{
  "allow_unverified_wt_in_exploratory_analysis": true,
  "alpha": 0.05,
  "batch_A_genes": 24,
  "conditional_estimand": "E[CRISPR X | A=1,B=1] - E[CRISPR X | A=1,B=0]",
  "download_optional_omics": true,
  "drug_estimand": "E[PRISM AUC | A=1,B=1] - E[PRISM AUC | A=1,B=0]",
  "expected_crispr_sigma": 0.45,
  "figshare_article_id": 27993248,
  "figshare_version": 1,
  "genotypes_require_both_matrices": true,
  "gsea_max_size": 300,
  "gsea_min_size": 10,
  "holdout_fraction": 0.2,
  "interaction_auxiliary": "A*B non-additive association, not necessary for conditional estimand",
  "max_condition_number": 1000000000.0,
  "min_enrichment_genes": 5,
  "min_gene_observations": 12,
  "min_overlap_per_lineage_arm": 2,
  "min_per_arm_estimable": 5,
  "min_per_arm_for_four_group": 5,
  "min_reporting_effect_gene": 1,
  "min_residual_df": 8,
  "multiplicity": "Original Simes pair BH / within BH / global gene-context BH, BY dependence sensitivity",
  "mutation_call": "OR(damaging,hotspot); zero is no reported qualifying mutation, NOT verified WT",
  "n_gsea_permutations": 250,
  "pathway_for_discoveries_only": true,
  "pinned_release": "DepMap 24Q4 Public v1 (machine-accessible verified release)",
  "report_top_n": 20,
  "researcher_review": "PENDING",
  "root": "/kaggle/working/final_comutation_fresh_20261104_192636_UTC",
  "run_four_group_interactions": true,
  "run_live": true,
  "run_pan_cancer": true,
  "run_within_lineage": true,
  "save_pair_chunk_rows": 500000,
  "seed": 20261026,
  "source_policy": "Only raw provider releases fetched in this run; never read previous result repositories",
  "target_ci_halfwidth": 0.25,
  "use_mutation_burden_covariate": true
}