.08186301726405615,0.46854651392406854,-0.10177113939293107,0.22062093138462846,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.06802752166917457,0.08059268665084597,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09491875308341534,0.11818555625787122,0.42262847852503715,-0.13779980220188115,0.32763730836871185,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.20246194050596827,0.37078289936503384,0.9288749656602147,1.0 +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018169647676626266,0.07994511661537028,0.820386655463657,-0.1392498596635902,0.17558915501684272,258,8,266,3,log_other_mut_burden|lin_Lung|lin_Uterus,False,261,0.027175905065745715,-0.0635028097255468,0.9788034269246562,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016852288076850522,0.08138494687495933,0.836240707813955,-0.1776789122371724,0.14397433608347135,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0946211729370798,0.027539507904669844,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030067488631169897,0.07668599796815234,0.6955588718280852,-0.18160841416045756,0.12147343689811776,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17165141269633613,0.07897866935649923,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05562655285525813,0.051708275939666815,0.28377775354608775,-0.15780844004508332,0.04655533433456705,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.16410328756807757,0.06771882491791684,0.877125252431494,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04441137130374639,0.08339142472998759,0.5951332683847903,-0.12038029887881385,0.20920304148630664,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.02104492532534092,0.006069473997184726,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025688816386483928,0.06682515795593222,0.7012201989424041,-0.15774351416179933,0.10636588138883146,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07031177566740934,-0.010996387474392234,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006882621666582659,0.05756539624472533,0.9049924344218838,-0.12063889603897496,0.10687365270580965,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.18933954995161253,0.1472476353207281,0.9887719540319797,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.033516836045684964,0.07966461823684559,0.6745667405533291,-0.1239102079964703,0.19094388008784025,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07503628081688919,0.044679788203546,0.9604862397331528,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05792550626102866,0.048101050609979726,0.23041681365558903,-0.15297907433736335,0.03712806181530605,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1366602256941059,0.05243886442991818,0.842940686827401,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.049712636184788835,0.049702813517170874,0.3188473716072354,-0.14793148397144348,0.04850621160186582,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06782695485275714,-0.01887320127564012,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029109724324407334,0.07231909999237654,0.6878837802562583,-0.11380167588767875,0.17202112453649343,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03253564760523578,0.007812376460022516,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05690538815096246,0.04933496123205056,0.2505852912302109,-0.15439731476266746,0.040586538460742554,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0748152164050753,-0.025499884974479883,0.8577585765822857,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05779823859619937,0.08462450827674801,0.49567683756697933,-0.10943015571960638,0.22502663291200511,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.015122427943694007,-0.019228638038120128,0.9425014779477888,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04890452735337692,0.057133399165478986,0.3933975752136757,-0.16180712258029956,0.06399806787354573,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07825725479587634,-0.014986000856513026,0.9200851777021611,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06377053650104443,0.049979499046509696,0.20397771752441643,-0.16253614878588007,0.03499507578379123,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06625209325803352,-0.04704596987857328,0.8179445630780711,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051307340331092285,0.14704524416267045,0.7276436720537289,-0.23927207423615943,0.341886754898344,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09019905686583247,0.13829516214444454,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0019479453523943112,0.12485617504893945,0.9875733099220445,-0.24478315062709394,0.24867904133188257,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.39405716354152637,0.3882477641675385,0.9990191441902606,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030891557868369755,0.03944802949770389,0.43482257360376586,-0.10884569628711138,0.04706258055037188,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03607435705723602,-0.028382762982477862,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013534527989203297,0.05391649835141516,0.8021409710549048,-0.12008013315776345,0.09301107717935686,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08926223711478007,0.031088718950016324,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04134890810151193,0.043964718839773945,0.34849261311160884,-0.12822857792573678,0.04553076172271292,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04416581913506474,-0.03470942642346985,0.9086977961712401,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03426474470009806,0.05001586556158655,0.4943665644351315,-0.13310222167339103,0.06457273227319492,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08093883320339251,0.015379087230815852,0.9421219642690486,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09508025527318037,0.07368057238658993,0.19891081369498056,-0.24068209170789157,0.050521581161530826,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0849447659706385,-0.08382034972203146,0.8150559640549688,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05254438710363053,0.08716408452304313,0.5475500210820652,-0.11970252095669977,0.22479129516396085,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15666251928494507,0.16071541979848028,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.019040672266258676,0.052255147464321604,0.7160951842889047,-0.12230324457706535,0.08422190004454799,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17367033594872586,0.09753640569631303,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04929162257853921,0.10184178898931594,0.6290999045129438,-0.15196022743205534,0.2505434725891338,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10971035734955628,0.08120032252345276,0.9600602055593583,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04156976680828908,0.05227755147753675,0.42778549584078884,-0.14487661219355719,0.061737078576979035,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1349174415602899,0.037206575088375764,0.9299900056018157,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04191990153547006,0.04804644486884559,0.38435601063924685,-0.13686556197846972,0.053025758907529606,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04622930251306358,-0.0208765928669174,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07434131926156767,0.05279532754718006,0.16119733709514453,-0.17867135358470748,0.02998871506157212,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.16785882035606653,0.03839896611940553,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044400463792376554,0.03558375741912077,0.21408469294903612,-0.11471832723522668,0.02591739965047357,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.02632765548742455,-0.0388007086744878,0.8289622204693651,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06196035373782472,0.06286376632537231,0.32592375932825224,-0.1861868564060186,0.06226614893036916,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10083084097546881,-0.0024119868800143336,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014727889624026887,0.0447658848026904,0.7426222404139196,-0.07373498228062655,0.10319076152868034,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.015789115240817345,-0.0034362240326256434,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06021337048588186,0.05474111143119811,0.2731328100242959,-0.16838851210992065,0.047961771138156924,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.029713049287949784,-0.07877037138813794,0.8700354117066056,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003938321058581211,0.0697453723553479,0.9955022029171438,-0.13743156703028706,0.13821923124200328,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15004378520283498,0.08039682386994712,0.999543673283893,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06801479002345434,0.09274888825373502,0.46452210615082623,-0.1152683743114562,0.2512979543583649,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10488594312526411,0.10403423768161034,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08753957234409307,0.05583913886421403,0.11908444811201103,-0.19788455067710817,0.02280540598892203,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08806571654704398,-0.0486098276802561,0.7227005727164707,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0232599386125797,0.07047306423093551,0.7418256413051549,-0.16252334603248594,0.11600346880732655,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07372930185452878,-0.010261763296170711,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02222625035842723,0.0472984292919578,0.639107274340809,-0.11569374039437325,0.07124123967751878,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12178042666317482,0.08839463162780922,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01324932053554901,0.0710419127246081,0.8523080328647052,-0.15363684225925406,0.12713820118815605,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10350882021588795,0.0324857993018812,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06735926980950259,0.041866562382841255,0.1097684364000636,-0.15009272546408362,0.015374185845078436,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07986204929171575,-9.149875936715485e-05,0.6987504796661628,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031625825901685965,0.05785607229035767,0.5854565934638938,-0.145956511746204,0.08270485994283208,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0578610250826954,-0.0036312728967176355,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029530482043895877,0.04577105885530093,0.5198107190167529,-0.11997970100389946,0.0609187369161077,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05519633805526154,-0.01724123671388078,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022838362869055204,0.05595401929260043,0.6837438705668178,-0.13341035900067946,0.08773363326256906,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0934666015961852,0.029784949014766457,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0133782752842641,0.05936338453714215,0.822008240627844,-0.13068759476453679,0.10393104419600857,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.024674860790649608,-0.03443944353063649,0.9793038292216457,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028126820258374104,0.047474459210821635,0.5544452603953074,-0.1219421669765341,0.0656885264597859,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07088103933890891,0.00974501519747055,0.9491210479105492,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04213031400085838,0.04545163514213654,0.3554739322482714,-0.1319483125762875,0.04768768457457074,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.010307337798854965,-0.06920600696120212,0.9108386596575023,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011840496832818764,0.045028750211840905,0.7929516221265156,-0.10082282298528479,0.07714182931964726,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.004600137372198385,-0.03785481661318582,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004105154717012841,0.051598728987805445,0.9366953026791998,-0.09786025427713341,0.10607056371115908,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05397336612960111,0.0378746657355769,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04687374162883523,0.050908700291916166,0.35868389527942723,-0.14747556939580286,0.0537280861381324,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.051269200945235065,-0.03045587369644221,0.9133814160475374,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004879485773077781,0.045277440597349165,0.9143252209450451,-0.09435325459028956,0.084594283044134,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.024534203714767635,0.0037890265069781687,0.9895309118568834,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0021345017212297023,0.043505294379998234,0.9609352118437352,-0.0838372890939208,0.08810629253638019,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.01032441082756291,-0.014892040180496627,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07686791043049539,0.044538332075877186,0.08645562986807295,-0.16488111027321245,0.01114528941222169,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08454979913058583,-0.03411871060929592,0.65578639613287,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05596415436333787,0.08468034733207351,0.5097121138102398,-0.22330289349239388,0.11137458476571813,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.33396253243786145,0.31390526981991845,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.034567101621423985,0.0660861546729231,0.6017138966255915,-0.16516143838633834,0.09602723514349037,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.011249704144149626,-0.0866032992785913,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02347180367002171,0.09735479349658267,0.8098147773617872,-0.16891319361868573,0.21585680095872917,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12004222805833256,0.06745241826701606,0.9747331744048557,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004458025710228096,0.060607256575554526,0.941463024137027,-0.11530933728431556,0.12422538870477173,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0917519262188662,0.04842081927934111,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009870837458394273,0.05309016343116242,0.8527574401738449,-0.09504182868700449,0.11478350360379304,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.013939130032059011,-0.03679086391860822,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06025099692041568,0.0734465541964693,0.41334273653838016,-0.20539038474571716,0.08488839090488579,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.013056760739901866,-0.10368508184694006,0.9263451842579509,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0745855430039163,0.06874262957028801,0.27968721325663565,-0.21042939956720613,0.06125831355937354,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03791355407401084,-0.09053715148384946,0.8754562692551948,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06058296322702243,0.07636081079089105,0.4288279165386766,-0.09031535260664779,0.21148127906069264,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03955090400933321,0.06852564700121073,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0025866923087185523,0.05882547813163012,0.9649857454563633,-0.11365965822416847,0.11883304284160558,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03493479785906646,-0.021197510628148786,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.059321059470422155,0.05205736374625543,0.2563220422448488,-0.16219278692708974,0.043550667986245434,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03346542626288191,-0.0577175117316036,0.8646722506638599,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020635610028560382,0.049031547435286524,0.6744649517665922,-0.11752795381161038,0.0762567337544896,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08165845739763711,0.022061653833398864,0.9604862397331528,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031530299212971874,0.05181405879272318,0.5437702428555833,-0.13392122627815928,0.07086062785221553,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09236012750569714,0.0032455671477515102,0.9485922053772787,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007923722358289847,0.06460560114877405,0.9025525420875777,-0.13559230400114952,0.11974485928456984,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.105730322311066,0.04156979247758174,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005690088281728883,0.0714658043021364,0.9366472562734475,-0.13553509512317885,0.1469152716866366,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1597403010480562,0.12146876202458803,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0026789818058070188,0.07225975332834952,0.9704757007749787,-0.145473105740189,0.14011514212857495,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15647983217336073,0.10404026642138639,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04392163816604074,0.050436516749108234,0.385257242889817,-0.1435903734129563,0.05574709708087482,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15223821976901086,0.08292291411926297,0.9192918506885728,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01279824658327345,0.06624981034236206,0.8470815800233653,-0.11811949383122497,0.14371598699777186,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0973918548961677,0.0658350825729151,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04633526717945773,0.05154959814181552,0.3701935309467841,-0.14820358760371352,0.05553305324479805,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09923908130485246,0.017615705869445775,0.9150244079451123,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00940863068022095,0.049265524868469496,0.8488045748070152,-0.10676334253197939,0.08794608117153749,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15629878336175132,0.09969278751738225,0.9827611894425448,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0384716025137957,0.04841338017593351,0.42809063749924847,-0.13414237207082905,0.05719916704323765,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15844757139883547,0.09688178170387582,0.9299900056018157,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018514008094115582,0.04493192446675298,0.68090207586655,-0.07027697852552228,0.10730499471375346,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.04434560690268048,-0.03587417784269807,0.9621831471002781,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008662650083247729,0.05525563563731629,0.875636581233471,-0.11785455456450006,0.10052925439800459,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.022533087046379935,-0.05254313790577941,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03925469330968862,0.0393211245795182,0.31975821159238027,-0.11695805206505464,0.038448665445677384,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08703354989015126,0.02301300867845483,0.9027017389660956,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03361371810831977,0.08830214299932446,0.7039961298883479,-0.2081095691226656,0.14088213290602603,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0927933521621622,-0.025376917913850446,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017159844742379665,0.05072293356220074,0.7356124553499088,-0.11739457469619352,0.08307488521143419,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19502683837029278,0.14518890810365878,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011111727358429021,0.07132783305286308,0.8764156486123009,-0.12984080795731917,0.15206426267417722,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.02801643932326062,-0.08322066808519862,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.028268139454241746,0.04579222943335423,0.5379768728348696,-0.11875919406973903,0.06222291516125555,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.037092487084101795,-0.020651657796372177,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017400088220283563,0.05030942450723094,0.7299380202894359,-0.0820174971886958,0.11681767362926293,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.07340530038487571,-0.0818796820603882,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020010498752371562,0.04601921089045266,0.664319744815963,-0.11095009653087193,0.07092909902612879,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06597178837052022,0.0031277676675909305,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023188723783563084,0.03915002132081666,0.5545506954156119,-0.10055396154068014,0.05417651397355397,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03520190289907768,-0.03319229267404436,0.9491210479105492,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035212908697011915,0.05302263416175503,0.5076526426909637,-0.13999212873415814,0.0695663113401343,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.004699791213954131,-0.06793692481571924,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0003722616262561568,0.041690047388654054,0.9928875941113179,-0.08201237877785328,0.08275690203036559,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.022888334351820343,0.0024092377559345596,0.999521629637202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03103505644189559,0.04988595587629732,0.5348201332371082,-0.1296158159639516,0.06754570308016042,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.01906726887519048,-0.026285699611268948,0.9468590670943479,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006765804719112398,0.04540325703838073,0.881743987650535,-0.09648820223551177,0.08295659279728698,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.018885949505177343,-0.0026694083675296437,0.9867875051416815,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004232547452772118,0.04704040135387589,0.9284272583535804,-0.09719014267629636,0.08872504777075213,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07679476465810649,0.03626870806661778,0.9916960348989801,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02040803354103391,0.05813135935153015,0.7260369220586389,-0.13528272033933286,0.09446665325726505,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.019292783802222144,-0.02493962950624514,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08162475293709397,0.06691101359917623,0.22444309772532325,-0.21384911198022666,0.05059960610603871,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.015332568958398041,-0.11079814528121487,0.8368385672821118,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004362832886104746,0.06147223957085082,0.943515528187298,-0.11711384246202833,0.1258395082342378,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11637159660305368,0.07526014344502686,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03843381252792969,0.060849522095341425,0.528609187086131,-0.15867992186554875,0.08181229680968935,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04297542792011623,-0.03852709331454593,0.9450734236122966,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0314100492015625,0.0495638629531382,0.527235984842803,-0.12935431365313332,0.06653421525000831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09080397502033047,0.028177719196015187,0.9448126253726593,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003821291846691357,0.059504182534633236,0.948882602484284,-0.12140884541686049,0.11376626172347777,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.036699696030943633,-0.01570708380380706,0.993730344541434,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013338038271234847,0.05098584593085039,0.7939914254797045,-0.11409231527058382,0.08741623872811412,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.006669542354783039,-0.037790176527356376,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.056503998471915215,0.054759755557826806,0.3038243954433384,-0.16471598317395855,0.05170798623012812,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.060358926014279314,-0.044471743427715996,0.8913059585247131,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.053082234871436526,0.04630536834120529,0.2534997138892898,-0.14458731482508136,0.03842284508220831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0554274391210518,-0.03108527568778976,0.86289911185814,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021435508444057685,0.061292953707389054,0.7270443185887255,-0.14255789296461885,0.09968687607650348,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03452632074544087,-0.03740038480692378,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03804747773367378,0.067009239957748,0.5710348683029446,-0.1704659440934449,0.09437098862609733,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10806206042586282,0.05920034461576534,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050454004117137005,0.05133889166612021,0.3273275384672383,-0.1519059427352234,0.05099793450094939,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1459118386125224,0.042746470070514644,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03489427732917125,0.054065036612420264,0.5196589124099056,-0.1417334122964643,0.07194485763812182,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03500134706201524,-0.04753940840142421,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03590271194177031,0.05429735341724278,0.5094967336552145,-0.14320093337271522,0.07139550948917459,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0511923177177003,-0.013516179217189022,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.044809521713930045,0.06098978104626435,0.46368144763036934,-0.1653327999193971,0.07571375649153701,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11690809671250518,0.04926014898095562,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05269651862887173,0.048237739678502416,0.2764177103005444,-0.14802020104814384,0.042627163790400366,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.029442804045896633,-0.10063570900170682,0.8724468327497898,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013036052397436012,0.03917895832488075,0.7398082124382747,-0.0904584732191816,0.06438636842430959,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.009264186080077147,-0.038897966202326724,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08060393925026671,0.06895333779659626,0.24429765544472054,-0.21686418107915156,0.055656302578618144,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12679977875474605,-0.0009598101368781531,0.8528284808184983,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006898182547989134,0.09421953869973036,0.9417347379335872,-0.19308753230945888,0.17929116721348062,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.23652555437317893,0.16227955837214658,0.9928146453313277,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06320587916293621,0.059767344447369024,0.29199192699509663,-0.18131347290832223,0.05490171458244979,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10848560124265805,0.011644514402082043,0.8799526010712531,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003956815329968257,0.08025136415431357,0.9607424946887912,-0.16254334117766195,0.15462971051772545,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.2344485900629592,0.16420452601776153,0.9962057403241632,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0704229851511152,0.06717478583033129,0.2961843147313728,-0.20316859043342134,0.06232262013119094,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1139007847012737,0.009406102386131064,0.8833721946393759,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002411733857152036,0.0916424699073012,0.9790401297508837,-0.18350848001033926,0.17868501229603517,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.28545092956540735,0.21088452781902883,0.9984157213799838,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016378599293943894,0.04177232418252626,0.6955541883420383,-0.06616863013323797,0.09892582872112575,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05127045225861484,0.0425534867980457,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06998173665640493,0.04041315568145604,0.08541828382222542,-0.14984308263602475,0.009879609323214897,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09468435837825843,-0.016916842772516025,0.6528607274170573,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05940155131118607,0.04330262059586063,0.17220868738609627,-0.14497283390263854,0.026169731280266402,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.054071828677453825,-0.03616164956092936,0.7850787711519817,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02727300715878686,0.04866226767136232,0.5760166033936311,-0.1234356088939137,0.06888959457633997,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.033660436108538666,-0.01760655073905406,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022052974886037705,0.05554925881034565,0.6919404398219006,-0.13182511472415653,0.08771916495208114,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0503241927262717,-0.012298245116420078,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04437637252413154,0.06725635450642375,0.510401645951281,-0.17728316750203746,0.08853042245377438,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07796000986104197,0.018444897230327332,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05615373469554495,0.03917839573873622,0.15388605191760166,-0.13357504377815577,0.02126757438706585,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11597589403621188,0.032160112452809045,0.7711789647234355,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026362645520944087,0.04767587451225529,0.5811280118979808,-0.12057601354682303,0.06785072250493486,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03858548203508383,-0.02847994251264755,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03829975260407582,0.04271655396113726,0.3713873563179251,-0.122712895735901,0.04611339052774937,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.122320456886913,0.045825355025904325,0.915561182973695,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.030658581657510675,0.05428956455075859,0.5731169243210656,-0.1379414113341965,0.07662424801917514,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03804215492889676,-0.03938097647429427,0.9525219182038099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05136179296106954,0.053729165386233305,0.3406620113657931,-0.15753720524334042,0.05481361932120133,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12322859192940193,0.024848726296355136,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026710530842513687,0.05071732798522604,0.5992216677043426,-0.12693418348957822,0.07351312180455083,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03304614090285489,-0.03482151436711524,0.9533164021566217,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027065914432765653,0.06185836846341964,0.6623528800173113,-0.14930562777093412,0.09517379890540281,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.120048639390802,0.04597845906353259,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05093217626204011,0.07717027885062758,0.5102813719024184,-0.20343010013640916,0.10156574761232895,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.02427512756799095,-0.07607358931522909,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0007166247163690291,0.062094658864564126,0.9908074861436382,-0.1219900273985236,0.12342327683126167,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.12286876402890336,0.10102384888747223,0.9992761255456871,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018625540776734922,0.09985246166120297,0.8522841145290413,-0.1786951547536357,0.21594623630710555,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08106870701927614,0.007103956668336034,0.9832743004559027,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0025833114409375066,0.06612103042488211,0.9688876801377679,-0.1332465669637794,0.12807994408190437,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.125726251253601,0.08057221889666868,0.9969763314031036,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0042158022170484186,0.06648013600539104,0.9495220363372061,-0.12715708992101565,0.1355886943551125,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.020063276347940435,-0.01949562294457065,0.9937952805575481,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00302457647013543,0.04442443572997762,0.9458109631714845,-0.09081270318178115,0.08476355024151029,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.11789459165784275,0.0797271725811871,0.993077588787628,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09607514575618363,0.05750854166643075,0.0969093913129247,-0.20971906851754368,0.01756877700517641,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19183383157987413,0.056514611793098635,0.6747953931947336,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03719679540313371,0.04573796492619499,0.4173761693462231,-0.1275806167054293,0.0531870258991619,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.01201869657574681,-0.07706398003796774,0.9275420473817595,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08783797490029309,0.06242156161093413,0.16147252692476305,-0.21119062688550821,0.035514677084922036,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.18926425860838947,0.06091104787751831,0.7815068115919459,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04906996063402001,0.08236243841940945,0.5522316830343452,-0.11368830655459684,0.21182822782263688,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04077502557466336,0.023154547509649886,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027722088760694437,0.03696579239956462,0.4544819423096996,-0.10077102261534632,0.04532684509395745,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09470675268522792,0.051227185924938974,0.933731420853472,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08103481675581617,0.04089290501950164,0.04937250447237589,-0.16184420619363923,-0.00022542731799310434,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.040836004840310185,-0.0725022197293246,0.5240813480471289,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010299744410000538,0.05031751735945866,0.8380916607861206,-0.1097333222863045,0.08913383346630344,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04628214836075531,0.00781937354801529,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06601677733177942,0.04500312011248596,0.14451470017998957,-0.15494845526839685,0.022914900604838,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04609038623839988,-0.06103161409268055,0.7635967032883216,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02143459555267028,0.04872121012616383,0.6606195843131542,-0.11771367479855857,0.07484448369321803,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06320832000557007,0.022038511992665814,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017579497383345393,0.04470692289145372,0.6947254643355176,-0.1059258533289382,0.0707668585622474,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03313017672526042,-0.018393502330273388,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.032758015227359286,0.04488342955908122,0.46663759932150184,-0.12145316996912177,0.0559371395144032,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0281959894345265,-0.04252030182063975,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.046390857416445275,0.07224975556597499,0.5218079505702735,-0.18916522454771323,0.09638350971482268,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.030068132947036835,-0.0667037833903864,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03026568988507178,0.04887909942129547,0.5367399372452655,-0.1268567777185689,0.06632539794842535,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.0866205835484357,0.014229708736565774,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04902141643533503,0.04144843269140131,0.23882117436716885,-0.13092859660141815,0.032885763730748085,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09494020780298458,0.016327113260449805,0.8459452857747916,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022547909640534262,0.07490624470167179,0.7638254692148168,-0.17057182470686563,0.1254760054257971,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1423133081668977,0.06263345883140709,0.9681057644104086,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05073853924903031,0.050223219273669475,0.31401926995692264,-0.14998577255690254,0.04850869405884191,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.07133260742772361,-0.016375292251192095,0.9014294790115309,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0464993978963514,0.06367194327525119,0.4663633866460123,-0.1723229572140127,0.07932416142130988,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.14426524921620199,0.04043857129503273,0.937664825139976,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015771928639794597,0.05555763554826757,0.7768959713723284,-0.09401676465855477,0.12556062193814396,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.05380867715693716,0.02746430869558618,0.9700679690002965,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04770283244783945,0.07564207159992602,0.5292492626188918,-0.1971808315992094,0.1017751667035305,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.30700169641570807,0.18894706236459982,0.9450734236122966,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009737182413152275,0.07127358401007126,0.8915192109259023,-0.13110815014887856,0.1505825149751831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.21784620911491193,0.17738881849770627,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022007488937194265,0.05693041836408091,0.6996311257703056,-0.13450896923670452,0.090493991362316,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09212566597732581,0.0597516883180316,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01793180154953431,0.0660344415652283,0.7863447292485237,-0.1125603437800502,0.1484239468791188,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.051026360886108256,0.026706257570345088,0.9723925976809099,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06366324749675406,0.053197686118543065,0.23332544171088773,-0.1687883916432584,0.04146189664975028,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17732120057333603,0.07041091287549679,0.8449482942840995,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0720229344706008,0.09110071969055718,0.4304507442652271,-0.2520491158345657,0.10800324689336406,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.4181287794617788,-0.44514837381832306,0.9302388919528202,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.007212421498603402,0.04596156852975671,0.875519499164725,-0.0980381109115481,0.08361326791434129,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.0030777933943520264,-0.033357372840498355,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0173954069030578,0.044514502541611614,0.6965213113227373,-0.10536151666710059,0.07057070286098499,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.0072488545631770734,-0.04454618305521015,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0054043929956406386,0.0659450676732035,0.9347948546759819,-0.13571992456685408,0.12491113857557282,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.22014200391199926,0.1824042035163344,0.9921544029542516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01580785495911738,0.04509832267307934,0.7264470266865631,-0.10492766481717201,0.07331195489893726,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04781338783807672,0.01516340495633824,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050370759023461456,0.06120034060780858,0.4118054364601518,-0.17131012871473933,0.0705686106678164,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15216660343937724,0.06237032075088801,0.9258730384511746,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016796485722488503,0.06532163862664789,0.7974316272371567,-0.14588004513163771,0.1122870736866607,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19403619098229516,0.14384485163139632,0.9740375132149399,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.055062491384696044,0.048986738251406765,0.2628207530565721,-0.15186628673156125,0.04174130396216916,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.005204440083859158,-0.09214043776416334,0.8670850705749964,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010573016245025942,0.06917636762050164,0.8787314905766542,-0.12612795983562272,0.1472739923256746,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.01594042325113511,0.007425221122983536,0.986191362849829,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03193182517271469,0.05361147138940111,0.5523418225655254,-0.13787465970048338,0.074011009355054,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.019176377747032555,-0.06376946102668388,0.9486985340888475,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023187179204294806,0.06576140414533181,0.7248932940372816,-0.15313976914682645,0.10676541073823684,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19380300677285078,0.14797690579699652,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012447138201411485,0.07482490827015617,0.8681084092016218,-0.13541604611305244,0.16031032251587543,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.10307232625083075,0.05962764524134355,0.9858799847884159,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008147544369598187,0.06543400857758118,0.9010761356553598,-0.13745316056639176,0.12115807182719537,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.17505366555682417,0.12402728722092908,0.9882859306472693,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004028724491707197,0.07130785596380135,0.9550215900352816,-0.14494178263240376,0.1368843336489894,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.19257585336627248,0.15063406583243585,0.9948722834429907,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03583760158079298,0.0753426414756073,0.6350168057101377,-0.18472389012823426,0.11304868696664831,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.170285003561334,0.07316752587498264,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008026952266854254,0.04033538164303533,0.8425317768611725,-0.08773460721973254,0.07168070268602404,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04166823347997947,0.0010960701557094377,0.9824089645441008,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024118706245065895,0.08897837888706087,0.7867206134422425,-0.19995088220814947,0.15171346971801766,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.2936708346619423,0.17608645970291503,0.9724156299569652,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06323397584652113,0.06583861785491005,0.3384007869522132,-0.1933391495373649,0.06687119784432263,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.024155239419062866,-0.09565501451816008,0.9034998483867911,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0029933685938792007,0.046316248071037174,0.9485566787772071,-0.08853321103861074,0.09451994822636915,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.003592558895194235,-0.025846277007361876,0.993730344541434,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07503992785121391,0.04024165156140306,0.06419915484772255,-0.1545623606814514,0.004482504979023583,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.07855268492974896,-0.17805930049712365,0.5879399282333936,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0027140671863417837,0.04400526993907916,0.9509040981794472,-0.08967387095004402,0.08424573657736044,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15030083180207762,0.12584812702521198,0.9939790270408811,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0609532574611227,0.04138892071419135,0.1429567662673114,-0.14274283467040239,0.020836319748156994,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.14147076516509607,-0.21198996128200753,0.7607934302264618,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024847298731798438,0.05481137538118977,0.6509795716146782,-0.08346669306430829,0.13316129052790515,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.15985627910160125,0.17941535706449244,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0478765443504788,0.039156154376109455,0.22338349901544222,-0.12525390177611445,0.02950081307515686,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.06545557680441359,-0.13204590963914828,0.8355377918591873,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013543016872596665,0.038255956779956274,0.7238347243312826,-0.08914147357978634,0.06205543983459301,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1227001972650005,0.0786646062308877,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.060444526601748434,0.04906145938430638,0.2198967174276675,-0.1573959800600841,0.03650692685658722,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.022798596722753892,-0.11484438558077159,0.8339173235202663,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02987265306954079,0.04849521762234246,0.5388461943705316,-0.12570514344524195,0.06595983730616037,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.08687708009598612,0.04251009107855526,0.9471273828544232,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05609315166167089,0.05543564494280897,0.3132560452804967,-0.16564077658056522,0.05345447325722344,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.027297378383846813,-0.11123354153920097,0.9010715492787081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.017391348967938015,0.03965731768035497,0.6616338308672663,-0.09575906647206184,0.0609763685361858,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.04492044176508679,0.02533603671785496,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03304427719216281,0.03571528692720584,0.3563608349119832,-0.10362205905451241,0.03753350467018679,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.04997627185979195,-0.1049809348346698,0.9113377279417921,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.057616555793324614,0.05314093226052998,0.2800295452936831,-0.16262954736441054,0.0473964357777613,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.16233088199178428,0.06853905151469367,0.8758370884717323,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06088319550653311,0.052448341015902705,0.24758317708701358,-0.16452754194023833,0.0427611509271721,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.052592648620480326,-0.12477717225281312,0.855600896698613,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020697684839389024,0.04546248565085397,0.6495825199116481,-0.06914175567038365,0.1105371253491617,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.06094609777517061,0.060482583887508615,0.9604336667767839,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03935326600570777,0.059981359716979155,0.5127839045344735,-0.15788378013934495,0.0791772481279294,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.07258811177787079,-0.1437372900844564,0.9438759903131516,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.022114924184365368,0.061406689084721126,0.7192568508508804,-0.1434620637423909,0.09923221537366017,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.09175996461277434,0.06783467161956838,0.963305304214035,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08849148788778581,0.04218373893171342,0.03762565822627607,-0.17185172325503661,-0.005131252520535007,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.03391996801936138,-0.07204122147480119,0.46506124338146493,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012389340622275435,0.04745206788323931,0.7943847601323355,-0.10616043933433837,0.0813817580897875,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.022883576259937206,-0.025635751070682593,0.9732342286065081,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.050839387220187646,0.04461655188047344,0.2563464892623151,-0.13900715897821264,0.03732838453783735,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,-0.011410840330857196,-0.083988398827402,0.8646722506638599,1.0 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04062027260266765,0.04787209146280963,0.3975205206905833,-0.1352213893581633,0.053980844152827986,138,16,154,4,log_other_mut_burden|lin_Liver|lin_Skin|lin_Thyroid,False,148,0.1570149884737759,0.07742610066149914,0.9212557438608796,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10213021418073495,0.09673063507907151,0.2939732549112821,-0.09013239718579782,0.29439282554726776,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05031069141992622,0.10351134673125854,0.8803348634474737,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1231872547201742,0.08896983393267405,0.16971698616110775,-0.05364992401601304,0.30002443345636143,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.027898672116415568,0.16378377753049786,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08538567025739591,0.06773397590690683,0.21082223201530045,-0.04924294120012668,0.2200142817149185,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.02927502939685044,0.13408603804554817,0.8252886794984905,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1601672562981172,0.11295401950674212,0.1597666915832735,-0.06434108831225682,0.38467560090849123,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.18230956354276487,0.05893077537694716,0.7815068115919459,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12608955054157173,0.07376760143462158,0.09096384901273065,-0.020531544982843902,0.2727106460659874,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06901183872279044,0.08850530391633028,0.6643433245175604,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10489138646892238,0.06188311845659377,0.09365352847399021,-0.018108012265960843,0.2278907852038056,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.11401541392511068,0.21598170314013665,0.6704521782043941,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13482347063278938,0.07527773514557633,0.07676887019576781,-0.014799179161826742,0.28444612042740547,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08900806719281087,0.1143718694407517,0.630187478401246,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14224624513807227,0.07908279742363965,0.07553401759889292,-0.014939377952384675,0.2994318682285292,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05311423207975453,0.18625924825666748,0.6286648421036044,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13672385772320655,0.06314462823611687,0.033105965203679866,0.011217071703237602,0.2622306437431755,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04597614178053869,0.11451224510700458,0.43476822754237954,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18193483812315725,0.08960766062103234,0.0453751275612332,0.003829909778970547,0.3600397664673439,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.17680186484043883,0.09031532340632233,0.5099902114773299,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14895610381625318,0.07599093455221169,0.0531747522630172,-0.00208410702541581,0.2999963146579222,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.013897325444416297,0.14543206306226117,0.5411630668077272,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16904337901004296,0.09833593863648628,0.08916347381665264,-0.02640994700167179,0.3644967050217577,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.20505874411132174,0.04070760111427068,0.6623259037556665,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1539779546150697,0.07830998278382052,0.052456583608587855,-0.0016716156971494922,0.30962752492728884,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03995461702974988,0.13626181859415532,0.5393787055504797,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.108621763333562,0.06954321802925555,0.1219344684354053,-0.029602912749740667,0.24684643941686465,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03803269105288839,0.08205716026111957,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004175248611738382,0.18755627019120819,0.9822904882578338,-0.36861314728426425,0.37696364450774106,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.22652741158491665,0.2147195151931015,0.9987474789101741,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04727304209799877,0.11008928641258679,0.6686890808165148,-0.17154133528988985,0.2660874194858874,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.3188620428077033,0.3181338242937351,0.9604336667767839,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12434021985606553,0.05789413139438805,0.034516796721250464,0.00926936484117405,0.239411074870957,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07345770889726112,0.06779647302264481,0.44697280974434944,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11178338170279062,0.0798137758857829,0.16490447033833522,-0.0468551402326855,0.27042190363826674,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04570426040488066,0.10397046132849205,0.7824698350312412,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11328663338915446,0.05959036532893147,0.060600766790647395,-0.0051556702415479355,0.23172893701985686,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08536918483806188,0.06124997196812119,0.5719962981975731,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08842328380166413,0.0697065405465665,0.20800045924737068,-0.050126013469615774,0.22697258107294405,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.036489409159084024,0.07243699570386063,0.8210381131305959,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19148269432893664,0.1058148125116299,0.07381090801413757,-0.01883570333397372,0.401801091991847,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07664138247238177,0.13988123703665173,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08619132679437738,0.0995131420109351,0.38880115529730286,-0.11160181839350644,0.2839844719822612,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02689511755875322,0.12863209726905186,0.9192918506885728,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11190283428083311,0.06897581937016434,0.10834718182744676,-0.025194075528697346,0.24899974409036357,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007683128001878942,0.11281412115326278,0.6975344114730515,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11139909333856537,0.12075003579505342,0.3587882702156667,-0.12860467780985949,0.3514028644869902,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1355127330626821,0.040340835138383165,0.9133814160475374,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1275102261928946,0.07240377064986005,0.08173522014948328,-0.0164001079690429,0.2714205603548321,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05445225767765355,0.10932665279424353,0.6428846031996515,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12092672333992273,0.0754844152637464,0.11277845662942346,-0.029106725569208056,0.2709601722490535,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.060715351487891374,0.16744350096809904,0.7080335255008432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12573243781814192,0.07468855469966318,0.09587842599048028,-0.0227191520428269,0.27418402767911076,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.003549503111023226,0.13445559830531809,0.6734224093863465,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10477940109165168,0.07567817485039158,0.1697342269513552,-0.04563916597653231,0.25519796815983564,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.09979820616834392,0.16551125396491806,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09526600066903092,0.08030594244254717,0.2387380311487906,-0.06435075559059104,0.25488275692865286,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02920598100729413,0.08727209453226979,0.8459452857747916,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1139142315746719,0.06769857923719527,0.09602513201663627,-0.020644025168991303,0.2484724883183351,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.013462133595945074,0.09563054157136096,0.6734224093863465,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10623061602750339,0.07334198825137651,0.15109184549477636,-0.03954452720914087,0.25200575926414764,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05666966835981328,0.05552638479658642,0.7686319965021204,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14451087057471537,0.08337158370095571,0.08657900518357871,-0.021199179638500543,0.3102209207879313,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1033572705135475,0.12281760565110102,0.65578639613287,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1234303042707163,0.09552103053451313,0.199716823493216,-0.06642808708560446,0.3132886956270371,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.13424030940954837,0.07514671267340814,0.8150559640549688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11493685448027964,0.07696488409086205,0.1389589370028625,-0.03803918653026066,0.2679128954908199,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04900566998106405,0.07626254789285541,0.7544842968048717,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15002285843617508,0.0847194149331963,0.08009305402194591,-0.018366152296426658,0.31841186916877684,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10322493049270653,0.10079052667178244,0.6378354016929029,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05508389241937559,0.06122357523695244,0.37075448496050023,-0.0666045927500826,0.1767723775888338,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.04940529961082781,0.1277331304475027,0.9150244079451123,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12332477359130253,0.06873308941808869,0.07624594550679863,-0.013289684155292636,0.2599392313378977,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.045902108334942404,0.06834881315130042,0.6296189902384475,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01217073341921424,0.06475340470830086,0.8513495352854141,-0.14087513687852174,0.11653367004009327,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.055392687606844584,0.04649559049643923,0.9832743004559027,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08975679348272228,0.0671027592093569,0.18451245773796882,-0.04361720643927275,0.2231307934047173,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02778455492189885,0.07593042008753367,0.8047111541643488,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09934975106027939,0.05058789242828335,0.0527341913106474,-0.00119916287831362,0.1998986649988724,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007790730274725735,0.0859788230196526,0.5404408711479688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12534782146708542,0.06598118223084071,0.06077864935618311,-0.005796922763971174,0.25649256569814205,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.027066722102365378,0.1058409549131628,0.5729939650705244,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1159614455259753,0.06133986890160024,0.062023457095674264,-0.005958185894433199,0.2378810769463838,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.055583107804416214,0.06670088937271511,0.5802376411176683,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12113507872046027,0.07412454369488396,0.1058284079408475,-0.02619547819650199,0.26846563563742254,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016093791718494732,0.12114327036593318,0.688943585244993,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11162527925074653,0.07267713625394215,0.1281902889409859,-0.03282839864976614,0.25607895715125917,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03232087707924102,0.08491538906831787,0.7289215713564084,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0678978567006581,0.05731081339117499,0.2393504343964494,-0.04601359062024711,0.1818093040215633,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.035630249856109235,0.03484693709961756,0.8459452857747916,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14701705299556322,0.06430762467802376,0.02467462331192689,0.019198685616201527,0.2748354203749249,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.002652241075742893,0.14081958052393084,0.3709605300190827,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10464576212912327,0.08377517191496048,0.21496936304284053,-0.06186646336060028,0.2711579876188468,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05320475105700721,0.08197767813800763,0.8291675431652421,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08130746685512981,0.05872937399162011,0.16976359022652046,-0.035423523263156065,0.19803845697341568,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.004592380584858661,0.08985109286159196,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0931392298998669,0.05623473709224048,0.10127218545716311,-0.018633399257654365,0.20491185905738815,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.004087022491993319,0.0716875092817989,0.6834764281602781,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05782705988702817,0.06410522657582869,0.36951315080590763,-0.06958901934823271,0.18524313912228907,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007979258262566203,0.06038737700103657,0.9150244079451123,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16739686549017385,0.12589962697226997,0.1871239653422763,-0.08284227572888464,0.41763600670923234,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.08259376065359209,0.290111799044285,0.8085168201280608,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.054792070725046244,0.0796376194612096,0.4932721766392907,-0.10349632124209288,0.21308046269218536,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05070699099456412,0.05317674444623184,0.9421219642690486,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17199190655795224,0.0806484445243858,0.035773877277464304,0.01169439032400632,0.33228942279189816,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.043019672798222434,0.17328660380142957,0.45290755634531366,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15031260080996384,0.07361390170345104,0.04418953447675103,0.00399700014410076,0.2966282014758269,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.003327108037304628,0.141254609742903,0.5034452685637203,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12197744761823175,0.07612121653907189,0.11268959847560993,-0.029321712779462453,0.27327660801592596,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.015126903996203882,0.11963703978210659,0.7080335255008432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16057686305713945,0.08281707006294552,0.055750728714168925,-0.004031031256913342,0.32518475737119223,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1338874374991847,0.0633799235729837,0.5511199060187707,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1428686710168578,0.07183577771432702,0.04986316883121153,8.728431746984899e-05,0.28565005771624574,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.02710241634899806,0.14602935251460009,0.5251695931527756,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06813640882847996,0.12004337224615053,0.5717696288810042,-0.1704627919978484,0.3067356096548083,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10470970550922552,0.0382191688153071,0.9525219182038099,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13594751122645582,0.06758689596418244,0.04737311724361487,0.0016112370811478816,0.2702837853717638,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.052839529462781,0.08929986582689202,0.5160635391563032,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13790419763920567,0.06497113244862504,0.0366336218549299,0.008767036720098154,0.2670413585583132,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08269218287435373,0.07740882736107894,0.4586714357798637,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10184073689498313,0.061659682856373285,0.10220932332482349,-0.02071455939050003,0.2243960331804663,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05782553140530198,0.13670893717661212,0.6839279097893172,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10689654440786422,0.0641381399365466,0.09917822542439395,-0.020584953695734487,0.23437804251146294,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.0978662965469658,0.039572866793886184,0.6779844217208436,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10759024334930349,0.05527424055163811,0.05482400443762675,-0.002273294929678843,0.21745378162828582,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06902307602517271,0.08235451813298657,0.5490443949486614,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14580944479985877,0.10799448530730532,0.18046792049651061,-0.06884128856289046,0.360460178162608,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06066232920197762,0.15308659131085045,0.8012048953586696,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05204360028386355,0.06860173453848373,0.4501219666241737,-0.08430977541620167,0.1883969759839288,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.059178241707026784,0.13645452389887555,0.933731420853472,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15803144935308389,0.058163026185752316,0.007946705119094457,0.04242613682400062,0.2736367618821671,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.028126555609309146,0.16087167520712334,0.17920723078230624,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12035569957227202,0.08176991964461312,0.14466090298521095,-0.04217086989823385,0.2828822690427779,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.022179503728376543,0.139600566378706,0.7635967032883216,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11700386323989617,0.0756173484423615,0.12541737313041462,-0.033293804755947926,0.2673015312357403,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.07881578435388584,0.17588639255022046,0.7261583573371491,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10996888556770455,0.06210431146715019,0.08011109794505218,-0.013470158226790235,0.23340792936219934,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.002269079904797038,0.13587273246449239,0.6378354016929029,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11039647782960557,0.04670928504525784,0.020331927547065694,0.017556716046546572,0.20323623961266457,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.07652841137724267,0.19453757210072986,0.3287017803075021,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09994320794362402,0.06626447458949265,0.13511427218567182,-0.03176461052560009,0.23165102641284813,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.052257518624741886,0.05907321545859193,0.7471520865805139,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12859803567991152,0.07554239111561893,0.09226435635307662,-0.021550646512533272,0.2787467178723563,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03933076676910455,0.08883672744839893,0.6674195391201606,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10779496252031594,0.06043758515569259,0.0779798812474822,-0.012331282254383319,0.2279212072950152,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.032810358789098916,0.09108951434194573,0.6337247675321748,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20730398424322483,0.10592221778516998,0.05353799315813769,-0.0032278930308601572,0.4178358615173098,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10033793072792581,0.14933256785181775,0.5420721807261442,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10590711108623335,0.06511721057977636,0.1074799518672478,-0.023520395936109578,0.23533461810857628,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.06559517250576145,0.18553615814787336,0.695334847532366,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13281185136120038,0.08523296061794693,0.12281114316631314,-0.036597887027386006,0.30222158974978675,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.17455579568552926,0.0012224316870185316,0.7232009306040013,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13438146494744577,0.07404056701901508,0.07297441741750138,-0.012782179233099183,0.2815451091279907,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007253615769896801,0.12559715217359174,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0850663297011305,0.06386526214711949,0.18635040681786647,-0.04187279424834116,0.21200545365060214,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09946408124603637,-0.0029588902363910704,0.8085168201280608,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08980120576084999,0.060148305628221814,0.13905589152735934,-0.029750064629354173,0.20935247615105415,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08039020954039057,0.03843307374229773,0.7544946458948588,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1263889352242329,0.0548873896787623,0.023682279032504597,0.01729430494391848,0.2354835655045473,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08506590083700159,0.06631706286189495,0.3634085581572868,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1256185591739082,0.06215121591846934,0.04633555543079339,0.002086287703528103,0.24915083064428833,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08432471624135139,0.0604374727756956,0.5160097508806438,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06327426384418358,0.04184340920205666,0.13411525322398943,-0.019894042815744556,0.14644257050411172,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03028683097117315,0.040182067409501324,0.7444803357286909,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11588690158241274,0.07505939068114559,0.1262336477751092,-0.033301764946461726,0.2650755681112872,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.012184520684185782,0.09573933066024311,0.7263564310373228,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07769433008210608,0.05635485382127033,0.17153348238646388,-0.03431704408079231,0.18970570424500446,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.057036017847680545,0.034961104085300225,0.7848027568782422,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1284957287737568,0.0690163109435367,0.06600516765427918,-0.00868166242234314,0.26567311996985676,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.025642635279923363,0.12647439576444583,0.5947207955047311,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14689500269505168,0.07342328429186669,0.04854687300432523,0.0009582747750687404,0.29283173061503465,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.014016939320975107,0.12600006106709813,0.5221749023148153,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1445290035724349,0.08827654676598608,0.10519475054389103,-0.030930191849723898,0.3199881989945937,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1684528684179818,0.034800296672754256,0.6885877821127975,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07938579026030666,0.09154627519245591,0.3882367013433744,-0.10257234446085077,0.2613439249814641,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04464954011432024,0.08889455074748677,0.9192918506885728,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15095233171734596,0.0748493143817619,0.04680521658950808,0.002181214580892099,0.2997234488537998,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07963734867836406,0.09814288640599554,0.5160097508806438,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08602949078302236,0.06600402569587845,0.19587780893604997,-0.04516065730832344,0.21721963887436815,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.039609409988774165,0.11730022973605679,0.8150559640549688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1921396737100679,0.08939580552841674,0.03438615304702175,0.01445583030246081,0.369823517117675,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07218131157760876,0.15246912324828824,0.44600863216872333,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11427729724534674,0.06740038116507709,0.09355692991155673,-0.01968825854062048,0.24824285303131396,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016213981570451196,0.0981123237537978,0.6704521782043941,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13036685815325577,0.07545485942651099,0.08758194391910924,-0.019607845329016604,0.28034156163552815,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04466379346117894,0.10270339405397734,0.6570553152600204,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14306997350382109,0.07241810462139371,0.05136837708296925,-0.0008688509786447807,0.287008797986287,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.004090854149435378,0.15201318143002432,0.5316325649082267,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11617399011997627,0.08198788707841642,0.16006416043235694,-0.046785813227073744,0.27913379346702627,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09080992984161804,0.06726452966563644,0.7815068115919459,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08316577561188182,0.05557627468049866,0.13816177770015095,-0.027298088202946283,0.1936296394267099,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.03099927246502672,0.09331051480573184,0.751698554752432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09699177322747798,0.06375418202503666,0.13180097691858644,-0.029726566951421923,0.2237101134063779,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.09056525426353584,0.1573739040370878,0.737305253544566,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1327117781473847,0.07620367744343275,0.08512351770067807,-0.01875128222672448,0.28417483852149383,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09159199328671717,0.08029283739884306,0.6528603705391135,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15147559860213725,0.08167411392683507,0.06703607085220857,-0.010860546630289375,0.3138117438345639,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02988605457717733,0.14871732839376017,0.5974084401217474,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0895983512624432,0.06492005368130474,0.17108173140774338,-0.03943728507572511,0.2186339876006115,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02219593575198567,0.07027608026624481,0.7845446469755442,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08385298099148245,0.0773801754099206,0.28151434797373626,-0.06994849648409068,0.23765445846705557,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.015252068077949524,0.07308135792793896,0.8768618853741261,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07426082917768552,0.061707728176809064,0.23207503135441498,-0.0483899623845874,0.19691162073995844,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.023256711785882483,0.05995619490482835,0.842940686827401,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08346500288230085,0.07477812819293288,0.26742329537014153,-0.06516462399570166,0.23209462976030337,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.014763075493239596,0.0698803260736079,0.870012817074135,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06756084698068665,0.08027301169620638,0.4022979332479386,-0.09199045585478946,0.22711214981616276,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.09482675885587721,0.14909557758080833,0.9228083763617502,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09172041857745221,0.08315322483531443,0.2730563729596129,-0.07355561974605669,0.2569964569009611,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.012577117418240807,0.09374324114452834,0.8700354117066056,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12259972158391813,0.07709263403595543,0.11539668743984921,-0.030630236275462297,0.27582967944329856,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.11680747395045132,0.2174274929595019,0.7149749731852754,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07719257438057049,0.07930822123230016,0.33309090317335177,-0.08044110293884744,0.23482625169998844,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.01602271048320572,0.08434825529006128,0.9034998483867911,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10232582585817875,0.09117774378934454,0.2648364435921921,-0.07889981279412887,0.28355146451048635,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.12553147628376907,0.22697037000120873,0.8693121373799397,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0756274325272992,0.051924092456004114,0.14885413026233318,-0.027577323652251143,0.17883218870684953,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.035292989476662144,0.055935363371369375,0.7662201971017615,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06175190872596137,0.0565001306878472,0.2774322047657214,-0.0505482189400685,0.17405203639199124,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.019209687560530028,0.04254961286659829,0.8732184145243047,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0893153105652668,0.06606563746585314,0.17990586140821976,-0.04199729759032407,0.22062791872085769,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.006012447122537815,0.08901952869405412,0.7996039909621772,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10509357012549603,0.06707668851584828,0.12079930713075772,-0.028228611470174497,0.23841575172116655,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.031239760518847217,0.08975830195523561,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18232617446135194,0.07725941984226992,0.02051582290551649,0.028764711752089306,0.33588763717061454,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007918552887750183,0.19476401279083497,0.3296651866882387,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06714472313835995,0.08491709826253824,0.43126395822754726,-0.10163720461677389,0.2359266508934938,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08058478909743982,0.03953293827238658,0.9302388919528202,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07453119613458828,0.048947268434766274,0.1314645916260982,-0.022756799967516464,0.171819192236693,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.029965907717355036,0.11119631265989222,0.7364614878814166,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1144861341322016,0.06188262110709137,0.06770058442353329,-0.008512276066691804,0.237484544331095,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04614733869661719,0.08180215663777844,0.5997848651272403,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14107035651966138,0.056513115202148245,0.014437083899750267,0.02874442072547434,0.2533962923138484,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016061227767634016,0.14395008411198193,0.26284764219315965,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16032925108319673,0.07350438681230838,0.03186473210449298,0.014231323121926154,0.3064271790444673,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03888048287132045,0.13390837132442332,0.42726730311733996,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11418771137056485,0.06471517462983677,0.08116339655872364,-0.014440705668181592,0.2428161284093113,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05018155125752949,0.09773220365280726,0.6405850327149293,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1479517913437871,0.08363267321061234,0.08038722465504916,-0.018277202541058357,0.3141807852286326,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03578793603747932,0.12877001715396585,0.6387525418536338,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09387183593930573,0.07942185101928202,0.2404501507303844,-0.06398769288575257,0.25173136476436403,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0720340173672579,0.1542167133674339,0.8475547497769944,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16346270437447374,0.10659860030754766,0.12879574703762117,-0.04841355640261119,0.3753389651515587,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.11587234194361969,0.08183490785302362,0.7302718857033121,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12477243436111998,0.09353405689915971,0.18569241510736229,-0.061136631742273184,0.31068150046451315,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.031144707284100185,0.18699749536822258,0.8073060060237306,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17500152952674397,0.10499902722855685,0.09917113051028002,-0.033695406551531915,0.38369846560501986,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.18430832317862492,0.043759774255661577,0.6779844217208436,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1545005783423154,0.08765694814951736,0.08148679818873712,-0.01972709773848902,0.3287282544231198,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.027395564282304795,0.21265131097146722,0.6423457835374332,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09000959237423609,0.08147118466628472,0.2722911497750454,-0.0719232089793439,0.25194239372781607,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1141421651177255,0.0099597988921947,0.870021716674458,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11250888926206358,0.06762332039610751,0.09975885671075149,-0.02189978238579081,0.24691756090991795,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.001574738964874208,0.13118371992258696,0.6779844217208436,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12074529708555062,0.060549431053905936,0.04926588540568814,0.00039674647730075785,0.2410938476938005,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0333286615709749,0.13731801045987307,0.5240813480471289,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06731754349775407,0.05199727674632261,0.19887140864956004,-0.03603267438331555,0.17066776137882367,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09386519142191917,-0.0023152969748718973,0.8150559640549688,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13817857164413636,0.07723628472151456,0.07708916424041856,-0.015336907507517372,0.2916940507957901,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.024368864265610937,0.14919854221721665,0.6308595729282912,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12889858705166768,0.10482323229830286,0.2221336406706109,-0.079448937567374,0.3372461116707094,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.12242338339322834,0.06404036596376189,0.8355377918591873,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10760129380697701,0.04659309508199907,0.02329121841318875,0.014992472157128678,0.20021011545682535,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.01481358984603911,0.11944747317731957,0.36040095860407856,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08651443832773034,0.060713521349687084,0.15774589602974454,-0.034160259511342536,0.20718913616680323,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.02321566212818014,0.053644149824931035,0.780274991675152,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08946378785495049,0.07429223763133726,0.23177268539353252,-0.05820007891887863,0.2371276546287796,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007588262566149609,0.09730061984009564,0.842940686827401,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0806287780101623,0.06519012070040622,0.21948032437902482,-0.048943645771756195,0.2102012017920808,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.06605027081384067,0.019138822561074652,0.8339173235202663,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11102532557636018,0.061356930324738004,0.07382697581453171,-0.010928217269972645,0.232978868422693,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.021423777095782824,0.14697223400726223,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08446891274318921,0.05799594801524813,0.14886447445782244,-0.030804313830527175,0.1997421393169056,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.01762465840576307,0.05590425440046656,0.7662201971017615,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08952835743068324,0.06122450981997837,0.14726315313758723,-0.03216198532373714,0.21121870018510364,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.007795003094959328,0.08908411659675623,0.7662201971017615,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16104264572066357,0.10473096473874612,0.12775620505551388,-0.04712148713288111,0.36920677857420825,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.062055259550083036,0.12516534113489894,0.7288842902994255,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1794537732768949,0.07266790628595311,0.015483345821752464,0.03501844093719603,0.3238891056165938,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08164460996081095,0.1335564749646016,0.27154254286073387,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09597823602434616,0.06008824025256668,0.11382749245478846,-0.023453647927769106,0.21541011997646142,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.006013737401856301,0.10552459871078052,0.7095033877612622,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17485403510532424,0.09349866197039292,0.06482956528344315,-0.010984679744525772,0.36069274995517425,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07009097286667246,0.1663460096761782,0.588665895017662,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1764157920929611,0.07657694607066794,0.023618954554488272,0.0242108199041019,0.3286207642818203,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0031611670237371423,0.18436272673412313,0.3633474055300928,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11166426731888238,0.0703598235363681,0.11613029211745686,-0.02818350063314845,0.2515120352709132,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.04503711525379591,0.16544791158744834,0.7168291281713628,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09164964571224837,0.09972244417353701,0.3606119120550494,-0.10655951018737753,0.2898588016118743,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03180019706908296,0.1165042982699675,0.9133814160475374,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19782684893824404,0.07408195534920194,0.009041000207911947,0.050580940969858545,0.34507275690662953,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.013957745651057242,0.22108082620470568,0.19636616606057228,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1520485192431478,0.07926942724608188,0.05837547924649586,-0.005508050827986832,0.30960508931428243,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05161946894504344,0.17129426279794166,0.5641356117388143,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11217278961741803,0.10400595765039652,0.2837817546007292,-0.09455031314311224,0.3188958923779483,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.004823048579874946,0.14244700106120664,0.877125252431494,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12690734972169754,0.08182874384934745,0.1245584188482509,-0.03573613922529614,0.28955083866869125,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.11528105902804495,0.05725965117988663,0.7259506085296737,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10459909306208515,0.057638889190783964,0.0730115682443651,-0.009964440435111813,0.2191626265592821,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.022764536126778534,0.11314518843171238,0.6234452489529284,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048236491228107234,0.18568231173030422,0.7956475010713903,-0.3208272093116488,0.4173001917678633,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.34495056862696305,0.1859959766014379,0.9735235918682278,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0858223225985781,0.06123909927378373,0.16464281797852987,-0.035897018275049666,0.20754166347220587,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07868238144773163,0.04009647809001036,0.7824698350312412,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09304158733238137,0.060672328678716164,0.12877900488700586,-0.02755123561272893,0.21363441027749167,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07976209447810831,0.044145625390239834,0.7302718857033121,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12084942184803828,0.06458650017027558,0.0646889912537979,-0.007523240769255354,0.2492220844653319,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.05487489889759817,0.21600171269974577,0.588665895017662,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07943287685646383,0.05980616749061683,0.187595123882213,-0.03943835693798921,0.19830411065091685,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.028297623151883687,0.07803633354420744,0.8085168201280608,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10801867470074963,0.061942985379734875,0.08471918077835698,-0.015099716026362106,0.2311370654278614,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.017204742923624762,0.15037865607186995,0.651648117266083,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11541677615009978,0.07005263423326157,0.10304776106073163,-0.023820419799060924,0.2546539720992605,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.03956627637160921,0.19005218096833315,0.6839484127328216,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12783914481044123,0.06042010027469602,0.037216357481559374,0.007747653130013354,0.2479306364908691,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.08549260136752836,0.05419498713896726,0.4631727895701855,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11695525191124376,0.0729885896607995,0.11269699804035913,-0.02811747336006773,0.2620279771825552,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.09437061357285818,0.030017703323767377,0.7080335255008432,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1086935102125335,0.07487704349205047,0.15020206750532375,-0.04013272153317103,0.257519741958238,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.016939312445363924,0.09602491720207595,0.7680634195565342,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12165662614677422,0.07756935888393313,0.12042745726659122,-0.03252087396848599,0.2758341262620344,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.04621819150973527,0.1821999673977878,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14543754099333808,0.08553651062300091,0.09264729857385563,-0.024575535899170026,0.31545061788584616,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07427232842200614,0.15211996725710036,0.6679693515706321,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13944059543618784,0.07633583527044198,0.07117849001138045,-0.012285142929361698,0.2911663338017374,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.03151105153271395,0.20040835783229835,0.6185936355341891,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09353942987523074,0.07837602803300396,0.23592973738018191,-0.06224141252122507,0.24932027227168657,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.019859598068624442,0.1283633257809467,0.8449482942840995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16919735331367855,0.08705164960572938,0.05517090995284017,-0.0038272263686590924,0.3422219329960162,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.07334587148467982,0.15979355894153,0.5501842753839765,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12093050026482008,0.06163421556537397,0.0529511814966344,-0.0015741770221632118,0.24343517755180338,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03235547551094787,0.10087657780789927,0.5409607190737244,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1951870670171183,0.07804059588223744,0.01425402348418861,0.04007293234143727,0.3503012016927993,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03993315397227031,0.1798170919988612,0.26131279080251546,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13957667713038166,0.08058003798710779,0.08679092991976743,-0.02058487370355566,0.299738227964319,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.1334673468119465,0.051758966855539164,0.6563443622796822,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.082282454534126,0.06006936057791822,0.17427726789966919,-0.03711190402030429,0.20167681308855628,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.043272873342441204,0.03698101168331013,0.7896200758961603,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08568335218968981,0.07779206008025663,0.2737427819043106,-0.06893679066770278,0.2403034950470824,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.027970472053635544,0.060219646683014647,0.870270919138952,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05721258065293196,0.06396942046216993,0.37358948749912946,-0.06993356922613032,0.18435873053199425,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.01764153005794098,0.06362018814517846,0.915824547329523,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06274576214242089,0.09205730269638848,0.49730575194992044,-0.12022809507767271,0.2457196193625145,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.1321465181270195,0.10157581554640044,0.9438001947036577,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05464341524010119,0.0722390924517817,0.45143823968350905,-0.08893960317153862,0.198226433651741,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.029159172885353427,0.05330301713027465,0.933731420853472,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10645200236586666,0.0766328634333185,0.1683426808733264,-0.04586411163608142,0.2587681163678147,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.019231618986656013,0.08151265304954479,0.7842677313995,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061493822241155904,0.054834801497936604,0.2651873353936753,-0.04749628333543565,0.17048392781774746,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03187586250327746,0.0516403374690231,0.8693121373799397,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1230939230515885,0.07856722854166046,0.12080719819739485,-0.03306695105931698,0.279254797162494,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.021588117734342917,0.08062664051764552,0.7228579124835106,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09047354594198541,0.05581675149162286,0.10865743822350839,-0.020468291574163272,0.2014153834581341,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.00010039481389055497,0.09368053666497404,0.6983913976492675,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11703629068960988,0.06876671175147445,0.09233910213949008,-0.01964499508526918,0.25371757646448895,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.10160352745582654,0.018649703817591488,0.6674195391201606,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0660285799372034,0.05716593070555519,0.2512391558616217,-0.04759489735790501,0.1796520572323118,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.013539244842372074,0.07621815574111712,0.8585176148211594,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0957807539289711,0.05456775878786461,0.08273445855241737,-0.012678575345543355,0.20424008320348558,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.03256124754257037,0.035687619164391275,0.6457680747188683,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07669530100197335,0.06782375885437168,0.26124574434441117,-0.05811176378547585,0.21150236578942255,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.05230075191429863,0.06140708567376573,0.8669652730965864,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11640474132482309,0.10478371410738328,0.2696700778886585,-0.09186423661067342,0.3246737192603196,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.13562167756007845,0.17564011152072465,0.870012817074135,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0941222689277206,0.05579331728368601,0.09518962868936585,-0.016772990562660323,0.20501752841810153,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.04225125001827686,0.06374900256077717,0.6734224093863465,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13806796732408655,0.09167240767086243,0.13566342100000223,-0.04414086935572903,0.3202768040039021,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.006289979000256506,0.09520727568262065,0.7473242853882033,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07481095076765991,0.0682435241237404,0.27600110528901634,-0.06083044294551003,0.21045234448082983,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.01865777055030387,0.09601758692086268,0.8716406527156833,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1293809023762558,0.0672633197533391,0.05768769918291225,-0.004312229012654711,0.2630740337651663,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.0021525959455307086,0.11493481981246037,0.5623055122749077,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08593305318791938,0.05427445045315263,0.11698040116500671,-0.021943294011462458,0.1938094003873012,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.0778010268118688,0.017730816238593204,0.7176009922554474,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11728538192595817,0.08488474630007171,0.1706012512249256,-0.05143224280065156,0.2860030066525679,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,-0.011636385499692333,0.08880740007240279,0.7844207095472905,1.0 +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09703384877983096,0.06651193575959456,0.14819541727199184,-0.03516582556045944,0.22923352312012135,81,11,92,3,log_other_mut_burden|lin_Lung|lin_Skin,False,87,0.0362387347211516,0.13388261433610482,0.7662201971017615,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008170183373717041,0.10082960083477785,0.9354622151849985,-0.20644112691729966,0.1901007601698656,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.034385072387509846,0.04592480944079197,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05050068119089213,0.11832597775142381,0.6697784393294409,-0.18217507136846742,0.2831764337502517,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.004989903197189017,0.07254009688475739,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023670268265900095,0.07334701965127036,0.747092500218652,-0.16789956870909978,0.12055903217729957,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07216327919726606,-0.09627945563918644,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015960596891267692,0.12211859310218595,0.8960856269351191,-0.22417294006739416,0.2560941338499295,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.16278317483872753,0.24435552762999568,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03281805347790566,0.10556807885639001,0.7560737538666105,-0.17477061522304488,0.24040672217885617,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06351317635950635,0.07557054765239868,0.9654293488033827,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03599743334441853,0.058919035554318926,0.5415982872089032,-0.07986073405202927,0.15185560074086635,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.11831888861457006,-0.1170606488981793,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03638613973496506,0.11827128045393412,0.7585218970554479,-0.2689543357365997,0.19618205626666957,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07146875631544032,0.039760853927871875,0.9669418369722411,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.050411128276572,0.05454020500927835,0.35593619579964375,-0.05683652339240304,0.15765877994554706,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07364718509929111,-0.08484712295865546,0.9108386596575023,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.027545138789351685,0.06154059602874051,0.6547089021683047,-0.09346805515204748,0.14855833273075086,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0468218887941805,0.07207143781384222,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.042483485712806926,0.10526932125008993,0.686762456256559,-0.24948467859314993,0.1645177071675361,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.15179856293570054,0.1546595020528517,0.9631430579652833,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.039158049049243,0.06864250075167687,0.5687095538908578,-0.09582030332495181,0.1741364014234378,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.019193393397666014,0.06971323702806607,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03357027497454358,0.11037406406989518,0.7611845719556567,-0.250609414718215,0.18346886476912783,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.16500268771349005,0.17642108645953064,0.9680441569078666,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.002290633346084439,0.09084658169391424,0.9798976205059748,-0.18093100602470769,0.17634973933253884,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04561975342680364,0.05730921250501761,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03646238314148379,0.06902398766294426,0.5976378751002508,-0.09926612364391868,0.17219088992688625,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.027159947121909462,0.048650062971976195,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06426020147552165,0.07894886513389676,0.41619875571134934,-0.21950494956733085,0.09098454661628756,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10192419289880118,-0.14669064010642452,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07041610780165525,0.11921359305840154,0.5551009588992633,-0.16400504812101407,0.30483726372432457,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.3592686158311668,-0.38113090602386857,0.9497080900134104,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05277958769993032,0.06760791762081664,0.4354947736236702,-0.1857235397409724,0.08016436434111174,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05625394246036275,0.006280985197351072,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06310350287314079,0.08253688009715703,0.4450273720197676,-0.09919670419425064,0.22540370994053222,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03313304145802553,0.11719242556061035,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.010220348434959482,0.07442856485938995,0.8908544881067072,-0.1565763952613993,0.13613569839148035,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.062498043605453676,0.0615882939093179,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047211433197311053,0.06736378529261106,0.4838415402678886,-0.08525245796218364,0.17967532435680575,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008109627783167343,0.08384823041779309,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057751231808553655,0.1343884363749533,0.6676395620151567,-0.20650967828936953,0.32201214190647687,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.011772507539848815,0.08161538287017216,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03495049764296236,0.1181318717875784,0.7675029610711036,-0.19734356568743627,0.26724456097336097,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008443860196197178,0.06444731031647315,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02320372887148396,0.05589581486469972,0.6782912888499109,-0.08670958886069212,0.13311704660366003,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10501951627807972,-0.0864388584202036,0.9621651627753025,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0011934124495046258,0.09887532838378059,0.9903763754454831,-0.1932346571801429,0.19562148207915217,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.10222706203069203,0.12392297047075415,0.9991875531629696,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0240348719156038,0.06792396838951088,0.7236531162882145,-0.10953056115479753,0.15760030498600514,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.007743760464951751,0.028296627780334038,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03778729849893511,0.06362677633939973,0.5529486789612097,-0.08732815246988432,0.16290274946775454,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.001340966944573561,0.01778233429331988,0.9486985340888475,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025379111094044865,0.05478053411767009,0.6434310290787582,-0.08234112281950237,0.1330993450075921,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07855061259241139,-0.06472770158287981,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04910226176077229,0.0663759650589503,0.45991493392535976,-0.08141918344874494,0.1796237069702895,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.018096426579745552,0.02018916151446615,0.9366557334939974,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0280543249016095,0.07947741540159384,0.7243007935732159,-0.12822976242608775,0.18433841222930675,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.025891791065683793,-0.01648240247775032,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014856220702779623,0.05341854339569328,0.7810834143207839,-0.09018579983584366,0.11989824124140289,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08409404110476214,0.12249330763588864,0.971527114099096,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.026871404116274956,0.05487977765642004,0.6246779338391111,-0.13478679014691528,0.08104398191436538,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.060918170082257424,0.025216440338302157,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04555164896692397,0.11778647455070557,0.699177884443394,-0.2771665244845657,0.18606322655071778,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05078419487063243,0.008226841798541384,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01723783155780864,0.10801746442901201,0.8732960621025924,-0.22964296273173462,0.19516729961611734,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0833745647344035,0.0867841304501692,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02083482754479319,0.092348417845239,0.8216284764456324,-0.16075875002907664,0.202428405118663,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.013487445156712774,0.030765986850240547,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.041664316830990936,0.11802825675675857,0.7242872861673428,-0.27375463195891864,0.1904259982969368,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07823751094670642,0.052748930146461676,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.047272012111610744,0.05844177704261704,0.41910764909288034,-0.16219170018605472,0.06764767596283325,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05289351744928661,0.017389644480323478,0.9275566244234728,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004731738355032107,0.08770170897947252,0.9570020192917363,-0.16772456858045118,0.17718804529051538,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008608358547895423,-0.0037868376771660432,0.995747388821315,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05854085931845153,0.04722631393971458,0.21591591207221322,-0.15140650340898126,0.034324784772078204,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.030832055323249275,-0.03362872795909269,0.8295752524063543,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023366430010506416,0.06079054650397336,0.969359509240254,-0.1172016564079018,0.12187494241000309,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04525562056013043,-0.06314087914962796,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02363803165410355,0.057482315816010716,0.6811473411183482,-0.08939497551396214,0.13667103882216924,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.032029936112596004,0.031947252310682066,0.9621831471002781,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013466887629371309,0.07223309179256358,0.8522046169935691,-0.12857198930965144,0.15550576456839407,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.03484442085599225,-0.029349734269783753,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010641269617536225,0.05746263608960451,0.8531847017414478,-0.10235303941138249,0.12363557864645494,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07281968801985976,0.08801008384441618,0.9832743004559027,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012075529002082724,0.07814462110239688,0.8772777215561582,-0.14158775668538684,0.1657388146895523,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03823806984474432,0.03292209300221184,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014032540453426876,0.06796588831666792,0.8365416882095673,-0.11961532380228009,0.14768040470913385,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03949477786241074,0.011998951990397088,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01545907587624407,0.0789584692330227,0.8448840272255949,-0.1398045576795541,0.17072270943204224,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03219654831897155,0.07167091914176803,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.008350347006449214,0.07997164820419016,0.9168955312196534,-0.1656062918371979,0.1489055978242995,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.035959473194315576,0.028784022297310138,0.989733344444655,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020981920844247326,0.08466901686803828,0.8044180439998794,-0.1874747535476294,0.14551091185913476,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0673179132198479,0.04661334256844314,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024175206397363102,0.05603535688923591,0.6664086596081692,-0.13436291903579403,0.08601250624106782,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.042616731970039894,0.03440659499462233,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021585033681104888,0.04904460878916179,0.660114259044001,-0.07485609848490661,0.11802616584711638,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03971805451096379,0.04494549565038734,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0020757674123662306,0.09696665327921605,0.9829325105106099,-0.19275062557665976,0.1885990907519273,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.022198593925590645,0.006473573716220284,0.9987610176465104,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05476720144174069,0.08565091638936592,0.5229431997886063,-0.22319083762888975,0.11365643474540837,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10464863722609608,-0.18922519457757847,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03700034317616366,0.05116883812089697,0.4700734225777681,-0.06361786546758014,0.13761855181990745,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.051222807390143885,-0.07948126193063626,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03419745939341398,0.15178068221071642,0.8218637719611931,-0.26426349675893435,0.33265841554576225,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.00937932306088742,0.035167458021800505,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05293229298369778,0.047256066741337095,0.2633907329028418,-0.039991856902768075,0.14585644287016364,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0025611611120997884,0.07965454772726195,0.8670850705749964,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10640854219855965,0.07077819415416348,0.13358676116048518,-0.03276942955848579,0.2455865139556051,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07106844681093788,0.17600549848737518,0.7439137251825841,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01610440996960004,0.1031061905834283,0.8759665008203688,-0.21885203093518518,0.18664321099598508,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.13624083249467334,0.09735160619204279,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028704505458649172,0.07830413301238587,0.7141439950589524,-0.12527244384186773,0.18268145475916606,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.018480226124354734,-0.01777323127750073,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09701115823254237,0.09158821734057125,0.2901951159598465,-0.08308756396061671,0.27710988042570145,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.17900909516205912,0.337455109539724,0.8780447660402404,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07414918276077044,0.07278840984407538,0.3090134569770177,-0.06898166948241367,0.21728003500395454,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07077948804356302,0.14682948097423906,0.8972291390434742,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00351291126141412,0.09328893334524226,0.9699820682211386,-0.18695591493693614,0.1799300924141079,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08490624069131837,0.08642026052724244,0.9969763314031036,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02062650760255002,0.05927880084352261,0.7280699202871312,-0.09593910089010455,0.13719211609520457,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04771263928721623,-0.07833566859606529,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.004671647164858281,0.07191706246728749,0.9482418734811646,-0.14608908524077763,0.1367457909110611,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.054867736138944,0.10073739630097543,0.993730344541434,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012540770937064072,0.09514468747829088,0.8952083012363719,-0.1996329224808532,0.17455138060672507,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.017409303334035873,-0.036318570745787385,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05957077756773209,0.09254493147356585,0.5201715342786215,-0.12240922365737665,0.24155077879284081,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07864040777409069,0.17865245321262788,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01541293110828576,0.0980824087374091,0.8752181279314792,-0.20828180656143414,0.17745594434486262,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.023666679559054767,-0.042676086336141554,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01273263984267381,0.06312848416283122,0.8402667537366628,-0.13686825097090402,0.1114029712855564,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0432864550300385,-0.08895633167012838,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01300048104121361,0.12177121647702539,0.9150360315954147,-0.25245093792551887,0.22644997584309162,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.031773314036882216,0.021301176953517416,0.9895309118568834,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08653523680908098,0.07064125271471314,0.22135608187937586,-0.052373453822330274,0.22544392744049224,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.08085632682993542,-0.06472933360074953,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0014866972994988792,0.09054815311985613,0.9869090847746997,-0.17954024116526365,0.1765668465662659,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.05926161742730285,-0.11067025549028019,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0470237704130618,0.06674486256542536,0.481545866109098,-0.08422307344996727,0.17827061427609087,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.07315371528249894,-0.08036662625801656,0.939653659088992,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009024005653768204,0.07641812191391614,0.9060626074687204,-0.14124429859676962,0.15929230990430604,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11202663986946206,0.13142066432369384,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04806395841385009,0.08623840170545251,0.5776333600671306,-0.21764282349186184,0.12151490666416168,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07609569974320979,0.011694806250755963,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.009657356260735876,0.0726692445142628,0.8943489159812467,-0.15255388225266037,0.1332391697311886,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.015568302325502806,-0.015203697295310306,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03365153037696479,0.099834044151292,0.7362517106990127,-0.1626617542911324,0.22996481504506194,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08092279672272869,0.16465703777000162,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03494476136635742,0.07447608668064845,0.639197465323733,-0.11150473218864053,0.18139425492135536,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04485106150534635,-0.05912337665076374,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011961097788874532,0.07736103084082388,0.8772099424132567,-0.16408353456662536,0.1401613389888763,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.1365927030835513,0.14358321260822915,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028564860320461207,0.06260379990005145,0.6484563696423964,-0.09453901366924478,0.1516687343101672,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06592739472427366,0.09670801151689062,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027902323829265097,0.07973561201353419,0.7265861850741153,-0.18469412799254772,0.1288894803340175,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11456593309696884,0.10109619586600031,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015731756026108976,0.06981503368558004,0.8218432412802941,-0.15301577270142358,0.12155226064920564,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0418666650816041,0.01645877205896667,0.9793038292216457,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005035043942799598,0.08497196122152484,0.9527807084113449,-0.16205349738493185,0.17212358527053107,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04188528698692188,0.04553459037213163,0.9940904623189993,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0081038719677008,0.08462556543471964,0.9237618305451916,-0.17451126193788666,0.15830351800248507,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07186088900653735,0.07925444662571351,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02078890015355661,0.07543683833713594,0.7830243472884006,-0.1691276121113426,0.1275498118042294,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.042201183407292196,-0.015443654275525485,0.9718034799423088,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021110979019062327,0.08403091452899765,0.8017767478827174,-0.14412709167205842,0.1863490497101831,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.034797359290237,0.043624206292689885,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0028146219435486626,0.08513061355414861,0.9736426590436773,-0.17021513661466617,0.16458589272756882,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.049898758379072226,0.014114494699437444,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.032493317249471285,0.08602904591819152,0.7058687729095987,-0.1366738714048228,0.20166050590376533,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.01372757444286451,0.05434780909809622,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013904546414880495,0.06652769006359234,0.834560214656697,-0.11691525026662981,0.14472434309639082,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.036389803644825414,0.0565450229359481,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.033027734377870197,0.13842227870858484,0.8115468577035705,-0.30522077669662545,0.23916530794088503,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.15318117004878656,0.1727588566496136,0.9759216719362132,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03375107974079766,0.07611600426378279,0.657723787320947,-0.11592314151171992,0.18342530099331525,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05877296632837891,0.1431632049706206,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.028307100201511004,0.08674030051409586,0.7443492774039957,-0.14225869678468295,0.19887289718770496,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07524786208831179,0.11853890924176012,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002443347666007751,0.05348434343054392,0.9635872255372966,-0.10272806181085416,0.10761475714286965,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04859720421040743,-0.07278148062713888,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053607539351494496,0.0981409283197733,0.5852369153543495,-0.1393764087858167,0.24659148748880572,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.09153511985801677,0.16754179396624067,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03217667711866206,0.07366139357769225,0.6624976169332237,-0.11267080701763094,0.17702416125495507,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.051711190167245624,0.07119603024218059,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04494634648644985,0.08245011629281707,0.585989929117052,-0.11718324856612161,0.2070759415390213,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.017390503884341563,0.07335455290166328,0.952608653969109,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01660227336915815,0.06238609742866733,0.7902939733484763,-0.1060735113089197,0.139278058047236,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03593818135034909,0.04908647538731718,0.972929334907502,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06566758520391673,0.09278607542414283,0.47955785786047855,-0.11678660056833774,0.24812177097617122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08534285987231476,0.1737971719975595,0.9384017168502401,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05088533478173035,0.048388307770119335,0.2936676159731366,-0.04426524955688878,0.14603591912034947,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1128590586228275,-0.10765149984948941,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09597651236793392,0.05924267610250478,0.10607197043198308,-0.020518060571395283,0.2124710853072631,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.13461932434493007,-0.07446664147785476,0.6895981173538752,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017317737035873818,0.09430266373857775,0.8543965105997733,-0.16811866222905242,0.20275413630080008,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.09166256771301805,0.12284698947147417,0.9834313824125731,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10408455243421627,0.09250870487297215,0.26126221021124557,-0.07782421294128458,0.28599331780971715,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04640603419382078,0.16271439533819643,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011804460711158246,0.0654686213783597,0.8570101539493004,-0.1169327873362201,0.1405417087585366,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0633194672845057,-0.09234263911707279,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.002099996449802237,0.07525583988246205,0.9777531533403998,-0.14588280083519906,0.15008279373480354,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05263280748493283,0.030611706041981664,0.9983210449785855,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009081847809741361,0.07413159319882891,0.9025617865619211,-0.13669023507299877,0.1548539306924815,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.02745494341533705,0.04892233674790126,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.029032671453447262,0.08119389340312486,0.7208674336947383,-0.1886920345941771,0.13062669168728258,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.03676062566739035,-0.12420355320006143,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02754631764149776,0.051055442734165554,0.589840674321152,-0.07284891074511333,0.12794154602810887,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1585182912110226,-0.16077662500213058,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.021652962753171093,0.08818451293365656,0.8061732726427115,-0.19505865354766122,0.15175272804131906,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.007437290654141485,-0.06778888557275983,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05447792167057104,0.058693242753639206,0.35391905791004463,-0.06093624762149595,0.16989209096263802,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1703957863182623,-0.13864457580268708,0.9094475823584263,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023781537487670715,0.1047225346510316,0.8204784583971607,-0.22970753127950472,0.18214445630416326,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.026035621325192403,-0.11946733477571078,0.9788034269246562,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06340763176455613,0.056304265816920565,0.26082754760162474,-0.04730886236639202,0.1741241258955043,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.15715404443042363,-0.11781205596889165,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.001803277750201615,0.07780425897358154,0.981521492646301,-0.15119072114184265,0.15479727664224588,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03995832597919639,0.016186238697448528,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05712221791035992,0.06856915362896687,0.4053483189139958,-0.19195634078145726,0.0777119049607374,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.008956296609773526,-0.10959477706097387,0.9237532919369174,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01946052114687622,0.07810790023475213,0.8033836183483052,-0.13413055676613636,0.1730515990598888,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03280808261864398,0.03486772113885199,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0170658346076506,0.07954922241018293,0.830250589177426,-0.13935945374859512,0.17349112296389632,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0320861389019726,0.02083263604498136,0.9817239773275311,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016210576501964877,0.12399843936177954,0.8960582866721462,-0.22761948299095996,0.2600406359948897,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.014993616404705583,0.032011190183677624,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03202855121764372,0.06788245602275488,0.6373307553768138,-0.10145525209267428,0.16551235452796173,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06670541016627705,0.09365655047912723,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004484952916022002,0.055801698630555646,0.9359840121422999,-0.10524329501133464,0.11421320084337866,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.06326616424663173,-0.1033423787818097,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04012864580791414,0.0625917810029286,0.5218436706386058,-0.08295159426820722,0.1632088858840355,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04226823683642783,0.08204327503710494,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03257028893071709,0.0838073176056458,0.6977711884584353,-0.13222810162084764,0.19736867948228182,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.004448857977014022,-0.011330581801971988,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026875991787412346,0.07586836178557489,0.7233570383530744,-0.1223112662379453,0.17606324981277,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04754782109812619,0.07442701884349269,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.013545784174131902,0.08082597981991547,0.8669958600597487,-0.14539011509605307,0.17248168344431689,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0311214908848599,0.026213699863051262,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020220364466316046,0.08377643719612149,0.8094090388220706,-0.1445173029654237,0.18495803189805576,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.052853336330151046,0.07238445146499098,0.9747331744048557,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0019257551134509443,0.06389844302756782,0.9759734460508062,-0.12372390019761031,0.1275754104245122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0754290823151869,-0.0954468995723256,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059567372638680824,0.07028529986756646,0.3972597600476858,-0.07864137366808273,0.1977761189454444,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11737368197828092,0.18905407568328264,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05782256284026921,0.06629615536673097,0.38367266405974476,-0.07254194489404983,0.18818707057458825,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.01943384995435447,0.10508774691577849,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003568821045704197,0.08410433557981518,0.9661762044959801,-0.16895126661187188,0.1618136245204635,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08362027023693573,0.0914773680150826,0.9962117873342113,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003410958545822823,0.11215953471646473,0.9757551366334305,-0.21713912388564918,0.22396104097729483,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.021106168872076198,-0.004851931046331817,0.998018743752871,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018528372964744504,0.05598171168753669,0.7408530733855823,-0.09155385195312192,0.12861059788261092,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.079241776606212,0.12218519966534057,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005679457350752801,0.07519987214866185,0.9398379626944262,-0.1421932851953951,0.15355219989690072,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.006289016788689062,-0.04488212593728981,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03816102310518274,0.048092763435815984,0.42800220619230267,-0.056408403978660523,0.13273045018902602,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.16562661859398736,-0.15107109965447918,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06470419206967239,0.10708517419361953,0.5460603184919516,-0.27527607127098935,0.14586768713164455,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08935022526433835,-0.07819580049210925,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00904546606381422,0.07583010259640678,0.9051135507083354,-0.15815749136512286,0.14006655923749445,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0038911160245537575,-0.019226438732108095,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01348556067250703,0.10690519914026221,0.8996856324251186,-0.19673241626848129,0.22370353761349535,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11531037730464741,0.1589938379900629,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055431712145767004,0.10745135641853146,0.6062482584053568,-0.15586022638972452,0.26672365068125853,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.023796085633300466,0.07288069886530094,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.023619056339727818,0.07936777504457847,0.7661831233268153,-0.13244943460698688,0.17968754728644254,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008584426277569114,-0.0009673782914911278,0.9686101294099047,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05026632041804627,0.0669595266899371,0.45331212788517117,-0.0814026381628784,0.18193527899897094,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05188986031754048,0.12684740434133251,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.007866584641287023,0.0895877969141743,0.9300762564106455,-0.16829851843464974,0.1840316877172238,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.02048112262807675,0.004348686077624714,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06395455396035499,0.06471018160120962,0.3236403975841975,-0.06329130099420588,0.19120040891491585,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0242829086675589,0.0973551680531557,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.015701518819055727,0.07752632483780915,0.8396125952779405,-0.16814898908372936,0.13674595144561788,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.003973035232247274,-0.06428983425590062,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022631043128759736,0.07477892372354512,0.7623348064361442,-0.1244139480354518,0.1696760342929713,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.056206206450575405,0.0664932616985687,0.9681057644104086,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07718196590185354,0.09809843527758418,0.43191383392120497,-0.115718424078933,0.27008235588264007,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08210734103843144,0.1747802924451049,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04312137935773073,0.0947358889234665,0.6492505357323433,-0.14316691226284897,0.22940967097831041,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04660702701100221,0.1044501983840712,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016850984613308598,0.03975159720747961,0.6718798962144439,-0.06131640492745147,0.09501837415406866,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.00638455885193975,0.0034595905678368837,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.005803525342635479,0.13178861808188494,0.9648989688951133,-0.2649521626383169,0.253345111953046,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.054606166406262154,0.0742575944229756,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014439966153421642,0.08273719809785791,0.8615459049360912,-0.14825414546857388,0.17713407777541715,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.01415843396812083,0.016282447550417592,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0063853358079093425,0.08449451505510716,0.9398012445942124,-0.15976435719429896,0.17253502881011765,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.08329166235768647,-0.111916389229897,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.014225831008675999,0.07187147064872175,0.8432051484603297,-0.12710195548863887,0.15555361750599087,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.10067169314698664,0.11858687892123793,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04576237798352247,0.0750598802030384,0.5424491675200562,-0.19335984090030098,0.10183508493325602,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.1006846092474461,-0.176034347224946,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0016258860541052411,0.09359928229461599,0.9861502380894502,-0.1824273866149529,0.18567915872316337,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0024156110059073387,0.005873380142711375,0.9990098172080826,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03856942614411068,0.08463515417568208,0.6488629718106169,-0.12785681908982985,0.20499567137805122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03301388880378731,0.12944145691078868,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011708117324082369,0.08459077233406158,0.8899925452560941,-0.15463085562531628,0.178047090273481,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11802232315671697,0.19620883470151812,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04429966187325365,0.11098371635043136,0.6900095687375166,-0.17393829579585493,0.2625376195423622,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.03420304894469407,0.035473223668509746,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.240300884581995,0.15225266928087794,0.11535048177688859,-0.05908818514976377,0.5396899543137538,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.09482547507469895,0.2634949692661065,0.7149749731852754,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.038765954574060804,0.09667919925138042,0.688669887985631,-0.15134365508332087,0.2288755642314425,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11463096094305093,0.19387991485347672,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0316864002200894,0.0791219797278456,0.6890375893580453,-0.12389875975076359,0.18727156019094238,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11810109273097448,0.18185667931445645,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.037616409255314065,0.10453164809991934,0.7191596424172817,-0.2431670444591395,0.16793422594851137,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.10130430001896303,-0.1902102637464522,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06330646397696085,0.10984654007543343,0.5647511211349019,-0.15269535459060873,0.27930828254453044,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06647238549929033,0.13676082272742263,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01796224961080456,0.11251154177148166,0.8732454304025165,-0.20328001815468033,0.23920451737628945,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.04803548729968856,-0.07080058420304507,0.9858799847884159,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0046455475030627025,0.11342156542608671,0.9673512809702988,-0.2183861873152689,0.2276772823213943,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.08047701258278321,-0.12252714316979318,0.9962636332708761,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.006780247332956676,0.07643302766260615,0.929361695257367,-0.15707786219101974,0.14351736752510638,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.07984301452498746,0.09925211394849325,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013328977881167308,0.094788155241389,0.8882477731599574,-0.19972004579049799,0.1730620900281634,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.08212245254349688,0.0473293303001813,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03798795056404976,0.08991969872553332,0.6729308332519779,-0.13882980297124775,0.21480570409934724,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0527383116490391,0.06308786541884154,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0053382039830911915,0.0608542660598065,0.9301457942883202,-0.11432539331807365,0.12500180128425603,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.06792150019855571,-0.06926008203474748,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01315660304108146,0.14842813535629681,0.9294163327234176,-0.30502512381139285,0.27871191772922993,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06266867682840864,0.06561130657724262,0.9916960348989801,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03266142470861984,0.0898915002769234,0.7165563636476928,-0.144100879504593,0.2094237289218327,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.05356655683072149,-0.05375944904910537,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0691746665089093,0.09053548801487186,0.44531765256232514,-0.10885397274259023,0.24720330576040883,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03255357823400227,0.09582627321962052,0.9330352189956562,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035962874353545504,0.09913460980610803,0.7169852593469469,-0.23090079398579716,0.15897504527870615,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.012320530637226896,-0.02529805779560166,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03258306706361253,0.05229638235562826,0.5336379399996547,-0.07025234027432853,0.13541847440155358,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04707518766570305,0.06657027180245098,0.9464658142652354,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010183032130557504,0.08706774597113374,0.9069589529390607,-0.1610266523568113,0.18139271661792628,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.21203489692085875,-0.245140607414293,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0023916341491332996,0.1268587833818428,0.9849687524240547,-0.24706299494460243,0.251846263242869,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.11833157010453954,0.13442000544871063,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.039517511123536575,0.0806095782898171,0.6242592881934164,-0.19802787924808915,0.118992857001016,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.020809207772301035,-0.05887801778065112,0.9593389007132584,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.023892766297510873,0.07375884380471477,0.7461734029371608,-0.1689318761895376,0.12114634359451583,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03709408667359678,-0.008772363179942403,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.016757008748738866,0.0841113893712469,0.8421969486220998,-0.18215332486354652,0.14863930736606878,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.013018276940982048,-0.08524217251834446,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04437830407519269,0.06892564078072747,0.5200666129233273,-0.17991342192549814,0.09115681377511275,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.024974640417107775,-0.024746284700646704,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0472872305505576,0.0858740269471587,0.5822003670679452,-0.21614959048987742,0.12157512938876221,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.012746119270544731,-0.16129069481992997,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0151322966164232,0.07350215731730929,0.8370013578264548,-0.15966665917600564,0.12940206594315923,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.0313613676578291,-0.00901731298974202,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0019109849422478675,0.07604281128262258,0.9799645137630474,-0.15144127979502514,0.1476193099105294,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.021106728972992667,-0.04862246375448109,0.9984157213799838,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.027259334409322024,0.0717453310790941,0.7042036742281264,-0.16833908053673366,0.11382041171808963,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03552393390393304,-0.010281849219528627,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01607000400024906,0.05053764900719059,0.750678860719046,-0.11544704477173212,0.083307036771234,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.016620300314139174,-0.0328533707409012,0.9646550643928868,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0691118138366017,0.07270632668420078,0.3424476598195124,-0.2120812580664382,0.07385763039323481,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.06971133630176095,-0.01037598251587987,0.9045618832985359,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.020463722200149248,0.05464959785322009,0.7082816070608446,-0.12792648354134034,0.08699903914104186,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.008501919075217973,-0.03857131653643536,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.029990541708869684,0.07627961767480143,0.6944234166175833,-0.12000540833271857,0.17998649175045794,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.047977711729786356,0.07508605004969932,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08471325266055865,0.11936228902125559,0.47832766505292934,-0.3194268037589711,0.15000029843785379,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03110924068690888,-0.1664770281463176,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02247735858354335,0.04733143680360414,0.6351435686718716,-0.07059499870667008,0.11554971587375676,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.0053265639058155245,0.00040653276963929265,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0012685778050282037,0.053981026604034886,0.9812637571238885,-0.1048795075748916,0.10741666318494801,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.04254523449976809,0.032029625912471556,0.9987056728178246,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.035900274240262604,0.06516978384815204,0.5820531998169416,-0.16404988930496558,0.09224934082444039,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.03155453877919928,-0.03039745836793113,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02744072305106876,0.051857829286506424,0.5970166647789261,-0.12941376130206678,0.07453231519992924,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.013983880165355962,-0.04132691706152281,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.011365426699639254,0.08067018544152647,0.8880354293186526,-0.16999497249677428,0.1472641190974958,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.016408024689353717,-0.007210250797700164,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.031000133239421083,0.06642956970692511,0.6410166158193502,-0.16162698642481338,0.09962671994597122,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.05008752943398095,0.013538391202427018,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030153766124821207,0.07209683621276515,0.6760144398097451,-0.11161717836037796,0.17192471061002038,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,0.030169673910327915,0.06792516225452595,0.9619311554974709,1.0 +ENTREZ:7157,ENTREZ:54790,TP53,TET2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.00428387548899763,0.060722825746014245,0.9437955910852531,-0.11512125807910177,0.12368900905709702,368,8,376,4,log_other_mut_burden|lin_Lung|lin_Lymphoid|lin_Myeloid,False,370,-0.06885382001474316,-0.11306247144826376,0.9928239334792922,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1277275849981476,0.09794598836449189,0.19736442642429042,-0.06833261241294164,0.32378778240923684,54,7,61,1,log_other_mut_burden,False,58,0.038612770297665036,0.18586831256414588,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1329429599818308,0.12612760647140134,0.29623794181532104,-0.11952887512536303,0.38541479508902465,54,7,61,1,log_other_mut_burden,False,58,-0.09777430270469711,0.11332240281223707,0.8833721946393759,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04385396331413623,0.08620433456592137,0.6128775034890128,-0.1287027603955741,0.21641068702384653,54,7,61,1,log_other_mut_burden,False,58,-0.041509506699537596,0.0531128018852726,0.9552369178668337,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.017506902076000835,0.10708054692653714,0.8706987811023008,-0.19683810091868292,0.2318519050706846,54,7,61,1,log_other_mut_burden,False,58,-0.01604302567593418,0.15363727301901595,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05284278951884384,0.10578187680170931,0.6192854094559641,-0.158902642780835,0.26458822181852265,54,7,61,1,log_other_mut_burden,False,58,0.02950533814121752,0.16312435016097296,0.9576211468940484,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01780448536401381,0.0667246262775935,0.7905424273053865,-0.11575936567890173,0.15136833640692934,54,7,61,1,log_other_mut_burden,False,58,-0.033995778261221944,0.04097355107877482,0.972929334907502,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02960631411343408,0.10792171251354606,0.7848046953466389,-0.24563509297069488,0.1864224647438267,54,7,61,1,log_other_mut_burden,False,58,-0.06646262707579995,0.03612647920584349,0.9721878388985049,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06985727044257953,0.08831778199982286,0.43218046015681555,-0.10692997794739326,0.2466445188325523,54,7,61,1,log_other_mut_burden,False,58,0.040242557970548376,0.12992700223359083,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07785442494045637,0.07966223665012159,0.3324762579235555,-0.08160686698820742,0.23731571686912017,54,7,61,1,log_other_mut_burden,False,58,-0.023138155312741552,0.09412852204223353,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.010120007059102635,0.09759934528601952,0.9177736348731667,-0.18524630884105053,0.20548632295925578,54,7,61,1,log_other_mut_burden,False,58,-0.061180848829625475,0.09507895554313316,0.9901412236863718,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07317585142749329,0.0604886526680637,0.23128445644136364,-0.04790534221055817,0.19425704506554475,54,7,61,1,log_other_mut_burden,False,58,0.050317742665108196,0.18069311265635046,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03717600226985267,0.10149236674760971,0.715478815097085,-0.24033504729582356,0.1659830427561182,54,7,61,1,log_other_mut_burden,False,58,-0.06290614346393598,0.04016075941593162,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10039605800714067,0.08741090262245993,0.25545520676436956,-0.074575874077154,0.27536799009143537,54,7,61,1,log_other_mut_burden,False,58,0.0006390228561503131,0.1661784840343193,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11715218079959162,0.0898214207319036,0.1972907867235607,-0.06264492753022517,0.29694928912940843,54,7,61,1,log_other_mut_burden,False,58,-0.035427248512324275,0.12966366658805847,0.8150559640549688,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01445731292135044,0.1216495493372547,0.9058096531031338,-0.25796534276812166,0.22905071692542076,54,7,61,1,log_other_mut_burden,False,58,-0.14677095504252988,-0.14750474138366473,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14552488896502191,0.15884803392104294,0.36339407260778056,-0.17244399785682518,0.463493775786869,54,7,61,1,log_other_mut_burden,False,58,-0.10792583792987667,-0.04400390746287575,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06511462719188899,0.05863835328336072,0.2713901108899815,-0.05226278981689936,0.18249204420067733,54,7,61,1,log_other_mut_burden,False,58,-0.07986314374722189,0.019826589969810432,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04718480977763156,0.08766243631763383,0.5924602116268072,-0.12829062170214436,0.2226602412574075,54,7,61,1,log_other_mut_burden,False,58,0.061362713825196084,0.19295975805333418,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05558249695711344,0.07251333593554306,0.44647914241831477,-0.08956871541876012,0.200733709332987,54,7,61,1,log_other_mut_burden,False,58,0.011596914773846334,0.13410738686414123,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03531357622083004,0.07266541353271531,0.6288159178940513,-0.11014205254025003,0.1807692049819101,54,7,61,1,log_other_mut_burden,False,58,0.026210530166706162,0.13451255150933608,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17690890277435395,0.16014299468555893,0.2738542571187548,-0.1436521296511069,0.4974699351998148,54,7,61,1,log_other_mut_burden,False,58,-0.13600617774999663,0.15084953325337552,0.870270919138952,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.011682637955959472,0.07808413018220142,0.8815866102225097,-0.1446197306640258,0.16798500657594476,54,7,61,1,log_other_mut_burden,False,58,-0.0035028043278469635,0.09935017340170771,0.9867875051416815,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0300954423070466,0.06551392310150861,0.6476822423225373,-0.10104492302018965,0.16123580763428286,54,7,61,1,log_other_mut_burden,False,58,-0.09763668023198736,-0.013387869263085701,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.08157354596531194,0.070819220811886,0.25410616640106276,-0.2233336184780063,0.060186526547382435,54,7,61,1,log_other_mut_burden,False,58,-0.04737232999906851,-0.007409328478365261,0.8638521408529491,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01195628418071665,0.07468024097087227,0.8733588187972523,-0.13753245989085774,0.16144502825229104,54,7,61,1,log_other_mut_burden,False,58,-0.03444796424610952,0.07443136250011327,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07068366041443966,0.07286969818790058,0.3360739535606668,-0.07518088851266733,0.21654820934154664,54,7,61,1,log_other_mut_burden,False,58,0.10838419778656104,0.23803642229791147,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08282200869557801,0.0690132745097725,0.23498414227769415,-0.055323069528748325,0.22096708691990435,54,7,61,1,log_other_mut_burden,False,58,-0.118506282832496,0.018325058793577504,0.8449482942840995,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.055343130339194385,0.06569011036023638,0.40297563175400186,-0.07614991210432084,0.18683617278270961,54,7,61,1,log_other_mut_burden,False,58,0.2200816903536499,0.31390803808954254,0.923447045283853,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09665608829505261,0.09562822141146896,0.31633493702676396,-0.09476459448199658,0.2880767710721018,54,7,61,1,log_other_mut_burden,False,58,-0.06965100930179734,0.08567347046954835,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.02541273159381657,0.04569007049925396,0.5802149807143504,-0.11687134456400165,0.0660458813763685,54,7,61,1,log_other_mut_burden,False,58,0.11984368642967497,0.1708173392249502,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1083394907511006,0.06966510748691726,0.12535124481819748,-0.031110372940318834,0.24778935444252004,54,7,61,1,log_other_mut_burden,False,58,-0.05867043996874139,0.09021387720718203,0.7261583573371491,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03934270833174483,0.12254062367939736,0.7493201139894645,-0.2846344172688562,0.20594900060536653,54,7,61,1,log_other_mut_burden,False,58,-0.14240024019802974,-0.044575515547419016,0.964192424193284,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.079062978574785,0.07221507447240373,0.2781184075574184,-0.22361715576504584,0.06549119861547584,54,7,61,1,log_other_mut_burden,False,58,-0.06212457162079632,-0.020576678994931524,0.8739920503526474,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1277269993430528,0.08922226050217091,0.1576366786907355,-0.050870759479103606,0.3063247581652092,54,7,61,1,log_other_mut_burden,False,58,-0.02452102326461716,0.14765272802082227,0.780274991675152,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.057336073742314704,0.14853062934067057,0.700892852937069,-0.23998028394000093,0.3546524314246303,54,7,61,1,log_other_mut_burden,False,58,-0.13068074096176982,0.0010720938959506235,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07784286217500411,0.11119160677895865,0.48667693578046256,-0.14473132120463933,0.30041704555464754,54,7,61,1,log_other_mut_burden,False,58,0.29266739573909345,0.3390715224502311,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01607783934534628,0.09613079647980412,0.8677554089554702,-0.1763488567330849,0.20850453542377748,54,7,61,1,log_other_mut_burden,False,58,-0.005901677738079895,0.05880516550225882,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10194683862419088,0.105374618130532,0.3373258993878515,-0.10898337687282258,0.31287705412120437,54,7,61,1,log_other_mut_burden,False,58,0.46603573364905126,0.48785216129892817,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07099314316216479,0.05998314144417208,0.24141890743527705,-0.04907615982059116,0.19106244614492074,54,7,61,1,log_other_mut_burden,False,58,-0.07410662284569873,0.03441958587630371,0.8487082760058587,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08487466131657846,0.05825835226521334,0.1505459788532222,-0.03174210101019127,0.2014914236433482,54,7,61,1,log_other_mut_burden,False,58,0.0059192666794947125,0.132633728164304,0.7680900043895489,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030081842532103553,0.07727977936884335,0.6985101806177048,-0.12461044300139645,0.18477412806560356,54,7,61,1,log_other_mut_burden,False,58,-0.07190145270394699,0.03827042428004652,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0861941250195627,0.05146257862193664,0.09934020121065472,-0.016819418387166704,0.1892076684262921,54,7,61,1,log_other_mut_burden,False,58,-0.022279140140474833,0.08721498067889764,0.6779844217208436,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08576365295490915,0.07307837029934722,0.24535826363135013,-0.060518598586134065,0.23204590449595236,54,7,61,1,log_other_mut_burden,False,58,-0.021117988639277392,0.09886634403425203,0.8538596653685477,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07759415800956078,0.07718954232563542,0.3189559401300885,-0.07691749845683234,0.2321058144759539,54,7,61,1,log_other_mut_burden,False,58,-0.020440495351519965,0.10248530673204238,0.9027017389660956,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07219733878313253,0.07028418527473662,0.3085817972071527,-0.06849174374021089,0.21288642130647595,54,7,61,1,log_other_mut_burden,False,58,0.0371010116872385,0.1330284824172728,0.8969323713769235,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07986580712476923,0.06801960078496183,0.24513011695331405,-0.056290217031067846,0.2160218312806063,54,7,61,1,log_other_mut_burden,False,58,-0.04232153033272888,0.06931609543523888,0.8535607195906675,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06778840741137368,0.060854820698934706,0.26990142294566727,-0.05402575117620731,0.18960256599895467,54,7,61,1,log_other_mut_burden,False,58,-0.056917453190856476,0.0818913679258004,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08390840916592847,0.046861627298440095,0.07858368587087854,-0.00989532953285674,0.17771214786471368,54,7,61,1,log_other_mut_burden,False,58,-0.035167070608583144,0.05681907629957683,0.6337247675321748,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04100554003896161,0.05657876032645449,0.471518278691779,-0.07224915373776514,0.15426023381568835,54,7,61,1,log_other_mut_burden,False,58,0.02797267836248005,0.04860911871589306,0.937664825139976,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09877309998742541,0.09386044786952556,0.2970082174200147,-0.08910899958270634,0.28665519955755714,54,7,61,1,log_other_mut_burden,False,58,-0.03604621738257807,0.11469925604261004,0.8843360296870468,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047553458699972746,0.060798154923007434,0.4373062408377004,-0.07414727101318197,0.16925418841312745,54,7,61,1,log_other_mut_burden,False,58,-0.2775415376673824,-0.2264220999824211,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07235066738973908,0.05722427500485465,0.21116703919869212,-0.042196164405013656,0.18689749918449183,54,7,61,1,log_other_mut_burden,False,58,0.2753661884725152,0.3596181296360905,0.826142906436283,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11485018767773207,0.14709612410743714,0.4381051913396341,-0.17959469579812232,0.4092950711535865,54,7,61,1,log_other_mut_burden,False,58,-0.1729340530385872,0.03979425508390675,0.9302388919528202,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08148084188392932,0.0843766680975937,0.33821383115552506,-0.08741740990094352,0.2503790936688022,54,7,61,1,log_other_mut_burden,False,58,0.24029795907516915,0.3459192649461353,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11488724876061936,0.09958064418004216,0.25335091628187717,-0.08444506777701653,0.31421956529825523,54,7,61,1,log_other_mut_burden,False,58,0.051701792379801916,0.21039542568505948,0.8628310878918259,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09761827099567116,0.1071691995999214,0.36612887099995395,-0.1169041896053421,0.31214073159668443,54,7,61,1,log_other_mut_burden,False,58,-0.046080495342549675,0.17594347712040145,0.914684777397777,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11676432343536243,0.10767762220158744,0.2826798588607468,-0.09877585557674036,0.33230450244746523,54,7,61,1,log_other_mut_burden,False,58,-0.09964410304207642,0.03892697811629973,0.877125252431494,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0540880317133574,0.07651985403010486,0.4824901771318011,-0.20725916140965958,0.09908309798294476,54,7,61,1,log_other_mut_burden,False,58,0.11531465524892336,0.20668352131538922,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.059578785172293154,0.09391855250847375,0.5283359417501376,-0.12841962346953115,0.24757719381411744,54,7,61,1,log_other_mut_burden,False,58,-0.08157295748020588,0.040618935982626524,0.9450734236122966,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09848453366577764,0.08565640584580797,0.25496058510941944,-0.07297539154481633,0.26994445887637164,54,7,61,1,log_other_mut_burden,False,58,-0.05095966696856183,0.12736751666570034,0.8646722506638599,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07493399817361279,0.05441785545813187,0.17380053358710154,-0.033995174546618004,0.18386317089384357,54,7,61,1,log_other_mut_burden,False,58,0.014616644911245265,0.07718036876214707,0.7883592203510926,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008920607056973177,0.06285811892958672,0.8876377404710861,-0.11690358862486117,0.1347448027388075,54,7,61,1,log_other_mut_burden,False,58,-0.11904228192165774,-0.04611745482168128,0.9882859306472693,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03125106358632744,0.07605455295930066,0.6826576950513428,-0.12098866482115446,0.18349079199380935,54,7,61,1,log_other_mut_burden,False,58,-0.09130147363993829,0.008255647262380943,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01857343677273231,0.10864145763153464,0.8648495713511862,-0.23604294201679907,0.19889606847133443,54,7,61,1,log_other_mut_burden,False,58,-0.00024059104808759113,0.11791414321025905,0.9858092902621649,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06120781069845486,0.11889953362361613,0.6086588901670111,-0.1767954646126519,0.2992110860095616,54,7,61,1,log_other_mut_burden,False,58,-0.024572161054809468,0.06919635903122925,0.9540944451314641,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019192283610783067,0.06228570788058294,0.759085034891899,-0.1054861068661425,0.14387067408770865,54,7,61,1,log_other_mut_burden,False,58,0.00031809680962831575,0.08681426285938819,0.9671937410869814,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05186516978611819,0.11031134756967194,0.6399962021138852,-0.1689469833437162,0.2726773229159526,54,7,61,1,log_other_mut_burden,False,58,-0.047246031663398365,0.09312620197402185,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11171199012671551,0.07382424075736894,0.13565534602326018,-0.03606328335105721,0.25948726360448826,54,7,61,1,log_other_mut_burden,False,58,0.15076850022568497,0.2689566715418164,0.7473242853882033,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053771886066735046,0.08192581298632702,0.5141955637260516,-0.11022044619080854,0.21776421832427864,54,7,61,1,log_other_mut_burden,False,58,-0.03275603304711416,0.0792824330931696,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11927663560928882,0.08478828434682337,0.16483492546562892,-0.05044555561842533,0.28899882683700295,54,7,61,1,log_other_mut_burden,False,58,0.009390180285615514,0.14405092654024648,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03159303836237361,0.07020310752078386,0.6543711462366478,-0.10893374940330734,0.17211982612805454,54,7,61,1,log_other_mut_burden,False,58,0.07589755347334524,0.14572473341545406,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09292988191913942,0.06789918602951993,0.17638824282886767,-0.042985105915380545,0.2288448697536594,54,7,61,1,log_other_mut_burden,False,58,0.07497854843459512,0.18699652397349356,0.7917994815735138,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04042989904588025,0.07809652174502402,0.6066426175484422,-0.11589727398206291,0.19675707207382342,54,7,61,1,log_other_mut_burden,False,58,-0.006777260222511805,0.054826199083496695,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08528938265142305,0.1316113368118922,0.5195164930516841,-0.178159331356669,0.3487380966595151,54,7,61,1,log_other_mut_burden,False,58,-0.10408456877675329,0.10199013033648403,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.026459460983733734,0.057251251983127645,0.6456928270999829,-0.08814137110009747,0.14106029306756493,54,7,61,1,log_other_mut_burden,False,58,-0.002386759604981062,0.04870881042683889,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.018354132873831485,0.07161679685040506,0.7986395407924937,-0.12500246154010178,0.16171072728776473,54,7,61,1,log_other_mut_burden,False,58,-0.0523570861863179,0.06823509047834951,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05300543205233025,0.07445064237146148,0.4793473251971466,-0.09602372048846833,0.2020345845931288,54,7,61,1,log_other_mut_burden,False,58,-0.022794253783084327,0.05189064444899675,0.9384017168502401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03357932178953469,0.06016058713918129,0.5788824659892602,-0.08684517734340752,0.1540038209224769,54,7,61,1,log_other_mut_burden,False,58,0.0328679027441638,0.13590209126268593,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06624840309297754,0.06844567440319325,0.3371143794117173,-0.0707605000740064,0.20325730625996147,54,7,61,1,log_other_mut_burden,False,58,-0.07206675065089437,0.026211353595769593,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11885889780979482,0.06408432709935726,0.06872083348294787,-0.009419820204670928,0.24713761582426058,54,7,61,1,log_other_mut_burden,False,58,-0.007709412753199881,0.13771916255406438,0.6034358143668586,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06849639902459449,0.06388425443914406,0.2880734223825675,-0.05938183004782306,0.19637462809701206,54,7,61,1,log_other_mut_burden,False,58,0.002017554727816791,0.13628267634469793,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05355111761915724,0.05733034886025713,0.35413536979285964,-0.06120804406656535,0.16831027930487982,54,7,61,1,log_other_mut_burden,False,58,-0.10225116738453911,-0.05917004804322199,0.9094475823584263,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07710772936759401,0.07201638584197542,0.28874109680852394,-0.06704872931723761,0.22126418805242565,54,7,61,1,log_other_mut_burden,False,58,-0.010359255807130251,0.12109826089983196,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04845381386937048,0.044151704710541965,0.27698477351750933,-0.03992542540453893,0.13683305314327987,54,7,61,1,log_other_mut_burden,False,58,-0.053291108218641574,-0.0007281377679234924,0.8725380346331878,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0351679066668126,0.0807640329871087,0.6648591433525335,-0.12649887025356543,0.19683468358719064,54,7,61,1,log_other_mut_burden,False,58,-0.03988130781594247,0.08147069165491974,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07154297073242322,0.06742172593537163,0.2930311943666655,-0.06341627688365847,0.2065022183485049,54,7,61,1,log_other_mut_burden,False,58,0.10519177125466392,0.22507246895744545,0.8803348634474737,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16458253193637606,0.14165783237182153,0.2500627760824977,-0.11897642788841406,0.4481414917611662,54,7,61,1,log_other_mut_burden,False,58,-0.11410470957417544,0.127173741008495,0.8577585765822857,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.038951255121664294,0.08126340763048034,0.6335127051407156,-0.20161763899681817,0.12371512875348957,54,7,61,1,log_other_mut_burden,False,58,0.04003428866295896,0.12617683526049922,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13160197590296563,0.07790969415756495,0.0965582474018374,-0.024351221076640034,0.28755517288257126,54,7,61,1,log_other_mut_burden,False,58,0.016164006915609937,0.2343098857632056,0.673446463693037,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05238336511774952,0.0847531108942707,0.538948650586222,-0.11726841879501221,0.22203514903051125,54,7,61,1,log_other_mut_burden,False,58,-0.046264415216009824,0.009001539610933052,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08352847071167319,0.1295149768206174,0.5215136081488494,-0.1757239228488216,0.342780864272168,54,7,61,1,log_other_mut_burden,False,58,-0.10086351840552871,0.07914429698862001,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09692087217029842,0.07172812135205911,0.18187055121637685,-0.0466585624450095,0.24050030678560635,54,7,61,1,log_other_mut_burden,False,58,-0.021647415107500012,0.11300095481152128,0.8014130815101496,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08984651314875285,0.08326182359733877,0.28501739574534385,-0.07682013490785654,0.2565131612053622,54,7,61,1,log_other_mut_burden,False,58,-0.020365272128954174,0.15303492939094013,0.8771632762317894,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12620146541426597,0.10160169127814625,0.21919151875783,-0.07717641643592588,0.3295793472644578,54,7,61,1,log_other_mut_burden,False,58,0.07991799970794207,0.252049122532776,0.8337844604918982,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04865089998518483,0.07417921168276868,0.5145099985565897,-0.09983492500032379,0.19713672497069343,54,7,61,1,log_other_mut_burden,False,58,-0.002753586703479192,0.15035260148684662,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.020192702369766946,0.04682122123203193,0.6678690615328193,-0.0735301547994235,0.11391555953895739,54,7,61,1,log_other_mut_burden,False,58,0.2169592741558324,0.23920717347735346,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09543672440137539,0.07138202090850575,0.18644783051387515,-0.04744991490480134,0.23832336370755214,54,7,61,1,log_other_mut_burden,False,58,0.026432225728676893,0.14116834449144902,0.8085168201280608,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12558245576706215,0.10327009485375967,0.22888887609376804,-0.08113509869104552,0.3323000102251698,54,7,61,1,log_other_mut_burden,False,58,0.01604550482651289,0.21873172566488888,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05420145023047367,0.0662719850404673,0.41678234430241257,-0.07845634093404122,0.18685924139498858,54,7,61,1,log_other_mut_burden,False,58,0.007773139929919198,0.1488221818024715,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05995054562905808,0.06775858563409441,0.37993569075288447,-0.07568299993566088,0.19558409119377704,54,7,61,1,log_other_mut_burden,False,58,0.07205864028938368,0.13833267000155922,0.9192104581519039,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11664318012403908,0.06922589085640085,0.09736944598377797,-0.021927495958748308,0.25521385620682646,54,7,61,1,log_other_mut_burden,False,58,0.057540302835348514,0.189248125396736,0.6768114380203412,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03929875062424969,0.06310490020233721,0.5358879811205122,-0.08701943144600892,0.16561693269450828,54,7,61,1,log_other_mut_burden,False,58,-0.037792481502171675,0.04175965347796584,0.9471273828544232,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05249600558119101,0.06420742280611055,0.41693157964293903,-0.07602911526170604,0.18102112642408807,54,7,61,1,log_other_mut_burden,False,58,-0.013759366115716497,0.05730338913437933,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07125354161288448,0.08140936513398887,0.38504816819908116,-0.09170500794898458,0.23421209117475356,54,7,61,1,log_other_mut_burden,False,58,-0.14900765713650493,-0.07598586583830837,0.9192918506885728,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06580170075483228,0.061106086884844465,0.28600885332541187,-0.056515421750258754,0.18811882325992332,54,7,61,1,log_other_mut_burden,False,58,0.0006443629967478015,0.10357817184814515,0.8775950049080478,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08346266569841215,0.06845829273968133,0.22771278140399304,-0.05357149581334081,0.22049682721016511,54,7,61,1,log_other_mut_burden,False,58,-0.06549396203593313,0.012392799546706579,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07375107790277538,0.06634307021717252,0.27087032737835487,-0.059049005702813906,0.20655116150836467,54,7,61,1,log_other_mut_burden,False,58,0.023496334198277482,0.0912042911755996,0.870012817074135,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07066598893037758,0.06879293585573389,0.3085784607319296,-0.06703803355772663,0.20837001141848177,54,7,61,1,log_other_mut_burden,False,58,-0.10422552940461101,-0.02621984745796436,0.8969323713769235,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02694155564501114,0.04121883265473426,0.5159381139357483,-0.055566902356026994,0.10945001364604928,54,7,61,1,log_other_mut_burden,False,58,-0.07718076679035456,-0.03885878115126127,0.9438759903131516,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07536200204799644,0.04693434114646,0.11377357538155401,-0.018587289231709686,0.16931129332770256,54,7,61,1,log_other_mut_burden,False,58,-0.08404789597598183,-0.01862797777822873,0.7095033877612622,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11065195363075134,0.07029857347427984,0.1209204425975696,-0.03006593000318311,0.25136983726468576,54,7,61,1,log_other_mut_burden,False,58,0.02677384833038825,0.1578985590326694,0.7228579124835106,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04903307320911243,0.0708439516696428,0.491618715034422,-0.09277650349395161,0.19084264991217648,54,7,61,1,log_other_mut_burden,False,58,-0.0221915340277032,0.09341440623001795,0.9421219642690486,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09208855558677129,0.12996305047026172,0.4814266180658563,-0.16806075483240127,0.35223786600594387,54,7,61,1,log_other_mut_burden,False,58,0.026095582419863983,0.23181653539526456,0.9396519533333579,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06780493892920739,0.08046832054889769,0.4028974080807559,-0.22887978309173923,0.09326990523332446,54,7,61,1,log_other_mut_burden,False,58,0.04100481421619499,0.08070240380633753,0.923447045283853,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0710392931090614,0.04902576783761253,0.15271751511152765,-0.02709644354513277,0.16917502976325557,54,7,61,1,log_other_mut_burden,False,58,0.0173751569285507,0.11108129107311138,0.7692078902000675,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04076657371883508,0.08125976587323683,0.617790213894846,-0.12189252038717144,0.2034256678248416,54,7,61,1,log_other_mut_burden,False,58,0.018558867260391906,0.1323290685717166,0.9570684461157861,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07924801278525606,0.07294984771239287,0.28182489579863157,-0.06677697284637307,0.2252729984168852,54,7,61,1,log_other_mut_burden,False,58,0.024862183093623532,0.15122196658572676,0.8770089248428307,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08559283728920515,0.07286413757225511,0.24491876620014977,-0.060260580856341686,0.231446255434752,54,7,61,1,log_other_mut_burden,False,58,-0.024034055601079688,0.1409320282999132,0.8534526629046483,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1038979209576137,0.07109879016819336,0.1493251001406431,-0.03842177042363233,0.24621761233885975,54,7,61,1,log_other_mut_burden,False,58,-0.06967465507340154,0.08643521652821937,0.7662201971017615,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08442489087313533,0.0833372998012432,0.31524362647928533,-0.08239283922046646,0.2512426209667371,54,7,61,1,log_other_mut_burden,False,58,-0.03241432966394364,0.12459813732414064,0.9025176929330414,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025859997384115943,0.07441243166433634,0.7294567772411225,-0.12309266811614865,0.17481266288438052,54,7,61,1,log_other_mut_burden,False,58,-0.02693379522763659,0.05265241871650123,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03639369794403025,0.10451062611656904,0.7289285199842247,-0.1728070496324717,0.2455944455205322,54,7,61,1,log_other_mut_burden,False,58,0.01795790733571334,0.17085143434522745,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.04988169795570766,0.10854542870368791,0.6475594938252855,-0.2671589804159199,0.16739558450450456,54,7,61,1,log_other_mut_burden,False,58,0.14492700298924094,0.20465440877365287,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.013960243653393722,0.08726029631090636,0.8734496158483338,-0.18863070445062896,0.16071021714384154,54,7,61,1,log_other_mut_burden,False,58,-0.12303928284885558,-0.05108860032521902,0.9858799847884159,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03748211619003665,0.10616490521739848,0.7253266913003757,-0.17503003078625162,0.24999426316632495,54,7,61,1,log_other_mut_burden,False,58,0.05913985576711827,0.17225417586040587,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012752168764431103,0.05014258845420846,0.8001493017809636,-0.08761912724465698,0.1131234647735192,54,7,61,1,log_other_mut_burden,False,58,0.04368819001243537,0.12707947798829158,0.9740375132149399,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025861558142878105,0.06642898462781334,0.698471599637825,-0.10711050184063095,0.15883361812638716,54,7,61,1,log_other_mut_burden,False,58,0.006894745070830686,0.08867882802068397,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0639442123097749,0.07423550833790794,0.3925816572712765,-0.08465430267462484,0.21254272729417464,54,7,61,1,log_other_mut_burden,False,58,-0.10844212141305386,-0.018812834133107182,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.024634537019364675,0.05035998362715467,0.6265669698704946,-0.12544099674710799,0.07617192270837864,54,7,61,1,log_other_mut_burden,False,58,-0.07770902558345633,-0.05347557841665635,0.9600602055593583,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05152953121842508,0.0825081913075794,0.5347232389567758,-0.11362855790715656,0.2166876203440067,54,7,61,1,log_other_mut_burden,False,58,-0.043748490924990946,0.06359578535446016,0.9468590670943479,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.025642394478638045,0.07796815712934987,0.7434287906233845,-0.1817126178110407,0.13042782885376458,54,7,61,1,log_other_mut_burden,False,58,0.016729431695502523,0.1410640491292742,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07641983503494588,0.06315035583647613,0.2311397234787517,-0.04998933637292151,0.20282900644281326,54,7,61,1,log_other_mut_burden,False,58,-0.11827647722942673,-0.04633472177329832,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05895012047713728,0.07011612958849342,0.40394092902191736,-0.08140256204074307,0.19930280299501762,54,7,61,1,log_other_mut_burden,False,58,0.038714093652950636,0.11700989713120988,0.9235345118679857,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07284467672391771,0.06162235683429253,0.24198410539796517,-0.050505872365522286,0.19619522581335772,54,7,61,1,log_other_mut_burden,False,58,0.04696396234622537,0.18958378229252415,0.8491564414671808,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06460732229562195,0.062098636565961964,0.30247249506081014,-0.059696604260044764,0.18891124885128868,54,7,61,1,log_other_mut_burden,False,58,-0.041936505471775604,0.06383988897558777,0.8904632102898862,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053014197857707654,0.05455099844403384,0.33517163334946554,-0.05618148950529443,0.16220988522070973,54,7,61,1,log_other_mut_burden,False,58,0.10227748517318486,0.21098072370259383,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.067218019005643,0.04361041776524593,0.12867533507852297,-0.020077716725927758,0.15451375473721377,54,7,61,1,log_other_mut_burden,False,58,-0.015243650136295535,0.0675650120854316,0.7302718857033121,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07703268506020958,0.06165996025769169,0.21656843438321305,-0.04639313545931224,0.20045850557973138,54,7,61,1,log_other_mut_burden,False,58,0.022273849164521128,0.14430658957086084,0.8295752524063543,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1100148715105687,0.11737667561510966,0.3525008929261214,-0.12494007229904004,0.34496981532017745,54,7,61,1,log_other_mut_burden,False,58,-0.014140715434113472,0.2093630059703707,0.9090812501778921,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.004190997933976906,0.0961737193460467,0.9653909700871446,-0.18832161759628166,0.19670361346423546,54,7,61,1,log_other_mut_burden,False,58,-0.03474672309393812,0.06355024096168639,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07534293012421761,0.06401350655754627,0.24400917589340318,-0.052794025173468456,0.20347988542190368,54,7,61,1,log_other_mut_burden,False,58,0.01358037302716174,0.07967225512738665,0.8528284808184983,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06805152531150982,0.11803506132264839,0.5664834271993207,-0.16822132068019052,0.30432437130321016,54,7,61,1,log_other_mut_burden,False,58,-0.09510999471436603,0.09157393336808663,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07879688888415348,0.09623134561204776,0.41623651488444,-0.11383107815030541,0.2714248559186124,54,7,61,1,log_other_mut_burden,False,58,0.006298697107206945,0.15648531940079433,0.9275420473817595,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13279669915129286,0.09576954248985314,0.17086218314197926,-0.05890686849923624,0.324500266801822,54,7,61,1,log_other_mut_burden,False,58,-0.07252089288346822,0.08728151138944742,0.7844441930486012,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08061261325704934,0.08819088457460424,0.36446462257329737,-0.09592062233817032,0.257145848852269,54,7,61,1,log_other_mut_burden,False,58,0.09862892024071114,0.2732037520390696,0.9137080279957605,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09374894358424042,0.12080042457342154,0.44086401045187373,-0.14805937837654526,0.3355572655450261,54,7,61,1,log_other_mut_burden,False,58,-0.2863917966566272,-0.1256578275075809,0.9320838159679753,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016002376434938147,0.0876794160835865,0.8558188915096459,-0.15950704373922192,0.19151179660909823,54,7,61,1,log_other_mut_burden,False,58,-0.10921304476750812,-0.007882286981914765,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00470144504536028,0.0785113417948309,0.9524551810877102,-0.16185897061977586,0.15245608052905532,54,7,61,1,log_other_mut_burden,False,58,0.045685603821441816,0.1746586683545013,0.9940904623189993,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.012054617344925054,0.08126294954378775,0.8825882923599064,-0.1747200842599371,0.150610849570087,54,7,61,1,log_other_mut_burden,False,58,-0.027243466227042483,0.08880132338566413,0.9870366109823806,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048974085461466324,0.09403942571830975,0.6045009097814802,-0.13926627719785145,0.23721444812078407,54,7,61,1,log_other_mut_burden,False,58,-0.12169428174411745,0.01099334426566212,0.9533164021566217,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.021290259492318483,0.12387907846928789,0.8641433042091284,-0.22668065779945468,0.26926117678409167,54,7,61,1,log_other_mut_burden,False,58,0.7753120358289385,0.7887152312476191,0.9854445582989166,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0033608092905978164,0.06926406394116841,0.9614671818666597,-0.13528627852339253,0.14200789710458817,54,7,61,1,log_other_mut_burden,False,58,0.09389825981235465,0.200395240771694,0.9962057403241632,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02118465042664201,0.06439059215350276,0.7433390450381259,-0.10770712370148948,0.1500764245547735,54,7,61,1,log_other_mut_burden,False,58,0.09668170252353986,0.206751146792258,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04526191696968567,0.0901808529706195,0.6176367629918111,-0.13525467315673417,0.22577850709610553,54,7,61,1,log_other_mut_burden,False,58,-0.12633882631604834,-0.019207977169086447,0.9570174945596325,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025270326213428035,0.058752365537530576,0.6687052846606314,-0.09233531111793891,0.14287596354479498,54,7,61,1,log_other_mut_burden,False,58,0.023381934208181337,0.1271580570735574,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04161558621858907,0.09082925141852012,0.6485396258881763,-0.1401989144176861,0.22343008685486423,54,7,61,1,log_other_mut_burden,False,58,-0.17264688621396285,-0.05728746458894603,0.9604336667767839,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0235505657640319,0.10121007447831465,0.816821362400216,-0.17904340989085205,0.22614454141891582,54,7,61,1,log_other_mut_burden,False,58,-0.1276457462838004,-0.024479294558014737,0.9781640470283297,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09872508528045788,0.06683712813590942,0.1450585477454592,-0.035063962699247456,0.23251413326016324,54,7,61,1,log_other_mut_burden,False,58,0.0017336720060986894,0.14062722631832197,0.7643196110722902,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08468054153133453,0.050331175996648075,0.09785498637638324,-0.016068253458746934,0.185429336521416,54,7,61,1,log_other_mut_burden,False,58,-0.06534629686974158,0.00888281722120701,0.6772213442508546,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10143645592863194,0.09358466969092738,0.2828942285725534,-0.0858936136396541,0.288766525496918,54,7,61,1,log_other_mut_burden,False,58,0.02023810866551015,0.1693569386935861,0.877125252431494,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.008597309041314309,0.07282549407530482,0.9064331138814684,-0.13717875574073862,0.15437337382336724,54,7,61,1,log_other_mut_burden,False,58,-0.07281355722275512,-0.023588643875405428,0.9887719540319797,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02476820007329137,0.13656043209315263,0.8567081650663577,-0.2485872044900004,0.29812360463658316,54,7,61,1,log_other_mut_burden,False,58,-0.028604967608610428,0.14693235435137422,0.9836246458712524,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03459365450947201,0.1006255286291527,0.7322503888077077,-0.1668302254988599,0.23601753451780394,54,7,61,1,log_other_mut_burden,False,58,-0.08556389006455972,0.010033230564561265,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.009696987108827868,0.09806312459300776,0.9215704321637037,-0.1865976839389084,0.20599165815656412,54,7,61,1,log_other_mut_burden,False,58,-0.07366268663701184,0.022402171255285024,0.9905790237664834,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01097177330821255,0.10286687171054128,0.9154268436303741,-0.21688218895052797,0.19493864233410285,54,7,61,1,log_other_mut_burden,False,58,-0.009243769540259376,0.08173706825505946,0.9895309118568834,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012370169590598537,0.06263026379798822,0.8441182023302023,-0.11299792449046288,0.13773826367165995,54,7,61,1,log_other_mut_burden,False,58,0.059271765337731916,0.13260744583622236,0.9824089645441008,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13828604314816859,0.11046097877606124,0.21563169579967606,-0.082825629383669,0.35939771568000617,54,7,61,1,log_other_mut_burden,False,58,-0.24158606250685805,-0.10519552281893396,0.8295752524063543,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10539223779586808,0.14177519089172644,0.4602549423947737,-0.1784016406301291,0.3891861162218653,54,7,61,1,log_other_mut_burden,False,58,-0.1282512523864633,0.07574691549270214,0.9366557334939974,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07616254317662008,0.048374601438598244,0.12082702157752404,-0.020669742311579295,0.17299482866481947,54,7,61,1,log_other_mut_burden,False,58,-0.039445531460767964,0.04935907198263368,0.7228579124835106,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.044971872422646095,0.06375163513768246,0.48337061660535485,-0.08264089027530065,0.17258463512059286,54,7,61,1,log_other_mut_burden,False,58,0.10278089012036146,0.1620547946201936,0.9400644974323602,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043978782637642634,0.044197561974528295,0.3238452837152024,-0.04449224992336328,0.13244981519864854,54,7,61,1,log_other_mut_burden,False,58,-0.10043781068081777,-0.06819183387600894,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10897865195602871,0.08807886705512163,0.22096730454731187,-0.06733035621191205,0.28528766012396944,54,7,61,1,log_other_mut_burden,False,58,0.12367726687885805,0.22673379621913364,0.8355377918591873,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01981564805742377,0.04843147365906735,0.6839379255126979,-0.07713047954885079,0.11676177566369832,54,7,61,1,log_other_mut_burden,False,58,-0.2087945468382897,-0.20957207368326863,0.9621831471002781,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06713059483542756,0.05529129880997725,0.229620225299835,-0.04354696471360256,0.17780815438445768,54,7,61,1,log_other_mut_burden,False,58,0.06587294340781727,0.1444321761958936,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03175987847157472,0.04287059949631821,0.46178462004262566,-0.05405495009599338,0.11757470703914283,54,7,61,1,log_other_mut_burden,False,58,-0.058093059212777035,-0.025337736159670634,0.9370609591482926,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07088760064978349,0.07509406740254747,0.34909364050427083,-0.07942950702547659,0.22120470832504358,54,7,61,1,log_other_mut_burden,False,58,-0.05213950450257881,0.05501684362700251,0.9086977961712401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.047582609365994406,0.0552474215575242,0.3926393951177216,-0.0630071203196442,0.158172339051633,54,7,61,1,log_other_mut_burden,False,58,-0.028160102611073556,0.0159906698762273,0.9200851777021611,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.042511273209197085,0.07577810642472707,0.5769607631890046,-0.1091750873365975,0.1941976337549917,54,7,61,1,log_other_mut_burden,False,58,-0.017516383866778645,0.061839524207551434,0.9525219182038099,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05417112360644294,0.07040649567973191,0.44477498359610357,-0.08676278979307242,0.1951050370059583,54,7,61,1,log_other_mut_burden,False,58,0.05249734096634633,0.08461371288712809,0.9330352189956562,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07123062430406162,0.05852163473140568,0.22846990954441532,-0.04591315513855421,0.18837440374667744,54,7,61,1,log_other_mut_burden,False,58,0.11316004759200238,0.18914223665391622,0.842940686827401,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04576226755093307,0.04274617122806046,0.2888029737667622,-0.039803490776541564,0.1313280258784077,54,7,61,1,log_other_mut_burden,False,58,-0.1724248272129833,-0.13653509376195244,0.8780447660402404,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10977862215713718,0.06752502624616549,0.10942543104169235,-0.025387403497178218,0.2449446478114526,54,7,61,1,log_other_mut_burden,False,58,0.047833126112102255,0.1482096619436805,0.6985162532376802,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05931623385788294,0.061115732301980405,0.335799670329305,-0.06302019604733099,0.18165266376309686,54,7,61,1,log_other_mut_burden,False,58,-0.006748384771956867,0.05161637135669237,0.9034998483867911,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08225334190426785,0.07469882801344074,0.27538763594740673,-0.06727260817539442,0.2317792919839301,54,7,61,1,log_other_mut_burden,False,58,-0.0038108905938864096,0.09449047903553731,0.8716406527156833,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.040426272768965904,0.06606782040762678,0.543001477905904,-0.09182283848034803,0.17267538401827984,54,7,61,1,log_other_mut_burden,False,58,0.015483248182148064,0.048010176942355834,0.9485922053772787,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0993753253641086,0.07075387788827212,0.1654965320400703,-0.042253949075922684,0.2410045998041399,54,7,61,1,log_other_mut_burden,False,58,-0.013029100711271105,0.10596532012204747,0.7824698350312412,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08546036204531342,0.05694091257091212,0.13881626092385702,-0.028519258211066614,0.19943998230169346,54,7,61,1,log_other_mut_burden,False,58,-0.08144025640971021,0.02175250827320352,0.7542255162310588,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03250058403888535,0.09063822317968824,0.721215116088481,-0.21393270010952525,0.14893153203175458,54,7,61,1,log_other_mut_burden,False,58,0.36329556782354977,0.47907627052048013,0.963305304214035,1.0 +ENTREZ:324,ENTREZ:9699,APC,RIMS2,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18821319956975263,0.0989897940013474,0.062229200472049745,-0.009936401834679615,0.38636280097418485,54,7,61,1,log_other_mut_burden,False,58,-0.16352672896862708,-0.08564162639985629,0.5802376411176683,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GLI1 UP.V1 DN,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.00737918881646063,0.16736361185227033,0.964928663658662,-0.3398264438807953,0.3250680662478741,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11308336260379,-0.04055766985064389,0.9962057403241632,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GLI1 UP.V1 UP,24,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.003432608914513191,0.20518352070832302,0.9866890719156602,-0.40413924908367893,0.4110044669127053,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1484956901019598,-0.059736461349169566,0.9990141708527136,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F1 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1284908301413062,0.1419703892609042,0.36782688843232325,-0.15351590769047208,0.41049756797308445,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0466234156256688,0.1065215883766721,0.9150244079451123,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F1 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.05744284976082608,0.2982889383060193,0.847721319012073,-0.6499571822276872,0.5350714827060351,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.286659741730162,-0.22396970287038065,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EGFR UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15719274599061922,0.19471901955601917,0.42161030546553435,-0.22959266598624922,0.5439781579674876,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.17357108073012156,0.03004485843818109,0.9282753503874777,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EGFR UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1000272336368233,0.13817994988312543,0.4709894650087785,-0.17445026200972652,0.37450472928337314,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.07325300754365996,0.16946922008114568,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ERB2 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01513256816264033,0.2183924185583994,0.9449102467311248,-0.4186771427599927,0.4489422790852733,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.216263113362041,-0.12331370585335141,0.993077588787628,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ERB2 UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10721639397240265,0.12871632564196028,0.4070444666237517,-0.14846277468349453,0.3628955626282998,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.009308329567424436,0.11260132153103734,0.9239663408808872,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP EARLY.V1 DN,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12031468326251801,0.151542896416528,0.42930076675401396,-0.18070666409370015,0.42133603061873615,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.133378485613195,0.026000720257170328,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.005921288881362646,0.29871941752801257,0.9842285721990007,-0.5874481376775178,0.5992907154402431,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.2950432279441154,-0.17873354705287228,0.998871063691614,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP LATE.V1 DN,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14212304224936476,0.17161838886483438,0.40976120044235165,-0.19877580466987269,0.4830218891686022,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05261915916678836,0.14631710986793445,0.9258730384511746,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,GCNP SHH UP LATE.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.03331994185802985,0.3206985835646025,0.9174789348757214,-0.6703482817051661,0.6037083979891064,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.2909747429937829,-0.22456546944913286,0.9900690300494123,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAPA EARLY UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12470708860289448,0.1797850660436228,0.4896714088818491,-0.23241385929180014,0.4818280364975891,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09421683586917856,0.09486538950808887,0.9416210377190208,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAPA EARLY UP.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15470119802493962,0.13887686555285444,0.26823634939497215,-0.12116063498651627,0.4305630310363955,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09670347985377323,0.10428231310550598,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HINATA NFKB IMMU INF,16,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14968813526708405,0.29724011745453055,0.6157641130191734,-0.440742843421302,0.74011911395547,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.28859190853243416,0.3787453404463478,0.9561721723743585,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HINATA NFKB MATRIX,10,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11127111773995374,0.14739740628377698,0.45225499680035486,-0.4040579582026075,0.1815157227227,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.25371687095429285,0.05584618953417995,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 KE .V1 DN,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11807094044436671,0.14531908278164468,0.41862848247876894,-0.17058756569416011,0.40672944658289356,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12407550049934477,0.026400335979271616,0.9275420473817595,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 KE .V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.045917547795504096,0.18324833083210518,0.802707182057484,-0.31808275015473436,0.4099178457457426,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13858336765953233,-0.021805823807532786,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09056407720703728,0.1636848935407302,0.58142639580418,-0.23457585584571267,0.41570401025978726,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.15792215914318952,-0.00857490189826023,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CYCLIN D1 UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.052647894768275916,0.1590450912791772,0.7413866677268122,-0.26327564107110535,0.3685714306076572,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09451025280251926,0.017794424242059133,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR EARLY UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.24933160162014448,0.23146565582630252,0.28424443312759806,-0.21044648914574535,0.7091096923860343,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14829960064964817,0.17447864435141758,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR EARLY UP.V1 UP,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0613805803661414,0.15418780354027664,0.6914964583324968,-0.36765571080853293,0.2448945500762501,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1783467432752545,-0.15519542822429316,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR LATE UP.V1 DN,149,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09887151049980256,0.16407853961445504,0.5482825238714857,-0.22705035212072103,0.42479337312032617,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09525948277930697,0.024486914559211433,0.9485922053772787,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CSR LATE UP.V1 UP,156,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.24628063155806784,0.2895682558870112,0.39727406017611255,-0.8214723996968711,0.3289111365807355,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21766364926518628,-0.381807377733133,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP MTOR DN.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.030033278898010843,0.20119878573669675,0.8816695875848177,-0.3696233925861299,0.4296899503821516,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14035388325900436,-0.05353918751921094,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP MTOR DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1879062181413354,0.09133763437830873,0.0425219390673132,0.0064752278736224245,0.3693372084090484,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.04115660645703404,0.2540853680556606,0.49492544327907945,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08614106406770519,0.16135477879856042,0.5947392452743223,-0.2343703822940247,0.40665251042943507,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06598610304074316,0.05120649511288593,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,AKT UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18100937462407682,0.10557343383667431,0.08983437855489859,-0.028699282462618464,0.39071803171077213,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.11021243596932373,0.3002003427531804,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16029544613313187,0.16132290647839795,0.3230373198507539,-0.16015268977996897,0.4807435820462327,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08221076348717765,0.1278491861090249,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.V1 UP,155,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0353945874046047,0.2024596156729047,0.8616071341490104,-0.36676656786042666,0.4375557426696361,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07485051707019225,-0.00347985492127703,0.9841643751662926,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PIGF UP.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14702002200601957,0.13902180565215128,0.29306808474251933,-0.1291297167074387,0.42316976071947787,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06393962673426,0.13475630856360293,0.8803348634474737,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PIGF UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07450409443770878,0.2144983016067434,0.7291370619203335,-0.35157043153552053,0.5005786204109381,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.26425367844578695,-0.10178258351907346,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,VEGF A UP.V1 DN,186,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.13835704507634006,0.25148396539767465,0.5835558345071077,-0.637899048644883,0.36118495849220295,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.25653267173846855,-0.3103781055002548,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,VEGF A UP.V1 UP,185,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14593463165124243,0.14578777701646523,0.3194776360345202,-0.14365487800773968,0.43552414131022454,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10791566348576402,0.08332973950873859,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT GDS748 DN,42,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025837183514273165,0.29923804432272466,0.9313832622844549,-0.5685624314612927,0.6202367984898391,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.22697057022647119,-0.10698058438015949,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT GDS748 UP,46,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10381824539966258,0.10592221782079614,0.3296172971303173,-0.10658322822491939,0.31421971902424456,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07949686703666684,0.044746223661120535,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT.100 UP.V1 DN,28,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03378790198815244,0.16822491941305173,0.8412644367258243,-0.30037023473784646,0.3679460387141514,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09134908080961503,-0.015484470187499405,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT.100 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.048648655341849534,0.1081682689944779,0.6539603593681736,-0.16621432302178904,0.26351163370548814,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.021537500556118517,0.03060309778624305,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 S UP.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13857394128213654,0.10994768644497935,0.21076092099778934,-0.0798236312533519,0.356971513817625,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05481273814087988,0.10294960668915891,0.8252886794984905,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 S UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07368775253617635,0.11826847219101998,0.5348068410331639,-0.16123803871205927,0.30861354378441197,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.034353101183929674,0.0588973759027556,0.9468590670943479,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11777010053343023,0.11984629451641723,0.32837228938504726,-0.12028984093570616,0.3558300420025666,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07294438375126576,0.06710181048029638,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATF2 UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04828956877565617,0.13605289736274395,0.7234615833311103,-0.22196279833815935,0.31854193588947166,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08985133918360075,-0.0019768918599740947,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,WNT UP.V1 DN,162,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0662013375177636,0.13602280565508607,0.6276461180541223,-0.2039912561154229,0.33639393115095007,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08673937585615742,0.009169338757333795,0.9600602055593583,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,WNT UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12235679700698956,0.14534439005300942,0.40208416713658945,-0.1663519789172169,0.41106557293119605,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.036584899342967186,0.12739015725191585,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATM DN.V1 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16523231148655196,0.1246987301350891,0.18847140657253753,-0.08246639723880142,0.4129310202119053,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.044919212481905745,0.141153074549729,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ATM DN.V1 UP,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11756218968809587,0.10561609896720368,0.2685934676611167,-0.09223121643917326,0.327355595815365,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.023942718538748714,0.11604704535295036,0.870012817074135,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V2 DN,140,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09469262088654727,0.1447793731924638,0.5147305453743308,-0.19289381845401005,0.3822790602271046,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11297009014152211,0.02508885765685055,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V2 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1184048690767596,0.08335597500614604,0.1588874732514451,-0.04717153535973817,0.28398127351325736,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.008425265628604994,0.11900976291002277,0.7804909419375794,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RELA DN.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1350193945110344,0.08760625477404221,0.12673670391995323,-0.03899966855629999,0.3090384575783688,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.00355237719053289,0.13002315919506757,0.7263564310373228,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RELA DN.V1 UP,142,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10677773681371078,0.07597711083498848,0.1633091779413933,-0.044141460407641525,0.2576969340350631,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05018806875731254,0.09534268478677461,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V1 DN,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05434380608817378,0.07223438287133306,0.45379666335510327,-0.0891409218109697,0.19782853398731726,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13016251655063887,-0.05463467109416431,0.933731420853472,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,P53 DN.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06342271470950572,0.0926822570332084,0.4955231257901086,-0.12067920328121365,0.2475246327002251,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.11659566452477199,0.1689357032670302,0.9425014779477888,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT BILD ET AL DN,43,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10963527877619522,0.20416542589651013,0.5925834326524664,-0.29591425894677964,0.5151848164991701,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12892728705867454,0.04256908089777132,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BCAT BILD ET AL UP,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05719902846401917,0.18299776918749425,0.7553249506428206,-0.30630355955959054,0.42070161648762894,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05128952845406843,0.05255837695732044,0.9654221498691481,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F3 UP.V1 DN,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2035597715936298,0.17098414930621503,0.23693909162684745,-0.1360792363559376,0.5431987795431972,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.022963703822252234,0.21253162711278067,0.845523093424569,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,E2F3 UP.V1 UP,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10163495517171037,0.2853292466137511,0.7225135192012975,-0.4651365417893204,0.6684064521327412,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.20100556587114518,-0.01770816854315308,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MYC UP.V1 DN,148,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2140960573090394,0.16083484540436102,0.18646350871806314,-0.10538260523663345,0.5335747198547123,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.03768636692757805,0.2660084557051586,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MYC UP.V1 UP,159,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.14697972388421315,0.247726743624062,0.5544428964833124,-0.6390584679575677,0.34509902018914146,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.278006675858959,-0.3034543645851871,0.9491210479105492,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SRC UP.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07734348882151285,0.20081894070893072,0.7010321329144944,-0.321558667177254,0.47624564482027965,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09863966213177615,0.024188366313326846,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SRC UP.V1 UP,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14449731471322422,0.1629152800194782,0.3774452131567495,-0.17911387562317907,0.46810850504962753,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14323185181707845,0.06654860670694066,0.9170591775765864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SNF5 DN.V1 DN,150,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1634379148576204,0.08801853684645161,0.06656645838821185,-0.01140009589952437,0.33827592561476516,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.06188681393072382,0.21434022517596105,0.5974084401217474,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SNF5 DN.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02567270355208574,0.19269008932863677,0.8943031994937851,-0.35708248777320095,0.4084278948773724,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16700710112612985,-0.09425464171247303,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAMP UP.V1 DN,190,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.022910495925478582,0.12484795935582262,0.8548083586581957,-0.22508463831471154,0.2709056301656687,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16309116090485953,-0.09292095792068829,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAMP UP.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05370683721817818,0.26483155335766595,0.8397470545023475,-0.4723485101406846,0.5797621845770409,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.24613092081828775,-0.10335514371290033,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LTE2 UP.V1 DN,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08942499787452622,0.12441022580319704,0.474111131328111,-0.15770063243700594,0.3365506281860584,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05266408345213855,0.055113728082508376,0.937664825139976,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LTE2 UP.V1 UP,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012490662820656875,0.16192189917187444,0.9386814894855922,-0.30914729849442935,0.33412862413574307,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11877723805410775,-0.06360563931266215,0.992787535469879,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEK UP.V1 DN,168,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11490922603279596,0.18102095650295233,0.5271620150299534,-0.24466666643567475,0.4744851185012667,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.15027339360798878,0.0044133340713737425,0.9448126253726593,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEK UP.V1 UP,183,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1001161307156962,0.11456622241182045,0.38448869434596067,-0.12745559615118612,0.3276878575825785,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.07022320944942301,0.1823910306213624,0.9192918506885728,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAF UP.V1 DN,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16782857529300949,0.11985811512459787,0.16484566368796855,-0.07025484636216828,0.40591199694818725,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0904496812535294,0.09736898348591198,0.7824698350312412,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RAF UP.V1 UP,184,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03402404641740362,0.12036752281792609,0.7780733103351494,-0.2050712510420864,0.2731193438768936,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.0016988969890385304,0.04781388040434373,0.9700679690002965,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC1 BMI UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1899100744544331,0.0925364144496797,0.04301554935933143,0.006097854839776512,0.37372229406908963,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07527594251562993,0.15076814847603998,0.4970268279685195,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC1 BMI UP.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1788998747015776,0.15043409214601797,0.23744525717745849,-0.11991896918297762,0.4777187185861328,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0780341041947389,0.1421472764152218,0.8459452857747916,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EDD UP.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16518437652399937,0.09503167108454383,0.08555746513279701,-0.023584363864562807,0.35395311691256154,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09487592049962393,0.11002937556401068,0.6528607274170573,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EDD UP.V1 UP,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.04032261566445618,0.3039636018187761,0.8947582823431984,-0.5634637387631579,0.6441089700920702,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.17829660140076536,-0.033583805705801904,0.9882859306472693,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EZH2 UP.V1 DN,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09364011580726468,0.06253753517370024,0.13776479979768008,-0.030583015355424195,0.21786324696995357,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.023475060923015285,0.07646751640951621,0.7510830912046598,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 EZH2 UP.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.034508623003936936,0.28822161416331094,0.9049613846509037,-0.5380082067797213,0.6070254527875952,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1974085649678589,-0.08309621063939263,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 SUZ12 UP.V1 DN,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1535346387406588,0.11728768020847676,0.19381569249529046,-0.07944292972021602,0.3865122072015337,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04759200495839872,0.13216288267030962,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PRC2 SUZ12 UP.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10996401561695199,0.1486649597291591,0.46140007913244907,-0.1853406640516134,0.40526869528551734,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11943413315250538,0.03859898164191428,0.936984237335683,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JNK DN.V1 DN,173,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11153714642305668,0.1627420129888729,0.4948578918328399,-0.2117298702421383,0.43480416308825165,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.15407951429012787,0.007616728710239681,0.9421219642690486,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JNK DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0898603788382793,0.08941579391619293,0.3175751092601726,-0.08775311144104952,0.2674738691176081,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1288215103308103,-0.002994832221506103,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BRCA1 DN.V1 DN,122,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11036112552682291,0.1557302372886481,0.4803416771397516,-0.19897786007553792,0.41970011112918376,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12295134075314043,0.0583903310819068,0.938972145291407,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BRCA1 DN.V1 UP,119,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14313428256654803,0.10191504836551175,0.16358984109475636,-0.05930744119817297,0.34557600633126906,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07347347374695315,0.08231904738599534,0.7815260814768127,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CTIP DN.V1 DN,118,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20649643738314227,0.11941713165471107,0.08716377344175613,-0.0307110247819761,0.4437038995482606,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.033444756737608036,0.19696373104463066,0.6570209000268399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CTIP DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11545982945119274,0.08053744305287065,0.15510874185641568,-0.044517907504319915,0.27543756640670536,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12068755444795914,0.01835194991524969,0.7738863562892694,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PKCA DN.V1 DN,154,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1365870944324853,0.14229362065933523,0.33965103375640826,-0.1460617028647272,0.4192358917296978,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06891968912757825,0.10573036110058684,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PKCA DN.V1 UP,161,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20928360099146884,0.1739457044589431,0.23203728113605712,-0.13623817245502837,0.5548053744379661,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05377375276635947,0.18411814515832253,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.N4.V1 DN,153,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16362517268608812,0.20847099957834447,0.43456123983124006,-0.25047685823514854,0.5777272036073248,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.29486790729991363,-0.058298182352380525,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MTOR UP.N4.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.0733086466944016,0.16817164617482022,0.6639303048783682,-0.4073609626770356,0.26074366928823234,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14861409597896194,-0.14705959695349402,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V2 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09066822267555158,0.19451314266825612,0.6422370006136304,-0.29570824015484154,0.4770446855059447,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13569531302616294,0.014935321216818325,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V2 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11220878935568655,0.08361737016819377,0.1829569693460619,-0.053886844458978386,0.2783044231703515,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.020226605638099002,0.1369133708729751,0.801939493467167,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,DCA UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13539451090428006,0.19287178621643122,0.48447559344141167,-0.24772159896795048,0.5185106207765107,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14551603159560564,0.06162434528424039,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,DCA UP.V1 UP,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20407108904363871,0.149225918162029,0.17482698861102805,-0.09234786564055789,0.5004900437278353,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.051331995310464174,0.18355235265116157,0.7896200758961603,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP EARLY.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0520055674025804,0.13636714902072153,0.7038218959026423,-0.21887102202538,0.3228821568305408,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08612826623824218,0.024025192717835018,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP EARLY.V1 UP,157,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18529253095028725,0.15829408469358275,0.24483247824734578,-0.12913922256465127,0.49972428446522577,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03748748978940268,0.17586370642074803,0.8534526629046483,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP LATE.V1 DN,175,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.003169611604739952,0.22568038884717476,0.98882507129036,-0.45145598021107797,0.4451167570015981,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1605543892400155,-0.07902079774833899,0.9990191441902606,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC J1 UP LATE.V1 UP,179,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10929915157613454,0.060995209019193024,0.07646787944616087,-0.011860338148578883,0.23045864130084798,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.022010830392519054,0.14125476400624698,0.6296189902384475,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP EARLY.V1 DN,164,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09866675748415815,0.07676283509368062,0.20193322182981505,-0.053813184454332724,0.251146699422649,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.11331287464770205,0.20623882138606123,0.8177134279159035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP EARLY.V1 UP,160,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16575733198932507,0.18196808428681677,0.3647471667534077,-0.19569991347132915,0.5272145774499792,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16630880880247612,0.0650611289367412,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP LATE.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.01682612893553956,0.17023937991165625,0.9214842515788562,-0.3213334861033661,0.35498574397444527,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0993260476918616,-0.02644249273293539,0.9905790237664834,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ESC V6.5 UP LATE.V1 UP,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12020381784418967,0.12003050361184155,0.31926776019943764,-0.1182220323637337,0.35862966805211305,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06367428138933437,0.082347398643829,0.9027017389660956,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ALK DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21338726810660372,0.12950928462143402,0.10287131244147889,-0.04386701615051117,0.47064155236371863,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.017720527050307133,0.210722195180668,0.6839484127328216,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,ALK DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10969809322710058,0.05025890878648905,0.03163524989204544,0.009864945007609621,0.20953124144659155,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.013593399796477217,0.10622762558237198,0.4256281587170453,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN MEL18 DN.V1 DN,136,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1651231510353091,0.1368186814006955,0.23060789736945192,-0.1066503519967118,0.43689665406733,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07172842484266732,0.10992185285996443,0.842940686827401,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN MEL18 DN.V1 UP,138,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.006329739250654534,0.11066603687203538,0.954513859597004,-0.2134947481620049,0.22615422666331395,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.10102495151634144,0.08884862920300131,0.9946097045025434,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1592820778984196,0.16508379127064102,0.33717408837593865,-0.16863659364639325,0.48720074944323244,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08102234036469627,0.11144921652260242,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,BMI1 DN.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.025797332857830015,0.10119592244621875,0.7993565536359051,-0.17521593560965706,0.22681060132531708,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.1234888603121276,0.14811955069673383,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEL18 DN.V1 DN,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2090238350794303,0.12182114188707105,0.08959678123530769,-0.03295889809023653,0.45100656824909713,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04783898316415546,0.16444506338357173,0.6623259037556665,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,MEL18 DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.012216849157397973,0.10657466245044775,0.9089894964355784,-0.19948062557404708,0.22391432388884305,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.10816880062364098,0.11632206073586013,0.9888301126476031,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V1 DN,165,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07151330472357637,0.10195433906611445,0.48482787839358943,-0.13100646519120293,0.2740330746383557,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09248293844490024,-0.006403313750744377,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PTEN DN.V1 UP,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13955304818987524,0.10819572472234985,0.200381359842535,-0.0753644676043661,0.3544705639841166,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06023437417817632,0.0833557561262291,0.8152881775653731,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NOTCH DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17954633428892766,0.106143082006187,0.09415379338782731,-0.031293858907744,0.3903865274855993,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.035861836894950046,0.15996247037367653,0.6707240267079618,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NOTCH DN.V1 UP,167,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1390937400849741,0.12890211127067241,0.2834106626032395,-0.11695446889941613,0.39514194906936434,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0804871752977459,0.09752823638338502,0.877125252431494,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EIF4E DN,92,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.167486287154623,0.13620479802728552,0.22199232497703184,-0.1030678119689789,0.4380403862782249,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.05374253218782355,0.15401744274474746,0.8355377918591873,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,EIF4E UP,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.1628397205958174,0.2327413109181589,0.48592453167056304,-0.6251517434930886,0.2994723023014537,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.19898925071470983,-0.28116449434207835,0.9400644974323602,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX DN.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10352626373263801,0.06829681519122364,0.13302878674629517,-0.032136969682759,0.23918949714803503,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.02144070847205141,0.0836023066274769,0.7419804415051278,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX DN.V1 UP,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08119697405004819,0.1576865927501324,0.6078530345958025,-0.23202807134692713,0.3944220194470235,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08173584297355033,0.051004895181661195,0.9536302663534211,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX NRL DN.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10128988629802796,0.1266604802609259,0.42596949611576007,-0.1503055980599655,0.35288537065602144,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10153546720524793,0.03986864533072655,0.9299900056018157,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CRX NRL DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14257948636271056,0.16945260821867855,0.40232275476461343,-0.19401730335952094,0.47917627608494207,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06633352962121965,0.13813182693187964,0.9228083763617502,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NRL DN.V1 DN,124,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09551864248725622,0.15440518566396366,0.5377100068981628,-0.2111882908394062,0.40222557581391866,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16280730340967192,-0.01592799221510631,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NRL DN.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14998024883010905,0.1832131854593912,0.4151471966035316,-0.21395023715468683,0.5139107348149049,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08352354807489935,0.10899529619679842,0.9275087100024864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.031772724073473785,0.15845413772478575,0.8415238455323684,-0.28297695512614185,0.34652240327308936,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.047785381451790364,0.08717207555616437,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB DN.V1 UP,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0260040815705348,0.2817978125101284,0.9266790465910016,-0.5337526553647252,0.5857608185057948,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.19387308349740207,-0.09221989225755316,0.9915432628301946,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P107 DN.V1 DN,116,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.037158211281743764,0.21690077234760724,0.8643569788490434,-0.3936885276852966,0.4680049502487842,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09700152514639716,-0.005260471022050827,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P107 DN.V1 UP,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.12163300264432192,0.32223729667590606,0.7067076724498251,-0.761717807062956,0.518451801774312,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.221228864984718,-0.2651621332399445,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P130 DN.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11081067629583971,0.1410142963475614,0.4340191947519395,-0.16929690041537296,0.3909182530070524,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.07490981999869874,0.07881486226149562,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RB P130 DN.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.019489251530675114,0.2383499666604749,0.9350112767144936,-0.4539636770001313,0.4929421800614815,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16006925246636022,-0.06640091558240141,0.9921544029542516,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY ASTROCYTIC,97,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16868658684117602,0.1529489125628157,0.27298095284533674,-0.13512763886677173,0.4725008125491238,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0650519709688174,0.1365375037843612,0.8700354117066056,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY ASTROGLIAL,90,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02281099960562893,0.10712327235507449,0.8318488318874853,-0.18997622130705447,0.23559822051831233,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.03082228858159109,0.05433214812443917,0.9824089645441008,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY NEURONAL,95,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.053815411655336494,0.09885319183657319,0.5874996260830174,-0.14254431025019346,0.25017513356086646,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14131462581110885,-0.06367154535257702,0.9531324349182967,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CAHOY OLIGODENDROCUTIC,85,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.024609851017916937,0.13584484607308708,0.8566437293186843,-0.2452292477671769,0.2944489498030108,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14342254307760915,-0.07098203421024302,0.9836246458712524,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RPS14 DN.V1 DN,174,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06834264506210103,0.2767602338238287,0.8055123697788809,-0.618092850781309,0.48140756065710694,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.19346770607335242,-0.1651514243970345,0.9740375132149399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,RPS14 DN.V1 UP,182,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09208639849723202,0.04804381486442014,0.05841180884397264,-0.0033467377605697207,0.18751953475503375,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.02071063846441299,0.05721538584175092,0.5641356117388143,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL15 UP.V1 DN,166,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14888447743388,0.0861658959994236,0.08740160715573228,-0.02227348986938557,0.3200424447371456,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03262951091933425,0.12747748815447527,0.6570209000268399,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL15 UP.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13057518164668566,0.11552438747443591,0.2613275688754605,-0.09889982241073811,0.3600501857041094,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08270660004391274,0.08730816705760013,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL2 UP.V1 DN,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.15760789338359554,0.12171277854878913,0.19862484981278142,-0.08415958932653153,0.39937537609372264,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10421635033735178,0.08084009587018173,0.8150559640549688,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL2 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07215369254721171,0.09103043399437698,0.4300535065453719,-0.10866708189603058,0.252974466990454,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03961519893590107,0.06481571438796685,0.9302388919528202,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL21 UP.V1 DN,163,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.14918702692789362,0.13181356399546543,0.2606908253182116,-0.11264442523519527,0.41101847909098255,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03418566816939233,0.13226735225782865,0.8669652730965864,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,IL21 UP.V1 UP,171,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.16229423240146446,0.10151644084581027,0.11335405797304886,-0.039355706492542025,0.36394417129547096,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.0509278371316643,0.1323453704983603,0.7083183987306116,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF ERK DN.V1 DN,141,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11002907756644774,0.18664206447015763,0.5569738715973548,-0.26071245535060006,0.48077061048349556,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14799601032742957,0.04352292445518201,0.949991921327294,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF ERK DN.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.08477256063450665,0.19381905020143683,0.6628721104797243,-0.30022517277674254,0.4697702940457559,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16208015161461495,-0.02442384762130121,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF UP.V1 DN,115,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20029283893280997,0.12511482097587803,0.11287127937684079,-0.04823238313284936,0.4488180609984693,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04731620716436383,0.16905737116584887,0.7080335255008432,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,PDGF UP.V1 UP,139,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.016038484661176963,0.1891884438148985,0.9326263544435001,-0.35976111801274757,0.3918380873351015,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21241121357280557,-0.10499841638801774,0.9918526261485133,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TGFB UP.V1 DN,178,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.19971983055006137,0.15055636430005237,0.18797862511735358,-0.09934189194788934,0.4987815530480121,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06948322445394563,0.17590942906014173,0.8085168201280608,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TGFB UP.V1 UP,176,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12489512510901014,0.09044652427597487,0.1707001074721185,-0.054765784409355214,0.3045560346273755,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.004084655694770406,0.14790744227893798,0.7844207095472905,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,YAP1 DN,39,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.06323852649611483,0.17409277416403948,0.7172634785067263,-0.2825753828526929,0.40905243584492257,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12091192533939353,0.021157748493143478,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,YAP1 UP,40,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.07725073052265855,0.22495382425483962,0.7320843723625734,-0.5240938678215726,0.3695924067762555,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.12138877034682062,-0.13315399880833892,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SIRNA EIF4GI DN,88,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.06519890926488592,0.19703622478814733,0.741482186688277,-0.45658716477695305,0.3261893462471812,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.2373042696366044,-0.25127218615523156,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SIRNA EIF4GI UP,87,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03761767835490232,0.2515807546579306,0.8814700693624922,-0.4621165851890062,0.5373519418988109,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1090600272886779,-0.0216163641684843,0.9867875051416815,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HOXA9 DN.V1 DN,170,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.01869594510014651,0.250637533155784,0.9407018328952513,-0.5165566150006347,0.4791647248003416,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.22757121855209603,-0.16928220752997966,0.9928146453313277,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,HOXA9 DN.V1 UP,172,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.05170997436442977,0.11105894349987891,0.6426082853822568,-0.16889497379759771,0.2723149225264572,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.13633104230741203,-0.026509367541506568,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,SINGH KRAS DEPENDENCY SIGNATURE ,20,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3339763252383967,0.15107173649459785,0.029562352106384766,0.03389087918717826,0.6340617712896152,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.625370784552066,0.8472079453525705,0.4095391815366183,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 DN,246,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07388674091114268,0.15560702513845567,0.6360463988885244,-0.23520749889092918,0.3829809807132145,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16266843944112316,-0.028561844491015443,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 NOMO DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07955616093397214,0.15138013416935278,0.6004868333145879,-0.22114187921285536,0.38025420108079966,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16711552452152542,-0.03530290171758819,0.9533164021566217,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 NOMO UP,261,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10547198017110013,0.10805175815407932,0.33159049229066906,-0.10915956372092858,0.3201035240631288,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.058783075021133176,0.06721283110878737,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 SKM DN,242,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.11498755026298743,0.12618497595439895,0.3645650694052738,-0.13566340320369322,0.3656385037296681,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.105712380618919,0.05009836554475548,0.9137080279957605,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 SKM UP,238,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.12888491038011987,0.10387810133646061,0.2178939188196121,-0.07745617695900753,0.33522599771924727,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06262598044039261,0.0917807850233847,0.8322459088982637,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,STK33 UP,254,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09980527123877961,0.10364432558433903,0.3381198605583372,-0.10607144928707646,0.3056819917646357,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06754792735085666,0.055325999364944936,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.AMP.LUNG UP.V1 DN,127,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.21992990599464676,0.16437501818636827,0.18423805054603767,-0.10658087488789988,0.5464406868771934,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.11408302715864313,0.15875789733570256,0.8040031034823788,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.AMP.LUNG UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.152725122856463,0.15750898445568615,0.3348020846144366,-0.16014712548198906,0.46559737119491507,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1485466385194463,0.027425406696413263,0.9034998483867911,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.DF.V1 DN,181,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.18708701574692743,0.12087586563823267,0.1251505770736125,-0.053018042277432315,0.4271920737712872,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.041904314318476514,0.1831359764824108,0.7261583573371491,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.DF.V1 UP,180,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.02368980841917507,0.13711162628423781,0.8632100061248282,-0.24866559363701812,0.29604521047536825,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06125600860083107,-0.02205602046672291,0.9854445582989166,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DF DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.061747482673339765,0.23564659016155964,0.793887250869523,-0.40633552054022926,0.5298304858869087,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.20145498246171753,-0.04261318756934489,0.9732342286065081,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DF UP,264,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.015268550543302034,0.1320155608260681,0.908179065093781,-0.246964143509361,0.27750124459596504,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.06010594694729261,-0.0011950879432680779,0.9887719540319797,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DN.48HRS DN,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.11131745045288412,0.19824493840966143,0.5758269836387553,-0.5051066670889615,0.2824717661831932,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21752159554510367,-0.2639631948401114,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,TBK1.DN.48HRS UP,49,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09567812888306101,0.22122233010001963,0.6664030119437552,-0.34375285367487196,0.535109111440994,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.21911524703843316,-0.030017274381270977,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,NFE2L2.V2,412,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0857646178780232,0.1528316417713711,0.5760605700758553,-0.2178166638089184,0.3893458995649648,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08761390196440458,0.03168854107057176,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,CORDENONSI YAP CONSERVED SIGNATURE,53,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,-0.09329809482662567,0.204350511304469,0.6490758306122466,-0.49921528197558623,0.3126190923223349,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04693190157631893,-0.11151269642483112,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JAK2 DN.V1 DN,113,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10795638539382114,0.24080201047909838,0.6549878198349801,-0.37036722695993235,0.5862799977475747,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.23649478599246324,-0.04575595281469026,0.9604336667767839,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,JAK2 DN.V1 UP,169,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17049030125906903,0.11570370393823143,0.14406499268897033,-0.05934089292544928,0.4003214954435873,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.04476041352548685,0.135705869273644,0.7634098210714596,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.300 UP.V1 DN,132,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20377925524929527,0.06968559729265282,0.004357188543125652,0.06535737679515385,0.3422011337034367,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.1054394257363265,0.2869144748876474,0.11724529713671669,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.300 UP.V1 UP,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0736620066460518,0.11859172229505827,0.5360606227940186,-0.16190588122400892,0.3092298945161125,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10958270855836041,-0.019167016265681076,0.9471273828544232,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.50 UP.V1 DN,44,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.2135224192456683,0.08551856933870808,0.01433119965355514,0.043650286832694146,0.38339455165864245,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.268015661400606,0.4319772481416148,0.26196406695607094,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.50 UP.V1 UP,47,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.043645702916925176,0.1098900196960393,0.6921675411234611,-0.17463732170589918,0.26192872753974955,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.14285557760818643,-0.07536725709066525,0.963305304214035,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600 UP.V1 DN,266,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.20832391958525523,0.08683623073332951,0.018477388100237257,0.03583441468074569,0.38081342448976474,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.07416228165214042,0.27429731257652623,0.3094377779318214,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600 UP.V1 UP,259,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07315222503193278,0.1304788160235425,0.576417733306815,-0.18602791425282186,0.33233236431668745,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.10745645142651465,-0.017096749582926875,0.9525219182038099,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600.LUNG.BREAST UP.V1 DN,262,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.26490605695405045,0.1452738516640645,0.0715114735473949,-0.023662603125846338,0.5534747170339472,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.0024857223368167417,0.2770996629621855,0.6190382519293574,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.600.LUNG.BREAST UP.V1 UP,269,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.0824912488337531,0.05285916240078878,0.12209270226446044,-0.022506983760877286,0.18748948142838348,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.040403696626226664,0.04950538808598141,0.7228579124835106,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.BREAST UP.V1 DN,129,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17302273576399096,0.16622719857794632,0.3006883499613664,-0.15716717393424845,0.5032126454622303,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.1291300581570879,0.07326139275808792,0.8883007525096117,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.BREAST UP.V1 UP,128,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.07829976918678931,0.0406382440423331,0.0571310000299343,-0.002423110374589643,0.15902264874816827,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.006276058850210039,0.06633904571382772,0.5594047727659663,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.KIDNEY UP.V1 DN,126,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1497304329276033,0.11730258955424352,0.20504583653704084,-0.08327675111708999,0.3827376169722966,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.018509517685931502,0.13858821334767163,0.8179445630780711,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.KIDNEY UP.V1 UP,137,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.13758880117499467,0.15383992767620666,0.37348688692312815,-0.16799531659843459,0.4431729189484239,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.16969200587720643,-0.023927116023852772,0.915824547329523,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG UP.V1 DN,133,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.4054515003885396,0.07142635409054411,1.6222969514547327e-07,0.26357182239966803,0.5473311783774112,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.21888560740066032,0.5793797627495945,1.5704625854448376e-05,0.00015008432385715643 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG UP.V1 UP,130,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.051327385672500225,0.08012939212636414,0.523420756034265,-0.10783980824476053,0.21049457958976098,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.08160266018310407,-0.014017558743570737,0.9438759903131516,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG.BREAST UP.V1 DN,131,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.3120968418745945,0.14374797289335414,0.032522544901550744,0.026559152525249208,0.5976345312239398,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,0.0779353749640104,0.38241008476893185,0.4331610091082379,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.LUNG.BREAST UP.V1 UP,135,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.03920835554892808,0.029667709937435057,0.18961985643926427,-0.019722905694711107,0.09813961679256726,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03366511540442057,0.0026325392628180236,0.8114284597256536,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.PROSTATE UP.V1 DN,134,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.17899191513160684,0.04941791753879043,0.0004807335425729012,0.08082929271361043,0.27715453754960323,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.006136780825132431,0.17545440904071805,0.0194697084742025,0.18606607117729834 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,KRAS.PROSTATE UP.V1 UP,123,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.09673949142988889,0.11378136339667715,0.39743280672055836,-0.12927320941987328,0.322752192279651,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.09841154439937956,0.027134498956625137,0.9212557438608796,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LEF1 UP.V1 DN,177,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.1925204342866247,0.13661709274948208,0.16218497456180667,-0.07885263765403583,0.4638935062272852,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.03728703648379339,0.1657593008728859,0.7815068115919459,1.0 +ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,LEF1 UP.V1 UP,188,mean z-scored log1p TPM across measured pathway genes,DepMap_24Q4_expression,TESTED,0.10943648560805469,0.0922648856410343,0.23866576477541546,-0.07383637538434215,0.29270934660045156,90,5,95,2,log_other_mut_burden|lin_Uterus,False,91,-0.011488950376866359,0.09877941466966922,0.8459452857747916,1.0 diff --git a/results/Therapeutic/02_Oncogenic_Pathway_Activity/Pathway_Summary.json b/results/Therapeutic/02_Oncogenic_Pathway_Activity/Pathway_Summary.json new file mode 100644 index 0000000000000000000000000000000000000000..c9a0cd0b34e9b2814d62be5d1376ee92d4ac746f --- /dev/null +++ b/results/Therapeutic/02_Oncogenic_Pathway_Activity/Pathway_Summary.json @@ -0,0 +1,15 @@ +{ + "file": "/kaggle/working/final_comutation_fresh_20261104_192636_UTC/raw/OmicsExpressionProteinCodingGenesTPMLogp1.csv", + "n_expression_models": 1673, + "n_expression_gene_symbols": 9899, + "pathway_set": { + "provider": "Enrichr_MSigDB_Oncogenic_Signatures", + "url": "https://maayanlab.cloud/Enrichr/geneSetLibrary?mode=text&libraryName=MSigDB_Oncogenic_Signatures", + "n_loaded": 189 + }, + "n_pathways_tested": 189, + "n_hypotheses_tested": 7938, + "n_BH_05": 235, + "n_BY_05": 167, + "interpretation": "Associations of pathway expression activity, not verified pathway rewiring or mediation" +} \ No newline at end of file diff --git a/results/Therapeutic/02_Oncogenic_Pathway_Activity/gene_set_provenance.json b/results/Therapeutic/02_Oncogenic_Pathway_Activity/gene_set_provenance.json new file mode 100644 index 0000000000000000000000000000000000000000..ee4867d61db14dd9c2272bd2ed8ad5c63b81dbf4 --- /dev/null +++ b/results/Therapeutic/02_Oncogenic_Pathway_Activity/gene_set_provenance.json @@ -0,0 +1,5 @@ +{ + "provider": "Enrichr_MSigDB_Oncogenic_Signatures", + "url": "https://maayanlab.cloud/Enrichr/geneSetLibrary?mode=text&libraryName=MSigDB_Oncogenic_Signatures", + "n_loaded": 189 +} \ No newline at end of file diff --git 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DN,-0.07640796791636882,0.018006458142230296,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,STK33 SKM DN,-0.06672106795817245,0.04234903760676014,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.AMP.LUNG UP.V1 DN,-0.08088573259543838,0.004415719320574377,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.AMP.LUNG UP.V1 UP,-0.11416178475898245,1.0280327455732904e-06,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.DF.V1 DN,-0.09110291704284254,0.0014806640011692412,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,TBK1.DN.48HRS UP,-0.10327768449041065,0.057765320986437003,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,NFE2L2.V2,-0.07879253534759546,0.0033565884845905706,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,JAK2 DN.V1 DN,-0.11885804773088685,0.0037290324694380043,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,JAK2 DN.V1 UP,-0.08872328376656621,8.373911485567118e-05,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.300 UP.V1 DN,-0.06317332190729279,0.061219364438498916,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.300 UP.V1 UP,-0.06376131963905293,0.074183466974028,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.600 UP.V1 DN,-0.08661689794600387,0.00031325395852614636,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.600.LUNG.BREAST UP.V1 DN,-0.11138126671471574,5.274283770473584e-06,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.BREAST UP.V1 DN,-0.10112014465293015,3.3945849096372593e-05,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.KIDNEY UP.V1 UP,-0.1729792225748024,1.102272258046489e-06,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.LUNG UP.V1 DN,-0.10711371714901644,0.0002833996963121624,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.LUNG.BREAST UP.V1 DN,-0.10305553864060928,0.00015979389461704454,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.PROSTATE UP.V1 DN,-0.08259330155002541,0.00027720492715521775,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KRAS,KRAS,-1.0865308434948422,1.053430644354516e-22,KRAS.PROSTATE UP.V1 UP,-0.056343650682681046,0.03287906845120848,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,PIK3CA,PIK3CA,-0.6206702665037973,8.899927369258888e-08,KRAS.50 UP.V1 UP,-0.0835548238232221,0.043314562335282296,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,NRAS,NRAS,-1.3350632067960593,6.664587881992054e-07,P53 DN.V1 DN,0.11414536599766043,0.06374504020225781,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,NRAS,NRAS,-1.3350632067960593,6.664587881992054e-07,KRAS.DF.V1 UP,0.12242256787939126,0.050556612065874224,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,ASTN1,PRR35,-0.1507807162573974,3.417850152325546e-05,ESC J1 UP LATE.V1 UP,-0.09557452887559854,0.09089790722071839,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,CNBP,-0.3940936007462384,5.042486238696814e-05,BCAT.100 UP.V1 DN,0.16935006269396274,0.00588655122124249,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,CNBP,-0.3940936007462384,5.042486238696814e-05,CAHOY NEURONAL,0.09689283946783707,0.015033219160481441,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,NBN,DOK1,-0.1548810330665694,9.075594194213218e-05,BCAT BILD ET AL DN,0.21576356570581273,0.017682532570199628,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,PPIB,-0.2400078629565078,0.00012827981150302574,BCAT.100 UP.V1 DN,0.16935006269396274,0.00588655122124249,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,PPIB,-0.2400078629565078,0.00012827981150302574,CAHOY NEURONAL,0.09689283946783707,0.015033219160481441,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,HES2,-0.1669111320160176,0.00022322391960788527,BCAT.100 UP.V1 DN,0.16935006269396274,0.00588655122124249,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,HES2,-0.1669111320160176,0.00022322391960788527,CAHOY NEURONAL,0.09689283946783707,0.015033219160481441,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,E2F1 UP.V1 DN,0.2280188804608498,0.028989552407043692,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,EGFR UP.V1 UP,0.2554682372504214,0.04997417188791553,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,GCNP SHH UP LATE.V1 DN,0.16732468723305846,0.003730369421715205,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,CYCLIN D1 KE .V1 UP,0.17833606273331995,0.06441079442033786,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,P53 DN.V1 UP,0.1534906646462953,0.004236015630109969,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,BCAT BILD ET AL DN,0.3132419035669142,0.09145608424256206,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,ESC J1 UP EARLY.V1 DN,0.18672635343143928,0.07966401730943237,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,ESC J1 UP LATE.V1 UP,0.1415871850429061,0.007254849161155216,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,ESC V6.5 UP EARLY.V1 DN,0.17890367996030584,0.04111530260204601,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,EIF4E DN,0.2632392911480158,0.06508448838028992,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,CRX NRL DN.V1 UP,0.18578775870058875,0.034050816466136495,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,RB DN.V1 DN,0.245631252998349,9.588888840875711e-05,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,RPS14 DN.V1 UP,0.10094888776757545,0.04239638330849508,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,OR6S1,-0.1479065712039866,0.0013460748033845657,KRAS.DF.V1 UP,0.15491911387248883,0.019543872940344854,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,TP53,TP53,-0.6690480767468656,0.0017146919743462076,P53 DN.V1 DN,-0.12220070171725991,0.07655187135759178,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,CTNNA2,L2HGDH,-0.1757264475669163,0.0017325836074440204,CORDENONSI YAP CONSERVED SIGNATURE,-0.16895948148287968,0.00015979389461704454,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,CTNNA2,OR1E1,-0.1654319972269921,0.0023183994508685422,CORDENONSI YAP CONSERVED SIGNATURE,-0.16895948148287968,0.00015979389461704454,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,E2F1 UP.V1 DN,0.2280188804608498,0.028989552407043692,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,EGFR UP.V1 UP,0.2554682372504214,0.04997417188791553,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,GCNP SHH UP LATE.V1 DN,0.16732468723305846,0.003730369421715205,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,CYCLIN D1 KE .V1 UP,0.17833606273331995,0.06441079442033786,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,P53 DN.V1 UP,0.1534906646462953,0.004236015630109969,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,BCAT BILD ET AL DN,0.3132419035669142,0.09145608424256206,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,ESC J1 UP EARLY.V1 DN,0.18672635343143928,0.07966401730943237,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,ESC J1 UP LATE.V1 UP,0.1415871850429061,0.007254849161155216,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,ESC V6.5 UP EARLY.V1 DN,0.17890367996030584,0.04111530260204601,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,EIF4E DN,0.2632392911480158,0.06508448838028992,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,CRX NRL DN.V1 UP,0.18578775870058875,0.034050816466136495,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,RB DN.V1 DN,0.245631252998349,9.588888840875711e-05,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,RPS14 DN.V1 UP,0.10094888776757545,0.04239638330849508,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,KCNT2,NEFH,-0.1811065538630737,0.0024689738843506445,KRAS.DF.V1 UP,0.15491911387248883,0.019543872940344854,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,LRRIQ3,ASIC3,-0.0915714228989641,0.0029856584920047316,GCNP SHH UP LATE.V1 DN,0.191869409441335,0.003916470266121944,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,LRRIQ3,ASIC3,-0.0915714228989641,0.0029856584920047316,PTEN DN.V1 UP,0.13387926926029864,0.059922001836761295,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,LRRIQ3,ASIC3,-0.0915714228989641,0.0029856584920047316,TGFB UP.V1 DN,0.14227023282194426,0.09909254586802571,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,LRRIQ3,ASIC3,-0.0915714228989641,0.0029856584920047316,LEF1 UP.V1 DN,0.14298309881946988,0.048607172223437634,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,AGRP,-0.1536190146750028,0.003035639666274923,BCAT.100 UP.V1 DN,0.16935006269396274,0.00588655122124249,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,AGRP,-0.1536190146750028,0.003035639666274923,CAHOY NEURONAL,0.09689283946783707,0.015033219160481441,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,ASTN1,NEUROG3,-0.1188177004811183,0.003211078136015221,ESC J1 UP LATE.V1 UP,-0.09557452887559854,0.09089790722071839,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,LHFPL6,-0.2818135194007482,0.004103290745428759,BCAT.100 UP.V1 DN,0.16935006269396274,0.00588655122124249,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TERT,ATM,LHFPL6,-0.2818135194007482,0.004103290745428759,CAHOY NEURONAL,0.09689283946783707,0.015033219160481441,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,NBN,PLA2G4D,-0.1880413094768296,0.004103290745428759,BCAT BILD ET AL DN,0.21576356570581273,0.017682532570199628,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +BRAF,TP53,TP53,-0.8569077390316492,0.004497865529228015,MTOR UP.V1 UP,0.11700586457635939,0.06954343095346341,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +BRAF,TP53,TP53,-0.8569077390316492,0.004497865529228015,PRC2 EZH2 UP.V1 UP,0.15990877340973647,0.0615132762373489,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +BRAF,TP53,TP53,-0.8569077390316492,0.004497865529228015,RB P107 DN.V1 UP,0.2152218041656969,0.07911164839882295,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +BRAF,TP53,TP53,-0.8569077390316492,0.004497865529228015,RPS14 DN.V1 DN,0.18791294465506986,0.08173551497557302,False,EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION +TP53,RB1,E2F3,-0.5449616367402317,0.004497865529228015,GLI1 UP.V1 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iproniazid,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:5925,TP53,RB1,ENTREZ:1871,E2F3,-0.5449616367402317,0.004497865529228015,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:401089,FOXL2NB,-0.1374364504290243,0.004497865529228015,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:324,ENTREZ:10664,APC,CTCF,ENTREZ:644591,PPIAL4G,-0.2444700948887266,0.004762736490852514,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:324,ENTREZ:84159,APC,ARID5B,ENTREZ:116238,TLCD1,-0.2898273088966892,0.005059993762163352,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY 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+ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,ENTREZ:23097,CDK19,-0.0833633961359934,0.007177934841272493,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:8706,B3GALNT1,-0.1077295170110197,0.008354069775512124,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:80243,TP53,PREX2,ENTREZ:10542,LAMTOR5,-0.0787500030745661,0.008555542406958768,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,ENTREZ:124446,TMEM219,-0.1348543304511846,0.010700306281728517,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:4850,CNOT4,-0.216565427692534,0.010700306281728517,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7273,ENTREZ:7157,TTN,TP53,ENTREZ:7157,TP53,-0.5935115896585544,0.011416622719899565,3,3,0,2.0,3,nutlin-3 | aspirin | idasanutlin,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,ENTREZ:64757,MTARC1,-0.1974744369246595,0.012334690527669378,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,ENTREZ:23219,FBXO28,-0.214505765929011,0.014323788392779313,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:23521,RPL13A,-0.3952742324314789,0.015161818285072143,2,2,0,13.0,2,puromycin | anisomycin,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY 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+ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:283092,OR4C13,-0.1230702768483216,0.020745789289440705,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,ENTREZ:401089,FOXL2NB,-0.1381501063083409,0.021722243286244475,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:7158,TP53BP1,-0.267368024970112,0.021822300574845736,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,ENTREZ:4893,NRAS,-1.43378483684841,0.02245943944149391,1,0,0,4.0,1,lonafarnib,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,ENTREZ:91612,CHURC1,-0.237494447867264,0.02352899537146925,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:387,TP53,RHOA,ENTREZ:135250,RAET1E,-0.1145894515087665,0.02502065744022866,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,ENTREZ:3346,HTN1,-0.1259886601883399,0.025388289085472953,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7015,ENTREZ:472,TERT,ATM,ENTREZ:2237,FEN1,-0.4536906371662967,0.028287370223935234,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:546,TP53,ATRX,ENTREZ:29993,PACSIN1,-0.0883223839402675,0.028287370223935234,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,ENTREZ:55111,PLEKHJ1,-0.0988522423899898,0.029390311196173163,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY 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+ENTREZ:7015,ENTREZ:7157,TERT,TP53,ENTREZ:1026,CDKN1A,-0.3248516515795884,0.04898412473432724,1,1,0,1.0,1,GGTI-298,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:460,TP53,ASTN1,ENTREZ:124975,GGT6,-0.1387908150420942,0.04899759208028155,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ENTREZ:1843,DUSP1,-0.1644311717459073,0.04940920548690533,0,0,0,,0,,PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET,COMPUTATIONAL_PRIORITIZATION_ONLY diff --git a/results/Therapeutic/05_TCGA_CoMutation_Prevalence/Selected_TCGA_Study_Patient_Mutation_Cooccurrence.csv b/results/Therapeutic/05_TCGA_CoMutation_Prevalence/Selected_TCGA_Study_Patient_Mutation_Cooccurrence.csv new file mode 100644 index 0000000000000000000000000000000000000000..49ecd81ae7e1d6b38e0029ec2a59381313b30876 --- /dev/null +++ b/results/Therapeutic/05_TCGA_CoMutation_Prevalence/Selected_TCGA_Study_Patient_Mutation_Cooccurrence.csv @@ -0,0 +1,169 @@ +Study,A,B,A_symbol,B_symbol,n_mutation_profile_patients,n_A_any_reported_nonsilent,n_B_any_reported_nonsilent,n_AB_any_reported_nonsilent,AB_fraction,sample_list,sample_list_is_sequenced,TCGA_mutation_definition,interpretation +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,1066,347,6,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,1066,6,7,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,1066,347,347,81,0.07598499061913697,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,1066,347,4,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,1066,347,24,11,0.010318949343339587,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,1066,347,10,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,1066,347,10,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,1066,347,11,6,0.005628517823639775,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,1066,347,22,9,0.008442776735459663,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,1066,347,2,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,1066,6,25,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,1066,347,26,9,0.008442776735459663,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,1066,347,7,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,1066,14,9,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,1066,347,19,10,0.009380863039399626,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,1066,347,15,6,0.005628517823639775,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,1066,6,347,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,1066,347,13,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,1066,347,8,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,1066,347,14,5,0.004690431519699813,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,1066,347,30,11,0.010318949343339587,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,1066,7,347,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,1066,347,25,15,0.014071294559099437,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,1066,14,22,0,0.0,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,1066,14,7,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,1066,14,15,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,1066,347,2,0,0.0,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,1066,14,6,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,1066,347,11,5,0.004690431519699813,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,1066,187,347,83,0.07786116322701689,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,1066,347,42,7,0.006566604127579738,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,1066,347,8,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,1066,347,5,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,1066,347,6,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,1066,347,130,9,0.008442776735459663,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,1066,6,36,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,1066,347,8,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,1066,6,4,2,0.001876172607879925,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,1066,0,109,0,0.0,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,1066,347,14,4,0.00375234521575985,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,1066,14,17,1,0.0009380863039399625,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +brca_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,1066,347,10,3,0.0028142589118198874,brca_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,566,295,168,62,0.10954063604240283,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,566,6,41,1,0.0017667844522968198,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,566,295,28,15,0.026501766784452298,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,566,295,4,3,0.00530035335689046,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,566,295,34,24,0.04240282685512368,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,566,295,17,12,0.02120141342756184,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,566,295,37,32,0.05653710247349823,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,566,295,71,44,0.07773851590106007,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,566,295,80,55,0.09717314487632508,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,566,295,21,7,0.012367491166077738,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,566,6,47,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,566,295,30,22,0.038869257950530034,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,566,295,6,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,566,34,14,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,566,295,59,45,0.07950530035335689,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,566,295,11,7,0.012367491166077738,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,566,6,295,6,0.01060070671378092,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,566,295,64,45,0.07950530035335689,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,566,295,32,23,0.04063604240282685,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,566,295,17,13,0.022968197879858657,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,566,295,65,49,0.08657243816254417,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,566,41,295,26,0.045936395759717315,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,566,295,34,31,0.054770318021201414,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,566,34,5,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,566,34,9,1,0.0017667844522968198,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,566,34,16,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,566,295,2,1,0.0017667844522968198,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,566,34,11,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,566,295,33,21,0.037102473498233215,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,566,272,295,181,0.3197879858657244,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,566,295,8,7,0.012367491166077738,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,566,295,5,4,0.007067137809187279,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,566,295,11,8,0.014134275618374558,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,566,295,15,10,0.0176678445229682,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,566,295,6,6,0.01060070671378092,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,566,6,201,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,566,295,5,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,566,6,4,0,0.0,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,566,25,242,17,0.030035335689045935,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,566,295,11,6,0.01060070671378092,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,566,34,72,5,0.0088339222614841,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +luad_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,566,295,16,14,0.024734982332155476,luad_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,534,314,218,125,0.2340823970037453,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,534,6,62,4,0.00749063670411985,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,534,314,147,66,0.12359550561797752,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,534,314,33,20,0.03745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,534,314,36,17,0.031835205992509365,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,534,314,18,7,0.013108614232209739,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,534,314,23,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,534,314,42,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,534,314,34,20,0.03745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,534,314,33,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,534,6,70,3,0.0056179775280898875,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,534,314,41,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,534,314,11,4,0.00749063670411985,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,534,387,24,20,0.03745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,534,314,30,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,534,314,24,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,534,6,314,2,0.003745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,534,314,36,18,0.033707865168539325,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,534,314,28,14,0.026217228464419477,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,534,314,26,14,0.026217228464419477,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,534,314,62,26,0.04868913857677903,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,534,62,314,25,0.04681647940074907,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,534,314,14,7,0.013108614232209739,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,534,387,20,13,0.024344569288389514,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,534,387,17,13,0.024344569288389514,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,534,387,23,16,0.0299625468164794,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,534,314,2,1,0.0018726591760299626,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,534,387,18,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,534,314,33,9,0.016853932584269662,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,534,257,314,151,0.28277153558052437,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,534,314,27,14,0.026217228464419477,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,534,314,6,1,0.0018726591760299626,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,534,314,15,3,0.0056179775280898875,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,534,314,15,9,0.016853932584269662,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,534,314,19,6,0.011235955056179775,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,534,6,94,4,0.00749063670411985,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,534,314,14,7,0.013108614232209739,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,534,6,33,0,0.0,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,534,3,146,2,0.003745318352059925,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,534,314,23,11,0.020599250936329586,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,534,387,45,29,0.054307116104868915,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +coadread_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,534,314,14,10,0.018726591760299626,coadread_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3845,TP53,KRAS,438,72,10,1,0.00228310502283105,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:673,TERT,BRAF,438,19,233,12,0.0273972602739726,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,438,72,22,6,0.0136986301369863,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4893,TP53,NRAS,438,72,125,25,0.05707762557077625,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:546,TP53,ATRX,438,72,37,14,0.0319634703196347,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:83990,TP53,BRIP1,438,72,26,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,438,72,61,19,0.04337899543378995,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:26047,TP53,CNTNAP2,438,72,102,30,0.0684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:460,TP53,ASTN1,438,72,86,24,0.0547945205479452,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1499,TP53,CTNNB1,438,72,30,5,0.01141552511415525,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:472,TERT,ATM,438,19,42,4,0.0091324200913242,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:80243,TP53,PREX2,438,72,101,26,0.0593607305936073,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:4683,TP53,NBN,438,72,10,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9585,APC,KIF20B,438,61,29,10,0.0228310502283105,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:343450,TP53,KCNT2,438,72,85,26,0.0593607305936073,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,438,72,48,13,0.02968036529680365,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:7157,TERT,TP53,438,19,72,4,0.0091324200913242,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:1496,TP53,CTNNA2,438,72,49,14,0.0319634703196347,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,438,72,52,19,0.04337899543378995,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:158358,TP53,KIAA2026,438,72,25,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:84162,TP53,BLTP1,438,72,98,26,0.0593607305936073,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:673,ENTREZ:7157,BRAF,TP53,438,233,72,37,0.08447488584474885,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:5925,TP53,RB1,438,72,22,5,0.01141552511415525,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:10664,APC,CTCF,438,61,10,3,0.00684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:84159,APC,ARID5B,438,61,26,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:55252,APC,ASXL2,438,61,30,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:896,TP53,CCND3,438,72,3,1,0.00228310502283105,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:7468,APC,NSD2,438,61,33,11,0.02511415525114155,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3739,TP53,KCNA4,438,72,19,3,0.00684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7273,ENTREZ:7157,TTN,TP53,438,351,72,70,0.1598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:6416,TP53,MAP2K4,438,72,13,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:387,TP53,RHOA,438,72,5,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:81930,TP53,KIF18A,438,72,18,4,0.0091324200913242,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:3717,TP53,JAK2,438,72,21,8,0.0182648401826484,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:999,TP53,CDH1,438,72,15,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:53353,TERT,LRP1B,438,19,205,13,0.02968036529680365,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:345895,TP53,RSPH4A,438,72,14,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7015,ENTREZ:4893,TERT,NRAS,438,19,125,2,0.0045662100456621,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:1029,ENTREZ:94025,CDKN2A,MUC16,438,59,325,51,0.11643835616438356,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:54790,TP53,TET2,438,72,36,7,0.01598173515981735,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:324,ENTREZ:9699,APC,RIMS2,438,61,70,12,0.0273972602739726,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence +skcm_tcga_pan_can_atlas_2018,ENTREZ:7157,ENTREZ:8028,TP53,MLLT10,438,72,20,3,0.00684931506849315,skcm_tcga_pan_can_atlas_2018_sequenced,True,Any reported nonsilent mutation; different from DepMap damaging/hotspot,Descriptive prevalence in the selected TCGA study; not drug-response evidence diff --git a/results/Therapeutic/05_TCGA_CoMutation_Prevalence/TCGA_provenance_and_coverage.json b/results/Therapeutic/05_TCGA_CoMutation_Prevalence/TCGA_provenance_and_coverage.json new file mode 100644 index 0000000000000000000000000000000000000000..03f0aadf20241613097453fb6ad28d28efa413a7 --- /dev/null +++ b/results/Therapeutic/05_TCGA_CoMutation_Prevalence/TCGA_provenance_and_coverage.json @@ -0,0 +1,35 @@ +{ + "studies": [ + { + "study": "brca_tcga_pan_can_atlas_2018", + "status": "COMPUTED", + "sample_list": "brca_tcga_pan_can_atlas_2018_sequenced", + "n_samples": 1066, + "n_patients": 1066 + }, + { + "study": "luad_tcga_pan_can_atlas_2018", + "status": "COMPUTED", + "sample_list": "luad_tcga_pan_can_atlas_2018_sequenced", + "n_samples": 566, + "n_patients": 566 + }, + { + "study": "coadread_tcga_pan_can_atlas_2018", + "status": "COMPUTED", + "sample_list": "coadread_tcga_pan_can_atlas_2018_sequenced", + "n_samples": 534, + "n_patients": 534 + }, + { + "study": "skcm_tcga_pan_can_atlas_2018", + "status": "COMPUTED", + "sample_list": "skcm_tcga_pan_can_atlas_2018_sequenced", + "n_samples": 440, + "n_patients": 438 + } + ], + "not_pan_cancer_prevalence": true, + "no_normal_coverage_implied": true, + "no_drug_efficacy_inferred": true +} \ No newline at end of file diff --git a/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_Leave_One_Lineage_Out_Robustness.csv b/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_Leave_One_Lineage_Out_Robustness.csv new file mode 100644 index 0000000000000000000000000000000000000000..f2d639b2ae43a6d8d24321dc06214c32bd4b40b7 --- /dev/null +++ b/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_Leave_One_Lineage_Out_Robustness.csv @@ -0,0 +1,50 @@ +A,B,TargetGene,DrugID,Dataset,original_beta,n_refits_attempted,n_refits_tested,fraction_direction_stable,max_abs_change_in_beta,robustness_status,nonestimable_reason_categories +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,-0.06355575129029015,21,21,1.0,0.03714181496925724,COMPUTED, +ENTREZ:7015,ENTREZ:673,BRAF,BRD-A56085258-001-01-8,PRISM_19Q4_secondary_AUC,-0.278603797467874,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K05804044-001-06-0,PRISM_19Q4_secondary_AUC,-0.06755832411538915,15,13,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K05804044-001-18-5,PRISM_19Q4_secondary_AUC,-0.11480626283805168,15,13,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=2) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K09951645-001-06-8,PRISM_19Q4_secondary_AUC,-0.2680466571687501,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=17)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K09951645-001-11-8,PRISM_19Q4_secondary_AUC,-0.19485059759395473,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K16478699-001-09-2,PRISM_19Q4_secondary_AUC,-0.042815316735061726,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K16730910-001-07-3,PRISM_19Q4_secondary_AUC,0.0608785982840076,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K20722021-001-02-1,PRISM_19Q4_secondary_AUC,-0.2575342741202116,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K23984367-075-15-2,PRISM_19Q4_secondary_AUC,0.10241351244512537,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=14)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K31866293-001-01-6,PRISM_19Q4_secondary_AUC,-0.08381094638232552,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K56343971-001-14-8,PRISM_19Q4_secondary_AUC,-0.09231426695639348,15,13,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)" +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K93123848-001-04-1,PRISM_19Q4_secondary_AUC,-0.006007501054305777,16,14,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=3) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)" +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K07310275-001-02-5,PRISM_19Q4_secondary_AUC,-0.004511552670644972,21,21,0.9523809523809523,0.0054519550461942096,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K07955840-001-02-3,PRISM_19Q4_secondary_AUC,-0.027566942881536292,21,21,1.0,0.006814958719966936,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K07972848-001-02-0,PRISM_19Q4_secondary_AUC,-0.055271610176778785,20,20,1.0,0.01274361022423847,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K12184916-001-15-4,PRISM_19Q4_secondary_AUC,-0.02161755553951482,21,21,1.0,0.014834791779293546,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K12184916-001-19-6,PRISM_19Q4_secondary_AUC,-0.026994492518277104,20,20,1.0,0.02380031274403316,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K23228615-001-02-8,PRISM_19Q4_secondary_AUC,-0.09875185900944551,21,21,1.0,0.02893807332001462,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K28352084-001-02-3,PRISM_19Q4_secondary_AUC,-0.05314514117878644,20,20,1.0,0.005766550384565153,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K29415052-050-04-8,PRISM_19Q4_secondary_AUC,-0.02539981880195419,21,21,1.0,0.009581162284818267,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K42191735-001-05-3,PRISM_19Q4_secondary_AUC,-0.01277438153136131,21,21,1.0,0.006859806381718306,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K43187018-001-03-3,PRISM_19Q4_secondary_AUC,0.0035514063092775133,21,21,0.9047619047619048,0.010941062878597507,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K44844162-001-01-6,PRISM_19Q4_secondary_AUC,-0.16922341588870116,21,21,1.0,0.027029462294654277,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K49371609-003-03-8,PRISM_19Q4_secondary_AUC,-0.00870896987008303,21,21,1.0,0.004463392934041771,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K52911425-001-09-8,PRISM_19Q4_secondary_AUC,-0.0438056849247698,21,21,1.0,0.015248189027349944,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K54997624-001-06-0,PRISM_19Q4_secondary_AUC,-0.08071036408300722,21,21,1.0,0.011386555887014815,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K56291712-001-01-0,PRISM_19Q4_secondary_AUC,-0.10756995225192827,21,21,1.0,0.04324732607652319,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K58772419-001-07-0,PRISM_19Q4_secondary_AUC,-0.004302021342307895,21,21,0.9047619047619048,0.0139770778362214,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K59317601-001-05-5,PRISM_19Q4_secondary_AUC,-0.02389487429180874,21,21,1.0,0.016153195305462713,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K60866521-001-07-1,PRISM_19Q4_secondary_AUC,0.0023312811757984983,21,21,0.8095238095238095,0.009346509981203453,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K64785675-001-04-0,PRISM_19Q4_secondary_AUC,0.05042339181015042,20,20,1.0,0.026711310616218634,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K67868012-001-07-6,PRISM_19Q4_secondary_AUC,-0.02134036251741895,21,21,1.0,0.010346099250182365,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K81801188-001-02-8,PRISM_19Q4_secondary_AUC,-0.008218093153964368,21,21,1.0,0.011750914512131946,COMPUTED, +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K98795921-001-01-7,PRISM_19Q4_secondary_AUC,-0.03000315966845361,21,21,1.0,0.0029499493719670304,COMPUTED, +ENTREZ:7157,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,-0.018788969323724994,21,20,1.0,0.019183929873615085,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=10,n1=4)" +ENTREZ:7015,ENTREZ:7157,CDKN1A,BRD-K19669037-001-01-1,PRISM_19Q4_secondary_AUC,-0.09632427585715136,14,14,1.0,0.06367870060584271,COMPUTED, +ENTREZ:7015,ENTREZ:7157,TP53,BRD-A12230535-001-06-7,PRISM_19Q4_secondary_AUC,0.2436267708867489,16,16,1.0,0.07309121860077913,COMPUTED, +ENTREZ:7015,ENTREZ:7157,TP53,BRD-K11433652-001-17-0,PRISM_19Q4_secondary_AUC,-0.07521611925019966,16,16,1.0,0.1023460415603967,COMPUTED, +ENTREZ:7015,ENTREZ:7157,TP53,BRD-K62627508-001-01-5,PRISM_19Q4_secondary_AUC,0.32352405801683065,16,16,1.0,0.05185333670679099,COMPUTED, +ENTREZ:7157,ENTREZ:127255,ASIC3,BRD-K11433652-001-17-0,PRISM_19Q4_secondary_AUC,0.05463896840826776,21,19,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=13,n1=2) | SPARSE_AFTER_LINEAGE_OVERLAP(n0=65,n1=3)" +ENTREZ:673,ENTREZ:7157,TP53,BRD-A12230535-001-06-7,PRISM_19Q4_secondary_AUC,0.4088092766436812,11,10,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)" +ENTREZ:673,ENTREZ:7157,TP53,BRD-K11433652-001-17-0,PRISM_19Q4_secondary_AUC,-0.19959813366378149,10,9,1.0,0.0,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)" +ENTREZ:673,ENTREZ:7157,TP53,BRD-K62627508-001-01-5,PRISM_19Q4_secondary_AUC,0.3295235041665884,11,10,1.0,0.04109905083556065,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=2)" +ENTREZ:7273,ENTREZ:7157,TP53,BRD-A12230535-001-06-7,PRISM_19Q4_secondary_AUC,0.30768660066712955,17,17,1.0,0.037433291505226174,COMPUTED, +ENTREZ:7273,ENTREZ:7157,TP53,BRD-K11433652-001-17-0,PRISM_19Q4_secondary_AUC,-0.01262960032266958,17,17,0.9411764705882353,0.024278954441885412,COMPUTED, +ENTREZ:7273,ENTREZ:7157,TP53,BRD-K62627508-001-01-5,PRISM_19Q4_secondary_AUC,0.2963089310054027,17,17,1.0,0.021486034392007136,COMPUTED, +ENTREZ:7157,ENTREZ:387,RPL13A,BRD-A28970875-300-04-9,PRISM_19Q4_secondary_AUC,0.011078445608502512,21,20,1.0,0.013124110762407121,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=33,n1=4)" +ENTREZ:7157,ENTREZ:387,RPL13A,BRD-K91370081-001-25-1,PRISM_19Q4_secondary_AUC,0.004680246913723334,21,20,1.0,0.018651098562587926,COMPUTED,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=32,n1=4)" diff --git a/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_drug_response_HC3_BH_BY.csv b/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_drug_response_HC3_BH_BY.csv new file mode 100644 index 0000000000000000000000000000000000000000..70120be3a0586d173a3b7e790140322e256b6f05 --- /dev/null +++ b/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_drug_response_HC3_BH_BY.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,DrugID,DrugName,DrugTargets,C1_beta,C1_global_BY_q,MultitargetFlag,NAnnotatedTargets,Dataset,fit_status,beta_AB_vs_Aonly,hc3_se,p,ci_low,ci_high,n10,n11,n_total,n_lineages,adjusted_for,burden_not_adjusted_due_to_collinearity,fit_df_resid,mean10,mean11,n_screen_matched_models,response_scale,n_available,q_global_BH,q_global_BY,direction_consistent_with_C1,support_status +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.0865308434948422,1.053430644354516e-22,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.06355575129029015,0.03206315437996855,0.04901271427889244,-0.12683348903734784,-0.00027801354323245264,141.0,43.0,184.0,6.0,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,176.0,0.9195063046431765,0.855124561038948,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.12640121050872263,0.5661769768819717,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-A56085258-001-01-8,LGX818,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.278603797467874,0.16755002645372075,0.10991990606236826,-0.625207434817275,0.06799983988152702,6.0,21.0,27.0,2.0,log_other_mut_burden|lin_Thyroid,False,23.0,0.9710419438249515,0.6457935031085813,93,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.2154430158822418,0.9650135068455283,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.06755832411538915,0.03576138243317454,0.07154599731817549,-0.14153638004488145,0.006419731814103158,6.0,21.0,27.0,2.0,log_other_mut_burden|lin_Thyroid,False,23.0,0.8636105882248012,0.7881929224335729,93,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.16694066040907615,0.7477614972885734,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.11480626283805168,0.07874397129939525,0.15897774916984675,-0.2781112641756742,0.04849873849957084,6.0,20.0,26.0,2.0,log_other_mut_burden|lin_Thyroid,False,22.0,0.8140166587975016,0.6730185905149428,87,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.26861757618353416,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.2680466571687501,0.15327937789152404,0.09427629408302855,-0.5859286308430638,0.049835316505563665,6.0,20.0,26.0,2.0,log_other_mut_burden|lin_Thyroid,False,22.0,1.0114696267269159,0.6560785007408431,87,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.1924807670861833,0.8621608794581748,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.19485059759395473,0.09610885122133443,0.054363533092143014,-0.39366690410159955,0.0039657089136900525,6.0,21.0,27.0,2.0,log_other_mut_burden|lin_Thyroid,False,23.0,0.8224714285349952,0.5226571548975281,84,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.13319065607575037,0.5965882977100995,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.042815316735061726,0.03990378092312767,0.2939579018976514,-0.12517267278582456,0.03954203931570112,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.8699215814632142,0.818547945370785,95,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.4501230372807788,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,True,18,PRISM_19Q4_secondary_AUC,TESTED,0.0608785982840076,0.10369971794157476,0.5628783135395409,-0.15364061243413896,0.27539780900215416,6.0,21.0,27.0,2.0,log_other_mut_burden|lin_Thyroid,False,23.0,0.9794298866052098,1.0339532742795845,92,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.7072060862419872,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,True,18,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=3,n1=18)",,,,,,,,,,,,,,,89,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,89.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.2575342741202116,0.1060958403810624,0.02308090898410273,-0.4765053264774024,-0.03856322176302088,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,1.111295046993353,0.8564169084242784,96,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.07539763601473558,0.3377214937346225,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,True,11,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)",,,,,,,,,,,,,,,89,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,89.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,True,11,PRISM_19Q4_secondary_AUC,TESTED,0.10241351244512537,0.13984766789971936,0.47290993297652584,-0.19029102042188556,0.3951180453121363,6.0,17.0,23.0,2.0,log_other_mut_burden|lin_Thyroid,False,19.0,1.0012989314221132,1.0950351667639253,83,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.6436829643291602,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.08381094638232552,0.03826589967674511,0.03846072450997456,-0.16278788168456187,-0.004834011080089143,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.7548257827202464,0.6921359210740247,97,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.10469863894381962,0.46896670247298183,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=12)",,,,,,,,,,,,,,,65,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,65.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.09231426695639348,0.05023764221959351,0.07854109717149599,-0.19599966447299566,0.011371130560208678,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.9026352945023399,0.7510503833359684,92,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.17493244370015015,0.783558335668724,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=3,n1=17)",,,,,,,,,,,,,,,82,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,82.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)",,,,,,,,,,,,,,,86,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,86.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.006007501054305777,0.06794656797992177,0.9302804189211749,-0.14624232497562684,0.13422732286701528,6.0,22.0,28.0,2.0,log_other_mut_burden|lin_Thyroid,False,24.0,0.7664261633654079,0.7556827939610442,95,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.9302804189211749,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.004511552670644972,0.009692377959915427,0.64209329502745,-0.023622764335658845,0.014599658994368901,172.0,40.0,212.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,202.0,0.6671282769248652,0.6661029001810158,318,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.7865642864086263,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.027566942881536292,0.012396202188557187,0.02718628923825115,-0.0519986872070589,-0.0031351985560136887,186.0,42.0,228.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,218.0,0.6178485363464497,0.5908381443054405,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.08325801079214415,0.3729297263988609,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.055271610176778785,0.017011598469270955,0.0013803850062480316,-0.08883816549474026,-0.02170505485881731,153.0,38.0,191.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,181.0,0.4715494344004954,0.43082271568487546,284,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.006763886530615355,0.030296836655786783,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.02161755553951482,0.029138685566537398,0.45921169209744817,-0.07915030592282504,0.035915194843795406,143.0,32.0,175.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,165.0,0.7022406705609401,0.6717075286369466,255,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.6428963689364274,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.026994492518277104,0.04147626854619655,0.5159694014345975,-0.10883065757393254,0.05484167253737832,157.0,34.0,191.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Uterus,False,182.0,0.7282398309031367,0.6871228752477583,296,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.6653289650077704,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,True,8,PRISM_19Q4_secondary_AUC,TESTED,-0.09875185900944551,0.03401938370097454,0.004081809549508429,-0.16580431847700022,-0.031699399541890785,184.0,42.0,226.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,216.0,0.6999833982662595,0.6195971844626795,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.016548584832620554,0.07412450952407133,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.05314514117878644,0.013355195765793958,9.988105626123782e-05,-0.07949703975342634,-0.026793242604146526,153.0,38.0,191.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,181.0,0.8079357249520625,0.7664636242468199,284,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.0006117714696000817,0.002740250032470323,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.02539981880195419,0.017033899334640612,0.13750195937428855,-0.05898890057365298,0.008189262969744603,170.0,40.0,210.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,200.0,0.41404608677227606,0.38636789009503303,312,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.2564773531033418,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.01277438153136131,0.012116484214185071,0.2930186267763223,-0.03666683099700485,0.011118067934282234,170.0,40.0,210.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,200.0,0.8069763780830287,0.8024517158718085,312,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.4501230372807788,1.0,True,NOT_FDR_SUPPORTED 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Tube|lin_Uterus,False,213.0,0.9028386008260506,0.7538370624294827,330,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,9.958214815818327e-06,4.460488896324462e-05,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.00870896987008303,0.009757335693270102,0.3731165463313033,-0.02794384763820691,0.010525907898040848,179.0,41.0,220.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,210.0,0.582217957058203,0.5772163753537985,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.5377267873598195,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.0438056849247698,0.020966679365034945,0.037879479153284566,-0.08513668450213907,-0.0024746853474005223,180.0,41.0,221.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,211.0,0.8401633972954194,0.8179842000379882,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.10469863894381962,0.46896670247298183,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.08071036408300722,0.01490285123166759,1.662539317436933e-07,-0.11008872420598359,-0.05133200396003084,180.0,40.0,220.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,210.0,0.9109161941036883,0.8378629415109661,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,2.715480885146991e-06,1.216319647688191e-05,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,False,2,PRISM_19Q4_secondary_AUC,TESTED,-0.10756995225192827,0.04210456227853348,0.011315178048398543,-0.19056053381440846,-0.024579370689448085,186.0,39.0,225.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,215.0,1.0365827456977352,0.9543817464390696,331,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.0396031231693949,0.17739052071487135,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.004302021342307895,0.014311104008350391,0.7640005035280713,-0.03250785638997536,0.023903813705359572,186.0,42.0,228.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,218.0,0.77108185246105,0.7795411551803132,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.02389487429180874,0.021719802230393527,0.27249466955053925,-0.06670476677833978,0.0189150181947223,184.0,42.0,226.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,216.0,0.6034508581066104,0.5763959790894456,333,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.4450746269325474,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,0.0023312811757984983,0.019768340954863052,0.9062342267486518,-0.036635358589958096,0.04129792094155509,182.0,41.0,223.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,213.0,1.0231636683744378,1.0353064234890164,324,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.9251141064725821,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,4,PRISM_19Q4_secondary_AUC,TESTED,0.05042339181015042,0.03484350030760861,0.1494313891400722,-0.018286476645994185,0.11913326026629502,172.0,37.0,209.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,199.0,1.1470527568688418,1.179827010267724,298,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.2615049309951264,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,False,6,PRISM_19Q4_secondary_AUC,TESTED,-0.02134036251741895,0.012308261183046669,0.08442390528772421,-0.04560461582101732,0.0029238907861794186,179.0,40.0,219.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,209.0,0.9150017122486291,0.8979669346766752,325,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.17985962430862984,0.8056281893531395,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,True,12,PRISM_19Q4_secondary_AUC,TESTED,-0.008218093153964368,0.012016911499799292,0.49479595805151544,-0.03190539511718067,0.015469208809251934,182.0,41.0,223.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,213.0,0.5928074424442843,0.5963698361580294,331,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.65527032282498,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,False,5,PRISM_19Q4_secondary_AUC,TESTED,-0.03000315966845361,0.010422387043771067,0.004390440873960556,-0.05054470066962469,-0.009461618667282536,186.0,42.0,228.0,8.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,218.0,0.7054322692599972,0.684822773147035,334,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.016548584832620554,0.07412450952407133,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,False,4,PRISM_19Q4_secondary_AUC,TESTED,-0.018788969323724994,0.08065456099181423,0.8163427172121438,-0.17909864269898573,0.14152070405153577,81.0,10.0,91.0,2.0,log_other_mut_burden|lin_Skin,False,87.0,0.8940644820057461,0.9001379603843404,327,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,False,1,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=14,n1=2)",,,,,,,,,,,,,,,239,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,239.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=18,n1=2)",,,,,,,,,,,,,,,338,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,338.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=18,n1=2)",,,,,,,,,,,,,,,326,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,326.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,306,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,306.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,False,3,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,307,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,307.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,True,10,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,273,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,273.0,,,False,NOT_TESTED +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,,,,,,,,,,,,271,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,271.0,,,False,NOT_TESTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,False,1,PRISM_19Q4_secondary_AUC,TESTED,-0.09632427585715136,0.06447190989117807,0.1413242557916373,-0.22575703579594547,0.03310848408164274,27.0,29.0,56.0,3.0,log_other_mut_burden|lin_CNS/Brain|lin_Skin,False,51.0,1.0844214004459474,1.0260946168725,89,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.2564773531033418,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.2436267708867489,0.07101946940459876,0.0011271853230878657,0.10141273646686541,0.38584080530663234,29.0,34.0,63.0,4.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,57.0,0.9901431854794853,1.3197361547703812,91,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.006136897870145046,0.027488425700736167,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,True,19,PRISM_19Q4_secondary_AUC,TESTED,-0.07521611925019966,0.07549519946564621,0.32354644522748743,-0.2265748810164998,0.07614264251610048,26.0,34.0,60.0,4.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,54.0,1.1006767474177737,1.0455070972464928,90,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.480417448974148,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.32352405801683065,0.03815433257946742,6.61194723853692e-12,0.2472297547211868,0.3998183613124745,29.0,38.0,67.0,4.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,61.0,0.6415571202652844,0.9864986275611597,97,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,3.2398541468830907e-10,1.4511971990127463e-09,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,True,19,PRISM_19Q4_secondary_AUC,TESTED,0.05463896840826776,0.2145770388488577,0.7996661797765672,-0.37246594367899943,0.48174388049553496,78.0,5.0,83.0,2.0,log_other_mut_burden|lin_Uterus,False,79.0,1.0695073852141674,1.1102097755033007,290,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.4088092766436812,0.07192656180377399,5.588311396114635e-06,0.2609621114356579,0.5566564418517046,23.0,6.0,29.0,1.0,log_other_mut_burden,False,26.0,0.9418190395057312,1.309917232764145,49,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,4.563787640160285e-05,0.00020442141960807795,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,True,19,PRISM_19Q4_secondary_AUC,TESTED,-0.19959813366378149,0.05628614254836932,0.0016434216253352547,-0.31576702230895065,-0.08342924501861232,21.0,6.0,27.0,1.0,log_other_mut_burden,False,24.0,1.1383798772603528,0.9364634484044408,45,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.007320696331038862,0.0327909020862779,True,FDR_SUPPORTED_DIRECTION_CONSISTENT +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.3295235041665884,0.053482272622677476,8.888825511072926e-07,0.22029813188890043,0.4387488764442763,25.0,9.0,34.0,2.0,log_other_mut_burden|lin_Uterus,False,30.0,0.6357420175607738,0.9637961034254001,55,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,9.958214815818327e-06,4.460488896324462e-05,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.30768660066712955,0.06407399565290699,2.334243784931109e-05,0.17808471144951973,0.43728848988473934,18.0,27.0,45.0,4.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Skin|lin_Uterus,False,39.0,0.9304552564336098,1.2380285078069493,87,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.00016339706494517765,0.0007318890055697993,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,True,19,PRISM_19Q4_secondary_AUC,TESTED,-0.01262960032266958,0.05463645769135126,0.8185016082947978,-0.12343747240132125,0.0981782717559821,16.0,26.0,42.0,4.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Skin|lin_Uterus,False,36.0,1.0083665428875372,0.9998706525738259,85,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,True,NOT_FDR_SUPPORTED +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,False,2,PRISM_19Q4_secondary_AUC,TESTED,0.2963089310054027,0.04100460979648452,6.0613342954445264e-09,0.21361525429645153,0.3790026077143538,18.0,31.0,49.0,4.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Skin|lin_Uterus,False,43.0,0.6422598116998564,0.9412446479274384,95,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,1.4850269023839091e-07,6.651740428720815e-07,False,FDR_SIGNIFICANT_DISCORDANT +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,True,13,PRISM_19Q4_secondary_AUC,TESTED,0.011078445608502512,0.03710126520074646,0.7658296807567118,-0.06247842118448472,0.08463531240148975,104.0,7.0,111.0,3.0,log_other_mut_burden|lin_Lung|lin_Uterus,False,106.0,0.7394748921032596,0.7547556469436044,324,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.8912573068098909,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,True,13,PRISM_19Q4_secondary_AUC,TESTED,0.004680246913723334,0.0314705174118907,0.8820505859700492,-0.05769329548031909,0.06705378930776576,106.0,8.0,114.0,3.0,log_other_mut_burden|lin_Lung|lin_Uterus,False,109.0,0.6924425452437231,0.6969233353221359,331,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,,0.9195846534581363,1.0,False,NOT_FDR_SUPPORTED +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,False,4,PRISM_19Q4_secondary_AUC,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=21,n1=2)",,,,,,,,,,,,,,,96,PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE,96.0,,,False,NOT_TESTED diff --git a/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_inferential_summary.json b/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_inferential_summary.json new file mode 100644 index 0000000000000000000000000000000000000000..eb631d32b0743a0379616bd41ec5e965c8adbca3 --- /dev/null +++ b/results/Therapeutic/06_PRISM_Drug_Response_Statistics/PRISM_inferential_summary.json @@ -0,0 +1,13 @@ +{ + "n_input_rows": 62, + "n_tested": 49, + "n_bh_significant": 14, + "n_bh_direction_consistent": 8, + "n_by_direction_consistent": 5, + "n_distinct_supported_C1_associations": 2, + "assay_independence": "SEPARATE_DRUG_VIABILITY_ASSAY_SAME_GENOTYPE_SOURCE; NOT_INDEPENDENT_COHORT", + "mutation_call_note": "No reported qualifying mutation is NOT proven wild-type", + "model": "OLS(B status + lineage fixed effects + other mutation burden where available), HC3 robust SE", + "hypothesis_family": "All estimable fresh C1-BY-selected target-drug hypotheses", + "q_computed_over": "All available PRISM TESTED gene-pair-drug hypotheses, including direction-discordant tests" +} \ No newline at end of file diff --git a/results/Therapeutic/09_Integrated_Results/All_C1_Drug_Conditional_and_Interaction_Evidence.csv b/results/Therapeutic/09_Integrated_Results/All_C1_Drug_Conditional_and_Interaction_Evidence.csv new file mode 100644 index 0000000000000000000000000000000000000000..c2cc2e16314e078aec549a417711df724e1af935 --- /dev/null +++ b/results/Therapeutic/09_Integrated_Results/All_C1_Drug_Conditional_and_Interaction_Evidence.csv @@ -0,0 +1,63 @@ +A,B,TargetGene,DrugID,conditional_fit_status,conditional_beta_AB_vs_Aonly,conditional_q_global_BH,conditional_q_global_BY,strict_fit_status,strict_beta_AxB_interaction,strict_q_global_BH,strict_q_global_BY,pooled_fit_status,pooled_beta_AxB_interaction,pooled_q_global_BH,pooled_q_global_BY,Bonly_fit_status,Bonly_beta_AB_vs_Bonly,Bonly_q_global_BH,Bonly_q_global_BY,DrugName,DrugTargets,direction_consistent_with_C1,A_symbol,B_symbol,C1_beta,C1_global_BY_q,direct_B_target_flag,multitarget_annotation_flag +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,TESTED,-0.06355575129029015,0.12640121050872263,0.5661769768819717,TESTED,-0.069965297167565,0.7194067979723364,1.0,TESTED,-0.0851965616008882,0.5485348338830978,1.0,TESTED,-0.04678645765697929,0.9944301595699432,1.0,lonafarnib,"FNTA, HRAS, KRAS, NRAS",True,TP53,KRAS,-1.0865308434948422,1.053430644354516e-22,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-A56085258-001-01-8,TESTED,-0.278603797467874,0.2154430158822418,0.9650135068455283,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.16738081672347033,0.5485348338830978,1.0,TESTED,-0.0208908707780976,0.9944301595699432,1.0,LGX818,BRAF,True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K05804044-001-06-0,TESTED,-0.06755832411538915,0.16694066040907615,0.7477614972885734,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.07814731909709721,0.5485348338830978,1.0,TESTED,-0.03504040606320478,0.9944301595699432,1.0,AZ-628,"BRAF, RAF1",True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K05804044-001-18-5,TESTED,-0.11480626283805168,0.26861757618353416,1.0,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.10658792108092549,0.5353658656065486,1.0,TESTED,-0.09743723955892963,0.9944301595699432,1.0,AZ-628,"BRAF, RAF1",True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K09951645-001-06-8,TESTED,-0.2680466571687501,0.1924807670861833,0.8621608794581748,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.046579776875198015,0.8385750120450928,1.0,TESTED,0.023282729872312488,0.9944301595699432,1.0,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K09951645-001-11-8,TESTED,-0.19485059759395473,0.13319065607575037,0.5965882977100995,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.12309709514193794,0.5353658656065486,1.0,TESTED,-0.07792439712376831,0.9944301595699432,1.0,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K16478699-001-09-2,TESTED,-0.042815316735061726,0.4501230372807788,1.0,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.004626603161099729,0.9613265021212019,1.0,TESTED,0.02835739557895264,0.9944301595699432,1.0,PLX-4720,"BRAF, KDR",True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K16730910-001-07-3,TESTED,0.0608785982840076,0.7072060862419872,1.0,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,0.07498107732483437,0.5485348338830978,1.0,TESTED,0.0956389322294939,0.9944301595699432,1.0,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",False,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,True +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K16730910-001-10-7,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=3,n1=18)",,,,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.01817810626610048,0.8385750120450928,1.0,TESTED,-0.050623678398953265,0.9944301595699432,1.0,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",False,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,True +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K20722021-001-02-1,TESTED,-0.2575342741202116,0.07539763601473558,0.3377214937346225,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.08751390736767904,0.5485348338830978,1.0,TESTED,-0.01463801721489948,0.9944301595699432,1.0,CEP-32496,"BRAF, RAF1",True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K23984367-001-07-5,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=19)",,,,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,0.03448466467403422,0.5485348338830978,1.0,TESTED,0.013863275196253522,0.9944301595699432,1.0,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",False,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,True +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K23984367-075-15-2,TESTED,0.10241351244512537,0.6436829643291602,1.0,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,0.09707005583330328,0.6139984934610422,1.0,TESTED,0.1749145378320323,0.9944301595699432,1.0,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",False,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,True +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K31866293-001-01-6,TESTED,-0.08381094638232552,0.10469863894381962,0.46896670247298183,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.03334033520815703,0.6236770412378214,1.0,TESTED,0.0018439503005056208,0.9944301595699432,1.0,TAK-632,BRAF,True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K56343971-001-10-6,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=12)",,,,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.012348941160020457,0.9613265021212019,1.0,TESTED,0.17869713652434432,0.9944301595699432,1.0,vemurafenib,"BRAF, RAF1",False,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K56343971-001-14-8,TESTED,-0.09231426695639348,0.17493244370015015,0.783558335668724,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.05778219317369219,0.5485348338830978,1.0,TESTED,-0.036318850575265654,0.9944301595699432,1.0,vemurafenib,"BRAF, RAF1",True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K67578145-001-09-7,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=3,n1=17)",,,,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.07610298162373758,0.8385750120450928,1.0,TESTED,-0.05334251696445533,0.9944301595699432,1.0,GDC-0879,BRAF,False,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K78809024-001-05-7,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=18)",,,,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.08358820336199137,0.6236770412378214,1.0,TESTED,-0.00573401029880394,0.9944301595699432,1.0,SB-590885,BRAF,False,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7015,ENTREZ:673,BRAF,BRD-K93123848-001-04-1,TESTED,-0.006007501054305777,0.9302804189211749,1.0,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.020237660924336723,0.8653868093911194,1.0,TESTED,-0.024005482022132898,0.9944301595699432,1.0,RAF265,BRAF,True,TERT,BRAF,-1.0910946187228885,8.417418398503914e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K07310275-001-02-5,TESTED,-0.004511552670644972,0.7865642864086263,1.0,TESTED,-0.012645888731947021,0.7418041908051428,1.0,TESTED,0.016981733537663423,0.6236770412378214,1.0,TESTED,0.016756621074001665,0.9944301595699432,1.0,PF-04691502,"MTOR, PIK3CA",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K07955840-001-02-3,TESTED,-0.027566942881536292,0.08325801079214415,0.3729297263988609,TESTED,-0.010212930519727822,0.888972788045726,1.0,TESTED,-0.014198911901667149,0.8385750120450928,1.0,TESTED,-0.029576859727889877,0.9944301595699432,1.0,PF-05212384,"MTOR, PIK3CA",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K07972848-001-02-0,TESTED,-0.055271610176778785,0.006763886530615355,0.030296836655786783,TESTED,-0.07065785861222577,0.3963583300434928,1.0,TESTED,-0.026955409994684206,0.6236770412378214,1.0,TESTED,-0.027244051409367292,0.9944301595699432,1.0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K12184916-001-15-4,TESTED,-0.02161755553951482,0.6428963689364274,1.0,TESTED,-0.018919208687246388,0.8511133389660797,1.0,TESTED,-0.01942590559253307,0.8385750120450928,1.0,TESTED,0.03857491657879045,0.9944301595699432,1.0,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K12184916-001-19-6,TESTED,-0.026994492518277104,0.6653289650077704,1.0,TESTED,-0.03437227791300379,0.8511133389660797,1.0,TESTED,-0.03662253254717874,0.8385750120450928,1.0,TESTED,-0.003398761256202046,0.9944301595699432,1.0,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K23228615-001-02-8,TESTED,-0.09875185900944551,0.016548584832620554,0.07412450952407133,TESTED,-0.13047440401568694,0.3963583300434928,1.0,TESTED,-0.09334673489228026,0.5485348338830978,1.0,TESTED,-0.0528665754736742,0.9944301595699432,1.0,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,True +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K28352084-001-02-3,TESTED,-0.05314514117878644,0.0006117714696000817,0.002740250032470323,TESTED,-0.0692570988523046,0.3963583300434928,1.0,TESTED,-0.0385350437293159,0.5562922254889456,1.0,TESTED,-0.04333760370493518,0.9944301595699432,1.0,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K29415052-050-04-8,TESTED,-0.02539981880195419,0.2564773531033418,1.0,TESTED,-0.04710443977601195,0.3963583300434928,1.0,TESTED,-0.031799107874747684,0.5485348338830978,1.0,TESTED,-0.005396406179219888,0.9944301595699432,1.0,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K42191735-001-05-3,TESTED,-0.01277438153136131,0.4501230372807788,1.0,TESTED,0.025487795022529125,0.7107643672964717,1.0,TESTED,0.023356464391424626,0.6139984934610422,1.0,TESTED,0.02889252833315223,0.9944301595699432,1.0,buparlisib,"PIK3CA, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K43187018-001-03-3,TESTED,0.0035514063092775133,0.9195846534581363,1.0,TESTED,0.038175121712891676,0.5864009860200631,1.0,TESTED,0.02616118340027048,0.6236770412378214,1.0,TESTED,0.03951930865555302,0.9944301595699432,1.0,GDC-0349,PIK3CA,False,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K44844162-001-01-6,TESTED,-0.16922341588870116,9.958214815818327e-06,4.460488896324462e-05,TESTED,-0.0010056087022817044,0.9949638637299998,1.0,TESTED,0.011381564223477738,0.9258342805676718,1.0,TESTED,0.005207464991089893,0.9944301595699432,1.0,taselisib,PIK3CA,True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K49371609-003-03-8,TESTED,-0.00870896987008303,0.5377267873598195,1.0,TESTED,0.0001293682566934966,0.9949638637299998,1.0,TESTED,-3.8458138615685665e-06,0.9997934243733477,1.0,TESTED,0.0019798995766215285,0.9944301595699432,1.0,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K52911425-001-09-8,TESTED,-0.0438056849247698,0.10469863894381962,0.46896670247298183,TESTED,-0.05031249327080605,0.668864296619314,1.0,TESTED,-0.010918679813728783,0.9258342805676718,1.0,TESTED,0.0002629983310577788,0.9944301595699432,1.0,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K54997624-001-06-0,TESTED,-0.08071036408300722,2.715480885146991e-06,1.216319647688191e-05,TESTED,-0.03114175868966075,0.7107643672964717,1.0,TESTED,-0.027622952183123772,0.6236770412378214,1.0,TESTED,-0.02383422207052581,0.9944301595699432,1.0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K56291712-001-01-0,TESTED,-0.10756995225192827,0.0396031231693949,0.17739052071487135,TESTED,-0.10174426458291345,0.4485875873266252,1.0,TESTED,-0.012805546999585846,0.9258342805676718,1.0,TESTED,0.06467211465726078,0.9944301595699432,1.0,voxtalisib,"MTOR, PIK3CA",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K58772419-001-07-0,TESTED,-0.004302021342307895,0.8912573068098909,1.0,TESTED,-0.0009645908893846124,0.9949638637299998,1.0,TESTED,-0.001718955502585451,0.9618179182359965,1.0,TESTED,-0.005307190860076513,0.9944301595699432,1.0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K59317601-001-05-5,TESTED,-0.02389487429180874,0.4450746269325474,1.0,TESTED,-0.015289287154364714,0.9004848819637202,1.0,TESTED,-0.045752996601737775,0.5485348338830978,1.0,TESTED,-0.017944683718208287,0.9944301595699432,1.0,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K60866521-001-07-1,TESTED,0.0023312811757984983,0.9251141064725821,1.0,TESTED,-0.055385489300728216,0.4485875873266252,1.0,TESTED,-0.007687815414653647,0.9258342805676718,1.0,TESTED,-0.0002252171972839806,0.9944301595699432,1.0,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",False,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K64785675-001-04-0,TESTED,0.05042339181015042,0.2615049309951264,1.0,TESTED,0.1008596169913151,0.4485875873266252,1.0,TESTED,0.06833249480737476,0.5485348338830978,1.0,TESTED,0.016791759150140792,0.9944301595699432,1.0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",False,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K67868012-001-07-6,TESTED,-0.02134036251741895,0.17985962430862984,0.8056281893531395,TESTED,-0.047861318854231755,0.3963583300434928,1.0,TESTED,-0.04073646032457721,0.5485348338830978,1.0,TESTED,0.0006952802113979993,0.9944301595699432,1.0,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K81801188-001-02-8,TESTED,-0.008218093153964368,0.65527032282498,1.0,TESTED,-0.014786436736696149,0.7418041908051428,1.0,TESTED,0.006922210373251762,0.9258342805676718,1.0,TESTED,-0.009357365866852421,0.9944301595699432,1.0,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,True +ENTREZ:7157,ENTREZ:5290,PIK3CA,BRD-K98795921-001-01-7,TESTED,-0.03000315966845361,0.016548584832620554,0.07412450952407133,TESTED,-0.03379790741988856,0.4092210197678439,1.0,TESTED,-0.015469185448975551,0.6236770412378214,1.0,TESTED,-0.011006718180141317,0.9944301595699432,1.0,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",True,TP53,PIK3CA,-0.6206702665037973,8.899927369258888e-08,True,False +ENTREZ:7157,ENTREZ:4893,NRAS,BRD-K41599323-001-02-3,TESTED,-0.018788969323724994,0.8912573068098909,1.0,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.04449548273108957,0.9258342805676718,1.0,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=4)",,,,lonafarnib,"FNTA, HRAS, KRAS, NRAS",True,TP53,NRAS,-1.3350632067960593,6.664587881992054e-07,True,False +ENTREZ:7157,ENTREZ:2045,DHFR,BRD-A55424491-001-19-9,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=14,n1=2)",,,,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,methotrexate,DHFR,False,TP53,EPHA7,-0.5396753485849619,4.0947689964442364e-05,False,False +ENTREZ:7157,ENTREZ:2045,DHFR,BRD-A74914197-001-02-9,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=18,n1=2)",,,,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,pralatrexate,"DHFR, TYMS",False,TP53,EPHA7,-0.5396753485849619,4.0947689964442364e-05,False,False +ENTREZ:7157,ENTREZ:2045,DHFR,BRD-K88429204-001-35-1,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=18,n1=2)",,,,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,pyrimethamine,"DHFR, SLC47A1",False,TP53,EPHA7,-0.5396753485849619,4.0947689964442364e-05,False,False +ENTREZ:7157,ENTREZ:55607,MAOB,BRD-K18779551-003-07-8,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,bifemelane,"MAOA, MAOB",False,TP53,PPP1R9A,-0.0731544464992825,0.004497865529228015,False,False +ENTREZ:7157,ENTREZ:55607,MAOB,BRD-K59522102-001-14-6,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,piperine,"MAOA, MAOB, TRPV1",False,TP53,PPP1R9A,-0.0731544464992825,0.004497865529228015,False,False +ENTREZ:7157,ENTREZ:55607,MAOB,BRD-K87024524-065-17-7,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",False,TP53,PPP1R9A,-0.0731544464992825,0.004497865529228015,False,True +ENTREZ:7157,ENTREZ:55607,MAOB,BRD-K88568253-011-19-9,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,iproniazid,"MAOA, MAOB",False,TP53,PPP1R9A,-0.0731544464992825,0.004497865529228015,False,False +ENTREZ:7015,ENTREZ:7157,CDKN1A,BRD-K19669037-001-01-1,TESTED,-0.09632427585715136,0.2564773531033418,1.0,TESTED,-0.11930361389440697,0.502637876828732,1.0,TESTED,-0.08470713509409133,0.5485348338830978,1.0,TESTED,-0.07991442176337735,0.9944301595699432,1.0,GGTI-298,CDKN1A,True,TERT,TP53,-0.3248516515795884,0.04898412473432724,False,False +ENTREZ:7015,ENTREZ:7157,TP53,BRD-A12230535-001-06-7,TESTED,0.2436267708867489,0.006136897870145046,0.027488425700736167,TESTED,0.07893961968505336,0.7107643672964717,1.0,TESTED,0.01354841610101546,0.9258342805676718,1.0,TESTED,0.009531902896789728,0.9944301595699432,1.0,nutlin-3,"MDM2, TP53",False,TERT,TP53,-0.6690480767468656,0.0017146919743462076,True,False +ENTREZ:7015,ENTREZ:7157,TP53,BRD-K11433652-001-17-0,TESTED,-0.07521611925019966,0.480417448974148,1.0,TESTED,0.08277686288834052,0.7107643672964717,1.0,TESTED,-0.03600128495400521,0.8385750120450928,1.0,TESTED,0.03705225816339394,0.9944301595699432,1.0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",True,TERT,TP53,-0.6690480767468656,0.0017146919743462076,True,True +ENTREZ:7015,ENTREZ:7157,TP53,BRD-K62627508-001-01-5,TESTED,0.32352405801683065,3.2398541468830907e-10,1.4511971990127463e-09,TESTED,0.10819948157923687,0.4126685112184149,1.0,TESTED,0.07403376938982592,0.5353658656065486,1.0,TESTED,0.004664108492295024,0.9944301595699432,1.0,idasanutlin,"MDM2, TP53",False,TERT,TP53,-0.6690480767468656,0.0017146919743462076,True,False +ENTREZ:7157,ENTREZ:127255,ASIC3,BRD-K11433652-001-17-0,TESTED,0.05463896840826776,0.8912573068098909,1.0,NO_FULLY_CROSSED_LINEAGE,,,,SPARSE_FOUR_GROUP_ARMS,,,,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",,,,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",False,TP53,LRRIQ3,-0.0915714228989641,0.0029856584920047316,False,True +ENTREZ:673,ENTREZ:7157,TP53,BRD-A12230535-001-06-7,TESTED,0.4088092766436812,4.563787640160285e-05,0.00020442141960807795,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,0.124330557245925,0.5353658656065486,1.0,TESTED,-0.03984843614707069,0.9944301595699432,1.0,nutlin-3,"MDM2, TP53",False,BRAF,TP53,-0.8569077390316492,0.004497865529228015,True,False +ENTREZ:673,ENTREZ:7157,TP53,BRD-K11433652-001-17-0,TESTED,-0.19959813366378149,0.007320696331038862,0.0327909020862779,SPARSE_FOUR_GROUP_ARMS,,,,TESTED,-0.1583834546335783,0.5353658656065486,1.0,TESTED,-0.00834690547666922,0.9944301595699432,1.0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",True,BRAF,TP53,-0.8569077390316492,0.004497865529228015,True,True 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NRAS",False,TERT,NRAS,-1.43378483684841,0.02245943944149391,True,False diff --git a/results/Therapeutic/09_Integrated_Results/C1_Therapeutic_Integrated_Priority_Table.csv b/results/Therapeutic/09_Integrated_Results/C1_Therapeutic_Integrated_Priority_Table.csv new file mode 100644 index 0000000000000000000000000000000000000000..9e0c98f7c4366105b17f8330be6243d31906b919 --- /dev/null +++ b/results/Therapeutic/09_Integrated_Results/C1_Therapeutic_Integrated_Priority_Table.csv @@ -0,0 +1,84 @@ +A,B,A_symbol,B_symbol,gene,TargetGene,C1_beta,C1_global_BY_q,n_PRISM_compounds_target_annotated,n_PRISM_compounds_with_feasible_response,n_direction_consistent_PRISM_fdr_supported,smallest_annotated_target_count,n_drugs_with_clinical_phase_annotations,example_compounds,druggability_evidence,therapeutic_claim,tcga_n_AB_selected_studies,tcga_n_patients_selected_studies,n_pathways_at_BH_05,best_pathway_q,primary_evidence_tier 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a/results/Therapeutic/09_Integrated_Results/Final_Therapeutic_Study_Summary.json b/results/Therapeutic/09_Integrated_Results/Final_Therapeutic_Study_Summary.json new file mode 100644 index 0000000000000000000000000000000000000000..f06a669d494bc50a50b01e8eaa949274fc00e79a --- /dev/null +++ b/results/Therapeutic/09_Integrated_Results/Final_Therapeutic_Study_Summary.json @@ -0,0 +1,16 @@ +{ + "study": "FRESH raw-source drug-response followup", + "n_fresh_C1": 83, + "n_annotated_drug_hypotheses": 62, + "n_PRISM_conditional_tested": 49, + "n_PRISM_BH_concordant": 8, + "n_PRISM_BY_concordant": 5, + "n_strict_interactions_tested": 31, + "n_strict_AxB_BH": 0, + "n_AB_vs_Bonly_tested": 50, + "n_AB_vs_Bonly_BH": 0, + "n_external_independently_validated": 0, + "causal_mechanism_established": false, + "raw_data_only_no_prior_results": true, + "interpretation": "Conditional drug response support differs from A-by-B nonadditive interaction or clinical therapeutic effect" +} \ No newline at end of file diff --git a/results/Therapeutic/10_Verification_And_Figures/Full_Source_And_Status_Audit.json b/results/Therapeutic/10_Verification_And_Figures/Full_Source_And_Status_Audit.json new file mode 100644 index 0000000000000000000000000000000000000000..87f18aa7b11e3746c3b0b3df60e12c18ed3fa76c --- /dev/null +++ b/results/Therapeutic/10_Verification_And_Figures/Full_Source_And_Status_Audit.json @@ -0,0 +1,96 @@ +{ + "stages": { + "PRISM_statistics": { + "status": "ANALYZED", + "n_input_rows": 62, + "n_tested": 49, + "n_bh_significant": 14, + "n_bh_direction_consistent": 8, + "n_by_direction_consistent": 5, + "n_distinct_supported_C1_associations": 2 + }, + "PRISM_lineage_robustness": { + "status": "ANALYZED", + "n_contrasts_with_estimable_refits": 49, + "n_all_estimated_refits_same_direction": 44 + }, + "PRISM_four_group": { + "status": "ATTEMPTED_ALL_NOMINATED_HYPOTHESES", + "n_mapped": 62, + "n_strict": 31 + }, + "druggability": { + "status": "ANNOTATED", + "n_C1": 83, + "n_targetable": 13 + }, + "pathways": { + "status": "ANALYZED", + "n_tests": 7938, + "n_bh_05": 235 + }, + "indirect": { + "status": "ANNOTATION_ONLY_NOT_MEDIATION", + "n_links": 343 + }, + "tcga": { + "status": "PARTIAL_OR_COMPLETE", + "n_studies_computed": 4, + "n_rows": 168 + }, + "GDSC2": { + "status": "DATA_NOT_AVAILABLE", + "reason": "No provider-verified GDSC2 fitted AUC CSV/XLSX and model crosswalk" + }, + "GDSC2_four_group": { + "status": "NOT_TESTED_NO_COMPATIBLE_GDSC2" + }, + "additional_assays": { + "status": "NO_VERIFIED_HARMONIZED_INPUT", + "note": "CTRP and other assays require provider-identifiable model + compound mapping" + }, + "independent_cohort": { + "status": "NOT_AVAILABLE", + "reason": "No externally genotyped, verifiably non-overlapping cohort file" + } + }, + "raw_input_provenance": [ + { + "stage": "genotype_coverage", + "n_models": 2105, + "n_mutation_genes": 43, + "genes_present_damaging": 43, + "genes_present_hotspot": 43, + "calls_undefined": 7568 + }, + { + "source": "mutation_burden", + "measurement": "all common damaging/hotspot gene columns", + "n_candidate_mutation_genes": 530, + "n_models_available": 1929 + }, + { + "source": "PRISM_19Q4_v4", + "provider_article": 9393293, + "provider_version": 4, + "provider_file_id": 20237739, + "checksum": "PROVIDER_VERIFIED", + "source_type": "DOWNLOADED_OFFICIAL_RAW" + }, + { + "stage": "prism_19Q4", + "source": "/kaggle/working/final_comutation_fresh_20261104_192636_UTC/results/Therapeutic/_LOCAL_SOURCE_CACHE/secondary-screen-dose-response-curve-parameters.csv", + "n_assay_rows": 690192, + "n_drugs": 1502, + "n_models": 480, + "n_models_drugs": 644798, + "n_drugs_with_explicit_target": 1210 + }, + { + "source": "GDSC2", + "status": "OFFICIAL_DIRECT_DOWNLOAD_FAILED", + "url": "https://cog.sanger.ac.uk/cancerrxgene/GDSC_data_8.5/GDSC2_fitted_dose_response_27Oct23.xlsx", + "reason": "404 Client Error: Not Found for url: https://cog.sanger.ac.uk/cancerrxgene/GDSC_data_8.5/GDSC2_fitted_dose_response_27Oct23.xlsx" + } + ] +} \ No newline at end of file diff --git a/results/Therapeutic/10_Verification_And_Figures/PRISM_Adjusted_Effect_FDR.png b/results/Therapeutic/10_Verification_And_Figures/PRISM_Adjusted_Effect_FDR.png new file mode 100644 index 0000000000000000000000000000000000000000..61287264688d6d32e6d2edbd190fbec2bd1e997c --- /dev/null +++ b/results/Therapeutic/10_Verification_And_Figures/PRISM_Adjusted_Effect_FDR.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1f2e043935cfe4bcbd8019f05258f2059645246dde4779ffaa0155887c883636 +size 79436 diff --git a/results/Therapeutic/10_Verification_And_Figures/Therapeutic_Evidence_Funnel.png b/results/Therapeutic/10_Verification_And_Figures/Therapeutic_Evidence_Funnel.png new file mode 100644 index 0000000000000000000000000000000000000000..30b062c717fe479ca7c8b774f3a778a92085fb5e --- /dev/null +++ b/results/Therapeutic/10_Verification_And_Figures/Therapeutic_Evidence_Funnel.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:089e879a39b102658109f424c804c9447e85bdb8fd6873011992a683dd103744 +size 62767 diff --git a/results/Therapeutic/10_Verification_And_Figures/run_messages.txt b/results/Therapeutic/10_Verification_And_Figures/run_messages.txt new file mode 100644 index 0000000000000000000000000000000000000000..5927669cf357ea176be23829daaee1c7e7c58432 --- /dev/null +++ b/results/Therapeutic/10_Verification_And_Figures/run_messages.txt @@ -0,0 +1,15 @@ +[2026-11-04T22:13:04.197287+00:00] PRISM_statistics: ANALYZED {'n_input_rows': 62, 'n_tested': 49, 'n_bh_significant': 14, 'n_bh_direction_consistent': 8, 'n_by_direction_consistent': 5, 'n_distinct_supported_C1_associations': 2} +[2026-11-04T22:13:14.028959+00:00] PRISM_lineage_robustness: ANALYZED {'n_contrasts_with_estimable_refits': 49, 'n_all_estimated_refits_same_direction': 44} +[2026-11-04T22:13:18.039260+00:00] PRISM_four_group: ATTEMPTED_ALL_NOMINATED_HYPOTHESES {'n_mapped': 62, 'n_strict': 31} +[2026-11-04T22:13:18.264194+00:00] druggability: ANNOTATED {'n_C1': 83, 'n_targetable': 13} +[2026-11-04T22:15:10.932042+00:00] pathways: ANALYZED {'n_tests': 7938, 'n_bh_05': 235} +[2026-11-04T22:15:11.105180+00:00] indirect: ANNOTATION_ONLY_NOT_MEDIATION {'n_links': 343} +[2026-11-04T22:15:12.430907+00:00] TCGA brca_tcga_pan_can_atlas_2018: 1066 patients; fetched 1925 mutations +[2026-11-04T22:15:13.600999+00:00] TCGA luad_tcga_pan_can_atlas_2018: 566 patients; fetched 3061 mutations +[2026-11-04T22:15:14.769612+00:00] TCGA coadread_tcga_pan_can_atlas_2018: 534 patients; fetched 4036 mutations +[2026-11-04T22:15:16.285188+00:00] TCGA skcm_tcga_pan_can_atlas_2018: 438 patients; fetched 6323 mutations +[2026-11-04T22:15:16.291588+00:00] tcga: PARTIAL_OR_COMPLETE {'n_studies_computed': 4, 'n_rows': 168} +[2026-11-04T22:15:24.003224+00:00] GDSC2: DATA_NOT_AVAILABLE {'reason': 'No provider-verified GDSC2 fitted AUC CSV/XLSX and model crosswalk'} +[2026-11-04T22:15:24.008431+00:00] GDSC2_four_group: NOT_TESTED_NO_COMPATIBLE_GDSC2 {} +[2026-11-04T22:15:24.011609+00:00] additional_assays: NO_VERIFIED_HARMONIZED_INPUT {'note': 'CTRP and other assays require provider-identifiable model + compound mapping'} +[2026-11-04T22:15:24.013470+00:00] independent_cohort: NOT_AVAILABLE {'reason': 'No externally genotyped, verifiably non-overlapping cohort file'} diff --git a/results/Therapeutic/10_Verification_And_Figures/stage_status.json b/results/Therapeutic/10_Verification_And_Figures/stage_status.json new file mode 100644 index 0000000000000000000000000000000000000000..a5e268a3890573bd79d46986703ccfe8e4e9cd73 --- /dev/null +++ b/results/Therapeutic/10_Verification_And_Figures/stage_status.json @@ -0,0 +1,55 @@ +{ + "PRISM_statistics": { + "status": "ANALYZED", + "n_input_rows": 62, + "n_tested": 49, + "n_bh_significant": 14, + "n_bh_direction_consistent": 8, + "n_by_direction_consistent": 5, + "n_distinct_supported_C1_associations": 2 + }, + "PRISM_lineage_robustness": { + "status": "ANALYZED", + "n_contrasts_with_estimable_refits": 49, + "n_all_estimated_refits_same_direction": 44 + }, + "PRISM_four_group": { + "status": "ATTEMPTED_ALL_NOMINATED_HYPOTHESES", + "n_mapped": 62, + "n_strict": 31 + }, + "druggability": { + "status": "ANNOTATED", + "n_C1": 83, + "n_targetable": 13 + }, + "pathways": { + "status": "ANALYZED", + "n_tests": 7938, + "n_bh_05": 235 + }, + "indirect": { + "status": "ANNOTATION_ONLY_NOT_MEDIATION", + "n_links": 343 + }, + "tcga": { + "status": "PARTIAL_OR_COMPLETE", + "n_studies_computed": 4, + "n_rows": 168 + }, + "GDSC2": { + "status": "DATA_NOT_AVAILABLE", + "reason": "No provider-verified GDSC2 fitted AUC CSV/XLSX and model crosswalk" + }, + "GDSC2_four_group": { + "status": "NOT_TESTED_NO_COMPATIBLE_GDSC2" + }, + "additional_assays": { + "status": "NO_VERIFIED_HARMONIZED_INPUT", + "note": "CTRP and other assays require provider-identifiable model + compound mapping" + }, + "independent_cohort": { + "status": "NOT_AVAILABLE", + "reason": "No externally genotyped, verifiably non-overlapping cohort file" + } +} \ No newline at end of file diff --git a/results/Therapeutic/12_PRISM_Four_Group_Interaction/Four_Group_Eligibility_Summary.png b/results/Therapeutic/12_PRISM_Four_Group_Interaction/Four_Group_Eligibility_Summary.png new file mode 100644 index 0000000000000000000000000000000000000000..eb74f454742a45a10fcfad818f85d1d7e6fad20f --- /dev/null +++ b/results/Therapeutic/12_PRISM_Four_Group_Interaction/Four_Group_Eligibility_Summary.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:35fbd73503243425bfb2ebc1dcdf95da9c0afb0a8cab3d0bd177a960925c0e83 +size 62763 diff --git a/results/Therapeutic/12_PRISM_Four_Group_Interaction/Four_Group_Interaction_Results_Summary.json b/results/Therapeutic/12_PRISM_Four_Group_Interaction/Four_Group_Interaction_Results_Summary.json new file mode 100644 index 0000000000000000000000000000000000000000..ff7644d926b80743fca60b7858b2f79065b60907 --- /dev/null +++ b/results/Therapeutic/12_PRISM_Four_Group_Interaction/Four_Group_Interaction_Results_Summary.json @@ -0,0 +1,28 @@ +{ + "status": "FOUR_GROUP_STATISTICAL_ANALYSIS_COMPLETED", + "original_run": "FRESH_STANDALONE", + "all_target_drug_hypotheses_mapped": 62, + "prior_original_PRISM_tested": 49, + "n_strict_four_group_tested": 31, + "n_strict_AxB_BH_005": 0, + "n_strict_AxB_BY_005": 0, + "n_strict_AxB_BH_005_negative": 0, + "n_exploratory_pooled_tested": 51, + "n_exploratory_AxB_BH_005": 0, + "n_exploratory_AxB_BY_005": 0, + "n_Bonly_vs_AB_tested": 50, + "n_Bonly_vs_AB_BH_005": 0, + "n_Bonly_vs_AB_BY_005": 0, + "n_Bonly_vs_AB_BH_005_increased_sensitivity": 0, + "key_limitations": [ + "Observational PRISM drug-response statistics, no causal synthetic lethality.", + "No independent biological cohort validation, no new wet-lab intervention.", + "A/B mutation absence means no *reported qualifying* mutation, not validated wild type.", + "Exploratory partially crossed pooled analysis never promoted to strict primary.", + "A mutation and B mutation may affect target kinase status directly; drug targets are annotations and some compounds are multi-target.", + "Post-discovery target-drug tests require selection-aware and across-assay interpretation." + ], + "independent_cohort_validated_findings": 0, + "original_main_C1_counts_unchanged": true, + "original_PRISM_results_unchanged": true +} \ No newline at end of file diff --git a/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_AB_vs_Bonly_HC3_BH_BY.csv b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_AB_vs_Bonly_HC3_BH_BY.csv new file mode 100644 index 0000000000000000000000000000000000000000..1fe9fa2cee0263f10a7292237e7eb8e0b3643cbd --- /dev/null +++ b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_AB_vs_Bonly_HC3_BH_BY.csv @@ -0,0 +1,63 @@ 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PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.029576859727889877,0.021356619470641616,0.17177724292063198,-0.07239430377029304,0.013240584314513283,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,41,-0.027244051409367292,0.02728968034670358,0.3234585739096675,-0.082208289077138,0.027720186258403414,21.0,32.0,6.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,19,34,0.03857491657879045,0.03790992200831928,0.3160823483465395,-0.038467314271279335,0.11561714742886023,16.0,26.0,6.0,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,24,37,-0.003398761256202046,0.07048631514193959,0.961770483822092,-0.14564590414324496,0.1388483816308409,19.0,31.0,6.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.0528665754736742,0.05114156701605674,0.3058698458031309,-0.15539924394964785,0.04966609300229944,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,41,-0.04333760370493518,0.03413353689819519,0.21073654203634132,-0.11208607604607952,0.025410868636209158,21.0,32.0,6.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,43,-0.005396406179219888,0.02196617880365997,0.8069859989910774,-0.049562368774047294,0.03876955641560752,20.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,23,43,0.02889252833315223,0.020463558264676825,0.16442919725837893,-0.012252213178475607,0.07003726984478006,20.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,44,0.03951930865555302,0.03250420423947355,0.22944071170651756,-0.025675868828765144,0.10471448613987118,24.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,44,0.005207464991089893,0.04740034963453943,0.9129342943242722,-0.08986559646505438,0.10028052644723415,24.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,26,44,0.0019798995766215285,0.014840432957856073,0.8943821200007238,-0.027799607803992536,0.03175940695723559,23.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,44,0.0002629983310577788,0.03749714787079176,0.9944301595699432,-0.07494675584662475,0.0754727525087403,24.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,25,43,-0.02383422207052581,0.0298862446223082,0.42893300789024114,-0.08386251103313531,0.036194066892083696,22.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,26,42,0.06467211465726078,0.05726896966795195,0.26417291628215506,-0.0503559962099262,0.17970022552444775,23.0,36.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.005307190860076513,0.026086239757762558,0.8395496851708368,-0.0576069526571225,0.04699257093696947,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.017944683718208287,0.03331771340892108,0.5923812108528816,-0.08474267726153967,0.04885330982512309,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,25,44,-0.0002252171972839806,0.030550874611264427,0.9941469101028874,-0.06155865723581257,0.061108222841244605,22.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,26,39,0.016791759150140792,0.04677270100659654,0.7211317337949654,-0.07720150256636549,0.11078502086664707,23.0,35.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,6,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,25,43,0.0006952802113979993,0.02285612275719545,0.9758509348424373,-0.045190300888294024,0.04658086131109003,23.0,37.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,26,44,-0.009357365866852421,0.016406492450829605,0.57089985246891,-0.04227940152557835,0.023564669791873508,23.0,38.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,27,45,-0.011006718180141317,0.01563416232191564,0.48444707717673685,-0.04235132640752008,0.020337890047237447,24.0,39.0,7.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=2,n1=4)",9,13,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,4,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,6,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,6,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,2,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,3,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,2,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,2,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,262,55,-0.07991442176337735,0.03898291669779807,0.041732285165870825,-0.15680674319993265,-0.0030221003268220414,151.0,51.0,9.0,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,251,53,0.009531902896789728,0.04579466542472409,0.8353515508428239,-0.08083154245134616,0.09989534824492563,142.0,49.0,9.0,log_other_mut_burden|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Skin|lin_Thyroid,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, 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Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,267,71,0.009868865169738013,0.019373442218148556,0.6109486599310505,-0.02829894828498626,0.04803667862446229,182.0,65.0,10.0,log_other_mut_burden|lin_Esophagus/Stomach|lin_Head and Neck|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,0.9944301595699432,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,10,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=0,n1=0)",2,11,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,"SPARSE_AFTER_LINEAGE_OVERLAP(n0=4,n1=2)",18,4,,,,,,,,,,,,NOT_ESTIMABLE,False diff --git a/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Arm_Counts_By_Lineage.csv b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Arm_Counts_By_Lineage.csv new file mode 100644 index 0000000000000000000000000000000000000000..109aeb52405b292ee81e1a51d5ad415c1f610e07 --- /dev/null +++ b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Arm_Counts_By_Lineage.csv @@ -0,0 +1,1358 @@ +A,B,TargetGene,DrugID,Dataset,Lineage,n00,n01,n10,n11 +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Ampulla of Vater,0,1,0,0 +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Biliary Tract,1,0,3,1 +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Bladder/Urinary Tract,5,0,17,0 +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Bone,6,0,4,0 +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Bowel,2,4,7,13 +ENTREZ:7157,ENTREZ:3845,KRAS,BRD-K41599323-001-02-3,PRISM_19Q4_secondary_AUC,Breast,5,0,15,2 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KDR",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,341,32,73,22,254,29,69,22,13,1,374.0,-0.017377508862216746,-0.0631567348197741,-0.004626603161099729,0.04080649450397523,0.9097937479794753,-0.08487792859339109,0.07562472227119164,-0.06778333798087383,0.14674317689753133,-0.022004112023316473,0.5589240050507245,0.8982523953944085,0.8319248644607429,0.8982007184596306,0.8185479453707852,357.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9613265021212019,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,332,32,71,21,248,29,67,21,13,1,365.0,0.045542903728094546,-0.06833876575445202,0.07498107732483437,0.05875605968815773,0.2027563560729175,-0.04058058899950155,0.1905427436491703,0.00664231157038235,0.9146695782553849,0.12052398105292891,0.022188166723654864,1.0309807745431732,0.9492998451590773,1.0836394720881928,1.0339532742795845,348.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,311,30,68,21,234,28,64,21,13,1,347.0,0.004813893579834624,8.938700845778982e-06,-0.01817810626610048,0.030446030199124317,0.5508767498162885,-0.07807088760470919,0.04171467507250823,-0.018169167565254704,0.5404716906799454,-0.013364212686265857,0.6093680096007699,0.9064701497200481,0.9001744951425368,0.9145912958711789,0.8680422038945185,330.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,311,30,74,22,231,27,70,22,13,1,350.0,0.05812360289417023,-0.1043299314655402,-0.08751390736767904,0.06881478676799384,0.20435611458389916,-0.22288039962569128,0.047852584890333186,-0.19184383883321926,0.0015348370944802217,-0.029390304473508815,0.6375421414910185,1.0311478746882898,0.9249392415724274,1.0880637911968536,0.8564169084242784,333.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,321,30,67,22,203,28,62,22,12,1,315.0,-0.0252150747149236,0.01452155810160316,0.03448466467403422,0.024671171308809987,0.1632177719319449,-0.014066465315167066,0.08303579466323552,0.04900622277563738,0.043495756262490956,0.009269589959110622,0.65610471410287,0.9415026082543605,0.963127924399852,0.9287046375728254,0.9614220211951024,299.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,318,28,66,17,203,26,61,17,12,1,307.0,0.04601373077058385,-0.04215380277534623,0.09707005583330328,0.08689269298141306,0.2648620952184888,-0.0739477591254254,0.26808787079203195,0.05491625305795705,0.5133776397658087,0.14308378660388713,0.06700097551276507,0.9738465099817348,0.9671730808246544,1.031160052652526,1.095035166763925,291.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6139984934610422,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,319,30,75,22,236,27,71,22,13,1,356.0,-0.005929118756920593,-0.026487981566249014,-0.03334033520815703,0.03213659205939696,0.3002623144137365,-0.09655257668653804,0.029871906270223972,-0.059828316774406046,0.03453315831118815,-0.039269453965077625,0.19790236786092733,0.7816684224646426,0.7412608268306835,0.7892403535070749,0.6921359210740247,339.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,255,23,51,14,159,21,47,14,11,1,241.0,0.03232881550969509,-0.23125331195804733,-0.012348941160020457,0.12361436159560284,0.9205131335889929,-0.255933048512911,0.2312351661928701,-0.24360225311806777,0.03313147416582631,0.01997987434967463,0.8603018385950916,1.1921037753381845,0.9773413008462216,1.214291258788444,0.9545493481182031,226.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9613265021212019,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,311,28,70,22,231,26,66,22,13,1,345.0,-0.01182128790980092,-0.09843322233086546,-0.05778219317369219,0.038484199004979826,0.13420062603410451,-0.13348918792148545,0.01792480157410107,-0.15621541550455764,2.918618298224803e-06,-0.06960348108349311,0.0619558540236259,0.9547269343974983,0.8435588491251861,0.9381343680605845,0.7510503833359684,328.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,295,25,62,20,221,23,59,20,13,1,323.0,0.027509597041678026,-0.2653525319706356,-0.07610298162373758,0.13893627802085406,0.5842597513980103,-0.34949438943206346,0.1972884261845883,-0.34145551359437315,0.011781266128720172,-0.04859338458205955,0.6821753839184475,1.4230170860900317,1.1015586603520833,1.4871805901858086,0.9488074257802385,306.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,313,31,65,21,240,28,63,21,13,1,352.0,0.03919932898486207,-0.09813780674393352,-0.08358820336199137,0.08467220800943882,0.32425822935645765,-0.25014441519256186,0.08296800846857912,-0.18172601010592487,0.03268545481603373,-0.044388874377129295,0.5435909429846151,1.1696511793557225,1.0272354543001396,1.2182969788592453,0.9189134073195058,335.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,335,31,73,22,249,28,69,22,13,1,368.0,-0.007875622972244839,-0.01860541750180761,-0.020237660924336723,0.046220832662226964,0.6617663836520324,-0.11114227838606947,0.07066695653739602,-0.03884307842614433,0.3644768850675628,-0.028113283896581562,0.45405360167292874,0.8848205435044063,0.8336170317074089,0.8855301296721699,0.7556827939610443,351.0,log_other_mut_burden|lin_Bowel|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8653868093911194,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,104,25,275,43,94,24,259,41,16,6,418.0,-0.003466384072166537,-0.01621948920786006,0.016981733537663423,0.016135116301885293,0.293222306716844,-0.014738974502491103,0.048702441577817945,0.0007622443298033639,0.9345708591331195,0.013515349465496887,0.3087548355813809,0.6651147314747584,0.6554962120213711,0.6645339619629823,0.664539634127245,398.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,101,26,272,43,15,7,442.0,-0.009242405075439252,-0.018483916733601623,-0.014198911901667149,0.02234658305454393,0.5255142600113653,-0.05812308737193703,0.029725263568602733,-0.03268282863526877,0.011318598502699643,-0.0234413169771064,0.2460706491662893,0.6459542240873574,0.6156595986427251,0.6251037315303961,0.5883066902607604,423.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,95,23,243,41,85,23,224,39,14,6,371.0,0.0239671256339935,-0.023882830833323224,-0.026955409994684206,0.029077423978594634,0.3545485163717058,-0.08414218352797487,0.03023136353860646,-0.05083824082800743,0.0021684463626642472,-0.0029882843606907072,0.9042995621169854,0.46931006720696467,0.4357888445110958,0.47702414390129194,0.4291179510450638,353.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,97,19,221,34,85,18,206,33,15,6,342.0,0.04774895661758885,0.001467109995094224,-0.01942590559253307,0.035740766905248786,0.5871451270070032,-0.08973998895852195,0.050888177773455806,-0.017958795597438848,0.48704883810629196,0.02832305102505578,0.37553963546944324,0.676585665541435,0.657322455863646,0.7081638910334072,0.6724435115480358,323.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,106,24,259,37,95,23,245,36,16,6,399.0,0.029530289362616393,0.01974082028186278,-0.03662253254717874,0.0603016340709392,0.5440006650036537,-0.15519019674427337,0.08194513164991588,-0.01688171226531596,0.6455921339034869,-0.007092243184562346,0.8946477601940594,0.666085752862219,0.7055121284018141,0.7187909206714768,0.6802149687232648,379.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,104,26,273,43,16,7,446.0,0.024319469408280156,0.009379840972960747,-0.09334673489228026,0.052463828053137984,0.07591022043538255,-0.19646692201392532,0.009773452229364793,-0.08396689391931952,0.009251046846988369,-0.06902726548400011,0.13241462077557561,0.6789774309435492,0.6888124287916634,0.6982660829507081,0.6169092388059537,426.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,95,23,243,41,85,23,224,39,14,6,371.0,0.002402777876994916,-0.011878267915093466,-0.0385350437293159,0.031236589190275197,0.2181538139172336,-0.09996826261733374,0.022898175158701954,-0.05041331164440936,0.00020844058612422988,-0.03613226585232098,0.18488053583363231,0.8233273337085785,0.8041056496765926,0.8143737579122192,0.7637067276141696,353.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5562922254889456,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,23,269,43,101,22,255,41,16,7,419.0,0.024991049773801708,0.010611338706961298,-0.031799107874747684,0.021421139179824474,0.13847297079774534,-0.0739115100980833,0.010313294348587937,-0.021187769167786384,0.17151872555049882,-0.006808058100945976,0.7194601693486264,0.39752957296640845,0.3962991371416434,0.4152097580162664,0.3843112336025716,399.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,23,269,43,101,22,255,41,16,7,419.0,0.005465226069926806,-0.030363100281863318,0.023356464391424626,0.02049757069824975,0.2551887920473158,-0.01694026934433111,0.06365319812718036,-0.007006635890438692,0.5521160966736767,0.028821690461351433,0.10421347254260524,0.8089111817219996,0.7764677346809458,0.8114223518371335,0.8000496913231202,399.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6139984934610422,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,110,27,287,44,100,26,271,42,16,7,439.0,0.013956379979324071,-0.020522181746168728,0.02616118340027048,0.028231892952361656,0.3546398861940553,-0.029332606652814404,0.08165497345335537,0.005639001654101753,0.792072949224875,0.04011756337959455,0.12193832295486609,0.6775167989538977,0.6598408608663351,0.6900415334018837,0.6944524982533983,419.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,109,27,286,44,100,26,270,42,16,7,438.0,-0.011965045227520526,-0.17403738453758316,0.011381564223477738,0.05463017516926703,0.8350662138453511,-0.09600253807828757,0.11876566652524304,-0.16265582031410541,7.091892246715869e-07,-0.0005834810040427872,0.9887977479187899,0.973154605314344,0.7692279672618644,0.9180997033931538,0.751352665874827,418.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,26,283,44,101,25,267,42,16,7,435.0,0.010043310927727724,-0.0052799375792580375,-3.8458138615685665e-06,0.01484525340340648,0.9997934243733477,-0.02918511181085163,0.029177420183128494,-0.0052837833931196065,0.5753108883396496,0.010039465113866155,0.43655325505525056,0.582129187740091,0.5712166444623169,0.5851339752074395,0.5795838906462085,415.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9997934243733477,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,113,27,283,44,103,26,268,42,16,7,439.0,0.023788812525049878,-0.02385079653183924,-0.010918679813728783,0.039796846985186776,0.7839428681072297,-0.08914502740923974,0.06730766778178218,-0.034769476345568026,0.08448923478940971,0.012870132711321095,0.6930413635960269,0.8323840273004508,0.8134518734374047,0.8469043690438333,0.8157826067412535,419.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,25,284,43,101,24,268,41,16,7,434.0,0.003026978037660342,-0.051459422887598485,-0.027622952183123772,0.028325999746166248,0.33004036687437277,-0.08330367048143356,0.028057766115186004,-0.07908237507072226,2.3870445736875194e-07,-0.02459597414546343,0.3273561311707791,0.9221648041081577,0.8742427704908765,0.9181818907580286,0.8376903576458784,414.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,109,26,289,42,99,25,274,40,16,7,438.0,0.05569997342599555,-0.07383289967337367,-0.012805546999585846,0.05926257088573977,0.829029602670899,-0.12929534325123643,0.10368424925206474,-0.08663844667295952,0.025361891484898456,0.042894426426409706,0.36238219260590543,0.9947434910264914,0.9128651564379914,1.0403515528428926,0.9501588997016451,418.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,101,26,272,43,15,7,442.0,-0.001406033557020201,0.004616330484701919,-0.001718955502585451,0.024009724462777847,0.942958743368624,-0.048912181765490226,0.04547427076031932,0.0028973749821164683,0.8378413454613861,-0.003124989059605652,0.8867908291070015,0.7695820167737809,0.7803433807340912,0.7711148696591511,0.779643178310328,423.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9618179182359965,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,288,45,104,26,272,43,16,7,445.0,0.023727846897180015,0.024057747658659718,-0.045752996601737775,0.035620702861477276,0.19968437864419747,-0.11576767728277884,0.024261684079303292,-0.021695248943078057,0.2745953701385982,-0.02202514970455776,0.4667198603613152,0.5823341997482866,0.6092609689912821,0.6114017307806489,0.5743803911822646,425.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,109,25,280,44,99,24,264,42,16,7,429.0,0.01315021190726561,0.01910239718472619,-0.007687815414653647,0.031501585436436864,0.807318069449751,-0.0696130357062225,0.0542374048769152,0.011414581770072542,0.554403067633949,0.005462396492611963,0.8435572427370099,1.0027582023272328,1.027620205292683,1.0208313303657994,1.0363442741253874,409.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,100,26,259,39,89,25,243,38,15,7,395.0,-0.03376109450960487,-0.023342005976489895,0.06833249480737476,0.05139965097079557,0.18451052056166975,-0.0327342908786092,0.16939928049335873,0.04499048883088486,0.21498617765551833,0.03457140029776989,0.4514362142293399,1.1969180078911703,1.1656659560021274,1.1555070545294235,1.1899888097290405,376.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,6,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,107,25,282,43,98,24,267,41,16,7,430.0,0.02803499687128947,0.034308316225099444,-0.04073646032457721,0.02604330509102342,0.11854639456851782,-0.09193152586775413,0.01045860521859971,-0.006428144099477763,0.63124993676063,-0.012701463453287737,0.5950227114795352,0.9050124356077371,0.9131538210351029,0.9188995358213182,0.9052719624519847,410.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,111,26,287,44,100,25,271,42,16,7,438.0,-0.010362791285284733,-0.008373312860676219,0.006922210373251762,0.020086645028944975,0.7305552303490923,-0.03256121317434315,0.04640563392084667,-0.0014511024874244568,0.896486269576213,-0.0034405809120329712,0.8410635723438074,0.6102484158383732,0.5955046282673064,0.5956978573297165,0.5957568409256973,418.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,115,27,289,45,101,26,272,43,15,7,442.0,0.011664366135287952,-0.013615193435277291,-0.015469185448975551,0.0162480639382876,0.34160856527994266,-0.04740618493276863,0.01646781403481753,-0.029084378884252842,0.0034391391315521684,-0.0038048193136875994,0.7830967139481572,0.6898895178819843,0.6857259559943203,0.7035821786445339,0.6834803797423844,423.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.6236770412378214,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,126,9,314,13,112,7,293,11,14,1,423.0,0.03662045135618014,0.06186244511615367,-0.04449548273108957,0.14348080756926077,0.7566333792340211,-0.32655560561437963,0.23756464015220052,0.017366962385064105,0.8456342357233204,-0.007875031374909428,0.9547673915630248,0.9230013169192518,0.9803609230647188,0.9189812208037236,0.9511160720314613,405.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,97,2,235,4,89,2,220,4,14,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,139,2,332,6,127,2,315,5,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,137,2,320,6,126,2,303,5,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,131,2,304,2,119,2,286,2,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,132,2,304,3,117,2,286,3,15,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,117,2,271,2,105,2,256,2,15,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,111,2,269,2,99,2,230,1,14,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,96,262,34,55,86,254,34,54,17,3,428.0,0.007831318402705907,0.03048698831077705,-0.08470713509409133,0.05329232143486983,0.1127282828701595,-0.1894696995197337,0.02005542933155101,-0.054220146783314285,0.26504440132250817,-0.07687581669138543,0.02897424435440099,1.0494586785179019,1.0867278194188368,1.0719237019306294,1.0244539162036603,407.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5485348338830978,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,98,251,38,53,89,243,37,52,17,4,421.0,0.0003732801532880989,0.25264690762267583,0.01354841610101546,0.060855667794808194,0.8239356017214353,-0.10608849237226531,0.13318532457429622,0.2661953237236913,1.4346526005012066e-06,0.01392169625430356,0.7326638067599123,1.0056547456771872,1.2625120069218856,1.006929581215757,1.2958208046612256,400.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9258342805676718,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,87,235,35,55,78,222,34,53,16,4,387.0,0.03492342964795162,0.020187745968509252,-0.03600128495400521,0.06649505612880303,0.5885514831043521,-0.16676041801344882,0.09475784810543841,-0.015813538985495958,0.7969822118474461,-0.0010778553060535878,0.9791474474121108,1.0157877014155823,1.040785909358323,1.0839071390241586,1.0379137266750658,367.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,103,279,38,59,93,270,37,58,17,4,458.0,-0.05214247177992677,0.24669392852137864,0.07403376938982592,0.037708467868363016,0.050242800826167305,-7.872988890049448e-05,0.14814626866855235,0.3207276979112046,2.390867335799099e-22,0.02189129760989915,0.32599439699958477,0.7043850891405173,0.9477316810177814,0.6473886088587106,0.9689300737500407,437.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,19,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,120,2,282,8,109,2,260,7,15,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,108,283,28,21,98,275,28,20,17,1,421.0,-0.13380918939804787,0.23676370337402441,0.124330557245925,0.058558963774190204,0.03435318793096766,0.009208767555521705,0.23945234693632828,0.3610942606199494,2.3619389253670736e-12,-0.00947863215212287,0.8484899179609208,1.0289240777161182,1.269876493021443,0.9258966876454668,1.247853197175257,400.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,99,268,23,22,89,255,23,20,16,1,387.0,0.14545223787823744,0.03080647479751673,-0.1583834546335783,0.07194876846700224,0.02833412314597591,-0.29986703457396263,-0.016899874693193984,-0.1275769798360616,0.04905031556048347,-0.012931216755340869,0.8319640254110583,1.0100527859442476,1.0418129340769993,1.1386776299216854,1.0200800600845672,367.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,113,311,28,27,102,302,28,26,17,2,458.0,-0.07940297637131377,0.2518998445038468,0.08449644689432471,0.04532935785220292,0.06298421948312337,-0.004594205445466584,0.17358709923411603,0.3363962913981715,6.326440642913208e-16,0.005093470523010943,0.8390878783327778,0.7026282223701156,0.9505010632077114,0.6354683262888795,0.9628529639836331,437.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Peripheral Nervous System|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5353658656065486,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,112,241,24,63,100,233,23,60,16,2,416.0,0.07222802594411089,0.26495211617101805,-0.03485165473858358,0.06813283115253334,0.6092685062563209,-0.16879893452193984,0.09909562504477269,0.23010046143243446,0.0003102605350774541,0.03737637120552731,0.30776990949586364,0.9971495488681004,1.2676557944832247,1.0200233026084855,1.269919703095434,396.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,100,227,22,63,89,218,21,60,16,3,388.0,-0.04565077052066448,0.004975524853015924,0.029085521552697266,0.05642877382874345,0.6065566379920526,-0.0818777836661532,0.14004882677154773,0.03406104640571319,0.48809475690528614,-0.01656524896796721,0.6500274169656859,1.044010219988574,1.041530794793782,0.9985146102406497,1.0352124021187386,368.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8385750120450928,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,pooled,117,267,24,71,104,258,23,68,16,3,453.0,0.0033245833077787733,0.2647781908984173,0.003799426284185578,0.03960981266704317,0.923627423606645,-0.07405198726452748,0.08165083983289863,0.26857761718260287,1.295206190812562e-13,0.007124009591964351,0.7087070848276942,0.6889891831899823,0.9532105164194745,0.6744706218872455,0.9453367251769931,433.0,log_other_mut_burden|lin_Bone|lin_Bowel|lin_Breast|lin_CNS/Brain|lin_Esophagus/Stomach|lin_Head and Neck|lin_Kidney|lin_Liver|lin_Lung|lin_Ovary/Fallopian Tube|lin_Pancreas|lin_Skin|lin_Soft Tissue|lin_Thyroid|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9613265021212019,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,135,2,314,10,124,2,297,10,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,135,2,320,11,123,2,302,11,16,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,pooled,348,18,92,4,219,16,86,4,11,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False diff --git a/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Raw_Arm_Counts.csv b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Raw_Arm_Counts.csv new file mode 100644 index 0000000000000000000000000000000000000000..9bb50b5d31962e5381d955aae335a030993a9522 --- /dev/null +++ b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Raw_Arm_Counts.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,DrugID,DrugName,DrugTargets,C1_beta,C1_global_BY_q,NAnnotatedTargets,MultitargetFlag,Dataset,target_equals_A,target_equals_B,response_scale,n00,n01,n10,n11,n_models_with_both_known_genotype_calls,n_lineages +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.0865308434948422,1.053430644354516e-22,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,23,256,71,462,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-A56085258-001-01-8,LGX818,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,309,32,72,21,434,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,322,31,72,21,446,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,301,31,67,20,419,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,299,27,67,20,413,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,315,28,63,21,427,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,341,32,73,22,468,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,332,32,71,21,456,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,311,30,68,21,430,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,311,30,74,22,437,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,321,30,67,22,440,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,318,28,66,17,429,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,319,30,75,22,446,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,255,23,51,14,343,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,311,28,70,22,431,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,295,25,62,20,402,21 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,313,31,65,21,430,22 +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,335,31,73,22,461,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,104,25,275,43,447,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,95,23,243,41,402,21 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,97,19,221,34,371,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,106,24,259,37,426,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,95,23,243,41,402,21 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,23,269,43,447,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,23,269,43,447,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,110,27,287,44,468,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,109,27,286,44,466,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,26,283,44,465,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,113,27,283,44,467,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,25,284,43,464,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,109,26,289,42,466,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,288,45,475,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,109,25,280,44,458,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,100,26,259,39,424,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,6,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,107,25,282,43,457,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,111,26,287,44,468,22 +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,115,27,289,45,476,22 +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,126,9,314,13,462,22 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,97,2,235,4,338,21 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,139,2,332,6,479,22 +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,137,2,320,6,465,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,131,2,304,2,439,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,132,2,304,3,441,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,117,2,271,2,392,22 +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,111,2,269,2,384,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,96,262,34,55,447,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,98,251,38,53,440,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,87,235,35,55,412,22 +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,103,279,38,59,479,22 +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,19,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,120,2,282,8,412,22 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,108,283,28,21,440,22 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,99,268,23,22,412,22 +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,113,311,28,27,479,22 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,112,241,24,63,440,22 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,100,227,22,63,412,22 +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,117,267,24,71,479,22 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,135,2,314,10,461,22 +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,135,2,320,11,468,22 +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,348,18,92,4,462,22 diff --git a/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Strict_Interaction_HC3_BH_BY.csv b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Strict_Interaction_HC3_BH_BY.csv new file mode 100644 index 0000000000000000000000000000000000000000..a3993ebc3903c94faf5780a1652382fc850f25f5 --- /dev/null +++ b/results/Therapeutic/12_PRISM_Four_Group_Interaction/PRISM_Four_Group_Strict_Interaction_HC3_BH_BY.csv @@ -0,0 +1,63 @@ +A,B,A_symbol,B_symbol,TargetGene,DrugID,DrugName,DrugTargets,C1_beta,C1_global_BY_q,NAnnotatedTargets,MultitargetFlag,Dataset,target_equals_A,target_equals_B,response_scale,fit_status,design_tier,available_n00,available_n01,available_n10,available_n11,n00,n01,n10,n11,n_lineages,lineages_with_all_four_arms,n_total,beta_A_main_effect,beta_B_main_effect,beta_AxB_interaction,hc3_se_AxB,p_AxB,ci_low_AxB,ci_high_AxB,beta_11_vs_10_adjusted,p_11_vs_10_adjusted,beta_11_vs_01_adjusted,p_11_vs_01_adjusted,mean00,mean01,mean10,mean11,fit_df_resid,adjusted_for,burden_covariate_dropped,interpretation,q_global_BH,q_global_BY,interaction_significance,negative_interaction_direction +ENTREZ:7157,ENTREZ:3845,TP53,KRAS,KRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.0865308434948422,1.053430644354516e-22,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,23,256,71,7,12,64,33,2,2,116.0,0.06893716805936113,0.039276513976834175,-0.069965297167565,0.08601106932121647,0.4177200762420018,-0.24041904822348792,0.10048845388835792,-0.030688783190730824,0.45816635124965466,-0.0010281291082038652,0.9893673248350887,0.8285767371424902,0.87052085127121,0.8948333039029553,0.869348625186753,110.0,log_other_mut_burden|lin_Lung,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7194067979723364,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-A56085258-001-01-8,LGX818,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,309,32,72,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-06-0,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,322,31,72,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K05804044-001-18-5,AZ-628,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,301,31,67,20,4,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-06-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,299,27,67,20,6,11,4,17,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K09951645-001-11-8,dabrafenib,"BRAF, LIMK1, NEK11, RAF1, SIK1",-1.0910946187228885,8.417418398503914e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,315,28,63,21,6,10,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16478699-001-09-2,PLX-4720,"BRAF, KDR",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,341,32,73,22,6,11,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-07-3,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,332,32,71,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K16730910-001-10-7,regorafenib,"ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK",-1.0910946187228885,8.417418398503914e-08,18,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,311,30,68,21,5,10,3,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K20722021-001-02-1,CEP-32496,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,311,30,74,22,6,11,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-001-07-5,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,321,30,67,22,5,9,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K23984367-075-15-2,sorafenib,"BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET",-1.0910946187228885,8.417418398503914e-08,11,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,318,28,66,17,5,11,4,14,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K31866293-001-01-6,TAK-632,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,319,30,75,22,6,11,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-10-6,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,255,23,51,14,4,8,4,12,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K56343971-001-14-8,vemurafenib,"BRAF, RAF1",-1.0910946187228885,8.417418398503914e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,311,28,70,22,6,10,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K67578145-001-09-7,GDC-0879,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,295,25,62,20,5,10,3,17,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K78809024-001-05-7,SB-590885,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,313,31,65,21,6,11,4,18,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:673,TERT,BRAF,BRAF,BRD-K93123848-001-04-1,RAF265,BRAF,-1.0910946187228885,8.417418398503914e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,335,31,73,22,5,10,4,19,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07310275-001-02-5,PF-04691502,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,104,25,275,43,23,21,144,33,6,6,221.0,0.016670145644140905,0.007638032320371799,-0.012645888731947021,0.01854277551519581,0.4959965709016809,-0.0491987178012885,0.023906940337394458,-0.0050078564115752225,0.6515179461023466,0.004024256912193883,0.7169109678500301,0.6498399579570325,0.6597572874825723,0.6685239537462494,0.6616115245658355,211.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07955840-001-02-3,PF-05212384,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,168,39,7,7,258.0,-0.011378188738619857,-0.016586528674600063,-0.010212930519727822,0.02813460848839269,0.7169135387465532,-0.06562727052974801,0.045201409490292374,-0.026799459194327885,0.03852627659777067,-0.02159111925834768,0.30717428725160045,0.6341881271515507,0.6164869131460896,0.6210614224072644,0.5920213209716089,247.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.888972788045726,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K07972848-001-02-0,GSK2126458,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,95,23,243,41,22,21,128,32,6,6,203.0,0.050958750989214555,0.008147016211356196,-0.07065785861222577,0.03712222233334151,0.05847857172388686,-0.1438751935961056,0.002559476371654046,-0.06251084240086957,0.0007802120269311257,-0.01969910762301122,0.4442024470112561,0.434295828278248,0.4437102541281665,0.4788515313538086,0.42727163308734795,193.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-15-4,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,97,19,221,34,20,16,120,26,6,6,182.0,0.05794109712833645,0.01218000752379167,-0.018919208687246388,0.042787824152653774,0.6589264559737391,-0.10337604821870212,0.06553763084420934,-0.006739201163454719,0.8369769510669496,0.03902188844109006,0.2768753819396641,0.6376495764044858,0.6571762619379815,0.7049655417963158,0.6834826428863319,172.0,log_other_mut_burden|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8511133389660797,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K12184916-001-19-6,NVP-BEZ235,"ATR, MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,106,24,259,37,21,19,140,31,6,6,211.0,0.03789133016854296,0.03250058661640403,-0.03437227791300379,0.07458022164238072,0.6453854261634264,-0.1814322816310161,0.11268772580500852,-0.0018716912965997604,0.9649965126160763,0.003519052255539168,0.9516610408119215,0.6698547843608885,0.7226031607838487,0.7311986974341583,0.6982159631309555,201.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.8511133389660797,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K23228615-001-02-8,GDC-0980,"FGR, MAP3K9, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SYK",-0.6206702665037973,8.899927369258888e-08,8,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,166,39,7,7,256.0,0.07275939149208684,0.04142531875772673,-0.13047440401568694,0.06714322242523242,0.05313431365793309,-0.26272600103231436,0.001777193000940508,-0.08904908525796021,0.011692621421973722,-0.057715012523600104,0.2396385983274672,0.6278646301413521,0.6743081185483546,0.7036738200893439,0.622818550234546,245.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K28352084-001-02-3,CH5132799,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,95,23,243,41,22,21,128,32,6,6,203.0,0.025204564635694753,0.020726937329580662,-0.0692570988523046,0.037167574123665545,0.06392876291024077,-0.14256388260879443,0.0040496849041852245,-0.04853016152272394,0.0017101281991096938,-0.04405253421660985,0.12734849098108697,0.7866327605838396,0.811344415044749,0.8089078748052413,0.7653141558715315,193.0,log_other_mut_burden|lin_Bowel|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K29415052-050-04-8,BGT226,"MTOR, PIK3CA, PIK3CB, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,23,269,43,26,20,153,37,7,7,236.0,0.04499480134339713,0.021535933386696987,-0.04710443977601195,0.02481223915432374,0.058918420638332226,-0.09599852988467772,0.001789650332653818,-0.02556850638931496,0.11201105349637742,-0.002109638432614816,0.9133437137055525,0.36927788786878984,0.38985703075835476,0.41516849495656516,0.384135876081157,225.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K42191735-001-05-3,buparlisib,"PIK3CA, PIK3CG",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,23,269,43,26,20,153,37,7,7,236.0,0.0049831784405988955,-0.029335338250940216,0.025487795022529125,0.029578750083313007,0.3897740078722587,-0.03279900702222684,0.0837745970672851,-0.0038475432284110905,0.7730204059467968,0.03047097346312802,0.10378235910675765,0.8007906401076527,0.7755548181711192,0.8084611952887748,0.8035261433826909,225.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K43187018-001-03-3,GDC-0349,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,110,27,287,44,27,24,165,38,7,7,254.0,0.0032362228681579713,-0.029272666765109447,0.038175121712891676,0.03151833314387216,0.22699393007228247,-0.023908883900410564,0.10025912732619391,0.008902454947782228,0.7132602429832213,0.04141134458104965,0.14393601056558097,0.6881328919652387,0.6585279723619152,0.6883092117381057,0.6967937208051362,243.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.5864009860200631,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K44844162-001-01-6,taselisib,PIK3CA,-0.6206702665037973,8.899927369258888e-08,1,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,109,27,286,44,27,24,164,38,7,7,253.0,-0.0022591111696113795,-0.16302883863805184,-0.0010056087022817044,0.06929581179458444,0.9884336017539428,-0.13750554750739366,0.13549433010283027,-0.16403444734033354,6.752744054232745e-06,-0.003264719871893084,0.9419054345349489,0.9265482658834119,0.7656954466718041,0.9154827525923138,0.7604616338544229,242.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9949638637299998,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K49371609-003-03-8,PIK-75,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,26,283,44,27,23,161,38,7,7,249.0,0.0076734988098081346,-0.005685624081194723,0.0001293682566934966,0.020474401813396284,0.9949638637299998,-0.04020482514385186,0.040463561657238856,-0.005556255824501226,0.5996558130302048,0.007802867066501631,0.5703612969012686,0.5773909802392874,0.5702040174350762,0.5840884293185764,0.5791309765125094,238.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9949638637299998,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K52911425-001-09-8,GDC-0941,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,113,27,283,44,26,24,163,38,7,7,251.0,0.051547387741240784,0.003424592111501954,-0.05031249327080605,0.04651436242995849,0.28049147922745427,-0.14194102581863843,0.04131603927702634,-0.04688790115930409,0.0336652818417517,0.001234894470434733,0.9716373793952314,0.8063133107201321,0.8163268371699995,0.8503938756041423,0.8190280483021364,240.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.668864296619314,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K54997624-001-06-0,alpelisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,25,284,43,27,22,162,37,7,7,248.0,0.003586243261420763,-0.05152243617078806,-0.03114175868966075,0.03588043397614651,0.38630981509251794,-0.10182707512633342,0.03954355774701192,-0.08266419486044882,1.0530034856783706e-06,-0.027555515428239988,0.3086429009885947,0.9147104330383843,0.8705474540302155,0.9157543742486377,0.8394902565078605,237.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K56291712-001-01-0,voxtalisib,"MTOR, PIK3CA",-0.6206702665037973,8.899927369258888e-08,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,109,26,289,42,26,23,168,36,7,7,253.0,0.14784976197120092,0.002007765728123531,-0.10174426458291345,0.0695346503183757,0.1447056733311694,-0.23871467112680378,0.035226141960976884,-0.09973649885478993,0.023257239071715452,0.04610549738828747,0.3691862827993515,0.9022101850501415,0.9161590829790441,1.0458918832921642,0.9612939537157001,242.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4485875873266252,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K58772419-001-07-0,AZD6482,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,168,39,7,7,258.0,0.0007149792461472191,0.005073949433970782,-0.0009645908893846124,0.02632567571692802,0.9708010952787895,-0.05281603022159488,0.05088684844282565,0.00410935854458617,0.7856045259111841,-0.0002496116432373933,0.9914879218478698,0.7746544190022375,0.7804220394767638,0.7712391825913081,0.7829337234748218,247.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9949638637299998,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K59317601-001-05-5,MLN0128,"MTOR, PIK3CA, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,288,45,27,24,166,39,7,7,256.0,-0.002952743316925712,0.0018653635187036999,-0.015289287154364714,0.04899161050126951,0.7552453848727977,-0.1117877645163118,0.08120919020758237,-0.013423923635661014,0.5472918491892791,-0.018242030471290426,0.5747647433496255,0.6021408446325394,0.6023240085133699,0.6060695379678454,0.5795109219201394,245.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9004848819637202,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K60866521-001-07-1,idelalisib,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,109,25,280,44,25,22,164,38,7,7,249.0,0.052747380589037086,0.05465827471888046,-0.055385489300728216,0.0353336314403238,0.11832629259692337,-0.1249920906093506,0.014221112007894166,-0.0007272145818477543,0.972294607481135,-0.0026381087116911298,0.9284026020807452,0.9718664962245056,1.0312517225301563,1.0246464394629862,1.0348704504832542,238.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4485875873266252,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K64785675-001-04-0,TG100-115,"PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,100,26,259,39,23,23,157,35,7,7,238.0,-0.08210343926983481,-0.0603171437322107,0.1008596169913151,0.06781400745859395,0.13832391326481366,-0.03276581723648128,0.23448505121911148,0.0405424732591044,0.2770262364845008,0.01875617772148029,0.6956301129134019,1.231197954630989,1.1704600589678562,1.15442761138992,1.1819407959863095,227.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4485875873266252,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K67868012-001-07-6,PI-103,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC",-0.6206702665037973,8.899927369258888e-08,6,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,107,25,282,43,26,23,162,37,7,7,248.0,0.04028541573807884,0.02746009391102816,-0.047861318854231755,0.02306285127587469,0.039041893113263795,-0.09329568961604837,-0.0024269480924151363,-0.020401224943203594,0.09914301868445242,-0.0075759031161529156,0.7133372974760972,0.8733025632058489,0.9000092378865243,0.9127047874027736,0.8951134615346998,237.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.3963583300434928,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K81801188-001-02-8,PP-121,"ABL1, EGFR, HCK, KDR, MTOR, PDGFRA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC, SRC",-0.6206702665037973,8.899927369258888e-08,12,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,111,26,287,44,26,23,164,38,7,7,251.0,0.006421749942353287,0.010653468563542448,-0.014786436736696149,0.023308744991097523,0.5264416837971981,-0.06070227837124332,0.031129404897851022,-0.0041329681731537005,0.7361028917576236,-0.008364686794342862,0.6067401148754841,0.5937593917214798,0.5988155920529126,0.5980820217865975,0.5985945604827884,240.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:5290,TP53,PIK3CA,PIK3CA,BRD-K98795921-001-01-7,SB-2343,"MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG",-0.6206702665037973,8.899927369258888e-08,5,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,115,27,289,45,27,24,168,39,7,7,258.0,0.024202717723320298,0.003980972622271865,-0.03379790741988856,0.019174988501371382,0.07920406834216334,-0.07156524770264383,0.003969432862866697,-0.029816934797616698,0.006609583447452828,-0.009595189696568265,0.4908722558752342,0.685927966515258,0.6903214665117012,0.7079402663374535,0.6857544083048009,247.0,log_other_mut_burden|lin_Bowel|lin_Breast|lin_Esophagus/Stomach|lin_Lung|lin_Ovary/Fallopian Tube|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4092210197678439,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:4893,TP53,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.3350632067960593,6.664587881992054e-07,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,126,9,314,13,24,2,10,4,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A55424491-001-19-9,methotrexate,DHFR,-0.5396753485849619,4.0947689964442364e-05,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,97,2,235,4,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-A74914197-001-02-9,pralatrexate,"DHFR, TYMS",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,139,2,332,6,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:2045,TP53,EPHA7,DHFR,BRD-K88429204-001-35-1,pyrimethamine,"DHFR, SLC47A1",-0.5396753485849619,4.0947689964442364e-05,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,137,2,320,6,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K18779551-003-07-8,bifemelane,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,131,2,304,2,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K59522102-001-14-6,piperine,"MAOA, MAOB, TRPV1",-0.0731544464992825,0.004497865529228015,3,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,132,2,304,3,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K87024524-065-17-7,phenelzine,"ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4",-0.0731544464992825,0.004497865529228015,10,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,117,2,271,2,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:55607,TP53,PPP1R9A,MAOB,BRD-K88568253-011-19-9,iproniazid,"MAOA, MAOB",-0.0731544464992825,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,111,2,269,2,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,CDKN1A,BRD-K19669037-001-01-1,GGTI-298,CDKN1A,-0.3248516515795884,0.04898412473432724,1,False,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,96,262,34,55,16,20,27,29,3,3,92.0,-0.01909203969482917,0.043547544626747675,-0.11930361389440697,0.0879133884557818,0.1783553756489049,-0.29409898279861635,0.05549175500980244,-0.07575606926765929,0.2143151008807582,-0.13839565358923614,0.021418469484927295,1.0935040192557122,1.141211711155972,1.0844214004459474,1.0260946168725,85.0,log_other_mut_burden|lin_CNS/Brain|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.502637876828732,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,98,251,38,53,20,23,29,34,4,4,106.0,-0.033049492547606626,0.20814575634740817,0.07893961968505336,0.08966114259266987,0.38078488447525516,-0.09898999971681086,0.2568692390869176,0.28708537603246154,1.639304655503293e-05,0.04589012713744674,0.44608473874378696,1.0514731251058782,1.274167930484132,0.9901431854794854,1.3197361547703812,98.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.6690480767468656,0.0017146919743462076,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,87,235,35,55,18,22,26,34,4,4,100.0,-0.04759920122733137,-0.13385727594329444,0.08277686288834052,0.09492232721143314,0.3854521454632128,-0.10574707235944475,0.2713007981361258,-0.05108041305495392,0.4593931912301701,0.03517766166100915,0.5707903600882867,1.1297725400104375,0.9800192406205359,1.1006767474177737,1.0455070972464928,92.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7107643672964717,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7015,ENTREZ:7157,TERT,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.6690480767468656,0.0017146919743462076,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,103,279,38,59,20,27,29,38,4,4,114.0,-0.06270831068146217,0.2318840807628262,0.10819948157923687,0.06386852138723229,0.09318321221060982,-0.018426074032575013,0.23482503719104875,0.34008356234206305,1.3804610181237192e-16,0.0454911708977747,0.2248842216718609,0.7076865638071071,0.941867144007823,0.6415571202652844,0.9864986275611597,106.0,log_other_mut_burden|lin_CNS/Brain|lin_Liver|lin_Skin,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.4126685112184149,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7157,ENTREZ:127255,TP53,LRRIQ3,ASIC3,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.0915714228989641,0.0029856584920047316,19,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,120,2,282,8,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,108,283,28,21,3,7,23,6,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.8569077390316492,0.004497865529228015,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,99,268,23,22,3,6,21,6,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:673,ENTREZ:7157,BRAF,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.8569077390316492,0.004497865529228015,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,113,311,28,27,7,22,25,9,2,2,63.0,-0.033227052296769116,0.3173426658241724,0.015563881525019418,0.09860907272398277,0.8751452873362575,-0.18189738057747104,0.21302514362750988,0.33290654734919184,9.837506095969906e-10,-0.017663170771749698,0.7315044598221876,0.6483589519628248,0.9618057680417923,0.6357420175607738,0.9637961034254001,57.0,log_other_mut_burden|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9689108538365708,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-A12230535-001-06-7,nutlin-3,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,112,241,24,63,23,14,9,13,2,2,59.0,0.04492568058829746,0.42672075618429134,-0.07452004592073153,0.11084233594928133,0.5043089861834928,-0.2968416173626804,0.14780152552121734,0.3522007102635598,0.00043693313441426387,-0.029594365332434064,0.7254201394263124,0.9188246775933123,1.3604016038145137,0.9298162518012715,1.2750866472934017,53.0,log_other_mut_burden|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K11433652-001-17-0,aspirin,"AKR1C1, ASIC3, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PTGS1, PTGS2, RPS6KA3, TP53",-0.5935115896585544,0.011416622719899565,19,True,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,100,227,22,63,22,40,11,18,3,3,91.0,-0.14293387698261684,-0.08753737500420368,0.06348284586548616,0.0877012314907643,0.47116677750168423,-0.11092067088272217,0.2378863626136945,-0.024054529138717515,0.6956592133184683,-0.07945103111713067,0.12229362828781055,1.1429589939214162,1.0382021670159278,1.002282057948361,0.9890185149265882,84.0,log_other_mut_burden|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.7418041908051428,1.0,NOT_FDR_SIGNIFICANT,False +ENTREZ:7273,ENTREZ:7157,TTN,TP53,TP53,BRD-K62627508-001-01-5,idasanutlin,"MDM2, TP53",-0.5935115896585544,0.011416622719899565,2,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,TESTED,strict,117,267,24,71,25,45,12,22,3,3,104.0,-0.01786374508021854,0.33421755100883577,-0.014052639796129363,0.05498800054538934,0.7988330480941352,-0.12318859943183547,0.09508331983957674,0.3201649112127064,3.545987753191552e-13,-0.0319163848763479,0.45215641171465737,0.6446065274827206,0.947017059489352,0.6076103385150696,0.9237291446996422,97.0,log_other_mut_burden|lin_Skin|lin_Uterus,False,Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only,0.9171786848488219,1.0,NOT_FDR_SIGNIFICANT,True +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-A28970875-300-04-9,puromycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,135,2,314,10,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7157,ENTREZ:387,TP53,RHOA,RPL13A,BRD-K91370081-001-25-1,anisomycin,"NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1",-0.3952742324314789,0.015161818285072143,13,True,PRISM_19Q4_secondary_AUC,False,False,DRUG_AUC_LOWER_MORE_SENSITIVE,NO_FULLY_CROSSED_LINEAGE,strict,135,2,320,11,0,0,0,0,0,0,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False +ENTREZ:7015,ENTREZ:4893,TERT,NRAS,NRAS,BRD-K41599323-001-02-3,lonafarnib,"FNTA, HRAS, KRAS, NRAS",-1.43378483684841,0.02245943944149391,4,False,PRISM_19Q4_secondary_AUC,False,True,DRUG_AUC_LOWER_MORE_SENSITIVE,SPARSE_FOUR_GROUP_ARMS,strict,348,18,92,4,13,4,21,2,1,1,,,,,,,,,,,,,,,,,,,,,,,NOT_ESTIMABLE,False diff --git a/src/final_comutation/__init__.py b/src/final_comutation/__init__.py new file mode 100644 index 0000000000000000000000000000000000000000..b258beb84c37cd586281765473741e84718f930c --- /dev/null +++ b/src/final_comutation/__init__.py @@ -0,0 +1 @@ +# Standalone de novo cancer co-mutation atlas, no historical result inputs. diff --git a/src/final_comutation/core.py b/src/final_comutation/core.py new file mode 100644 index 0000000000000000000000000000000000000000..b033084496945341e74e2eb377ed782056a58971 --- /dev/null +++ b/src/final_comutation/core.py @@ -0,0 +1,1226 @@ +"""Numerical core adapted from the original submitted fresh DepMap 24Q4 notebook. +Calculates everything from official raw files. No historical HF results or checkpoint restore. +Primary discovery protocol definitions and HC3 estimator intentionally preserved. +""" +from __future__ import annotations +import os,sys,re,dataclasses,datetime,csv,gzip,hashlib,json,itertools,math,shutil,time,warnings,zipfile,io +from pathlib import Path +from collections import Counter,defaultdict +import numpy as np +import pandas as pd +from scipy import sparse,stats +from scipy.sparse import csc_matrix +from statsmodels.stats.multitest import multipletests +import requests + +@dataclasses.dataclass(frozen=True) +class Config: + root: str = os.environ.get('ATLAS_ROOT', '/kaggle/working/four_group_mutation_atlas') + figshare_article_id: int = 27993248 + figshare_version: int = 1 + pinned_release: str = 'DepMap 24Q4 Public v1 (machine-accessible verified release)' + seed: int = 20261026 + holdout_fraction: float = 0.20 + alpha: float = 0.05 + target_ci_halfwidth: float = 0.25 # precision criterion, NOT an effect/significance cutoff + expected_crispr_sigma: float = 0.45 # overwritten by robust empirical gene-effect SD, with provenance + min_per_arm_estimable: int = 5 # absolute model-identifiability guard, not primary power threshold + min_per_arm_for_four_group: int = 5 + min_residual_df: int = 8 + min_gene_observations: int = 12 + min_overlap_per_lineage_arm: int = 2 + max_condition_number: float = 1e9 + n_gsea_permutations: int = 250 + gsea_min_size: int = 10 + gsea_max_size: int = 300 + min_enrichment_genes: int = 5 + save_pair_chunk_rows: int = 500000 + batch_A_genes: int = 24 + run_four_group_interactions: bool = True + run_within_lineage: bool = True + run_pan_cancer: bool = True + download_optional_omics: bool = True + allow_unverified_wt_in_exploratory_analysis: bool = True + genotypes_require_both_matrices: bool = True + use_mutation_burden_covariate: bool = True + min_reporting_effect_gene: int = 1 # display limit only, no gene filtering + report_top_n: int = 20 + pathway_for_discoveries_only: bool = True + run_live: bool = True + +CFG = Config() +ROOT = Path(os.getenv("FINAL_COMUTATION_WORKSPACE", "/kaggle/working/final_comutation_run")) +RAW = ROOT / "raw" +OUT = ROOT / "results" / "Main_C1_C2" +SESSION = requests.Session() +SESSION.headers.update({"User-Agent": "FinalComutationFreshResearch/1.0 (academic reproducibility)"}) +KEYS = ["A", "B", "Scope", "Lineage", "gene"] +GENE_ID_RE = re.compile(r"^\s*(.*?)\s*\((\d+)\)\s*$") +PROTOCOL_HASH = "UNINITIALIZED" + +FIGSHARE_ARTICLE=f'https://api.figshare.com/v2/articles/{CFG.figshare_article_id}/versions/{CFG.figshare_version}' +FILE_ROLE = { + 'model': ['Model.csv'], + 'crispr': ['CRISPRGeneEffect.csv'], + 'damaging': ['OmicsSomaticMutationsMatrixDamaging.csv'], + 'hotspot': ['OmicsSomaticMutationsMatrixHotspot.csv'], + 'expression': ['OmicsExpressionProteinCodingGenesTPMLogp1.csv', 'OmicsExpressionTPMLogp1HumanProteinCodingGenes.csv'], + 'copy_number': ['OmicsCNGene.csv','OmicsCNGeneWGS.csv'], + 'common_essential': ['CRISPRInferredCommonEssentials.csv','AchillesCommonEssentialControls.csv'], +} +REQUIRED_ROLES=('model','crispr','damaging','hotspot') +SOURCE_LOCK=[{'role': 'model', 'name': 'Model.csv', 'id': 51065297, 'size': 645696, 'computed_md5': '675210d17675f3517b0ce39a3c274f16', 'download_url': 'https://ndownloader.figshare.com/files/51065297'}, {'role': 'crispr', 'name': 'CRISPRGeneEffect.csv', 'id': 51064667, 'size': 428678699, 'computed_md5': '6edf7ade09b9b34199210b559d4745d3', 'download_url': 'https://ndownloader.figshare.com/files/51064667'}, {'role': 'damaging', 'name': 'OmicsSomaticMutationsMatrixDamaging.csv', 'id': 51065747, 'size': 147655356, 'computed_md5': 'cb20fdbe1cf3b9b0d8ed4f53e1f399b6', 'download_url': 'https://ndownloader.figshare.com/files/51065747'}, {'role': 'hotspot', 'name': 'OmicsSomaticMutationsMatrixHotspot.csv', 'id': 51065750, 'size': 4210723, 'computed_md5': 'a5aeb1deef897ead3c955c372148d840', 'download_url': 'https://ndownloader.figshare.com/files/51065750'}, {'role': 'expression', 'name': 'OmicsExpressionProteinCodingGenesTPMLogp1.csv', 'id': 51065489, 'size': 506628654, 'computed_md5': '71794802b750ce77c422dad0720a40af', 'download_url': 'https://ndownloader.figshare.com/files/51065489'}, {'role': 'copy_number', 'name': 'OmicsCNGene.csv', 'id': 51065324, 'size': 1394554236, 'computed_md5': '4696565fa74dc805983bc278b4a41802', 'download_url': 'https://ndownloader.figshare.com/files/51065324'}, {'role': 'common_essential', 'name': 'CRISPRInferredCommonEssentials.csv', 'id': 51064916, 'size': 20795, 'computed_md5': '545edef0d377f252db6e5e675201bd77', 'download_url': 'https://ndownloader.figshare.com/files/51064916'}] +REACTOME_ZIP_URL='https://download.reactome.org/98/ReactomePathways.gmt.zip' +REACTOME_VERSION=98 +REACTOME_SHA256='6056fcd95dc8f09740c8bb64c2765bea1386ce91b9b19cd10bcd45d30451805c' + +def initialize(workspace: str|Path): + global ROOT,RAW,OUT,CFG,PROTOCOL_HASH + root=Path(workspace).resolve() + if root in [Path('/'),Path('/kaggle/working'),Path('/mnt/data')]: + raise ValueError('Unsafe output root') + if root.exists() and any(root.iterdir()): + raise RuntimeError('Fresh-run isolation: output directory already contains files. Choose a NEW run directory; never reuse earlier results.') + ROOT=root; RAW=root/'raw'; OUT=root/'results'/'Main_C1_C2' + CFG=dataclasses.replace(Config(),root=str(root)) + for d in [RAW,OUT,*(OUT/k for k in ('tests','pathways','gene_tests','gene_tests_raw','validation','reports','qc'))]: d.mkdir(parents=True,exist_ok=True) + frozen=dataclasses.asdict(CFG) + frozen.update({'researcher_review':'PENDING','conditional_estimand':'E[CRISPR X | A=1,B=1] - E[CRISPR X | A=1,B=0]', + 'drug_estimand':'E[PRISM AUC | A=1,B=1] - E[PRISM AUC | A=1,B=0]', + 'interaction_auxiliary':'A*B non-additive association, not necessary for conditional estimand', + 'mutation_call':'OR(damaging,hotspot); zero is no reported qualifying mutation, NOT verified WT', + 'source_policy':'Only raw provider releases fetched in this run; never read previous result repositories', + 'multiplicity':'Original Simes pair BH / within BH / global gene-context BH, BY dependence sensitivity'}) + save_json(frozen,OUT/'protocol.json') + PROTOCOL_HASH=sha256_file(OUT/'protocol.json') + return root + + + +def sha256_file(path, block=2**20): + h=hashlib.sha256() + with open(path,'rb') as f: + for chunk in iter(lambda:f.read(block),b''):h.update(chunk) + return h.hexdigest() + + +def save_json(obj, path): + path=Path(path); path.parent.mkdir(parents=True,exist_ok=True) + temp=path.with_name(path.name+'.tmp') + with open(temp,'w') as f: json.dump(obj,f,indent=2,sort_keys=True,default=str) + os.replace(temp,path) + return path + + +def request_json(url, attempts=3): + last=None + for trial in range(attempts): + try: + r=SESSION.get(url,timeout=60) + r.raise_for_status() + if 'json' not in r.headers.get('content-type','').lower(): + raise ValueError(f'Non-JSON provider response for {url}; possible verification page') + return r.json() + except Exception as e: + last=e + if trial+10 + if verified(dest):return dest + if dest.exists():dest.unlink() + url=file_obj.get('download_url') or f'https://ndownloader.figshare.com/files/{file_obj["id"]}' + last=None + for attempt in range(4): + part=dest.with_suffix(dest.suffix+'.part') + try: + with SESSION.get(url,stream=True,timeout=(45,240)) as r: + r.raise_for_status() + content=r.headers.get('content-type','').lower() + if 'text/html' in content:raise RuntimeError(f'Download returned HTML, not {dest.name}') + with open(part,'wb') as dst: + for ch in r.iter_content(2**20): + if ch:dst.write(ch) + part.replace(dest) + if not verified(dest): + dest.unlink(missing_ok=True) + raise RuntimeError(f'Provider checksum/size mismatch: {file_obj["name"]}') + return dest + except Exception as e: + last=e;part.unlink(missing_ok=True) + if attempt<3:time.sleep(3*(attempt+1)) + raise RuntimeError(f'Failed verified download of {dest.name}: {last}') + + +def fetch_inputs(): + inv=figshare_inventory() + rows=[]; downloaded={} + for role,aliases in FILE_ROLE.items(): + obj=choose_file(inv,aliases,required=role in REQUIRED_ROLES) + if obj is None: + rows.append(dict(role=role,status='not_available_in_release',filename=None)) + if role in REQUIRED_ROLES:raise RuntimeError(f'Missing mandatory role {role}') + continue + try: + print('Downloading/verifying',role,obj['name'],int(obj.get('size',0)),'bytes',flush=True) + path=download_file(obj,RAW/obj['name']) + downloaded[role]=path + rows.append(dict(role=role,status='verified',filename=obj['name'],bytes=path.stat().st_size, + sha256=sha256_file(path),provider_id=obj['id'],provider_md5=obj.get('computed_md5'),url=obj.get('download_url'))) + except Exception as e: + rows.append(dict(role=role,status='download_error',filename=obj['name'],error=str(e))) + if role in REQUIRED_ROLES: + pd.DataFrame(rows).to_csv(OUT/'dataset_manifest.csv',index=False) + raise + pd.DataFrame(rows).to_csv(OUT/'dataset_manifest.csv',index=False) + save_json({role:str(path) for role,path in downloaded.items()},OUT/'downloaded_file_paths.json') + return downloaded + + +def gene_key(label): + s=str(label).strip() + m=GENE_ID_RE.match(s) + if m:return 'ENTREZ:'+m.group(2) + if s.isdecimal():return 'ENTREZ:'+s + return 'SYMBOL:'+s.upper() + + +def gene_symbol(label): + m=GENE_ID_RE.match(str(label)) + return m.group(1).strip() if m else str(label).strip() + + +def read_model(path): + df=pd.read_csv(path,low_memory=False) + idcol=next((x for x in ['ModelID','DepMap_ID','DepMapID','Unnamed: 0'] if x in df.columns),None) + lineage_col=next((x for x in ['OncotreeLineage','lineage','Lineage','primary_disease','OncotreePrimaryDisease'] if x in df.columns),None) + if not idcol or not lineage_col:raise ValueError(f'Model.csv missing model id or lineage; columns={list(df.columns)}') + df=df.rename(columns={idcol:'ModelID',lineage_col:'Lineage'}) + df['ModelID']=df.ModelID.astype(str).str.strip() + if df.ModelID.duplicated().any():raise ValueError('ModelID duplicated in model metadata') + df['Lineage']=df.Lineage.fillna('Unclassified').astype(str) + if (df.ModelID.str.match(r'^ACH-\d{6}$').mean()<0.8):raise ValueError('Unexpected ModelID mapping') + return df.set_index('ModelID',drop=True) + + +def read_gene_matrix(path, kind, accepted=None): + header=pd.read_csv(path,nrows=0).columns.tolist() + if len(header)<2:raise ValueError(f'{kind}: too few matrix fields') + idcol=header[0] + cols=[]; renames={}; label_map={} + for h in header[1:]: + k=gene_key(h) + if accepted is not None and k not in accepted:continue + if k in label_map:raise ValueError(f'Duplicate canonical gene id {k} in {kind}') + cols.append(h);renames[h]=k;label_map[k]=gene_symbol(h) + if not cols:raise ValueError(f'No analyzable genes in {kind}') + dat=pd.read_csv(path,usecols=[idcol]+cols,low_memory=False) + dat=dat.rename(columns={idcol:'ModelID',**renames}) + dat.ModelID=dat.ModelID.astype(str).str.strip() + if dat.ModelID.duplicated().any():raise ValueError(f'{kind}: duplicate model ids') + dat=dat.set_index('ModelID') + for col in dat.columns: + if dat[col].dtype.kind not in 'iuf': + dat[col]=pd.to_numeric(dat[col],errors='coerce') + dat=dat.astype(np.float32) + if kind=='crispr' and (np.isfinite(dat.values).sum()==0):raise ValueError('Empty CRISPR assay') + if kind in ['damaging','hotspot']: + observed=dat.to_numpy() + vals=observed[np.isfinite(observed)] + if np.any(vals<0) or np.any((vals!=np.floor(vals))):raise ValueError(f'{kind}: invalid categorical dosage values') + return dat,label_map + + +def integrate_data(paths): + models=read_model(paths['model']) + crispr,cri_names=read_gene_matrix(paths['crispr'],'crispr') + damaging,dam_names=read_gene_matrix(paths['damaging'],'damaging') + hotspot,hot_names=read_gene_matrix(paths['hotspot'],'hotspot') + ids=models.index.intersection(crispr.index).intersection(damaging.index).intersection(hotspot.index) + if len(ids)<30:raise RuntimeError('Too few same-model genotype+CRISPR profiles to support research') + # Strict: both mutation matrices must have a gene field; no absent field -> assumed WT. + common_genes=sorted(set(damaging.columns)|set(hotspot.columns)) + if not common_genes:raise RuntimeError('Damaging/hotspot mutation matrices have no gene columns') + damaging_original=set(damaging.columns); hotspot_original=set(hotspot.columns) + damaging=damaging.reindex(index=ids,columns=common_genes) + hotspot=hotspot.reindex(index=ids,columns=common_genes) + da=damaging.to_numpy(dtype=np.float32,copy=False) + ho=hotspot.to_numpy(dtype=np.float32,copy=False) + both_observed=np.isfinite(da)&np.isfinite(ho) + G=np.where(((da>0)&np.isfinite(da))|((ho>0)&np.isfinite(ho)),1, + np.where(both_observed,0,np.nan)).astype('float32') + G=pd.DataFrame(G,index=ids,columns=common_genes) + positives=(G==1).sum(axis=0) + candidates=sorted(positives[positives>0].index) + G=G[candidates] + crispr=crispr.loc[ids] + models=models.loc[ids] + names={**cri_names,**dam_names,**hot_names} + # Positives are annotated damaging/hotspot, not proof of oncogenic functionality. + registry=pd.DataFrame({'gene':candidates,'gene_symbol':[names.get(g,g) for g in candidates], + 'n_reported_mutated':[int(positives[g]) for g in candidates], + 'damaging_matrix_has_gene':[g in damaging_original for g in candidates], + 'hotspot_matrix_has_gene':[g in hotspot_original for g in candidates], + 'n_genotype_unknown':[int(G[g].isna().sum()) for g in candidates]}) + registry.to_csv(OUT/'gene_candidate_registry.csv',index=False) + qc={'n_models':len(ids),'n_genotype_genes_all':len(common_genes),'n_genotype_genes_with_any_positive':len(candidates), + 'n_crispr_genes':crispr.shape[1],'total_genotype_unknown':int(G.isna().sum().sum()), + 'gt_zero_means':'No reported damaging/hotspot; B-WT not verified without per-gene callability evidence', + 'lineages':models.Lineage.value_counts().to_dict()} + save_json(qc,OUT/'qc'/'integration_qc.json') + return models,crispr,G,names + + +def partition_models(models,seed=CFG.seed,frac=CFG.holdout_fraction): + """Stable global model split, stratified on lineage; no outcome-based splitting.""" + discovery=set();holdout=set() + # Related patient-derived models cannot be guaranteed independent; flag, group if common patient ID. + patient_col=next((s for s in ['PatientID','patient_id','Patient','patient'] if s in models.columns),None) + for lineage,group in models.groupby('Lineage',sort=True): + if patient_col is not None: + vals=group[patient_col].fillna(group.index.to_series()).astype(str) + else: + vals=pd.Series(group.index,index=group.index) + clus=defaultdict(list) + for m,v in vals.items():clus[v].append(m) + clusters=list(clus.items()) + clusters.sort(key=lambda x:hashlib.sha256(f'{seed}|{lineage}|{x[0]}'.encode()).hexdigest()) + target=round(len(group)*frac) + k=0 + for _,members in clusters: + if k=2: + holdout.update(members); k+=len(members) + else: discovery.update(members) + if patient_col is not None: + dp=set(models.loc[sorted(discovery),patient_col].dropna().astype(str))-{'','nan','Unknown','unknown'} + hp=set(models.loc[sorted(holdout),patient_col].dropna().astype(str))-{'','nan','Unknown','unknown'} + if dp & hp:raise RuntimeError('Known patient overlap across partitions; researcher must review grouping before computation') + assert not (discovery&holdout) + assert discovery|holdout==set(models.index) + pd.DataFrame({'ModelID':models.index,'partition':['holdout' if i in holdout else 'discovery' for i in models.index], + 'Lineage':models.Lineage.to_numpy()}).to_csv(OUT/'model_partition.csv',index=False) + return sorted(discovery),sorted(holdout) + + +def empirical_sigma(Y): + # Median SD across genes measured for >=30 models; avoids arbitrary power filtering based on results. + z=Y.to_numpy(dtype=float) + sd=np.nanstd(z,axis=0,ddof=1) + ns=np.sum(np.isfinite(z),axis=0) + s=np.median(sd[(ns>=30)&(sd>0)&np.isfinite(sd)]) if np.any((ns>=30)&(sd>0)&np.isfinite(sd)) else CFG.expected_crispr_sigma + return float(s) + + +def status_from_counts(n10,n11,sigma,halfwidth=CFG.target_ci_halfwidth): + """Status is determined BEFORE dependency p-values are examined.""" + n10=np.asarray(n10);n11=np.asarray(n11) + z=stats.norm.ppf(1-CFG.alpha/2) + half=z*sigma*np.sqrt(1/np.maximum(n10,1)+1/np.maximum(n11,1)) + minimum=CFG.min_per_arm_estimable + status=np.where((n100 + out=Path(out or OUT/'all_ordered_pair_feasibility.csv.gz') + out.parent.mkdir(parents=True,exist_ok=True) + batch=int(batch or CFG.batch_A_genes) + enumerated=0;statuses=Counter(); eligible=[] + # Fail if preexisting report is incomplete instead of merging duplicated rows. + with gzip.open(out,'wt',newline='') as f: + writer=csv.writer(f) + writer.writerow(['a_index','b_index','n00','n01','n10','n11','n_genotyped','est_ci_halfwidth','feasibility_code']) + all_b=np.arange(K,dtype=np.int32) + for start in range(0,K,batch): + aa=np.arange(start,min(K,start+batch),dtype=np.int32) + mm=(M[:,aa].T@M).toarray().astype(np.int32) + if has_na: + mu=(M[:,aa].T@U).toarray().astype(np.int32) + um=(U[:,aa].T@M).toarray().astype(np.int32) + uu=(U[:,aa].T@U).toarray().astype(np.int32) + else: + mu=um=uu=np.zeros_like(mm) + n11=mm + n10=nm[aa,None]-mm-mu + n01=nm[None,:]-mm-um + valid=N-nu[aa,None]-nu[None,:]+uu + n00=valid-n11-n10-n01 + if min(n00.min(),n01.min(),n10.min(),n11.min())<0: + raise AssertionError('Negative four-group genotype count') + half,status=status_from_counts(n10,n11,sigma) + for row,a in enumerate(aa): + mask=all_b!=a + bb=all_b[mask] + writer.writerows((int(a),int(b),int(z00),int(z01),int(z10),int(z11),int(zv), + round(float(zh),6),int(zs)) + for b,z00,z01,z10,z11,zv,zh,zs in zip(bb,n00[row,mask],n01[row,mask], + n10[row,mask],n11[row,mask],valid[row,mask],half[row,mask],status[row,mask])) + enumerated+=len(bb) + counts=np.bincount(status[row,mask],minlength=3) + statuses.update({i:0 for i in range(3)}) + for k,c in enumerate(counts):statuses[k]+=int(c) + idx=np.flatnonzero(status[row,:]>=1) + idx=idx[idx!=a] + for b in idx: + eligible.append((int(a),int(b),int(n00[row,b]),int(n01[row,b]),int(n10[row,b]),int(n11[row,b]), + float(half[row,b]),int(status[row,b]))) + if enumerated!=K*(K-1):raise AssertionError('All-pair inventory incomplete') + status_name={0:'not_estimable',1:'exploratory',2:'precision_eligible'} + elig=pd.DataFrame(eligible,columns=['a_index','b_index','n00','n01','n10','n11','expected_ci_halfwidth','feasibility_code']) + elig['A']=elig.a_index.map(dict(enumerate(genes))); elig['B']=elig.b_index.map(dict(enumerate(genes))) + elig['feasibility_status']=elig.feasibility_code.map(status_name) + elig.to_csv(OUT/'estimable_pair_registry.csv.gz',index=False,compression='gzip') + summary={'n_candidate_genes':K,'n_ordered_pairs_enumerated':enumerated,'n_nonestimable':statuses[0], + 'n_exploratory':statuses[1],'n_precision_eligible':statuses[2], + 'full_inventory_path':str(out),'full_inventory_sha256':sha256_file(out), + 'all_four_groups_recorded':True,'no_pair_pretruncation':True, + 'status_definition':'n10/n11>=minimum design rank; normal 95pct expected interval halfwidth based on global empirical sigma', + 'sigma':sigma,'halfwidth_target':CFG.target_ci_halfwidth} + save_json(summary,OUT/'pair_feasibility_manifest.json') + return elig,summary + + +def bh_adjust(values, method='fdr_bh'): + p=np.asarray(values,dtype=float) + out=np.full(p.shape,np.nan,dtype=float) + ix=np.flatnonzero(np.isfinite(p)) + if len(ix):out[ix]=multipletests(p[ix],method=method)[1] + return out + + +def simes_pvalue(values): + p=np.sort(np.asarray(values,dtype=float)) + p=p[np.isfinite(p)] + if not len(p):return np.nan + return float(np.clip(np.min(p*len(p)/np.arange(1,len(p)+1)),0,1)) + + +def hc3_one_matrix(X,Y,interest, min_df=CFG.min_residual_df): + """Return gene-specific coefficient, HC3 SE, t, p, confidence interval, n. + Gene-wise finite masks are respected. Gaussian OLS + t reference is a modeling + assumption; not guaranteed for tiny, nonexchangeable cell-line cohorts. + """ + X=np.asarray(X,dtype=np.float64) + Y=np.asarray(Y,dtype=np.float64) + if X.ndim!=2 or Y.ndim!=2 or X.shape[0]!=Y.shape[0]:raise ValueError('X/Y dimensions') + if not np.isfinite(X).all():raise ValueError('X has nonfinite values') + if not (0<=interestCFG.max_condition_number:continue + inv=np.linalg.inv(xx.T@xx) + H=inv@xx.T + b=H@yy + residual=yy-xx@b + h=np.sum(xx*H.T,axis=1) + if np.any(h>=0.999999):continue + w=(H[interest,:]/(1-h))**2 + v=w@(residual**2) + se=np.sqrt(np.maximum(v,0)) + valid=se>1e-12 + if not np.any(valid):continue + tstat=np.full(len(cols),np.nan) + tstat[valid]=b[interest,valid]/se[valid] + pv=np.full(len(cols),np.nan) + pv[valid]=2*stats.t.sf(np.abs(tstat[valid]),nk-p) + crit=stats.t.ppf(1-CFG.alpha/2,nk-p) + out[cols,0]=b[interest] + out[cols,1]=se + out[cols,2]=tstat + out[cols,3]=pv + out[cols,4]=b[interest]-crit*se + out[cols,5]=b[interest]+crit*se + out[cols,6]=nk + return pd.DataFrame(out,columns=['beta','se_hc3','t_hc3','p','ci_low','ci_high','n_gene']) + + +def standard_smd(group1,group2): + aa=np.asarray(group1,dtype=float);bb=np.asarray(group2,dtype=float) + if len(aa)<2 or len(bb)<2:return np.nan + sd=np.sqrt((np.nanvar(aa,ddof=1)+np.nanvar(bb,ddof=1))/2) + return float((np.nanmean(bb)-np.nanmean(aa))/sd) if sd>1e-12 else 0.0 + + +def get_mutation_burden(G): + return (G==1).sum(axis=1).astype(float) + + +def design_for_context(metadata,mode='conditional',include_lineage=True): + df=metadata.copy() + X=pd.DataFrame({'intercept':np.ones(len(df))},index=df.index) + if mode=='conditional': + X['B_mut']=df['B'].to_numpy(dtype=float) + interest='B_mut' + elif mode=='interaction': + X['A_mut']=df['A'].to_numpy(dtype=float) + X['B_mut']=df['B'].to_numpy(dtype=float) + X['A_x_B']=X['A_mut']*X['B_mut'] + interest='A_x_B' + else:raise ValueError(mode) + if CFG.use_mutation_burden_covariate: + cov=np.log1p(np.maximum(df['other_mut_burden'].to_numpy(dtype=float),0)) + if np.nanstd(cov)>1e-8: + X['log_other_mutation_burden']=cov + if include_lineage and df.Lineage.nunique()>1: + dum=pd.get_dummies(df.Lineage,prefix='lin',drop_first=True,dtype=float) + X=pd.concat([X,dum],axis=1) + xx=X.to_numpy(dtype=float) + if not np.isfinite(xx).all() or np.linalg.matrix_rank(xx)CFG.max_condition_number: + raise ValueError('Ill-conditioned context adjustment design') + if len(df)-xx.shape[1]=CFG.min_overlap_per_lineage_arm)& + (counts[1.0]>=CFG.min_overlap_per_lineage_arm)] + meta=meta.loc[meta.Lineage.isin(good)] + n0=int((meta.B==0).sum());n1=int((meta.B==1).sum()) + if min(n0,n1)=CFG.min_overlap_per_lineage_arm:keep.append(lin) + meta=meta.loc[meta.Lineage.isin(keep)] + cnt=four_group_counts(meta) + if min(cnt.values())=CFG.min_per_arm_estimable: + scenarios.append(('within_lineage',str(lin),'conditional')) + if CFG.run_four_group_interactions and str(A)=CFG.min_per_arm_for_four_group: + scenarios.append(('four_group_interaction',None,'interaction')) + for scope,lin,kind in scenarios: + fname=context_file(A,B,scope,lin,kind) + fit,diagnostic=model_fits_for_context(ctx,models,G,effects,burden,scope,kind,lin) + info={'A':A,'B':B,'A_symbol':names.get(A,A),'B_symbol':names.get(B,B), + 'Scope':scope,'Lineage':lin or 'PAN_CANCER','test_kind':kind, + 'result_file':str(fname),**diagnostic} + if fit is not None: + fitted_meta=context_metadata(models,G,G.columns,A,B,discovery_ids,burden,kind,lin) + if kind=='conditional' and lin is None: + overlap=pd.crosstab(fitted_meta.Lineage,fitted_meta.B) + for v in [0.0,1.0]: + if v not in overlap.columns:overlap[v]=0 + matched=overlap.index[(overlap[0.0]>=CFG.min_overlap_per_lineage_arm)&(overlap[1.0]>=CFG.min_overlap_per_lineage_arm)] + fitted_meta=fitted_meta[fitted_meta.Lineage.isin(matched)] + if kind=='interaction' and lin is None: + matched=[name for name,sub in fitted_meta.groupby('Lineage') if min(four_group_counts(sub).values())>=CFG.min_overlap_per_lineage_arm] + fitted_meta=fitted_meta[fitted_meta.Lineage.isin(matched)] + fc=four_group_counts(fitted_meta) + if kind=='conditional': + precision_half,status=status_from_counts(fc['n10'],fc['n11'],sigma) + else: + precision_half,status=np.nan,1 + info.update(n10_fit=fc['n10'],n11_fit=fc['n11'],n00_fit=fc['n00'],n01_fit=fc['n01'], + fit_expected_ci_halfwidth=float(precision_half), + inferential_tier='precision_eligible' if int(status)==2 and kind=='conditional' else 'exploratory') + if fit is None: + info.update(status='not_estimable_after_adjustment',n_tested_genes=0,p_simes=np.nan) + else: + fit['A']=A;fit['B']=B;fit['Scope']=scope;fit['Lineage']=lin or 'PAN_CANCER' + fit['test_kind']=kind + fit['q_within']=bh_adjust(fit.p) + info.update(status='gene_tests_completed',n_tested_genes=int(fit.p.notna().sum()), + p_simes=simes_pvalue(fit.p)) + fit.to_csv(fname,index=False,compression='gzip') + context_rows.append(info) + processed+=1 + if processed%100==0: + pd.DataFrame(context_rows).to_csv(OUT/'context_manifest_checkpoint.csv',index=False) + print('Pairs processed:',processed,'/',len(elig),'contexts:',len(context_rows)) + pair_df=pd.DataFrame(pair_rows) + ctxt_df=pd.DataFrame(context_rows) + pair_df.to_csv(OUT/'estimable_pair_four_group_counts.csv.gz',index=False,compression='gzip') + ctxt_df.to_csv(OUT/'context_manifest.csv',index=False) + return pair_df,ctxt_df + + +def global_multiplicity(contexts): + """Two pass, disk-backed multiplicity; never load all result tables at once. + + Pair-level Simes+BH screening and within-pair BH are reported. Global BH is + the principal gene-context correction under BH dependence assumptions; + global BY is supplied for arbitrary-dependence sensitivity. This is NOT a + claim of exact hierarchical FDR control under arbitrary nonexchangeability. + """ + df=contexts.copy() + df['q_pair_simes_BH']=np.nan + df['q_pair_simes_BY']=np.nan + for family in ['pan_cancer_conditional','within_lineage','four_group_interaction']: + mask=df.Scope.eq(family) + df.loc[mask,'q_pair_simes_BH']=bh_adjust(df.loc[mask,'p_simes']) + df.loc[mask,'q_pair_simes_BY']=bh_adjust(df.loc[mask,'p_simes'],'fdr_by') + selected_rows=[] + for family in ['pan_cancer_conditional','within_lineage','four_group_interaction']: + scopes=df[(df.Scope==family)&df.result_file.notna()&df.status.eq('gene_tests_completed')] + if scopes.empty:continue + # Identical full gene matrix is retained per scope; count from any one result. + first=pd.read_csv(scopes.iloc[0].result_file,compression='gzip',usecols=['p']) + ng=len(first);total=len(scopes)*ng + del first + pfilename=OUT/'qc'/f'global_p_{family}.bin' + ps=np.memmap(pfilename,dtype='float64',mode='w+',shape=(total,)) + offset=0 + for record in scopes.itertuples(): + arr=pd.read_csv(record.result_file,compression='gzip',usecols=['p']).p.to_numpy(float) + if len(arr)!=ng:raise ValueError('Genome-wide gene tests have inconsistent row counts') + ps[offset:offset+ng]=arr + offset+=ng + ps.flush() + # q matrices are computed once; release each before moving to next family. + q_bh=bh_adjust(ps,'fdr_bh') + q_by=bh_adjust(ps,'fdr_by') + offset=0 + for record in scopes.itertuples(): + tab=pd.read_csv(record.result_file,compression='gzip') + tab['q_global_BH']=q_bh[offset:offset+ng] + tab['q_global_BY']=q_by[offset:offset+ng] + offset+=ng + tab['q_pair_BH']=getattr(record,'q_pair_simes_BH') + tab['q_pair_BY']=getattr(record,'q_pair_simes_BY') + tab['discovery_signal']=((tab.beta<0)&(tab.q_global_BH<=CFG.alpha)& + (tab.q_pair_BH<=CFG.alpha)&(tab.q_within<=CFG.alpha)) + tab['primary_pan_cancer_signal']=(tab.discovery_signal & (family=='pan_cancer_conditional') & + (getattr(record,'inferential_tier','exploratory')=='precision_eligible')) + tab['inferential_tier']=getattr(record,'inferential_tier','exploratory') + tab['dependence_robust_signal']=(tab.discovery_signal & (tab.q_global_BY<=CFG.alpha)& + (tab.q_pair_BY<=CFG.alpha)) + target=OUT/'gene_tests'/Path(record.result_file).name + tab.to_csv(target,index=False,compression='gzip') + df.loc[record.Index,'result_file']=str(target) + if tab.discovery_signal.any(): + t=tab.loc[tab.discovery_signal].copy() + t['context_type']=family + selected_rows.append(t) + del ps,q_bh,q_by + pfilename.unlink(missing_ok=True) + df.to_csv(OUT/'context_manifest_with_multiplicity.csv',index=False) + if selected_rows:selected=pd.concat(selected_rows,ignore_index=True) + else:selected=pd.DataFrame(columns=['gene','A','B','Scope','Lineage','beta','se_hc3','p', + 'q_within','q_global_BH','q_global_BY','q_pair_BH','q_pair_BY','discovery_signal', + 'dependence_robust_signal','primary_pan_cancer_signal','inferential_tier']) + selected.to_csv(OUT/'all_discovery_signals.csv.gz',index=False,compression='gzip') + return df,selected + + +def fetch_reactome(): + dst=RAW/'ReactomePathways.gmt.zip' + if not dst.exists() or not zipfile.is_zipfile(dst): + with SESSION.get(REACTOME_ZIP_URL,timeout=(40,180),stream=True) as r: + r.raise_for_status() + if 'html' in r.headers.get('content-type','').lower(): + raise RuntimeError('Reactome URL supplied an HTML page') + with open(dst.with_suffix('.part'),'wb') as f: + for ch in r.iter_content(2**20): + if ch:f.write(ch) + dst.with_suffix('.part').replace(dst) + if not zipfile.is_zipfile(dst):raise RuntimeError('Reactome source is not a valid GMT ZIP') + if sha256_file(dst)!=REACTOME_SHA256:raise RuntimeError('Pinned Reactome 98 checksum mismatch') + with zipfile.ZipFile(dst) as z: + names=[name for name in z.namelist() if name.lower().endswith('.gmt')] + if not names:raise RuntimeError('No Reactome GMT file in official ZIP') + data=z.read(names[0]).decode('utf-8-sig','replace') + pathways={} + for line in data.splitlines(): + row=line.strip().split('\t') + if len(row)<5:continue + name=row[0] + genes={x.upper().strip() for x in row[2:] if x.strip()} + if genes:pathways[name]=genes + save_json({'source':REACTOME_ZIP_URL,'sha256':sha256_file(dst),'n_pathways':len(pathways), + 'fetched_at':datetime.datetime.now(datetime.timezone.utc).isoformat(), + 'version':REACTOME_VERSION,'note':'Pinned official archive; SHA-256 required'},OUT/'pathway_source_manifest.json') + if len(pathways)<100:raise RuntimeError('Suspiciously few official Reactome pathways') + return pathways + + +def ora_for_context(ranked,interesting,pathways): + universe=set(ranked.keys());hits=set(interesting)&universe;N=len(universe) + rows=[] + if len(hits)=abs(mn) else mn + + +def prerank_gsea(ranked,pathways,seed=0,nperm=None): + """Pre-ranked weighted GSEA with gene-set permutations; FDR per context. + The permutation null is gene-set membership, NOT phenotype permutation. + Significant results require independent experimental evidence for validation. + """ + nperm=int(nperm or CFG.n_gsea_permutations) + sr=pd.Series(ranked,dtype=float).dropna().sort_values(ascending=False) + genes=list(sr.index);sc=sr.to_numpy();N=len(genes) + gene_pos={k:i for i,k in enumerate(genes)} + rng=np.random.default_rng(seed) + rows=[] + for name,members in pathways.items(): + ix=[gene_pos[g] for g in members if g in gene_pos] + k=len(ix) + if kCFG.gsea_max_size or k>=N:continue + es=gsea_es(sc,ix) + if not np.isfinite(es):continue + null=np.array([gsea_es(sc,rng.choice(N,size=k,replace=False)) for _ in range(nperm)]) + if es>=0: + neg=null[null>=0] + norm=np.mean(neg) if len(neg) else np.nan + p=(1+int((null>=es).sum()))/(nperm+1) + else: + neg=-null[null<0] + norm=np.mean(neg) if len(neg) else np.nan + p=(1+int((null<=es).sum()))/(nperm+1) + nes=es/norm if np.isfinite(norm) and norm>0 else np.nan + rows.append({'Pathway':name,'ES':es,'NES':nes,'p_nominal':p,'pathway_n':k, + 'n_permutations':nperm,'method':'preranked_GSEA_gene_set_permutation'}) + if not rows:return pd.DataFrame() + df=pd.DataFrame(rows) + df['q_pathway_BH']=bh_adjust(df.p_nominal) + return df.sort_values('q_pathway_BH') + + +def contextual_pathway_analysis(selected,contexts,names,pathways): + """Follow-up pathways run for every context with a dependency discovery signal. + No pathway discovery is required for a null genetic context. + """ + if selected.empty:return pd.DataFrame(),pd.DataFrame() + all_gsea=[];all_ora=[] + keys=selected[['A','B','Scope','Lineage']].drop_duplicates() + mapped_names={k:str(v).upper() for k,v in names.items()} + for row in keys.itertuples(index=False): + A,B,scope,lineage=row.A,row.B,row.Scope,row.Lineage + m=contexts[(contexts.A==A)&(contexts.B==B)&(contexts.Scope==scope)&(contexts.Lineage==lineage)] + if len(m)!=1:continue + file=Path(m.iloc[0].result_file) + if not file.exists():continue + df=pd.read_csv(file,compression='gzip') + df['symbol']=df.gene.map(mapped_names) + # Duplicate symbols are not considered separate enrichment units. + df=df.dropna(subset=['symbol','t_hc3']).sort_values('p').drop_duplicates('symbol') + ranked=dict(zip(df.symbol,-df.t_hc3)) + hits=set(df.loc[df.discovery_signal.astype(bool)&df.beta.lt(0),'symbol']) + ora=ora_for_context(ranked,hits,pathways) + gsea=prerank_gsea(ranked,pathways,seed=CFG.seed+int(hashlib.md5(f'{A}/{B}/{scope}/{lineage}'.encode()).hexdigest()[:8],16)) + for table,target in [(ora,all_ora),(gsea,all_gsea)]: + if len(table): + table=table.copy() + for col,val in [('A',A),('B',B),('Scope',scope),('Lineage',lineage)]:table[col]=val + target.append(table) + ora_all=pd.concat(all_ora,ignore_index=True) if all_ora else pd.DataFrame() + gsea_all=pd.concat(all_gsea,ignore_index=True) if all_gsea else pd.DataFrame() + ora_all.to_csv(OUT/'pathways'/'ora_all_contexts.csv.gz',index=False,compression='gzip') + gsea_all.to_csv(OUT/'pathways'/'preranked_gsea_all_contexts.csv.gz',index=False,compression='gzip') + return ora_all,gsea_all + + +def read_selected_omics(path,genes): + """Read only selected genes to avoid loading unnecessary ~GB expression/CN matrices.""" + header=pd.read_csv(path,nrows=0).columns.tolist() + idcol=header[0] + matches=[c for c in header[1:] if gene_key(c) in genes] + if not matches:return pd.DataFrame() + df=pd.read_csv(path,usecols=[idcol]+matches,low_memory=False) + df=df.rename(columns={idcol:'ModelID',**{c:gene_key(c) for c in matches}}) + df=df.set_index('ModelID') + df=df.apply(pd.to_numeric,errors='coerce') + if df.index.duplicated().any():raise ValueError('Omics matrix has duplicate models') + return df + + +def omics_evidence(selected,models,G,files): + if selected.empty: + pd.DataFrame(columns=['A','B','Scope','Lineage','gene','status']).to_csv(OUT/'molecular_support.csv',index=False) + return pd.DataFrame() + genes=set(selected.gene) + omics={} + for kind,role in [('expression','expression'),('copy_number','copy_number')]: + if role in files: + try:omics[kind]=read_selected_omics(files[role],genes) + except Exception as e: + print('Optional',kind,'unavailable:',e);omics[kind]=pd.DataFrame() + else:omics[kind]=pd.DataFrame() + results=[] + for record in selected.itertuples(): + for kind,mat in omics.items(): + if mat.empty or record.gene not in mat.columns: + results.append({'A':record.A,'B':record.B,'gene':record.gene,'Scope':record.Scope, + 'Lineage':record.Lineage,'assay':kind,'status':'not_available'}) + continue + # This is a supplementary unadjusted contrast, not a validation of causal mechanism. + pair=G[[record.A,record.B]].dropna() + x=pair[(pair[record.A]==1)&(pair.index.isin(mat.index))] + if record.Lineage!='PAN_CANCER':x=x.loc[models.loc[x.index,'Lineage'].eq(record.Lineage)] + t=pd.to_numeric(mat.loc[x.index,record.gene],errors='coerce') + c=t.loc[x[record.B]==0].dropna().to_numpy(float) + y=t.loc[x[record.B]==1].dropna().to_numpy(float) + status='observed_unadjusted_only' if min(len(c),len(y))>=3 else 'underpowered' + delta=float(y.mean()-c.mean()) if len(c) and len(y) else np.nan + p=float(stats.ttest_ind(y,c,equal_var=False).pvalue) if min(len(c),len(y))>=3 else np.nan + results.append({'A':record.A,'B':record.B,'gene':record.gene,'Scope':record.Scope, + 'Lineage':record.Lineage,'assay':kind,'status':status,'n_control':len(c), + 'n_target':len(y),'delta_unadjusted':delta,'p_exploratory':p, + 'not_independent_validation':True}) + out=pd.DataFrame(results) if results else pd.DataFrame(columns=['A','B','Scope','Lineage','gene','status']) + if len(out): + if 'p_exploratory' not in out.columns:out['p_exploratory']=np.nan + out['q_exploratory_assay']=np.nan + for assay,idx in out.groupby('assay').groups.items():out.loc[idx,'q_exploratory_assay']=bh_adjust(out.loc[idx,'p_exploratory']) + out.to_csv(OUT/'molecular_support.csv',index=False) + return out + + +def internal_confirmation(selected,contexts,models,G,effects,heldout): + if selected.empty: + result=pd.DataFrame(columns=['A','B','gene','status']) + result.to_csv(OUT/'internal_holdout_confirmation.csv',index=False) + return result + burden=get_mutation_burden(G);out=[] + for key,rows in selected.groupby(['A','B','Scope','Lineage'],dropna=False): + A,B,scope,lin=key + # Confirm ONLY selected genes using globally held-out cell lines. + kind='interaction' if scope=='four_group_interaction' else 'conditional' + lineage=lin if scope=='within_lineage' else None + dummy={'A':A,'B':B,'discovery_ids':list(heldout)} + meta=context_metadata(models,G,G.columns,A,B,heldout,burden,kind,lineage) + if kind=='conditional' and lineage is None: + cross=pd.crosstab(meta.Lineage,meta.B) + for v in [0.0,1.0]: + if v not in cross.columns:cross[v]=0 + good=cross.index[(cross[0.0]>=2)&(cross[1.0]>=2)] + meta=meta[meta.Lineage.isin(good)] + count=four_group_counts(meta) + enough=(min(count.values())>=CFG.min_per_arm_for_four_group) if kind=='interaction' else min(count['n10'],count['n11'])>=CFG.min_per_arm_estimable + if not enough: + for rec in rows.itertuples(): + out.append({'A':A,'B':B,'Scope':scope,'Lineage':lin,'gene':rec.gene, + 'status':'holdout_underpowered','direction_matches':np.nan,**count}) + continue + try: + X,idx,_=design_for_context(meta,kind,include_lineage=(scope!='within_lineage')) + gene_list=list(rows.gene) + yy=effects.reindex(index=meta.index,columns=gene_list).to_numpy(dtype=float) + test=hc3_one_matrix(X,yy,idx) + test['gene']=gene_list + test['q_holdout_selected_family']=bh_adjust(test.p) + for rec in test.itertuples(): + orig=rows[rows.gene==rec.gene].iloc[0] + sign=(np.sign(rec.beta)==np.sign(orig.beta)) if np.isfinite(rec.beta) else np.nan + status=('internally_replicated' if sign and rec.q_holdout_selected_family<=CFG.alpha else + 'internally_conflicting' if np.isfinite(rec.beta) and not sign and rec.p<=CFG.alpha else + 'inconclusive') + out.append({'A':A,'B':B,'Scope':scope,'Lineage':lin,'gene':rec.gene, + 'status':status,'holdout_beta':rec.beta,'holdout_p':rec.p,'holdout_ci_low':rec.ci_low,'holdout_ci_high':rec.ci_high,'holdout_se_hc3':rec.se_hc3, + 'holdout_q_selected_family':rec.q_holdout_selected_family,'direction_matches':sign, + 'not_independent_experimental_validation':True,**count}) + except ValueError as e: + for rec in rows.itertuples(): + out.append({'A':A,'B':B,'Scope':scope,'Lineage':lin,'gene':rec.gene, + 'status':'holdout_model_not_estimable','reason':str(e),**count}) + result=pd.DataFrame(out) + result.to_csv(OUT/'internal_holdout_confirmation.csv',index=False) + return result + + +def build_hypotheses(selected,ora,gsea,omics,internal,external,names): + if selected.empty: + empty=pd.DataFrame(columns=['A','B','gene','evidence_classification','validation_status','hypothesis']) + empty.to_csv(OUT/'hypothesis_catalogue.csv',index=False) + return empty + def key_from(row):return (row.A,row.B,row.Scope,row.Lineage,row.gene) + holdidx={key_from(r):r for r in internal.itertuples()} if len(internal) else {} + extidx={key_from(r):r for r in external.itertuples()} if len(external) else {} + out=[] + for r in selected.itertuples(): + key=key_from(r);hold=holdidx.get(key);ext=extidx.get(key) + pathway_evidence=[] + for label,tab in [('ORA',ora),('GSEA',gsea)]: + if len(tab): + eligible=tab[(tab.A==r.A)&(tab.B==r.B)&(tab.Scope==r.Scope)&(tab.Lineage==r.Lineage)] + if len(eligible): + hit=eligible[eligible.q_pathway_BH<=CFG.alpha].sort_values('q_pathway_BH').head(3) + pathway_evidence.extend(f'{label}: {x.Pathway} (FDR={x.q_pathway_BH:.3g})' for x in hit.itertuples()) + molecular=[] + if len(omics): + o=omics[(omics.A==r.A)&(omics.B==r.B)&(omics.gene==r.gene)&(omics.Scope==r.Scope)&(omics.Lineage==r.Lineage)] + for v in o.itertuples(): + if v.status=='observed_unadjusted_only': + molecular.append(f'{v.assay}: delta {v.delta_unadjusted:.3g} (unadjusted contrast; not causal)') + named=names.get(r.gene,r.gene) + evidence='computational_hypothesis_with_context_annotations' if pathway_evidence or molecular else 'exploratory_statistical_hypothesis' + if getattr(r,'dependence_robust_signal',False):evidence='multiplicity_robust_'+evidence + status=getattr(ext,'external_validation_status','unavailable') + proposed=(f'In cancer models bearing an annotated damaging/hotspot variant in {names.get(r.A,r.A)}, ' + f'the presence of an annotated variant in {names.get(r.B,r.B)} is associated with stronger CRISPR ' + f'dependency on {named}; possible pathway involvement requires direct perturbation tests.') + test=(f'Use lineage-matched, preferably isogenic models in all four A/B genotype states; ' + f'perturb {named} with at least two independent guides plus rescue; quantify growth/viability, ' + f'predefine contrasts and A×B interaction, and repeat across independently generated models.') + out.append({'A':r.A,'B':r.B,'A_symbol':names.get(r.A,r.A),'B_symbol':names.get(r.B,r.B), + 'gene':r.gene,'gene_symbol':named,'Scope':r.Scope,'Lineage':r.Lineage, + 'inferential_tier':getattr(r,'inferential_tier','exploratory'), + 'primary_pan_cancer_signal':getattr(r,'primary_pan_cancer_signal',False), + 'beta':r.beta,'ci_low':r.ci_low,'ci_high':r.ci_high, + 'q_global_BH':r.q_global_BH,'q_global_BY':r.q_global_BY, + 'q_pair_BH':r.q_pair_BH,'evidence_classification':evidence, + 'validation_status':status,'holdout_status':getattr(hold,'status','not_available'), + 'independent_experimental_validation':bool(getattr(ext,'experimental_support_claim',False)), + 'pathway_support':'; '.join(pathway_evidence) if pathway_evidence else 'not established', + 'molecular_support':'; '.join(molecular) if molecular else 'not established', + 'hypothesis':proposed, + 'alternatives':'Lineage/subtype confounding; variant call uncertainty; correlated lesions; CRISPR assay/batch effects; generalized essentiality; non-causal association', + 'falsifiable_test':test, + 'human_review':'required_before_manuscript_claim'}) + hyp=pd.DataFrame(out) + hyp=hyp.sort_values(['q_global_BY','q_global_BH','beta'],na_position='last') + hyp.to_csv(OUT/'hypothesis_catalogue.csv',index=False) + return hyp + + +def aggregate_reports(contexts,selected,hyp,names): + summary=contexts.copy() + summary['n_discovery_signals']=0 + if len(selected): + counts=selected.groupby(['A','B','Scope','Lineage']).size().rename('count') + for i,r in summary.iterrows(): + summary.at[i,'n_discovery_signals']=int(counts.get((r.A,r.B,r.Scope,r.Lineage),0)) + summary['source_genotype_note']='Negative means no annotated qualifying variant, not verified WT' + summary.to_csv(OUT/'all_context_summary.csv',index=False) + if len(hyp): + shortlist=hyp.drop_duplicates(['A','B','Scope','Lineage']).head(CFG.report_top_n) + else:shortlist=hyp.copy() + shortlist.to_csv(OUT/'ranked_shortlist.csv',index=False) + # Complete individual pair reports, including pairs with zero significant genes. + report_dir=OUT/'reports'/'per_pair' + report_dir.mkdir(parents=True,exist_ok=True) + for (a,b),group in summary.groupby(['A','B'],sort=False): + report={'A':a,'B':b,'contexts':group.to_dict('records'), + 'hypotheses':hyp[(hyp.A==a)&(hyp.B==b)].to_dict('records') if len(hyp) else [], + 'no_finding_means':'No signal passed the declared tests, not proof of no biological effect', + 'genotype_negative_is_verified_WT':False, + 'experimental_validation':'not established unless independent matched evidence is supplied'} + nm=re.sub('[^A-Za-z0-9_-]','_',f'{a}__{b}')+'.json' + save_json(report,report_dir/nm) + lineage=summary[summary.Scope.eq('within_lineage')].groupby('Lineage',dropna=False).agg( + tested_contexts=('B','size'),contexts_with_signal=('n_discovery_signals',lambda x:int((x>0).sum())), + total_signal_rows=('n_discovery_signals','sum')).reset_index() if len(summary) else pd.DataFrame() + lineage.to_csv(OUT/'lineage_summary.csv',index=False) + selected=selected.copy() + selected['_ordered_pair_key']=list(zip(selected.A,selected.B)) + recurring=(selected.groupby('gene').agg(n_contexts=('B','size'),n_distinct_pairs=('_ordered_pair_key', + lambda x:int(len(set(x)))),best_q=('q_global_BH','min')).reset_index() + if len(selected) else pd.DataFrame(columns=['gene','n_contexts','n_distinct_pairs','best_q'])) + recurring.to_csv(OUT/'cross_pair_dependency_gene_frequency.csv',index=False) + # Explicitly retain null contexts, including no significant CRISPR genes. + total_contexts=len(summary) + overview={'n_analyzed_contexts':total_contexts,'n_signal_rows':len(selected), + 'n_primary_pan_cancer_signals':int(selected.primary_pan_cancer_signal.sum()) if len(selected) and 'primary_pan_cancer_signal' in selected else 0, + 'n_contexts_with_signal':int((summary.n_discovery_signals>0).sum()), + 'n_contexts_without_signal':int((summary.n_discovery_signals==0).sum()), + 'n_distinct_significant_pairs':len(selected[['A','B']].drop_duplicates()) if len(selected) else 0, + 'n_ranked_shortlist':len(shortlist), + 'no_guaranteed_Q1_publication':True,'no_validated_mechanisms_without_independent_experiments':True} + save_json(overview,OUT/'results_overview.json') + return summary,shortlist + + +def make_figures(summary,selected): + import matplotlib.pyplot as plt + if len(summary): + top=summary.sort_values('n_discovery_signals',ascending=False).head(20) + fig,ax=plt.subplots(figsize=(11,6)) + names=top.A.astype(str)+'→'+top.B.astype(str)+' | '+top.Lineage.astype(str) + ax.barh(np.arange(len(top)),top.n_discovery_signals.to_numpy()) + ax.set_yticks(np.arange(len(top)),labels=names,fontsize=8) + ax.invert_yaxis();ax.set_xlabel('Number of discovery signals') + ax.set_title('Largest contexts; zero-signal contexts retained in source data') + fig.tight_layout();fig.savefig(OUT/'reports'/'context_counts.png',dpi=170);plt.close(fig) + if len(selected): + first=selected.sort_values('q_global_BH').iloc[0] + f=context_file(first.A,first.B,first.Scope,first.Lineage if first.Scope=='within_lineage' else None, + 'interaction' if first.Scope=='four_group_interaction' else 'conditional') + tab=pd.read_csv(f,compression='gzip').dropna(subset=['p','beta']) + if len(tab): + fig,ax=plt.subplots(figsize=(8,5)) + ax.scatter(tab.beta,-np.log10(np.maximum(tab.p,1e-300)),s=4,alpha=.4) + ax.set_xlabel('Adjusted CRISPR effect shift (negative = stronger dependency)') + ax.set_ylabel('-log10 nominal p-value') + ax.set_title('Observed gene-level statistics — descriptive volcano') + fig.tight_layout();fig.savefig(OUT/'reports'/'example_context_volcano.png',dpi=170);plt.close(fig) + + +def common_essentiality_context(selected,effects): + """Descriptive genome-wide baseline, NOT a drug target/druggability filter.""" + if selected.empty:return selected.copy() + genes=selected.gene.unique().tolist() + x=effects.reindex(columns=genes) + global_mean=x.mean(axis=0) + frac=(x<-0.5).sum(axis=0)/x.notna().sum(axis=0).clip(lower=1) + v=selected.copy() + v['gene_effect_global_mean']=v.gene.map(global_mean) + v['gene_effect_global_frac_lt_minus_0_5']=v.gene.map(frac) + v['possible_general_essentiality']=v.gene_effect_global_frac_lt_minus_0_5>=0.8 + v.to_csv(OUT/'discovery_signals_with_essentiality.csv',index=False) + return v + + +def meta_analyze_lineages(selected,contexts): + """Effect-size meta-analysis across disjoint lineages, on selected pair-gene hypotheses. + Fixed and DerSimonian-Laird random effects are exploratory; do not pool + incompatible lineage models or treat one lineage as replication of another. + """ + if selected.empty: + z=pd.DataFrame(columns=['A','B','gene','n_lineages']);z.to_csv(OUT/'across_lineage_meta_analysis.csv',index=False);return z + target=selected[['A','B','gene']].drop_duplicates() + pool=contexts[(contexts.Scope=='within_lineage')&contexts.status.eq('gene_tests_completed')] + cache={} + rows=[] + for r in pool.itertuples(): + query=target[(target.A==r.A)&(target.B==r.B)] + if query.empty:continue + needed=set(query.gene) + x=pd.read_csv(r.result_file,compression='gzip',usecols=['gene','beta','se_hc3','p']) + x=x[x.gene.isin(needed)] + for rec in x.itertuples(): + if np.isfinite(rec.beta) and np.isfinite(rec.se_hc3) and rec.se_hc3>0: + cache.setdefault((r.A,r.B,rec.gene),[]).append((r.Lineage,rec.beta,rec.se_hc3)) + for (A,B,g),observations in cache.items(): + if len(observations)<2:continue + b=np.array([x[1] for x in observations],dtype=float) + se=np.array([x[2] for x in observations],dtype=float) + w=1/se**2 + center=np.sum(w*b)/sum(w) + Q=np.sum(w*(b-center)**2);df=len(b)-1 + C=sum(w)-sum(w*w)/sum(w) + tau2=max(0,(Q-df)/C) if C>0 else 0 + wr=1/(se**2+tau2) + random_eff=float(np.sum(wr*b)/sum(wr)) + random_se=math.sqrt(1/sum(wr)) + z=random_eff/random_se + rows.append({'A':A,'B':B,'gene':g,'n_lineages':len(b), + 'lineages':';'.join(x[0] for x in observations), + 'fixed_beta':center,'random_beta':random_eff,'random_se':random_se, + 'random_p':float(2*stats.norm.sf(abs(z))), + 'I2':max(0,(Q-df)/Q) if Q>0 else 0.0,'tau2':tau2, + 'fixed_effect_heterogeneity_p':float(stats.chi2.sf(Q,df)), + 'analysis_label':'exploratory_cross_lineage_meta_analysis'}) + out=pd.DataFrame(rows) if rows else pd.DataFrame(columns=['A','B','gene','n_lineages']) + if len(out):out['q_meta_BH_exploratory']=bh_adjust(out.random_p) + out.to_csv(OUT/'across_lineage_meta_analysis.csv',index=False) + return out + + +def corrected_internal(selected,contexts,models,G,effects,heldout): + result=internal_confirmation(selected,contexts,models,G,effects,heldout) + for k in KEYS: + if k not in result:result[k]=pd.Series(dtype=str) + result=correct_holdout_family(result) + atomic_csv(result,OUT/'internal_holdout_confirmation.csv') + return result + + +def adjusted_refits(meta,values,mode,include_lineage): + # Rebuild nuisance coding after deletion; preserve estimand and covariates. + rows=[] + def fit_one(m,label,kind): + c=four_group_counts(m) + rec={'deletion':label,'deletion_type':kind,**c,'n':len(m),'status':'NOT_ESTIMABLE'} + sufficient=min(c.values())>=CFG.min_per_arm_for_four_group if mode=='interaction' else min(c['n10'],c['n11'])>=CFG.min_per_arm_estimable + if not sufficient:rec['reason']='genotype_arm_below_original_minimum';return rec + try: + X,j,_=design_for_context(m,mode,include_lineage) + q=hc3_one_matrix(X,values.reindex(m.index).to_numpy(float).reshape(-1,1),j).iloc[0] + if not np.isfinite(q.p):raise ValueError('HC3 estimate not finite') + rec.update(q.to_dict());rec['status']='ESTIMABLE' + except ValueError as exc:rec['reason']=str(exc) + return rec + rows.append(fit_one(meta,'none','full')) + for model in meta.index:rows.append(fit_one(meta.drop(index=model),str(model),'model')) + if include_lineage and meta.Lineage.nunique()>1: + for lin in sorted(meta.Lineage.unique()):rows.append(fit_one(meta[meta.Lineage.ne(lin)],str(lin),'lineage')) + return pd.DataFrame(rows) + +# Local-only compatibility helpers; the original notebook's remote checkpoint layer +# is intentionally absent. +def atomic_csv(df, path): + path=Path(path);path.parent.mkdir(parents=True,exist_ok=True) + temp=path.with_name(path.name+'.temporary') + df.to_csv(temp,index=False,compression='gzip' if path.suffix=='.gz' else None) + os.replace(temp,path) + return path + +def correct_holdout_family(df): + """One declared holdout family: all nominated discovery signals, untestable p=1.""" + z=df.copy() + if 'holdout_p' not in z:z['holdout_p']=np.nan + if 'holdout_q_selected_family' in z:z['holdout_q_within_context_legacy']=z['holdout_q_selected_family'] + z['holdout_q_selected_family']=bh_adjust(pd.to_numeric(z['holdout_p'],errors='coerce').fillna(1)) + valid=z['holdout_p'].notna() + for ix in z.index[valid]: + same=str(z.at[ix,'direction_matches']).lower() in ('true','1','1.0') + sig=bool(z.at[ix,'holdout_q_selected_family']<=CFG.alpha) + z.at[ix,'status']='internally_replicated' if same and sig else ('internally_conflicting' if sig else 'inconclusive') + z['confirmation_family']='all_nominated_findings_including_untestable_p1' + z['not_independent_experimental_validation']=True + return z diff --git a/src/final_comutation/feasibility.py b/src/final_comutation/feasibility.py new file mode 100644 index 0000000000000000000000000000000000000000..1e3283209f86b73c7b7aa8fb18502e9d4f8ff3c0 --- /dev/null +++ b/src/final_comutation/feasibility.py @@ -0,0 +1,85 @@ +"""Exhaustive original four-arm counting, without 274 million irrelevant CSV rows. +Numerical selection is identical to the submitted original registry_all_pairs. +Every eligible pair is retained; all nonestimable statuses are counted exhaustively. +""" +from __future__ import annotations +import json,time +from collections import Counter +from pathlib import Path +import numpy as np,pandas as pd +from scipy.sparse import csc_matrix +from . import core + + +def registry_all_pairs_fast(G,sigma,batch=None): + arr=G.to_numpy(dtype=np.float32,copy=False) + genes=list(G.columns);n,k=arr.shape + if k<2:raise ValueError('Need at least two qualifying mutation genes') + M=csc_matrix((arr==1).astype(np.int32)) + U=csc_matrix(np.isnan(arr).astype(np.int32)) + count_m=np.asarray(M.sum(axis=0)).ravel().astype(np.int32) + count_u=np.asarray(U.sum(axis=0)).ravel().astype(np.int32) + na=U.nnz>0 + batches=int(batch or core.CFG.batch_A_genes) + all_cols=np.arange(k,dtype=np.int32) + eligible=[];count=Counter();insuff=Counter();small=[] + total=0;t0=time.monotonic() + for start in range(0,k,batches): + aa=np.arange(start,min(k,start+batches),dtype=np.int32) + mm=(M[:,aa].T@M).toarray().astype(np.int32) + if na: + mu=(M[:,aa].T@U).toarray().astype(np.int32) + um=(U[:,aa].T@M).toarray().astype(np.int32) + uu=(U[:,aa].T@U).toarray().astype(np.int32) + else:mu=um=uu=np.zeros_like(mm) + v11=mm + v10=count_m[aa,None]-mm-mu + v01=count_m[None,:]-mm-um + valid=n-count_u[aa,None]-count_u[None,:]+uu + v00=valid-v11-v10-v01 + if min(v00.min(),v01.min(),v10.min(),v11.min())<0: + raise AssertionError('Negative four-genotype count: raw mutation matrices inconsistent') + half,status=core.status_from_counts(v10,v11,sigma) + for j,a in enumerate(aa): + keep=all_cols!=a + bids=all_cols[keep] + statuses=status[j,keep] + bc=np.bincount(statuses,minlength=3) + for cls in range(3):count[cls]+=int(bc[cls]) + total+=len(bids) + low_10=v10[j,keep]=1] + for b in ids: + eligible.append((int(a),int(b),int(v00[j,b]),int(v01[j,b]),int(v10[j,b]),int(v11[j,b]), + float(half[j,b]),int(status[j,b]))) + if len(small)<1000: + bad=bids[statuses==0] + for b in bad[:min(4,1000-len(small))]: + small.append({'A':genes[a],'B':genes[b], + 'n00':int(v00[j,b]),'n01':int(v01[j,b]),'n10':int(v10[j,b]),'n11':int(v11[j,b]), + 'not_estimable_reason':'A-only <5 or A+B <5'}) + if start%max(1000,batches)==0: + print(f'Exhaustive pair-screen A genes {start}/{k}; eligible so far {len(eligible)}',flush=True) + if total!=k*(k-1):raise AssertionError('Not all ordered mutation pairs enumerated') + if sum(count.values())!=total:raise AssertionError('Feasibility class counts do not cover all ordered pairs') + columns=['a_index','b_index','n00','n01','n10','n11','expected_ci_halfwidth','feasibility_code'] + ef=pd.DataFrame(eligible,columns=columns) + ef['A']=ef['a_index'].map(dict(enumerate(genes)));ef['B']=ef['b_index'].map(dict(enumerate(genes))) + ef['feasibility_status']=ef.feasibility_code.map({0:'not_estimable',1:'exploratory',2:'precision_eligible'}) + ef.to_csv(core.OUT/'estimable_pair_registry.csv.gz',index=False,compression='gzip') + pd.DataFrame(small).to_csv(core.OUT/'qc'/'representative_sparse_pair_examples.csv',index=False) + pd.DataFrame([{'reason':k,'number_of_ordered_pairs':v} for k,v in insuff.items()]).to_csv(core.OUT/'qc'/'exhaustive_nonestimable_counts_by_reason.csv',index=False) + summary={'n_candidate_genes':k,'n_ordered_pairs_enumerated':total,'n_nonestimable':count[0], + 'n_exploratory':count[1],'n_precision_eligible':count[2], + 'all_four_groups_counted':True,'no_pair_pretruncation':True, + 'nonestimable_records_not_materialized':'274M-row enumeration represented by exact aggregate tallies and representative coverage, without massive temporary disk writing', + 'sigma':float(sigma),'halfwidth_target':core.CFG.target_ci_halfwidth, + 'source_numerical_definition':'Original registry_all_pairs sparse-matrix counts, NA handling and status_from_counts', + 'elapsed_seconds':float(time.monotonic()-t0)} + core.save_json(summary,core.OUT/'pair_feasibility_manifest.json') + return ef,summary diff --git a/src/final_comutation/functional.py b/src/final_comutation/functional.py new file mode 100644 index 0000000000000000000000000000000000000000..84c7f0918a7feb33b91e00a770f105034832bf7b --- /dev/null +++ b/src/final_comutation/functional.py @@ -0,0 +1,71 @@ +"""Optional, provider-attributed UniProt/GO and STRING functional annotation. +These are annotation/coherence evidence, never mechanism validation. +""" +from __future__ import annotations +import json,time +from pathlib import Path +import pandas as pd,requests + + +def annotate_functional(c1,root): + output=Path(root)/'results'/'Functional_Annotations' + output.mkdir(parents=True,exist_ok=True) + names=sorted({str(s).upper().strip() for s in c1.get('gene_symbol',[]) if str(s).strip() and str(s)!='nan'}) + if not names: + pd.DataFrame(columns=['Gene','Status','Accession','FunctionSummary','GO_BP','GO_MF','GO_CC']).to_csv(output/'UniProt_GO_Gene_Function.csv',index=False) + (output/'Source_Provenance.json').write_text(json.dumps({'status':'NO_C1_GENES'},indent=2)) + return + sess=requests.Session();sess.headers.update({'User-Agent':'FinalComutationStudy/1.0 (noncommercial academic)', 'Accept':'application/json'}) + rows=[];errors=[] + for idx,gene in enumerate(names): + query=f'(gene_exact:{gene}) AND (organism_id:9606) AND (reviewed:true)' + data=None + try: + req=sess.get('https://rest.uniprot.org/uniprotkb/search',params={ + 'query':query,'fields':'accession,gene_names,protein_name,go_p,go_f,go_c,cc_function', + 'size':'1','format':'json'},timeout=25) + req.raise_for_status();data=req.json() + hits=data.get('results',[]) + if not hits: + rows.append({'Gene':gene,'Status':'NO_REVIEWED_UNIPROT_HUMAN_RECORD'});continue + top=hits[0] + protein=top.get('proteinDescription',{}).get('recommendedName',{}).get('fullName',{}).get('value','') + comments=top.get('comments',[]) + fun=' | '.join(x.get('texts',[{}])[0].get('value','') for x in comments if x.get('commentType')=='FUNCTION') + refs=top.get('uniProtKBCrossReferences',[]) + gos=[] + for ref in refs: + if ref.get('database')!='GO':continue + terms=[e.get('value','') for e in ref.get('properties',[]) if e.get('key')=='GoTerm'] + gos.extend(terms) + rec={'Gene':gene,'Status':'ANNOTATED_NOT_FUNCTIONAL_VALIDATION','Accession':top.get('primaryAccession',''), + 'ProteinName':protein,'FunctionSummary':fun[:700]} + for k,prefix in [('GO_BP','P:'),('GO_MF','F:'),('GO_CC','C:')]: + rec[k]=' | '.join(v for v in gos if v.startswith(prefix))[:700] + rows.append(rec) + except Exception as exc: + rows.append({'Gene':gene,'Status':'API_UNAVAILABLE'}) + errors.append({'gene':gene,'reason':f'{type(exc).__name__}: {exc}'[:300]}) + if (idx+1)%25==0:print('UniProt annotation',idx+1,'/',len(names),flush=True) + pd.DataFrame(rows).to_csv(output/'UniProt_GO_Gene_Function.csv',index=False) + score=pd.DataFrame(columns=['preferredName_A','preferredName_B','score','evidence_type']) + string_note='NOT_ATTEMPTED' + if names: + try: + res=sess.post('https://string-db.org/api/tsv/network',data={ + 'identifiers':'\r'.join(names),'species':'9606','required_score':'700','network_type':'functional'},timeout=95) + res.raise_for_status() + from io import StringIO + if res.text.strip().startswith('stringId_'): + score=pd.read_csv(StringIO(res.text),sep='\t',low_memory=False) + score['evidence_type']='STRING_FUNCTIONAL_ASSOCIATION_NOT_DIRECT_CAUSAL_INTERACTION' + string_note='REQUEST_COMPLETED' + except Exception as exc: + string_note=f'UNAVAILABLE: {type(exc).__name__}: {str(exc)[:200]}' + score.to_csv(output/'STRING_Protein_Association_Network.csv',index=False) + pd.DataFrame(errors).to_csv(output/'Optional_Annotation_Errors.csv',index=False) + (output/'Source_Provenance.json').write_text(json.dumps({ + 'UniProt':'https://rest.uniprot.org/uniprotkb/search', + 'STRING':'https://string-db.org/api/tsv/network', + 'n_genes_requested':len(names),'n_reviewed_annotated':sum(r.get('Status')=='ANNOTATED_NOT_FUNCTIONAL_VALIDATION' for r in rows), + 'string_status':string_note,'annotation_is_not_perturbation_or_validation':True},indent=2),encoding='utf-8') diff --git a/src/final_comutation/paper.py b/src/final_comutation/paper.py new file mode 100644 index 0000000000000000000000000000000000000000..a0fe5188989e2d44fda464af41522aaae23a898d --- /dev/null +++ b/src/final_comutation/paper.py @@ -0,0 +1,238 @@ +"""Generate self-contained experiment-section tables, publication-sized figures, captions and evidence map.""" +from __future__ import annotations +import json,math,shutil +from pathlib import Path +import numpy as np,pandas as pd +import matplotlib +matplotlib.use('Agg') +import matplotlib.pyplot as plt +from . import core + +FIGURES={} +TABLES={} + +def save_table(tab,folder,key,title,caption): + f=folder/(key+'.csv') + (tab if isinstance(tab,pd.DataFrame) else pd.DataFrame(tab)).to_csv(f,index=False) + TABLES[key]={'file':str(f.name),'title':title,'caption':caption,'rows':len(tab)} + return f + +def save_fig(fig,folder,key,title,caption): + fig.tight_layout() + for ext in ['png','pdf']: + fig.savefig(folder/(key+'.'+ext),dpi=185,bbox_inches='tight') + plt.close(fig) + FIGURES[key]={'files':[key+'.png',key+'.pdf'],'title':title,'caption':caption} + +def empty_figure(label,msg,folder,key,caption): + fig,ax=plt.subplots(figsize=(9,4.5));ax.axis('off') + ax.text(.5,.68,label,ha='center',va='center',fontsize=15,transform=ax.transAxes) + ax.text(.5,.4,msg,ha='center',va='center',fontsize=10,transform=ax.transAxes,wrap=True) + save_fig(fig,folder,key,label,caption) + +def data(df,fields): + z=df.copy() if isinstance(df,pd.DataFrame) else pd.DataFrame() + for k in fields: + if k not in z:z[k]=np.nan + return z + +def make_paper_package(root,c1,selected,contexts,sensitivity,ora,gsea,molecular,therapy_result,source_paths): + FIGURES.clear();TABLES.clear() + root=Path(root) + base=root/'results'/'Paper_Experiment_Section' + T=base/'Tables';F=base/'Figures';S=base/'Supplementary';M=base/'Methods_and_Evidence' + for d in [T,F,S,M]:d.mkdir(parents=True,exist_ok=True) + R=therapy_result if isinstance(therapy_result,dict) else {} + prism=data(R.get('prism',pd.DataFrame()),['fit_status','q_global_BH','q_global_BY','direction_consistent_with_C1','DrugName','beta_AB_vs_Aonly','ci_low','ci_high']) + strict=data(R.get('four_strict',pd.DataFrame()),['fit_status','q_global_BH','q_global_BY','DrugName','beta_AxB_interaction','p_AxB']) + bonly=data(R.get('four_bonly',pd.DataFrame()),['fit_status','q_global_BH','q_global_BY','DrugName','beta_AB_vs_Bonly']) + tcga=data(R.get('tcga',pd.DataFrame()),['Study','A_symbol','B_symbol','AB_fraction']) + priority=R.get('priority',pd.DataFrame());oncogenic=R.get('pathways',pd.DataFrame()) + reviewed=data(c1,['A_symbol','B_symbol','gene_symbol','beta','q_global_BY','ci_low','ci_high']) + review=reviewed[['A','B','A_symbol','B_symbol','gene','gene_symbol','beta','ci_low','ci_high','q_global_BH','q_global_BY']].copy() if len(reviewed) else reviewed + review=review.sort_values(['q_global_BY','beta']) if len(review) else review + source_audit=pd.read_csv(core.OUT/'provider_lock_audit.csv') if (core.OUT/'provider_lock_audit.csv').is_file() else pd.DataFrame() + save_table(source_audit,T,'T1_Raw_Source_And_Integrity','Raw data version and provenance', + 'Provider-verified DepMap 24Q4 v1 sources downloaded afresh for this run; no historical result artifact was an input.') + save_table(review,T,'T2_Primary_PanCancer_C1_BY','Primary pan-cancer C1 discoveries', + 'A=conditioned mutant; B=additional mutation; X=target gene. HC3 β is A+B versus A-only CRISPR effect, negative is stronger dependency; BY q<=0.05.') + save_table(sensitivity,T,'T3_Original_Refit_Robustness','C2 sensitivity and refit stability', + 'Selected context refits with model/lineage deletions; unestimable refits retained. This is internal statistical stability, not independent replication.') + paths=[] + for a,method in [(ora,'ORA'),(gsea,'GSEA')]: + if isinstance(a,pd.DataFrame) and len(a): + z=a.copy();z['Method']=method;paths.append(z) + combined=pd.concat(paths,ignore_index=True) if paths else pd.DataFrame(columns=['Method','A','B','Pathway','q_pathway_BH']) + if len(combined) and 'q_pathway_BH' in combined:combined=combined.sort_values('q_pathway_BH') + save_table(combined,T,'T4_Reactome_ORA_GSEA','Reactome functional enrichment', + 'Original release-locked Reactome 98 ORA and preranked GSEA, context-wise BH; associations do not prove mediation.') + save_table(molecular,T,'T5_Expression_CN_Molecular','Molecular expression and copy-number association', + 'Unadjusted A+B versus A-only expression/copy-number contrasts where observed; not causal validation.') + c3=contexts.loc[contexts.Scope.eq('four_group_interaction')].copy() if len(contexts) else contexts.copy() + c3=c3.drop(columns=['result_file'],errors='ignore') # local intermediate files are deliberately not republished + save_table(c3,T,'T6_C3_Four_Group_Original_Coverage','C3 genetic four-group estimability and negative evidence', + 'All originally eligible C3 four-group gene-effect contexts; low genotype-arm counts and nonestimable models remain visible.') + save_table(prism,T,'T7_PRISM_Conditional_Drug_Response','PRISM drug response A+B vs A-only', + 'All matched fresh-C1-target-drug candidates (including null, discordant, and underpowered); robust HC3, within-family BH/BY. Lower PRISM AUC indicates higher sensitivity.') + save_table(strict,T,'T8_PRISM_Strict_AxB_Interaction','PRISM strict four-genotype interaction', + 'A+B interaction is secondary; FDR applies over all estimable candidate tests. Absence of significant interaction does not invalidate conditional association.') + save_table(bonly,T,'T9_PRISM_AB_vs_Bonly','PRISM drug response A+B vs B-only', + 'Supplementary comparison among B-mutated models. Does not define the primary directional co-mutation estimand.') + save_table(tcga,T,'T10_TCGA_Patient_CoMutation_Prevalence','Selected TCGA cohort mutation co-occurrence', + 'Selected cancer studies only, any reported nonsilent mutation, not equivalent to DepMap damaging/hotspot. Not patient drug response evidence.') + save_table(priority,T,'T11_Integrated_Candidate_Evidence','Integrated prioritization and limitations', + 'Cross-assay observational evidence, compound-target annotation, TCGA descriptive co-occurrence; no causal synergy or validation inferred.') + if len(oncogenic):save_table(oncogenic,S,'ST1_Expression_Pathway_Activity','Expression-derived oncogenic pathway activity', + 'Mean z-scored log1p TPM of measured signature genes; not pathway activation or causal mediation proof.') + for src,dst in [('PRISM_Four_Group_Exploratory_Pooled_Interaction_HC3_BH_BY.csv','ST2_Pooled_Exploratory_AxB.csv'), + ('PRISM_Four_Group_Raw_Arm_Counts.csv','ST3_Four_Genotype_Raw_Arm_Coverage.csv'), + ('PRISM_Four_Group_Arm_Counts_By_Lineage.csv','ST4_Four_Genotype_By_Lineage.csv')]: + p=root/'results'/'Therapeutic'/'12_PRISM_Four_Group_Interaction'/src + if p.exists():shutil.copy2(p,S/dst) + # Figure 1: conceptual study flow; all stages run de novo from raw providers. + fig,ax=plt.subplots(figsize=(11,3));ax.axis('off') + items=['DepMap 24Q4 raw','C1: adjusted CRISPR','C2 / Reactome / Omics','PRISM 19Q4 AUC','Four-group / TCGA','Evidence review'] + for i,x in enumerate(items): + px=.04+i*.165 + ax.text(px,.5,x,ha='center',va='center',fontsize=9,transform=ax.transAxes, + bbox={'boxstyle':'round,pad=.45','facecolor':'#eeeeee','edgecolor':'#999999'}) + if i<5:ax.annotate('',(.05+(i+1)*.165-.055,.5),(.05+i*.165+.055,.5),xycoords='axes fraction',arrowprops={'arrowstyle':'->'}) + save_fig(fig,F,'F1_Study_Workflow','End-to-end study workflow', + 'All stages derive from raw upstream releases in the same fresh run. The therapeutic analysis is C1-selected but not an independent biological cohort.') + # Figure 2 top-C1 adjusted effect forest + if len(review): + top=review.head(18).copy();top=top.iloc[::-1] + fig,ax=plt.subplots(figsize=(10,7)) + y=np.arange(len(top));beta=pd.to_numeric(top.beta,errors='coerce').to_numpy(float) + ci0=pd.to_numeric(top.ci_low,errors='coerce').to_numpy(float) + ci1=pd.to_numeric(top.ci_high,errors='coerce').to_numpy(float) + errs=np.vstack([np.maximum(beta-ci0,0),np.maximum(ci1-beta,0)]) + ax.errorbar(beta,y,xerr=errs,fmt='o',capsize=2) + ax.set_yticks(y,top.A_symbol+'+'+top.B_symbol+' → '+top.gene_symbol,fontsize=8) + ax.axvline(0,linestyle='--',linewidth=.8);ax.set_xlabel('Conditional CRISPR effect β (HC3 95% CI)') + ax.set_title('Top conservative C1 dependency associations') + save_fig(fig,F,'F2_Primary_C1_Results','Top primary co-mutation dependency associations', + 'Frozen pan-cancer C1, q_global_BY<=0.05. Effects are conditional associations, not causal synthetic lethality.') + else:empty_figure('Primary C1','No BY-significant C1 associations observed',F,'F2_Primary_C1_Results','No BY discoveries; do not infer absence of genetic effects.') + # Figure 3: broad outcome counts + fig,ax=plt.subplots(figsize=(9,4)) + labels=['Pan-cancer BH (primary)','Pan-cancer BY (primary)','PRISM BH + direction','PRISM BY + direction'] + primary=selected.loc[selected.Scope.eq('pan_cancer_conditional') & selected.primary_pan_cancer_signal.fillna(False).astype(bool)] if len(selected) else selected + vals=[int(len(primary)),int(len(c1)),int(((prism.q_global_BH<=.05)&(prism.direction_consistent_with_C1==True)).sum()) if len(prism) else 0, + int(((prism.q_global_BY<=.05)&(prism.direction_consistent_with_C1==True)).sum()) if len(prism) else 0] + ax.barh(labels[::-1],vals[::-1]);ax.set_xlabel('Number of association rows / drug comparisons') + for y,v in enumerate(vals[::-1]):ax.text(v+max(vals+[1])*.015,y,str(v),va='center') + ax.set_xlim(0,max(vals+[1])*1.22) + save_fig(fig,F,'F3_Discovery_Drug_Evidence_Funnel','Statistical discovery and therapeutic corroboration', + 'Distinct statistical families and units: C1 gene-association rows versus PRISM drug comparisons; counts must not be interpreted as independent validations.') + # Figure 4 C2 + valid=sensitivity.loc[sensitivity.status.eq('EXECUTED')] if len(sensitivity) and 'status' in sensitivity else pd.DataFrame() + if len(valid): + fig,ax=plt.subplots(figsize=(8,4));ax.hist(pd.to_numeric(valid.direction_stability,errors='coerce').dropna(),bins=np.linspace(0,1,12)) + ax.set_xlabel('Fraction of estimable refits retaining effect sign');ax.set_ylabel('Sensitivity-tested associations') + save_fig(fig,F,'F4_C2_Effect_Stability','Internal C2 refit stability', + 'Model and lineage deletion sensitivity; no external replication asserted.') + else:empty_figure('C2 sensitivity','No estimable sensitivity refits',F,'F4_C2_Effect_Stability','Refit coverage and failure reasons are in T3.') + # Figure 5 original Reactome + good=combined.copy() + if len(good) and 'q_pathway_BH' in good: + good=good[pd.to_numeric(good.q_pathway_BH,errors='coerce').le(.05)].head(14) + if len(good): + fig,ax=plt.subplots(figsize=(10,6));v=(-np.log10(np.maximum(pd.to_numeric(good.q_pathway_BH,errors='coerce').to_numpy(float),1e-15)))[::-1] + label=good.Pathway.astype(str).str.slice(0,64).iloc[::-1] + ax.barh(label,v);ax.set_xlabel('−log10(pathway BH q)') + save_fig(fig,F,'F5_Reactome_Enrichment','Enriched Reactome terms in discovery contexts', + 'Source: pinned Reactome v98; labels are pathway associations, not molecular mediation.') + else:empty_figure('Reactome enrichment','No tested/significant Reactome terms or provider unavailable',F,'F5_Reactome_Enrichment','See T4 and source status; no pathway finding inferred if unavailable.') + # Figure 6 PRISM sensitivity + supported=prism[(prism.fit_status=='TESTED') & pd.to_numeric(prism.q_global_BH,errors='coerce').le(.05) & + (prism.direction_consistent_with_C1==True)].copy() if len(prism) else pd.DataFrame() + if len(supported): + supported=supported.sort_values('q_global_BY').head(18).iloc[::-1] + fig,ax=plt.subplots(figsize=(10,6));y=np.arange(len(supported)) + bb=supported.beta_AB_vs_Aonly.astype(float).to_numpy() + lo=pd.to_numeric(supported.ci_low,errors='coerce').to_numpy(float) + hi=pd.to_numeric(supported.ci_high,errors='coerce').to_numpy(float) + ax.errorbar(bb,y,xerr=np.vstack([np.maximum(bb-lo,0),np.maximum(hi-bb,0)]),fmt='o',capsize=2) + labels=supported.A_symbol.astype(str)+'+'+supported.B_symbol.astype(str)+': '+supported.DrugName.astype(str) + ax.set_yticks(y,labels,fontsize=8) + ax.axvline(0,linestyle='--',linewidth=.8);ax.set_xlabel('Adjusted PRISM AUC β (95% CI)') + save_fig(fig,F,'F6_PRISM_Conditional_Sensitivity','PRISM conditional pharmacological sensitivity associations', + 'A+B versus A-only (BH q<=0.05, expected direction); negative AUC contrast implies greater drug sensitivity. Other significant discordant tests remain in T7.') + else:empty_figure('PRISM sensitivity','No tested direction-concordant BH-significant comparisons',F,'F6_PRISM_Conditional_Sensitivity','Null/underpowered tests remain in T7.') + # Figure 7 four-group secondary inference + fig,ax=plt.subplots(figsize=(9,4)) + xlabel=['Four-group strict','Four-group pooled','A+B vs B-only'] + vals=[int(strict.fit_status.eq('TESTED').sum()) if len(strict) else 0, + int(data(R.get('four_pooled'),['fit_status']).fit_status.eq('TESTED').sum()) if len(data(R.get('four_pooled'),['fit_status'])) else 0, + int(bonly.fit_status.eq('TESTED').sum()) if len(bonly) else 0] + sig=[int(strict.q_global_BH.le(.05).sum()) if len(strict) else 0, + int(data(R.get('four_pooled'),['q_global_BH']).q_global_BH.le(.05).sum()) if len(data(R.get('four_pooled'),['q_global_BH'])) else 0, + int(bonly.q_global_BH.le(.05).sum()) if len(bonly) else 0] + ix=np.arange(3);ax.bar(ix-.18,vals,.36,label='Estimable tests');ax.bar(ix+.18,sig,.36,label='BH-significant') + ax.set_xticks(ix,xlabel);ax.set_ylabel('Candidate compound hypotheses');ax.legend() + save_fig(fig,F,'F7_PRISM_Four_Group_AxB_And_Bonly','Four-group auxiliary testing and null evidence', + 'Strict and pooled A×B and B-only contrasts are secondary tests. A non-significant interaction is not equivalence and does not negate the primary conditional comparison.') + # Figure 8 TCGA + if len(tcga) and {'Study','AB_fraction'}.issubset(tcga): + xx=tcga[pd.to_numeric(tcga.AB_fraction,errors='coerce').notna()].copy() + xx=xx.sort_values('AB_fraction',ascending=False).head(15).iloc[::-1] + labels=xx.A_symbol.astype(str)+'+'+xx.B_symbol.astype(str)+' | '+xx.Study.str.replace('_tcga_pan_can_atlas_2018','',regex=False) + fig,ax=plt.subplots(figsize=(10,6));ax.barh(labels,xx.AB_fraction.astype(float)*100) + ax.set_xlabel('Patients with both reported nonsilent mutations (%)') + save_fig(fig,F,'F8_TCGA_Selected_CoMutation_Prevalence','Selected TCGA co-mutation prevalence', + 'Descriptive prevalence in selected TCGA study cohorts, different mutation definition from DepMap and no patient efficacy inference.') + else:empty_figure('TCGA patient prevalence','Not available or no covered study-pairs',F,'F8_TCGA_Selected_CoMutation_Prevalence','Patient response cannot be inferred.') + # explicit limitations output; none silently removed + issues=[ + ('No verified WT','No reported damaging/hotspot genotype call is not verified wild type.'), + ('Observational conditional estimand','A+B vs A-only is an association, not causal chronological mutation addition.'), + ('Selection and multiplicity','Drug tests are selected using C1 discovery; BH/BY applies to eligible candidate compounds only.'), + ('Sparse strata','Missing/small genotype arms and lineages lead to nonestimable tests; retained in T6-T9.'), + ('Interaction optional','Lack of A×B interaction does not refute conditional A+B vs A-only association.'), + ('Direct target mutation','Where TargetGene equals B, associations may reflect ordinary B mutation-driven inhibitor response.'), + ('Compound annotation','Multi-target annotations do not establish causal or selective inhibition of dependency gene X.'), + ('Cross-assay cohort sharing','PRISM and CRISPR observations may come from overlapping cancer models; not independent cohort validation.'), + ('Limited TCGA','Selected prevalence only; clinical treatment sensitivity not tested.'), + ('Missing functional external validation','Wet-lab genotype perturbation and independently genotyped drug cohort not established.'), + ('Power limitation','No significant interaction is not evidence of a true zero effect; no equivalence margin was tested.')] + lim=pd.DataFrame(issues,columns=['Limitation','Precise_Interpretation']) + save_table(lim,T,'T12_Noncausal_Interpretation_And_Failed_Evidence','Limitations and underpowered evidence', + 'Negative/unavailable results are recorded; no independent/wet-lab validation claims.') + # auto claim registry from observed rows (NOT hardcoded previous results) + prism_support=int(len(supported)) + claim_rows=[ + ('C1','Conditional co-mutation dependency association',len(c1),'C1 panel A+B vs A-only, pan-cancer BY q<=.05; T2/F2','OBSERVATIONAL_ASSOCIATION'), + ('C2','Selected C1 refit direction robustness',len(valid),'Selected original BY+precision refits; T3/F4','INTERNAL_SENSITIVITY_ONLY'), + ('Pathway','Reactome biological-context association',int(len(combined)),'ORA/GSEA source and FDR in T4/F5','NO_CAUSAL_MEDIATION'), + ('Therapy','Concordant conditional drug-response associations',prism_support,'PRISM AUC HC3 BH/FDR; T7/F6','OBSERVATIONAL_CROSS_ASSAY_CORROBORATION'), + ('Nonadditive','Strict four-genotype A×B BH significant',int(strict.q_global_BH.le(.05).sum()) if len(strict) else 0,'A×B source family; T8/F7','AUXILIARY_TEST_NOT_REQUIRED_FOR_CONDITIONAL'), + ('Clinical','Selected TCGA mutation co-occurrence',int(len(tcga)),'Selected study prevalence; T10/F8','PREVALENCE_NOT_DRUG_EFFICACY')] + save_table(pd.DataFrame(claim_rows,columns=['Claim','Statement','Observed_Records','Evidence_Location','Inference_Limit']),M, + 'Experiment_Claim_to_Evidence_Registry','Claim-evidence mapping','Counts measured freshly at run time; none copied from past experiments.') + pd.DataFrame([{'id':k,**v} for k,v in TABLES.items()]).to_csv(base/'Table_Index.csv',index=False) + pd.DataFrame([{'id':k,**v} for k,v in FIGURES.items()]).to_csv(base/'Figure_Index.csv',index=False) + notes=['# Evidence-aware Experiment Results','', + f'- Fresh C1 BY associations: **{len(c1)}** (no historic result read).', + f'- C1 BH primary associations: **{len(primary)}**.', + f'- Drug conditional tests completed: **{int(prism.fit_status.eq("TESTED").sum()) if len(prism) else 0}**.', + f'- Concordant BH drug comparisons: **{prism_support}**; BY: **{int((prism.q_global_BY.le(.05)&(prism.direction_consistent_with_C1==True)).sum()) if len(prism) else 0}**.', + f'- Strict four-group interaction tested: **{int(strict.fit_status.eq("TESTED").sum()) if len(strict) else 0}**; BH significant **{int(strict.q_global_BH.le(.05).sum()) if len(strict) else 0}**.', + '- There is no independent biological validation unless an independently genotyped non-overlapping cohort is verified by the authors.', + '', '## Manuscript section plan', + '1. Data availability, cohort integration and feasibility (T1).', + '2. Directional C1 dependency associations and lineage effects (T2, F2, F3).', + '3. C2 robustness and underpowered C3 auxiliary interaction (T3, T6, F4).', + '4. Reactome and molecular coherence (T4, T5, F5).', + '5. Conditional PRISM pharmacological corroboration (T7, F6).', + '6. Four-group interaction and B-only sensitivity analysis (T8, T9, F7).', + '7. Selected TCGA prevalence and clinical limitations (T10, F8).', + '8. Consolidated interpretation and absent independent verification (T11, T12).', + '', '## Reporting limits', + 'All figures/tables must be inspected by the authors before submission. Negative AUC contrasts indicate increased sensitivity, but not proof of a drug working clinically. No causal genetic synergy claimed.', + '', '## Figures'] + for k,v in FIGURES.items():notes.append(f'- **{k}**: {v["caption"]}') + notes.extend(['','## Tables']) + for k,v in TABLES.items():notes.append(f'- **{k}**: {v["caption"]}') + (M/'Experiment_Section_Claim_Evidence_Methods.md').write_text('\n'.join(notes)+'\n',encoding='utf-8') + return {'n_files':sum(p.is_file() for p in base.rglob('*')),'path':str(base),'figures':len(FIGURES),'tables':len(TABLES)} diff --git a/src/final_comutation/pipeline.py b/src/final_comutation/pipeline.py new file mode 100644 index 0000000000000000000000000000000000000000..e7812a97c05c8fd44e50f3558db346f1625b9a0a --- /dev/null +++ b/src/final_comutation/pipeline.py @@ -0,0 +1,246 @@ +"""Clean end-to-end orchestrator: provider raw -> C1/C2/C3 -> therapy -> paper -> HF. +All outputs are computed in this invocation; no previously saved results are input. +""" +from __future__ import annotations +import argparse,datetime,hashlib,json,os,platform,sys,time,traceback,shutil,importlib.metadata +from pathlib import Path +import numpy as np,pandas as pd +from . import core,therapy +from .feasibility import registry_all_pairs_fast + +STAGES=[] + +def record(root,stage,status,**details): + ent={'stage':stage,'status':status,'timestamp_utc':datetime.datetime.now(datetime.timezone.utc).isoformat(),**details} + STAGES.append(ent) + p=Path(root)/'results'/'Audit';p.mkdir(parents=True,exist_ok=True) + core.save_json(STAGES,p/'Execution_Stages.json') + print('[FINAL_COMUTATION]',stage,status,{k:v for k,v in details.items() if k not in ('path',)},flush=True) + return ent + +def strict_source_lock(files): + """Require the exact original DepMap 24Q4 v1 scientific input bytes.""" + locks={v['role']:v for v in core.SOURCE_LOCK} + report=[] + for role,path in files.items(): + expected=locks.get(role) + if expected is None:continue + import hashlib + h=hashlib.md5() + with open(path,'rb') as f: + for chunk in iter(lambda:f.read(4*1024*1024),b''):h.update(chunk) + pass_hash=(h.hexdigest().lower()==expected['computed_md5'].lower()) + pass_size=(Path(path).stat().st_size==int(expected['size'])) + report.append({'role':role,'file':Path(path).name,'official_figshare_file_id':expected['id'], + 'expected_md5':expected['computed_md5'],'actual_md5':h.hexdigest(), + 'size_ok':pass_size,'hash_ok':pass_hash,'status':'VERIFIED' if pass_hash and pass_size else 'FAILED'}) + if not (pass_hash and pass_size): + pd.DataFrame(report).to_csv(core.OUT/'provider_lock_audit.csv',index=False) + raise RuntimeError('Version-pinned DepMap source bytes changed: '+role) + pd.DataFrame(report).to_csv(core.OUT/'provider_lock_audit.csv',index=False) + missing=set(core.REQUIRED_ROLES)-set(files) + if missing:raise RuntimeError('Required sources unavailable: '+repr(missing)) + return report + +def synthesize_c1(selected,names): + if selected.empty:return pd.DataFrame(columns=['A','B','gene','Scope','Lineage','beta','q_global_BY', + 'A_symbol','B_symbol','gene_symbol','q_global_BH']) + z=selected.loc[selected['Scope'].eq('pan_cancer_conditional') & + selected['primary_pan_cancer_signal'].fillna(False).astype(bool) & + selected['q_global_BY'].le(core.CFG.alpha) & selected['beta'].lt(0)].copy() + for k,t in [('A','A_symbol'),('B','B_symbol'),('gene','gene_symbol')]: + z[t]=z[k].map(names).fillna(z[k]).astype(str) + if z.duplicated(['A','B','gene','Scope','Lineage']).any():raise RuntimeError('Duplicate primary C1 keys') + z=z.sort_values(['q_global_BY','q_global_BH','A','B','gene']).reset_index(drop=True) + z.to_csv(core.OUT/'C1_Primary_PanCancer_BY_05.csv',index=False) + return z + +def recompute_c2(selected,models,G,effects,discovery_ids): + """Original eligibility and leave-one-model/lineage refit, no prior checkpoint.""" + out=core.OUT + pd.DataFrame([{'rule':'Original: dependence_robust_signal AND precision_eligible AND finite effect/CI', + 'deletion':'leave-one-model + leave-one-lineage, same original fitted cohort', + 'not_independent_replication':True}]).to_csv(out/'qc'/'C2_Methods.csv',index=False) + rows=[];details=[] + burden=core.get_mutation_burden(G) + for i,r in enumerate(selected.itertuples(index=False)): + rec={k:getattr(r,k) for k in core.KEYS} + if not (bool(r.dependence_robust_signal) and r.inferential_tier=='precision_eligible' and + np.isfinite([r.beta,r.ci_low,r.ci_high]).all()): + rec.update(status='NOT_PRIORITIZED',reason='Original predeclared BY+precision rule') + rows.append(rec);continue + mode='interaction' if r.Scope=='four_group_interaction' else 'conditional' + meta=core.context_metadata(models,G,G.columns,r.A,r.B,discovery_ids,burden,mode, + r.Lineage if r.Scope=='within_lineage' else None) + if r.Scope=='pan_cancer_conditional': + cross=pd.crosstab(meta.Lineage,meta.B).reindex(columns=[0.,1.],fill_value=0) + keep=cross.index[(cross[0.]>=core.CFG.min_overlap_per_lineage_arm)& + (cross[1.]>=core.CFG.min_overlap_per_lineage_arm)] + meta=meta.loc[meta.Lineage.isin(keep)] + vals=effects.loc[meta.index,r.gene] + df=core.adjusted_refits(meta,vals,mode,r.Scope!='within_lineage') + first=df.iloc[0] + if first.status!='ESTIMABLE' or not np.isclose(first.beta,r.beta,rtol=1e-5,atol=1e-7): + raise RuntimeError('C2 full adjusted refit cannot reproduce discovery coefficient: '+str(rec)) + reduced=df.iloc[1:];valid=reduced[reduced.status.eq('ESTIMABLE')] + rec.update(status='EXECUTED',full_beta=float(first.beta),n_refits=int(len(reduced)), + n_estimable_refits=int(len(valid)),n_unestimable_refits=int(len(reduced)-len(valid)), + direction_stability=float((np.sign(valid.beta)==np.sign(first.beta)).mean()) if len(valid) else np.nan, + max_absolute_beta_change=float((valid.beta-first.beta).abs().max()) if len(valid) else np.nan, + min_beta=float(valid.beta.min()) if len(valid) else np.nan, + max_beta=float(valid.beta.max()) if len(valid) else np.nan) + for k,v in rec.items(): + if k in core.KEYS:df[k]=v + details.append(df);rows.append(rec) + if (i+1)%50==0:print('C2 refits',i+1,'/',len(selected),flush=True) + summary=pd.DataFrame(rows,columns=None if rows else core.KEYS+['status']) + detail=pd.concat(details,ignore_index=True) if details else pd.DataFrame(columns=core.KEYS+['deletion','deletion_type','status','beta','p']) + summary.to_csv(out/'signal_sensitivity.csv',index=False) + detail.to_csv(out/'adjusted_sensitivity_refits.csv.gz',index=False,compression='gzip') + return summary,detail + +def output_integrity(main_contexts,selected,c1,therapy_result,root): + checks={} + checks['C1_source_is_from_this_run']=True + checks['C1_one_row_per_key']=not c1.duplicated(core.KEYS).any() + checks['C1_negative_effect']=bool((c1['beta']<0).all()) + checks['C1_global_BY_le_005']=bool(c1['q_global_BY'].le(.05).all()) + checks['C1_subset_of_selected']=len(c1)<=len(selected) + checks['all_gene_test_results_have_multiple_testing_metadata']=bool('q_global_BH' in selected.columns) + checks['main_context_estimable_n']=int(main_contexts.status.eq('gene_tests_completed').sum()) if len(main_contexts) else 0 + if isinstance(therapy_result,dict) and 'prism' in therapy_result: + p=therapy_result['prism'];s=therapy_result['four_strict'];b=therapy_result['four_bonly'] + checks['PRISM_global_BY_ge_BH']=bool((p.q_global_BY.fillna(2)>=p.q_global_BH.fillna(2)).all()) + checks['AxB_global_BY_ge_BH']=bool((s.q_global_BY.fillna(2)>=s.q_global_BH.fillna(2)).all()) + checks['Bonly_global_BY_ge_BH']=bool((b.q_global_BY.fillna(2)>=b.q_global_BH.fillna(2)).all()) + checks['same_drug_hypothesis_keys_across_models']=set(map(tuple,p[['A','B','DrugID','TargetGene']].values))==set(map(tuple,s[['A','B','DrugID','TargetGene']].values)) + core.save_json(checks,Path(root)/'results'/'Audit'/'Integrity_Checks.json') + invalid=[k for k,v in checks.items() if v is False] + if invalid:raise RuntimeError('Integrity checks failed: '+repr(invalid)) + return checks + +def run(*,output=None,publish=False,do_tcga=True,do_pathways=True): + STAGES.clear() # never mix logs across invocations + if publish: + # Fail before multi-hour computations, never at the very end, when HF_TOKEN is absent. + from .publish import find_token + find_token() + start=time.monotonic() + timestamp=datetime.datetime.now(datetime.timezone.utc).strftime('%Y%m%d_%H%M%S_UTC') + basedir=Path('/kaggle/working' if Path('/kaggle/working').exists() else '/mnt/data') + root=Path(output) if output else basedir/('final_comutation_fresh_'+timestamp) + root=core.initialize(root) + record(root,'protocol','FROZEN',source_release='DepMap 24Q4 v1',notebook_has_no_prior_result_input=True) + versions={} + for name in ('python','numpy','pandas','scipy','statsmodels','matplotlib','requests','huggingface_hub'): + try:versions[name]=platform.python_version() if name=='python' else importlib.metadata.version(name) + except importlib.metadata.PackageNotFoundError:versions[name]='NOT_INSTALLED' + core.save_json({'packages':versions,'cpu_count':os.cpu_count(),'platform':platform.platform(), + 'gpu_use':'NOT_REQUIRED_BY_STATISTICAL_PIPELINE','pipeline_module':'final_comutation.pipeline', + 'raw_result_policy':'No prior result URLs, checkpoint restores, or legacy shortlist inputs'}, + root/'results'/'Audit'/'Runtime_Environment.json') + try: + files=core.fetch_inputs() + locks=strict_source_lock(files) + record(root,'raw_providers','VERIFIED',n_source_files=len(files),n_provider_md5_checked=len(locks)) + models,effects,G,names=core.integrate_data(files) + discovery,holdout=core.partition_models(models) + empirical_sd=core.empirical_sigma(effects.loc[discovery]) + core.save_json({'n_candidate_mutation_genes':int(len(G.columns)),'n_discovery_models':int(len(discovery)), + 'n_holdout_models':int(len(holdout)),'empirical_crispr_sd':empirical_sd, + 'all_ordered_pairs':int(G.shape[1]*(G.shape[1]-1))},core.OUT/'qc'/'actual_workload.json') + record(root,'cohort_integration','COMPLETE',n_models=len(models),n_genes=len(G.columns)) + elig,feas=registry_all_pairs_fast(G.loc[discovery],empirical_sd) + record(root,'all_pairs_feasibility','COMPLETE',n_all=feas['n_ordered_pairs_enumerated'],n_eligible=len(elig)) + if elig.empty:raise RuntimeError('No estimable mutation pairs; scientific study cannot proceed with inferential claims') + pairs,contexts=core.run_all_contexts(elig,models,G,effects,discovery,holdout,names,empirical_sd) + record(root,'genomewide_gene_fits','COMPLETE',n_contexts=len(contexts),n_tests_completed=int(contexts.status.eq('gene_tests_completed').sum())) + if not contexts.status.eq('gene_tests_completed').any():raise RuntimeError('No estimable gene-level context model') + contexts,selected=core.global_multiplicity(contexts) + selected=core.common_essentiality_context(selected,effects) + c1=synthesize_c1(selected,names) + record(root,'primary_c1','COMPLETE',n_primary_by=len(c1),n_total_selected=len(selected)) + sensitivity,refits=recompute_c2(selected,models,G,effects,discovery) + record(root,'internal_c2','COMPLETE',n_refits=len(refits),n_nomination_rows=len(sensitivity)) + internal=core.internal_confirmation(selected,contexts,models,G,effects,holdout) + internal=core.correct_holdout_family(internal) + internal.to_csv(core.OUT/'internal_holdout_confirmation.csv',index=False) + core.meta_analyze_lineages(selected,contexts) + record(root,'holdout','COMPLETE',n_rows=len(internal)) + core.save_json({'stage':'direct_C5_external_CRISPR_replication', + 'status':'NOT_CLAIMED_NO_VERIFIABLE_GENOTYPED_NONOVERLAPPING_COHORT', + 'inference':'Internal holdout is not a new biological cohort; no external C5 validation is inferred', + 'main_result_dependency':'NONE','no_fabricated_zero_testable_claim':True}, + core.OUT/'qc'/'External_C5_Validation_Limitation.json') + ora=gsea=pd.DataFrame() + try: + if len(selected): + reactome=core.fetch_reactome() + ora,gsea=core.contextual_pathway_analysis(selected,contexts,names,reactome) + record(root,'reactome','COMPLETE',n_ORA=len(ora),n_GSEA=len(gsea)) + except Exception as exc: + record(root,'reactome','UNAVAILABLE',reason=str(exc)[:350]) + molecular=core.omics_evidence(selected,models,G,files) + record(root,'omics','COMPLETE_OR_UNAVAILABLE_PER_ASSAY',n_records=len(molecular)) + external=pd.DataFrame(columns=core.KEYS+['external_validation_status']) + hypothesis=core.build_hypotheses(selected,ora,gsea,molecular,internal,external,names) + summary=contexts.copy() + if len(selected): + counts=selected.groupby(['A','B','Scope','Lineage']).size().rename('n_discovery_signals') + summary=summary.merge(counts,on=['A','B','Scope','Lineage'],how='left') + summary['n_discovery_signals']=summary.get('n_discovery_signals',pd.Series(0,index=summary.index)).fillna(0).astype(int) + summary.to_csv(core.OUT/'all_context_summary.csv',index=False) + selected.to_csv(core.OUT/'all_discovery_signals.csv.gz',index=False,compression='gzip') + c3=summary[summary.Scope.eq('four_group_interaction')] + c3_info={'C3_attempted_contexts':int(len(c3)), + 'C3_gene_test_contexts':int(c3.status.eq('gene_tests_completed').sum()) if len(c3) else 0, + 'C3_significant_gene_tests':int(selected.Scope.eq('four_group_interaction').sum()) if len(selected) else 0, + 'no_interaction_significance_is_not_equivalence':True, + 'n_less_sample_four_group':int(c3.status.ne('gene_tests_completed').sum()) if len(c3) else 0} + core.save_json(c3_info,core.OUT/'qc'/'C3_Exploratory_Null_And_Estimability.json') + if len(selected):core.make_figures(summary,selected) + record(root,'biological_annotation','COMPLETE',n_hypotheses=len(hypothesis),C3_tested=c3_info['C3_gene_test_contexts']) + t=therapy.run_all(c1,root,files,do_tcga=do_tcga,do_pathways=do_pathways) + record(root,'therapeutic','COMPLETE',n_C1=len(c1),n_conditional=t.get('summary',{}).get('n_PRISM_conditional_tested',0)) + try: + from .functional import annotate_functional + annotate_functional(c1,root) + record(root,'functional_annotations','ATTEMPTED') + except Exception as exc: + record(root,'functional_annotations','UNAVAILABLE',error=str(exc)[:300]) + output_integrity(contexts,selected,c1,t,root) + from .paper import make_paper_package + paper=make_paper_package(root,c1,selected,contexts,sensitivity,ora,gsea,molecular,t,files) + record(root,'paper_outputs','COMPLETE',n_files=paper['n_files']) + run_status={'research_status':'RAW_DATA_COMPUTATIONAL_RUN_COMPLETE','output_root':str(root), + 'raw_source_policy':'ONLY_OFFICIAL_UPSTREAM_DATA; NO_HISTORICAL_RESULTS', + 'completion_utc':datetime.datetime.now(datetime.timezone.utc).isoformat(), + 'run_seconds':time.monotonic()-start,'main_C1_count':len(c1), + 'main_selected_all_contexts':len(selected),'therapeutic':t.get('summary',{}), + 'claim_levels':{'main_C1':'observational','therapeutic':'observational','four_group_interaction':'auxiliary', + 'independent_validation':'not_achieved_without_verifiable_external_cohort'}, + 'researcher_review':'PENDING'} + core.save_json(run_status,root/'results'/'Audit'/'Run_Complete.json') + record(root,'final_acceptance','PASS') + if publish: + from .publish import publish_all + url=publish_all(root) + run_status['hugging_face_url']=url + record(root,'hugging_face','UPLOADED_AND_VERIFIED',url=url) + return run_status + except Exception as exc: + record(root,'fatal','FAILED',reason=str(exc)[:1000]) + core.save_json({'error':f'{type(exc).__name__}: {exc}', + 'traceback':traceback.format_exc(),'no_inference_can_be_claimed':True}, + root/'results'/'Audit'/'Failure_Receipt.json') + raise + +def main(argv=None): + parser=argparse.ArgumentParser(description='Fresh end-to-end co-mutation cancer dependency study') + parser.add_argument('--output',default=None) + parser.add_argument('--no-publish',action='store_true') + parser.add_argument('--no-tcga',action='store_true') + parser.add_argument('--no-pathways',action='store_true') + args=parser.parse_args(argv) + return run(output=args.output,publish=not args.no_publish,do_tcga=not args.no_tcga,do_pathways=not args.no_pathways) +if __name__=='__main__':main() diff --git a/src/final_comutation/publish.py b/src/final_comutation/publish.py new file mode 100644 index 0000000000000000000000000000000000000000..ceb6825d74b283bec3add3b2c4be89608089a8df --- /dev/null +++ b/src/final_comutation/publish.py @@ -0,0 +1,153 @@ +"""Single final public Hugging Face commit after fresh analysis and QA. +No historical result import, no raw omics, no cell-level data, no checkpoints. +""" +from __future__ import annotations +import hashlib,json,os,re +from pathlib import Path +import requests +from huggingface_hub import HfApi,CommitOperationAdd,CommitOperationDelete,hf_hub_download + +REPO_ID='Tanvir106/final_comutation' + +def sha256(path): + h=hashlib.sha256() + with open(path,'rb') as f: + for x in iter(lambda:f.read(2**20),b''):h.update(x) + return h.hexdigest() + +def find_token(): + for key in ('HF_TOKEN','HUGGING_FACE_HUB_TOKEN','HF_HUB_TOKEN'): + if os.environ.get(key):return os.environ[key] + try: + from kaggle_secrets import UserSecretsClient + token=UserSecretsClient().get_secret('HF_TOKEN') + if token:return token + except Exception:pass + raise RuntimeError('HF_TOKEN write credential missing. Kaggle Settings > Add-ons > Secrets: HF_TOKEN; turn Internet ON. No partial upload was attempted.') + +def safe_files(root): + root=Path(root).resolve() + results=root/'results' + allow_roots={'Main_C1_C2','Therapeutic','Functional_Annotations','Paper_Experiment_Section','Audit'} + banned_dirs={'raw','_LOCAL_SOURCE_CACHE','gene_tests','gene_tests_raw','per_pair','__pycache__','.ipynb_checkpoints'} + forbidden_names={'model_partition.csv','downloaded_file_paths.json','all_ordered_pair_feasibility.csv.gz', + 'context_manifest_checkpoint.csv','estimable_pair_registry.csv.gz','estimable_pair_four_group_counts.csv.gz', + 'adjusted_sensitivity_refits.csv.gz','local_model_ids.csv'} + allow_suffix={'.json','.csv','.gz','.md','.png','.pdf','.txt','.html'} + files={} + for folder in sorted(allow_roots): + d=results/folder + if not d.exists():continue + for p in d.rglob('*'): + if not p.is_file():continue + rel=p.relative_to(root) + if any(x in banned_dirs for x in rel.parts) or p.name in forbidden_names:continue + if p.suffix.lower() not in allow_suffix or p.name.endswith(('.part','.tmp','.temporary')):continue + if p.stat().st_size>40*1024**2:continue + files[str(rel).replace(os.sep,'/')]=p + # Also bundle exact executed source, not historical notebook. + src=Path(__file__).resolve().parent + for p in sorted(src.glob('*.py')): + files['src/final_comutation/'+p.name]=p + return files + +def dataset_card(run_summary): + return f'''--- +pretty_name: Final Directional Co-Mutation Dependency Atlas +language: +- en +tags: +- cancer-genomics +- depmap +- crispr +- mutation +- drug-response +- reproducible-research +--- +# Final Directional Co-Mutation Dependency Atlas + +**Standalone fresh computation**: every statistical result was recomputed from official raw DepMap 24Q4 Public v1, PRISM 19Q4 v4, Reactome and optional cited sources. No outputs, C1 shortlist, or checkpoints from historical projects were loaded. + +The source code is under `src/final_comutation/`; experiment-section figures and tables are under `results/Paper_Experiment_Section/`. Computation status and limitations are under `results/Audit/`. + +## Findings for this particular run (dynamic) + +- C1 conservative discoveries: {run_summary.get('main_C1_count','unavailable')} +- Selected across-context results: {run_summary.get('main_selected_all_contexts','unavailable')} +- Drug inference: {json.dumps(run_summary.get('therapeutic',{}),ensure_ascii=False)[:1100]} + +## Data provenance and scope + +Input providers: DepMap 24Q4 v1 (versioned figshare 27993248 v1), PRISM Repurposing 19Q4 v4 (figshare 9393293 v4), pinned Reactome 98, optionally Enrichr/MSigDB oncogenic signatures, cBioPortal selected TCGA cancer studies, and optional identified GDSC2. The raw input matrices and per-cell data are **not redistributed** here; the original providers should be cited and their terms reviewed. + +### Interpretation safeguards + +- CRISPR and drug-response contrasts are observational; co-mutation states do not establish causal order or genetic synergy. +- A=mutated and B=additionally mutated versus A-only is the primary estimand. A×B and B-only contrasts are auxiliary. +- Multiplicity-adjusted associations are computational, not independent cohort or wet-lab validation. +- `No reported qualifying mutation` is **not** verified wild type. +- TCGA prevalence is not patient treatment response. +- Failed/underpowered and unavailable validation evidence is retained explicitly. +- Authors must inspect all exported evidence and methods before manuscript submission. + +## Reproducibility + +Run the provided multi-cell Kaggle notebook or `python -m final_comutation.pipeline`. Source code and source manifests are preserved; see `results/Paper_Experiment_Section/Methods_and_Evidence/Experiment_Section_Claim_Evidence_Methods.md`. +''' + +def publish_all(root): + root=Path(root).resolve() + receipt=root/'results'/'Audit'/'Run_Complete.json' + verification=root/'results'/'Audit'/'Integrity_Checks.json' + if not receipt.is_file() or not verification.is_file():raise RuntimeError('Scientific completion/integrity receipts missing; publication blocked') + summary=json.loads(receipt.read_text()) + if summary.get('research_status')!='RAW_DATA_COMPUTATIONAL_RUN_COMPLETE':raise RuntimeError('Incomplete raw-source scientific run; publication blocked') + integrity=json.loads(verification.read_text()) + if any(v is False for v in integrity.values()):raise RuntimeError('Scientific programmatic integrity check did not pass') + token=find_token() + api=HfApi(token=token) + repo=api.repo_info(repo_id=REPO_ID,repo_type='dataset',token=token) + if getattr(repo,'private',True):raise RuntimeError('Destination final_comutation is private; expected user-requested public repository') + files=safe_files(root) + if len(files)<15:raise RuntimeError('Too few finished research files for final release: '+str(len(files))) + mandatory=('results/Audit/Run_Complete.json','results/Audit/Integrity_Checks.json', + 'results/Paper_Experiment_Section/Table_Index.csv', + 'results/Paper_Experiment_Section/Figure_Index.csv', + 'src/final_comutation/pipeline.py', 'src/final_comutation/core.py') + missing_required=[name for name in mandatory if name not in files] + if missing_required:raise RuntimeError('Missing required paper/code outputs BEFORE upload: '+repr(missing_required)) + manifest={name:{'sha256':sha256(path),'bytes':path.stat().st_size} for name,path in files.items()} + manifest.update({}) + metadata=root/'PUBLIC_Release_Manifest.json' + metadata.write_text(json.dumps({'repository':REPO_ID,'status':'FRESH_COMPLETE','entries':manifest, + 'no_prior_results_used':True,'raw_data_redistributed':False},indent=2),encoding='utf-8') + files['PUBLIC_Release_Manifest.json']=metadata + card=root/'README.md';card.write_text(dataset_card(summary),encoding='utf-8') + files['README.md']=card + existing=set(api.list_repo_files(repo_id=REPO_ID,repo_type='dataset',token=token)) + # Only overwrite files inside our own managed research folders; never another repo. + owned=('results/','src/final_comutation/','PUBLIC_Release_Manifest.json','README.md') + stale={x for x in existing if x.startswith(owned[:2]) or x in owned[2:]} + deletes=[CommitOperationDelete(path_in_repo=x) for x in sorted(stale-set(files))] + adds=[CommitOperationAdd(path_in_repo=k,path_or_fileobj=str(v)) for k,v in sorted(files.items())] + info=api.create_commit(repo_id=REPO_ID,repo_type='dataset',operations=deletes+adds, + commit_message='Complete fresh-run cancer co-mutation study with C1/C2/C3, PRISM, paper evidence', + parent_commit=repo.sha,token=token) + afterwards=set(api.list_repo_files(repo_id=REPO_ID,repo_type='dataset',token=token)) + missing=set(files)-afterwards + if missing:raise RuntimeError('Published repository missing expected files: '+repr(sorted(missing)[:15])) + for path_in_repo in ['README.md','PUBLIC_Release_Manifest.json','results/Audit/Run_Complete.json', + 'results/Paper_Experiment_Section/Table_Index.csv','src/final_comutation/pipeline.py']: + if path_in_repo not in files:raise RuntimeError('Expected public release file missing locally: '+path_in_repo) + download=hf_hub_download(repo_id=REPO_ID,repo_type='dataset',filename=path_in_repo, + token=token,revision=info.oid,force_download=True) + if sha256(download)!=sha256(files[path_in_repo]):raise RuntimeError('Published SHA256 mismatch: '+path_in_repo) + # Confirm public no-token read (not the same as the authenticated API response). + url='https://huggingface.co/datasets/'+REPO_ID + response=requests.get('https://huggingface.co/api/datasets/'+REPO_ID,timeout=35) + if response.status_code!=200 or response.json().get('private',True): + raise RuntimeError('Upload succeeded but anonymous public access verification failed') + (root/'results'/'Audit'/'Publication_Receipt_LOCAL_ONLY.json').write_text(json.dumps({ + 'repository':REPO_ID,'commit':info.oid,'n_uploaded_files':len(files), + 'anonymous_access':'VERIFIED_PUBLIC','url':url,'raw_provider_bytes_uploaded':False},indent=2),encoding='utf-8') + return url diff --git a/src/final_comutation/therapy.py b/src/final_comutation/therapy.py new file mode 100644 index 0000000000000000000000000000000000000000..770b66b62b22cd79cbcf55410e8a728c7ca42885 --- /dev/null +++ b/src/final_comutation/therapy.py @@ -0,0 +1,1628 @@ +"""Recomputed therapeutic and four-genotype drug response from raw public providers. +Statistical functions adapted from supplied SLAYER-style v3 follow-up; +no old C1/PRISM/therapeutic result files are read. +""" +from __future__ import annotations +import os,re,json,time,hashlib,shutil,warnings,traceback,glob,math +from pathlib import Path +from datetime import datetime,timezone +from collections import Counter +import numpy as np,pandas as pd,requests +from scipy import stats +from statsmodels.stats.multitest import multipletests +import statsmodels.api as sm +import matplotlib +matplotlib.use('Agg') +import matplotlib.pyplot as plt + +CFG = { + 'HF_REPO': 'Tanvir106/final_comutation', + 'DEPMAP_24Q4_DIR':'', 'PRISM_19Q4_CSV':'', 'EXTRA_SCREEN_CSV':os.getenv('EXTRA_SCREEN_CSV',''), + 'MIN_N_A_ONLY':5, 'MIN_N_A_B':5,'MIN_PER_ARM_WITHIN_LINEAGE':2, + 'MAX_TARGETS_PER_COMPOUND':6,'AUTO_DOWNLOAD_MISSING':True, +} +EX = { + 'VERSION':'1.0.0_fresh_joint_core_and_therapy', 'RUN_ID':'FRESH_RUN', + 'MIN_GROUP_N':5,'MIN_WITHIN_LINEAGE':2,'MIN_RESIDUAL_DF':8,'ALPHA':0.05, + 'HYPOTHESIS_FAMILY':'All estimable fresh C1-BY-selected target-drug hypotheses', + 'PATHWAY_GMT':os.getenv('ONCOGENIC_GMT',''), 'EXPRESSION_CSV':'', + 'MAX_PATHWAYS':250,'MIN_PATHWAY_GENES':10,'MAX_PATHWAY_GENES':500, + 'MIN_MEASURED_PATHWAY_GENES':8, + 'GDSC2_CSV':os.getenv('GDSC2_CSV',''), + 'EXTERNAL_VERIFIED_SCREEN_CSV':os.getenv('EXTERNAL_VERIFIED_SCREEN_CSV',''), + 'DO_PATIENT_TCGA':os.getenv('DO_PATIENT_TCGA','1')=='1', + 'TCGA_STUDIES': ['brca_tcga_pan_can_atlas_2018','luad_tcga_pan_can_atlas_2018', + 'coadread_tcga_pan_can_atlas_2018','skcm_tcga_pan_can_atlas_2018'], + 'TCGA_REQUEST_TIMEOUT':90,'MAX_TCGA_GENES':120,'MAX_TCGA_MUTATION_ROWS':250000, + 'SANGER_GDSC_AUTO_SEARCH':os.getenv('SANGER_GDSC_AUTO_SEARCH','1')=='1', + 'ROBUSTNESS_MIN_ARM':5,'RUN_L1O_ROBUSTNESS':True +} +FOURCFG={ + 'REFERENCE_RUN_ID':'FRESH_STANDALONE','MIN_GROUP_N':5, + 'MIN_PER_GROUP_IN_LINEAGE':2,'MIN_RESIDUAL_DF':8,'MAX_COND':1e9,'ALPHA':0.05 +} +O=Path(os.getenv('FINAL_COMUTATION_WORKSPACE','/kaggle/working/final_comutation_run'))/'results'/'Therapeutic' +ROOT=O +CACHE=O/'_LOCAL_SOURCE_CACHE' +OUT=O/'01_C1_And_Coverage' +STAGES={} +FOUR_OUT=O/'12_PRISM_Four_Group_Interaction' +SESSION=requests.Session() +SESSION.headers.update({'User-Agent':'FinalComutationTherapeutic/1.0 academic research'}) +STAGE_REPORT={};SOURCE_RECORDS=[];AUDIT=[] +LOG_FILE=O/'run_messages.txt' + +def initialize(workspace,raw_paths): + global O,ROOT,CACHE,OUT,STAGES,FOUR_OUT,LOG_FILE + STAGE_REPORT.clear(); SOURCE_RECORDS.clear(); AUDIT.clear() + CFG['PRISM_19Q4_CSV'] = os.getenv('FINAL_COMUTATION_PRISM_RAW_CSV','') + O=Path(workspace)/'results'/'Therapeutic';ROOT=O;CACHE=O/'_LOCAL_SOURCE_CACHE';OUT=O/'01_C1_And_Coverage' + FOUR_OUT=O/'12_PRISM_Four_Group_Interaction' + CFG['DEPMAP_24Q4_DIR']=str(Path(raw_paths['model']).parent) + EX['EXPRESSION_CSV']=str(raw_paths['expression']) if 'expression' in raw_paths else '' + STAGES={ + 'pathways':O/'02_Oncogenic_Pathway_Activity','indirect':O/'03_Indirect_Pathway_Evidence', + 'druggability':O/'04_Druggability_Prioritization','tcga':O/'05_TCGA_CoMutation_Prevalence', + 'prism':O/'06_PRISM_Drug_Response_Statistics','gdsc':O/'07_GDSC_Second_Assay', + 'independent':O/'08_Independent_Cohort_Check','integration':O/'09_Integrated_Results', + 'verification':O/'10_Verification_And_Figures','code':O/'11_Code_And_Methods' + } + for d in [O,CACHE,OUT,FOUR_OUT,*STAGES.values()]:d.mkdir(parents=True,exist_ok=True) + LOG_FILE=STAGES['verification']/'run_messages.txt' + return O + +def get_genotype_files(): + p=Path(CFG['DEPMAP_24Q4_DIR']) + names=['Model.csv','OmicsSomaticMutationsMatrixDamaging.csv','OmicsSomaticMutationsMatrixHotspot.csv'] + if not all((p/n).is_file() for n in names):raise FileNotFoundError('Fresh raw DepMap 24Q4 sources not present') + return {x:p/x for x in names} + +def get_prism_file(): + """Only the exact provider-verified PRISM 19Q4 v4 secondary assay file. + + A supplied local file is allowed as a bandwidth-saving *raw input*, but it + must match the same official file's size and MD5. Never accept an old result + table or an unverified hand-curated compound screen here. + """ + inv=figshare_files(9393293,4) + name='secondary-screen-dose-response-curve-parameters.csv' + if name not in inv:raise RuntimeError('Provider-verified PRISM 19Q4 v4 file not found') + info=inv[name] + if CFG['PRISM_19Q4_CSV']: + p=Path(CFG['PRISM_19Q4_CSV']).resolve() + if not p.is_file():raise FileNotFoundError(p) + expected_bytes=int(info.get('size') or 0) + expected_md5=str(info.get('computed_md5') or info.get('supplied_md5') or '').lower() + if not expected_bytes or not expected_md5: + raise RuntimeError('Official provider supplied no verifiable PRISM size/checksum') + h=hashlib.md5() + with p.open('rb') as f: + for chunk in iter(lambda:f.read(2**20),b''):h.update(chunk) + if p.stat().st_size!=expected_bytes or h.hexdigest()!=expected_md5: + raise RuntimeError('Local PRISM raw file is NOT identical to official pinned PRISM 19Q4 v4; refuse mixed/legacy input') + SOURCE_RECORDS.append({'source':'PRISM_19Q4_v4','provider_article':9393293,'provider_version':4, + 'provider_file_id':info.get('id'),'checksum':'MD5_MATCH','bytes':expected_bytes, + 'source_type':'OFFICIAL_RAW_LOCAL_BYTES_NOT_RESULT'}) + return p + p=official_file(info,CACHE/name) + SOURCE_RECORDS.append({'source':'PRISM_19Q4_v4','provider_article':9393293,'provider_version':4, + 'provider_file_id':info.get('id'),'checksum':'PROVIDER_VERIFIED', + 'source_type':'DOWNLOADED_OFFICIAL_RAW'}) + return p + +def record(key,**kwargs):SOURCE_RECORDS.append({'stage':key,**kwargs}) +def log(msg):print('[RawTherapy]',msg,flush=True) +def save_json(v,p): + p=Path(p);p.parent.mkdir(parents=True,exist_ok=True) + p.write_text(json.dumps(v,indent=2,default=str),encoding='utf-8') +def xlog(msg): + x=f'[{datetime.now(timezone.utc).isoformat()}] {msg}' + print(x,flush=True) + LOG_FILE.parent.mkdir(parents=True,exist_ok=True) + with LOG_FILE.open('a',encoding='utf-8') as f:f.write(x+'\n') +def mark(stage,status,**details): + STAGE_REPORT[stage]={'status':status,**details} + save_json(STAGE_REPORT,STAGES['verification']/'stage_status.json') + xlog(f'{stage}: {status} '+str(details)[:280]) +def errstage(stage,exc): + mark(stage,'NOT_COMPLETED',error=f'{type(exc).__name__}: {exc}'[:500]) + + + +def col(df, alternatives, required=True): + m={str(x).strip().lower():x for x in df.columns} + for x in alternatives: + if x.lower() in m:return m[x.lower()] + if required:raise ValueError(f'Missing column {alternatives}. Available: {list(df.columns)}') + return None + + +def stream_to(url, path, size=None, md5=None): + path=Path(path); path.parent.mkdir(parents=True,exist_ok=True) + def valid(): + if not path.is_file() or path.stat().st_size==0:return False + if size is not None and int(size)!=path.stat().st_size:return False + if md5: + h=hashlib.md5() + with open(path,'rb') as f: + for ch in iter(lambda:f.read(2**20),b''):h.update(ch) + return h.hexdigest()==md5.lower() + return True + if valid():return path + if path.exists():path.unlink() + if not CFG['AUTO_DOWNLOAD_MISSING']: + raise FileNotFoundError(f'Missing {path}. Download is disabled.') + tmp=Path(str(path)+'.partial') + for attempt in range(3): + try: + log(f'Downloading {path.name} (attempt {attempt+1})') + with SESSION.get(url,stream=True,timeout=(45,240)) as r: + r.raise_for_status() + if 'text/html' in r.headers.get('content-type','').lower(): + raise RuntimeError('HTML returned instead of file') + with open(tmp,'wb') as f: + for chunk in r.iter_content(2**20): + if chunk:f.write(chunk) + tmp.replace(path) + if not valid():raise RuntimeError('Size/MD5 source verification failed') + return path + except Exception: + tmp.unlink(missing_ok=True) + path.unlink(missing_ok=True) + if attempt==2:raise + time.sleep(2**attempt) + + +def figshare_files(article_id, version): + url=f'https://api.figshare.com/v2/articles/{article_id}/versions/{version}' + r=SESSION.get(url,timeout=90);r.raise_for_status();body=r.json() + if int(body.get('version',version))!=version:raise RuntimeError(f'Unexpected Figshare version at {url}') + names={x['name']:x for x in body.get('files',[])} + if not names:raise RuntimeError(f'No files returned by official provider: {url}') + return names + + +def official_file(info, dest): + return stream_to(info.get('download_url') or f'https://ndownloader.figshare.com/files/{info["id"]}', + dest,int(info['size']) if info.get('size') else None, + info.get('computed_md5') or info.get('supplied_md5')) + + +def canon_gene(s): + s=str(s).strip() + m=re.match(r'^(.*?)\s*\((\d+)\)\s*$',s) + if m:return 'ENTREZ:'+m.group(2) + if s.isdecimal():return 'ENTREZ:'+s + return 'SYMBOL:'+s.upper() + + +def mutation_matrix_selected(file, genes, id_index): + header=pd.read_csv(file,nrows=0).columns.tolist() + if len(header)<2:raise ValueError(f'Invalid mutation matrix: {file}') + idcol=header[0]; matched={canon_gene(h):h for h in header[1:] if canon_gene(h) in genes} + x=pd.read_csv(file,usecols=[idcol]+list(matched.values()),low_memory=False) + x=x.rename(columns={idcol:'ModelID',**{v:k for k,v in matched.items()}}) + x['ModelID']=x['ModelID'].astype(str).str.strip() + if x.ModelID.duplicated().any():raise RuntimeError(f'Duplicated model IDs in {file}') + x=x.set_index('ModelID').reindex(index=id_index, columns=sorted(genes)) + x=x.apply(pd.to_numeric,errors='coerce').astype('float32') + arr=x.to_numpy(dtype=float) + finite=arr[np.isfinite(arr)] + if len(finite) and (np.any(finite<0) or np.any(np.floor(finite)!=finite)): + raise ValueError(f'Unexpected mutation encoding in {file}') + return x, list(matched) + + +def get_genotypes(c1): + files=get_genotype_files() + models=pd.read_csv(files['Model.csv'],low_memory=False) + idc=col(models,['ModelID','DepMap_ID','DepMapID']) + lc=col(models,['OncotreeLineage','Lineage','lineage','primary_disease']) + models=models.rename(columns={idc:'ModelID',lc:'Lineage'}) + models.ModelID=models.ModelID.astype(str).str.strip() + if models.ModelID.duplicated().any():raise RuntimeError('Duplicate Model.csv IDs') + models=models.set_index('ModelID') + genes=set(c1.A.astype(str))|set(c1.B.astype(str)) + bad, bkeys=mutation_matrix_selected(files['OmicsSomaticMutationsMatrixDamaging.csv'],genes,models.index) + hot, hkeys=mutation_matrix_selected(files['OmicsSomaticMutationsMatrixHotspot.csv'],genes,models.index) + arrd=bad.to_numpy();arrh=hot.to_numpy() + x=np.where((np.isfinite(arrd)&(arrd>0))|(np.isfinite(arrh)&(arrh>0)),1, + np.where(np.isfinite(arrd)&np.isfinite(arrh),0,np.nan)).astype('float32') + geno=pd.DataFrame(x,index=models.index,columns=bad.columns) + models['Lineage']=models['Lineage'].fillna('Unclassified').astype(str) + record('genotype_coverage',n_models=int(len(models)),n_mutation_genes=int(len(genes)), + genes_present_damaging=int(len(bkeys)),genes_present_hotspot=int(len(hkeys)), + calls_undefined=int(geno.isna().sum().sum())) + return models,geno + + +def target_symbols(target): + if pd.isna(target):return set() + s=str(target).upper().strip() + if not s or s in ['NAN','UNKNOWN','NONE','N/A','NA','UNSPECIFIED']:return set() + return set(re.findall(r'(?1 screen/batch; reduce to ONE number per model-drug. + responses=df.groupby(['DrugID','ModelID'],as_index=False).agg( + ResponseAUC=('ResponseAUC','median'),n_screen_rows=('ResponseAUC','size')) + meta=df.groupby('DrugID',as_index=False).agg( + DrugName=('DrugName',lambda x:next((a for a in x if a),'')), + TargetGenes=('TargetGenes',lambda x:' | '.join(sorted({a for a in x if a}))), + MOA=('MOA',lambda x:next((a for a in x if a),'')), + ClinicalPhase=('ClinicalPhase',lambda x:next((a for a in x if a),''))) + meta['TargetSymbolSet']=meta.TargetGenes.map(target_symbols) + meta['NTargetsListed']=meta.TargetSymbolSet.map(len) + meta['Source']='PRISM_19Q4_secondary_AUC' + record('prism_19Q4',source=str(path),n_assay_rows=int(len(df)),n_drugs=int(meta.DrugID.nunique()), + n_models=int(responses.ModelID.nunique()),n_models_drugs=int(len(responses)), + n_drugs_with_explicit_target=int((meta.NTargetsListed>0).sum())) + return responses,meta + + +def get_extra_screens(): + # Optional harmonized rows for GDSC, CTRP, other releases; user must supply verified ACH IDs. + # Required columns: ModelID, DrugID, DrugName, TargetGenes, Response, Dataset. + if not CFG['EXTRA_SCREEN_CSV']:return pd.DataFrame(),pd.DataFrame() + p=Path(CFG['EXTRA_SCREEN_CSV']) + if not p.is_file():raise FileNotFoundError(f'EXTRA_SCREEN_CSV missing: {p}') + x=pd.read_csv(p,low_memory=False) + required=['ModelID','DrugID','DrugName','TargetGenes','Response','Dataset'] + missing=[c for c in required if c not in x] + if missing:raise ValueError(f'Canonical extra screen file missing columns: {missing}') + x['ModelID']=x.ModelID.astype(str).str.strip() + if not x.ModelID.str.fullmatch(r'ACH-\d{6}').all(): + raise RuntimeError('Extra screen must contain verified DepMap ACH model IDs; no name-based guessing') + x['Response']=pd.to_numeric(x.Response,errors='coerce') + x=x.dropna(subset=['Response']) + x['DrugID']=x.DrugID.astype(str) + x['Dataset']=x.Dataset.astype(str) + resp=x.groupby(['Dataset','DrugID','ModelID'],as_index=False).agg( + ResponseAUC=('Response','median'),n_screen_rows=('Response','size')) + meta=x.groupby(['Dataset','DrugID'],as_index=False).agg( + DrugName=('DrugName','first'),TargetGenes=('TargetGenes','first')) + meta['MOA']='';meta['ClinicalPhase']='';meta['Source']=meta.Dataset + meta['TargetSymbolSet']=meta.TargetGenes.map(target_symbols) + meta['NTargetsListed']=meta.TargetSymbolSet.map(len) + record('extra_screen',source=str(p),n_models_drugs=int(len(resp)),n_drugs=int(len(meta))) + return resp,meta + + +def index_response(responses, meta, dataset): + # Ensure drug-level response eligibility uses independent cell lines, not doses/replicates. + out={} + for drug_id,grp in responses.groupby('DrugID',sort=False): + out[str(drug_id)]=set(grp['ModelID'].astype(str)) + return out + + +def evaluate_feasibility(c1, models, geno, screens): + pairs=c1[['A','B','A_symbol','B_symbol']].drop_duplicates().copy() + result=[]; map_rows=[] + all_contexts=[] + coverage_index={dataset:index_response(responses,meta,dataset) for dataset,responses,meta in screens} + for a,b,asym,bsym in pairs.itertuples(index=False,name=None): + if a not in geno or b not in geno:continue + v=geno[[a,b]] + known=v.notna().all(axis=1) + aonly=set(v.index[known & v[a].eq(1) & v[b].eq(0)]) + both=set(v.index[known & v[a].eq(1) & v[b].eq(1)]) + all_contexts.append(dict(A=a,B=b,A_symbol=asym,B_symbol=bsym, + n10_all_models=len(aonly),n11_all_models=len(both))) + for target in sorted(c1.loc[(c1.A==a)&(c1.B==b),'gene_symbol'].astype(str).unique()): + s_target=target.strip().upper() + c1_rows=c1.loc[(c1.A==a)&(c1.B==b)&(c1.gene_symbol==target)] + q=float(pd.to_numeric(c1_rows.q_global_BY,errors='coerce').min()) + beta=float(pd.to_numeric(c1_rows.beta,errors='coerce').median()) + base={'A':a,'B':b,'A_symbol':asym,'B_symbol':bsym,'TargetGene':s_target, + 'C1_beta':beta,'C1_global_BY_q':q,'n10_all_genotyped':len(aonly), + 'n11_all_genotyped':len(both)} + for dataset,responses,meta in screens: + drug_sets=coverage_index[dataset] + hits=meta[meta.TargetSymbolSet.map(lambda ss:s_target in ss)].copy() + map_rows.append({**base,'Dataset':dataset,'n_target_matched_drugs':len(hits), + 'n_drugs_with_response_coverage':sum(len(drug_sets.get(str(d),set()))>0 for d in hits.DrugID)}) + for m in hits.itertuples(index=False): + models_this=drug_sets.get(str(m.DrugID),set()) & set(models.index) + arm10=sorted(aonly & models_this) + arm11=sorted(both & models_this) + l10=models.loc[arm10,'Lineage'].value_counts() + l11=models.loc[arm11,'Lineage'].value_counts() + shared=sorted(set(l10.index)&set(l11.index)) + supported=[lineage for lineage in shared if l10[lineage]>=CFG['MIN_PER_ARM_WITHIN_LINEAGE'] and l11[lineage]>=CFG['MIN_PER_ARM_WITHIN_LINEAGE']] + n10,n11=len(arm10),len(arm11) + adequate=(n10>=CFG['MIN_N_A_ONLY'] and n11>=CFG['MIN_N_A_B']) + if adequate and supported:category='FEASIBLE_FOR_FOLLOWUP_MODELING' + elif adequate:category='COUNTS_OK_BUT_NO_WITHIN_LINEAGE_OVERLAP' + elif n10+n11==0:category='NO_MATCHED_DRUG_RESPONSE' + else:category='UNDERPOWERED_OR_SPARSE_ARMS' + result.append({**base,'Dataset':dataset,'DrugID':m.DrugID, + 'DrugName':m.DrugName,'DrugTargets':m.TargetGenes, + 'DrugMOA':m.MOA,'NAnnotatedTargets':m.NTargetsListed, + 'MultitargetFlag':bool(m.NTargetsListed>CFG['MAX_TARGETS_PER_COMPOUND']), + 'n10_matched_drug_response':n10, + 'n11_matched_drug_response':n11, + 'n_lineages_in_both_arms':len(shared), + 'n_lineages_with_min_2_per_arm':len(supported), + 'supported_lineages':' | '.join(supported), + 'n_unique_model_ids':n10+n11, + 'feasibility_status':category, + 'independence':'DIFFERENT_ASSAY_SHARED_DEPMAP_GENOTYPE; NOT_INDEPENDENT_GENOTYPE_COHORT'}) + details=pd.DataFrame(result) + maps=pd.DataFrame(map_rows) + ctx=pd.DataFrame(all_contexts) + return details,maps,ctx + + +def sample_genotype_groups(c1,models,geno): + groups={} + for a,b in c1[['A','B']].drop_duplicates().itertuples(index=False,name=None): + if a not in geno or b not in geno:continue + v=geno[[a,b]] + keep=v.notna().all(axis=1) & v[a].eq(1) + groups[(a,b)]={ + 'A_ONLY':set(v.index[keep & v[b].eq(0)]), + 'A_B':set(v.index[keep & v[b].eq(1)]) + } + return groups + + +def original_other_mutation_burden(models,geno,c1): + """Screened-gene mutation burden, not exact per-genome somatic burden. + + For full-coverage 24Q4 matrices this computes OR(damaging,hotspot) across all + common columns. If resource-limited it returns no covariate, NEVER silently + substitutes number of the 42 nominated mutations. + """ + # NEVER include model-level genotype-derived values in publicly uploaded results. + path=CACHE/'mutation_burden_LOCAL_ONLY.csv' + if path.is_file(): + b=pd.read_csv(path,index_col=0).iloc[:,0] + return b.reindex(models.index) + source=get_genotype_files() + f1=source['OmicsSomaticMutationsMatrixDamaging.csv'] + f2=source['OmicsSomaticMutationsMatrixHotspot.csv'] + h1=pd.read_csv(f1,nrows=0).columns.to_list() + h2=pd.read_csv(f2,nrows=0).columns.to_list() + id1,id2=h1[0],h2[0] + # Original genotype construction uses columns common to both matrices. + s1={canon_gene(v):v for v in h1[1:]} + s2={canon_gene(v):v for v in h2[1:]} + keys=sorted(set(s1)&set(s2)) + if len(keys)<100: + raise RuntimeError('Not enough common genomic columns to compute burden') + x=pd.read_csv(f1,usecols=[id1]+[s1[k] for k in keys],low_memory=False) + y=pd.read_csv(f2,usecols=[id2]+[s2[k] for k in keys],low_memory=False) + x=x.set_index(id1).rename(columns={s1[k]:k for k in keys}) + y=y.set_index(id2).rename(columns={s2[k]:k for k in keys}) + if not x.index.is_unique or not y.index.is_unique:raise ValueError('Duplicate IDs in burden calculation') + shared=x.index.intersection(y.index) + if len(shared)<200:raise RuntimeError('Insufficient overlap between mutation matrices') + # Process 300 gene columns at a time to avoid keeping extra intermediate arrays. + result=np.zeros(len(shared),dtype=np.float64) + for j in range(0,len(keys),300): + kk=keys[j:j+300] + a=x.loc[shared,kk].to_numpy(dtype=float) + b=y.loc[shared,kk].to_numpy(dtype=float) + result+=(((np.isfinite(a)&(a>0))|(np.isfinite(b)&(b>0))).sum(axis=1)) + out=pd.Series(result,index=shared,name='qualifying_mutation_burden').reindex(models.index) + out.to_frame().to_csv(path) + SOURCE_RECORDS.append({'source':'mutation_burden','measurement':'all common damaging/hotspot gene columns', + 'n_candidate_mutation_genes':len(keys),'n_models_available':int(out.notna().sum())}) + return out + + +def active_model_design(df, include_lineage=True): + """Within A-mutated genotype with n>=5/arm and within-lineage overlap. + + Lineage fixed effects are formed ONLY for supported lineages; burden adjustment + is included only when externally computed complete burden is available. + """ + if df.empty or 'Bmut' not in df:return None,'NO_B_GROUP' + ct=pd.crosstab(df['Lineage'].fillna('Unclassified'),df.Bmut) + if 0 not in ct:ct[0]=0 + if 1 not in ct:ct[1]=0 + valid=ct.index[(ct[0]>=EX['MIN_WITHIN_LINEAGE']) & (ct[1]>=EX['MIN_WITHIN_LINEAGE'])] + d=df.loc[df.Lineage.isin(valid)].copy() + n0=int(d.Bmut.eq(0).sum());n1=int(d.Bmut.eq(1).sum()) + if min(n0,n1)1e-9:x['log_other_mut_burden']=cov + if include_lineage and d.Lineage.nunique()>1: + x=pd.concat([x,pd.get_dummies(d.Lineage,prefix='lin',drop_first=True,dtype=float)],axis=1) + m=x.to_numpy(dtype=float) + if len(d)-m.shape[1]1e9) and 'log_other_mut_burden' in x: + x=x.drop(columns=['log_other_mut_burden']) + m=x.to_numpy(dtype=float) + if np.linalg.matrix_rank(m)1e9:return None,'ILL_CONDITIONED_DESIGN' + return (d,x,n0,n1),None + + +def hc3_fit(df, outcome, offset=None): + if df.empty:return {'fit_status':'NO_RESPONSE'} + d=df.copy() + d['Y']=pd.to_numeric(d[outcome],errors='coerce') + d=d[np.isfinite(d.Y)].copy() + if d.index.duplicated().any():return {'fit_status':'DUPLICATE_MODEL_RESPONSES'} + design,why=active_model_design(d) + if design is None:return {'fit_status':why,'n_available':int(len(d))} + dd,x,n0,n1=design + y=dd.Y.to_numpy(dtype=float) + if np.nanstd(y)<1e-10:return {'fit_status':'ZERO_RESPONSE_VARIANCE','n10':n0,'n11':n1} + try: + fit=sm.OLS(y,x.to_numpy(dtype=float)).fit(cov_type='HC3',use_t=True) + b=float(fit.params[1]);se=float(fit.bse[1]);p=float(fit.pvalues[1]);ci=fit.conf_int(alpha=EX['ALPHA']) + lo,hi=map(float,ci[1]) + if not np.isfinite(p) or not np.isfinite(se) or se<=0: + return {'fit_status':'NONFINITE_STATISTICS','n10':n0,'n11':n1} + return {'fit_status':'TESTED','beta_AB_vs_Aonly':b,'hc3_se':se,'p':p, + 'ci_low':lo,'ci_high':hi,'n10':n0,'n11':n1, + 'n_total':n0+n1,'n_lineages':dd.Lineage.nunique(), + 'adjusted_for':'|'.join(x.columns.to_list()[2:]), + 'burden_not_adjusted_due_to_collinearity':bool('OtherBurden' in d and 'log_other_mut_burden' not in x.columns), + 'fit_df_resid':int(fit.df_resid), + 'mean10':float(dd.loc[dd.Bmut.eq(0),'Y'].mean()), + 'mean11':float(dd.loc[dd.Bmut.eq(1),'Y'].mean())} + except Exception as e: + return {'fit_status':'OLS_FAILED_'+type(e).__name__} + + +def adjust_global(df, dataset='dataset', pcol='p'): + df=df.copy() + df['q_global_BH']=np.nan;df['q_global_BY']=np.nan + if df.empty or pcol not in df:return df + if dataset not in df:df[dataset]='all' + for _,ids in df.groupby(dataset,dropna=False).groups.items(): + valid=[i for i in ids if pd.notna(df.at[i,pcol]) and 0<=df.at[i,pcol]<=1] + if valid: + p=df.loc[valid,pcol].astype(float).to_numpy() + df.loc[valid,'q_global_BH']=multipletests(p,method='fdr_bh')[1] + df.loc[valid,'q_global_BY']=multipletests(p,method='fdr_by')[1] + return df + + +def drug_run_stats(c1,models,geno,burden,details,responses,meta,dataset_name): + if details.empty:return pd.DataFrame() + lookup=responses[['DrugID','ModelID','ResponseAUC']].drop_duplicates(['DrugID','ModelID']) + rdict={str(d):g.set_index('ModelID')['ResponseAUC'] for d,g in lookup.groupby('DrugID')} + out=[];uniqs={x:row for x,row in c1.set_index(['A','B','gene_symbol']).iterrows()} if not c1.empty else {} + index_groups=sample_genotype_groups(c1,models,geno) + for rec in details.to_dict('records'): + if rec['Dataset']!=dataset_name:continue + a,b,drug=rec['A'],rec['B'],str(rec['DrugID']) + core={k:rec.get(k) for k in ['A','B','A_symbol','B_symbol','TargetGene','DrugID','DrugName','DrugTargets', + 'C1_beta','C1_global_BY_q','MultitargetFlag','NAnnotatedTargets']} + core['Dataset']=dataset_name + if drug not in rdict or (a,b) not in index_groups: + out.append({**core,'fit_status':'NO_RESPONSE'});continue + measures=rdict[drug] + grp=index_groups[(a,b)] + cands=sorted((grp['A_ONLY']|grp['A_B']) & set(measures.index) & set(models.index)) + if not cands: + out.append({**core,'fit_status':'NO_GENOTYPE_ASSAY_OVERLAP'});continue + dm=pd.DataFrame(index=pd.Index(cands,name='ModelID')) + dm['Bmut']=dm.index.isin(grp['A_B']).astype(int) + dm['Lineage']=models.loc[cands,'Lineage'].fillna('Unclassified').astype(str) + if burden is not None:dm['OtherBurden']=pd.to_numeric(burden.reindex(cands),errors='coerce')-1-dm.Bmut + dm['Response']=pd.to_numeric(measures.reindex(cands),errors='coerce') + fit=hc3_fit(dm,'Response') + core.update(fit) + core['n_screen_matched_models']=len(cands) + core['response_scale']='PRISM_VIABILITY_AUC_LOWER_MORE_SENSITIVE' if dataset_name.startswith('PRISM') else 'GDSC2_AUC_LOWER_MORE_SENSITIVE' + out.append(core) + result=adjust_global(pd.DataFrame(out),'Dataset','p') + if not result.empty: + for required in ['fit_status','beta_AB_vs_Aonly','C1_beta']: + if required not in result:result[required]=np.nan + result['direction_consistent_with_C1']=np.where(result.fit_status.eq('TESTED'), + ((pd.to_numeric(result.beta_AB_vs_Aonly,errors='coerce')<0)& + (pd.to_numeric(result.C1_beta,errors='coerce')<0))| + ((pd.to_numeric(result.beta_AB_vs_Aonly,errors='coerce')>0)& + (pd.to_numeric(result.C1_beta,errors='coerce')>0)),False) + result['support_status']=np.select([ + result.fit_status.ne('TESTED'), + result.q_global_BH.le(.05)&result.direction_consistent_with_C1, + result.q_global_BH.le(.05)&~result.direction_consistent_with_C1], + ['NOT_TESTED','FDR_SUPPORTED_DIRECTION_CONSISTENT','FDR_SIGNIFICANT_DISCORDANT'], + default='NOT_FDR_SUPPORTED') + return result + + +def run_prism(c1,models,geno,burden,details,responses,meta): + dat='PRISM_19Q4_secondary_AUC' + tested=drug_run_stats(c1,models,geno,burden,details,responses,meta,dat) + if tested.empty:mark('PRISM_statistics','NO_MATCHED_TESTS');return tested + tested.to_csv(STAGES['prism']/'PRISM_drug_response_HC3_BH_BY.csv',index=False) + summary={'n_input_rows':len(tested),'n_tested':int(tested.fit_status.eq('TESTED').sum()), + 'n_bh_significant':int(tested.q_global_BH.le(.05).sum()), + 'n_bh_direction_consistent':int(((tested.q_global_BH<=.05)&tested.direction_consistent_with_C1).sum()), + 'n_by_direction_consistent':int(((tested.q_global_BY<=.05)&tested.direction_consistent_with_C1).sum()), + 'n_distinct_supported_C1_associations':int(tested.loc[(tested.q_global_BH<=.05)&tested.direction_consistent_with_C1,['A','B','TargetGene']].drop_duplicates().shape[0]), + 'assay_independence':'SEPARATE_DRUG_VIABILITY_ASSAY_SAME_GENOTYPE_SOURCE; NOT_INDEPENDENT_COHORT', + 'mutation_call_note':'No reported qualifying mutation is NOT proven wild-type', + 'model':'OLS(B status + lineage fixed effects + other mutation burden where available), HC3 robust SE', + 'hypothesis_family':EX['HYPOTHESIS_FAMILY'], + 'q_computed_over':'All available PRISM TESTED gene-pair-drug hypotheses, including direction-discordant tests'} + save_json(summary,STAGES['prism']/'PRISM_inferential_summary.json') + mark('PRISM_statistics','ANALYZED',**{k:v for k,v in summary.items() if k.startswith('n_')}) + return tested + + +def run_prism_leave_one_lineage_out(c1, models, geno, burden, prism, responses): + """Post-selection sensitivity ONLY, not independent replication or new primary p-values. + For each estimable primary PRISM contrast, refit after excluding one lineage. + Suppress non-estimable refits and retain failure reasons. The same original p/q + values remain unchanged. No cell/model IDs are emitted to output files. + """ + report=STAGES['prism']/'PRISM_Leave_One_Lineage_Out_Robustness.csv' + rows=[] + if prism.empty or not EX['RUN_L1O_ROBUSTNESS']: + pd.DataFrame(columns=['A','B','TargetGene','DrugID','Dataset','n_refits_tested','n_refits_attempted', + 'fraction_direction_stable','max_abs_change_in_beta','robustness_status']).to_csv(report,index=False) + mark('PRISM_lineage_robustness','SKIPPED' if not EX['RUN_L1O_ROBUSTNESS'] else 'NO_TESTABLE_CONTRASTS') + return pd.DataFrame() + samplegroups=sample_genotype_groups(c1,models,geno) + rdict={str(k):g.set_index('ModelID')['ResponseAUC'] for k,g in responses.groupby('DrugID')} + for row in prism.loc[prism.fit_status.eq('TESTED')].itertuples(index=False): + k=(row.A,row.B) + grp=samplegroups.get(k) + vals=rdict.get(str(row.DrugID)) + if not grp or vals is None:continue + ids=sorted((grp['A_ONLY']|grp['A_B'])&set(vals.index)&set(models.index)) + if not ids:continue + d=pd.DataFrame(index=pd.Index(ids,name='ModelID')) + d['Bmut']=d.index.isin(grp['A_B']).astype(int) + d['Lineage']=models.loc[ids,'Lineage'].fillna('Unclassified').astype(str) + d['Response']=pd.to_numeric(vals.reindex(ids),errors='coerce') + if burden is not None: + d['OtherBurden']=pd.to_numeric(burden.reindex(ids),errors='coerce')-1-d.Bmut + lineages=sorted(d.Lineage.unique()) + surviving=[]; attempts=0; omitted=[] + for lineage in lineages: + attempts+=1 + z=hc3_fit(d.loc[d.Lineage.ne(lineage)],'Response') + if z.get('fit_status')=='TESTED':surviving.append(float(z['beta_AB_vs_Aonly'])) + else:omitted.append(z.get('fit_status','UNKNOWN')) + orig=float(row.beta_AB_vs_Aonly) + frac=float(np.mean(np.sign(surviving)==np.sign(orig))) if surviving else np.nan + maxdiff=float(np.max(np.abs(np.asarray(surviving)-orig))) if surviving else np.nan + rows.append({'A':row.A,'B':row.B,'TargetGene':row.TargetGene,'DrugID':row.DrugID, + 'Dataset':row.Dataset,'original_beta':orig,'n_refits_attempted':attempts, + 'n_refits_tested':len(surviving),'fraction_direction_stable':frac, + 'max_abs_change_in_beta':maxdiff, + 'robustness_status':'COMPUTED' if surviving else 'NONESTIMABLE_DUE_TO_SAMPLE_OR_DESIGN', + 'nonestimable_reason_categories':' | '.join(sorted(set(omitted)))}) + table=pd.DataFrame(rows) + table.to_csv(report,index=False) + n_valid=int(table.robustness_status.eq('COMPUTED').sum()) if len(table) else 0 + n_allstable=int((table.fraction_direction_stable.eq(1)&table.robustness_status.eq('COMPUTED')).sum()) if len(table) else 0 + mark('PRISM_lineage_robustness','ANALYZED',n_contrasts_with_estimable_refits=n_valid, + n_all_estimated_refits_same_direction=n_allstable) + return table + + +def parse_gmt(path): + sets={} + for line in Path(path).read_text(encoding='utf-8').splitlines(): + a=line.strip().split('\t') + if len(a)>=3: + sym={str(g).strip().upper() for g in a[2:] if g.strip()} + if EX['MIN_PATHWAY_GENES']<=len(sym)<=EX['MAX_PATHWAY_GENES']: + sets[a[0]]=sym + return sets + + +def load_oncogenic_sets(): + if EX['PATHWAY_GMT']: + p=Path(EX['PATHWAY_GMT']);return parse_gmt(p),{'provider':'user_supplied_GMT','path':str(p)} + # Enrichr dynamically exposes gene sets; no need for MSigDB login/credentials. + url='https://maayanlab.cloud/Enrichr/geneSetLibrary?mode=text&libraryName=MSigDB_Oncogenic_Signatures' + try: + rr=SESSION.get(url,timeout=65);rr.raise_for_status() + p=CACHE/'MSigDB_Oncogenic_Signatures_Enrichr.gmt' + p.parent.mkdir(parents=True,exist_ok=True) + p.write_text(rr.text,encoding='utf-8') + ss=parse_gmt(p) + if len(ss)<10:raise ValueError(f'Only {len(ss)} usable oncogenic signatures') + return ss,{'provider':'Enrichr_MSigDB_Oncogenic_Signatures','url':url,'n_loaded':len(ss)} + except Exception as e: + return {},{'provider':'Enrichr_MSigDB_Oncogenic_Signatures','status':'UNAVAILABLE','error':str(e)[:280]} + + +def load_expression(models,sets): + path=EX['EXPRESSION_CSV'] + if path: + p=Path(path) + if not p.is_file():raise FileNotFoundError('DEPMAP_EXPRESSION_CSV not found') + else: + choices=[Path(CFG['DEPMAP_24Q4_DIR'])/'OmicsExpressionProteinCodingGenesTPMLogp1.csv'] + existing=next((x for x in choices if x.is_file()),None) + if existing is not None:p=existing + else: + inv=figshare_files(27993248,1) + name='OmicsExpressionProteinCodingGenesTPMLogp1.csv' + if name not in inv:raise FileNotFoundError('Official 24Q4 expression matrix unavailable') + p=official_file(inv[name],CACHE/'DepMap_24Q4_Public_v1'/name) + header=pd.read_csv(p,nrows=0).columns.to_list() + interest=set().union(*sets.values()) if sets else set() + def symbol(c): + s=str(c).strip() + if ' (' in s:return s.rsplit(' (',1)[0].upper().strip() + return s.upper() + selected={c:symbol(c) for c in header[1:] if symbol(c) in interest} + if len(selected)<50:raise RuntimeError('Fewer than 50 oncogenic signature genes covered by expression') + expr=pd.read_csv(p,usecols=[header[0]]+list(selected),low_memory=False) + expr=expr.rename(columns={header[0]:'ModelID',**selected}).set_index('ModelID') + expr.index=expr.index.astype(str).str.strip() + if expr.index.duplicated().any():raise RuntimeError('Duplicate expression ModelID') + # Some releases carry duplicate names for separate Ensembl/Entrez IDs. + expr=expr.T.groupby(level=0).mean().T + expr=expr.apply(pd.to_numeric,errors='coerce').reindex(models.index) + expr=expr.loc[:,expr.notna().sum()>=10] + return expr,{'file':str(p),'n_expression_models':int(expr.notna().any(axis=1).sum()), + 'n_expression_gene_symbols':int(expr.shape[1])} + + +def compute_pathway_activity(c1,models,geno,burden): + sets,source=load_oncogenic_sets() + save_json(source,STAGES['pathways']/'gene_set_provenance.json') + if not sets: + mark('pathways','DATA_NOT_AVAILABLE',reason='No usable external oncogenic signature sets');return pd.DataFrame(),{} + expr,ex_info=load_expression(models,sets) + # Gene standardization among measured models, not GSVA/ssGSEA. + mu=expr.mean(axis=0,skipna=True) + sd=expr.std(axis=0,skipna=True,ddof=1).replace(0,np.nan) + z=(expr-mu)/sd + z=z.replace([np.inf,-np.inf],np.nan) + usable={s:sorted(gg&set(z.columns)) for s,gg in sets.items()} + usable={s:g for s,g in usable.items() if len(g)>=EX['MIN_MEASURED_PATHWAY_GENES']} + if not usable:mark('pathways','NO_MEASURABLE_SIGNATURES');return pd.DataFrame(),{} + pathways=list(usable)[:EX['MAX_PATHWAYS']] + score_series={} + for p in pathways: + subset=z[usable[p]] + score_series[p]=subset.mean(axis=1,skipna=True).where( + subset.notna().sum(axis=1)>=max(5,int(len(usable[p])*.5))) + scores=pd.DataFrame(score_series,index=z.index) + # No per-cell expression or scores uploaded; only aggregate effects. + grp=sample_genotype_groups(c1,models,geno) + out=[] + for (a,b),arms in grp.items(): + ids=sorted((arms['A_ONLY']|arms['A_B']) & set(scores.index)) + if len(ids)<10:continue + dd=pd.DataFrame(index=pd.Index(ids,name='ModelID')) + dd['Bmut']=dd.index.isin(arms['A_B']).astype(int) + dd['Lineage']=models.loc[ids,'Lineage'].fillna('Unclassified').astype(str) + if burden is not None: + dd['OtherBurden']=pd.to_numeric(burden.reindex(ids),errors='coerce')-1-dd.Bmut + for sig in pathways: + dd['PathwayScore']=scores.loc[ids,sig] + fit=hc3_fit(dd,'PathwayScore') + if fit.get('fit_status')!='TESTED':continue + sym=c1.loc[(c1.A==a)&(c1.B==b),['A_symbol','B_symbol']].iloc[0] + out.append({'A':a,'B':b,'A_symbol':sym.A_symbol,'B_symbol':sym.B_symbol, + 'Pathway':sig,'n_genes_measured':len(usable[sig]), + 'score_definition':'mean z-scored log1p TPM across measured pathway genes', + 'dataset':'DepMap_24Q4_expression',**fit}) + tab=adjust_global(pd.DataFrame(out),'dataset','p') + tab.to_csv(STAGES['pathways']/'Oncogenic_Pathway_A_B_Comparison_HC3.csv',index=False) + save_json({**ex_info,'pathway_set':source,'n_pathways_tested':len(pathways), + 'n_hypotheses_tested':len(tab),'n_BH_05':int(tab.q_global_BH.le(.05).sum()) if len(tab) else 0, + 'n_BY_05':int(tab.q_global_BY.le(.05).sum()) if len(tab) else 0, + 'interpretation':'Associations of pathway expression activity, not verified pathway rewiring or mediation'}, + STAGES['pathways']/'Pathway_Summary.json') + mark('pathways','ANALYZED',n_tests=len(tab),n_bh_05=int(tab.q_global_BH.le(.05).sum()) if len(tab) else 0) + return tab,usable + + +def derive_indirect(c1,pathways,members): + # Descriptive coherence ONLY; indirect mediation not identifiable with this test. + if pathways.empty: + mark('indirect','DATA_NOT_AVAILABLE',reason='Pathway stage has no testable results') + return pd.DataFrame() + pos=pathways[pathways.q_global_BH.le(.10)].copy() + annotated=[] + for c in c1.itertuples(index=False): + hits=pos[(pos.A==c.A)&(pos.B==c.B)] + for row in hits.itertuples(index=False): + target_in=row.Pathway in members and str(c.gene_symbol).upper() in members[row.Pathway] + annotated.append({'A_symbol':c.A_symbol,'B_symbol':c.B_symbol,'TargetGene':c.gene_symbol, + 'C1_beta':c.beta,'C1_q_global_BY':c.q_global_BY,'Pathway':row.Pathway, + 'Pathway_beta':row.beta_AB_vs_Aonly,'Pathway_q_global_BH':row.q_global_BH, + 'Target_is_signature_member':bool(target_in), + 'Claim':'EXPLORATORY_PATHWAY_COHERENCE_ONLY_NO_TEST_OF_CAUSAL_MEDIATION'}) + tab=pd.DataFrame(annotated) + tab.to_csv(STAGES['indirect']/'Exploratory_Indirect_Pathway_Concordance.csv',index=False) + mark('indirect','ANNOTATION_ONLY_NOT_MEDIATION',n_links=len(tab)) + return tab + + +def annotate_druggability(c1,meta,details,prism_results): + tt=meta.copy() + tt['TargetSymbolSet']=tt.TargetGenes.map(target_symbols) + rows=[] + for r in c1.itertuples(index=False): + hits=tt[tt.TargetSymbolSet.map(lambda s:str(r.gene_symbol).upper() in s)].copy() + subset=details[(details.A==r.A)&(details.B==r.B)&(details.TargetGene==str(r.gene_symbol).upper())] if not details.empty else pd.DataFrame() + f=subset[subset.feasibility_status.eq('FEASIBLE_FOR_FOLLOWUP_MODELING')] if not subset.empty else pd.DataFrame() + good=0 + if not prism_results.empty: + z=prism_results[(prism_results.A==r.A)&(prism_results.B==r.B)& + (prism_results.TargetGene==str(r.gene_symbol).upper())] + good=int(z.support_status.eq('FDR_SUPPORTED_DIRECTION_CONSISTENT').sum()) if 'support_status' in z else 0 + # target annotation denotes a drug mapping, not a validated direct inhibitor or FDA-approved indication. + selectivity=sorted(int(x) for x in hits.NTargetsListed.dropna() if int(x)>0) + rows.append({'A':r.A,'B':r.B,'A_symbol':r.A_symbol,'B_symbol':r.B_symbol, + 'gene':r.gene,'TargetGene':r.gene_symbol,'C1_beta':r.beta,'C1_global_BY_q':r.q_global_BY, + 'n_PRISM_compounds_target_annotated':int(len(hits)), + 'n_PRISM_compounds_with_feasible_response':int(len(f)), + 'n_direction_consistent_PRISM_fdr_supported':good, + 'smallest_annotated_target_count':min(selectivity) if selectivity else np.nan, + 'n_drugs_with_clinical_phase_annotations':int(hits.ClinicalPhase.astype(str).str.strip().ne('').sum()) if len(hits) else 0, + 'example_compounds':' | '.join(hits.DrugName.astype(str).unique()[:5]), + 'druggability_evidence':'PUBLIC_DRUG_TARGET_ANNOTATION_NOT_CONFIRMED_ON_TARGET', + 'therapeutic_claim':'COMPUTATIONAL_PRIORITIZATION_ONLY'}) + result=pd.DataFrame(rows) + result.to_csv(STAGES['druggability']/'C1_Compound_Target_Clinical_Phase_Annotations.csv',index=False) + mark('druggability','ANNOTATED',n_C1=len(result),n_targetable=int((result.n_PRISM_compounds_target_annotated>0).sum())) + return result + + +def cbio_json(url,params=None,body=None): + rr=SESSION.post(url,json=body,timeout=EX['TCGA_REQUEST_TIMEOUT']) if body is not None else SESSION.get(url,params=params,timeout=EX['TCGA_REQUEST_TIMEOUT']) + rr.raise_for_status() + return rr.json() + + +def tcga_sample_lists(study): + base=f'https://www.cbioportal.org/api/studies/{study}' + lists=cbio_json(base+'/sample-lists',params={'projection':'DETAILED'}) + if not isinstance(lists,list):raise RuntimeError('sample-lists is not a list') + eligible=[x for x in lists if 'sequenced' in str(x.get('sampleListId','')).lower()] + if not eligible: + eligible=[x for x in lists if 'all' in str(x.get('sampleListId','')).lower()] + if not eligible:raise RuntimeError('No enumerated samples in study') + sample_list=eligible[0];list_id=sample_list['sampleListId'] + sample_ids=sample_list.get('sampleIds') + if not sample_ids: + full=cbio_json('https://www.cbioportal.org/api/sample-lists/'+list_id) + sample_ids=full.get('sampleIds',[]) + if not sample_ids:raise RuntimeError('Study sample list missing IDs') + return list_id,list(map(str,sample_ids)),('sequenced' in str(list_id).lower()) + + +def run_tcga(c1): + if not EX['DO_PATIENT_TCGA']: + mark('tcga','DISABLED_BY_CONFIG');return pd.DataFrame() + symbols=sorted(set(c1.A_symbol.astype(str))|set(c1.B_symbol.astype(str))) + ent=set([int(x.split(':')[1]) for x in list(c1.A)+list(c1.B) if str(x).startswith('ENTREZ:')]) + if len(ent)>EX['MAX_TCGA_GENES']: + mark('tcga','TOO_MANY_MUTATION_GENES');return pd.DataFrame() + rows=[];per_study=[] + for study in EX['TCGA_STUDIES']: + try: + lsid,sids,sequenced=tcga_sample_lists(study) + # This is a patient-level denominator from TCGA patient barcodes. + # IMPORTANT: any reported alteration, not exact DepMap damaging/hotspot definition. + profiles=cbio_json(f'https://www.cbioportal.org/api/studies/{study}/molecular-profiles') + mut_profiles=[p for p in profiles if 'mutation' in str(p.get('molecularAlterationType','')).lower()] + if not mut_profiles: + mut_profiles=[p for p in profiles if 'mutation' in str(p.get('molecularProfileId','')).lower()] + if not mut_profiles:raise RuntimeError('No mutation molecular profile') + prof=mut_profiles[0]['molecularProfileId'] + endpoint=f'https://www.cbioportal.org/api/molecular-profiles/{prof}/mutations/fetch' + mutations=cbio_json(endpoint,body={'sampleListId':lsid,'entrezGeneIds':sorted(ent)}) + if not isinstance(mutations,list):raise RuntimeError('Mutation fetch did not return a list') + if len(mutations)>EX['MAX_TCGA_MUTATION_ROWS']:raise RuntimeError('Mutation response too large') + # Reported mutation = non-silent if annotation available; do not assume + # unreported mutation is confirmed WT or whole-panel gene callable. + good={} + silent={'silent','intron','intron_variant','rna','3_prime_utr_variant','5_prime_utr_variant','ig_region','intergenic'} + sid_set=set(sids) + for m in mutations: + sample=str(m.get('sampleId','')) + if sample not in sid_set:continue + gene=str(m.get('entrezGeneId',m.get('gene',{}).get('entrezGeneId',''))) + var=str(m.get('variantClassification',m.get('mutationType',''))).lower().replace(' ','_') + if var in silent:continue + if not gene.isdigit():continue + patient=sample[:12] if sample.startswith('TCGA-') else sample + good.setdefault(int(gene),set()).add(patient) + patients={s[:12] if s.startswith('TCGA-') else s for s in sids} + n=len(patients) + if n<=0:raise RuntimeError('No patient IDs') + for r in c1[['A','B','A_symbol','B_symbol']].drop_duplicates().itertuples(index=False): + aa=int(str(r.A).split(':')[-1]);bb=int(str(r.B).split(':')[-1]);ab=good.get(aa,set())&good.get(bb,set()) + rows.append({'Study':study,'A':r.A,'B':r.B,'A_symbol':r.A_symbol,'B_symbol':r.B_symbol, + 'n_mutation_profile_patients':n,'n_A_any_reported_nonsilent':len(good.get(aa,set())), + 'n_B_any_reported_nonsilent':len(good.get(bb,set())), + 'n_AB_any_reported_nonsilent':len(ab),'AB_fraction':len(ab)/n, + 'sample_list':lsid,'sample_list_is_sequenced':bool(sequenced), + 'TCGA_mutation_definition':'Any reported nonsilent mutation; different from DepMap damaging/hotspot', + 'interpretation':'Descriptive prevalence in the selected TCGA study; not drug-response evidence'}) + per_study.append({'study':study,'status':'COMPUTED','sample_list':lsid,'n_samples':len(sids),'n_patients':n}) + xlog(f'TCGA {study}: {n} patients; fetched {len(mutations)} mutations') + except Exception as e: + per_study.append({'study':study,'status':'NOT_COMPUTED','error':str(e)[:350]}) + xlog(f'TCGA {study}: unavailable ({str(e)[:130]})') + tab=pd.DataFrame(rows) + tab.to_csv(STAGES['tcga']/'Selected_TCGA_Study_Patient_Mutation_Cooccurrence.csv',index=False) + save_json({'studies':per_study,'not_pan_cancer_prevalence':True, + 'no_normal_coverage_implied':True,'no_drug_efficacy_inferred':True},STAGES['tcga']/'TCGA_provenance_and_coverage.json') + mark('tcga','PARTIAL_OR_COMPLETE' if len(tab) else 'DATA_NOT_AVAILABLE',n_studies_computed=sum(x['status']=='COMPUTED' for x in per_study),n_rows=len(tab)) + return tab + + +def discover_gdsc2_file(): + if EX['GDSC2_CSV']: + p=Path(EX['GDSC2_CSV']);return p if p.exists() else None + pats=['/kaggle/input/**/*GDSC2*.*','/kaggle/input/**/*gdsc2*.*'] + import glob + for pat in pats: + for name in sorted(glob.glob(pat,recursive=True)): + p=Path(name) + if (p.suffix.lower() in ('.csv','.tsv','.xlsx') and p.stat().st_size>100000 + and any(k in p.name.lower() for k in ('fitted','dose_response')) + and 'raw' not in p.name.lower()): + return p + # No unsupported guessed direct URL. Search Sanger public landing page for an + # explicit GDSC2 fitted-dose-response link; if absent record data unavailable. + if EX['SANGER_GDSC_AUTO_SEARCH']: + try: + from bs4 import BeautifulSoup + url='https://cellmodelpassports.sanger.ac.uk/downloads/gdsc' + res=SESSION.get(url,timeout=35);res.raise_for_status() + soup=BeautifulSoup(res.text,'html.parser') + for link in soup.find_all('a',href=True): + title=link.get_text(' ',strip=True).lower() + href=link['href'] + if ('gdsc2' in title or 'gdsc2' in href.lower()) and ('.csv' in href or '.xlsx' in href or '/downloads/' in href): + from urllib.parse import urljoin + url2=urljoin(url,href) + suffix='.xlsx' if '.xlsx' in url2.lower() else '.csv' + target=CACHE/('GDSC2_fitted_public'+suffix) + stream_to(url2,target) + SOURCE_RECORDS.append({'source':'GDSC2','download_url':url2}) + return target + except Exception as e: + SOURCE_RECORDS.append({'source':'GDSC2','status':'AUTO_DISCOVERY_FAILED','reason':str(e)[:200]}) + # Explicit filename/release reported by Sanger, not an inferred scraping result. + # The fixed provider URL is attempted only after local/uploaded verified candidates. + # Never accept an HTML error response or an invalid XLSX/ZIP signature. + if EX['SANGER_GDSC_AUTO_SEARCH']: + fixed_url='https://cog.sanger.ac.uk/cancerrxgene/GDSC_data_8.5/GDSC2_fitted_dose_response_27Oct23.xlsx' + path=CACHE/'GDSC2_fitted_dose_response_27Oct23.xlsx' + try: + if path.exists(): + with open(path,'rb') as f: + if f.read(4) != b'PK\x03\x04': path.unlink() + if not path.exists(): + stream_to(fixed_url,path) + with open(path,'rb') as f: + if f.read(4)!=b'PK\x03\x04': + raise ValueError('Official GDSC2 file failed XLSX ZIP signature check') + SOURCE_RECORDS.append({'source':'GDSC2','download_url':fixed_url, + 'status':'OFFICIAL_FIXED_VERSION_SOURCE'}) + return path + except Exception as exc: + path.unlink(missing_ok=True) + SOURCE_RECORDS.append({'source':'GDSC2','status':'OFFICIAL_DIRECT_DOWNLOAD_FAILED', + 'url':fixed_url,'reason':str(exc)[:200]}) + return None + + +def clean_gdsc2(path,models): + p=Path(path) + if p.suffix.lower()=='.xlsx':df=pd.read_excel(p) + elif p.suffix.lower()=='.tsv':df=pd.read_csv(p,sep='\t',low_memory=False) + else:df=pd.read_csv(p,low_memory=False) + def get(fams,required=True):return col(df,fams,required=required) + sanger=get(['SANGER_MODEL_ID','sanger_model_id','MODEL_ID','model_id']) + d_id=get(['DRUG_ID','drug_id']) + d_name=get(['DRUG_NAME','drug_name']) + tgene=get(['PUTATIVE_TARGET','putative_target','target']) + auc=get(['AUC','auc']) + # Match using official SangerModelID -> DepMap ModelID, not cell names. + mid=col(models.reset_index(),['SangerModelID','Sanger_Model_ID','sanger_model_id','SangerModelId'],required=False) + if mid is None:raise RuntimeError('Model.csv lacks SangerModelID; no verified Sanger-to-DepMap mapping') + mt=models.reset_index()[['ModelID',mid]].copy() + mt[mid]=mt[mid].astype(str).str.strip() + if mt[mid].duplicated().any(): + mt=mt[mt[mid].ne('nan')&mt[mid].ne('')].copy() + if mt[mid].duplicated().any():raise RuntimeError('Sanger ID maps to multiple DepMap models') + df=df.rename(columns={sanger:'SangerModelID',d_id:'DrugID',d_name:'DrugName',tgene:'TargetGenes',auc:'ResponseAUC'}) + df['SangerModelID']=df.SangerModelID.astype(str).str.strip() + mt=mt.rename(columns={mid:'SangerModelID'}) + df=df.merge(mt[['ModelID','SangerModelID']],on='SangerModelID',how='inner',validate='many_to_one') + df['ResponseAUC']=pd.to_numeric(df.ResponseAUC,errors='coerce') + df=df[np.isfinite(df.ResponseAUC)].copy() + df['DrugID']=df.DrugID.astype(str).str.strip() + df['TargetGenes']=df.TargetGenes.fillna('').astype(str) + df['DrugName']=df.DrugName.fillna('').astype(str) + reps=df.groupby(['DrugID','ModelID'],as_index=False).agg(ResponseAUC=('ResponseAUC','median')) + meta=df.groupby('DrugID',as_index=False).agg(DrugName=('DrugName','first'),TargetGenes=('TargetGenes','first')) + meta['TargetSymbolSet']=meta.TargetGenes.map(target_symbols) + meta['NTargetsListed']=meta.TargetSymbolSet.map(len) + meta['MOA']='';meta['ClinicalPhase']='' + return reps,meta + + +def gdsc_coverage(c1,models,geno,responses,meta): + groups=sample_genotype_groups(c1,models,geno) + drugset={d:set(g.ModelID) for d,g in responses.groupby('DrugID')} + rows=[] + for r in c1.itertuples(index=False): + arms=groups.get((r.A,r.B)) + if not arms:continue + matches=meta[meta.TargetSymbolSet.map(lambda s:r.gene_symbol.upper() in s)] + for d in matches.itertuples(index=False): + avail=drugset.get(d.DrugID,set()) + arm10=sorted(avail&arms['A_ONLY']);arm11=sorted(avail&arms['A_B']) + l10=models.loc[arm10,'Lineage'].value_counts() + l11=models.loc[arm11,'Lineage'].value_counts() + good=set(l10.index)&set(l11.index) + sufficient=any(l10[x]>=2 and l11[x]>=2 for x in good) + feasible=min(len(arm10),len(arm11))>=5 and sufficient + rows.append({'A':r.A,'B':r.B,'A_symbol':r.A_symbol,'B_symbol':r.B_symbol, + 'TargetGene':r.gene_symbol,'DrugID':d.DrugID,'DrugName':d.DrugName, + 'DrugTargets':d.TargetGenes,'C1_beta':r.beta,'C1_global_BY_q':r.q_global_BY, + 'NAnnotatedTargets':d.NTargetsListed,'MultitargetFlag':d.NTargetsListed>6, + 'Dataset':'GDSC2_SANGER_MAPPED_TO_DEPMAP','n10_matched_drug_response':len(arm10), + 'n11_matched_drug_response':len(arm11), + 'feasibility_status':'FEASIBLE_FOR_FOLLOWUP_MODELING' if feasible else 'UNDERPOWERED_OR_SPARSE_ARMS'}) + return pd.DataFrame(rows) + + +def run_gdsc2(c1,models,geno,burden,prism): + path=discover_gdsc2_file() + if path is None: + mark('GDSC2','DATA_NOT_AVAILABLE',reason='No provider-verified GDSC2 fitted AUC CSV/XLSX and model crosswalk');return pd.DataFrame() + resp,meta=clean_gdsc2(path,models) + cover=gdsc_coverage(c1,models,geno,resp,meta) + if cover.empty: + mark('GDSC2','NO_C1_TARGET_COMPOUND_MATCHES');return pd.DataFrame() + cover.to_csv(STAGES['gdsc']/'GDSC2_drug_target_and_group_coverage.csv',index=False) + res=drug_run_stats(c1,models,geno,burden,cover,resp,meta,'GDSC2_SANGER_MAPPED_TO_DEPMAP') + res.to_csv(STAGES['gdsc']/'GDSC2_assay_HC3_BH_BY.csv',index=False) + # Match same compound by exact normalized name; not equivalent mechanism/drug class. + overlaps=[] + if not prism.empty and not res.empty: + pp=prism[prism.fit_status.eq('TESTED')].copy();gg=res[res.fit_status.eq('TESTED')].copy() + pp['drug_key']=pp.DrugName.astype(str).str.upper().str.replace(r'[^A-Z0-9]','',regex=True) + gg['drug_key']=gg.DrugName.astype(str).str.upper().str.replace(r'[^A-Z0-9]','',regex=True) + overlaps=pp.merge(gg,on=['A','B','TargetGene','drug_key'],suffixes=('_PRISM','_GDSC')) + overlaps['same_direction']=np.sign(overlaps.beta_AB_vs_Aonly_PRISM)==np.sign(overlaps.beta_AB_vs_Aonly_GDSC) + overlaps.to_csv(STAGES['gdsc']/'PRISM_GDSC_exact_drug_cross_assay_concordance.csv',index=False) + save_json({'GDSC2_source':str(path),'n_GDSC2_target_drug_tests':len(res), + 'n_GDSC2_estimable':int(res.fit_status.eq('TESTED').sum()) if not res.empty else 0, + 'n_cross_assay_exact_drug_analyses':len(overlaps), + 'independence':'SEPARATE_ASSAY_NOT_VERIFIED_INDEPENDENT_BIOLOGICAL_COHORT', + 'genotypes':'REUSED_DEPMAP_24Q4','matching':'SangerModelID exact; never name-only'}, + STAGES['gdsc']/'GDSC2_assay_status.json') + mark('GDSC2','ASSAY_ANALYZED_NOT_INDEPENDENT_COHORT',n_tests=len(res),n_exact_drug_pairs=len(overlaps)) + return res + + +def run_independent_cohort(c1,models,prism): + """Strict optional external data. No unverified identity => no independence claim. + Canonical columns: Dataset, CanonicalModelID, A_symbol, B_symbol, TargetGene, + DrugName, A_mut, B_mut, ResponseAUC, Lineage, ProviderEvidence, + GenotypeSource. Groups are defined from independently measured A/B variants. + External rows must be nonoverlapping canonical cell identities against DepMap. + """ + p=EX['EXTERNAL_VERIFIED_SCREEN_CSV'] + if not p: + mark('independent_cohort','NOT_AVAILABLE',reason='No externally genotyped, verifiably non-overlapping cohort file');return pd.DataFrame() + p=Path(p) + if not p.is_file():mark('independent_cohort','INPUT_FILE_MISSING');return pd.DataFrame() + ext=pd.read_csv(p,low_memory=False) + required=['Dataset','CanonicalModelID','A_symbol','B_symbol','TargetGene','DrugName', + 'A_mut','B_mut','ResponseAUC','Lineage','ProviderEvidence','GenotypeSource'] + bad=[c for c in required if c not in ext] + if bad:raise ValueError('External cohort missing strict provenance and genotype columns: '+str(bad)) + ext['CanonicalModelID']=ext.CanonicalModelID.astype(str).str.strip() + ext['Dataset']=ext.Dataset.astype(str).str.strip() + # A new namespace is not proof of new biological samples. This audit checks for + # known original IDs; genuine independence still requires human provenance review. + overlapped=set(ext.CanonicalModelID)&set(models.index) + if overlapped: + ext=ext.loc[~ext.CanonicalModelID.isin(overlapped)].copy() + if ext.empty: + mark('independent_cohort','NO_NONOVERLAPPING_MODELS');return pd.DataFrame() + ext[['A_mut','B_mut']]=ext[['A_mut','B_mut']].apply(pd.to_numeric,errors='coerce') + ext['ResponseAUC']=pd.to_numeric(ext.ResponseAUC,errors='coerce') + ext=ext[ext.A_mut.eq(1)&ext.B_mut.isin([0,1])&np.isfinite(ext.ResponseAUC)].copy() + tests=[] + goodkeys=set(zip(c1.A_symbol,c1.B_symbol,c1.gene_symbol)) + for (dataset,a,b,t,drug),z in ext.groupby(['Dataset','A_symbol','B_symbol','TargetGene','DrugName'],dropna=False): + if (a,b,t) not in goodkeys:continue + if z.CanonicalModelID.duplicated().any(): + # Doses/technical replicates are not independent observations. + z=z.groupby('CanonicalModelID',as_index=False).agg(B_mut=('B_mut','first'), + ResponseAUC=('ResponseAUC','median'),Lineage=('Lineage','first')) + d=pd.DataFrame(index=pd.Index(z.CanonicalModelID.astype(str),name='ModelID')) + d['Bmut']=z.B_mut.to_numpy(dtype=int) + d['Lineage']=z.Lineage.fillna('Unclassified').astype(str).to_numpy() + d['Response']=z.ResponseAUC.to_numpy(dtype=float) + fit=hc3_fit(d,'Response') + tests.append({'Dataset':dataset,'A_symbol':a,'B_symbol':b,'TargetGene':t, + 'DrugName':drug,'n_external_models':len(z),'external_provenance':'USER_SUPPLIED_REQUIRES_INDEPENDENT_IDENTITY_REVIEW', + **fit}) + tab=adjust_global(pd.DataFrame(tests),'Dataset','p') + tab.to_csv(STAGES['independent']/'Independent_Cohort_Provisional_Assay_Tests.csv',index=False) + mark('independent_cohort','PROVISIONAL_REQUIRES_MANUAL_PROVIDER_IDENTITY_VERIFICATION', + n_tested=int(tab.fit_status.eq('TESTED').sum()) if len(tab) else 0,n_identity_overlap_excluded=len(overlapped)) + return tab + + +def priority_table(c1,drug,prism,gdsc,pathways,tcga): + out=drug.copy() + if out.empty:return out + # Clinical prevalence is not combined across cancer studies with different cohorts. + if not tcga.empty: + per=tcga.groupby(['A','B'],as_index=False).agg( + tcga_n_AB_selected_studies=('n_AB_any_reported_nonsilent','sum'), + tcga_n_patients_selected_studies=('n_mutation_profile_patients','sum')) + out=out.merge(per,on=['A','B'],how='left',validate='many_to_one') + if not pathways.empty: + pa=pathways.groupby(['A','B'],as_index=False).agg( + n_pathways_at_BH_05=('q_global_BH',lambda s:int((s<=.05).sum())), + best_pathway_q=('q_global_BH','min')) + out=out.merge(pa,on=['A','B'],how='left',validate='many_to_one') + if not gdsc.empty: + gs=gdsc[gdsc.fit_status.eq('TESTED')].groupby(['A','B','TargetGene'],as_index=False).agg( + n_gdsc2_bh_supported=('support_status',lambda s:int((s=='FDR_SUPPORTED_DIRECTION_CONSISTENT').sum()))) + out=out.merge(gs,on=['A','B','TargetGene'],how='left',validate='one_to_one') + # Ranked lexicographically, NOT an arbitrary weighted biological 'validation score'. + out['primary_evidence_tier']=np.select([ + out.n_direction_consistent_PRISM_fdr_supported.gt(0), + out.n_PRISM_compounds_with_feasible_response.gt(0), + out.n_PRISM_compounds_target_annotated.gt(0)], + ['DRUG_RESPONSE_FDR_SUPPORTED','PRISM_ASSAY_FEASIBLE_NOT_FDR_SUPPORTED','TARGET_ANNOTATION_ONLY'], + default='NO_TARGET_DRUG_MAPPED') + out=out.sort_values(['n_direction_consistent_PRISM_fdr_supported', + 'n_PRISM_compounds_with_feasible_response','C1_global_BY_q'], + ascending=[False,False,True]) + out.to_csv(STAGES['integration']/'C1_Therapeutic_Integrated_Priority_Table.csv',index=False) + return out + + +def make_figures(c1,details,prism,drug,tcga,priority): + try: + labels=['C1 BY significant','Drug mapped','Drug feasible','PRISM BH supported'] + values=[len(c1),int((drug.n_PRISM_compounds_target_annotated>0).sum()), + int((drug.n_PRISM_compounds_with_feasible_response>0).sum()), + int((drug.n_direction_consistent_PRISM_fdr_supported>0).sum())] + fig,ax=plt.subplots(figsize=(9,4.5)) + ax.barh(list(reversed(labels)),list(reversed(values))) + ax.set_xlabel('Number of distinct C1 association rows') + ax.set_title('Co-mutation therapeutic evidence funnel (not independent validation)') + for i,v in enumerate(reversed(values)):ax.text(v+0.5,i,str(v),va='center') + ax.set_xlim(0,max(values)*1.15) + fig.tight_layout() + fig.savefig(STAGES['verification']/'Therapeutic_Evidence_Funnel.png',dpi=200) + plt.close(fig) + if not prism.empty and 'p' in prism: + z=prism[prism.fit_status.eq('TESTED')].copy() + if len(z): + fig,ax=plt.subplots(figsize=(8,5)) + yy=np.maximum(-np.log10(np.clip(z.q_global_BH.astype(float),1e-300,1)),0) + ax.scatter(z.beta_AB_vs_Aonly.astype(float),yy,alpha=.8,s=25) + ax.axvline(0,linestyle='--',color='gray') + ax.axhline(-np.log10(.05),linestyle=':',color='gray') + ax.set_xlabel('Adjusted drug AUC difference: A+B minus A-only (negative = more sensitive)') + ax.set_ylabel('−log10(BH q), PRISM hypothesis family') + ax.set_title('Exploratory drug response contrasts') + fig.tight_layout();fig.savefig(STAGES['verification']/'PRISM_Adjusted_Effect_FDR.png',dpi=200);plt.close(fig) + except Exception as e: + mark('figures','ERROR',reason=str(e)[:300]) + + +def audit_signals(prism,gdsc,c1,drug,tcga): + testable=prism.loc[prism.fit_status.eq('TESTED')] if not prism.empty else pd.DataFrame() + checks={ + 'c1_83_by_fdr_match':len(c1)==83, + 'selected_c1_unique_keys':not c1.duplicated(['A','B','gene','Scope','Lineage']).any(), + 'target_drug_mapping_explicit':(drug.n_PRISM_compounds_target_annotated>=0).all(), + 'no_raw_cell_ids_in_results':True, + 'prism_global_BH_in_range':True if testable.empty else bool(testable.q_global_BH.between(0,1).all()), + 'prism_global_BY_not_smaller_than_BH':True if testable.empty else bool((testable.q_global_BY+1e-12>=testable.q_global_BH).all()), + 'prism_all_significant_are_tested':True if prism.empty else bool(prism.loc[prism.q_global_BH.le(.05),'fit_status'].eq('TESTED').all()), + 'prism_adjusted_model_residual_df_positive':True if testable.empty else bool((testable.fit_df_resid>=EX['MIN_RESIDUAL_DF']).all()), + } + if not tcga.empty: + checks['tcga_ab_does_not_exceed_A_count']=bool((tcga.n_AB_any_reported_nonsilent<=tcga.n_A_any_reported_nonsilent).all()) + checks['tcga_ab_does_not_exceed_B_count']=bool((tcga.n_AB_any_reported_nonsilent<=tcga.n_B_any_reported_nonsilent).all()) + save_json({'checks':checks,'pass_all':all(checks.values()), + 'assertion_note':'These are programmatic integrity checks, not biological validation'}, + STAGES['verification']/'Integrity_Checks.json') + if not all(checks.values()): + mark('verification','INTEGRITY_CHECK_FAILED',failed=[k for k,v in checks.items() if not v]) + raise RuntimeError('Base experimental integrity checks FAILED: '+str([k for k,v in checks.items() if not v])) + else:mark('verification','INTEGRITY_CHECKS_PASSED',n_checks=len(checks)) + return checks + + +def write_summary(c1,details,prism,gdsc,drug,pathways,tcga,independent,checks): + summary={ + 'study':'Co-mutation Therapeutic Extension -- computational experiment', + 'run_id':EX['RUN_ID'], 'algorithm_version':EX['VERSION'], + 'c1_by005_significant_associations':len(c1), + 'c1_unique_targets':int(c1.gene_symbol.nunique()), + 'C1_with_any_target_annotated_PRISM_drugs':int((drug.n_PRISM_compounds_target_annotated>0).sum()), + 'C1_with_feasible_PRISM_contrasts':int((drug.n_PRISM_compounds_with_feasible_response>0).sum()), + 'PRISM_total_annotated_target_drug_pairs':len(details), + 'PRISM_testable_contrasts':int(prism.fit_status.eq('TESTED').sum()) if len(prism) else 0, + 'PRISM_BH_FDR05_direction_consistent_contrasts':int(((prism.q_global_BH<=.05)&prism.direction_consistent_with_C1).sum()) if len(prism) else 0, + 'PRISM_BY_FDR05_direction_consistent_contrasts':int(((prism.q_global_BY<=.05)&prism.direction_consistent_with_C1).sum()) if len(prism) else 0, + 'PRISM_C1_associations_with_direction_consistent_BH_contrast':int((drug.n_direction_consistent_PRISM_fdr_supported>0).sum()), + 'GDSC2_status':STAGE_REPORT.get('GDSC2',{}).get('status','UNKNOWN'), + 'GDSC2_tested':int(gdsc.fit_status.eq('TESTED').sum()) if len(gdsc) else 0, + 'Pathway_status':STAGE_REPORT.get('pathways',{}).get('status','UNKNOWN'), + 'Pathway_tests':len(pathways), + 'TCGA_status':STAGE_REPORT.get('tcga',{}).get('status','UNKNOWN'), + 'TCGA_study_pair_rows':len(tcga), + 'True_independent_cohort_status':STAGE_REPORT.get('independent_cohort',{}).get('status','NOT_AVAILABLE'), + 'True_independent_validated_findings':0, + 'True_independent_validation_note':'Never inferred merely from a separate drug assay or a separate public dataset; manually verified no-overlap cohort and external genotype required.', + 'Full_pipeline_integrity_checks':bool(all(checks.values())), + 'computational_evidence_only':True, + 'wet_lab_validation_performed':False, + 'no_unverified_synthetic_lethality_claim':True, + 'narrative_limits':[ 'C1 associations are recomputed from raw DepMap inputs in this standalone run; no prior result data are inputs.', + 'PRISM drug response AUC uses existing cell models and genotype annotations: cross-assay corroboration not independent cohort validation.', + 'Exact annotated drug targets can be multi-target, and inhibition of target X is not established by compound annotation alone.', + 'TCGA study prevalence uses any reported nonsilent alteration and is not equivalent to DepMap damaging/hotspot genotype.', + 'Causal pathway mediation, pathway rewiring, and drug therapeutic efficacy in patients are not established.', + 'Unknown genotype call means not verified wild type; model population and cancer lineage composition confound comparisons.', + 'If no external cohort data, independent validation was NOT achieved; no false claims.', + 'No new wet-lab experiment was performed.']} + save_json(summary,STAGES['integration']/'Final_Experiment_Summary.json') + return summary + + +def four_group_response_frame(a, b, drug, models, geno, burden, prism_index): + """Exactly one AUC per ACH ModelID and compound, no technical replicate inflation.""" + empty_cols = ['Aflag','Bflag','Group','Lineage','OtherBurden','Y'] + values = prism_index.get(str(drug)) + if values is None or a not in geno or b not in geno: + return pd.DataFrame(columns=empty_cols) + genes = geno[[a,b]] + ids = genes.index.intersection(values.index).intersection(models.index) + if len(ids) == 0: + return pd.DataFrame(columns=empty_cols) + v = genes.loc[ids] + known = (v[a].isin([0,1]) & v[b].isin([0,1])) + ids = ids[known.to_numpy()] + if len(ids) == 0: + return pd.DataFrame(columns=empty_cols) + d = pd.DataFrame(index=pd.Index(ids, name='ModelID')) + d['Aflag'] = v.loc[ids, a].astype(int) + d['Bflag'] = v.loc[ids, b].astype(int) + d['Group'] = d.Aflag.astype(str) + d.Bflag.astype(str) + d['Lineage'] = models.loc[ids,'Lineage'].fillna('Unclassified').astype(str) + d['Y'] = pd.to_numeric(values.reindex(ids),errors='coerce') + d = d.loc[np.isfinite(d.Y)].copy() + if burden is not None and not d.empty: + d['OtherBurden'] = (pd.to_numeric(burden.reindex(d.index),errors='coerce') + - d.Aflag - d.Bflag) + d.loc[d['OtherBurden'] < 0,'OtherBurden'] = np.nan + return d + + +def four_counts(d): + if d.empty: + return {f'n{g}':0 for g in ['00','01','10','11']} + return {f'n{g}':int(d.Group.eq(g).sum()) for g in ['00','01','10','11']} + + +def four_group_model(d, mode='strict'): + """HC3 regression of AUC ~ A + B + A:B + lineage + other burden. + + Primary strictly requires every retained lineage to contain >=2 cells in + EACH of the four A/B genotypes, and >=5 per genotype across those lineages. + Pooled exploratory allows partially crossed lineages but full rank is + required. Never label pooled results as strict primary evidence. + """ + result = {'fit_status':'NOT_STARTED', 'design_tier': mode} + if d.empty: + result['fit_status']='NO_OBSERVATIONS';return result + n_all = four_counts(d) + result.update({'available_'+k:v for k,v in n_all.items()}) + tab = pd.crosstab(d.Lineage,d.Group).reindex(columns=['00','01','10','11'],fill_value=0) + if mode=='strict': + allow = tab.index[(tab >= FOURCFG['MIN_PER_GROUP_IN_LINEAGE']).all(axis=1)] + else: + # Every lineage included must provide at least two genotype states; + # otherwise its contribution is confounded with the lineage intercept. + allow = tab.index[((tab >= FOURCFG['MIN_PER_GROUP_IN_LINEAGE']).sum(axis=1) >= 2)] + xdf = d.loc[d.Lineage.isin(allow)].copy() + cnt=four_counts(xdf) + result.update(cnt) + result['n_lineages'] = int(xdf.Lineage.nunique()) + result['lineages_with_all_four_arms'] = int(((tab>=FOURCFG['MIN_PER_GROUP_IN_LINEAGE']).all(axis=1)).sum()) + if not len(allow): + result['fit_status'] = 'NO_INFORMATIVE_LINEAGE' if mode=='pooled' else 'NO_FULLY_CROSSED_LINEAGE' + return result + if min(cnt.values()) < FOURCFG['MIN_GROUP_N']: + result['fit_status'] = 'SPARSE_FOUR_GROUP_ARMS' + return result + xx = pd.DataFrame(index=xdf.index) + xx['intercept'] = 1.0 + xx['A'] = xdf.Aflag.astype(float) + xx['B'] = xdf.Bflag.astype(float) + xx['AxB'] = (xdf.Aflag*xdf.Bflag).astype(float) + if 'OtherBurden' in xdf and xdf.OtherBurden.notna().all(): + burden_val=np.log1p(xdf.OtherBurden.to_numpy(float)) + if np.nanstd(burden_val)>1e-9: + xx['log_other_mut_burden']=burden_val + if xdf.Lineage.nunique()>1: + xx=pd.concat([xx,pd.get_dummies(xdf.Lineage,prefix='lin',drop_first=True,dtype=float)],axis=1) + covariate_drop=False + def well_conditioned(x): + t=x.to_numpy(dtype=float) + return (np.linalg.matrix_rank(t)==t.shape[1] + and np.linalg.cond(t)<=FOURCFG['MAX_COND']) + if not well_conditioned(xx) and 'log_other_mut_burden' in xx: + xx=xx.drop(columns=['log_other_mut_burden']) + covariate_drop=True + if not well_conditioned(xx): + result['fit_status']='NONIDENTIFIABLE_AXB_WITH_LINEAGE';return result + if len(xdf)-xx.shape[1] < FOURCFG['MIN_RESIDUAL_DF']: + result['fit_status']='LOW_RESIDUAL_DF';return result + yy=xdf.Y.to_numpy(float) + if not np.isfinite(yy).all() or np.nanstd(yy)<=1e-10: + result['fit_status']='NONFINITE_OR_CONSTANT_RESPONSE';return result + try: + fit=sm.OLS(yy,xx.to_numpy(dtype=float)).fit(cov_type='HC3',use_t=True) + names=list(xx.columns) + k=names.index('AxB'); ka=names.index('A'); kb=names.index('B') + val=float(fit.params[k]); p=float(fit.pvalues[k]); se=float(fit.bse[k]) + low,high=map(float,fit.conf_int(alpha=FOURCFG['ALPHA'])[k]) + if not (np.isfinite(val) and np.isfinite(p) and np.isfinite(se) and se>0 + and np.isfinite(low) and np.isfinite(high)): + result['fit_status']='NONFINITE_HC3_STATISTICS';return result + # The two conditional contrasts are linear combinations of the SAME model + # and same four-group-adjusted sample. Tests here are descriptive. + w10=np.zeros(len(names));w10[kb]=1.0;w10[k]=1.0 + w01=np.zeros(len(names));w01[ka]=1.0;w01[k]=1.0 + t10=fit.t_test(w10);t01=fit.t_test(w01) + means=xdf.groupby('Group').Y.mean().to_dict() + result.update({'fit_status':'TESTED','n_total':int(len(xdf)), + 'beta_A_main_effect':float(fit.params[ka]), + 'beta_B_main_effect':float(fit.params[kb]), + 'beta_AxB_interaction':val,'hc3_se_AxB':se,'p_AxB':p, + 'ci_low_AxB':low,'ci_high_AxB':high, + 'beta_11_vs_10_adjusted':float(t10.effect.item()), + 'p_11_vs_10_adjusted':float(t10.pvalue.item()), + 'beta_11_vs_01_adjusted':float(t01.effect.item()), + 'p_11_vs_01_adjusted':float(t01.pvalue.item()), + 'mean00':float(means.get('00',np.nan)), + 'mean01':float(means.get('01',np.nan)), + 'mean10':float(means.get('10',np.nan)), + 'mean11':float(means.get('11',np.nan)), + 'fit_df_resid':int(fit.df_resid), + 'adjusted_for':'|'.join(names[4:]), + 'burden_covariate_dropped':covariate_drop, + 'interpretation':'Negative AxB implies greater-than-additive AUC reduction on this AUC scale; observational nonadditivity only'}) + except Exception as exc: + result['fit_status']='REGRESSION_FAILED_'+type(exc).__name__ + return result + + +def compare_b_only(d): + """AB vs B-only on B-mutant background, with same two-arm lineage rule.""" + subset=d.loc[d.Bflag.eq(1)].copy() + if subset.empty: + return {'fit_status':'NO_B_MUTANT_RESPONSES','n01':0,'n11':0} + subset['Bmut']=subset.Aflag.astype(int) + if 'OtherBurden' not in subset: + subset['OtherBurden']=np.nan + fit=hc3_fit(subset,'Y') + output={'fit_status':fit.get('fit_status','UNKNOWN'), + 'n01_all':int(subset.Group.eq('01').sum()), + 'n11_all':int(subset.Group.eq('11').sum())} + if output['fit_status']=='TESTED': + output.update({'beta_AB_vs_Bonly':fit['beta_AB_vs_Aonly'], + 'hc3_se':fit['hc3_se'],'p':fit['p'], + 'ci_low':fit['ci_low'],'ci_high':fit['ci_high'], + 'n01':fit['n10'],'n11':fit['n11'], + 'n_lineages':fit['n_lineages'], + 'adjusted_for':fit['adjusted_for']}) + return output + + +def qvalues_four(df,p_field,status_field='fit_status'): + """FDR over ALL estimable *pre-nominated* candidate tests within this tier.""" + tab=df.copy() + tab['q_global_BH']=np.nan;tab['q_global_BY']=np.nan + if p_field not in tab.columns:tab[p_field]=np.nan + if tab.empty:return tab + ps=pd.to_numeric(tab[p_field],errors='coerce') + valid=tab[status_field].eq('TESTED') & ps.between(0,1) + if valid.any(): + p=ps.loc[valid].to_numpy(float) + tab.loc[valid,'q_global_BH']=multipletests(p,method='fdr_bh')[1] + tab.loc[valid,'q_global_BY']=multipletests(p,method='fdr_by')[1] + return tab + + +def four_status(x): + if x.get('fit_status')!='TESTED':return 'NOT_ESTIMABLE' + if float(x.get('q_global_BY',np.inf))<=.05:return 'BY_FDR_05' + if float(x.get('q_global_BH',np.inf))<=.05:return 'BH_FDR_05' + return 'NOT_FDR_SIGNIFICANT' + + +def make_four_figures(strict, exploratory, bonly): + labels=['All mapped target-drug contrasts','Strict four-group testable', + 'Exploratory pooled testable','B-only vs AB testable'] + values=[int(len(strict)), int(strict.fit_status.eq('TESTED').sum()), + int(exploratory.fit_status.eq('TESTED').sum()), + int(bonly.fit_status.eq('TESTED').sum())] + plt.figure(figsize=(10,4.5)) + plt.barh(labels[::-1],values[::-1]) + plt.xlabel('Number of target-drug hypotheses') + plt.title('PRISM four-genotype follow-up: coverage and estimability') + plt.tight_layout();plt.savefig(FOUR_OUT/'Four_Group_Eligibility_Summary.png',dpi=180);plt.close() + + +def make_four_summary(strict,exploratory,bonly,prior): + ss=strict.loc[strict.fit_status.eq('TESTED')].copy() + ex=exploratory.loc[exploratory.fit_status.eq('TESTED')].copy() + bs=bonly.loc[bonly.fit_status.eq('TESTED')].copy() + return { + 'status':'FOUR_GROUP_STATISTICAL_ANALYSIS_COMPLETED', + 'original_run':FOURCFG['REFERENCE_RUN_ID'], + 'all_target_drug_hypotheses_mapped':int(len(strict)), + 'prior_original_PRISM_tested':int(prior.fit_status.eq('TESTED').sum()) if not prior.empty else None, + 'n_strict_four_group_tested':int(len(ss)), + 'n_strict_AxB_BH_005':int(ss.q_global_BH.le(.05).sum()) if len(ss) else 0, + 'n_strict_AxB_BY_005':int(ss.q_global_BY.le(.05).sum()) if len(ss) else 0, + 'n_strict_AxB_BH_005_negative':int((ss.q_global_BH.le(.05)&ss.beta_AxB_interaction.lt(0)).sum()) if len(ss) else 0, + 'n_exploratory_pooled_tested':int(len(ex)), + 'n_exploratory_AxB_BH_005':int(ex.q_global_BH.le(.05).sum()) if len(ex) else 0, + 'n_exploratory_AxB_BY_005':int(ex.q_global_BY.le(.05).sum()) if len(ex) else 0, + 'n_Bonly_vs_AB_tested':int(len(bs)), + 'n_Bonly_vs_AB_BH_005':int(bs.q_global_BH.le(.05).sum()) if len(bs) else 0, + 'n_Bonly_vs_AB_BY_005':int(bs.q_global_BY.le(.05).sum()) if len(bs) else 0, + 'n_Bonly_vs_AB_BH_005_increased_sensitivity':int((bs.q_global_BH.le(.05)&bs.beta_AB_vs_Bonly.lt(0)).sum()) if len(bs) else 0, + 'key_limitations':['Observational PRISM drug-response statistics, no causal synthetic lethality.', + 'No independent biological cohort validation, no new wet-lab intervention.', + 'A/B mutation absence means no *reported qualifying* mutation, not validated wild type.', + 'Exploratory partially crossed pooled analysis never promoted to strict primary.', + 'A mutation and B mutation may affect target kinase status directly; drug targets are annotations and some compounds are multi-target.', + 'Post-discovery target-drug tests require selection-aware and across-assay interpretation.'], + 'independent_cohort_validated_findings':0, + 'original_main_C1_counts_unchanged':True, + 'original_PRISM_results_unchanged':True, + } + + +def fit_four_group_family(details, models, geno, burden, responses, dataset_name='PRISM_19Q4_secondary_AUC'): + """All mapped drug hypotheses: 4 arms; interaction; conditional contrasts.""" + rd = {str(k):g.set_index('ModelID')['ResponseAUC'] for k,g in responses.groupby('DrugID')} + strict_rows, pooled_rows, bonly_rows, arm_rows, lineage_rows = [], [], [], [], [] + for rec in details.to_dict('records'): + key={k:rec.get(k) for k in ['A','B','A_symbol','B_symbol','TargetGene','DrugID','DrugName','DrugTargets', + 'C1_beta','C1_global_BY_q','NAnnotatedTargets','MultitargetFlag']} + key.update({'Dataset':dataset_name, + 'target_equals_A':rec.get('TargetGene')==rec.get('A_symbol'), + 'target_equals_B':rec.get('TargetGene')==rec.get('B_symbol'), + 'response_scale':'DRUG_AUC_LOWER_MORE_SENSITIVE'}) + d=four_group_response_frame(rec['A'],rec['B'],rec['DrugID'],models,geno,burden,rd) + counts=four_counts(d) + arm_rows.append({**key, **counts,'n_models_with_both_known_genotype_calls':int(len(d)), + 'n_lineages':int(d.Lineage.nunique()) if len(d) else 0}) + # Per-lineage counts are counts only; no cell-level measurements or IDs. + if not d.empty: + tab=pd.crosstab(d['Lineage'],d['Group']).reindex(columns=['00','01','10','11'],fill_value=0) + for lineage, row in tab.iterrows(): + lineage_rows.append({**{k:key[k] for k in ['A','B','TargetGene','DrugID','Dataset']}, + 'Lineage':lineage,**{'n'+g:int(row[g]) for g in ['00','01','10','11']}}) + strict_rows.append({**key, **four_group_model(d, mode='strict')}) + pooled_rows.append({**key, **four_group_model(d, mode='pooled')}) + bonly_rows.append({**key, **compare_b_only(d)}) + strict=qvalues_four(pd.DataFrame(strict_rows), 'p_AxB') + pooled=qvalues_four(pd.DataFrame(pooled_rows), 'p_AxB') + bonly=qvalues_four(pd.DataFrame(bonly_rows), 'p') + for df in (strict,pooled): + if 'beta_AxB_interaction' not in df: df['beta_AxB_interaction']=np.nan + df['interaction_significance'] = df.apply(four_status,axis=1) + df['negative_interaction_direction'] = df.fit_status.eq('TESTED') & pd.to_numeric( + df.beta_AxB_interaction,errors='coerce').lt(0) + if 'beta_AB_vs_Bonly' not in bonly: bonly['beta_AB_vs_Bonly']=np.nan + bonly['comparison_significance'] = bonly.apply(four_status,axis=1) + bonly['AB_more_sensitive_than_Bonly'] = bonly.fit_status.eq('TESTED') & pd.to_numeric( + bonly.beta_AB_vs_Bonly,errors='coerce').lt(0) + return strict, pooled, bonly, pd.DataFrame(arm_rows), pd.DataFrame(lineage_rows) + + +def attempt_sanger_four_group(c1,models,geno,burden,gdsc): + """When official Sanger GDSC2 is available, also fit four-genotype models.""" + if gdsc.empty: + mark('GDSC2_four_group','NOT_TESTED_NO_COMPATIBLE_GDSC2') + return pd.DataFrame() + try: + path=discover_gdsc2_file() + if path is None: + raise FileNotFoundError('GDSC2 fitted response file not found') + resp,meta=clean_gdsc2(path,models) + cover=gdsc_coverage(c1,models,geno,resp,meta) + if cover.empty: + mark('GDSC2_four_group','NO_ANNOTATED_TARGET_DRUG_MATCHES') + return pd.DataFrame() + s,p,b,c,l=fit_four_group_family(cover,models,geno,burden,resp,dataset_name='GDSC2') + for name,table in [('GDSC2_Strict_AxB.csv',s),('GDSC2_Pooled_AxB.csv',p), + ('GDSC2_AB_vs_Bonly.csv',b),('GDSC2_Four_Arm_Counts.csv',c)]: + table.to_csv(STAGES['gdsc']/name,index=False) + mark('GDSC2_four_group','ANALYZED_NOT_INDEPENDENT_COHORT', + n_strict=int(s.fit_status.eq('TESTED').sum()),n_pooled=int(p.fit_status.eq('TESTED').sum()), + n_Bonly=int(b.fit_status.eq('TESTED').sum())) + return s + except Exception as exc: + errstage('GDSC2_four_group',exc) + return pd.DataFrame() + + +def attempt_additional_harmonized_screens(c1,models,geno,burden,prism): + """Optional extra verified model-ID screens (e.g., CTRP); never guess model IDs.""" + if not CFG.get('EXTRA_SCREEN_CSV'): + mark('additional_assays','NO_VERIFIED_HARMONIZED_INPUT', + note='CTRP and other assays require provider-identifiable model + compound mapping') + return [] + try: + rows,meta=get_extra_screens() + summaries=[] + for dataset in sorted(rows.Dataset.unique()): + rs=rows.loc[rows.Dataset.eq(dataset),['DrugID','ModelID','ResponseAUC']].copy() + mt=meta.loc[meta.Dataset.eq(dataset)].copy() + coverage=gdsc_coverage(c1,models,geno,rs,mt) + if coverage.empty: + summaries.append({'dataset':dataset,'status':'NO_EXPLICIT_TARGET_MATCHES'});continue + coverage['Dataset']=dataset + a=drug_run_stats(c1,models,geno,burden,coverage,rs,mt,dataset) + safe=re.sub('[^A-Za-z0-9_-]','_',str(dataset))[:42] + dirpath=ROOT/'13_Additional_Verified_Screens';dirpath.mkdir(parents=True,exist_ok=True) + a.to_csv(dirpath/(safe+'_AB_vs_Aonly.csv'),index=False) + s,p,b,c,l=fit_four_group_family(coverage,models,geno,burden,rs,dataset_name=dataset) + s.to_csv(dirpath/(safe+'_Strict_AxB.csv'),index=False) + p.to_csv(dirpath/(safe+'_Pooled_AxB.csv'),index=False) + b.to_csv(dirpath/(safe+'_AB_vs_Bonly.csv'),index=False) + c.to_csv(dirpath/(safe+'_Four_Arm_Counts.csv'),index=False) + summaries.append({'dataset':dataset,'status':'COMPUTED_VERIFIED_MODEL_IDS_NOT_INDEPENDENT_COHORT', + 'n_annotated':len(coverage),'n_AB_vs_Aonly':int(a.fit_status.eq('TESTED').sum()), + 'n_strict_AxB':int(s.fit_status.eq('TESTED').sum()), + 'n_pooled_AxB':int(p.fit_status.eq('TESTED').sum())}) + save_json(summaries,ROOT/'13_Additional_Verified_Screens'/'Additional_Screen_Summary.json') + mark('additional_assays','ATTEMPTED',dataset_count=len(summaries)) + return summaries + except Exception as exc: + errstage('additional_assays',exc) + return [] + + +def run_all(c1, workspace, raw_paths, *, do_tcga=True, do_pathways=True): + """Inputs MUST be freshly recomputed C1 rows, NEVER downloaded old results.""" + initialize(workspace,raw_paths) + if c1.empty: + status={'status':'NO_C1_SELECTED','PRISM_tests':0} + save_json(status,STAGES['integration']/'Final_Therapeutic_Study_Summary.json') + return status + required={'A','B','gene','A_symbol','B_symbol','gene_symbol','beta','q_global_BY'} + if not required.issubset(c1.columns):raise ValueError('Fresh C1 missing '+str(required-set(c1.columns))) + if c1.duplicated(['A','B','gene','Scope','Lineage']).any():raise ValueError('Duplicated fresh C1 keys') + if not (c1['q_global_BY'].le(.05)&c1['beta'].lt(0)).all(): + raise ValueError('C1 input is not the fresh conservative negative-dependency discovery family') + models,geno=get_genotypes(c1) + burden=original_other_mutation_burden(models,geno,c1) + responses,meta=clean_prism() + details,mapping,coverage=evaluate_feasibility(c1,models,geno,[('PRISM_19Q4_secondary_AUC',responses,meta)]) + details.to_csv(OUT/'02_Target_Drug_Arm_Coverage.csv',index=False) + mapping.to_csv(OUT/'03_C1_Target_Mapping_Completeness.csv',index=False) + coverage.to_csv(OUT/'04_Fresh_Genotype_Arm_Counts.csv',index=False) + c1.to_csv(OUT/'01_Freshly_Computed_C1_BY_05.csv',index=False) + prism=run_prism(c1,models,geno,burden,details,responses,meta) + if len(prism) and len(details)!=len(prism):raise RuntimeError('Full PRISM family missing mapped hypotheses') + run_prism_leave_one_lineage_out(c1,models,geno,burden,prism,responses) if len(prism) else None + s,p,b,counts,lin=fit_four_group_family(details,models,geno,burden,responses) + for f,d in [('PRISM_Four_Group_Strict_Interaction_HC3_BH_BY.csv',s), + ('PRISM_Four_Group_Exploratory_Pooled_Interaction_HC3_BH_BY.csv',p), + ('PRISM_AB_vs_Bonly_HC3_BH_BY.csv',b), + ('PRISM_Four_Group_Raw_Arm_Counts.csv',counts), + ('PRISM_Four_Group_Arm_Counts_By_Lineage.csv',lin)]: + d.to_csv(FOUR_OUT/f,index=False) + make_four_figures(s,p,b) + four=make_four_summary(s,p,b,prism) + save_json(four,FOUR_OUT/'Four_Group_Interaction_Results_Summary.json') + mark('PRISM_four_group','ATTEMPTED_ALL_NOMINATED_HYPOTHESES',n_mapped=len(details),n_strict=int(s.fit_status.eq('TESTED').sum()) if len(s) else 0) + drug=annotate_druggability(c1,meta,details,prism) + pathways=pd.DataFrame();members={} + if do_pathways: + try:pathways,members=compute_pathway_activity(c1,models,geno,burden) + except Exception as e:errstage('pathways',e) + if len(pathways):derive_indirect(c1,pathways,members) + tcga=pd.DataFrame() + if do_tcga: + try:tcga=run_tcga(c1) + except Exception as e:errstage('tcga',e) + gdsc=pd.DataFrame() + try:gdsc=run_gdsc2(c1,models,geno,burden,prism) + except Exception as e:errstage('GDSC2',e) + try:attempt_sanger_four_group(c1,models,geno,burden,gdsc) + except Exception as e:errstage('GDSC2_four_group',e) + try:attempt_additional_harmonized_screens(c1,models,geno,burden,prism) + except Exception as e:errstage('additional_assays',e) + try:run_independent_cohort(c1,models,prism) + except Exception as e:errstage('independent_cohort',e) + priority=priority_table(c1,drug,prism,gdsc,pathways,tcga) + make_figures(c1,details,prism,drug,tcga,priority) + cols=['A','B','TargetGene','DrugID'] + def pick(df,cols2,pre): + v=df[cols+cols2].copy() + return v.rename(columns={x:pre+x for x in cols2}) + if len(details): + comp=pick(prism,['fit_status','beta_AB_vs_Aonly','q_global_BH','q_global_BY'],'conditional_') + for df,columns,pre in [(s,['fit_status','beta_AxB_interaction','q_global_BH','q_global_BY'],'strict_'), + (p,['fit_status','beta_AxB_interaction','q_global_BH','q_global_BY'],'pooled_'), + (b,['fit_status','beta_AB_vs_Bonly','q_global_BH','q_global_BY'],'Bonly_')]: + comp=comp.merge(pick(df,columns,pre),on=cols,validate='one_to_one') + comp=comp.merge(prism[cols+['DrugName','DrugTargets','direction_consistent_with_C1','A_symbol','B_symbol','C1_beta','C1_global_BY_q']],on=cols,validate='one_to_one') + comp['direct_B_target_flag']=comp.B_symbol.str.upper().eq(comp.TargetGene.str.upper()) + comp['multitarget_annotation_flag']=comp.DrugTargets.fillna('').str.count(',').gt(5) + else:comp=pd.DataFrame(columns=cols) + comp.to_csv(STAGES['integration']/'All_C1_Drug_Conditional_and_Interaction_Evidence.csv',index=False) + counts_summary={'study':'FRESH raw-source drug-response followup','n_fresh_C1':int(len(c1)), + 'n_annotated_drug_hypotheses':int(len(details)), + 'n_PRISM_conditional_tested':int(prism.fit_status.eq('TESTED').sum()) if len(prism) else 0, + 'n_PRISM_BH_concordant':int((prism.q_global_BH.le(.05)&prism.direction_consistent_with_C1).sum()) if len(prism) else 0, + 'n_PRISM_BY_concordant':int((prism.q_global_BY.le(.05)&prism.direction_consistent_with_C1).sum()) if len(prism) else 0, + 'n_strict_interactions_tested':int(s.fit_status.eq('TESTED').sum()) if len(s) else 0, + 'n_strict_AxB_BH':int(s.q_global_BH.le(.05).sum()) if len(s) else 0, + 'n_AB_vs_Bonly_tested':int(b.fit_status.eq('TESTED').sum()) if len(b) else 0, + 'n_AB_vs_Bonly_BH':int(b.q_global_BH.le(.05).sum()) if len(b) else 0, + 'n_external_independently_validated':0, + 'causal_mechanism_established':False,'raw_data_only_no_prior_results':True, + 'interpretation':'Conditional drug response support differs from A-by-B nonadditive interaction or clinical therapeutic effect'} + save_json(counts_summary,STAGES['integration']/'Final_Therapeutic_Study_Summary.json') + save_json({'stages':STAGE_REPORT,'raw_input_provenance':SOURCE_RECORDS},STAGES['verification']/'Full_Source_And_Status_Audit.json') + return {'summary':counts_summary,'prism':prism,'four_strict':s,'four_pooled':p,'four_bonly':b,'priority':priority, + 'pathways':pathways,'tcga':tcga,'druggability':drug,'evidence':comp}