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Ectivities", + "5", + "2500 B74 (325).", + "FABM", + "Source: https://www.industrydocuments.ucsf.edu/docs/hpdy0015" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000576.jpg b/idl_wds/doc_00000576.jpg new file mode 100644 index 0000000000000000000000000000000000000000..804546cfeccf83d4833e4763b07c6e146c522800 --- /dev/null +++ b/idl_wds/doc_00000576.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cc4cded955e65456a18cdce057fed2f407318731ffb43b99b61bbe6a64917b91 +size 500872 diff --git a/idl_wds/doc_00000576.json b/idl_wds/doc_00000576.json new file mode 100644 index 0000000000000000000000000000000000000000..cb8ead82d5994feda08b7207a64006a652f2fb6a --- /dev/null +++ b/idl_wds/doc_00000576.json @@ -0,0 +1,664 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.115421, + 0.067473, + 0.269984, + 0.060005 + ], + [ + 0.114741, + 0.161457, + 0.114304, + 0.008538 + ], + [ + 0.114912, + 0.171491, + 0.221665, + 0.008352 + ], + [ + 0.114993, + 0.181761, + 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STEVENS", + "SENIOR VICE PRESIOENT-GENERAL COUNSEL", + "(212) 545-3400", + "November 14, 1989", + "Mr. R.F. Gertenbach", + "The Council for Tobacco", + "Research-U.S.A., Inc.", + "900 Third Avenue", + "New York, NY 10022", + "Dear Bob:", + "I refer to your letter of November 2, 1989 re-", + "questing a contribution to the Special Projects Fund.", + "In accordance with your letter, enclosed is", + "Lorillard's check, in the amount of $11,461, represent-", + "ing our payment to the Fund.", + "Very truly yours,", + "soften", + "AJS/pm", + "Arthur J. Stevens", + "Enclosure", + "EXPONSES", + "LORILLARD, INC.", + "One Park Avenue, New York, NY. 10016-5895", + "Source: https://www.industrydotuments.ucsf.edu/docs/fhnx0032" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000577.jpg b/idl_wds/doc_00000577.jpg new file mode 100644 index 0000000000000000000000000000000000000000..75ac8a0faff969c1db9c5cff3400a9a9ea7290c3 --- /dev/null +++ b/idl_wds/doc_00000577.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4a0a15ea04b8d097235a7f35451a07afd2aef27145bb416e3f6b24972bbec5e0 +size 1005045 diff --git a/idl_wds/doc_00000577.json b/idl_wds/doc_00000577.json new file mode 100644 index 0000000000000000000000000000000000000000..b67affd509f6c9dcad338f644befd77c022e4263 --- /dev/null +++ b/idl_wds/doc_00000577.json @@ -0,0 +1,3030 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.094829, + 0.0, + 0.217104, + 0.010374 + ], + [ + 0.374671, + 0.000151, + 0.152365, + 0.011101 + ], + [ + 0.614318, + 0.002199, + 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Statistics for plant DIET", + "Product - G-WLD297", + "Date - 970131", + "Beginning Time - 0000", + "Ending Time - 2400", + "All physical properties included", + "Beginning Date - 970130", + "Inding Date - 970130", + "Data for Product as Produced", + "All employees included", + "All shifts included", + "PROPERTY", + "TESTS", + "LSL", + "USL", + "TARGIT", + "AVE.", + "STDEV", + "AUNDER", + "LOVER", + "ITOTAL", + "CP", + "CPK", + "A. INTEED PRODUCT TEST DATA", + "MOISTURE", + "'", + "20.47", + "0.383", + "TEMPERATURE", + "$", + "74.3", + "1.21", + "a. FINISHED PRODUCT INDIVIDUAL TEST DATA", + "MOISTURE", + "11", + "14.01", + "1.893", + "TEMPERATURE", + "11", + "79.4", + "1.12", + "RFC", + "11", + "593.5", + "170.51", + "CFC", + "11", + "678.8", + "116.70", + "c. BULKER DATA", + "MOISTURE", + "1", + "14.01", + "CFC", + "1", + "678.8", + "D. FINES DATA", + "FIME $", + "6", + "25.27", + "3.037", + "FINE 10", + "6", + "37.23", + "1.681", + "FINE 14", + "6", + "18.42", + "1.037", + "PASS 14", + "6", + "19.09", + "1.706", + "E. STIN DATA", + "STEM 10+12", + "0.00", + "0.C00", + "STEM 16", + "0.00", + "0.000", + "STEM 20", + "0.00", + "0.000", + "STEM PAN", + "0.00", + "0.000", + "CP . Inherent Capability Index or process potential.", + "(USL - LSL) / (6 . STDEV)", + "Desired value ia > .33", + "CPk - The scaled difference between", + "the process average and the specification limits.", + "The lesser of :", + "(USL - AVE) ! (3 * STDFV)", + "or", + "Post-It\" brand fax transmittal memo 7671", + "ofpages > /", + "(AVE - LSL, / (3 * STDEV)", + "15", + "Desired value is = 1.0", + "ROGER SISK", + "From BOEGE", + "Co.", + "Co.", + "Dept.", + "Phone ,", + "3152", + "983-1356", + "Fax", + "2316", + "Source: https://wwwindustrydocuments.ucsf.edu/docs/gjhg0190" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000578.jpg b/idl_wds/doc_00000578.jpg new file mode 100644 index 0000000000000000000000000000000000000000..12334efda29bec992031a1a41bba377986f52a06 --- /dev/null +++ b/idl_wds/doc_00000578.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a45c967adf1bd623065994b742dcd26a098fecec7ea7fe332deb4635a3858a01 +size 257129 diff --git a/idl_wds/doc_00000578.json b/idl_wds/doc_00000578.json new file mode 100644 index 0000000000000000000000000000000000000000..fcf82d1eaf49c28701a1dfdb68f6fb5962259858 --- /dev/null +++ b/idl_wds/doc_00000578.json @@ -0,0 +1,18570 @@ +{ + 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Stone, Ph. D.", + "D. Heck, Ph.D.", + "Testing Facility: Microbiological Associates Inc.", + "5221 River Road", + "Bethesda, Maryland 20816", + "Technical Staff: David R. Dansie", + "Lloyd C. Campbell", + "Suillerao Martinez", + "Raymond M. David, Ph.D.", + "Study Director:", + "1", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqvc0129", + "Draft Repor t", + "I-5026.401", + "1. DATA PAGE", + "Calvin V. Dove", + "Lana L. 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INTRODUCTION", + "The Cytochroaes P-450 are a group of hemoproteins which are associated", + "with the sicroscaal or lipid portion of a cell. Their designation as P-450", + "resulted from the observed axinua of the reduced hemoprotein-carbo moxoxide", + "complex at 450 na in a difference spectrus (Omura & Sato, 1964). These", + "heaoproteins also have enzyaic activity, and can aetabolize relatively lipophilic", + "substrates to foras which are more water soluble. Such reactions are a", + "normal function of the body and result in the formation of many important", + "hormones. A great variety of non-physiologic compounds (xenobiotics) can", + "also be metabolized by these enzymes, e.g. alkyl halides, aromatic hydrocarbons,", + "aliphatic amines, etc. Such broad substrate specificity is enhanced by", + "the fact that the relative population of isozyaes can be altered by the", + "presence of a potential substrate. Such alterations may increase the amount", + "of only one specific isozyme that metabolizes that substrate, or all P-450", + "activity can be increased uniforaly. In either case, the phenomenon of", + "induction can have important consequences not only to the xenobiotic substrate", + "that induced the activity, but also to physiologic substrates.", + "Of the number of compounds that have been shown to induce P-450, most", + "have tended to fall into one of two categories based on their similarity", + "to two classic inducers: phenobarbital and methylcholanthrene (Snyder and", + "Remmer, 1979). Phenobarbital (PB) induces general P-450 activity, while", + "methylcholanthrene (MC) induces a different type of P-450 called P,-450", + "or P-449, named because of the shift in spectral maximum from 450 to 448", + "nn. Both MC and PB induced foras of P-450 can be induced by certain chlorinated", + "biphenyls such as Aroclor 1254 (Parkinson et al., 1983).", + "A number of reactions have been used to assay P-450 activity. Three", + "primary assays can be eaployed to examine P-450 and P-448 activity.", + "1) -Nitroanisole 0-demethylation - The demethylation of p-nitroanisole", + "has been used as a marker for P-450 activity in the liver (Thurman", + "et al. , 1977).", + "2) 7-Ethoxycoumarin 0-deethylation - The 0-deethylation of 7EC", + "has been shown to be a sensitive marker for P-448 and P-450 induction", + "(Greenlee and Poland, 1978).", + "3) Ethoxyresorufin 0-deethylation - Ethoxyresorufin deethylation", + "is a sensitive marker for P-448 induction in rat liver, kidneys,", + "and lungs (Nias et al., 1984).", + "2", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqvc0129" + ] + }, + { + "bbox": [ + [ + 0.116434, + 0.25423, + 0.658511, + 0.01323 + ], + [ + 0.163808, + 0.239574, + 0.66031, + 0.013701 + ], + [ + 0.223233, + 0.980848, + 0.553315, + 0.01635 + ], + [ + 0.423228, + 0.194772, + 0.113165, + 0.010798 + ], + [ + 0.504292, + 0.91517, + 0.007666, + 0.009437 + ], + [ + 0.642196, + 0.133278, + 0.112822, + 0.013152 + ], + [ + 0.643807, + 0.148402, + 0.093952, + 0.010431 + ] + ], + "poly": [ + [ + { + "X": 0.116434, + "Y": 0.25423 + }, + { + "X": 0.774944, + "Y": 0.25423 + }, + { + "X": 0.774944, + "Y": 0.26746 + }, + { + "X": 0.116434, + "Y": 0.26746 + } + ], + [ + { + "X": 0.163808, + "Y": 0.239574 + }, + { + "X": 0.824118, + "Y": 0.239574 + }, + { + "X": 0.824118, + "Y": 0.253275 + }, + { + "X": 0.163808, + "Y": 0.253275 + } + ], + [ + { + "X": 0.223233, + "Y": 0.980848 + }, + { + "X": 0.776548, + "Y": 0.980848 + }, + { + "X": 0.776548, + "Y": 0.997197 + }, + { + "X": 0.223233, + "Y": 0.997197 + } + ], + [ + { + "X": 0.423228, + "Y": 0.194772 + }, + { + "X": 0.536393, + "Y": 0.194772 + }, + { + "X": 0.536393, + "Y": 0.20557 + }, + { + "X": 0.423228, + "Y": 0.20557 + } + ], + [ + { + "X": 0.504292, + "Y": 0.91517 + }, + { + "X": 0.511958, + "Y": 0.91517 + }, + { + "X": 0.511958, + "Y": 0.924607 + }, + { + "X": 0.504292, + "Y": 0.924607 + } + ], + [ + { + "X": 0.642196, + "Y": 0.133278 + }, + { + "X": 0.755017, + "Y": 0.133278 + }, + { + "X": 0.755017, + "Y": 0.146431 + }, + { + "X": 0.642196, + "Y": 0.146431 + } + ], + [ + { + "X": 0.643807, + "Y": 0.148402 + }, + { + "X": 0.737759, + "Y": 0.148402 + }, + { + "X": 0.737759, + "Y": 0.158833 + }, + { + "X": 0.643807, + "Y": 0.158833 + } + ] + ], + "score": [ + 0.9456, + 0.965, + 0.7816, + 0.8274, + 0.9941, + 0.9918, + 0.9316 + ], + "text": [ + "aterial induces cytochrome P-450 and/or P-448 activity in rat liver.", + "The purpose of this study is to deteraine if orally administered test", + "Source: :ttps://www.industrydocuments.ucsf.edu/docs/fqvc0129", + "111. PURPOSE", + "3", + "Draft Report", + "I-5026.401" + ] + }, + { + "bbox": [ + [ + 0.147954, + 0.296918, + 0.314635, + 0.012233 + ], + [ + 0.217269, + 0.443796, + 0.607729, + 0.014764 + ], + [ + 0.302427, + 0.47403, + 0.342355, + 0.013789 + ], + [ + 0.351301, + 0.53462, + 0.122717, + 0.012706 + ], + [ + 0.31307, + 0.563844, + 0.197456, + 0.013014 + ], + [ + 0.487784, + 0.930026, + 0.007776, + 0.009255 + ], + [ + 0.223132, + 0.98099, + 0.564034, + 0.016204 + ], + [ + 0.244776, + 0.238135, + 0.446591, + 0.012422 + ], + [ + 0.224875, + 0.326595, + 0.285917, + 0.011923 + ], + [ + 0.243881, + 0.356857, + 0.228196, + 0.013128 + ], + [ + 0.282776, + 0.385162, + 0.304763, + 0.012939 + ], + [ + 0.263574, + 0.41542, + 0.266327, + 0.013512 + ], + [ + 0.23686, + 0.503771, + 0.45442, + 0.014489 + ], + [ + 0.227602, + 0.593066, + 0.456878, + 0.014335 + ], + [ + 0.623301, + 0.147656, + 0.113838, + 0.012713 + ], + [ + 0.625833, + 0.163056, + 0.092337, + 0.010766 + ] + ], + "poly": [ + [ + { + "X": 0.147954, + "Y": 0.296918 + }, + { + "X": 0.462589, + "Y": 0.296918 + }, + { + "X": 0.462589, + "Y": 0.309151 + }, + { + "X": 0.147954, + "Y": 0.309151 + } + ], + [ + { + "X": 0.217269, + "Y": 0.443796 + }, + { + "X": 0.824998, + "Y": 0.443796 + }, + { + "X": 0.824998, + "Y": 0.458561 + }, + { + "X": 0.217269, + "Y": 0.458561 + } + ], + [ + { + "X": 0.302427, + "Y": 0.47403 + }, + { + "X": 0.644783, + "Y": 0.47403 + }, + { + "X": 0.644783, + "Y": 0.487818 + }, + { + "X": 0.302427, + "Y": 0.487818 + } + ], + [ + { + "X": 0.351301, + "Y": 0.53462 + }, + { + "X": 0.474018, + "Y": 0.53462 + }, + { + "X": 0.474018, + "Y": 0.547326 + }, + { + "X": 0.351301, + "Y": 0.547326 + } + ], + [ + { + "X": 0.31307, + "Y": 0.563844 + }, + { + "X": 0.510527, + "Y": 0.563844 + }, + { + "X": 0.510527, + "Y": 0.576857 + }, + { + "X": 0.31307, + "Y": 0.576857 + } + ], + [ + { + "X": 0.487784, + "Y": 0.930026 + }, + { + "X": 0.495559, + "Y": 0.930026 + }, + { + "X": 0.495559, + "Y": 0.939281 + }, + { + "X": 0.487784, + "Y": 0.939281 + } + ], + [ + { + "X": 0.223132, + "Y": 0.98099 + }, + { + "X": 0.787166, + "Y": 0.98099 + }, + { + "X": 0.787166, + "Y": 0.997194 + }, + { + "X": 0.223132, + "Y": 0.997194 + } + ], + [ + { + "X": 0.244776, + "Y": 0.238135 + }, + { + "X": 0.691367, + "Y": 0.238135 + }, + { + "X": 0.691367, + "Y": 0.250557 + }, + { + "X": 0.244776, + "Y": 0.250557 + } + ], + [ + { + "X": 0.224875, + "Y": 0.326595 + }, + { + "X": 0.510792, + "Y": 0.326595 + }, + { + "X": 0.510792, + "Y": 0.338518 + }, + { + "X": 0.224875, + "Y": 0.338518 + } + ], + [ + { + "X": 0.243881, + "Y": 0.356857 + }, + { + "X": 0.472077, + "Y": 0.356857 + }, + { + "X": 0.472077, + "Y": 0.369985 + }, + { + "X": 0.243881, + "Y": 0.369985 + } + ], + [ + { + "X": 0.282776, + "Y": 0.385162 + }, + { + "X": 0.587539, + "Y": 0.385162 + }, + { + "X": 0.587539, + "Y": 0.398101 + }, + { + "X": 0.282776, + "Y": 0.398101 + } + ], + [ + { + "X": 0.263574, + "Y": 0.41542 + }, + { + "X": 0.529901, + "Y": 0.41542 + }, + { + "X": 0.529901, + "Y": 0.428931 + }, + { + "X": 0.263574, + "Y": 0.428931 + } + ], + [ + { + "X": 0.23686, + "Y": 0.503771 + }, + { + "X": 0.69128, + "Y": 0.503771 + }, + { + "X": 0.69128, + "Y": 0.51826 + }, + { + "X": 0.23686, + "Y": 0.51826 + } + ], + [ + { + "X": 0.227602, + "Y": 0.593066 + }, + { + "X": 0.68448, + "Y": 0.593066 + }, + { + "X": 0.68448, + "Y": 0.6074 + }, + { + "X": 0.227602, + "Y": 0.6074 + } + ], + [ + { + "X": 0.623301, + "Y": 0.147656 + }, + { + "X": 0.737139, + "Y": 0.147656 + }, + { + "X": 0.737139, + "Y": 0.160369 + }, + { + "X": 0.623301, + "Y": 0.160369 + } + ], + [ + { + "X": 0.625833, + "Y": 0.163056 + }, + { + "X": 0.71817, + "Y": 0.163056 + }, + { + "X": 0.71817, + "Y": 0.173822 + }, + { + "X": 0.625833, + "Y": 0.173822 + } + ] + ], + "score": [ + 0.9495, + 0.9936, + 0.9921, + 0.9948, + 0.9843, + 0.9943, + 0.7827, + 0.9798, + 0.902, + 0.9133, + 0.9821, + 0.9965, + 0.9879, + 0.9952, + 0.9816, + 0.8079 + ], + "text": [ + "Test article Identification: B52", + "Date sample returned: Stored at Microbiological Associates Inc.", + "Description: Clear colorless liquid", + "Purity: 100%", + "Solubility: Corn oil", + "4", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqvc0129", + "IV. TEST ARTICLE IDENTIFICATION AND PROPERTIES", + "Test Article Number: : T05026 A", + "Quantity received: 50 9", + "Date received: October 17, 1995", + "Expiration date: April 1986", + "Storage conditions: Refrigerated (amber bottle)", + "Handling Conditions: Routine safety precautions", + "Draft Report", + "1-5026.401" + ] + }, + { + "bbox": [ + [ + 0.645081, + 0.134568, + 0.117969, + 0.011718 + ], + [ + 0.647653, + 0.149165, + 0.091463, + 0.010901 + ], + [ + 0.39643, + 0.194937, + 0.180885, + 0.010472 + ], + [ + 0.165421, + 0.225124, + 0.632507, + 0.013855 + ], + [ + 0.118399, + 0.240104, + 0.708711, + 0.012456 + ], + [ + 0.11854, + 0.255002, + 0.726671, + 0.013994 + ], + [ + 0.11853, + 0.269766, + 0.678943, + 0.013333 + ], + [ + 0.118906, + 0.284747, + 0.675451, + 0.012832 + ], + [ + 0.119486, + 0.299673, + 0.736064, + 0.013763 + ], + [ + 0.118465, + 0.314481, + 0.708485, + 0.013574 + ], + [ + 0.119596, + 0.32923, + 0.313576, + 0.013942 + ], + [ + 0.166539, + 0.359633, + 0.660079, + 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TEST DESCRIPTION", + "Two groups of rats (8 rats per group) were treated daily by gavage", + "with 2 different concentrations of test material for 4 consecutive days. A", + "control group (8 rats per group) was treated with vehicle only. Dose volumes", + "were based on individual body weights on Day 1. Oral administration of", + "test aterial was the route of administration specified by the Sponsor.", + "A vehicle-control group froa a parallel study was used. These common controls", + "were treated concurrently with the groups receiving test material. Dosing", + "volumes were 6 al/kg body weight.", + "On day 5, all surviving animals were weighed and sacrificed by carbon", + "dioxide asphyxiation. Their livers were excised, washed in cold 1.15% KC1,", + "and weighed. The livers were homogenized in 2 volumes (by weight) of 1.15%", + "KC1, centrifuged at 9,000 x g for 20 minutes, and the supernatants frozen", + "at", + "-70°C until assay The first six animals in each group that exhibited", + "the greatest weight increase during the 4 day dosing period were used for", + "assay. On the day assays were performed, the supernatants wore thawed at", + "room temperature and centrifuged at 100,000 x g for 60 ain. Pellets were", + "resuspended in 1.15% KC1 and assayed for enzyae activity using specific", + "substrates. A posifive control of S9 from animals treated with Araclor 1254", + "was also assayed at the same time to validate the assay procedure.", + "Tissues from", + "5", + "Source: :https://www.industrydocuments.ucsf.edu/docs/fqvc0129" + ] + }, + { + "bbox": [ + [ + 0.645831, + 0.136551, + 0.111598, + 0.012531 + ], + [ + 0.648009, + 0.151184, + 0.092573, + 0.011125 + ], + [ + 0.434502, + 0.196789, + 0.104724, + 0.010722 + ], + [ + 0.118888, + 0.227255, + 0.095821, + 0.010947 + ], + [ + 0.166109, + 0.256973, + 0.650843, + 0.013244 + ], + [ + 0.119621, + 0.271832, + 0.72661, + 0.013011 + ], + [ + 0.119654, + 0.286351, + 0.736812, + 0.013165 + ], + [ + 0.119295, + 0.301365, + 0.679392, + 0.012901 + ], + [ + 0.119142, + 0.316067, + 0.718607, + 0.013118 + ], + [ + 0.120145, + 0.330649, + 0.763376, + 0.013804 + ], + [ + 0.119576, + 0.345769, + 0.736843, + 0.012916 + ], + [ + 0.119807, + 0.360587, + 0.735313, + 0.013245 + ], + [ + 0.12022, + 0.37547, + 0.775419, + 0.01313 + ], + [ + 0.119451, + 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METHODS", + "A. Aniaals", + "Female Sprague-Dawley rats were obtained from Charles River Breeding", + "Laboratories, Kingston, New York at 7 weeks of age. Animals were vaccinated", + "against Sendai virus and quarantined for at least 14 days. Stringent disease", + "control procedures were followed during quarantine to assure the use of", + "healthy aniaals. Rats were observed for signs of illness and cultures from", + "the respiratory tract were examined for the presence of pathogens. In addition,", + "sera from sentinel animals were examined for antibody titers to common rodent", + "virusas and bact a (Reovirus type 3, Pneumonia virus of mice, Sendai virus,", + "Encephalomyelitis nus (6D VII), Mouse adenovirus, Toolan H-1 virus, Mycoplasma", + "pulmonis, Kilham ra: virus, Lymphocytic choriomeningitis virus, Rat coronavirus,", + "Sialodacryoadenitis virus). The animals were judged to be healthy prior to", + "utilization in this study and were 9 weeks old at initiation of dosing.", + "Animals were housed 4 per cage in an AALAC-accredited facility with", + "a controlled environment of 71 + 3°F, 62 + 18% relative humidity, and a", + "12 hour light/dark cycle. Rats were housed in polycarbonate autoclavable", + "cages with filter top cage lids. Corn-cob bedding was used and animals", + "had free access to certified laboratory rodent chow which had been analyzed", + "for environmental contaminants. Water and food wer 2 provided ad libitum.", + "B. Treatment with Test Materials", + "Test material was administered at two dose levels to give information", + "of the dose-response. The doses recommended by the Sponsor for test material", + "852 were 688 mg/kg for the High Dose and 344 ag/kg for the Low Dose. Eight", + "fenale rats per group were given one of two doses by gavage for 4 consecutive", + "days prior to sacrifice. A vehicle control was also included. The vehicle", + "was corn oil . Animals were divided into groups as follows:", + "Dose", + "Treatment", + "Number of Animals", + "High", + "688 mg/kg", + "9 per group", + "Low", + "344 ag/kg", + "8 per group", + "Control", + "vehicle (corn oil)", + "8 per group", + "Dose Preparation:", + "Test material was stored according to Sponsor instructions and routine", + "safety precautions were observed in handling. Test material was prepared", + "in corn oil according to Sponsor instructions. Because of the stability of", + "the aterial as specified by the Sponsor, dosing solutions were prepared in", + "6", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqvc0129" + ] + }, + { + "bbox": [ + [ + 0.642056, + 0.134991, + 0.112896, + 0.012652 + ], + [ + 0.642434, + 0.150015, + 0.093484, + 0.01068 + ], + [ + 0.115712, + 0.195091, + 0.688075, + 0.013429 + ], + [ + 0.114969, + 0.21024, + 0.552569, + 0.011473 + ], + [ + 0.115055, + 0.240878, + 0.064533, + 0.010956 + ], + [ + 0.162619, + 0.270144, + 0.670255, + 0.012708 + ], + [ + 0.115518, + 0.284427, + 0.708053, + 0.013351 + ], + [ + 0.114385, + 0.299006, + 0.68934, + 0.013363 + ], + [ + 0.115688, + 0.314199, + 0.765106, + 0.013192 + ], + [ + 0.11582, + 0.329321, + 0.562414, + 0.013407 + ], + [ + 0.116384, + 0.357965, + 0.122573, + 0.013921 + ], + [ + 0.162916, + 0.388287, + 0.640248, + 0.012874 + ], + [ + 0.11638, + 0.403359, + 0.12276, + 0.010705 + ], + [ + 0.115659, + 0.447521, + 0.200636, + 0.013355 + ], + [ + 0.163381, 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Dosing", + "solutions were stored at 4 °C between dose adainistrations.", + "Volume:", + "The volume of liquid administered to the test animals was 6 al/kg body", + "weight. Daily volumes over the 4 day period were based on individual body", + "weights taken on Day 1. Concentrations were adjusted so that a constant", + "dosing volume was given at both dose levels. The test aterial was administered", + "in a single dose by gavage, using a 16 gauge gavage needle.", + "Body Weights:", + "Animals were weighed prior to treatment on Day 1 and on Day 5 prior", + "to sacrifice.", + "C. Enzyme Preparation", + "On day 5, animals were sacrificed by carbon dioxide asphyxiation.", + "At sacrifice, the liver of each animal was weighed, washed in ice cold 1.15%", + "KC1, and homogenized in 2 volumes (by weight) of 1.15% KC1 using a Polytron", + "homogenizer. All tissues and homogenates were kept at 4°C (on ice) during", + "preparation. Homogenates were centrifuged at 9000 x 9 for 20 minutes using", + "a Sorvall RC2-B or Beckman J2-21 refrigerated centrifuge. Aliquots of the", + "supernatant (S9) were frozen at -70°C until assay. On the day assays were", + "performed, the S9 fractions were thawed at room temperature and centrifuged", + "at 100,000 x g for one hour to prepare aicroscaal pellets. The pellets", + "were resuspended in 10 ml of 1.15% KC1 using 6-8 strokes of a glass-to-glass", + "homogenizer (positive controls resuspended in 5 al of 1.15% KC1).", + "Prior to incubation with substrate, an aliquot of each enzyme preparation", + "was assayed for protein content using the Biuret method described by Layne", + "(1957) and each was diluted with 1.15% KC1 to an appropriate concentration", + "for the assay. All assays were performed in duplicate, and the average", + "absorbance or fluorescence used for the final calculation.", + "D. Assays Used to Assess Enzyme Activity", + "1) p-Nitroanisole 0-demethylase (PNAS)", + "PNAS activity was determined according to the method of Thurman", + "et al. (1977) with modification. 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"(1978) with aodification. Approximately 0.3 ag of aicrosomal", + "protein was incubated with 0.5 umole of 7-ethoxycoumarin in the", + "presence of 0.5 umole NADPH, 0.5 umole NADH, 5 umole MgC12, and", + "65 usole of phosphate buffer at pH 7.4 for 20 minutes. At the", + "termination of the reaction, the product, 7-hydroxycounarin, was", + "extracted into chlorofore and back-extracted into an alkaline", + "aqueous solution. The amount of product was determined fluoro-", + "metrically at an excitation wavelength of 330 na and emission", + "wavelength of 455 na.", + "3) 7-Ethoxyresorufin 0-deethylase (ETR)", + "ETR activity was deterained according to the method of Nims et", + "al. (1984) with modification. Approximately 0.3 ag of aicrosomal", + "protein was incubated with 1.7 aM 7-ethoxyresorufin in the presence", + "of 125 aM NADPH, 25 mM MgCl2, and 0.05 M Tris buffer at pH 7.5.", + "The amount of resorufin produced was determined fluorometrically", + "at an excitation wavelength of 522 na and emission wavelength", + "of 586 na after a 3 minute incubation.", + "Enzyme activity was deterained in vitro using microsomal suspensions", + "from individual rat livers. Activity is expressed as product formed/ag", + "microsomal protein/hour incubation.", + "A positive control was assayed with each group of samples. This positive", + "control consisted of a microsomal suspension prepared on the day of assay", + "from frozen hepatic S9 from Sprague-Dawley rats treated with Aroclor 1254", + "(MAI Catalog #82-150A).", + "CRITERIA FOR A VALID TEST", + "At least 6 animals from each group aust survive dosing before enzyae", + "assays are performed for that group.", + "The positive control should demonstrate enzyme activity that is > 150%", + "of control levels in at least two assays. Assays were repeated in the event", + "that the positive control and the samples strowed ne -induction.", + "failed to demonstrate this degree of", + "EVALUATION OF TEST RESULTS", + "Enzyae activity is presented for individual animals and groups as the", + "quantity of product formed per ag aicrosomal protein per hour incubation", + "time. Group means for each assay were compared by Analysis of Variance", + "and Studentized Range Test (Armitage, 1971). A probability of 0.05 was", + "used to deteraine significance.", + "8", + "Source: ttps://www.industrydocuments.ucsf.edu/docs/fqvc0129" + ] + }, + { + "bbox": [ + [ + 0.644559, + 0.138273, + 0.113485, + 0.012692 + ], + [ + 0.645124, + 0.153362, + 0.095305, + 0.010867 + ], + [ + 0.423228, + 0.199643, + 0.116614, + 0.011068 + ], + [ + 0.16582, + 0.228699, + 0.679435, + 0.014922 + ], + [ + 0.119569, + 0.243973, + 0.715238, + 0.014496 + ], + [ + 0.119905, + 0.258525, + 0.754949, + 0.014769 + ], + [ + 0.12004, + 0.27344, + 0.698096, + 0.013767 + ], + [ + 0.119901, + 0.288072, + 0.679318, + 0.013174 + ], + [ + 0.119215, + 0.302995, + 0.737152, + 0.012692 + ], + [ + 0.119981, + 0.318116, + 0.698725, + 0.014014 + ], + [ + 0.12049, + 0.332987, + 0.716823, + 0.014026 + ], + [ + 0.120038, + 0.349987, + 0.091926, + 0.012288 + ], + [ + 0.167363, + 0.377221, + 0.699968, + 0.014746 + ], + [ + 0.120322, + 0.39226, + 0.689449, + 0.013166 + ], + [ + 0.120619, + 0.406968, + 0.708793, + 0.014864 + ], + [ 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RESULTS", + "Female Sprague Dawley rats were quarantined for 14 days prior to utili-", + "zation, during which time their health status was evaluated by observation.", + "In addition, sentinel animals were sacrificed and cultures from the respiratory", + "tract were examined for pathogens. Sera from sentinel rats were examined", + "for titers to common rodent viruses (see Section VI, Methods). Animals", + "were free of titers to rodent viruses and all animals were vaccinated against", + "Sendai virus. No pathogens were found in the cultures of the respiratory", + "tract, and the animals were judged to be healthy prior to the initiation of", + "the study.", + "Animals were treated with 688 ag/kg, 344 ag/kg B52 in corn oil or vehicle", + "alone (corn oil) for 4 consecutive days. Survival to dosing was 100% in", + "all groups. Body weights on days 1 and 5 are presented in Table 1. These", + "data were used to deteraine which samples were used for subsequent assays.", + "TissueSfrom the first 6 animals in each group to gain the most weight were", + "used for subsequent in vitro assays.", + "Mean liver weights and liver-to-body weight ratios of all animals used", + "for in vitro assays are presented in Table 2. No significant differences", + "were observed in liver weights or liver-to-body weight ratios between the", + "treated and control groups.", + "Enzyme activities from individual animals are presented in Table 3", + "with mean activities presented in Table 4. No significant differencesi", + "PNAS, 7EC or ETR activities were observed between treated and control groups.", + "9", + "Source: :https://www.industrydocuments.ucsf.edu/docs/fqvc0129" + ] + }, + { + "bbox": [ + [ + 0.647389, + 0.139819, + 0.113218, + 0.012931 + ], + [ + 0.649619, + 0.154823, + 0.089131, + 0.010776 + ], + [ + 0.398369, + 0.215288, + 0.16222, + 0.010692 + ], + [ + 0.168564, + 0.245053, + 0.631526, + 0.012628 + ], + [ + 0.121179, + 0.259864, + 0.718025, + 0.01301 + ], + [ + 0.122212, + 0.274957, + 0.726, + 0.012875 + ], + [ + 0.122153, + 0.289258, + 0.764944, + 0.013146 + ], + [ + 0.121145, + 0.304463, + 0.679693, + 0.013237 + ], + [ + 0.122607, + 0.31943, + 0.73597, + 0.013134 + ], + [ + 0.121423, + 0.334207, + 0.706056, + 0.01346 + ], + [ + 0.372872, + 0.350916, + 0.010121, + 0.010571 + ], + [ + 0.150879, + 0.376991, + 0.081745, + 0.015974 + ], + [ + 0.498004, + 0.920478, + 0.016768, + 0.009471 + ], + [ + 0.223151, + 0.980818, + 0.552991, + 0.01636 + ] + ], + "poly": [ + [ + { + "X": 0.647389, + "Y": 0.139819 + }, + { + "X": 0.760607, + "Y": 0.139819 + }, + { + "X": 0.760607, + "Y": 0.15275 + }, + { + "X": 0.647389, + "Y": 0.15275 + } + ], + [ + { + "X": 0.649619, + "Y": 0.154823 + }, + { + "X": 0.73875, + "Y": 0.154823 + }, + { + "X": 0.73875, + "Y": 0.165599 + }, + { + "X": 0.649619, + "Y": 0.165599 + } + ], + [ + { + "X": 0.398369, + "Y": 0.215288 + }, + { + "X": 0.560589, + "Y": 0.215288 + }, + { + "X": 0.560589, + "Y": 0.22598 + }, + { + "X": 0.398369, + "Y": 0.22598 + } + ], + [ + { + "X": 0.168564, + "Y": 0.245053 + }, + { + "X": 0.80009, + "Y": 0.245053 + }, + { + "X": 0.80009, + "Y": 0.257682 + }, + { + "X": 0.168564, + "Y": 0.257682 + } + ], + [ + { + "X": 0.121179, + "Y": 0.259864 + }, + { + "X": 0.839204, + "Y": 0.259864 + }, + { + "X": 0.839204, + "Y": 0.272873 + }, + { + "X": 0.121179, + "Y": 0.272873 + } + ], + [ + { + "X": 0.122212, + "Y": 0.274957 + }, + { + "X": 0.848213, + "Y": 0.274957 + }, + { + "X": 0.848213, + "Y": 0.287832 + }, + { + "X": 0.122212, + "Y": 0.287832 + } + ], + [ + { + "X": 0.122153, + "Y": 0.289258 + }, + { + "X": 0.887097, + "Y": 0.289258 + }, + { + "X": 0.887097, + "Y": 0.302404 + }, + { + "X": 0.122153, + "Y": 0.302404 + } + ], + [ + { + "X": 0.121145, + "Y": 0.304463 + }, + { + "X": 0.800839, + "Y": 0.304463 + }, + { + "X": 0.800839, + "Y": 0.3177 + }, + { + "X": 0.121145, + "Y": 0.3177 + } + ], + [ + { + "X": 0.122607, + "Y": 0.31943 + }, + { + "X": 0.858577, + "Y": 0.31943 + }, + { + "X": 0.858577, + "Y": 0.332564 + }, + { + "X": 0.122607, + "Y": 0.332564 + } + ], + [ + { + "X": 0.121423, + "Y": 0.334207 + }, + { + "X": 0.827478, + "Y": 0.334207 + }, + { + "X": 0.827478, + "Y": 0.347668 + }, + { + "X": 0.121423, + "Y": 0.347668 + } + ], + [ + { + "X": 0.372872, + "Y": 0.350916 + }, + { + "X": 0.382993, + "Y": 0.350916 + }, + { + "X": 0.382993, + "Y": 0.361487 + }, + { + "X": 0.372872, + "Y": 0.361487 + } + ], + [ + { + "X": 0.150879, + "Y": 0.376991 + }, + { + "X": 0.232624, + "Y": 0.376991 + }, + { + "X": 0.232624, + "Y": 0.392965 + }, + { + "X": 0.150879, + "Y": 0.392965 + } + ], + [ + { + "X": 0.498004, + "Y": 0.920478 + }, + { + "X": 0.514772, + "Y": 0.920478 + }, + { + "X": 0.514772, + "Y": 0.929949 + }, + { + "X": 0.498004, + "Y": 0.929949 + } + ], + [ + { + "X": 0.223151, + "Y": 0.980818 + }, + { + "X": 0.776141, + "Y": 0.980818 + }, + { + "X": 0.776141, + "Y": 0.997178 + }, + { + "X": 0.223151, + "Y": 0.997178 + } + ] + ], + "score": [ + 0.99, + 0.8942, + 0.9824, + 0.9966, + 0.9981, + 0.9926, + 0.9898, + 0.9767, + 0.9394, + 0.9515, + 0.9658, + 0.9771, + 0.9978, + 0.8892 + ], + "text": [ + "Draft Report", + "I-5026.401", + "VIII. CONCLUSIONS", + "The criteria for a valid test were satisfied in that 6 animals per", + "group survived dosing and the activity of the positive control was at least", + "1.5 fold above the activity in control samples. Three assays for cytochrome", + "P-450 activity in rat liver were used to compare the effect of two doses of test", + "mater l'al B52 on hepatic enzyme activity. No significant differences in", + "enzyaje activities were observed between treated and control groups. 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David, Ph.D.", + "Initiation Date: 85/10/21", + "Review Completed Date: 85/12/17", + "This study has been divided into a series of phases. Using a", + "random sampling approach, Quality Assurance monitors each of", + "these phases over a series of studies. Procedures, documenta-", + "tion, equipment, etc., are examined in order to assure that the", + "study is performed in accordance with the Good Laboratory", + "Practice regulations and to assure that the study is conducted", + "according to the protocol.", + "The following are the inspection dates, phases inspected, and", + "report dates of QA inspections of the study.", + "INSPECT ON 85/10/18 - 85/10/18,TO STUDY DIR 85/10/18,TO MGMT 85/10/18", + "PHASES: PROTOCOL REVIEW", + "INSPECT ON 85/11/13 - 85/11/13,TO STUDY DIR 85/11/13,TO MGMT 85/12/13", + "PHASES: PNAS DETERMINATION", + "INSPECT ON 85/12/09 - 85/12/12,TO STUDY DIR 85/12/12,T0 MGMT 85/12/17", + "PHASES: DRAFT REPORT", + "This report describes the methods and procedures used in the", + "study and the reported results accurately reflect the raw data", + "of the study.", + "Charter H. 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We're studying people's magazine", + "reading habits, trying to find out how to make magazines more interesting and useful to the public. May I speak to the", + "youngest (man/woman), 18 years old or older, who is at home now?", + "IF THE PERSON: YOU WILL INTERVIEW IS NOT THE PERSON YOU SPOKE TO AT THE DOOR, REINTRODUCE YOURSELF;", + "THEN ASK:", + "1A. Will you please tell me if you have looked thriough any two of the last four issues of: READ APPROPRIATE LIST BELOW.", + "BE SURE TO CHECK MAGAZINES READ.", + "IF TEST", + "ISSUE IS", + "PLAYBOY", + "SPORTS ILLUSTRATED", + "TIME or NEWSWEEK", + "Yes", + "Yes", + "Yes", + "PEAD THIS", + "Argosy", + "1", + "Argosy", + "1", + "Business Week", + "1", + "LIST OF", + "Esquire", + "2", + "Field & Stream", + "2", + "Newsweek", + "2", + "MAGAZINES", + "Oui (\"wee\")", + "3", + "Newswcek", + "3", + "Time", + "3", + "Penthouse", + "4", + "Outdoor Life", + "4", + "U.: S. News & World Report", + "4", + "Playboy", + "5", + "Playboy", + "5", + "Sports Illustrated", + "6", + "Sport", + "6", + "True", + "7", + "Sports Afield", + "7", + "V.I.P.", + "8", + "Sports Illustrated", + "8", + "Time", + "9", + "True", + "0", + "IF NONE OF THE QUALIFYING MAGAZINES IS CHECKED \"YES\", TERMINATE THE INTERVIEW AND CODE \"NQ\"", + "ON THE PLACEMENT CALL RECORD SHEET.", + "1B.", + "I'd like to leave a test copy of", + "for you to look at some time today. Tomorrow I'll call you on the telephone", + "and interview you abouti the magazine. Would you be willing to participate?", + "YES", + "NO", + "IF RESPONDENT IS NOT WILLING TO PARTICIPATE, TERMINATE INTERVIEW AND CODE \"RP\" ON THE PLACEMENT", + "CALL RECORD SHEET. IF RESPONDENT ACCEPTS MAGAZINE, MAKE A MUTUALLY AGREEABLE APPOINTMENT", + "FOR THE FOLLOWING DAY. BE SURE TO RECORD NAME, ADDRESS AND TELEPHONE NUMBER.", + "RESPONDENT'S NAME", + "Miss", + "Mrs.", + "Mr.", + "Area Code & Phone Number", + "ADDRESS", + "CITY & STATE", + "a.n..", + "Time & Date of Telephone Interview", + "p.m.", + "Date", + "Magazine Placed", + "THEN SAY: Please look at this issue as you would normally look at a magazine", + "that is, look at the articles and", + "advertisements which interest you, and skip those that don't. Please do not look at the magazine any time tomorrow,", + "I'll call you tomorrow at", + ".", + "WRITE IN THE APPOINTMENT TIME AND DATE ON THE GALLUP SURVEY", + "ENVELOPE FOR THE RESPONDENT.", + "Could not reach respondent/Respondent did not read test copy. TERMINATE AND RETURN BALLOT TO PRINCETON.", + "Source: https://www.industrydocuments.ucsf.edu/docs/kymk0115" + ] + }, + { + "bbox": [ + [ + 0.955428, + 0.045858, + 0.012052, + 0.009407 + ], + [ + 0.181057, + 0.082222, + 0.387583, + 0.01076 + ], + [ + 0.665669, + 0.08267, + 0.149343, + 0.01034 + ], + [ + 0.044079, + 0.12105, + 0.019482, + 0.025917 + ], + [ + 0.072104, + 0.125618, + 0.012609, + 0.009523 + ], + [ + 0.135001, + 0.125014, + 0.491811, + 0.013068 + ], + [ + 0.658744, + 0.125791, + 0.116246, + 0.011904 + ], + [ + 0.843558, + 0.12641, + 0.017926, + 0.009254 + ], + [ + 0.134542, + 0.140726, + 0.487249, + 0.01095 + ], + [ + 0.072477, + 0.164094, + 0.012412, + 0.009126 + ], + [ + 0.134137, + 0.163655, + 0.336296, + 0.012302 + ], + [ + 0.543833, + 0.164427, + 0.024622, + 0.009457 + ], + [ + 0.627356, + 0.164571, + 0.111768, + 0.011192 + ], + [ + 0.134662, + 0.178889, + 0.809517, + 0.011745 + ], + [ + 0.072295, + 0.202182, + 0.012441, + 0.009361 + ], + [ + 0.134185, + 0.201998, + 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issue I left with you yesterday?", + "Yes (GO TO Q. 3)", + "No", + "IF \"NO\", MAKE A NEW APPOINTMENT FOR TOMORROW, IF POSSIBLE.", + "3.", + "Have you looked at the test issue any. time today?", + "Yes", + "No (GO TO Q. 4)", + "IF \"YES\", FOR THE FIRST TIME, MAKE A NEW APPOINTMENT IF POSSIBLE. OTHERWISE DISCONTINUE INTERVIEW.", + "4.", + "Had you already seen this very same issue before I left a copy with you, or was our copy the first one you had seen?", + "Previously seen", + "Not previously seen", + "5.", + "Thinking now of the test copy I left with you, we'd like to find out what parts you looked at. Here are the titles of some", + "of the articles or features. Please tell me which ones you remember seeing, even though you may not have read them.", + "Incidentally, if. the test copy is nearby, please don't open it up during the interview.", + "HAD READ", + "MOST INTERESTING", + "READ ARTICLES FROM YELLOW SHEET", + "A.", + "B.", + "C.", + "D.", + "E.", + "F.", + "G.", + "H.", + "6.", + "Which article did you find the most interesting?", + "7.", + "Please tell me about one article or picture story you remember seeing. Briefly, what did it look like and what did it say?", + "WRITE ANSWER WORD FOR WORD. PROBE FOR DETAIL.", + "IF RESPONDENT CANNOT DESCRIBE ONE ARTICLE OR PICTURE STORY, DISCONTINUE INTERVIEW.", + "8a.", + "Compared to other magazines of this general type, db you think the quality of the editorial content of", + "(NAME OF TEST ISSUE) is", + "higher than others", + "1", + "about the same as others 02 lower than others 03", + "Dk/NA/Ref. 04", + "8b.", + "Why do you say that?", + "9.", + "In additionto finding out what articles readers saw, we are thying to learn which ads in this test issue people can tecall.", + "We'd like to get your help. As I read off the names of some of the ads in this issue, please tell me whether or noti you", + "recall seeing them. Please say 'yes' for each ad where you can actually recall some part of the illustration or the", + "printing well enough to picture it in your mind.", + "SLOWLY READ ADS FROM YELLOW SHEET. DO NOT READ CODE NUMBERS. REMIND RESPONDENT", + "THAT WE ARE ONLY INTERESTED IN THIS PARTICULAR TEST ISSUE OF THE MAGAZINE.", + "10.", + "Which of the ads that you remembered stands out most clearly in your mind?", + "11.", + "Now I'd like to ask youisome questions about the ads that you mentioned. Most of the questions will be about what the", + "ads looked like and said. Try to concentrate on how the ads looked in this issue rather than other ads for these products", + "you may have seen in earlier issues. Now, thinking of the ad for (Answer to Q. 10)", + "TAKE PLAYBACK ON AD", + "IN QUESTION 10 FIRST. THEN TAKE PLAYBACK ON ALL REMAINING ADS CHECKED \"YES\" ON THE AD LIST. AFTER", + "ALL SHEETS ARE COMPLETED, ASK QUESTIONS ON LAST PAGES OF QUESTIONNAIRE.", + "Source: https://www.industrydocuments.ucsf.edu/docs/kymk0115" + ] + }, + { + "bbox": [ + [ + 0.066745, + 0.112717, + 0.206013, + 0.012529 + ], + [ + 0.066666, + 0.145578, + 0.012137, + 0.009676 + ], + [ + 0.096838, + 0.14351, + 0.171998, + 0.013937 + ], + [ + 0.096934, + 0.159315, + 0.082854, + 0.010325 + ], + [ + 0.096832, + 0.173385, + 0.159688, + 0.014473 + ], + [ + 0.097251, + 0.188639, + 0.169071, + 0.013897 + ], + [ + 0.097447, + 0.204633, + 0.153568, + 0.013205 + ], + [ + 0.096634, + 0.218998, + 0.178504, + 0.011713 + ], + [ + 0.066995, + 0.281881, + 0.012439, + 0.009088 + ], + [ + 0.097008, + 0.280228, + 0.138569, + 0.012307 + ], + [ + 0.067182, + 0.372629, + 0.012867, + 0.008565 + ], + [ + 0.097873, + 0.370903, + 0.147272, + 0.012539 + ], + [ + 0.097538, + 0.385506, + 0.165934, + 0.013357 + ], + [ + 0.098069, + 0.400359, + 0.17505, + 0.01333 + ], + [ + 0.098348, + 0.416336, + 0.050813, + 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What went through your", + "mind when you looked", + "at this ad?", + "(", + "5.", + "The advertiser tried) to", + "Yes", + "increase your interest", + "No", + "in buying his (product/", + "DK", + "service). Did he succeed", + "or not?", + "6.", + "Wihat was in the ad that", + "makes you say that?", + "7.", + "What brand of this type", + "of product did you buy", + "Doesn't use", + "last?", + "OR", + "What company.'s service", + "did you use last?", + "8.", + "Had you ever seen this", + "Yes", + "very saine ad before you", + "No", + "saw it in this issue?", + "DK", + "FOR ADS CODED \"Y\", USE", + "o.x", + "SPECIAL \"Y\" PLAYBACK", + "Y", + "SUFET.", + "BRAND AND PRODUCT", + "(Onty one prochrot fo ., pape)", + "Source: https://www.industrydocuments.ucsf.edu/docs/kymk0115" + ] + }, + { + "bbox": [ + [ + 0.139046, + 0.11061, + 0.595016, + 0.01122 + ], + [ + 0.075123, + 0.172427, + 0.64935, + 0.013776 + ], + [ + 0.075995, + 0.188307, + 0.437732, + 0.012609 + ], + [ + 0.136387, + 0.447522, + 0.050055, + 0.010547 + ], + [ + 0.047051, + 0.504731, + 0.019918, + 0.024601 + ], + [ + 0.076242, + 0.110596, + 0.020127, + 0.009522 + ], + [ + 0.288818, + 0.141806, + 0.014204, + 0.011942 + ], + [ + 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RECORD ANSWERS BELOW.", + "Finally, I would like to ask you a few questions about yourself for classification purposes. As in", + "all Gallup Surveys, your replies will be held in strict confidence.", + "DK/NA", + "(", + "12.", + "b)", + "a)", + "c)", + "13.", + "Do you, yourself, smoke cigarettes? 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Is your total yearly family income", + "READ UNTIL STOPPED", + "DO NOT READ", + "20.", + "And lastly, is your phone number listed or unlisted?", + "Thank you for your cooperation on this survey!", + "RESPONDENT IS:", + "RESPONDENT'S RACE IS:", + "(BY OBSERVATION AT PLACEMENT. DO NOT ASK. )", + "IHEREBY ATTEST THAT THIS IS A BONA: FIDE INTERVIEW ON", + "OBTAINED ACCORDING TO MY INSTRUCTIONS.", + "Interviewer's Signature", + "Time Completed", + "Please stop me at the category that best approximates the total yearly income of all the members", + "Source: :ttps://www.industrydocuments.ucsf.edu/docs/kymk0115", + "Magazine Issue and Date", + "Badge Number", + "AM /", + "PM", + "Date", + "4.", + "Under $7, 000", + "1", + "$7,000 - $9,999", + "2", + "$10,000 - $14, 999", + "3", + "$15,000 - $19, 999", + "4", + "$20,000 - $24, 999", + "5", + "$25,000 - $29, 999", + "6", + "$30, 000 or more", + "7", + "Refused", + "8", + "Don't Know", + "9", + "No Answer", + "0", + "Listed", + "1", + "Unlisted", + "2", + "Man", + "1", + "W.oman", + "2", + "Black", + "1", + "White", + "2", + "Other", + "3", + "19" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000582.jpg b/idl_wds/doc_00000582.jpg new file mode 100644 index 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The", + "* on sobacco advertising", + ": don't think the portents are very", + "B.il would ban all tobacco advertis-", + "follow the acw two-year", + "good.", + "ing except at the point of sale. he", + "any agreemeat. amounced", + "Shadow Health Secretary Stan", + "said.", + "Commons by Health Secrei-", + "Orme demanded an early Com-", + "Jenkin told MPs he had refused", + "srict Jeakia.", + "mons dellate on the new agree-", + "the tobaccoindustry' demands for", + ":", + "acu code was stroagly", + "ment and he warned: \"We si.all", + "à four-year voluntary agreement", + "ed in the Commoes, with", + "certait N be considering :egislation", + "because he did not feel the industry", + "1 himself being only lute-", + "Morns", + "gloomy forecust", + "during the curning months because", + "was prepared to make sufficient", + "in his support for the \"lim-", + "Descriptions of the new code", + "we feei thu oaly by legislation will,", + "concessions.", + "naccssions made by the", + "from angry Opposition MPs in-", + "we achiere positive sesults.'", + "The anti-smoking lobby group", + "HetokJMPsthat", + "cluded \"exceedingly feeble\".", + "Orme also criticised the lack of", + "Action on Smoking and Health", + "sould ob-", + "\"wet\" and \"piddling", + "any reference in the agreement to", + "said the new agreement is \"like the", + "legilitation and would allow", + "Morris, a director of Benton and", + "advertising in sport.", + "Home Guard trying to fight off a", + "Irce voue.", + "Bowles. said: \"I think the odds are", + "Labour MP Laurie Pavitt told", + "auclear attack\".", + "Now stage is set for a COPY BEST", + "tough legal clampdown", + "by Fillary McLaine", + "Industry reaction to the new volua-", + "tary agreement on tobacco adves-", + "tising announced last week has", + "additional funds", + "been a mixture of indifference and", + "cautious satisfaction-despite the", + "ti-smoking", + "fact that it has visibly opened the", + "door to statutory controls when the", + "agreement runs out in July 1982.", + "ive gets", + "The threat of statutory centrols", + "has hung over the industry for the", + "extra £1/m", + "past decade. The initial 30 per cent", + "enforced reduction in poster", + "advertising set out ia the new code", + "Goverament has given", + "is seen by advocates of a total ban", + "QUU IO the Health Education", + "as a feeble gesture towards achiev-", + "al for a new anti-smoking", + "ing their goal.", + "Simpson", + "'there no doubr this is the lasi voluntary agreement", + "age aimed at childrea and", + "The characteristic fervour with", + "legislation anyway. While the", + "David Harris, head of public", + "The moncy.", + "which groups like Action on Smok-", + "tobacco companies accept the", + "affairs at the Advertising Associa-", + "be Department of Health, is", + "ing and Health have been pressing", + "agreement as realistic and work-", + "tion, said: \"All sides of the adver-", + "ation to the council's annual", + "for legislation has not been dam-", + "able. they have voiced concern", + "tising business will understandably", + "from the Ministry of 14.5", + "pened by the terms of the agree-", + "about its curtailed duration.", + "feel frustrated by the probability of", + "The move announced", + "ment. ASH director David Simp-", + "Mac Steel. administration direc-", + "further changes in a mere 18", + "Commoas by Health Minis-", + "son said: There is no doubt in my", + "tor of Philip Morris. said: \"We are", + "months time.", + "Gerard Vaughan. replying", + "mind at all that this is the last", + "disturbed by the shortness of the", + "He challenged the Govern-", + "aestion from Labour Health", + "voluntary agreement.\"", + "agreement as it will affect our", + "ment's \"inconsistency\" in wishing", + "smas Roland Moyle.", + "Although he condemned the", + "long-term planning.\" He denied", + "to continue the shif to low-tar", + "also announced that", + "curbs as \"outrageously pathetic\".", + "there had been dissention among", + "brands but reducing the best", + "mal fuads would be pro-", + "his view is understood to be shared", + "the companies during the pro-", + "means through which to imple.", + "for the same purpose in", + "in Whitehall. where the announce-", + "tracted negotiations to reach the", + "ment brand awareness.", + "ane years Recent Depart-", + "ment. by Health Secretary Patrick", + "agreement. Talks. generally de-", + "The likely outcome of a full.", + "al Health studies show one in", + "Jenkin. is widely regarded as being", + "scribed as a \"hard fight\". have", + "scale poster ban. preceding any", + "x those . ho hecome regular", + "a positive siep towards Govern-", + "lasted nearly a year.", + "restrictions on press advertising.", + ": have started before the", + "ment intervention.", + "The length of this agreement is", + "will force poster contractors to sell", + "micc.", + "The length of the agreement -", + "regarded as a tacit opportunity for", + "harder. with benefits for small to", + "sau per cent of all childrea", + "cut from the previous three-year", + "the media to prepaie for a full-", + "medium-sized agencies able to", + "lo smoke continue to do so", + "term to 20 months - is not much", + "scale poster ban when the agree-", + "take advantage of shorter-term", + "they reach adulthood.", + "longer than it would take to pass", + "ment runs out.", + "commitments.", + "that the new code means to agencies", + "new sobuctu advertising", + "Advertising: The TAC (represent-", + "of the year. The ITPAC has agreed", + "tobacco brand names or designson", + "the Depart-", + "ung home manufactuter) \" ill limit", + "to the principle of alimitation. with", + "goods with special appeal to young", + "or Health. the Totucco", + "spending on cigarette puster", + "terms yet to be agreed.", + "people: cinema ads for cigarettes", + "in Ciramil and the Im-", + "herlising in the 12-month period", + "Other Advernising and Promo-", + "will carry an x certificate.", + "$ Produsts Advis-", + "from I August 1981 in July 1982", + "tion: No media advertising of", + "Government Heulth Wurnings:", + "to alper centotthetevelinthesear", + "cigarettes with a tar yield of 20", + "From the beginning of February", + "- untd 31 Jul. The", + "cading 31 March INSI. In the sear", + "milligrams or more: no TV adver-", + "1981. thrce diffetent warnings will", + "/", + "n will continue is abule by", + "ending 31 July ISSI. assurance has", + "tising of cigara and mpe tobaccos", + "be printed on une thirdof the packs", + "agrecencal and", + "been givca a a ten per cent", + "with the sume name as cigarette", + "of every brand; three different", + "of", + "reJuction un the ket of >pending", + "brands: assurance that manufac-", + "copylines will be included in all", + "alua pants of the acw", + "to 31 March - elfectively repic-", + "advertisements and will take up", + "- are:", + "senting a riper est cut her the sest", + "be discouraged including", + "nine per cent of space.", + "Source:" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000583.jpg b/idl_wds/doc_00000583.jpg new file mode 100644 index 0000000000000000000000000000000000000000..ccef9d8800d40b64dd86c39ef83c822b57cb9df0 --- /dev/null +++ b/idl_wds/doc_00000583.jpg @@ -0,0 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Specifications Complete", + "B.O.M. Complete", + "Materials Delivery (No later than)", + "Factory Trial", + "Production of Sell-in Samples", + "Ship to Sell-in Meetings", + "Sell-in Meetings Begin", + "Production Begins", + "Begin Shipment to Public Warehouses", + "Begin Shipment to Wholesale", + "At Retail", + "OPTION #2", + "Manufacturing location - Louisville", + "The ability to support this production requires the purchase of one (1) new Focke rounded corner complex.", + "The time from rounded corner packer complex commitment to production is approximately fourteen (14)", + "months, which would preclude the ability to support initial production timings. Initial production can be", + "supported by transferring the Richmond Training Center rounded corner packer to Louisville in the second", + "quarter of 1998. The new packer complex would be utilized to backfill the training center packer", + "Doc Code: P0622", + "2086114323", + "Introduction of Virginia Slims Full Flavor Regular and Menthol 100's FTB (Standard square corner box)", + "with an at retail date of September, 1998. The annualized total volume for the two (2) packings is Trad", + "Introduction of Virginia Slims Full Flavor Regular and Menthol 100's FTB Rounded Corner with an at", + "retail date of September, 1998. The annualized total volume for the two (2) packings is", + "Source: https://www.industrydocuments.ucsf.edu/docs/jgjb0183", + "PM USA Trade Secret", + "October 7, 1998", + "e", + "Sea", + "Expense", + "Capital", + "Trade Secret Information", + "Redacted", + "DATE", + "January 19, 1998", + "March 2, 1998", + "March 9, 1998", + "March 13, 1998", + "March 13, 1998", + "April 6, 1998", + "April 13, 1998", + "April 27, 1998", + "July 13, 1998", + "July 31, 1998", + "August 17, 1998", + "August 31, 1998", + "Trade", + "Secret", + "2086114323" + ] + }, + { + "bbox": [ + [ + 0.701638, + 0.069641, + 0.143166, + 0.010103 + ], + [ + 0.170422, + 0.108049, + 0.624258, + 0.017718 + ], + [ + 0.17056, + 0.122944, + 0.236748, + 0.014798 + ], + [ + 0.226979, + 0.13764, + 0.032934, + 0.010103 + ], + [ + 0.551842, + 0.152885, + 0.052396, + 0.009789 + ], + [ + 0.737662, + 0.153403, + 0.04536, + 0.008883 + ], + [ + 0.234783, + 0.164604, + 0.175235, + 0.013688 + ], + [ + 0.546414, + 0.162379, + 0.257575, + 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Additionally, size change and relocation of existing making and packing equipment is", + "required within the Louisville factory.", + "Cost:", + "Expense", + "Capital", + "Machinery Size Change and", + "Trade Secret Information Redacted", + "Movement", + "Training Center Packer to Louisville", + "Focke Packer Purchase and", + "Installation", + "Total", + "The projected timing for this program is the same as the projected timing for the introduction of the", + "standard square box.", + "OPTION #3", + "Conversion of current Virginia Slims Lights Regular and Menthol 100's FTB to Rounded Corner. The", + "annualized total volume for the two (2) packings is approximately", + "Trade", + "based on current forecast of", + "Secret", + "existing VS Lts FTB packings", + "Informa", + "Manufacturing location - Louisville", + "The ability to support this production requires the purchase of two (2) new Focke rounded corner", + "complexes. The time from rounded corner packer complex commitment to production is approximately", + "fourteen (14) months. Production requirements cannot be supported until completion of installation and", + "tune & test of the two new complexes.", + "Cost:", + "Expense", + "Capital", + "Trade Secret Information Redacted", + "Machinery Size Change and", + "Movement", + "Purchase and Install (2) Focke Packers", + "Total", + "The projected timing from date of machinery commitment to At Retail is approximately sixteen (16)", + "months.", + "Concerns:", + "Should the decisions not be made to plan and support Options #2 and Option #3 at the same time,", + "additional machinery moves will be required in the Louisville factory.", + "Doc Code: P0622", + "2086114324", + "2086114324", + "Source: https://www.industrydocuments.ucsf.edu/docs/jgjb0183" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000584.jpg b/idl_wds/doc_00000584.jpg new file mode 100644 index 0000000000000000000000000000000000000000..52b29ad61ad47db554ac32aa9d198c058db9c474 --- /dev/null +++ b/idl_wds/doc_00000584.jpg @@ -0,0 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"Mallinckrodt Pharmaceuticals", + "675 McDonnell Blvd.", + "Hazelwood, MO 63042 I", + "USA", + "T: 314.654.7117 I F: 314.654.3383", + "mhonda.hanne@mallinckrodt.com www.mallinckrodt.com", + "This information may be confidential and/or privileged. Use of this information by anyone other than the intended recipient is prohibited. If you receive this in error, please", + "inform the sender and remove any record of this message.", + "From: Cardetti, Lisa M", + "Sent: Tuesday, October 18, 2016 4:07 PM", + "To: Hanne, Rhonda J", + "Subject: FW: Review Attain Med - Fentanyl Decrease", + "Please send to me once approved to send to customer. Thanks.", + "Lisa Cardetti", + "I Director - National Accounts", + "Mallinckrodt Pharmaceuticals I Specialty Generics", + "675 McDonnell Blvd. I Hazelwood, MO 63042", + "O: 816.214.5286", + "M: 314.452.2845", + "lisa.cardetti@mallinckrodt.com", + "www.mallinckrodt.com", + "This information may be confidential and/or privileged. Use of this information by anyone other than the intended recipient is prohibited. Il you receive this in error, please", + "inform the sender and remove any record of this message.", + "From: Nickelson, Trudy", + "Sent: Tuesday, October 18, 2016 3:30 PM", + "To: Cardetti, Lisa M", + "Subject: FW: Review Attain Med - Fentanyl Decrease", + "Kindest Regards,", + "Trudy", + "Trudy Nickelson", + "/", + "Director .... National Accounts", + "Mallinckrodt Pharmaceuticals / Specialty Generics", + "675 McDonnell Blvd. Hazelwood, MO 63042", + "0:636.271.9414 I M: 636-584-5247", + "trudy.nickelson@mallinckrodt.com", + "www.mallinckrodt.com", + "Source: https://www.industrydocuments.ucsf.edu/docs/fpww0240", + "MNKOI 0002786239" + ] + }, + { + "bbox": [ + [ + 0.185821, + 0.051991, + 0.170545, + 0.019193 + ], + [ + 0.186684, + 0.074346, + 0.168835, + 0.014739 + ], + [ + 0.332661, + 0.096709, + 0.024988, + 0.00658 + ], + [ + 0.11767, + 0.136933, + 0.816104, + 0.010319 + ], + [ + 0.117301, + 0.148231, + 0.382921, + 0.010296 + ], + [ + 0.118127, + 0.182842, + 0.175615, + 0.012523 + ], + [ + 0.117412, + 0.198029, + 0.29168, + 0.013 + ], + [ + 0.117124, + 0.213034, + 0.151191, + 0.012759 + ], + [ + 0.117223, + 0.227798, + 0.356255, + 0.01313 + ], + [ + 0.117999, + 0.260594, + 0.06125, + 0.012426 + ], + [ + 0.118251, + 0.276958, + 0.744985, + 0.012948 + ], + [ + 0.116673, + 0.293829, + 0.052232, + 0.010381 + ], + 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Use of this information by anyone other than the intended recipient is prohibited. If you receive this", + "in error, please inform the sender and remove any record of this message.", + "From: Hanne, Rhonda J", + "Sent: Friday, October 14, 2016 3:34 PM", + "To: Nickelson, Trudy", + "Subject: Review Attain Med - Fentanyl Decrease", + "Hi Trudy", + "Please review the attached and let me know if you approve. l'll then forward on for further approvals.", + "Thanks", + "Rhonda Hanne I Contract Specialist", + "Mallinckrodt Pharmaceuticals", + "675 McDonnell Blvd. Hazelwood, MO 63042", + "I", + "USA", + "T: 314.654.7117 F: 314.654.3383", + "rhonda.hanne@mallinckrodt.com", + "www.mallinckrodt.com", + "This information may be confidential and/or privileged. Use of this information by anyone other than the intended recipient is prohibited. If you receive this in error,", + "please inform the sender and remove any record of this message.", + "Source: ps://www.industrydocuments.ucsf.edu/docs/fpww024", + "MNKOI 0002786240" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000585.jpg b/idl_wds/doc_00000585.jpg new file mode 100644 index 0000000000000000000000000000000000000000..1effc39da2fcc1054c0eb5ba8f349366ca957073 --- /dev/null +++ b/idl_wds/doc_00000585.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4956545260e72f8f8d8f5e3d3e9ac8f68d40e9fbc376b8e87bd0293b07f2f2b3 +size 455698 diff --git a/idl_wds/doc_00000585.json b/idl_wds/doc_00000585.json new file mode 100644 index 0000000000000000000000000000000000000000..fb4d8252c8c0eb60efa2d71373f62d423f8824fe --- /dev/null +++ b/idl_wds/doc_00000585.json @@ -0,0 +1,950 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.438428, + 0.037688, + 0.020122, + 0.017776 + ], + [ + 0.450702, + 0.101629, + 0.02475, + 0.014909 + ], + [ + 0.339976, + 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"Castellot's Grant *2382 entitled \"Growth Regulation in Pulmonary", + "Artery Smooth Muscle Cells\", I placed a call into your Grants", + "Division on February 22, 1991. I was informed that a revised", + "budget in the amount of $60,000.00 had not yet been resubmitted.", + "The enclosed is a full documentation of such, and as you can see it", + "was signed off in December.", + "Please, accept the enclosed for your records and forward the", + "first semi-annual payment for $30,000.00 upon receipt of this", + "letter. If you have any questions, please call me at 617-956-6556.", + "Sincerely,", + "Kanberlyakeid", + "Kimberly Anne Reid", + "Grant Accountant", + "KAR:SSG", + "Enclosure", + "files\\ctrvlis.kar", + "136 Harrison Avenue", + "Boston, Massachusetts 02111", + "617 956-6556", + "50356893" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000586.jpg b/idl_wds/doc_00000586.jpg new file mode 100644 index 0000000000000000000000000000000000000000..7ae273a8c729dc5b51578fafbfe2878d8148a26a --- /dev/null +++ b/idl_wds/doc_00000586.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:738fda484564ea927ab08e47b3e926dda15e79f5b916e770acdc6896eb18aa30 +size 1452146 diff --git a/idl_wds/doc_00000586.json b/idl_wds/doc_00000586.json new file mode 100644 index 0000000000000000000000000000000000000000..1ca9b1a3739c47f3e5158e44641d74135af2a2fd --- /dev/null +++ b/idl_wds/doc_00000586.json @@ -0,0 +1,12446 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.353357, + 0.03027, + 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1983 in a meeting held at Bowman", + "Gray Technical Center to release for mailout through NFO a two-part CAMEL", + "Lights 85 mm. prototype study.", + "Attendees were:", + "Marketing Development", + "Mr. W. P. Whitlatch", + "Ms. M. H. Parham", + "Marketing Development", + "Brand Marketing", + "Mr. A. F. Schramm", + "Brand R & D", + "Mr. H. E. Guess", + "Brand R & D", + "Mr. W. M. Dufour", + "Brand R & D", + "Mr. G. W. Wallace", + "Marketing Development", + "Mr. J. R. Walker", + "Brand Marketing", + "Mr. P. F. Knouse", + "Brand R & D", + "Mr. K. G. Berrier", + "Product identification and description", + "FT 3903-B - Smooth 10 mg. CAMEL Lights 85 mm. product using", + "an efficient filter, high casing, and lower, milder", + "burley.", + "and higher burley.", + "Yew G.Besser", + "Ken G. Berrier", + "i", + "KGB:ams", + "Attachment", + "RJAI FORM 2422-Rev. 7/70", + "FT 3903-C - CAMEL Lights 85 mm. with full tobacco taste 10 mg.", + "product, using an efficient filter, lower casing,", + "Source: https://www.industrydocuments.ucsf.edu/docs/fhhp0223", + "Interoffice Memorandum", + "From:", + "K. G. Berrier", + "Research & Development" + ] + }, + { + "bbox": [ + [ + 0.343127, + 0.141415, + 0.223159, + 0.012702 + ], + [ + 0.127143, + 0.17065, + 0.013874, + 0.007535 + ], + [ + 0.127507, + 0.18716, + 0.014915, + 0.010557 + ], + [ + 0.119707, + 0.200888, + 0.350584, + 0.014441 + ], + [ + 0.148833, + 0.216946, + 0.185879, + 0.014333 + ], + [ + 0.119186, + 0.246727, + 0.167081, + 0.012098 + ], + [ + 0.119032, + 0.276619, + 0.148275, + 0.012102 + ], + [ + 0.119521, + 0.307001, + 0.186207, + 0.012076 + ], + [ + 0.119275, + 0.336128, + 0.158291, + 0.011973 + ], + [ + 0.119538, + 0.366237, + 0.167824, + 0.011613 + ], + [ + 0.119593, + 0.396413, + 0.146906, + 0.011885 + ], + [ + 0.119571, + 0.426075, + 0.157101, + 0.011705 + ], + [ + 0.119425, + 0.455749, + 0.166277, + 0.011745 + ], + [ + 0.119325, + 0.484835, + 0.156815, + 0.012096 + ], + [ + 0.119782, + 0.514815, + 0.137577, + 0.012404 + ], + [ + 0.11954, + 0.544813, + 0.195657, + 0.011991 + ], + [ + 0.119583, + 0.574774, + 0.166085, + 0.012257 + ], + [ + 0.119118, + 0.604533, + 0.157434, + 0.012009 + ], + [ + 0.119061, + 0.633978, + 0.186282, + 0.01198 + ], + [ + 0.226222, + 0.981227, + 0.548116, + 0.016449 + ] + ], + "poly": [ + [ + { + "X": 0.343127, + "Y": 0.141415 + }, + { + "X": 0.566286, + "Y": 0.141415 + }, + { + "X": 0.566286, + "Y": 0.154117 + }, + { + "X": 0.343127, + "Y": 0.154117 + } + ], + [ + { + "X": 0.127143, + "Y": 0.17065 + }, + { + "X": 0.141017, + "Y": 0.17065 + }, + { + "X": 0.141017, + "Y": 0.178185 + }, + { + "X": 0.127143, + "Y": 0.178185 + } + ], + [ + { + "X": 0.127507, + "Y": 0.18716 + }, + { + "X": 0.142422, + "Y": 0.18716 + }, + { + "X": 0.142422, + "Y": 0.197717 + }, + { + "X": 0.127507, + "Y": 0.197717 + } + ], + [ + { + "X": 0.119707, + "Y": 0.200888 + }, + { + "X": 0.470291, + "Y": 0.200888 + }, + { + "X": 0.470291, + "Y": 0.215329 + }, + { + "X": 0.119707, + "Y": 0.215329 + } + ], + [ + { + "X": 0.148833, + "Y": 0.216946 + }, + { + "X": 0.334713, + "Y": 0.216946 + }, + { + "X": 0.334713, + "Y": 0.231278 + }, + { + "X": 0.148833, + "Y": 0.231278 + } + ], + [ + { + "X": 0.119186, + "Y": 0.246727 + }, + { + "X": 0.286267, + "Y": 0.246727 + }, + { + "X": 0.286267, + "Y": 0.258825 + }, + { + "X": 0.119186, + "Y": 0.258825 + } + ], + [ + { + "X": 0.119032, + "Y": 0.276619 + }, + { + "X": 0.267307, + "Y": 0.276619 + }, + { + "X": 0.267307, + "Y": 0.288721 + }, + { + "X": 0.119032, + "Y": 0.288721 + } + ], + [ + { + "X": 0.119521, + "Y": 0.307001 + }, + { + "X": 0.305728, + "Y": 0.307001 + }, + { + "X": 0.305728, + "Y": 0.319078 + }, + { + "X": 0.119521, + "Y": 0.319078 + } + ], + [ + { + "X": 0.119275, + "Y": 0.336128 + }, + { + "X": 0.277566, + "Y": 0.336128 + }, + { + "X": 0.277566, + "Y": 0.348101 + }, + { + "X": 0.119275, + "Y": 0.348101 + } + ], + [ + { + "X": 0.119538, + "Y": 0.366237 + }, + { + "X": 0.287363, + "Y": 0.366237 + }, + { + "X": 0.287363, + "Y": 0.37785 + }, + { + "X": 0.119538, + "Y": 0.37785 + } + ], + [ + { + "X": 0.119593, + "Y": 0.396413 + }, + { + "X": 0.266499, + "Y": 0.396413 + }, + { + "X": 0.266499, + "Y": 0.408299 + }, + { + "X": 0.119593, + "Y": 0.408299 + } + ], + [ + { + "X": 0.119571, + "Y": 0.426075 + }, + { + "X": 0.276671, + "Y": 0.426075 + }, + { + "X": 0.276671, + "Y": 0.43778 + }, + { + "X": 0.119571, + "Y": 0.43778 + } + ], + [ + { + "X": 0.119425, + "Y": 0.455749 + }, + { + "X": 0.285702, + "Y": 0.455749 + }, + { + "X": 0.285702, + "Y": 0.467494 + }, + { + "X": 0.119425, + "Y": 0.467494 + } + ], + [ + { + "X": 0.119325, + "Y": 0.484835 + }, + { + "X": 0.27614, + "Y": 0.484835 + }, + { + "X": 0.27614, + "Y": 0.496932 + }, + { + "X": 0.119325, + "Y": 0.496932 + } + ], + [ + { + "X": 0.119782, + "Y": 0.514815 + }, + { + "X": 0.257359, + "Y": 0.514815 + }, + { + "X": 0.257359, + "Y": 0.527219 + }, + { + "X": 0.119782, + "Y": 0.527219 + } + ], + [ + { + "X": 0.11954, + "Y": 0.544813 + }, + { + "X": 0.315198, + "Y": 0.544813 + }, + { + "X": 0.315198, + "Y": 0.556803 + }, + { + "X": 0.11954, + "Y": 0.556803 + } + ], + [ + { + "X": 0.119583, + "Y": 0.574774 + }, + { + "X": 0.285668, + "Y": 0.574774 + }, + { + "X": 0.285668, + "Y": 0.587031 + }, + { + "X": 0.119583, + "Y": 0.587031 + } + ], + [ + { + "X": 0.119118, + "Y": 0.604533 + }, + { + "X": 0.276552, + "Y": 0.604533 + }, + { + "X": 0.276552, + "Y": 0.616542 + }, + { + "X": 0.119118, + "Y": 0.616542 + } + ], + [ + { + "X": 0.119061, + "Y": 0.633978 + }, + { + "X": 0.305343, + "Y": 0.633978 + }, + { + "X": 0.305343, + "Y": 0.645958 + }, + { + "X": 0.119061, + "Y": 0.645958 + } + ], + [ + { + "X": 0.226222, + "Y": 0.981227 + }, + { + "X": 0.774338, + "Y": 0.981227 + }, + { + "X": 0.774338, + "Y": 0.997676 + }, + { + "X": 0.226222, + "Y": 0.997676 + } + ] + ], + "score": [ + 0.7952, + 0.9322, + 0.573, + 0.9593, + 0.9938, + 0.9968, + 0.9879, + 0.966, + 0.9948, + 0.9908, + 0.9738, + 0.9931, + 0.9887, + 0.9849, + 0.9813, + 0.9966, + 0.994, + 0.9819, + 0.9984, + 0.8656 + ], + "text": [ + "D ISTRIBUTION", + "\"", + "ii", + "Mr. J. D. Phillips/Mr. B. V. Hardin/", + "Mr. D. R. Pugh/File", + "Ms. E. N. Monahan", + "Dr. J. L. Gemma", + "Mr. W. P. Whitlatch", + "Ms. M. H. Parham", + "Mr. A. F. Schramm", + "Mr. H. E. Guess", + "Mr. W. M. Dufour", + "Mr. G. W. Wallace", + "Mr. J. R. Walker", + "Mr. J. S. Self", + "Ms. B. M. Granderson", + "Ms. R. F. Collins", + "Mr. P. F. Knouse", + "Product Review File", + "Source: https://www.industrydocuments.ucsf.edu/docs/thhp0223" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000588.jpg b/idl_wds/doc_00000588.jpg new file mode 100644 index 0000000000000000000000000000000000000000..0eb23e1c3bdd3b39f9695ab39ebb42ebe8093cd1 --- /dev/null +++ b/idl_wds/doc_00000588.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e1a226e59dae7ece2d74feb2463903cb552f7a486deb4fa6a3e82291627cd1bb +size 390118 diff --git a/idl_wds/doc_00000588.json b/idl_wds/doc_00000588.json new file mode 100644 index 0000000000000000000000000000000000000000..7ef8a5a5a616add86fa84434e6cda7bc9ca2fb38 --- /dev/null +++ b/idl_wds/doc_00000588.json @@ -0,0 +1,378 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.664574, + 0.067945, + 0.143572, + 0.016307 + ], + [ + 0.690819, + 0.083879, + 0.120959, + 0.016734 + ], + [ + 0.105442, + 0.137472, + 0.683885, + 0.027333 + ], + [ + 0.103424, + 0.162005, + 0.324098, + 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0.9937, + 0.8289, + 0.8488 + ], + "text": [ + "PHILIP MORRIS MANAGEMENT CORP. INTER-OFFICE CORRESPONDENCE", + "120 PARK AVENUE, NEW YORK, NY 10017-5592", + "To:", + "Distribution", + "Date : August 2, 1995", + "From:", + "Thomas Borelli if", + "Subject : News Articles", + "Attached are recently published articles that are critical of Mr. Waxman and", + "anti-smoking activist, Stanton Glantz.", + "Distribution:", + "l", + "FAX - J. Sollwan", + "J. Boland", + "W. Burrell", + "- 5. Carlson", + "D. Crawford", + "K. Daragan", + "J. Goodheart", + "- Branc/J.Hibbuvella", + "D. Laufer", + "J. Lenzi", + "Note criticism of Glantz", + "R. Marden", + "J. Slavitt", + "re discsssion w/ de la Serna", + "M. Winokur", + "& Salgado. in San Diego", + "Tribune piece", + "2", + "AO- - please distibute to WRA", + "standard list.", + "3", + "f: frund Science.", + "Source: :https://www.industrydocuments.ucsf.edu/docs/kldw0096" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000590.jpg b/idl_wds/doc_00000590.jpg new file mode 100644 index 0000000000000000000000000000000000000000..9be1e924f7b01042f75756fc5ed67be926cca7b9 --- /dev/null +++ b/idl_wds/doc_00000590.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:efdd473ebc482cea4c213992c9f7b889f66219efd3666dfc00b942562582003e +size 201800 diff --git a/idl_wds/doc_00000590.json b/idl_wds/doc_00000590.json new file mode 100644 index 0000000000000000000000000000000000000000..8b6c6c02a58200f665daa270d6c0ba19b03ec025 --- /dev/null +++ b/idl_wds/doc_00000590.json @@ -0,0 +1,430 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.585836, + 0.126828, + 0.104587, + 0.01405 + ], + [ + 0.83938, + 0.136458, + 0.061208, + 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Jim", + "I'll check with Jay to see if Milby is planning to attend morning session. He is going to be at", + "dinner the evening before and will deliver brief welcoming remarks at the dinner. Will also", + "check to see if any other PM USA Sr. Mgt. will be there from Richmond. Denise Keane", + "will be there from NY along with the speakers: JJM, SCP, DN, Eric W., Ellis, Janice,", + "Karen Daragan, Shuanise and Jay Poole." + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000591.jpg b/idl_wds/doc_00000591.jpg new file mode 100644 index 0000000000000000000000000000000000000000..9857d46465f0e84b20040fc5ed126c3e37619a79 --- /dev/null +++ b/idl_wds/doc_00000591.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:19a0f7e3c5080770e025a46a187d9d877f9f53953bffcda9c5973fc2dc3774b2 +size 118641 diff --git a/idl_wds/doc_00000591.json b/idl_wds/doc_00000591.json new file mode 100644 index 0000000000000000000000000000000000000000..98bbe83488ade0252865154d12ff2bbf7ae5f913 --- /dev/null +++ b/idl_wds/doc_00000591.json @@ -0,0 +1,352 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.13096, + 0.214044, + 0.755965, + 0.018241 + ], + [ + 0.150574, + 0.152403, + 0.094635, + 0.01055 + ], + [ + 0.131135, + 0.163263, + 0.034348, + 0.008511 + ], 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0.9927 + ], + "text": [ + "An updated 2002 deck would be fine, and if you can wait til I return on Monday, 9/17 or Tues, 9/18, check my avail", + "Original Message", + "From:", + "Sent:", + "To:", + "Subject:", + "TK", + "with Karen and book it.", + "Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/khkb0055", + "Keim, Tom R.", + "Thursday, September 06, 2001 6:16 PM", + "Marryshow, Karen S.", + "RE: 4th Q recommendation/2002 Mainline Plan" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000592.jpg b/idl_wds/doc_00000592.jpg new file mode 100644 index 0000000000000000000000000000000000000000..ce5f38fe78a3a9a6b422cb9b38d54dfd59254b8c --- /dev/null +++ b/idl_wds/doc_00000592.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:aac5de487979d8a1d77b3d09255a21bf25a25dcda4c899ea2f9bd040520e568b +size 1444043 diff --git a/idl_wds/doc_00000592.json b/idl_wds/doc_00000592.json new file mode 100644 index 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+ 0.995, + 0.996, + 0.9978, + 0.9927, + 0.9975, + 0.9132, + 0.9856, + 0.961, + 0.9935, + 0.6299 + ], + "text": [ + "Building and Construction Urades Council", + "Yours", + "of Alameda", + "Affiliated with the California Labor Federation and the Building and Construction Trades Department", + "the", + "AFL-CIO", + "in.", + "10.", + "8400 ENTERPRISE WAY", + "OAKLAND, CALIFORNIA 94621", + "(415) 430-8664", + "January 1, 1987", + "The Building and Construction Trades Council of Alameda County will be", + "publishing our annual Wage, Rate and Time Directory in 1987. This book", + "will include names, addresses and phone numbers of our local unions, their", + "business representatives, our elected representatives and legislators on", + "the federal, state, county and municipal levels; and relevant information", + "on government agencies. This year a greatly expanded log for recording", + "wage, rate and time data will be included.", + "There will be display space available for those businesses, professionals", + "and contractors who do business with, and seek to do business with, the", + "building trades unions and their membership.", + "Our Wage, Rate and Time book will be prepared and produced by Journeyman", + "Publications and will be mailed to the membership of the building trades", + "locals in Alameda County, as well as to our friends, the people we know", + "and do business with. This will be the only publication of this kind", + "for Alameda County.", + "As you know, our Wage, Rate and Time Directory assists the Trades Council", + "in fighting non-union encroachment on our jobs and our contractors. This", + "book will also assist the building trades in making our voice heard on", + "local issues throughout the coming year as well as in the critical 1988", + "election.", + "This book celebrates the 86th anniversary of the charter of our Council,", + "and I urge your support and participation. If you have any further questions,", + "please call (415) 452-3092, Journeyman Publications.", + "Sincerely,", + "James L. Brown", + "Secretary-Treasurer", + "JLB/cr", + "opeu-29-aflci", + "Source: https://www.industrydocuments.ucsf.edu/docs/fggm0169" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000593.jpg b/idl_wds/doc_00000593.jpg new file mode 100644 index 0000000000000000000000000000000000000000..c04fb83435a3ccec5e5d7d54d6bf9d36243062e6 --- /dev/null +++ b/idl_wds/doc_00000593.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bc723f2c11809edb4e810e88f6427b9f55f48a085d9fafa6ca8a97ed23fc36f2 +size 1237337 diff --git a/idl_wds/doc_00000593.json b/idl_wds/doc_00000593.json new file mode 100644 index 0000000000000000000000000000000000000000..599d295c677fe9958e8c853d112e0eb27307892c --- /dev/null +++ b/idl_wds/doc_00000593.json @@ -0,0 +1,24630 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.318691, + 0.095475, + 0.385562, + 0.01504 + ], + [ + 0.340624, + 0.118612, + 0.34039, + 0.012295 + ], + [ + 0.408314, + 0.155401, + 0.204924, + 0.013493 + ], + [ + 0.328843, 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Pope, Jr.", + "64 Flavoring", + "The following flavor concentrates have conformed to the standards through", + "infrared spectrum, gas chromatography, and organoleptic evaluation.", + "MATERIAL", + "DATE OF MANUFACTURE", + "3-24-76", + "T-14", + "3-24-76", + "T-33", + "T-34", + "3-25-76", + "T-36", + "3-25-76", + "T-43", + "3-30-76", + "3-24-76", + "F-52 Stock Sol.", + "3-24-76", + "T-52", + "3-23-76", + "T-65", + "3-24-76", + "T-67 Lot #1", + "3-24-76", + "T-67 Lot #2", + "4-8-76", + "T-39", + "4-8-76", + "T-40", + "4-8-76", + "T-41", + "4-8-76", + "T-42", + "4-1-76", + "T-13", + "4-1-76", + "T-17", + "4-2-76", + "T-29", + "4-2-76", + "T-64", + "4-6-76", + "T-66", + "4-6-76", + "T-10", + "C.D. McGee, Jr.", + "Development Center", + "SESS", + "RJRI FORM 2422-Rev. 7/70", + "Inter-office Memorandum", + "April 21, 1976", + "Date:", + "From:", + "C.D. 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24", + "Newcastle", + "Monitoring", + "January 24-26", + "London", + "Seminar in Pulmonary Radiology", + "January 24-27", + "Las Vegas", + "24th Annual Meeting of the American Society of Neuroimaging", + "January 25-27", + "Paris", + "Hygiene and Health", + "Weetman D F + Fritsch R", + "January 25-27", + "Tucson", + "Oncogenomics - Dissecting Cancer through Genome Research", + "January 25-28", + "Tucson", + "Functional Genomics", + "Maui", + "Molecular Biology and New Therapeutic Strategie - Cancer", + "February 12-16", + "Research in the 21st Century", + "February 14-16", + "London", + "4th International Symposium on Experimental Rhinology &", + "Weetman D F", + "Immunology of the Nose", + "February 15-19", + "San Francisco", + "AAAS Annual Meeting & Science Innovation Exhibition", + "Healthy, not Sick Buildings: How to make your Buildings more", + "February 21", + "Yeovil", + "Leslie G", + "Healthy", + "Feb. 25-March 1", + "Incline Village", + "Genetic Modifiers of Cancer 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Central and Eastern Europe", + "April 18-19", + "Manchester", + "International Conference on Monitoring Indoor Air Pollution", + "Therapeutic Role of Cytokine and Chemokine Inhibitors in", + "April 22-24", + "Porto", + "Immune Diseases", + "April 22-28", + "Veyrier-du-Lac", + "Infection and Cancer - Second IARC International Course", + "Tenerife", + "Bioactive Compounds in Plant Foods - Health Effects and", + "April 26-28", + "Perspectives for the Food Industry", + "April 26-30", + "Halkidiki", + "4th International Congress on Lung Cancer", + "May 3", + "Salisbury", + "DERA Symposium - Lung Deposition & Clearance", + "May 8", + "Manchester", + "Fitler Media - Science or Black Art?", + "May 8-12", + "Bialystok", + "Endocrine Disruptors (EDS) and Carcinogenic Risk Assessment", + "May 9-13", + "Berlin", + "The XXth Congress of the European Academy of Allergology", + "Weetman D F", + "and Clinical Immunology", + "May 10-11", + "Arlington", + "Reducing Tobacco Harm Conference", + "May 10-11", + "Berlin", + "European Conference on Smoke Free Workplaces", + "Weinberg", + "69ème Assemblée Annuelle de la Société Suisse de Médecine", + "May 10-12", + "Lausanne", + "Interne", + "PM3009173133", + "Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/kzgy0149" + ] + }, + { + "bbox": [ + [ + 0.326379, + 0.068501, + 0.321172, + 0.009203 + ], + [ + 0.0674, + 0.073968, + 0.053121, + 0.009393 + ], + [ + 0.221239, + 0.074026, + 0.063685, + 0.009119 + ], + [ + 0.326524, + 0.079716, + 0.136176, + 0.007624 + ], + [ + 0.067125, + 0.090729, + 0.036856, + 0.009218 + ], + [ + 0.223744, + 0.090957, + 0.059568, + 0.008675 + ], + [ + 0.327221, + 0.090802, + 0.132022, + 0.007459 + ], + [ + 0.06757, + 0.10735, + 0.036518, + 0.009291 + ], + [ + 0.230413, + 0.107449, + 0.045158, + 0.009066 + ], + [ + 0.32689, + 0.107331, + 0.318481, + 0.009442 + ], + [ + 0.327276, + 0.124163, + 0.296117, + 0.007702 + ], + [ + 0.067323, + 0.129409, + 0.036426, + 0.009753 + ], + [ + 0.230876, + 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Jahrestagung der Deutschen Arbeitsgemeinschaft für", + "Epidemiologie (DAE)", + "British Association for Lung Cancer - Old and New Occupational", + "September 6-8", + "Leuven", + "Exposures and the Lung", + "Occupational Health and Public Health - Lessons from the Past", + "September 6-9", + "Norrköping", + "Challenges for the Future", + "September 7-8", + "Leuven", + "Old and New Occupational Exposures and the Lung", + "September 8-11", + "Copenhagen", + "Air Distribution in Rooms", + "PM3009173134", + "Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/kzgy0149" + ] + }, + { + "bbox": [ + [ + 0.327187, + 0.068426, + 0.284943, + 0.009492 + ], + [ + 0.067372, + 0.079236, + 0.079244, + 0.009572 + ], + [ + 0.229011, + 0.079543, + 0.048237, + 0.007347 + ], + [ + 0.326934, + 0.079562, + 0.292394, + 0.009662 + ], + [ + 0.69568, + 0.079582, + 0.060506, + 0.007434 + ], + [ + 0.327084, + 0.090942, + 0.117218, + 0.008994 + ], + [ + 0.066631, + 0.102123, + 0.080001, + 0.008722 + ], + 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+ "Successful Drug Development", + "January 26", + "Balham", + "Air Conditioning 2000 Plus : Greener air conditioning for the next", + "century", + "January 26-30", + "Dana Point", + "Transcription Factor Pathogenesis of Cancer at the Millennium", + "6th Annual Meeting of the Society for Research on Nicotine and", + "February 18-20", + "Arlington", + "Tobacco", + "February 23-24", + "London", + "Health Effects of Vehicle Emissions", + "Leslie G", + "February 23-25", + "Tenerife", + "1st International Conference on Occupational Risk Prevention", + "March 2-4", + "Princeton", + "International Conference on Advances in Cancer Immunotherapy", + "March 8", + "Aberdeen", + "New Approaches to Common Problems in the Next Millenium", + "March 15-16", + "London", + "Ultrafine Particles in the Atmosphere", + "March 19-23", + "Philadelphia", + "Society of Toxicology's 39th Annual Meeting", + "March 22", + "Birmingham", + "Dampness in Buildings: Diagnosis and Health Implications", + "Leslie G", + 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+ "April 11-13", + "Manchester", + "Occupational Hygiene 2000 - Promoting a Healthy Working", + "Environment", + "April 12", + "Strasbourg", + "Pollens Particules Pollution", + "April 12-14", + "Porto", + "Nutritionists meet Food Scientists and Technologists", + "April 13-14", + "Leeds", + "International Sustainable Development Research Conference", + "Hoskins JA", + "2000", + "Journées Nationales de la Société Française d' Alergologie et", + "April 13-15", + "Strasbourg", + "d'Immunologie Clinique", + "April 18", + "Bristol", + "Inflammation Control A Goal for the Millenium", + "April 18-19", + "Manchester", + "International Conference on Monitoring Indoor Air Pollution", + "April 28", + "Liverpool", + "Heritage Mycology - Managing the Health of our Heritage", + "May 2-5", + "Amsterdam", + "20th International Congress of the EAPCCT", + "May 8-11", + "Brussels", + "The Toxicology Forum 2000 European Meeting", + "Leslie G", + "International Symposium on Cleaning for Health : Professional", + "May 11-12", + "Amsterdam", + "cleaning and its relation", + "to occupational health", + "Mechanisms of Cell Death and Disease: Advances in", + "May 13-17", + "Dublin", + "Therapeutic Intervention", + "EMBL / SALK/EMBO Conference on Oncogenes and Growth", + "May 13-17", + "Heidelberg", + "Control", + "May 14-19", + "Aby (Norrköping)", + "Principles of Etiology / Etiognostic Research", + "May 15", + "Balham", + "Operating Natural Ventilation - BSRIA / CISBE Joint Seminar", + "May 17", + "London", + "Particles and Air Quality", + "Hoskins JA", + "Poertschach", + "Österreichische Lebensmittelchemiker Tage (Austrian Foodstuff", + "May 17-19", + "HER / DOL", + "Chemists Conference)", + "May 18", + "Newark", + "Mechanisms of Toxicity / Modes of Action in Risk Assessment", + "Pecs", + "Co-Operation and Collaboration for the Health of Rural", + "May 25-27", + "Communities", + "May 26-31", + "Dubrovnik", + "2nd Intenational Conference on Signal Transduction", + "PM3009173138", + "Source: ttp://industrydocuments.library.ucsf.edu/tobacco/docs/kzgy0149" + ] + }, + { + "bbox": [ + [ + 0.066944, + 0.073985, + 0.044721, + 0.007423 + ], + [ + 0.222926, + 0.073979, + 0.039357, + 0.007607 + ], + [ + 0.30825, + 0.068447, + 0.296706, + 0.009162 + ], + [ + 0.660064, + 0.073989, + 0.02499, + 0.007526 + ], + [ + 0.308698, + 0.079717, + 0.036256, + 0.007749 + ], + [ + 0.067467, + 0.090853, + 0.044498, + 0.007448 + ], + [ + 0.224612, + 0.090788, + 0.035386, + 0.007573 + ], + [ + 0.308215, + 0.090672, + 0.158352, + 0.009158 + ], + [ + 0.067402, + 0.101941, + 0.044251, + 0.007628 + ], + [ + 0.221943, + 0.102033, + 0.040679, + 0.009184 + ], + [ + 0.308773, + 0.10193, + 0.133639, + 0.009439 + ], + [ + 0.067097, + 0.11306, + 0.044711, + 0.007772 + ], + [ + 0.230961, + 0.113345, + 0.02323, + 0.007389 + ], + [ + 0.308222, + 0.113096, + 0.227436, + 0.0092 + ], + [ + 0.067265, + 0.124617, + 0.044409, + 0.007476 + ], + [ + 0.21884, + 0.124504, + 0.047626, + 0.007691 + ], + [ + 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"TITLE: The Effect of Cigarette Paper Porosity and Preperforated Tipping", + "Paper Hole Size on Cigarette Ventilation and Smoke Delivery", + "AUTHORS: R. A. Hyde*", + "AFFILIATION: Celanese Fibers Marketing Company, P. 0. Box 32414,", + "Charlotte, NC 28232", + "ABSTRACT: Tipping paper permeability and plugwrap porosity are two variables most commonly", + "considered in the ventilation of a cigarette. However, two additional vari-", + "ables, cigarette paper porosity and preperforated tipping paper hole size, have", + "been found to have a significant effect on total cigarette dilution and smoke", + "delivery. Cigarette papers varying in porosity from 25 to 200 CORESTA units", + "were evaluated with filter constructions ventilated from 20 to 80%. It was", + "found that a linear relationship exists between tip dilution and total cigarette", + "dilution for any given cigarette paper porosity with the slope of the line", + "dependent upon cigarette paper porosity. The effect of varying cigarette paper", + "porosity on smoke chemistry was also evaluated. To determine the effect", + "of", + "preperforated tipping paper hole size on filter dilution and smoke deliveries,", + "micro and macrolaser perforated tipping papers ranging in permeability from 400", + "to 4000 CORESTA units were evaluated with filter constructions ventilated from", + "10 to. 80%. By varying tipping paper hole size at constant permeability, it was", + "found that the effective area of a filter submitted to ventilation can have a", + "significant effect on the amount of filter ventilation achieved. Since smallier", + "perforations require more holes than large perforations to achieve the same", + "permeability level, the effective area of the filter exposed to ventilation is", + "l'arger, yielding a higher percent dilution. The effects of tipping paper hole", + "size on smoke chemistry were also evaluated.", + "REVIEW: For several years Celanese has been working on a model to predict cigarette ven-", + "tilation levels based on the porosities of the components comprising the", + "product. The permeability of the plugwrap and perforated tipping paper have", + "been evaluated previously. In this presentation the author considered the ad-", + "ditional variables of the rod paper porosity and the tipping paper vent size.", + "In a semiempirical analysis, Ms. Hyde has shown that the ventilation level of a", + "full-length, unlit cigarette can be accurately predicted from the individual", + "contributions of the plugwrap, tipping paper, and rod paper. A linear relation-", + "ship was observed between the total ventilation from all sources and the tip", + "ventilation. The role of the vent size on dilution was also investigated. At a", + "constant permeability level, the tipping paper hole size was varied. It was", + "determined that smaller vents give a larger total ventiliation than larger ones", + "I", + "at the same tipping paper permeability. The effects of ventilation on smoke", + "chemistry were also presented.", + "-Reviewed by R. Dwyer", + "I", + "L", + "Source:" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000598.jpg b/idl_wds/doc_00000598.jpg new file mode 100644 index 0000000000000000000000000000000000000000..06d2b2aa7251c3535f36dcbf07e2fa64c3187f14 --- /dev/null +++ b/idl_wds/doc_00000598.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0525ac2f1c65a44d163fdeb48342ec3896e477972c7b87a57c3edbe8fbb0e4cd +size 574386 diff --git a/idl_wds/doc_00000598.json b/idl_wds/doc_00000598.json new file mode 100644 index 0000000000000000000000000000000000000000..ac9028f9d7ee5750929692dae617e70c846b7631 --- /dev/null +++ b/idl_wds/doc_00000598.json @@ -0,0 +1,2868 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.375849, + 0.103545, + 0.218244, + 0.018241 + ], + [ + 0.281447, + 0.129314, + 0.407518, + 0.0162 + ], + [ + 0.199601, + 0.16819, + 0.132218, + 0.014927 + ], + [ + 0.19943, + 0.208911, + 0.007123, + 0.003241 + ], + [ + 0.257125, + 0.202712, + 0.149705, + 0.012854 + ], + [ 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"2635", + "Source: https://www.industrydocuments.ucsf.edu/docs/gibd0100" + ] + } + ] +} \ No newline at end of file diff --git a/idl_wds/doc_00000599.jpg b/idl_wds/doc_00000599.jpg new file mode 100644 index 0000000000000000000000000000000000000000..b541b2b98c0a525cf2c39d2c7ad8e651f8a79526 --- /dev/null +++ b/idl_wds/doc_00000599.jpg @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b6db26e8879ea34e144cddab80f9a750e2cf51eab536e445047dad9da2210ff8 +size 1870034 diff --git a/idl_wds/doc_00000599.json b/idl_wds/doc_00000599.json new file mode 100644 index 0000000000000000000000000000000000000000..6545d4a390f2a60a9ebd82e0b8328b4909faa9f6 --- /dev/null +++ b/idl_wds/doc_00000599.json @@ -0,0 +1,804 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.306374, + 0.173745, + 0.030061, + 0.10074 + ], + [ + 0.334878, + 0.174916, + 0.030512, + 0.126106 + ], + [ + 0.033417, + 0.191347, + 0.013332, + 0.207665 + ], + [ + 0.048239, + 0.218095, + 0.014192, + 0.177729 + ], + [ + 0.017949, + 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