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NOT FOR PUBLIC DISSEMINATION", + "TO:", + "All Employees", + "DATE: July 7, 1999", + "FROM:", + "Geoff Bible", + "SUBJECT: Plaintiffs Win Case Against Philip Morris; Verdict Will Be Appealed", + "Today a jury in Miami ruled against Philip Morris Incorporated and several other tobacco companies", + "in the first phase of the Engle class-action smoking and health lawsuit. Today's verdict does not find", + "any company liable to any individual smoker and does not require any tobacco company to pay", + "damages to any plaintiff.", + "While the decision was disappointing, it was not unexpected at this initial phase of the trial. No", + "monetary damages for any individual are involved at this point, and we think we have numerous and", + "excellent grounds for even this preliminary setback to be overturned on appeal.", + "After a year-long trial, this is only the first step in what has been, and what will be, a long process.", + "This class-action trial has been divided into three separate phases. Today is merely the conclusion of", + "the first phase, during which the jury was not allowed to consider evidence about the choices smokers", + "make. This phase examined only a limited number of issues that may be relevant in determining", + "whether the companies are liable with respect to any particular smoker.", + "Unfortunately, the judge in this case imposed a gag order on us at the start which remains in effect", + "today and does not allow us to defend ourselves in the media or even to set the record straight.", + "However, it does not prevent me from reporting to you.", + "The Engle case was the first tobacco class-action lawsuit to go to trial and, legally, that should not", + "have been allowed to happen. Most state and federal courts, including the U.S. Supreme Court, have", + "ruled that lawsuits like this case where numerous individual issues predominate for each plaintiff are", + "simply not suitable for a class-action trial.", + "Under the court's rules, the nine named plaintiffs in the case now must present evidence regarding", + "their claims involving proof of their alleged injuries as a result of smoking and the same jury will", + "consider those claims. We will have every opportunity for the first time during those cases to present", + "our full defenses to the individual claims.", + "We do not know at this time when the second phase of the trial will begin, but we anticipate it will be", + "in the near future.", + "After those nine individual trials are concluded, the case will go into its third and final phase. In that", + "phase, other class members could present the facts of their individual claims to the court and, again,", + "we will be able to defend ourselves. Clearly, this trial is a long way from conclusion.", + "(MORE)", + "Source: https://www.industrydocuments.ucsf.edu/docs/gqdg0061" + ] + }, + { + "bbox": [ + [ + 0.093267, + 0.137853, + 0.743623, + 0.01454 + ], + [ + 0.09381, + 0.155156, + 0.745574, + 0.014863 + ], + [ + 0.093524, + 0.17249, + 0.718932, + 0.014627 + ], + [ + 0.09386, + 0.18935, + 0.737752, + 0.01481 + ], + [ + 0.093551, + 0.206366, + 0.639758, + 0.01426 + ], + [ + 0.093811, + 0.240452, + 0.703216, + 0.014319 + ], + [ + 0.09409, + 0.257061, + 0.727319, + 0.01423 + ], + [ + 0.093563, + 0.273833, + 0.698413, + 0.014706 + ], + [ + 0.0937, + 0.291459, + 0.091092, + 0.013873 + ], + [ + 0.093341, + 0.325326, + 0.289026, + 0.014261 + ], + [ + 0.459367, + 0.375348, + 0.038145, + 0.011902 + ], + [ + 0.216419, + 0.981304, + 0.568114, + 0.016593 + ] + ], + "poly": [ + [ + { + "X": 0.093267, + "Y": 0.137853 + }, + { + "X": 0.83689, + "Y": 0.137853 + }, + { + "X": 0.83689, + "Y": 0.152393 + }, + { + "X": 0.093267, + "Y": 0.152393 + } + ], + [ + { + "X": 0.09381, + "Y": 0.155156 + }, + { + "X": 0.839384, + "Y": 0.155156 + }, + { + "X": 0.839384, + "Y": 0.170019 + }, + { + "X": 0.09381, + "Y": 0.170019 + } + ], + [ + { + "X": 0.093524, + "Y": 0.17249 + }, + { + "X": 0.812457, + "Y": 0.17249 + }, + { + "X": 0.812457, + "Y": 0.187117 + }, + { + "X": 0.093524, + "Y": 0.187117 + } + ], + [ + { + "X": 0.09386, + "Y": 0.18935 + }, + { + "X": 0.831612, + "Y": 0.18935 + }, + { + "X": 0.831612, + "Y": 0.20416 + }, + { + "X": 0.09386, + "Y": 0.20416 + } + ], + [ + { + "X": 0.093551, + "Y": 0.206366 + }, + { + "X": 0.733309, + "Y": 0.206366 + }, + { + "X": 0.733309, + "Y": 0.220626 + }, + { + "X": 0.093551, + "Y": 0.220626 + } + ], + [ + { + "X": 0.093811, + "Y": 0.240452 + }, + { + "X": 0.797027, + "Y": 0.240452 + }, + { + "X": 0.797027, + "Y": 0.254772 + }, + { + "X": 0.093811, + "Y": 0.254772 + } + ], + [ + { + "X": 0.09409, + "Y": 0.257061 + }, + { + "X": 0.821409, + "Y": 0.257061 + }, + { + "X": 0.821409, + "Y": 0.271291 + }, + { + "X": 0.09409, + "Y": 0.271291 + } + ], + [ + { + "X": 0.093563, + "Y": 0.273833 + }, + { + "X": 0.791976, + "Y": 0.273833 + }, + { + "X": 0.791976, + "Y": 0.288539 + }, + { + "X": 0.093563, + "Y": 0.288539 + } + ], + [ + { + "X": 0.0937, + "Y": 0.291459 + }, + { + "X": 0.184793, + "Y": 0.291459 + }, + { + "X": 0.184793, + "Y": 0.305332 + }, + { + "X": 0.0937, + "Y": 0.305332 + } + ], + [ + { + "X": 0.093341, + "Y": 0.325326 + }, + { + "X": 0.382367, + "Y": 0.325326 + }, + { + "X": 0.382367, + "Y": 0.339587 + }, + { + "X": 0.093341, + "Y": 0.339587 + } + ], + [ + { + "X": 0.459367, + "Y": 0.375348 + }, + { + "X": 0.497512, + "Y": 0.375348 + }, + { + "X": 0.497512, + "Y": 0.387249 + }, + { + "X": 0.459367, + "Y": 0.387249 + } + ], + [ + { + "X": 0.216419, + "Y": 0.981304 + }, + { + "X": 0.784534, + "Y": 0.981304 + }, + { + "X": 0.784534, + "Y": 0.997896 + }, + { + "X": 0.216419, + "Y": 0.997896 + } + ] + ], + "score": [ + 0.9981, + 0.9984, + 0.999, + 0.9988, + 0.9968, + 0.9977, + 0.9981, + 0.9983, + 0.9973, + 0.999, + 0.9868, + 0.7805 + ], + "text": [ + "While no one likes to lose, even if the loss may be temporary, I would remind you that we have had", + "many recent positive developments on the litigation front. Within the past two months, the industry", + "has won five jury verdicts in four individual smoking and health cases and in one case involving", + "exposure to environmental tobacco smoke. These verdicts reinforce our belief that there are strong", + "defenses to these claims and we look forward to presenting them in the Phase II trials.", + "As for the Engle case, I can assure you every legal step will be taken at the appropriate time to", + "overturn this decision. We will seek to have today's preliminary verdict, along with other rulings", + "made by this court, reviewed by the appellate courts in Florida at the earliest legally available", + "opportunity.", + "Thank you for your continued support.", + "# # #", + "Source: https://www.industrydocuments.ucsf.edu/docs/gqdg0061" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004219.json b/doc_00004219.json new file mode 100644 index 0000000000000000000000000000000000000000..6311cd0d069eb7c9e378d005eb88355c825100b4 --- /dev/null +++ b/doc_00004219.json @@ -0,0 +1,1402 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.1652, + 0.143234, + 0.131528, + 0.009294 + ], + [ + 0.422797, + 0.163136, + 0.1561, + 0.00984 + ], + [ + 0.28435, + 0.185619, + 0.44996, + 0.011197 + ], + [ + 0.201946, + 0.230974, + 0.024034, + 0.007925 + ], + [ + 0.114457, + 0.343064, + 0.045909, + 0.011442 + ], + [ + 0.114799, + 0.373107, + 0.709565, + 0.014289 + ], + [ + 0.117148, + 0.38728, + 0.647646, + 0.014764 + ], + [ + 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P. O. Box 35090-Louisville, . Kentucky 40232", + "use", + "Dear", + "As we have discussed, Brown & Williamson Tobacco Corporation", + "(\"B&W\") desires to retain your services as a scientific", + "consultant regarding various aspects of B&W's grooved cigarette", + "filter technology. This letter agreement is to confirm our", + "mutual understanding with respect to the terms and conditions", + "under which B&W and you (\"Consultant\") agree to enter into a", + "working relationship. An additional purpose of this agreement", + "is to protect the confidential and proprietary interests of B&W.", + "n.", + "Consultant agrees that during the term of this agreement he", + "will consult with and provide information to B&W appropriate to", + "the field of this agreement. B&W agrees to pay Consultant for", + "services actually rendered a fee at the rate of $", + "per", + "hour/day [cross out inapplicable word]. In addition, B&W shall", + "reimburse Consultant for all reasonable and necessary", + "out-of-pocket expenses actually incurred, including those for", + "travel, food, and lodging in connection with the performance of", + "services hereunder. All payments by B&W will be made monthly", + "after receipt of Consultant's itemized invoices.", + "It is recognized that as a result of the performance of", + "services hereunder, the parties may agree that it would be", + "appropriate to undertake specific research projects. The scope", + "of any such project and the fee therefor will be separately", + "negotiated between the parties and are not a part of this", + "agreement.", + "Unless otherwise authorized in writing by B&W, Consultant", + "agrees to maintain in confidence any information pertaining to", + "this agreement provided by B&W. The parties acknowledge that", + "any data or information generated or arising out of the", + "consulting work performed by B&W by Consultant is the property" + ] + }, + { + "bbox": [ + [ + 0.10448, + 0.998188, + 0.081212, + 0.001673 + ], + [ + 0.11104, + 0.112638, + 0.693299, + 0.017369 + ], + [ + 0.111588, + 0.127457, + 0.729015, + 0.016233 + ], + [ + 0.111374, + 0.142884, + 0.172111, + 0.01589 + ], + [ + 0.110586, + 0.174687, + 0.646536, + 0.016415 + ], + [ + 0.110962, + 0.189073, + 0.69473, + 0.015957 + ], + [ + 0.111799, + 0.204619, + 0.465828, + 0.016127 + ], + [ + 0.450908, + 0.236652, + 0.197581, + 0.014382 + ], + [ + 0.45151, + 0.26674, + 0.306846, + 0.012145 + ], + [ + 0.462637, + 0.281679, + 0.131068, + 0.012065 + ], + [ + 0.451229, + 0.342405, + 0.022604, + 0.014634 + ], + [ + 0.109308, + 0.371727, + 0.010546, + 0.012864 + ], + [ + 0.108737, + 0.40278, + 0.101712, + 0.012067 + ], + [ + 0.109349, + 0.463796, + 0.021817, + 0.014104 + ], + [ + 0.109544, + 0.493892, + 0.045874, + 0.011435 + ], + [ + 0.221371, + 0.980833, + 0.564087, + 0.016545 + ], + [ + 0.475328, + 0.070669, + 0.01103, + 0.011606 + ] + ], + "poly": [ + [ + { + "X": 0.10448, + "Y": 0.998188 + }, + { + "X": 0.185692, + "Y": 0.998188 + }, + { + "X": 0.185692, + "Y": 0.999861 + }, + { + "X": 0.10448, + "Y": 0.999861 + } + ], + [ + { + "X": 0.11104, + "Y": 0.112638 + }, + { + "X": 0.804339, + "Y": 0.112638 + }, + { + "X": 0.804339, + "Y": 0.130006 + }, + { + "X": 0.11104, + "Y": 0.130006 + } + ], + [ + { + "X": 0.111588, + "Y": 0.127457 + }, + { + "X": 0.840603, + "Y": 0.127457 + }, + { + "X": 0.840603, + "Y": 0.143689 + }, + { + "X": 0.111588, + "Y": 0.143689 + } + ], + [ + { + "X": 0.111374, + "Y": 0.142884 + }, + { + "X": 0.283485, + "Y": 0.142884 + }, + { + "X": 0.283485, + "Y": 0.158774 + }, + { + "X": 0.111374, + "Y": 0.158774 + } + ], + [ + { + "X": 0.110586, + "Y": 0.174687 + }, + { + "X": 0.757122, + "Y": 0.174687 + }, + { + "X": 0.757122, + "Y": 0.191102 + }, + { + "X": 0.110586, + "Y": 0.191102 + } + ], + [ + { + "X": 0.110962, + "Y": 0.189073 + }, + { + "X": 0.805691, + "Y": 0.189073 + }, + { + "X": 0.805691, + "Y": 0.205029 + }, + { + "X": 0.110962, + "Y": 0.205029 + } + ], + [ + { + "X": 0.111799, + "Y": 0.204619 + }, + { + "X": 0.577628, + "Y": 0.204619 + }, + { + "X": 0.577628, + "Y": 0.220746 + }, + { + "X": 0.111799, + "Y": 0.220746 + } + ], + [ + { + "X": 0.450908, + "Y": 0.236652 + }, + { + "X": 0.648489, + "Y": 0.236652 + }, + { + "X": 0.648489, + "Y": 0.251033 + }, + { + "X": 0.450908, + "Y": 0.251033 + } + ], + [ + { + "X": 0.45151, + "Y": 0.26674 + }, + { + "X": 0.758357, + "Y": 0.26674 + }, + { + "X": 0.758357, + "Y": 0.278886 + }, + { + "X": 0.45151, + "Y": 0.278886 + } + ], + [ + { + "X": 0.462637, + "Y": 0.281679 + }, + { + "X": 0.593706, + "Y": 0.281679 + }, + { + "X": 0.593706, + "Y": 0.293744 + }, + { + "X": 0.462637, + "Y": 0.293744 + } + ], + [ + { + "X": 0.451229, + "Y": 0.342405 + }, + { + "X": 0.473833, + "Y": 0.342405 + }, + { + "X": 0.473833, + "Y": 0.357039 + }, + { + "X": 0.451229, + "Y": 0.357039 + } + ], + [ + { + "X": 0.109308, + "Y": 0.371727 + }, + { + "X": 0.119853, + "Y": 0.371727 + }, + { + "X": 0.119853, + "Y": 0.384591 + }, + { + "X": 0.109308, + "Y": 0.384591 + } + ], + [ + { + "X": 0.108737, + "Y": 0.40278 + }, + { + "X": 0.210448, + "Y": 0.40278 + }, + { + "X": 0.210448, + "Y": 0.414848 + }, + { + "X": 0.108737, + "Y": 0.414848 + } + ], + [ + { + "X": 0.109349, + "Y": 0.463796 + }, + { + "X": 0.131167, + "Y": 0.463796 + }, + { + "X": 0.131167, + "Y": 0.4779 + }, + { + "X": 0.109349, + "Y": 0.4779 + } + ], + [ + { + "X": 0.109544, + "Y": 0.493892 + }, + { + "X": 0.155418, + "Y": 0.493892 + }, + { + "X": 0.155418, + "Y": 0.505327 + }, + { + "X": 0.109544, + "Y": 0.505327 + } + ], + [ + { + "X": 0.221371, + "Y": 0.980833 + }, + { + "X": 0.785457, + "Y": 0.980833 + }, + { + "X": 0.785457, + "Y": 0.997378 + }, + { + "X": 0.221371, + "Y": 0.997378 + } + ], + [ + { + "X": 0.475328, + "Y": 0.070669 + }, + { + "X": 0.486358, + "Y": 0.070669 + }, + { + "X": 0.486358, + "Y": 0.082275 + }, + { + "X": 0.475328, + "Y": 0.082275 + } + ] + ], + "score": [ + 0.4283, + 0.9966, + 0.9993, + 0.9808, + 0.9985, + 0.9996, + 0.9865, + 0.9971, + 0.9964, + 0.9983, + 0.9987, + 0.8969, + 0.958, + 0.9978, + 0.9991, + 0.8259, + 0.9958 + ], + "text": [ + "--", + "of B&W and shall be kept in confidence by Consultant. This", + "obligation of confidentiality shall survive the termination of", + "this agreement.", + "If the above is acceptable to you, please indicate your", + "acceptance by signing and dating the duplicate copies where", + "indicated and returning one copy to B&W.", + "Very truly yours,", + "BROWN & WILLIAMSON TOBACCO", + "CORPORATION", + "By", + "/", + "ACCEPTED:", + "By", + "Date", + "Source: https://www.industrydocuments.ucsf.edu/docs/jmpj0137", + "2" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004220.json b/doc_00004220.json new file mode 100644 index 0000000000000000000000000000000000000000..3d718c8dd4cc07f0efafdaac0897728085e8de63 --- /dev/null +++ b/doc_00004220.json @@ -0,0 +1,924 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.059114, + 0.047775, + 0.087203, + 0.01107 + ], + [ + 0.058869, + 0.066796, + 0.039286, + 0.009265 + ], + [ + 0.164989, + 0.066112, + 0.236012, + 0.011978 + ], + [ + 0.058463, + 0.081549, + 0.033925, + 0.009586 + ], + [ + 0.165309, + 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"Oxy decile", + "LOW", + "Adobe Connect link", + "http://kitgroup.adobeconnect.com/r78kx3s6igal", + "Adobe Connect dial-in", + "(866)311-3125", + "Adobe Connect conference code", + "3229477117", + "Source: https://www.industrydocuments.ucsf.edu/docs/fkhb0235", + "MNKOI 0000320356" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004221.json b/doc_00004221.json new file mode 100644 index 0000000000000000000000000000000000000000..83d059952e2544af23db2c32ccfd8cc2bded1d09 --- /dev/null +++ b/doc_00004221.json @@ -0,0 +1,846 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.144777, + 0.1101, + 0.201127, + 0.052966 + ], + [ + 0.701882, + 0.100426, + 0.124385, + 0.040316 + ], + [ + 0.196831, + 0.187931, + 0.048476, + 0.026603 + ], + [ + 0.259554, + 0.178799, + 0.543733, + 0.052258 + ], + [ + 0.111076, + 0.210424, + 0.68302, + 0.066864 + ], + [ + 0.132624, + 0.255029, + 0.066774, + 0.037129 + ], + [ + 0.192617, + 0.278399, + 0.38921, + 0.056535 + ], + [ + 0.106441, + 0.347286, + 0.00546, 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Also BUT nous", + "still on guide as to fresence of a", + "reaction", + "(.) brasil's results on unaged lages are", + "are looking \"critique-aly at both bits", + "not quite same as BEW's - - UZ", + "of work", + "4 Now have a good solid base-line", + "for contrasting Brasil data vs BEW l.e try to show", + "a", + "all tobaccos behave", + "Confirming if yr2 is the same ( 1 + Brasel", + "similarly", + "b", + "tobaccos behave similarly yearby", + "year)", + "Source: https://www.industrydocuments.ucsf.edu/docs/ffwb0197" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004222.json b/doc_00004222.json new file mode 100644 index 0000000000000000000000000000000000000000..c096a2008fa246c2d7d2aabf7e9baf0bba31c510 --- /dev/null +++ b/doc_00004222.json @@ -0,0 +1,4272 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.178163, + 0.096606, + 0.190375, + 0.01108 + ], + [ + 0.178401, + 0.155947, + 0.200635, + 0.014065 + ], + [ + 0.179668, + 0.165519, + 0.294974, + 0.04099 + ], + [ + 0.181958, + 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The following dates are based upon existing", + "Poster/Retail for Dave Edmund Tour/Spring", + "Source: https://www.industrydocuments.ucsf.edu/docs/jxgp0024", + "January 11, 1990", + "January 12, 1990", + "February 9, 1990", + "February 8, 1990", + "February 12, 1990", + "March 12, 1990", + "March 15, 1990", + "March 19, 1990", + "April 9, 1990", + "March 29, 1990", + "April 2, 1990", + "April 30, 1990", + "January 8, 1990", + "February 1, 1990", + "March 5, 1990", + "February 8, 1990", + "February 12, 1990", + "March 12, 1990", + "Chin", + "INTER-OFFICE CORRESPONDENCE", + "120 PARK AVENUE, NEW YORK, NY 10017", + "DATE: December 8, 1989" + ] + }, + { + "bbox": [ + [ + 0.180181, + 0.095619, + 0.310233, + 0.013978 + ], + [ + 0.180364, + 0.126268, + 0.089286, + 0.014135 + ], + [ + 0.180511, + 0.140923, + 0.145203, + 0.011688 + ], + [ + 0.181435, + 0.155205, + 0.133207, + 0.012007 + ], + [ + 0.182216, + 0.184506, + 0.178315, + 0.013705 + ], + [ + 0.181553, + 0.214078, + 0.089509, + 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Such a process should promote the take-up of", + "ideas, concepts and scientific results to the benefit of participants. We are keenly aware that the", + "success of this project will inevitably be measured in the short term by its contribution to the", + "enhancement of the performance of the contributing companies, though we suspect that there will", + "be also long term ideas that will bear fruit during the next decade.", + "It is, of course, impossible to adequately convey the substance of the last two reports (November", + "1995 and May 1996) which have appeared since our last Newsletter. Suffice to say that they", + "contain some 500 pages of detailed scientific reports. If there are issues which prompt your", + "special interest from this Newsletter, then do not hesitate to contact your company", + "representative(s) to gain more information or contact ourselves directly.", + "In contrast this Newsletter contains a series of concise, readily digestible articles and summaries:", + "-", + "the views of two company scientists about the value and management of LINK", + "programmes.", + "-", + "some intriguing results relating to water activity behaviour in multiphase products.", + "-", + "a brief outline of some of the interesting experimental results which were prepared for", + "a", + "short, concentrated course on \"The Application of the Glassy State Concept to the", + "Control of Sugar Crystallization\".", + "a", + "wider perspective on techniques and approaches to the study of flavour sorption and", + "release which will complement the detailed studies of Miranda Hau.", + "an extract from BBSRC Business reporting on the potential of some of the", + "microbiological work with which the ACTIF II programme has been associated,", + "specifically through the additional support provided by the EU Human Capital Mobility", + "Postdoctoral Fellowship", + "an extract from the MAFF Food Link News which reports the award of the Loncin Prize", + "of $50,000 as a recognition of the research performed under the aegis of the ACTIF I and", + "ACTIF II programmes which have been supported by your company.", + "Faculty of Agricultural and Food Sciences, Department of Applied Biochemistry and Food Science", + "Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD", + "Telepbone (0115)951 6140 Facamile (0115)951 6142", + "AQ12464" + ] + }, + { + "bbox": [ + [ + 0.186103, + 0.132401, + 0.499665, + 0.012794 + ], + [ + 0.18561, + 0.146647, + 0.049827, + 0.011597 + ], + [ + 0.185737, + 0.159949, + 0.573527, + 0.012535 + ], + [ + 0.185686, + 0.173908, + 0.573102, + 0.012467 + ], + [ + 0.185406, + 0.18757, + 0.573358, + 0.012467 + ], + [ + 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They have been greatly appreciated because", + "they tell a story briefly! They are listed below:", + "1.", + "The effect of sucrose on the extrusion of maize grits: Starch conversion.", + "2.", + "Stress relaxation as an index of macromolecular network development during", + "retrogradation of extruded waxy maize starch.", + "3.", + "Water, a selective plasticizer in biopolymer-sugar systems.", + "4.", + "Impact of processing on molecular mobility in starch-water systems.", + "5.", + "Physical evolution of starch-glycerol-water systems.", + "6.", + "Volatile interaction with starch; an equilibrium headspace study.", + "7.", + "Bacterial survival during the production of rubbery gelatin.", + "8.", + "Quorum sensing.", + "9.", + "Maillard browning: Does the matrix matter?", + "10.", + "Molecular basis of enzyme activity in biopolymer gels. A 19F NMR study.", + "11.", + "Measuring rotational correlation coefficients of fluorinated lysozyme.", + "12.", + "Diffusion of N-Fluoroacetyl-Glucosamine in gelatin gels.", + "13.", + "Mechanical determination of textures Part 1 of 2: Developing a method.", + "14.", + "Mechanical determination of textures Part 2 of 2: An example application.", + "15.", + "Mechanical determination of textures: A brief explanation.", + "16.", + "The crystallization of sugars.", + "Professor J M V Blanshard", + "Director", + "Faculty of Agricultural and Food Sciences, Department of Applied Biochemistry and Food Science", + "Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD", + "Telephone (0115)951 6140 Facsimile (0115)951 6142", + "AQ12464" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004225.json b/doc_00004225.json new file mode 100644 index 0000000000000000000000000000000000000000..24ba4c3e4ccde1e92074f9d33f64d4946fa4ac9c --- /dev/null +++ b/doc_00004225.json @@ -0,0 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Date: December 20, 1972", + "Re: Senate Ident. # S807", + "2.", + "Name of Committee: Tobacco People's Public Affairs Committee", + "3. Change: Question 4 (a)", + "State and", + "Ful 1 Names of Candidates", + "Mailing Address", + "Congressional", + "Party", + "District", + "Vance Hartke", + "Volunteers for Hartke", + "Indiana -", + "Senate Office Building", + "Senate", + "Dem.", + "Washington, D. C. 20510", + "County of Restunt of Columbir", + "State of cigaringto", + "1, JoHn F Muss", + ", being duly sworn, depose (affirm) and say that the in-", + "formation in this Amended Registration Form and Statement is complete, true, and correct.", + "Shylanner", + "Signature of Treasurer, of Political Committee)", + "Subscribed and sworn to (affirmed) before me this 51 day of the A.D. 1972", + "My commission expires Jes ii 30", + ", 1976", + "(Notary/Public)", + "TI4669-0480", + "Source: https://wwwindustrydocuments.ucsf.edu/docs/fmcn0045" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004228.json b/doc_00004228.json new file mode 100644 index 0000000000000000000000000000000000000000..1584ea83fd4d8126e8bbb62e4e66445fec1c1f9e --- /dev/null +++ b/doc_00004228.json @@ -0,0 +1,1054 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.463925, + 0.130928, + 0.090277, + 0.011302 + ], + [ + 0.265548, + 0.170323, + 0.495706, + 0.011924 + ], + [ + 0.407944, + 0.223621, + 0.21035, + 0.01306 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chemically defined flavoring substances:", + "411 known flavoring substances, including those on the F.E.M.A. GRAS and", + "F.D.A. GRAS and food additives lists, those in the Council of Europe", + "publacetion, those proposed for the E.C. Inventories and those resulting", + "ircm industry recearch should be put through the Priority Setting", + "****", + "renedure. The result will be that each substance is assigned", + "rising from 1 to 7.", + "All those in the jouest priority rankings 3, 2, and 1 should be give.", + "a", + "FERMISSIBLE\" status, which for the U.S.A. would be equivalent", + "tisA tempor any GRAS status. Those substances could then be used under the", + "conditions based on which their priority renking bed been determined.", + "011 substances in the higher priority rankings 7, 6, 5, and 4 would have", + "to be evsluated for safety in descending", + "their", + "ranking,", + "by", + "panel:", + "of experts, such as the F.E.M.A. Expert Panol, the Experts of the Council", + "of Europe, of the E.C. Scientific Committee on Food, and the J.E.C.F.A..", + "Sarety evaluations already performed by any of these panels on certain", + "uvoring substances should be fully taken into consideration.", + "The result of such safety evaluations could be expressed as either:", + "Parmitted according to G.M.P.;", + "Permitted under restrictions of quantity or application;", + "or Not Permitted.", + "Flavorings composed of flavoring substances temporarily or otherwise", + "permitted should then be ecceptable for use in foods in the countries of", + "the E.C., the Council of Europe, the U.S.A., and in any other country", + "agrecing with this procedure." + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004229.json b/doc_00004229.json new file mode 100644 index 0000000000000000000000000000000000000000..4265556fe905efffc70bd220102400a58e372708 --- /dev/null +++ b/doc_00004229.json @@ -0,0 +1,1106 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.584993, + 0.242415, + 0.241926, + 0.021854 + ], + 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SPANO", + "COMMITTEES", + "MEMBER OF ASSEMBLY", + "CITIES", + "872 DISTRICT", + "AGING", + "CITY OF YONKERS", + "LABOR", + "DISTRICT ORFICE:", + "SUB-COMMITTEE", + "ROOM 616, 30 SOUTH BROADWAY", + "ON", + "YONKERS, NEW YORK 10701", + "CITY RE-DEVELOPMENT", + "(914) 969-5104", + "ALBANY OFFICE:", + "919 LEGISLATIVE OFFICE BUILDING", + "ALBANY, NEW YORK 12248", + "472-8500", + "March 21, 1980", + "Virginia K. Landry", + "28 Birch Brook Rd.", + "Bronxville, N.Y. 10708", + "Dear Mrs. Landry.:", + "Thank you for your letter of February 26, 1980, expressing your views on", + "the proposed \"Clean Indoor Air Act\".", + "I fully understand your position on this legislation. Be assuredi that I", + "will oppose it when it comes to the Assembly floor for action.", + "Thank you again for writing and if I may be of further assistance, please", + "don't hesibate to contact me.", + "Sincerely,", + "Ruth Spend", + "NICHOLAS A. SPANO:", + "Member of Assembly", + "City ofi Yonkers", + "NAS:lfs", + "Source: https://www.industrydocuments.ucsf.edu/docs/kygd0122" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004230.json b/doc_00004230.json new file mode 100644 index 0000000000000000000000000000000000000000..ea33c1685ab7ec6a78c6b776f6db9bde06156099 --- /dev/null +++ b/doc_00004230.json @@ -0,0 +1,872 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.589321, + 0.03285, + 0.311662, + 0.008534 + ], + [ + 0.572288, + 0.042977, + 0.34442, + 0.011295 + ], + [ + 0.252241, + 0.114922, + 0.480288, + 0.01211 + ], + [ + 0.435921, + 0.132351, + 0.099293, + 0.006371 + ], + [ + 0.61085, + 0.139994, + 0.225831, + 0.028289 + ], + [ + 0.534276, + 0.239482, + 0.15465, + 0.013314 + ], + [ + 0.201937, + 0.294418, + 0.166946, + 0.010985 + ], + [ + 0.415921, + 0.322106, + 0.224295, + 0.010201 + ], + [ + 0.46437, + 0.336169, + 0.261453, + 0.01258 + ], + [ + 0.201528, + 0.362926, + 0.125153, + 0.01045 + ], + [ + 0.201374, + 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C. I. McCARTY", + "Re: SIR WALTER RALEIGH", + "Competitive Ad Expenditures", + "Dear Charlie:", + "Here are six (6) copies of the Competitive Advertising Ex-", + "penditures - Smoking Tobacco report for the Third Quarter", + "1970, dated February 1971.", + "As you will note, this reporting is in the enlarged size", + "consistent with your discussion with Tony Hebel.", + "During the 3rd Quarter, Reynold's CARTER HALL reported in-", + "creased expenditures over previous Quarter expenditures,", + "but less than the comparable 1969 quarterly expenditures.", + "Philip Morris FIELD & STREAM also reported increased 3rd", + "Quarter expenditures, with the increase in ad schedulings", + "in Male Outdoor magazines. BORKUM RIFF, PALADIN BLACKCHERRY,", + "and SAIL reported decreased expenditures in this Quarter.", + "Cordially,", + "han Cuham", + "Leonard G. Arkema", + "LGA/ss", + "Encl.", + "ce: Messrs. D. Donninger", + "R. Johnson", + "670945333", + "670945333", + "PRODUCED FROM B&W WEB SITE", + "Source: https://www.industrydocuments.ucsf.edu/docs/htyf0097" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004231.json b/doc_00004231.json new file mode 100644 index 0000000000000000000000000000000000000000..219fabf6c1efb7ca24ca3b8460b304069ea0c67a --- /dev/null +++ b/doc_00004231.json @@ -0,0 +1,404 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.849346, + 0.077284, + 0.033163, + 0.029378 + ], + [ + 0.276302, + 0.29303, + 0.208888, + 0.009972 + ], + [ + 0.276625, + 0.360868, + 0.470996, + 0.009641 + ], + [ + 0.277017, + 0.387448, + 0.517884, + 0.012201 + ], + [ + 0.277127, + 0.401201, + 0.468615, + 0.012111 + ], + [ + 0.277413, + 0.414846, + 0.08993, + 0.009386 + ], + [ + 0.277394, + 0.442221, + 0.503607, + 0.011844 + ], + [ + 0.277123, + 0.455078, + 0.504869, + 0.014238 + ], + [ + 0.277335, + 0.469526, + 0.510183, + 0.012063 + ], + [ + 0.277397, + 0.483, + 0.476371, + 0.011988 + ], + [ + 0.315132, + 0.519187, + 0.121025, + 0.040796 + ], + [ + 0.278725, + 0.592347, + 0.101437, + 0.00962 + ], + [ + 0.278472, + 0.632863, + 0.097252, + 0.009484 + ], + [ + 0.279276, + 0.646497, + 0.130467, + 0.009601 + ], + [ + 0.216374, + 0.981379, + 0.56754, + 0.015754 + ] + ], + "poly": [ + [ + { + "X": 0.849346, + "Y": 0.077284 + }, + { + "X": 0.882509, + "Y": 0.077284 + }, + { + "X": 0.882509, + "Y": 0.106662 + }, + { + "X": 0.849346, + "Y": 0.106662 + } + ], + [ + { + "X": 0.276302, + "Y": 0.29303 + }, + { + "X": 0.48519, + "Y": 0.29303 + }, + { + "X": 0.48519, + "Y": 0.303002 + }, + { + "X": 0.276302, + "Y": 0.303002 + } + ], + [ + { + "X": 0.276625, + "Y": 0.360868 + }, + { + "X": 0.747621, + "Y": 0.360868 + }, + { + "X": 0.747621, + "Y": 0.370509 + }, + { + "X": 0.276625, + "Y": 0.370509 + } + ], + [ + { + "X": 0.277017, + "Y": 0.387448 + }, + { + "X": 0.794901, + "Y": 0.387448 + }, + { + "X": 0.794901, + "Y": 0.399649 + }, + { + "X": 0.277017, + "Y": 0.399649 + } + ], + [ + { + "X": 0.277127, + "Y": 0.401201 + }, + { + "X": 0.745742, + "Y": 0.401201 + }, + { + "X": 0.745742, + "Y": 0.413312 + }, + { + "X": 0.277127, + "Y": 0.413312 + } + ], + [ + { + "X": 0.277413, + "Y": 0.414846 + }, + { + "X": 0.367343, + "Y": 0.414846 + }, + { + "X": 0.367343, + "Y": 0.424232 + }, + { + "X": 0.277413, + "Y": 0.424232 + } + ], + [ + { + "X": 0.277394, + "Y": 0.442221 + }, + { + "X": 0.781001, + "Y": 0.442221 + }, + { + "X": 0.781001, + "Y": 0.454065 + }, + { + "X": 0.277394, + "Y": 0.454065 + } + ], + [ + { + "X": 0.277123, + "Y": 0.455078 + }, + { + "X": 0.781992, + "Y": 0.455078 + }, + { + "X": 0.781992, + "Y": 0.469316 + }, + { + "X": 0.277123, + "Y": 0.469316 + } + ], + [ + { + "X": 0.277335, + "Y": 0.469526 + }, + { + "X": 0.787518, + "Y": 0.469526 + }, + { + "X": 0.787518, + "Y": 0.48159 + }, + { + "X": 0.277335, + "Y": 0.48159 + } + ], + [ + { + "X": 0.277397, + "Y": 0.483 + }, + { + "X": 0.753768, + "Y": 0.483 + }, + { + "X": 0.753768, + "Y": 0.494988 + }, + { + "X": 0.277397, + "Y": 0.494988 + } + ], + [ + { + "X": 0.315132, + "Y": 0.519187 + }, + { + "X": 0.436157, + "Y": 0.519187 + }, + { + "X": 0.436157, + "Y": 0.559983 + }, + { + "X": 0.315132, + "Y": 0.559983 + } + ], + [ + { + "X": 0.278725, + "Y": 0.592347 + }, + { + "X": 0.380162, + "Y": 0.592347 + }, + { + "X": 0.380162, + "Y": 0.601968 + }, + { + "X": 0.278725, + "Y": 0.601968 + } + ], + [ + { + "X": 0.278472, + "Y": 0.632863 + }, + { + "X": 0.375724, + "Y": 0.632863 + }, + { + "X": 0.375724, + "Y": 0.642347 + }, + { + "X": 0.278472, + "Y": 0.642347 + } + ], + [ + { + "X": 0.279276, + "Y": 0.646497 + }, + { + "X": 0.409743, + "Y": 0.646497 + }, + { + "X": 0.409743, + "Y": 0.656097 + }, + { + "X": 0.279276, + "Y": 0.656097 + } + ], + [ + { + "X": 0.216374, + "Y": 0.981379 + }, + { + "X": 0.783914, + "Y": 0.981379 + }, + { + "X": 0.783914, + "Y": 0.997133 + }, + { + "X": 0.216374, + "Y": 0.997133 + } + ] + ], + "score": [ + 0.9391, + 0.9891, + 0.9915, + 0.9923, + 0.999, + 0.9961, + 0.9993, + 0.9922, + 0.9967, + 0.9917, + 0.511, + 0.8498, + 0.9779, + 0.9983, + 0.7723 + ], + "text": [ + "F", + "NOTE TO: MR C PROCTOR", + "TOBACCO STRATEGY GROUP MEETING : 8th DECEMBER 1993", + "As you may be aware, Ray Thornton is preparing a paper on the Scientific Research", + "Group for discussion at the next meeting of the Tobacco Strategy Group on", + "8th December", + "Barry Bramley would like you to attend the TSG meeting with Ray. The meeting", + "starts at 19 00 a.m. and the SRG review is one of the first items on the agenda, so", + "could you please be at Windsor House by that time. As Ray has attended previous", + "meetings, it is best if you liaise with him as to where to go in Windsor House.", + "Gal", + "G J BURGESS", + "GJB/btm/n-657", + "17th November 1993", + "Source: https://www.industrydocuments.ucsf.edu/docs/jmff0027" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004232.json b/doc_00004232.json new file mode 100644 index 0000000000000000000000000000000000000000..9b31df344b91a75667771215c5042a0e8f8d5da7 --- /dev/null +++ b/doc_00004232.json @@ -0,0 +1,736 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.811641, + 0.098548, + 0.058772, + 0.012558 + ], + [ + 0.191334, + 0.127658, + 0.250078, + 0.014279 + ], + [ + 0.099107, + 0.165326, + 0.067819, + 0.011817 + ], + [ + 0.190233, + 0.162083, + 0.21952, + 0.011963 + ], + [ + 0.09899, + 0.189716, + 0.065799, + 0.011725 + ], + [ + 0.190866, + 0.18663, + 0.115665, + 0.014921 + ], + [ + 0.098884, + 0.214091, + 0.0361, + 0.010029 + ], + [ + 0.190536, + 0.211201, + 0.206706, + 0.013739 + ], + [ + 0.223277, 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ESBENSHADE", + "GARTH T. VINCENT", + "355 SOUTH GRAND AVENUE", + "33 NEW MONTGOMERY TOWER", + "PETER R. TAFT", + "TED DANE", + "ROSERT K. JOHMSONT", + "NINETEENTH FLOOR", + "MARK SHINDERMAN", + "FLOOR", + "ALAN v. FRIEDMANT", + "STUART N. SENATOR", + "SAN FRANCISCO, CALIFORNIA 94105-9781", + "RONALD L OLSON*", + "MARTIN D. BERN", + "DENNIS E, KINNAIRD", + "DANIEL P. COLLINS", + "LOS ANGELES, CALIFORNIA 90071-1560", + "TELEPHONE (415) 512-4000", + "RICHARD S. VOLPERT", + "ALLISON B. STEIN", + "FACSIMILE (415) 512-4077", + "DENNIS c. BROWNT", + "MARSHA HYMANSON", + "TELEPHONE (213) 683-9100", + "ROBERT E. DENHAM", + "MONICA WAHL SHAFFER", + "JEFFREY I. WEINBERGER", + "ANDREW J. THÔMAS", + "ROBERT L ADLER", + "ROBERT E DELL, ANGELO", + "FACSIMILE (213) 687-3702", + "FREDERICK B. WARDER, JR.", + "(1932-1972)", + "CARY a. LERMAN", + "BRUCE A. ABBOTT", + "WILLIAM L CATHEY, JR.", + "SUSAN R. SZABO", + "MELVYN H. WALD", + "CHARLES D. SIEGAL", + "BERNARDO SILVA", + "(1947-1992)", + "RONALD K. MEYER", + "KRISTIN S. ESCALANTE", + "E. LERÓY TOLLES", + "GREGORY P. STONE", + "JONATHAN E. ALTMAN", + "(RETIRED)", + "VILMA 5. MARTINEZ", + "GREGG W. KETTLES", + "-", + "BRAD D. DRIAN", + "STEVEN a. WEISBURD", + "BRADLEY 5. PHILLIPS", + "MARY ANN LYMAN", + "GEORGE M. GARVEY", + "CARLA N. JONES", + "RITA J. MILLER", + "JOHN c. ULIN", + "WILLIAM D. TEMKO", + "BURTON A. GROSS", + "WRITER'S DIRECT LINE", + "STEVEN L GUISE!", + "STEVEN W. HAWKINS", + "ROBERT a. KNAUSS", + "DAVID M. ROSENZWEIG", + "R. GREGORY MORGAN", + "DAVID C. DINIELLI", + "STEPHEN M. KRISTOVICH", + "JAMES H. ELLIS", + "EDWARD C. HAGEROTT, JR.", + "TERRY E SANCHEZ", + "pr, 65 LiGht", + "213-683-9255", + "JOHN w. SPIEGEL", + "KEVIN S. MASUDA", + "STEVEN M. PERRY", + "ANDREA J. WEISS", + "stonegp@mto.com", + "RUTH E FISHER", + "PETER A. DETRE", + "MARK a. HELM", + "ELIZADETH EARLE BESKE", + "JOSEPH D. LEE", + "MICHAEL J. O'SULLIVAN", + "MICHAEL R. DOYEN", + "STEVEN H. USDAN", + "MICHAEL E, SOLOFF", + "JENNIFER R. SCULLION", + "GREGORY p. PHILLIPS", + "DEVON ALEXANDER GOLD", + "JOHN B. FRANK", + "JOSE F. SANCHEZ", + "LAWRENCE C. BARTH", + "KELLY M. KLAUS", + "KATHLEEN M. MEDOWELL", + "MICHAEL E. GREANEY", + "GLENN D. POMERANTZ", + "HOJOON HWANG", + "THOMAS B. WALPER", + "SEAN A. MONROE", + "RONALD C. HAUSMANN", + "DOUGLAS A. AXEL", + "PATRICK J. CAFFERTY, JR.", + "RACHEL M. CAPOCCIA", + "JAY M. FUJITANI", + "BRUCE H. SEARBY", + "July 28, 1998", + "O'MALLEY M. MILLER", + "JONATHAN R. LEVEY", + "SANDRA A. SEVILLE-JONES", + "MELINDA J. DEMSKY", + "MARK H. EPSTEIN", + "MELISSA BEARSON DAWSON", + "HENRY WEISSMANN", + "DAVID H. FRY", + "KEVIN S. ALLRED", + "STEPHEN E. MORRISSEY", + "co: C. Will", + "MARC A. BECKER", + "JANICE M. KROLL", + "CYNTHIA L BURCH", + "TAMERUIN J. GONLEY", + "BART H. WILLIAMS", + "TIM CONNORS", + "WEFFREY A. HEINTZ", + "PAMELA D. BARNES", + "JUDITH T. KITANO", + "GAIL. M.L. MOSSE", + "KRISTIN LINSLEY MYLES", + "DAVID B. GOLDMAN", + "MARC T.G. DWORSKY", + "DAVIO S. LAW", + "JEROME c. ROTH", + "DOUGLAS M. FUCHS", + "STEPHEN p. ROSE", + "ASIM BHANSALI", + "JEFFREY L BLEICH", + "JOHN L FLYNN", + "DANA s. TREISTER", + "A PROFESSIONAL CORPORATION", + "Gregory G. Little, Esq.", + "Mark H. Berlind, Esq.", + "Senior Assistant General Counsel", + "Philip Morris Management Corp.", + "Philip Morris Companies Inc.", + "120 Park Avenue", + "120 Park Avenue", + "New York, New York 10017-5592", + "New York, New York 10017-5592", + "Re:", + "The People of the State of California v. Philip Morris Incorporated,", + "et al., Los Angeles Superior Court, Case No. BC 194217", + "Dear Greg and Mark:", + "As you know, my partners, Pat Cafferty and Kristin Myles, will be working on", + "the above-referenced matter with me. Indeed, I think they will be much more actively", + "involved in the day-to-day activities in this case than I will. With that in mind, I thought you", + "might want to know more about each of them, and I therefore enclose copies of their", + "respective professional summaries.", + "Should you have any questions about either of these attorneys or our staffing for", + "this case, please do not hesitate to raise them with me. In addition, we do anticipate adding at", + "E", + "C", + "E", + "E", + "[480990.1]", + ":", + "1", + "IUL 3 1 1998", + "MARK H. BER!", + "t", + "7", + "Source: https://www.industrydocuments.ucsf.edu/docs/gsdb0013" + ] + }, + { + "bbox": [ + [ + 0.081037, + 0.107222, + 0.282133, + 0.010105 + ], + [ + 0.126646, + 0.156833, + 0.179919, + 0.014736 + ], + [ + 0.126329, + 0.173188, + 0.173169, + 0.014652 + ], + [ + 0.125627, + 0.1897, + 0.10607, + 0.014296 + ], + [ + 0.126384, + 0.20627, + 0.051727, + 0.014015 + ], + [ + 0.126521, + 0.269484, + 0.721745, + 0.014986 + ], + [ + 0.126232, + 0.286329, + 0.643317, + 0.014602 + ], + [ + 0.459521, + 0.320146, + 0.076069, + 0.014065 + ], + [ + 0.460798, + 0.369489, + 0.133048, + 0.013911 + ], + [ + 0.126119, + 0.416121, + 0.055395, + 0.011649 + ], + [ + 0.12542, + 0.432687, + 0.083077, + 0.01169 + ], + [ + 0.12738, + 0.881161, + 0.063054, + 0.008061 + ], + [ + 0.217044, + 0.981357, + 0.571086, + 0.016338 + ] + ], + "poly": [ + [ + { + "X": 0.081037, + "Y": 0.107222 + }, + { + "X": 0.36317, + "Y": 0.107222 + }, + { + "X": 0.36317, + "Y": 0.117327 + }, + { + "X": 0.081037, + "Y": 0.117327 + } + ], + [ + { + "X": 0.126646, + "Y": 0.156833 + }, + { + "X": 0.306565, + "Y": 0.156833 + }, + { + "X": 0.306565, + "Y": 0.171569 + }, + { + "X": 0.126646, + "Y": 0.171569 + } + ], + [ + { + "X": 0.126329, + "Y": 0.173188 + }, + { + "X": 0.299499, + "Y": 0.173188 + }, + { + "X": 0.299499, + "Y": 0.18784 + }, + { + "X": 0.126329, + "Y": 0.18784 + } + ], + [ + { + "X": 0.125627, + "Y": 0.1897 + }, + { + "X": 0.231697, + "Y": 0.1897 + }, + { + "X": 0.231697, + "Y": 0.203996 + }, + { + "X": 0.125627, + "Y": 0.203996 + } + ], + [ + { + "X": 0.126384, + "Y": 0.20627 + }, + { + "X": 0.178111, + "Y": 0.20627 + }, + { + "X": 0.178111, + "Y": 0.220284 + }, + { + "X": 0.126384, + "Y": 0.220284 + } + ], + [ + { + "X": 0.126521, + "Y": 0.269484 + }, + { + "X": 0.848266, + "Y": 0.269484 + }, + { + "X": 0.848266, + "Y": 0.28447 + }, + { + "X": 0.126521, + "Y": 0.28447 + } + ], + [ + { + "X": 0.126232, + "Y": 0.286329 + }, + { + "X": 0.769549, + "Y": 0.286329 + }, + { + "X": 0.769549, + "Y": 0.300931 + }, + { + "X": 0.126232, + "Y": 0.300931 + } + ], + [ + { + "X": 0.459521, + "Y": 0.320146 + }, + { + "X": 0.535591, + "Y": 0.320146 + }, + { + "X": 0.535591, + "Y": 0.334212 + }, + { + "X": 0.459521, + "Y": 0.334212 + } + ], + [ + { + "X": 0.460798, + "Y": 0.369489 + }, + { + "X": 0.593846, + "Y": 0.369489 + }, + { + "X": 0.593846, + "Y": 0.3834 + }, + { + "X": 0.460798, + "Y": 0.3834 + } + ], + [ + { + "X": 0.126119, + "Y": 0.416121 + }, + { + "X": 0.181514, + "Y": 0.416121 + }, + { + "X": 0.181514, + "Y": 0.42777 + }, + { + "X": 0.126119, + "Y": 0.42777 + } + ], + [ + { + "X": 0.12542, + "Y": 0.432687 + }, + { + "X": 0.208497, + "Y": 0.432687 + }, + { + "X": 0.208497, + "Y": 0.444378 + }, + { + "X": 0.12542, + "Y": 0.444378 + } + ], + [ + { + "X": 0.12738, + "Y": 0.881161 + }, + { + "X": 0.190434, + "Y": 0.881161 + }, + { + "X": 0.190434, + "Y": 0.889223 + }, + { + "X": 0.12738, + "Y": 0.889223 + } + ], + [ + { + "X": 0.217044, + "Y": 0.981357 + }, + { + "X": 0.78813, + "Y": 0.981357 + }, + { + "X": 0.78813, + "Y": 0.997695 + }, + { + "X": 0.217044, + "Y": 0.997695 + } + ] + ], + "score": [ + 0.9314, + 0.9933, + 0.9943, + 0.9955, + 0.9951, + 0.9989, + 0.9978, + 0.9953, + 0.8602, + 0.9932, + 0.9951, + 0.4787, + 0.813 + ], + "text": [ + "MUNGER, TOLLES & OLSON LLP", + "Gregory G. Little, Esq.", + "Mark H. Berlind, Esq.", + "July 28, 1998", + "Page 2", + "least one younger lawyer to the team, although we have not identified for certain who that will", + "be. As soon as we do, I will share with you information about that attorney as well.", + "Sincerely,", + "Gregory P. Stone", + "GPS:sn", + "Enclosures", + "[480990.1]", + "Source: https://www.industrydocuments.ucsf.edu/docs/gsdb0013" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004234.json b/doc_00004234.json new file mode 100644 index 0000000000000000000000000000000000000000..752ee3403cb089c9bc497a33f5c603bf98582b57 --- /dev/null +++ b/doc_00004234.json @@ -0,0 +1,950 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.385106, + 0.06142, + 0.240075, + 0.022328 + ], + [ + 0.324331, + 0.130429, + 0.220016, + 0.017736 + ], + [ + 0.110397, + 0.197679, + 0.04839, + 0.013496 + ], + [ + 0.436483, + 0.197802, + 0.11943, + 0.014497 + ], + [ + 0.82736, + 0.19709, + 0.073933, + 0.013083 + ], + [ + 0.181626, + 0.226155, + 0.219482, + 0.014027 + ], + [ + 0.181882, + 0.254541, + 0.335168, + 0.017436 + ], + [ + 0.182753, + 0.282865, + 0.448465, + 0.017617 + ], + [ + 0.182504, + 0.310181, + 0.604613, + 0.018412 + ], + [ + 0.182385, + 0.338348, + 0.530891, + 0.017965 + ], + [ + 0.841683, + 0.338269, + 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Cippollone Slip 2.)Jobs and Economic Impact by", + "Tobacco in US. Lists CA. info esp. 3.) Gary Huber article from", + "Consumer Research.", + "Renee Winters Sent docs on Office smoke. Need to send number", + "for Smoking or Health", + "Send article on Sondham to Matthew Oritz", + "Thank you letter to Anne at Dunn and Bradstreet", + "Thank you to Telesec", + "Thank you to Christopher", + "LeAnn Zimmermann 1.Survey by Fight Attend.on Smoke Free Intl", + "flights see if in files under faa #26264 or 26566 and ask Marty or", + "Dianne Avedon. 2. Americans for Non-Smokers rights. Had a", + "Smokefree Airline Packet. Do we have?", + "TI54721364", + "Source: :https://www.industrydocuments.ucsf.edu/docs/ksgw0043" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004235.json b/doc_00004235.json new file mode 100644 index 0000000000000000000000000000000000000000..f63ff294a21cdd5eaf086b6c3871d9ea4586b8ba --- /dev/null +++ b/doc_00004235.json @@ -0,0 +1,1236 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.143628, + 0.079278, + 0.416252, + 0.084191 + ], + [ + 0.144932, + 0.331369, + 0.091595, + 0.012818 + ], + [ + 0.144819, + 0.361676, + 0.027637, + 0.010721 + ], + [ + 0.145451, + 0.391259, + 0.072868, + 0.011584 + ], + [ + 0.260098, + 0.391507, + 0.231802, + 0.011404 + ], + [ + 0.146072, + 0.42103, + 0.048326, + 0.011066 + ], + [ + 0.260218, + 0.421108, + 0.114375, + 0.011111 + ], + [ + 0.432213, + 0.42123, + 0.07508, + 0.011402 + ], + [ + 0.261071, + 0.435934, + 0.086171, + 0.010792 + ], + [ + 0.432564, + 0.435992, + 0.104076, + 0.0111 + ], + [ + 0.260129, + 0.361627, + 0.362029, + 0.011077 + ], 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}, + { + "X": 0.710415, + "Y": 0.924418 + }, + { + "X": 0.672707, + "Y": 0.924418 + } + ], + [ + { + "X": 0.67321, + "Y": 0.934843 + }, + { + "X": 0.815905, + "Y": 0.934843 + }, + { + "X": 0.815905, + "Y": 0.957211 + }, + { + "X": 0.67321, + "Y": 0.957211 + } + ] + ], + "score": [ + 0.4373, + 0.9855, + 0.9973, + 0.994, + 0.9708, + 0.9982, + 0.9982, + 0.9972, + 0.9972, + 0.9971, + 0.9882, + 0.9873, + 0.9797, + 0.9926, + 0.993, + 0.9943, + 0.9874, + 0.9956, + 0.9963, + 0.998, + 0.9904, + 0.9957, + 0.9919, + 0.966, + 0.9847, + 0.6639, + 0.9981, + 0.9986, + 0.9979, + 0.9906, + 0.56, + 0.9977, + 0.9949, + 0.9962, + 0.9957, + 0.9951, + 0.9847, + 0.9923, + 0.8895, + 0.9947, + 0.5912, + 0.9789, + 0.9973, + 0.9983, + 0.9987, + 0.9971, + 0.9937 + ], + "text": [ + "RJ Reynolds", + "June 23, 1997", + "TO:", + "SUBJECT:", + "E-Z Mart - Chain I.D. #0582-00-00", + "COPY:", + "David Gesmundo", + "Mark Cook", + "Stan Driskell", + "Bubba Kirkland", + "Dallas ROU/Houston ROU/Denver ROU/St. Louis ROU", + "Ladies and Gentlemen:", + "The E-Z Mart June accrual promotion was rectified during the past week. Beginning the weck of June 16th, E-Z", + "Mart began a discounting program in all stores on Winston, Camel, and Salem. The pricing on Winston and", + "Camel will be identical to Marlboro (packs and cartons); and Salem, in some stores, will be discounted an", + "additional 10 cents, depending on competition. This promotion is supported by a force-out the week of June 23rd", + "and July 20th. This product will not be marked. All payments will be made by me at the chain headquarters. Due", + "to the delay in launching this program, it will continue through August 15, 1997.", + "You will find attached an authorization to place banners where city ordinances permit. Also, dump bins are", + "permitted except in the Ft. Worth market. Banners will have to be placed on a division level since my allocation is", + "depleted, and I do not know which city ordinances will permit us to place them. Most E-Z Mart supervisors have", + "received dump bins; but if they have not received them, please place one for them.", + "In addition, Doral will remain discounted and should match the current Basic promoted price.", + "If you have any questions, please voice mail me at your carliest convenience.", + "Sincerely,", + "James Murphy", + "JAMES MURPHY", + "Account Manager", + "Attachment", + "JM/js", + "Source:", + "Tobacco Company", + "JAMES D. MURPHY", + "ACCOUNT MANAGER", + "231 Norcross", + "Bossier City, LA 71111", + "Phone: (318) 746-0112", + "Fax: (318) 746-3117", + "V.M. (800) 757-8255 Ext. #67788", + "DATE: 7/1/97", + "6923 04,20,22,23,21,26-29", + "DIV #", + "6924", + "6925", + "6937", + "6939", + "OTHER MSH" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004236.json b/doc_00004236.json new file mode 100644 index 0000000000000000000000000000000000000000..98c7a42b645e88dfb57d6065155e8eb6a77114b9 --- /dev/null +++ b/doc_00004236.json @@ -0,0 +1,794 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.134768, + 0.136568, + 0.144414, + 0.015591 + ], + [ + 0.429017, + 0.115699, + 0.120661, + 0.062129 + ], + [ + 0.134614, + 0.174331, + 0.153446, + 0.01421 + ], + [ + 0.13413, + 0.197486, + 0.219106, + 0.015912 + ], + [ + 0.484928, + 0.19963, + 0.020659, + 0.013229 + ], + [ + 0.519357, + 0.199553, + 0.046383, + 0.014878 + ], + [ + 0.247952, + 0.212229, + 0.06833, + 0.011587 + ], + [ + 0.136326, + 0.245191, + 0.627161, + 0.024596 + ], + [ + 0.171284, + 0.259313, + 0.531082, + 0.020747 + ], + [ + 0.135452, + 0.287518, + 0.01685, + 0.010811 + ], + [ + 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BASKET WILL HAVE 1/41 CIRCULAR FLANGE FOR YOU TO SEAL AGAINST", + "WHEN LOADING TOBACCO. 00 APPROX. 241', ID (=) 23 1/211,", + "2.", + "WILL SEND BASKET DETAIL DRAWINGS. HAVE JUST RECEIVED THEM", + "FROM VENDOR.", + "3. SENDING 02 MONITER INFO.", + "4. CENTERLINE EXPANDER SKID 5907 MM S A1A2. CENTERLINE BURNER", + "EXHAUST 6088 MM S FROM A1A2 (991 MM S FROM CENTERLINE EXPANDER),", + "889 MM WEST FROM C1C2.", + "5. REFERENCE DONE 10/5/79 DWG. NORTH IS TOP OF PAGE.", + "FEED AIRLOCK", + "FROM A1A2 4335 MM SOUTH OR 1397 MM (41-711) S FROM NORTH", + "EDGE OF SKID.", + "FROM C1C2 584 MM EAST OR 559 MM (11-1011) IN FROM EAST EDGE.", + "ELEVATION 1270 MM (41-211) FROM FLOOR.", + "PRODUCT AIRLOCK", + "FROM A1A2 4665 MM SOUTH OR 1727 MM (51-811) S FROM NORTH EDGE.", + "FROM C1C2 635 MM EAST OR 508 MM (1)-811) IN FROM EAST EDGE.", + "ELEVATION 2819 MM (9'-3'1) FROM FLOOR.", + "RECARDS,", + "JACKIE", + "477269 BATROD G", + "ABOVE SENT VIA ITT 11/07/79 0959 EST FROM CRYO PLANT MH" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004237.json b/doc_00004237.json new file mode 100644 index 0000000000000000000000000000000000000000..12d5a3b37aa5e58e93b0a790c97877728660366a --- /dev/null +++ b/doc_00004237.json @@ -0,0 +1,690 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.166916, + 0.134735, + 0.242292, + 0.013184 + ], + [ + 0.734164, + 0.132075, + 0.066855, + 0.013958 + ], + [ + 0.167255, + 0.177151, + 0.145742, + 0.013383 + ], + 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D. Chumney, Jr.", + "3/5/91", + "D. K. Shipley", + "In-Laboratory Cigarette Panel L91-29: - BOBFF-10 (Test) versus", + "BDBPF- (Control) - Both From SIR 91-5 Panel", + "An in-Laboratory smoke panel test was conducted, using coded", + "cigarettes, to compare the smoke agpeal of the above products.", + "Panelists were asked for preference and comments. Results were:", + "Preference", + "Test", + "3", + "Control", + "a", + "No Choice", + "3", + "Comments", + "Panelists' comments indicated that the Control cigarette was a", + "smoother smoke with better draw characteristics. Only one panelist", + "commented on the slight difference in appearance of the two", + "cigarettes. The difference was due to the use of slightly", + "different tipping papers.", + "aw", + "CC: RSS/JFA", + "JEM", + "JGE", + "Source: https://www.industrydocuments.ucsf.edu/docs/flfg0005" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004238.json b/doc_00004238.json new file mode 100644 index 0000000000000000000000000000000000000000..aaea7120722fe2a44a97486fe3bc656b5fe6f440 --- /dev/null +++ b/doc_00004238.json @@ -0,0 +1,1974 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.404488, + 0.078898, + 0.309596, + 0.012366 + ], + [ + 0.185857, + 0.218181, + 0.681341, + 0.016929 + ], + [ + 0.185303, + 0.232298, + 0.657725, + 0.016437 + ], + [ + 0.185627, + 0.245431, + 0.70161, + 0.016021 + ], + [ + 0.185566, + 0.260192, + 0.724036, + 0.014562 + ], + [ + 0.186465, + 0.274054, + 0.723505, + 0.015352 + ], + [ + 0.185597, + 0.288217, + 0.702614, + 0.016096 + ], + [ + 0.1864, + 0.301957, + 0.690846, + 0.015444 + ], + [ + 0.185757, + 0.316423, + 0.70226, + 0.015874 + ], + [ + 0.185615, + 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uning federal facilities deserve the healthiest", + "environment possible. The haalth riska of amoking and exposure", + "to smoke are clearly documented by reports of the Surgeon General", + "of the United States. The evidence indicated that: making da a", + "preventable cause of disease; exposure to environmental tobacco", + "smoke is a cause of discase, including lung cancer, in healthy", + "nonsmokers; and the simple separation of smokers and nonsmokers", + "within the come air space may reduce, but does not ellminate, the", + "exposure of nunsmokers to onvironmental tobacco smoke.", + "Accordingly, by the authority vested in - ao President by the", + "constitution and lave of the United States of America, including", + "Section 7902 (c) of Title S of the United States Code and ouch", + "other lavs, statutes and regulations as are appropriate and", + "applicable, it is hereby ordered as foliows:", + "section 1. policy It is the policy of the Federal Government to", + "establish a snoxe-free environment in all work apaca occupied by", + "Federal employees. The snoking of tobacco products is thus", + "prohibited in all such rederal Government controlled space,", + "including space obtained on a use permit, nominal rental or rent-", + "free basis.", + "section 3. Applicability and Scope of Order. (a) All agencies", + "of the Executive Branch are directed to take all appropriate", + "mcasures to carry out the purpose of this order. All elements", + "of", + "the Legislative and Judicial Branches of the Government are", + "encouraged to mcet the spirit and intent of this Order. The term", + "\"agency\" as used in this Order macans an Executive Department, as", + "defined in 5 U.S.C. 101, or any employing unit or authority of", + "the Federal Government, other than those of the Legislative and", + "Judicial Branches.", + "(b) The tern *employees\" as used in this Order does not include", + "members of the uniformed services. Hovever, nothing in this", + "Executive Order shall ba construed to restrict the Department of", + "Defense from applying restrictions on smoking to the uniformed", + "services.", + "section 3. Responulbilities. The heads of agencies of the", + "Executive Branch are responsible and accountable for implementing", + "the provisions of this Order. The Souretary of Health and Human", + "Services shall provide leaderchip and guidance to the heads of", + "TI0175-1687", + "Source: :ttps://www.industrydocuments.ucsf.edu/docs/klgf0034" + ] + }, + { + "bbox": [ + [ + 0.191651, + 0.08084, + 0.694113, + 0.015257 + ], + [ + 0.190699, + 0.093928, + 0.673159, + 0.014821 + ], + [ + 0.190733, + 0.10626, + 0.695737, + 0.016158 + ], + [ + 0.191063, + 0.120585, + 0.695142, + 0.015978 + ], + [ + 0.213271, + 0.134219, + 0.5077, + 0.015618 + ], + [ + 0.19257, + 0.161917, + 0.660647, + 0.017253 + ], + [ + 0.192235, + 0.176303, + 0.684059, + 0.014539 + ], + [ + 0.192116, + 0.189892, + 0.640733, + 0.016438 + ], + [ + 0.19032, + 0.204004, + 0.587746, + 0.014269 + ], + [ + 0.192023, + 0.217787, + 0.683272, + 0.015674 + ], + [ + 0.190307, + 0.231754, + 0.67423, + 0.014875 + ], + [ + 0.192804, + 0.245255, + 0.67094, + 0.015161 + ], + [ + 0.190846, + 0.259191, + 0.339281, + 0.016171 + ], + [ + 0.191462, + 0.286738, + 0.671826, + 0.015245 + ], + [ + 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then in establishing programs", + "purauant to this Order and shall cooperate and consuit with the", + "heads of agencies in the Legislative and Judicial Branches of the", + "Government to encourage and help them adopt programs resulting in", + "sncke-free vork environment for their employees.", + "Section 4. Implementation. Implementation of the policy of a", + "smoke-free environment shall be achieved in all Ixecutive Branch", + "facilities no later than (six monthe after insuanca) of this", + "order. This vill allow a fixed but reasonable time for", + "transition including, but not limited to. conducting educational", + "programs for remployees about the requirements of this Order and", + "emsisting employees in breaking the snoking habit to the extent", + "permitted by lav and regulation.", + "Section S. Other Powers and Duties. (a) The provisione hereof", + "shall be implenented in a manner consistent with the Federal", + "Service Labor-Management Relations Statute, 5 U.S.C. 7101 et sea,", + "and the National Labor Relations Act, 29 U.S.C. 151 et seg., as", + "applicable. Nothing herein shall be construed to impair or alter", + "the povers and duties of the various Toderal agencies pursuant to", + "responsibilities established under lau, statute or regulation,", + "although all agencies shall construe their authorizing statutes", + "to the maximum extent permitted by lav, in a manner which", + "promotes the specific objectives and general goals of this order.", + "(b) The Secretary of Defense shall be responsible for", + "implementation of all provisions of this Order insofar as they", + "apply to personnel of the Department of Defense.", + "Section 6. Causos of Action. Nothing in this order shall be", + "construed to creata a now oause of action against the United", + "States or to alter in any vay the liability of tha United States", + "under the Federal Tort claims Act.", + "TI0175-1688", + "Source: https://www.industrydocuments.ucsf.edu/docs/klgf0034" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004239.json b/doc_00004239.json new file mode 100644 index 0000000000000000000000000000000000000000..0cd3fa0277aa8b1aaf5884ec6759074f1165142d --- /dev/null +++ b/doc_00004239.json @@ -0,0 +1,794 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.079187, + 0.113574, + 0.01148, + 0.006414 + ], + [ + 0.212612, + 0.069017, + 0.583131, + 0.022023 + ], + [ + 0.264516, + 0.090882, + 0.480831, + 0.015932 + ], + [ + 0.215738, + 0.134301, + 0.165215, + 0.014725 + ], + [ + 0.214904, + 0.148426, + 0.203692, + 0.014766 + ], + [ + 0.216639, + 0.162764, + 0.10833, + 0.01194 + ], + [ + 0.731116, + 0.185653, + 0.021489, + 0.007357 + ], + [ + 0.213913, + 0.254567, 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MILLBANK. LONDON. S.W.1.", + "D. N. HUGHES, ESQ.,", + "R. & D. ESTABLISHMENT,", + "SOUTHAMPTON.", + "Date", + "Dear Mr. Hughes,", + "R. & D.E. Reports Nos. E.15-R", + "and L.36-F.", + "I enclose herewith Requisition Forms Nos. 270", + "and 271 in respect of the above reports and will be pleased", + "to receive the publications in due course.", + "With kind regards,", + "Yours sincerely,", + "ch", + "&", + "?se, by-", + "73", + "Encls:", + "File", + ":", + "Source: https://www.industrydocuments.ucsf.edu/docs/jndg0192", + "From", + "L. W. J. 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SOME OF THE", + "STORE OWNERS GET", + "THEM FROM A GUY IN", + "MAIMI. THIS HAPPENS", + "EVERYTIME HE GETS", + "3.85 FOR ONE", + "CAMEL", + "DOES NOT KNOW", + "DOES NOT KNOW", + "US TAX EXCEMPT", + "CIGS. SENDING CPNS", + "WITH TAX", + "was upset for the purchase of", + "export product. and wanted to", + "on the corner of clark and sawyer rd.. in", + "consumer wanted to knw why the", + "know the why he was selling", + "2.89$or 2.69$for", + "CAMEL", + "pedro stop", + "sarasota fl 34232", + "retailer was selling export product..", + "them", + "the pack", + "Sending her hi dollar cpns as", + "Did not notice until she got home", + "she wanted us to exchange", + "Tobacco Shop (Did not", + "that they were f/export. Upset as", + "them out for her as she was", + "About $3.00", + "actually know name of", + "she save \"W's from packs f/future", + "on vacation when she", + "cheaper per", + "WINSTON", + "store).", + "Elizabethtown, KY.", + "promo's.", + "purchased them.", + "carton.", + "CONSUMER RECEIVED A", + "CONSUMER NOTICED THE US", + "CTN OF CIGS THAT HAD", + "TAX EXEMPT STICKER ON TOP", + "US TAX EXEMPT", + "WINSTON", + "NONE", + "NONE", + "OF PKS", + "STICKERS ON THE TOP", + "$18.99", + "8", + "6929", + "Source: https://www.industrydocuments.ucsf.edu/docs/gpbc0190" + ] + }, + { + "bbox": [ + [ + 0.451781, + 0.057679, + 0.100175, + 0.014478 + ], + [ + 0.457954, + 0.078728, + 0.086619, + 0.016425 + ], + [ + 0.073466, + 0.114274, + 0.055175, + 0.011599 + ], + [ + 0.388548, + 0.113985, + 0.032969, + 0.011327 + ], + [ + 0.074096, + 0.130697, + 0.017568, + 0.013019 + ], + [ + 0.139146, + 0.132802, + 0.041113, + 0.013421 + ], + [ + 0.191524, + 0.13306, + 0.173137, + 0.012975 + ], + [ + 0.38864, + 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lights with a brown", + "filter. mostly Arab owned stores. US Tax", + "$3.50-", + "Exempt. said there are stores flooded in", + "$3.60 per", + "Minneapolis with export cigs", + "pack", + "CON PURCHASED 2 CARTONS OF SALEM IN", + "CANADA SAYS THEY TASTE NOTHING LIKE", + "SALEMS CON WANTED TO KNOW WHY", + "TOLD HER CIGS WHERE EXPORT WHICH", + "CON PURCAHSED 2 CARTONS OF SALEM", + "ARE MANUFACTURED DIFFERENT CAN'T", + "FROM CANADA SAYS THEY TASTE NOTHING APPEASE FOR THIS SITUATION BUT ! WILL", + "LIKE SALEM.", + "SEND CPNS CON SAID THAT EAS FINE.", + "SMOKE SHOP N/A", + "dID NOT REMEMBER PRICE BUT DID SAY", + "YOU WOULD THINK AT LEAST THEY WOULD", + "BE CHEAPER. SENDING CPNS AS", + "APEASEMENT - SAID THIS HAS ALSO", + "Tasted nasty!!!", + "HAPP'ED W/CAMELS & TO HER MOTHER.", + "rou circle m service station arsenal st retailer is", + "says camel cigts say us tax exempt not for sale in selling export camel non filter cigts for 4.00 per", + "4.00 per", + "pk per alice lynch look in to this", + "service station !arsenal st", + "pk", + "us", + "Source: ittps://www.industrydocuments.ucsf.edu/docs/gpbc0190", + "10" + ] + }, + { + "bbox": [ + [ + 0.448476, + 0.058216, + 0.101016, + 0.014673 + ], + [ + 0.454512, + 0.079486, + 0.087243, + 0.016719 + ], + [ + 0.071685, + 0.114747, + 0.054992, + 0.01171 + ], + [ + 0.390877, + 0.114738, + 0.033178, + 0.011149 + ], + [ + 0.07244, + 0.131496, + 0.01714, + 0.012877 + ], + [ + 0.13061, + 0.13372, + 0.041812, + 0.013645 + ], + [ + 0.183076, + 0.133906, + 0.045305, + 0.01287 + ], + [ + 0.235682, + 0.134054, + 0.055639, + 0.012697 + ], + [ + 0.315959, + 0.133871, + 0.056966, + 0.012914 + ], + [ + 0.390891, + 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:", + "Distribution", + "WRITTEN BY:", + "Andrew Schwartz", + "SUBJECT:", + "Consumer Promotion", + "BACKGROUND", + "Couponing and special deals continue to play an increasing part in competitive", + "marketing programs. Reynolds' recent announcement that it will continue to divert", + "advertising dollars into promotional funds, as well as PM's plan to spend more on", + "consumer promotions, especially direct marketing, underline the need to understand the", + "extent to which customers are taking advantage of these incentives. The critical", + "issue continues to be are these specials supported by consumers already in the fold", + "or are they attracting competitive smokers?", + "A series of questions was asked in our 1986 Fall Tracking study in an attempt to", + "measure issues cited above. Of particular interest is a large scale effort by", + "Reynolds involving various six coupon booklets that have been distributed through the", + "mail since the summer of 1985.", + "OVERVIEW", + "The proportion of cigarette smokers who used a coupon in the past three months has", + "increased steadily over time from 21% in the spring '85 to 26% that Fall and 29% in", + "the spring of '86. Current data indicate no change from spring '86 to fall '86.", + "Importantly, the percent who are heavy coupon users has followed the same trend while", + "light coupon usage has remained fairly constant.", + "Past three month usage of 2 for 1 deals indicates a somewhat constant percentage of", + "consumer interest, between 21% and 24% in recent studies.", + "Past 3 Month Usage", + "Spring 85", + "Fall 85", + "Spring 86", + "Fall r 86", + "Coupons At All", + "21%", + "26%", + "29%", + "28%", + "1-2 Times", + "12", + "12", + "13", + "13", + "3+ Times", + "9", + "14", + "16", + "15", + "2 for 1's", + "22", + "24", + "22", + "21", + "For the last year and a half, respondents have also been queried on the receipt of", + "a six-coupon booklet (RJR) and its subsequent use. In each survey period, about a", + "quarter of the smokers contacted had received the booklet.", + "Responses to the question of what they did with them were split almost evenly at", + "one-third each:", + "Fall I 85 Spring I 86 Fall '86", + "Received Coupon Booklet", + "22%", + "29%", + "22%", + "Used to buy couponed brand", + "9", + "10", + "6", + "Did not use", + "8", + "10", + "8", + "Gave away", + "10", + "10", + "8", + "FILE:", + "Consumer Promotion", + "Source: https://www.industrydocuments.ucst.edu/docs/jsbw0124" + ] + }, + { + "bbox": [ + [ + 0.073301, + 0.16154, + 0.803192, + 0.01778 + ], + [ + 0.347519, + 0.210447, + 0.049449, + 0.011531 + ], + [ + 0.348059, + 0.223183, + 0.105756, + 0.015647 + ], + [ + 0.347649, + 0.240582, + 0.048713, + 0.011899 + ], + [ + 0.348729, + 0.254511, + 0.253822, + 0.014961 + ], + [ + 0.348233, + 0.268635, + 0.243579, + 0.016425 + ], + [ + 0.34877, + 0.285979, + 0.165305, + 0.013763 + ], + [ + 0.348886, + 0.300588, + 0.175352, + 0.014809 + ], + [ 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seen previously, coupon users, vis-a-vis - - total smokers, are more likely", + "Women", + "Older (35+)", + "White", + "Nielsen B county residents", + "Heavy consumers (21+/day)", + "Carton purchasers", + "Supermarket buyers", + "Reynolds smokers", + "Non-PM smokers", + "Data collected on heaviness of coupon use have been examined with no major", + "differences between heavy users (3+ occasions) and users in general.", + "Purchased 2 for l's", + "Compared to total smokers, 2-for-1 users skew:", + "Younger (<35)", + "Less affluent", + "Pack buyers", + "The profile of 2-for-1 purchasers is very different from that of coupon users;", + "higher proportions of 2-for-1 purchasers are:", + "Men", + "Younger (<35)", + "Black", + "Less affluent", + "Light smokers (<20/day)", + "Pack buyers", + "Convenience store purchasers", + "6 Coupon Booklet", + "The Reynold's booklet distribution continues to mirror smoker brand shares and", + "demographics, indicating a blanket rather than targeted approach.", + "With almost one-quarter of smokers receiving the six-coupon booklet and a majority", + "either using it or giving it away, it is not surprising that the profile of coupon", + "users closely resembles that of receivers/redeemers of the booklet. The following", + "differences are noted when compared to total smokers;", + "FINDINGS", + "Coupon Users", + "to be:", + "Pack purchasers were less likely to have remembered receiving the booklet or", + "redeeming the coupons therein. It appears that the monetary incentive of", + "Source: https://www.industrydocuments.ucsf.edu/docs/jsbw0124" + ] + }, + { + "bbox": [ + [ + 0.075497, + 0.104091, + 0.803445, + 0.016273 + ], + [ + 0.076042, + 0.122181, + 0.075634, + 0.011648 + ], + [ + 0.124401, + 0.150337, + 0.685678, + 0.01677 + ], + [ + 0.124668, + 0.166234, + 0.733396, + 0.016839 + ], + [ + 0.125681, + 0.180519, + 0.338186, + 0.016122 + ], + [ + 0.644385, + 0.212762, + 0.077758, + 0.012498 + ], + [ + 0.506835, + 0.228262, + 0.077048, + 0.012169 + ], + [ + 0.642912, + 0.2265, + 0.08713, + 0.016856 + ], + [ + 0.37844, + 0.244121, + 0.046864, + 0.012184 + ], + [ + 0.508115, + 0.243571, + 0.076021, + 0.015241 + ], + [ + 0.674283, + 0.244398, + 0.017743, + 0.011591 + ], + [ + 0.212481, + 0.259245, + 0.107675, + 0.015052 + ], + [ + 0.378792, + 0.259643, + 0.067807, + 0.012093 + ], + [ + 0.506705, + 0.259364, + 0.068583, + 0.012132 + ], + [ + 0.653114, + 0.259322, + 0.06911, + 0.012389 + ], + [ + 0.212422, + 0.289299, + 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This may also reflect their", + "purchasing habits in that light smokers buy packs, heavy smokers -- cartons.", + "Those redeeming booklet coupon (s) are more likely than receivers of the booklet to", + "have been:", + "Older", + "White", + "Carton buyers", + "Heavier smokers", + "Supermarket purchasers", + "Reynolds smokers", + "Receipt of the six-coupon booklet approximates smoker share for most brands.", + "Exceptions are noted below for key brands (>2% share) :", + "Index (Receipt/Smoker Share)", + "Camel", + "74", + "Newport", + "87", + "Marlboro", + "86", + "Vantage", + "139", + "Smokers of the following key brands exhibited the highest receipt to redemption", + "indices:", + "Camel", + "116", + "Salem", + "168", + "Vantage", + "189", + "Winston", + "190", + "Source: https://www.industrydocuments.ucsf.edu/docs/jsbw0124" + ] + }, + { + "bbox": [ + [ + 0.074417, + 0.113721, + 0.73174, + 0.015637 + ], + [ + 0.298681, + 0.162136, + 0.068488, + 0.014585 + ], + [ + 0.465669, + 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In total, 58% of coupon booklet", + "redeemers were Reynolds' own smokers.", + "Almost half (45%) of RJR's smokers have used money-off coupons in the three", + "months preceding the study; 33% for their regular brand.", + "RJR has the highest proportion of its following as heavy (3+) coupon users", + "(27%), more than triple that of P.M. (8%).", + "24% of Reynolds smokers have redeemed 3 or more coupons for their regular", + "brand, a proportion five-fold that of P.M. (5%). This finding supports our", + "strategy for targeted coupon efforts.", + "Coupon \"Pass-Along\"", + "In an effort to better understand the dynamics of coupon sharing, we asked smokers", + "in the fall study ('86):", + "-", + "Has anyone given you one or more coupons for cigarettes (past 3 months) ?", + "-", + "Who gave you these coupons?", + "-", + "Have you given any cigarette coupons to other people?", + "15% of smokers report receiving coupons from other people in the past three", + "months. Neighbors and friends were mentioned most frequently as the source of", + "these coupons.", + "Coupon \"Pass Along\"", + "Neighbor/friend", + "38%", + "Immediate family", + "23", + "Other relative", + "13", + "Co-worker", + "10", + "Merchant", + "9", + "Coupon club", + "1", + "Other", + "3", + "Source: https://www.industrydocuments.ucsf.edu/docs/jsbw0124" + ] + }, + { + "bbox": [ + [ + 0.072879, + 0.101027, + 0.74388, + 0.016528 + ], + [ + 0.074219, + 0.116496, + 0.7927, + 0.015709 + ], + [ + 0.07402, + 0.131559, + 0.753208, + 0.016603 + ], + [ + 0.075927, + 0.147935, + 0.366757, + 0.01464 + ], + [ + 0.123353, + 0.177597, + 0.741454, + 0.016381 + ], + [ + 0.123384, + 0.194778, + 0.074006, + 0.01173 + ], + [ + 0.122844, + 0.221741, + 0.741627, + 0.017515 + ], + [ + 0.622429, + 0.269427, + 0.244583, + 0.014456 + ], + [ + 0.611525, + 0.284483, + 0.057894, + 0.012546 + ], + [ + 0.808891, + 0.284766, + 0.019414, + 0.011409 + ], + [ + 0.425653, + 0.284778, + 0.126661, + 0.012358 + ], + [ + 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These promotion conscious consumers are", + "receiving pass-along coupons disproportionately from others. This appears to", + "increase with heaviness of coupon use:", + "38% of coupon users received coupons from others compared to 15% among total", + "smokers.", + "47% of coupons passed to others were to heavier cigarette coupon users (3+).", + "Past 3 Month Coupon Usage", + "At All", + "3+", + "Total Smokers", + "1-2", + "3367", + "22,000", + "2838", + "6205", + "N =", + "47%", + "15%", + "26%", + "38%", + "Received Pass-Along Coupons", + "17% of smokers reported that they had in the past three months given cigarette", + "coupons to other people. Not surprisingly, smokers of Reynolds brands received a", + "disproportionate number of coupons from other people (56%). Perhaps those coupons", + "\"given away\" are passed to people with an expressed interest in coupons (lower", + "brand loyalty) or a current user of the brand.", + "Price/Value-Smokers", + "As a percent of franchise, the price value category has the highest rate of coupon", + "usage. This is most likely a function of the heavy promotion of the category.", + "Used Coupon For", + "Used Coupons", + "Other Than Own Brand", + "Past 3 Months", + "At All", + "At All", + "1-2X", + "3+", + "1-2X", + "3+", + "6%", + "3%", + "8%", + "15%", + "13%", + "28%", + "Total Smokers", + "7", + "10", + "35", + "17", + "11", + "47", + "Total Price Value", + "6", + "11", + "17", + "69", + "12", + "82", + "Cambridge", + "14", + "3", + "10", + "42", + "11", + "Doral", + "53", + "14", + "27", + "13", + "62", + "14", + "76", + "Century", + "*", + "46", + "*", + "*", + "16", + "Players Lts.", + "63", + "*", + "*", + "*", + "48", + "14", + "62", + "Richland", + "6", + "16", + "9", + "12", + "11", + "23", + "Store Brands/Generics", + "Source: https://www.industrydocuments.ucsf.edu/docs/jsbw0124" + ] + }, + { + "bbox": [ + [ + 0.074156, + 0.10128, + 0.782967, + 0.015744 + ], + [ + 0.07468, + 0.116572, + 0.792953, + 0.016218 + ], + [ + 0.074873, + 0.133361, + 0.171995, + 0.013143 + ], + [ + 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Possible factors contributing to lower", + "coupon usage by this group might include:", + "Full price brands with coupons are still more expensive than regular store", + "brands.", + "Store brands are rarely promoted.", + "Retail positioning in a separate \"savings in black and white aisle\" may", + "discourage comparison.", + "Consumer perception that generics are a lower cost alternative to branded", + "generic entries.", + "generics.", + "Retail pricing - positioning generics as a lower cost alternative to branded", + "Source: https://www.industrydocuments.ucsf.edu/docs/jsbw0124" + ] + }, + { + "bbox": [ + [ + 0.0737, + 0.109213, + 0.116474, + 0.012145 + ], + [ + 0.073004, + 0.124451, + 0.078703, + 0.012649 + ], + [ + 0.072619, + 0.139633, + 0.117906, + 0.014594 + ], + [ + 0.073995, + 0.154988, + 0.068524, + 0.013008 + ], + [ + 0.073373, + 0.170599, + 0.097611, + 0.01284 + ], + [ + 0.073403, + 0.18552, + 0.127137, + 0.01345 + ], + [ + 0.073835, + 0.201364, + 0.087329, + 0.01266 + ], 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Alter", + "A. Bissmeyer", + "I. Bick", + "N. Brennan", + "V. Buccellato", + "R. Camisa", + "W. I. Campbell", + "D. Dangoor", + "E. Fortner", + "H. Foster", + "H. Goldfrach", + "J. Isaacs", + "C. Kohl", + "E. LaBauve", + "C. Leiber", + "C. Levy", + "D. Mackey", + "E. Merlo", + "K. Miller", + "J. Raporte", + "R. Roper", + "B. Schuyler", + "J. Scully", + "R. Simons", + "J. Spector", + "R. Stirlen", + "L. Suwarna", + "D. Tso", + "L. Wexler", + "J. 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Was that for a brand other than your", + "regular brand?", + "Table 13", + "Source: https://www.industrydocuments.ucsf.edu/docs/jsbw0124" + ] + }, + { + "bbox": [ + [ + 0.136055, + 0.491994, + 0.094218, + 0.01549 + ], + [ + 0.13484, + 0.507826, + 0.096463, + 0.014621 + ], + [ + 0.134947, + 0.522649, + 0.096708, + 0.01306 + ], + [ + 0.105264, + 0.55365, + 0.049202, + 0.013018 + ], + [ + 0.135671, + 0.569536, + 0.03532, + 0.014298 + ], + [ + 0.136682, + 0.584511, + 0.046673, + 0.01233 + ], + [ + 0.134897, + 0.599855, + 0.066858, + 0.01255 + ], + [ + 0.135804, + 0.615235, + 0.103469, + 0.012491 + ], + [ + 0.105987, + 0.645589, + 0.069201, + 0.014043 + ], + [ + 0.136523, + 0.660262, + 0.034936, + 0.014001 + ], + [ + 0.13744, + 0.674779, + 0.045417, + 0.012734 + ], + [ + 0.125907, + 0.720854, + 0.096642, + 0.012754 + ], + [ + 0.106386, + 0.766944, + 0.046865, + 0.012676 + ], + [ + 0.204198, + 0.78244, + 0.25401, + 0.0153 + ], + [ + 0.203993, + 0.797097, + 0.135831, + 0.014838 + ], + [ + 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Was that for a brand other than your", + "Source: https://www.industrydocuments.ucsf.edu/docs/jsbw0124", + "Coupon Usage", + "Brand", + "Used Coupon For", + "Other Than Own Brand", + "Used Coupons", + "3+", + "At All", + "1-2X", + "At All", + "1-2X", + "3+", + "3%", + "8%", + "6%", + "28%", + "13%", + "15%", + "3", + "3", + "6", + "24", + "41", + "18", + "2", + "4", + "6", + "10", + "16", + "6", + "*", + "*", + "*", + "9", + "*", + "*", + "7", + "2", + "5", + "26", + "45", + "18", + "1", + "5", + "4", + "16", + "25", + "41", + "3", + "5", + "8", + "27", + "20", + "48", + "6", + "16", + "9", + "12", + "11", + "23", + "2", + "4", + "6", + "9", + "20", + "29", + "2", + "6", + "9", + "30", + "20", + "51", + "*", + "*", + "*", + "29", + "20", + "49", + "*", + "*", + "*", + "32", + "24", + "57", + "4", + "6", + "10", + "7", + "10", + "18", + "7", + "4", + "11", + "9", + "12", + "21", + "3", + "5", + "8", + "6", + "8", + "14", + "3", + "6", + "9", + "24", + "19", + "43", + "4", + "2", + "6", 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"inser.", + "PALLADIUM TIMES", + "Sched. NO-CHARGE makegood", + "W/O 4/26/81", + "DAILY REPUBLTC", + "Sched. 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SW1H ONL", + "Facsimile Cover Sheet", + "To: HENRY TAYLOR", + "C/O FOO AH CHOY", + "Company:", + "SINGAPORE TOBACCO CO.", + "Phone:", + "Facsimile Number: 010 657586938", + "From: MELISSA BOWMAN", + "Phone: 071 222 7979", + "Facsimile Number: 071 233 1792", + "Date: 19/10/92", + "Pages including this cover :", + "2", + "Comments:", + "DEAR MR CHOY.", + "COULD YOU PLEASE PASS THE FOLLOWING MESSAGE ON TO HENRY TAYLOR,", + "WHEN YOU SEE HUM NEXT?", + "MANY THANKS", + "MELISSA BOWMAN", + "SECRETARY TO HENRY TAYLOR" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004246.json b/doc_00004246.json new file mode 100644 index 0000000000000000000000000000000000000000..fc2bcd1e438680043f0fe5c4d4b5e35446474c5b --- /dev/null +++ b/doc_00004246.json @@ -0,0 +1,534 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.135368, + 0.110977, + 0.152359, + 0.013288 + ], + [ + 0.717886, + 0.111227, + 0.135351, + 0.015285 + ], + [ + 0.134567, + 0.177197, + 0.034312, + 0.012842 + ], + [ + 0.245306, + 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Box 920", + "Frederick, MD 21705", + "Claims that have been sent to the Horsham, PA office will be forwarded to our new benefits", + "office in Frederick, MD. I have been told that this will delay the payment of claims by only", + "one day. In addition, if you have any questions for the benefits office, the new phone", + "number is 1-800-685-4030.", + "New plastic ID cards and claim forms will be sent to all employees soon.", + "- - Alison Duly -", + "Tl11560959", + "Source: https://www.industrydocuments.ucsf.edu/docs/hpnm0043" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004247.json b/doc_00004247.json new file mode 100644 index 0000000000000000000000000000000000000000..072850ad39a4aa331f13e012907173c46891de58 --- /dev/null +++ b/doc_00004247.json @@ -0,0 +1,2052 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.399043, + 0.062698, + 0.492744, + 0.016912 + ], + [ + 0.394674, + 0.08825, + 0.169748, + 0.014326 + ], + [ + 0.729663, + 0.086739, + 0.157976, + 0.013359 + ], + [ + 0.308165, + 0.106316, + 0.039904, + 0.009597 + ], + [ + 0.394488, + 0.103812, + 0.129572, + 0.011601 + ], + [ + 0.75866, + 0.103089, + 0.128764, + 0.011168 + ], + [ + 0.136208, + 0.189329, + 0.368311, + 0.014714 + ], + [ + 0.136341, + 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Dunn, Technical Consulting Director", + "Advertising Research Foundation", + "212-751-5656", + "FOR IMMEDIATE RELEASE", + "NEW YORK, February 18, 1993 - The Advertising Research Foundation (ARF) today released", + "a detailed independent methodological evaluation of a study reported in the June 1992 issue", + "of Annals of Internal Medicine entitled \"Pharmaceutical Advertisements in Leading Medical", + "Journals: Experts' Assessments.*", + "The ARF evaluation found that \"the many faults inherent in the study design, execution and", + "analysis leads to an inability to accept\" the study's conclusion that many pharmaceutical", + "advertisements contain deficiencies in areas in which the FDA has established explicit standards", + "of quality. Moreover, the authors' implication that practicing physicians will therefore be led by", + "pharmaceutical advertising to incorrectly prescribe is not addressed by the study, nor is it", + "supported by additional research cited by the authors and reviewed by ARF.", + "The evaluation was undertaken by ARF at the request of the Association of National Advertisers", + "(ANA) and the American Association of Advertising Agencies (AAAA), which asked the", + "independent research organization to \"examine the appropriateness of the design, methodology", + "and execution of the study to support its stated findings.\" ARF agreed on the condition, as is", + "its practice, that it would publish its complete findings whatever the result.", + "The evaluation's principal author, Dr. Theodore F. Dunn, ARF Technical Consulting Director,", + "said the evaluation was based not only on the published article itself but also on other", + "published documents to which the study referred as well as on additional but incomplete", + "material which ARF was able to obtain through the Freedom of Information Act.", + "He said the objective of the study reported on in the article was \"to assess both the accuracy", + "of scientific data presented in pharmaceutical advertisements and the compliance of these", + "advertisements with current Food and Drug Administration (FDA) standards.\" A panel of 113", + "physicians and 52 pharmacists was used for the study, each of whom reviewed from one to", + "three ads in selected medical journais and completed a self-administered questionnaire for each", + "ad. Based on these data, the article's authors concluded that \"in the opinion of the reviewers,", + "many advertisements contained deficiencies in areas in which the FDA has established explicit", + "standards of quality.\"", + "Such a conclusion is scientifically unacceptable, said Dr. Dunn, because of the many faults in", + "study design, execution and analysis. Perhaps the most serious flaw, he said, is the fact that", + "Source: https://www.industrydocuments.ucsf.edu/docs/gqbv0044" + ] + }, + { + "bbox": [ + [ + 0.500942, + 0.078788, + 0.011312, + 0.011308 + ], + [ + 0.1433, + 0.109143, + 0.724467, + 0.014851 + ], + [ + 0.143396, + 0.124271, + 0.724898, + 0.015993 + ], + [ + 0.142339, + 0.141467, + 0.725162, + 0.014986 + ], + [ + 0.142875, + 0.157917, + 0.72479, + 0.015479 + ], + [ + 0.142464, + 0.174857, + 0.264846, + 0.012121 + ], + [ + 0.14185, + 0.206462, + 0.724829, + 0.015718 + ], + [ + 0.142817, + 0.223174, + 0.725374, + 0.015053 + ], + [ + 0.142415, + 0.239041, + 0.725147, + 0.015004 + ], + [ + 0.142366, + 0.254658, + 0.72491, + 0.014923 + ], + [ + 0.141362, + 0.270913, + 0.725432, + 0.014823 + ], + [ + 0.141781, + 0.28718, + 0.725956, + 0.01526 + ], + [ + 0.142384, + 0.304352, + 0.725374, + 0.014862 + ], + [ + 0.141543, + 0.320733, + 0.063517, + 0.011563 + ], + [ + 0.142343, + 0.352389, + 0.726224, + 0.015411 + ], + [ + 0.142189, + 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0.9986, + 0.9992, + 0.9806, + 0.9931, + 0.9983, + 0.9873, + 0.9781, + 0.9971, + 0.7725 + ], + "text": [ + "2", + "all of the reviewers were experienced medical journal article reviewers. This suggests that they", + "brought to their task a predisposition to apply the same standards to the advertisements that", + "they would normally apply to refereed or \"peer review\" journal articles. In fact, he said, the", + "study design suggests that they may well have been encouraged to evaluate the", + "advertisements in such a manner.", + "Among other notable faults in the study design, according to the ARF evaluation, were (1)", + "reviewers were made aware of the purposes of the study, thus creating a critical and negative", + "predisposition toward the ads; (2) the medical journals used were not selected on a random", + "basis; (3) the reviewers themselves were not selected on a random basis; (4) the reviewers", + "were not trained on FDA standards and guidelines underlying the basis for the study, and (5)", + "instructions to the reviewers were vague and in some instances may actually have directed", + "reviewers away from the prescribing summaries accompanying the ads when they reviewed", + "the ads.", + "More important, however, than the article's questionable conclusion that the ads do not meet", + "FDA standards, said Dr. Dunn, is that its authors then proceed to draw a further implication -", + "-not at all addressed by the study - that practicing physicians will be led by pharmaceutical", + "advertising to incorrectly prescribe. They base this additional implication on other research", + "\"suggesting that drug advertising serves as a major source of information for practicing", + "physicians.\"", + "Of the articles cited by the authors as evidence of this, four were reviewed as part of the ARF", + "evaluation and were found not to support that conclusion. In fact the findings of at least two", + "of the studies suggest that, rather than relying on pharmaceutical advertising as a major source", + "of information about drugs, physicians are actually somewhat skeptical and cautious about", + "this source and regard colleagues and detail persons as more important influences in", + "prescribing.", + "\"While a study could be devised to test the hypothesis that physicians could be led by some", + "advertising to inappropriately prescribe an advertised medication,\" said Dr. Dunn, \"the study", + "reviewed by ARF was not designed for that purpose. As designed, it is totally inappropriate", + "to shed any light on that hypothesis. Yet it has attempted to use its findings, however", + "inadequate, for that purpose.\"", + "The Advertising Research Foundation is an independent, industrywide, non-profit organization", + "which provides independent and impartial research leadership and expertise to advance the", + "science of advertising research. Its members include advertisers, advertising agencies, media,", + "research firms, and educational and governmental organizations.", + "Note to Editors: The full text of the ARF evaluation is an accompaniment to this release.", + "Source: :ttps://www.industrydocuments.ucsf.edu/docs/gqbv0044" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004248.json b/doc_00004248.json new file mode 100644 index 0000000000000000000000000000000000000000..7b1540350c8268386ad2776841a45fa84dc48bdb --- /dev/null +++ b/doc_00004248.json @@ -0,0 +1,3004 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.25133, + 0.068547, + 0.1264, + 0.026276 + ], + [ + 0.278298, + 0.089811, + 0.072257, + 0.009244 + ], + [ + 0.268237, + 0.098711, + 0.089191, + 0.011498 + ], + [ + 0.31697, + 0.09758, + 0.030245, + 0.006394 + ], + [ + 0.277679, + 0.109705, + 0.080981, + 0.012312 + ], + [ + 0.282776, + 0.121149, + 0.069451, + 0.010768 + ], + [ + 0.30402, + 0.133495, + 0.025184, + 0.008244 + ], + [ + 0.26207, + 0.144675, + 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Raley speaks to an Enterprise audience.", + "Raley questions", + "Foshee funding", + "By Michael Smith", + "sald. \"I have a clean bill of", + "Ledger Staff Writer", + "health. We didn't waste a lot of", + "time In the hospital. We were", + "GOP candidate J.T. Raley has", + "politicking while we were there.", + "ilterally climbed out ofa hospital", + "Raley's \"pollicking In Enter-", + "bed to continue a campaign to", + "prise was alined al ethics, or the", + "wrestle the District 31 State", + "lack there of, in government.", + "Senate seat away from Demo-", + "\"This campalgn is about", + "cratic incumbent E.C. \"Crum\"", + "character and Il's about cthics", + "Foshee,", + "in office. Raley sald. \"Il's about", + "Raley spoke in Enterprise", + "ethics in government. We really", + "Wednesday al a meeting of the", + "need some of that in the Ala-", + "Coffee County Republican Wo-", + "bama legislature.", + "men. just six days after under-", + "\"In my military service and'", + "golng surgery in Andalusia to", + "my business career I've faced", + "remove his gall bladder. Raley", + "many tough clecisions. But, I", + "was released from the hospital", + "never found it necessary to com-", + "Sunday.", + "\"Everything is well,\" Ralcy", + "See RALEY, Pago-2", + "RALEY", + "Reynolds and Boeing Aircraft,", + "he said.", + "\"Why should those groups be", + "From Page 1", + "interested in what's going on in", + "Coffee County. or in Covington", + "promise the basic ideas of hon-", + "nor Escambla Counties?\" Raley", + "esty and integrity to get the job", + "asked. \"Whyshould they be put-", + "done.\"", + "ting money in here to influence", + "Raley wasn't as quick to say", + "this election one way or", + "the same about his opponent.", + "another?\"", + "He instead questioned Foshee's", + "only have one special inter-", + "campaign practices and the", + "est group and that's the people", + "source of his campaign", + "of the 31st District, he sald.", + "contributions.", + "\"Something certainly must be", + "\"I don't know how much dif-", + "done about about the co-", + "ference it might have made If the", + "mingling or camouflaging of", + "people in Coffee, Covington and", + "funds so that the people do not", + "Escambla Counties had known", + "know where their candidates", + "that Crum Foshee spent over", + "obtain money.\"", + "$100,000 - over 85 percent of", + "which came from outside his", + "Raley sald he has spent less", + "own district - in his defeat of", + "than $10,000 on the campaign", + "Wesley Laird.\" Raley said. \"Mr.", + "and is relying heavily on fun-", + "Laird spent. 1 believe. less than", + "draisers. Raley said he is ac-", + "$20,000.", + "Uvely soliciting for campaign", + "Raley said Foshee's campaign", + "funds. but only in District 31.", + "contributions included about", + "And. he said. If elected. he", + "$80,000 from special Interest", + "would try to ostrengthen the Eth-", + "groups within the state and", + "Ics Commission in an effort to", + "more than $6,000 from special", + "make government more ac-", + "interest groups outside the", + "countable and responsible.", + "state. Among those were conti-", + "\"One of the bills that want to", + "butions from America Tobacco", + "introduce will be a good ethics", + "institute. Phillip Morris. R.J.", + "bill. Raley said,", + "TI23060112", + "Source: https://www.industrydocuments.u edu/docs/hmbh0032" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004249.json b/doc_00004249.json new file mode 100644 index 0000000000000000000000000000000000000000..8524391b59bfad2de16a68217264cc30445e3ab3 --- /dev/null +++ b/doc_00004249.json @@ -0,0 +1,456 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.106312, + 0.345972, + 0.210233, + 0.012963 + ], + [ + 0.108901, + 0.360835, + 0.139159, + 0.012138 + ], + [ + 0.106876, + 0.375869, + 0.142912, + 0.010576 + ], + [ + 0.10682, + 0.390066, + 0.216748, + 0.01232 + ], + [ + 0.106851, + 0.449108, + 0.328244, + 0.010774 + ], + [ + 0.106197, + 0.478019, + 0.277181, + 0.013838 + ], + [ + 0.232044, + 0.493505, + 0.199023, + 0.013516 + ], + [ + 0.225666, + 0.981039, + 0.547596, + 0.016926 + ], + [ + 0.399655, + 0.057836, + 0.155283, + 0.011468 + ], + [ + 0.412737, + 0.072865, + 0.129825, + 0.01107 + ], + [ + 0.388794, + 0.087955, + 0.177845, + 0.010891 + ], + [ + 0.429431, + 0.117367, + 0.0962, + 0.01037 + ], + [ + 0.506915, + 0.160288, + 0.123829, + 0.013611 + ], + [ + 0.508827, + 0.635079, + 0.163736, + 0.051127 + ], + [ + 0.523983, + 0.716528, + 0.158667, + 0.043588 + ], + [ + 0.598479, + 0.755108, + 0.137977, + 0.094083 + ], + [ + 0.716109, + 0.490972, + 0.06623, + 0.011238 + ] + ], + "poly": [ + [ + { + "X": 0.106312, + "Y": 0.345972 + }, + { + "X": 0.316545, + "Y": 0.345972 + }, + { + "X": 0.316545, + "Y": 0.358935 + }, + { + "X": 0.106312, + "Y": 0.358935 + } + ], + [ + { + "X": 0.108901, + "Y": 0.360835 + }, + { + "X": 0.248059, + "Y": 0.360835 + }, + { + "X": 0.248059, + "Y": 0.372972 + }, + { + "X": 0.108901, + "Y": 0.372972 + } + ], + [ + { + "X": 0.106876, + "Y": 0.375869 + }, + { + "X": 0.249788, + "Y": 0.375869 + }, + { + "X": 0.249788, + "Y": 0.386445 + }, + { + "X": 0.106876, + "Y": 0.386445 + } + ], + [ + { + "X": 0.10682, + "Y": 0.390066 + }, + { + "X": 0.323568, + "Y": 0.390066 + }, + { + "X": 0.323568, + "Y": 0.402386 + }, + { + "X": 0.10682, + "Y": 0.402386 + } + ], + [ + { + "X": 0.106851, + "Y": 0.449108 + }, + { + "X": 0.435096, + "Y": 0.449108 + }, + { + "X": 0.435096, + "Y": 0.459882 + }, + { + "X": 0.106851, + "Y": 0.459882 + } + ], + [ + { + "X": 0.106197, + "Y": 0.478019 + }, + { + "X": 0.383378, + "Y": 0.478019 + }, + { + "X": 0.383378, + "Y": 0.491856 + }, + { + "X": 0.106197, + "Y": 0.491856 + } + ], + [ + { + "X": 0.232044, + "Y": 0.493505 + }, + { + "X": 0.431067, + "Y": 0.493505 + }, + { + "X": 0.431067, + "Y": 0.507021 + }, + { + "X": 0.232044, + "Y": 0.507021 + } + ], + [ + { + "X": 0.225666, + "Y": 0.981039 + }, + { + "X": 0.773262, + "Y": 0.981039 + }, + { + "X": 0.773262, + "Y": 0.997965 + }, + { + "X": 0.225666, + "Y": 0.997965 + } + ], + [ + { + "X": 0.399655, + "Y": 0.057836 + }, + { + "X": 0.554938, + "Y": 0.057836 + }, + { + "X": 0.554938, + "Y": 0.069305 + }, + { + "X": 0.399655, + "Y": 0.069305 + } + ], + [ + { + "X": 0.412737, + "Y": 0.072865 + }, + { + "X": 0.542562, + "Y": 0.072865 + }, + { + "X": 0.542562, + "Y": 0.083936 + }, + { + "X": 0.412737, + "Y": 0.083936 + } + ], + [ + { + "X": 0.388794, + "Y": 0.087955 + }, + { + "X": 0.566639, + "Y": 0.087955 + }, + { + "X": 0.566639, + "Y": 0.098846 + }, + { + "X": 0.388794, + "Y": 0.098846 + } + ], + [ + { + "X": 0.429431, + "Y": 0.117367 + }, + { + "X": 0.52563, + "Y": 0.117367 + }, + { + "X": 0.52563, + "Y": 0.127737 + }, + { + "X": 0.429431, + "Y": 0.127737 + } + ], + [ + { + "X": 0.506915, + "Y": 0.160288 + }, + { + "X": 0.630744, + "Y": 0.160288 + }, + { + "X": 0.630744, + "Y": 0.173899 + }, + { + "X": 0.506915, + "Y": 0.173899 + } + ], + [ + { + "X": 0.508827, + "Y": 0.635079 + }, + { + "X": 0.672563, + "Y": 0.635079 + }, + { + "X": 0.672563, + "Y": 0.686205 + }, + { + "X": 0.508827, + "Y": 0.686205 + } + ], + [ + { + "X": 0.523983, + "Y": 0.716528 + }, + { + "X": 0.682651, + "Y": 0.716528 + }, + { + "X": 0.682651, + "Y": 0.760116 + }, + { + "X": 0.523983, + "Y": 0.760116 + } + ], + [ + { + "X": 0.598479, + "Y": 0.755108 + }, + { + "X": 0.736455, + "Y": 0.755108 + }, + { + "X": 0.736455, + "Y": 0.849191 + }, + { + "X": 0.598479, + "Y": 0.849191 + } + ], + [ + { + "X": 0.716109, + "Y": 0.490972 + }, + { + "X": 0.782339, + "Y": 0.490972 + }, + { + "X": 0.782339, + "Y": 0.50221 + }, + { + "X": 0.716109, + "Y": 0.50221 + } + ] + ], + "score": [ + 0.8963, + 0.9907, + 0.9936, + 0.8924, + 0.9785, + 0.9945, + 0.9957, + 0.8531, + 0.9963, + 0.9955, + 0.951, + 0.9957, + 0.998, + 0.2182, + 0.9437, + 0.9811, + 0.9988 + ], + "text": [ + "Mr. Eerbert Westphalen", + "Lorillard, Inc.", + "One Park Avenue", + "Now Tork, NY 10016-5895", + "FOR PROFESSIONAL SERVICES RENDERED:", + "Validation - SE Surveys #4204", + "Harley Portfolio Test", + "Source: https://www.industrydocuments.ucsf.edu/docs/fffw0121", + "WINIFRED E. 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It is not clear in the document you sent.", + "Thanks,", + "Qiwei", + "Original Message-", + "From: Chhaya, Vaishali [mailto:Vaishali.Chhaya@mdsinc.com]", + "Sent: Thursday, December 01, 2005 2:32 PM", + "To: Qiwei.Liang@pmusa.com", + "Cc: Sagar.Munjal@pmusa.com; Barbara.K.Zedler@pmusa.com; Lonnie.T.Rimmer@pmusa.com; Bums, Eileen;", + "Gao, Shan; Tom Gibbons; Sautter, Maureen", + "Subject: RE: Part B Question", + "Dear Qiwei,", + "Here is the document containing the requested information. Let us know if you have any", + "questions.", + "Best Regards,", + "Vaishali", + "Vaishali Chhaya", + "Biostatistician", + "MDS Pharma Services", + "The Triad, 2200 Renaissance Blvd, Suite 400", + "King of Prussia, PA 19406-2755 USA", + "Email: vaishali.chhaya@mdsinc.com", + "Phone: 610-239-7900 . X 220", + "Fax: 610-275-6246", + "Original Message--", + "From: Qiwei.Liang@pmusa.com [mailto:Qiwei.Liang@pmusa.com]", + "Sent: Thursday, December 01, 2005 1:51 PM", + "To: Chhaya, Vaishali; Qiwei.Liang@pmusa.com", + "1", + "3102984042", + "3102984042", + "Source: https://www.industrydocuments.ucsf.edu/docs/hskx0219" + ] + }, + { + "bbox": [ + [ + 0.247696, + 0.095545, + 0.561113, + 0.011123 + ], + [ + 0.247961, + 0.10792, + 0.342213, + 0.010771 + ], + [ + 0.248128, + 0.120458, + 0.175574, + 0.011104 + ], + [ + 0.248083, + 0.144691, + 0.08237, + 0.010166 + ], + [ + 0.247644, + 0.17029, + 0.596936, + 0.010872 + ], + [ + 0.247295, + 0.182583, + 0.549555, + 0.010702 + ], + [ + 0.247267, + 0.194105, + 0.065263, + 0.008873 + ], + [ + 0.248107, + 0.220228, + 0.293932, + 0.01081 + ], + [ + 0.248254, + 0.246196, + 0.0778, + 0.010575 + ], + [ + 0.248399, + 0.272366, + 0.033082, + 0.00836 + ], + [ + 0.318633, + 0.289295, + 0.105549, + 0.011064 + ], + [ + 0.295651, + 0.301584, + 0.366888, + 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"Dear Vaishali,", + "Thank you for the information We would like to know more Could you send us the histograms so that", + "we have a better idea about the non-normality? In addition, could you also provide us with the", + "variances?", + "Please call me should you need more information.", + "Best regards,", + "Qiwei", + "Original Message-", + "From: Chhaya, Vaishali [mailto:Vaishali.Chhaya@mdsinc.com]", + "Sent: Thursday, December 01, 2005 12:07 PM", + "To: Qiwei.Liang@pmusa.com", + "Cc: Sagar. Munjal (E-mail); Barbara.K.Zedler@pmusa.com; Lonnie.T.Rimmer@pmusa.com;", + "Burns, Eileen; Gao, Shan; Tom Gibbons; Sautter, Maureen", + "Subject: Part B Question", + "Dear Qiwei,", + "After we checked for the normality and equal variance assumptions for the", + "part B biomarkers' data, we have found the following.", + "Biomarker", + "Assumptions Tested", + "Normality", + "Equal Variance", + "Total NNAL (ng/24h)", + "Not Normal", + "Yes", + "Total NNAL (ng/cig)", + "Not Normal", + "No (p=0.0613)", + "3-HPMA", + "Not Normal", + "Yes", + "1-OHP", + "Not Normal", + "Yes", + "MHBMA", + "Not Normal", + "Yes", + "DHBMA", + "Not Normal", + "No (p=0.0883)", + "Cotinine", + "Not Normal", + "Yes", + "4-ABP", + "Not Normal", + "No (p=0.7879)", + "The assumptions were tested using the raw pooled data. Please let us know", + "as to how to proceed further.", + "Thanks and Best Regards,", + "Vaishali", + "Vaishali Chhaya", + "Biostatistician", + "MDS Pharma Services", + "The Triad, 2200 Renaissance Blvd, Suite 400", + "King of Prussia, PA 19406-2755 USA", + "Email: aaishali.chhaya@mdsinc.com", + "Phone: 610-239-7900 x 220", + "Fax: 610-275-6246", + "2", + "3102984043", + "3102984043", + "Source: https://www.industrydocuments.ucsf.edu/docs/hskx0219" + ] + }, + { + "bbox": [ + [ + 0.057993, + 0.962689, + 0.09139, + 0.011187 + ], + [ + 0.295191, + 0.138432, + 0.522237, + 0.012564 + ], + [ + 0.295582, + 0.152636, + 0.522978, + 0.012448 + ], + [ + 0.295405, + 0.166727, + 0.530546, + 0.01225 + ], + [ + 0.295658, + 0.181201, + 0.544181, + 0.012431 + ], + [ + 0.295688, + 0.195163, + 0.517993, + 0.01284 + ], + [ + 0.295564, + 0.209458, + 0.543734, + 0.012505 + ], + [ + 0.295621, + 0.2236, + 0.472214, + 0.012314 + ], + [ + 0.200094, + 0.265993, + 0.627725, + 0.012704 + ], + [ + 0.200146, + 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read or used only by the intended recipient. If you are not", + "intended recipient of the email or any of its attachments, please be advised that you", + "have received this email in error and any use, dissemination, distribution, forwarding,", + "printing or copying of this email or any allached files is strictly prohibited. If you", + "have received this email in error, please immediately purge it and all attachments and", + "notify the sender by reply email or contact the sender at the number listed.", + "This email and any files transmitted with it may contain privileged or confidential information and", + "may be read or used only by the intended recipient. If you are not the intended recipient of the email", + "or any of its attachments, please be advised that you have received this email in error and any use,", + "dissemination, distribution, forwarding, printing or copying of this email or any attached files is", + "strictly prohibited If you have received this email in error, please immediately purge it and all", + "attachments and notify the sender by reply email or contact the sender at the number listed.", + "Source: https://www.industrydocuments.ucsf.edu/docs/hskx0219", + "3", + "3102984044", + "the" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004251.json b/doc_00004251.json new file mode 100644 index 0000000000000000000000000000000000000000..6915aa6fe7c1dd9b397158174ce34ed8c94b6741 --- /dev/null +++ b/doc_00004251.json @@ -0,0 +1,3174 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.339167, + 0.114479, + 0.322672, + 0.015098 + ], + [ + 0.191656, + 0.214802, + 0.04246, + 0.010957 + ], + [ + 0.29242, + 0.212388, + 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additives; and", + "-", + "TMA advising HMG on an ongoing basis, when appropriate,", + "of surplus permitted additives that were considered to be", + "redundable.", + "Brief LWD about drafting a confidentiality agreement that would", + "facilitate the preparation of a compilation of a list of those additives", + "used, based on confidential company data, and presentation of the", + "composite list to the participating companies and TMA only.", + "Provide the draft of a confidentiality agreement to companies for", + "consideration before 1st September.", + "Draft 17.8.95", + "1", + "Source: https://www.industrydocuments.ucsf.edu/docs/glnf0195" + ] + }, + { + "bbox": [ + [ + 0.334467, + 0.119711, + 0.319765, + 0.011372 + ], + [ + 0.187146, + 0.217798, + 0.039698, + 0.010722 + ], + [ + 0.287892, + 0.217586, + 0.292227, + 0.010142 + ], + [ + 0.186976, + 0.259743, + 0.190903, + 0.010503 + ], + [ + 0.186937, + 0.28773, + 0.077022, + 0.012815 + ], + [ + 0.287349, + 0.287277, + 0.509017, + 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usage of new approved", + "additive to DoH at the time of marketing and certify conformance of", + "use of the additive was within the approved 'global limit'.", + "A delay of six months in Gazetting the new additive would still be", + "required prior to publication.", + "Action", + "The approach would need to be framed in the context of a possible", + "voluntary agreement", + "Confidentiality of Submissions", + "Approach", + "The name of the manufacturer should have no bearing on the", + "outcome of the submission.", + "The SCOTH/TAG scientific secretary would know the authors of", + "submissions at the time the manufacturer's employees have", + "preliminary discussions about additive test requirements.", + "Action", + "When submissions are presented to TAG or SCOTH HMG should", + "continue to impose \"commercial - confidential\" restrictions.", + "Draft 17.8.95", + "3", + "Source: https://www.industrydocuments.ucsf.edu/docs/glnf0195" + ] + }, + { + "bbox": [ + [ + 0.325877, + 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"Product Date Coding", + "Domestic MarIboro- (Complete by 12/00)", + "A", + "4", + "N/A", + "N/A", + "Jan-99", + "Oct-97", + "Jan-99", + "Mar-99", + "National", + "All Other Brands (Complete by 12/00)", + "A", + "4", + "N/A", + "N/A", + "Jan-99", + "Oct-97", + "Jan-99", + "Mar-99", + "National/Export", + "Shrink Film Development", + "Domestic (Complete by 12/02)", + "A", + "3", + "N/A", + "Feb-00", + "Feb-00", + "Feb-00", + "Apr-00", + "National", + "Export (Complete by 4/01)", + "A", + "3", + "N/A", + "Feb-00", + "Apr-00", + "Apr-00", + "May-00", + "Japan", + "9987021807", + "PM USA Confidential, P0622", + "Page 2", + "Date Printed: 3/20/00 7:56 AM" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004255.json b/doc_00004255.json new file mode 100644 index 0000000000000000000000000000000000000000..6a159902c6c89766aacd333eb009b4dcd0d9483e --- /dev/null +++ b/doc_00004255.json @@ -0,0 +1,1314 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.97404, + 0.264543, + 0.011382, + 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Merchants will be required", + "Hal Conklin's motion that the ordi=", + "Continued from Page B1", + "time.", + "by the law to move their cigarettes", + "nance committee review the city", + "The county Health Care Services", + "off the counters and Into locked", + "law withoutspecifiedirectionfrom", + "But the store owners in unincor-", + "Department's tobacco education", + "display cases or overhead racks", + "the councll.", + "porated areas will be required to", + "and control office. will be monitor-", + "that employees directly control.", + "Council members said they have", + "redice the sales of cigarettes to", + "ing the merchants to determine if", + "At City Hall, Councilwoman Har-", + "threechoices: either conform theje:", + ":", + "customers under the age of 18 to 20", + "they are in fact reducing purchases", + "riét Miller couldu't get a second on", + "ordinance to the counly's; delete.", + "percent or less by Sept. 30, 1995.", + "by minors; If merchants do not, the", + "her motlon to direct the ardinance", + "the ban on displays entirely, or-", + "Currently, \"sting\" operations", + "supervisors will be advised on Nov.", + "committee to recast the city law in", + "leaveit in and put il into effectright ;", + "conducted by the county have", + "15, 1995, and the han on self-service", + "the exact Image of the county's law.", + "away,", + "Source: https://www.industrydocuments.ucsf.edu/docs/jlmm0129" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004256.json b/doc_00004256.json new file mode 100644 index 0000000000000000000000000000000000000000..b378a6c763be1b8d9434c669ca7e4dde2fb962a9 --- /dev/null +++ b/doc_00004256.json @@ -0,0 +1,690 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.80641, + 0.080542, + 0.053942, + 0.011955 + ], + [ + 0.208396, + 0.109865, + 0.155946, + 0.014587 + ], + [ + 0.121394, + 0.147546, + 0.038832, + 0.009161 + ], + [ + 0.208386, + 0.144409, + 0.106913, + 0.012726 + ], + [ + 0.120969, + 0.171166, + 0.035587, + 0.009385 + 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0.998, + 0.9589 + ], + "text": [ + "Page 1", + "Note for Chaikin, Karen", + "From:", + "Chaikin, Karen", + "Date:", + "Thu, Mar 31, 1994 5:42 PM", + "Subject:", + "RE: It's the Law Kits", + "To:", + "Fisher, Scott", + "Will do. Let him know we hope to ship these week of April 11. kc", + "From: Fisher, Scott on Thu, Mar 31, 1994 5:40 PM", + "Subject: It's the Law Kits", + "To: Chaikin, Karen", + "2023588329", + "Cc: Walls, Tina", + "Karen,", + "Unit Manager Mike King of Indianapolis, IN has received a request from Kroger's for 100", + "of the It's the Law kits. They can be shipped to Mike at the following address and he will", + "forward to Kroger.", + "PM USA", + "1499 Windhorst Way", + "Suite 160", + "Greenwood, IN 46143", + "ATTN: Mike King", + "Source: https://www.industrydocuments.ucsf.edu/docs/jgwn0106" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004257.json b/doc_00004257.json new file mode 100644 index 0000000000000000000000000000000000000000..219225f8b3c77bcf5e5b616d6de7ccbbbdee8501 --- /dev/null +++ b/doc_00004257.json @@ -0,0 +1,24072 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.00259, + 0.953658, + 0.101491, + 0.011072 + ], + [ + 0.0, + 0.969882, + 0.303631, + 0.010929 + ], + [ + 0.194084, + 0.198578, + 0.58231, + 0.011546 + ], + [ + 0.139911, + 0.23334, + 0.329323, + 0.010244 + ], + [ + 0.127199, + 0.244119, + 0.341877, + 0.00998 + ], + [ + 0.127674, + 0.254694, + 0.342244, + 0.010418 + ], + [ + 0.12744, + 0.265853, + 0.342056, + 0.010396 + ], + [ + 0.127448, + 0.276648, + 0.341589, + 0.010333 + ], + [ + 0.126879, 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Lawson, BS; Garret A. FitzGerald, MD", + "Background Free radical-induced oxidative damage is", + "thought to be involved in the pathogenesis of diseases associ-", + "ated with cigarette smoking. We examined the production of", + "8-epi-prostaglandin (PG) F2 a stable product of lipid peroxi-", + "dation in vivo, and its modulation by aspirin and antioxidant", + "vitamins in chronic cigarette smokers.", + "Methods and Results We performed the following studies:", + "(1) a cross-sectional comparison of smokers and control sub-", + "jects, (2) an examination of the dose-response relationship, (3)", + "an exploration of the effect of smoking cessation (3 weeks) and", + "nicotine patch supplementation, (4) the effect of aspirin consump-", + "tion, and (5) the effects of 5 days' dosing with vitamin E (100 and", + "800 U), vitamin C (2 g), and their combination. 8-epi-PGF20", + "excretion (in pmol/mmol, mean+SEM) was 176.5+30.6 in heavy", + "smokers, 92.7=4.8 (P<.05) in moderate smokers, and 54.1+2.7", + "(P<.005) in nonsmokers. Urinary levels fell from 145.5=24.9 to", + "isoprostanes", + "8-epi-PGF2a", + "C", + "igarette smoking exacts a continuing toll on the", + "public health. Deaths caused by cardiovascular", + "disease attributed to cigarette smoking in the", + "United States are estimated at more than 150 000 an-", + "nually. 1,2 Among the mechanisms hypothesized to con-", + "tribute to smoking-induced vascular damage is oxidant", + "injury.3-9 Highly reactive elements in cigarette smoke", + "facilitate DNA adduct formation6.3 and may directly", + "induce platelet activation and vascular dysfunction.89", + "A detailed understanding of oxidant injury in vivo has", + "been precluded by the lack of reliable indexes of this", + "process that are biochemically stable and susceptible to", + "accurate quantification in a noninvasive manner. 10,11", + "Traditionally, the susceptibility of lipoproteins to oxida-", + "tion ex vivo,12 the detection of chemical adducts ex", + "vivo,¹ 13 and reliance on nonspecific or intermediate in-", + "dexes of the process, such as measurement of malondi-", + "aldehyde14 or conjugated dienes,15 have been used in", + "Clinical Trial Design", + "clinical studies.", + "Recently, attention has focused on families of free", + "radical-catalyzed isomers of arachidonic acid, the iso-", + "prostanes (Fig 1), as stable products of lipid peroxida-", + "tion that circulate in human plasma and are excreted in", + "urine. 16,17 Using an estimate of F2 isoprostanes based on", + "Received April 25, 1995; revision received December 28, 1995;", + "accepted January 2, 1996.", + "From the Center for Experimental Therapeutics, University of", + "Pennsylvania, Philadelphia.", + "Presented in part at the annual meeting of the American Society", + "for Clinical Investigation, Washington, DC, May 1994, and at the", + "Ninth International Conference on Prostaglandins and Related", + "Compounds, Florence, Italy, August 1994.", + "Reprint requests to Dr G.A. FitzGerald, Center for Experimental", + "Therapeutics, 905 Stellar Charice Building, University of Pennsylva-", + "nia, Philadelphia, PA 19104. E-mail garret@spirit.gcrc.upenn.edu.", + "C 1996 American Heart Association, Inc.", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqyl0102", + "Modulation of Oxidant Stress In Vivo in", + "Chronic Cigarette Smokers", + "114.6+27.1 (week 2, P<.05) and 112.6+24.9 (week 3, P<.05) on", + "cessation of smoking. Aspirin treatment failed to suppress urinary", + "levels of 8-epi-PGF2m despite a significant reduction in urinary", + "11-dehydro-TxB2 production and suppression of 8-epi-PGF2, and", + "TxB2 in serum. Vitamin C (pre, 194.6=40.9; post, 137.2+34.1;", + "P<.05) and a combination of vitamin C and E (pre, 171.0+39.8;", + "post, 133.5+29.6; p<.05) suppressed urinary 8-epi-PGF2.0", + "whereas vitamin E alone had no effect.", + "Conclusions Urinary 8-epi-PGF20 may represent a noninva-", + "sive, quantitative index of oxidant stress in vivo. Elevated levels", + "of 8-epi-PGF2. in smokers may be modulated by quitting", + "cigarettes and switching to nicotine patches or by antioxidant", + "vitamin therapy. (Circulation. 1996;94:19-25.)", + "free radicals", + "smoking", + "Key Words", + "prostaglandins", + "a PGF20 internal standard, Morrow and colleagues have", + "reported increased levels in cigarette smokers.18 The", + "present study confirms and extends these findings.", + "We have developed a method to measure specifically", + "8-epi-PGF2a, an abundant F2 isoprostane with mitogen-", + "ic19 and vasoconstrictor17 capability. Excretion is dose-", + "dependently increased in apparently healthy chronic", + "cigarette smokers and falls when they switch to nicotine", + "patches. Although 8-epi-PGF20 may be formed in either", + "a free radical- or a COX-dependent manner,20 the", + "increment in smokers in vivo is suppressed by antioxi-", + "dant vitamins but not by aspirin. This contrasts with the", + "smoking-related increment in thromboxane metabolite", + "formation, reflective of platelet activation, which is", + "suppressed by aspirin.", + "Methods", + "The clinical studies were performed at the Center for", + "Cardiovascular Science at the Mater Hospital, a teaching", + "hospital of University College in Dublin, Ireland. Informed", + "consent was obtained from all subjects. Both nonsmoking and", + "smoking volunteers were apparently healthy, with normal", + "physical examination, biochemical screen, and full blood count.", + "They reflected the ethnic catchment area of the hospital; all", + "were white. The smokers ranged in age from 20 to 47 years", + "(median, 27 years). No smokers or control subjects were taking", + "any medications, including vitamins.", + "Five studies were performed. The first, a cross-sectional", + "investigation, involved the collection of spot free-flow urine", + "samples between 9 and 11 AM in 24 chronic cigarette smokers", + "(18 men) who had smoked at least 15 cigarettes per day for the", + "preceding weeks. Corresponding samples were collected in 24", + "age- and sex-matched control subjects. All subsequent studies", + "were carried out in volunteers from this first study. Their daily", + "intake of cigarettes ranged from 15 to 45 (median, 25), and they", + "had 4 to 40 pack-years of smoking (median, 15 years). The", + "THEODORE HERSH, M. 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ittps://www.industrydocuments.ucsf.edu/docs/fqyl0102", + "Circulation Vol 94, No 1 July 1, 1996", + "20", + "rette smokers.2 This is reflective of platelet activation.21.22", + "Prompted by this observation and the knowledge that 8-epi-", + "Selected Abbreviations and Acronyms", + "PGF2., unlike other F1 isoprostanes, may be formed by", + "COX = cyclooxygenase", + "we assessed the effects of aspirin on urinary 8-epi-PGF2. and", + "GC/MS = gas chromatography/mass spectrometry", + "11-dehydro-TxB2 in chronic cigarette smokers. Groups of mod-", + "PG = prostaglandin", + "erate (n=5) and heavy (n=4) smokers collected 24-hour urine", + "TX = thromboxanc", + "samples for analysis of 11-dehydro-TxB2 and 8-epi-PGF2., be-", + "fore (two collections) and after (two collections) dosing with", + "aspirin 75 mg/d for 10 days. TxB2 and 8-epi-PGF2, were", + "frequency of cigarette smoking was assessed by diary records", + "measured in serum samples obtained at the initiation of these", + "and interview. Urinary cotinine, a stable metabolite of nicotine,", + "urine collections. Healthy, nonsmoking control subjects (n=6)", + "was measured in urine samples as an index of nicotine consump-", + "were randomized to receive either aspirin 325 mg as a single", + "tion in volunteers. During these studies they smoked a single", + "oral dose or a matching placebo. Urine (12-hour collections)", + "brand of cigarettes containing 1.2 mg nicotine and 12 mg tar.", + "and serum (at initiation of the urine collections) were collected", + "The second study was a formal assessment of the dose-", + "before dosing and commencing 12 hours after drug", + "response relationship between the number of cigarettes", + "administration.", + "smoked and urinary 8-epi-PGF2a- Chronic smokers were", + "Finally, the effects of short-term therapy with vitamins E and", + "brought to steady state by smoking either 15 to 30 cigarettes", + "C were assessed in the smokers. Initially, five moderate smok-", + "(median, 23) per day (moderate smokers; n=5) or >30 ciga-", + "ers collected 24-hour urine samples for 8-epi-PGF2a 3 days", + "rettes per day (heavy smokers; n=5; range of number of", + "before and 2 days after receiving vitamin E (Roche Pharma-", + "cigarettes, 31 to 45; median, 38) for at least 7 days before", + "ceuticals; 100 U/d for 5 days). Subsequently, a group of heavy", + "collection of three successive 24-hour urine collections for", + "smokers were allocated to receive (1) vitamin E 400 U twice", + "measurement of 8-epi-PGF2a cotinine, and creatinine. The", + "per day (n=7), (2) vitamin C (Roche Pharmaceuticals) 1 g", + "coefficient of variation of urinary 8-epi-PGF2n for triplicate", + "twice per day (n=5), and (3) a combination of the two vitamins", + "24-hour samples in the 10 volunteers ranged from 0.5% to 15%", + "at these doses (n=4). Urine (24-hour sample) and serum were", + "(median, 2%). Samples were collected in age- and sex-matched", + "collected before (two collections) and at the end of (two", + "nonsmoking volunteers. In 8 nonsmoking volunteers, the coef-", + "collections) the 5-day dosing periods. A 2-week washout inter-", + "ficient of variation for four 12-hour urine samples over a", + "vened between treatments.", + "2-week period ranged from 3% to 19% (median, 10%).", + "The third study was designed to assess the effects of smoking", + "Biochemical Analysis", + "cessation on urinary 8-epi-PGF2 in the cigarette smokers. Six", + "Urinary 8-epi-PGF2. 20.23 and 11-dehydro-TxB22 and serum", + "male chronic smokers (age range, 20 to 47 years; median, 32", + "TxB225 were measured by GC/MS as we have previously", + "years) who had smoked >30 cigarettes per day for at least 2", + "described. Values were expressed as picomoles per millimole of", + "weeks (range, 2 weeks to 10 years) performed two 24-hour", + "creatinine (urine) or picomoles per millitier (serum). Urinary", + "collections for 8-epi-PGF2a, creatinine, and cotinine just before", + "cotinine was measured by radioimmunoassay,\" and levels were", + "quitting. They were placed on nicotine patches (Nicotinell, 21", + "expressed as nanomoles per millimole of creatinine.", + "mg/d; Ciba Geigy Pharmaceuticals) on completion of the", + "collection and were maintained on them while urine was", + "Statistical Analysis", + "collected for analyses on days 13, 14, 20, and 21 after quitting.", + "Sample size calculations were based on the desire to detect a", + "We have previously described the increment in urinary", + "difference of at least 50% with a=.05 and a power (1-B) - = .9.", + "thromboxane metabolites observed in apparently healthy ciga-", + "AA", + "Fig 1. Membrane-bound arachidonic", + "acid (AA) may undergo attack by free", + "COOM", + "radicals (FR) in situ on phospholipids.", + "aspirin", + "antioxidants", + "Thermodynamic parameters control", + "this chain reaction of peroxidation and", + "reduction yielding 8-epi-PGF2u and", + "PLA2", + "FR", + "other stereoisomers of PGF20 called", + "isoprostanes (including PGF2... which,", + "AA", + "however, is not thermodynamically fa-", + "cox", + "vored). Alternatively, AA, which has", + "been cleaved from the membrane by", + "phopholipase A2, may be metabolized", + "PGH2", + "by a COX. Enzyme-dependent peroxi-", + "dation and reduction yields PGH2", + "PG syn", + "Tx syn", + "which is subsequently metabolized to", + "TxA2 and other prostaglandins (*PGF2,", + "F2-isoprostanes", + "is illustrated here). 8-epi-PGF2. is", + "8-epi PGF2a", + "TxA2", + "PG*", + "formed as a minor product of COX", + "turnover in activated platelets. Aspirin", + "-", + "prevents the COX-dependent forma-", + "COOM", + "COOM", + "COOM", + "o", + "tion of 8-epi-PGF2, Antioxidants", + "might be expected to inhibit the free", + "-", + "5", + "on", + "-", + "-", + "radical pathway." + ] + }, + { + "bbox": [ + [ + 0.172727, + 0.081279, + 0.018263, + 0.006525 + ], + [ + 0.516765, + 0.083387, + 0.016645, + 0.006459 + ], + [ + 0.516592, + 0.100205, + 0.016668, + 0.006399 + ], + [ + 0.173013, + 0.111715, + 0.017464, + 0.007145 + ], + [ + 0.517418, + 0.117651, + 0.015864, + 0.00661 + ], + [ + 0.517581, + 0.134693, + 0.015752, + 0.006257 + ], + [ + 0.173039, + 0.142534, + 0.017544, + 0.00674 + ], + [ + 0.517281, + 0.151414, + 0.016094, + 0.006328 + ], + [ + 0.517464, + 0.168382, + 0.015888, + 0.006515 + ], + [ + 0.178166, + 0.17303, + 0.012484, + 0.006989 + ], + [ + 0.517345, + 0.185535, + 0.015979, + 0.00609 + ], + [ + 0.289645, + 0.193014, + 0.007041, + 0.008361 + ], + [ + 0.522165, + 0.202123, + 0.011178, + 0.006388 + ], + [ + 0.178049, + 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"80", + "100", + "T", + "80", + "60", + "60", + "40", + "40", + "20", + "20", + "0", + "0", + "Fig 3. Higher levels of urinary 8-epi-PGF2a (open columns) were", + "non-smokers", + "smokers", + "seen in heavy smokers (n=5) compared with age- and sex-", + "matched moderate smokers (n=5; *P<.05 and with nonsmok-", + "Fig 2. 8-epi-PGF20 levels in spot urine samples of smokers", + "ing control subjects (n=14; \"P<.005). Urinary cotinine levels", + "(n=24) compared with age- and sex-matched control subjects", + "(solid columns) were significantly higher in heavy smokers com-", + "(n=24; *P<.005).", + "pared with moderate smokers (*P<.05) and nonsmokers", + "An unpaired t test was used when two samples were being", + "compared. More than two samples were compared by a one-", + "way ANOVA and, if significant differences occurred, by Dun-", + "can multiple range tests to assess where the difference lay. The", + "within-cell median was used as a response variable for smoking", + "cessation data and vitamin data and analyzed as a one-way", + "ANOVA with repeated measures by use of a general linear", + "model. All data are expressed as and differences", + "were considered significant at a value of P<.05.", + "Results", + "Urinary 8-epi-PGF20 excretion was significantly in-", + "creased in the cross-sectional study (Fig 2) in the chronic", + "smokers (122.5=10.8 [mean+SEM] pmol/mmol creati-", + "nine) compared with the age- and sex-matched non-", + "smoking control subjects (63.7+5.0 pmol/mmol creati-", + "nine; P<.005).", + "A dose-response relationship was observed between", + "the number of cigarettes smoked and both urinary", + "cotinine and urinary 8-epi-PGF2a (Fig 3). Heavy smokers", + "had an average excretion of 8-epi-PGF20 of 176.5+30.6", + "pmol/mmol creatinine compared with 92.7=4.8 pmol/", + "mmol creatinine in moderate smokers (P<.05) and", + "54.1+2.7 pmol/mmol creatinine in matched nonsmoking", + "control subjects (P<.005). Smoking was a significant", + "variable (F=28.4; P<.0001) in 8-epi-PGF20 excretion.", + "Furthermore, pairwise comparison indicated a signifi-", + "cant difference between the moderate smokers and both", + "the nonsmoking and heavy-smoking groups. Urinary", + "cotinine levels were 2199+376 nmol/mmol creatinine in", + "heavy smokers compared with 630+33 nmol/mmol cre-", + "atinine in moderate smokers (P<.05) and 32=3.2 nmol/", + "mmol creatinine in nonsmokers (P<.005). The Pearson", + "correlation coefficient for urinary values of 8-epi-PGF20", + "and cotinine in all smokers was .46 (P=.09) (Fig 4). Thus,", + "a tendency for 8-epi-PGF2n to correlate with urinary cotin-", + "ine failed to attain conventional statistical significance.", + "Urinary 8-epi-PGF20 fell significantly on cessation of", + "smoking in the heavy smokers (Fig 5A). Although the", + "data exhibited heterogeneity, the levels fell from a", + "precessation mean of 145.5+24.9 pmol/mmol creatinine", + "to 114.6+27.1 (P<.05) at 2 weeks and remained sup-", + "566941648", + "PRODUCED FROM B&W WEB SITE", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqyl0102", + "Reilly et al", + "21", + "Oxidant Stress in Smokers", + "2500", + "2000", + "1500", + "1000", + "500", + "0", + "heavy", + "moderate", + "non", + "smokers", + "smokers", + "smokers", + "(*P<.005).", + "pressed at 112.6+24.9 (P<.05) 3 weeks after quitting.", + "Smoking was a significant variable in urinary cotinine", + "excretion (F=14.6; P<.0001); levels, as expected, fell", + "after quitting (Fig 5B) and remained at a plateau level", + "consistent with nicotine patch supplementation (preces-", + "sation mean, 2312=751 nmol/mmol creatinine; week 1,", + "982+334; week 2, 928=340; week 3, 871+334).", + "Inhibition of COX by aspirin treatment significantly", + "suppressed thromboxane biosynthesis in vivo, as re-", + "flected by urinary excretion of 11-dehydro-TxB2, in all", + "groups tested (Fig 6A). Levels (in pmol/mmol creati-", + "nine, mean SEM) fell from 158.4+14.4 to 39.3=10.4 in", + "nonsmokers (P<.005), 200.8=21.5 to 70.09.2 in mod-", + "erate smokers (P<.005), and 419.6+21.8 to 105.9=9.8 in", + "heavy smokers (P<.005). Smoking was a significant vari-", + "300", + "250", + "200", + "150", + "= 0.45569", + "P 0.088", + "100", + "50", + "0", + "6000", + "5000", + "4000", + "3000", + "2000", + "1000", + "o", + "urinary cotinine nmol / mmol creatinine", + "Fig 4. Correlation (r=.46; P=.09) of urinary 8-epi-PGF2a and", + "cotinine in chronic smokers (n=15). 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Percent change in the urinary levels of 8-epi-PGF2a and", + "cotinine in six chronic smokers after smoking cessation and", + "nicotine patch supplementation. A, 8-epi-PGF20 levels fell signif-", + "licantly by week 2 and remained suppressed through week 3", + "(*P<.05). B, Cotinine levels dropped dramatically by week 1", + "(**P<.005) and remained at a plateau through weeks 2 and 3.", + "able in urinary 11-dehydro-TxB2 excretion before aspirin", + "administration (F=46.3; P<.0001), and pairwise analysis", + "revealed a significant difference between heavy smokers", + "and both moderate smokers and nonsmokers. Concomi-", + "tantly, aspirin reduced ex vivo serum TxB2 production by", + ">97% in all groups (Fig 7). Urinary 8-epi-PGF20 by", + "contrast, was uninfluenced by aspirin administration even", + "in heavy smokers who had significantly raised levels", + "(P<.05) (Fig 6B). However, aspirin did suppress serum", + "8-epi-PGF20 by roughly 80% ex vivo in moderate and heavy", + "smokers (Fig7). Urinary cotinine levels were similar before", + "and after aspirin administration.", + "Vitamin E (100 U [moderate smokers] or 800 U", + "[heavy smokers) per day) failed to suppress urinary", + "8-epi-PGF2a excretion (Table). Vitamin C, by contrast,", + "administered at 2 g/d, significantly depressed urinary", + "8-epi-PGF2a alone and in combination with vitamin E", + "(800 U/d).", + "Discussion", + "Vitamin E, high dose", + "Vitamin C", + "Isoprostanes belong to a family of free radical-cata-", + "lyzed products of arachidonic acid. 16,27,28 F2 isoprostanes", + "are formed in response to oxidant stress, initially in situ,", + "via the formation of peroxyl radicals of arachidonic acid", + "in the phospholipid29 (Fig 1). Subsequent cleavage and", + "release into plasma appear to result from the action of a", + "566941649", + "PRODUCED FROM B&W WEB SITE", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqyl0102", + "Circulation Vol 94, No 1 July 1, 1996", + "22", + "A) Urinary 8-epi PGF", + "A) Urinary 8-epi PGF,", + "20-", + "120", + "250", + "100", + "200", + "80", + "150", + "60", + "100", + "40", + "50", + "20", + "0", + "0", + "B) Urinary 11 dehydro TxB2", + "500", + "B) Urinary cotinine", + "..", + "120", + "400", + "100", + "300", + "80", + "200", + "60", + ".", + ".", + "100", + "40", + "***", + "20", + "0", + "heavy", + "moderate", + "non", + "0", + "Fig 6. The effect of aspirin (pre, open columns; post, solid", + "week 1", + "week 3", + "week 2", + "pre", + "columns) in nonsmokers (n=6), moderate smokers (n=5), and", + "heavy smokers (n=4) on urinary 8-epi-PGF2, and 11-dehydro-", + "TxB2 A, Aspirin failed to suppress urinary 8-epi-PGF2. excretion", + "in any group. B, Urinary 11-dehydro-TxB2 levels were signifi-", + "cantly depressed by aspirin in all groups (**P<.005).", + "phospholipase A2. One of the more abundant F2 isopros-", + "tanes, 8-epi-PGF2a, exhibits biological activity. It is a", + "vasoconstrictor in the renal and pulmonary vasculature", + "and a mitogen in vascular smooth muscle cells. 17,19,30", + "Although these effects are blocked by antagonists of the", + "thromboxane receptor, 8-epi-PGF2, differs from throm-", + "boxane analogues in its effects on platelets, in which it", + "induces a shape change response but not irreversible", + "aggregation. 31.32", + "Given its potential as both an endogenous ligand for", + "the thromboxane receptor and a marker of oxidant stress", + "in vivo, we developed a specific and sensitive assay for", + "Effect of Vitamin E, Vitamin C, and a Combination of", + "the Two on Urinary 8-epi-PGF20 Excretion", + "Urinary 8-epi-PGF2n", + "pmol/mmol creatinine", + "Before", + "After", + "Treatment", + "Treatment", + "Treatment", + "P", + "100.2=12.1", + "NS", + "106.3=14:4", + "NS", + "172.1=29.8", + "163.0=27.9", + "<.05", + "194.6+40.9", + "137.3=34.2", + "171.0+39.8", + "<.05", + "133.4=29.6", + "Vitamin E, low dose", + "Vitamin E+C", + "Neither vitamin E in low dose (n=5 moderate smokers) nor in high dose", + "(n=7 heavy smokers) reduced urinary 8-epi-PGF2n but both vitamin C", + "(n=5 heavy smokers) and the combination of vitamins (n=4 heavy", + "smokers) significantly suppressed urinary 8-epi-PGF2n levels (P<.05).", + "Values are mean+SEM." + ] + }, + { + "bbox": [ + [ + 0.133025, + 0.326998, + 0.33869, + 0.0099 + ], + [ + 0.13245, + 0.33742, + 0.33951, + 0.00949 + ], + [ + 0.132582, + 0.347574, + 0.339617, + 0.009823 + ], + [ + 0.132712, + 0.35806, + 0.225946, + 0.009858 + ], + [ + 0.132255, + 0.38358, + 0.339251, + 0.01171 + ], + [ + 0.132884, + 0.396124, + 0.338936, + 0.009342 + ], + [ + 0.133189, + 0.408212, + 0.338888, + 0.01161 + ], + [ + 0.132925, + 0.420425, + 0.339379, + 0.011414 + ], + [ + 0.132726, + 0.43267, + 0.339155, + 0.011198 + ], + [ + 0.132487, + 0.444708, + 0.339784, + 0.011052 + ], + [ + 0.132489, + 0.456277, + 0.339077, + 0.011208 + ], + [ + 0.132609, + 0.468323, + 0.339107, + 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"Fig 7. The percent change in serum 8-epi-PGF20 (open col-", + "umns) and TxB2 (solid columns) in heavy smokers (n=4) treated", + "with aspirin (75 mg/d for 10 days). Suppression of both com-", + "pounds by aspirin was significant (P<.01).", + "8-epi-PGF2a 21) Previously, biosynthesis of F2 isopros-", + "tanes has been estimated with an internal standard for", + "the COX product of arachidonic acid, PGF2 16 Using", + "this latter approach, Morrow and colleagues18 recently", + "reported increased formation of these compounds in", + "cigarette smokers. We performed a series of studies that", + "extend these observations and support the utility of the", + "specific measurement of 8-epi-PGF20 as an index of free", + "radical generation in vivo.", + "First, urinary 8-epi-PGF2a is elevated in apparently", + "healthy cigarette smokers compared with age- and sex-", + "matched control subjects. Furthermore, this distinction", + "was apparent whether the comparison was based on", + "\"spot\" urine collections or on aliquots of varied duration", + "(12 or 24 hours). Together with the availability of a", + "GC/MS-validated immunoassay for this compound,33", + "this observation greatly enhances the potential utility of", + "this approach to the study of oxidant stress in vivo.", + "Second, there was a relationship between the number", + "of cigarettes smoked and 8-epi-PGF2a excretion. Thus,", + "urinary 8-epi-PGF2a was higher in individuals smoking", + "more than 30 cigarettes per day than in those smoking 15", + "to 30 cigarettes per day. Urinary cotinine was also higher", + "in the heavy smokers and tended to correlate with", + "urinary 8-epi-PGF2a However, this particular relation-", + "ship did not attain conventional statistical significance", + "(r=.46; p=.09). This is unsurprising, because the effects", + "of nicotine, of which cotinine is a urinary metabolite,34", + "on 8-epi-PGF20 may be quite distinct from those of", + "cigarette smoking. Indeed, the precise constituents of", + "cigarette smoke that contribute to 8-epi-PGF2a excretion", + "in smokers are unclear. Cigarette tar contains stable", + "semiquinone free radicals, which, in aqueous solutions", + "such as pulmonary fluid and plasma, are capable of", + "reducing oxygen to superoxide, with subsequent dismu-", + "tation to hydrogen peroxide. 35,36 Metal ions in cigarette", + "tar and body fluids can catalyze the formation of the", + "hydroxyl radical from hydrogen peroxide via the Fenton", + "reaction. Furthermore, the gas phase of cigarette smoke", + "contains highly unstable organic radicals that are main-", + "566941650", + "PRODUCED FROM B&W WEB SITE", + "120", + "100", + "80", + "60", + "40", + "20", + "0", + "pre", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqyl0102", + "Reilly et al Oxidant Stress in Smokers", + "tained in smoke for prolonged periods (>10 minutes).", + "Nitric oxide and isoprene play a central role in this self-", + "sustaining process by producing alkoxyl and peroxyl", + "radicals. 36,37 These, in turn, may react with superoxide in", + "aqueous solutions to form peroxynitrite.", + "Finally, the degree to which free radicals might gen-", + "erate isoprostanes directly or via activation of mono-", + "cytes, macrophages, and platelets, which, in turn, them-", + "selves generate free radicals, remains to be established.", + "Thus, although both urinary cotinine and 8-epi-PGF2,", + "fell when the heavy smokers were switched to nicotine", + "patches, this is consistent with both indexes reflecting", + "consequences of cigarette smoking, rather than neces-", + "sarily implying a causal relationship between them.", + "Interestingly, on smoking cessation, urinary 8-epi-PGF20", + "failed to decline to levels observed in nonsmokers. This", + "implies that abstention from smoking for 3 weeks re-", + "duces but does not abolish the oxidant stress associated", + "with chronic, heavy cigarette smoking. Alternatively, it is", + "possible that the ex-smokers were exposed to significant", + "post", + "passive smoking in their homes or social environment.", + "Indeed, a number of smokers did come from smoking", + "households. However, the effect of such environmental", + "influences on baseline 8-epi-PGF2a excretion was not", + "assessed formally.", + "8-epi-PGF2a differs from other F2 isoprostanes in that", + "biological activity has been ascribed to it, as mentioned", + "previously. It is unclear whether it might act as an", + "incidental ligand at the thromboxane receptor,3 activate", + "a related but distinct receptor, or exhibit no autacoidal", + "activity in vivo. 8-epi-PGF20 does not activate the recom-", + "binant PGF20 receptor in in vitro expression systems (A.", + "Ford-Hutchinson, PhD, personal communication, 1994).", + "Intuitively, it would be surprising if a product of lipid", + "oxidation might have its own receptor. However, we", + "have observed recently that 8-epi-PGF2a, as distinct from", + "other F2 isoprostanes, can be formed in small amounts", + "by the COX-1 enzyme in activated human platelets20", + "(Fig 1). Thus, it is important to determine the extent to", + "which an increment in urinary 8-epi-PGF2a in cigarette", + "smokers reflects free radical-catalyzed or COX-depen-", + "dent formation of the compound in vivo. This is partic-", + "ularly true in the case of cigarette smoking, in which we", + "have previously described elevated excretion of throm-", + "boxane metabolites, reflective of both platelet activation", + "and increased COX turnover. 21.22", + "Inhibition of platelet COX-1 by aspirin consump-", + "completely suppressed serum TxB2 in the smok-", + "ers ex vivo. Serum concentrations of 8-epi-PGF2a, which", + "are considerably lower than those of TxB2 (733=220", + "pmol/L versus 513=70 nmol/L), are also suppressed by", + "aspirin consumption by the smokers, but to a lesser", + "extent than was the case with TxB2 (mean, 82% versus", + "mean, 98%). Serum 8-epi-PGF20 levels were similar in", + "moderate and heavy smokers at baseline (data not", + "shown). This is not surprising, since there is precedence", + "for equivalent serum levels despite significant differ-", + "ences in urinary production of TxB2 in nonsmokers,", + "moderate smokers, and heavy smokers.2 Thus, it ap-", + "pears that both a COX-dependent and a COX-indepen-", + "dent component of 8-epi-PGF2a generation are present", + "in human serum. However, measurement of 8-epi-PGF20", + "in serum samples heated to 37°C for 1 hour25 is probably", + "reflective of the capacity for product formation in serum", + "rather than actual biosynthesis. 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However, while aspirin", + "administration suppressed urinary 11-dehydro-TxB2, excre-", + "tion of 8-epi-PGF2a was unaltered. These results suggest", + "that although the COX-dependent pathway may be a", + "significant contributor to serum 8-epi-PGF20 production ex", + "vivo, it remains a trivial component of overall 8-epi-PGF20", + "biosynthesis, as reflected by urinary production. This holds", + "true even in the setting of moderate COX activation, such", + "as occurs in heavy cigarette smokers. Whether this holds", + "true in settings of more marked platelet or neutrophil", + "activation remains to be addressed. Similarly, although", + "studies of the disposition of 8-epi-PGF2, are under way, it is", + "probable that, like that of urinary prostaglandin metabo-", + "lites, its utility will be as a noninvasive time-integrated", + "index of total body biosynthesis of this isoprostane. The", + "relative tissue contribution to urinary levels would be", + "expected to vary as a function of the disease under study.43", + "The availability of a quantitative index of oxidant", + "stress in vivo would permit investigation of the dose-", + "response relationship of antioxidant drugs in vivo and", + "their rational evaluation in relevant models of disease.", + "For example, vitamins E and C exhibit antioxidant", + "properties at concentrations used in vitro,44.45 but little", + "information is available as to the antioxidant properties", + "in vivo of minimal daily allowances, of doses used in", + "pharmacological supplementation studies, or of the wide", + "range of intakes incidental to consumption of unre-", + "stricted diets. It is perhaps unsurprising that attempts to", + "define benefit derived in vivo from these and other", + "antioxidant strategies have been frustrating, whether", + "they involved interventional studies46,41 or population-", + "based approaches. 48-50", + "We used the chronic cigarette smokers to evaluate the", + "consequences of short-term administration of two anti-", + "oxidant vitamins on urinary 8-epi-PGF20 In contrast to", + "the effects of aspirin, administration of vitamin C, 2 g/d", + "for 5 days, resulted in a significant decline of 8-epi-PGF2a", + "by an average 29%. A similar significant depression of", + "8-epi-PGF2. excretion (mean, 23%) was observed when", + "the smokers were treated with vitamin E 800 U/d in", + "combination with vitamin C. Interestingly, vitamin E", + "alone, at either 100 U/d (in moderate smokers) or 800", + "U/d (in heavy smokers), failed to suppress 8-epi-PGF2,", + "excretion significantly. The apparent efficacy of vitamin", + "C is not surprising, given the depleted levels of this", + "vitamin that have been demonstrated in chronic smok-", + "ers.5 Furthermore, vitamin C has been shown to be", + "superior to vitamin E in protecting plasma lipids and", + "LDL from oxidative stress. 45,52 This appears to be par-", + "ticularly important in plasma exposed to the gas phase of", + "cigarette smoke, since lipid peroxidation is initiated only", + "after vitamin C has been consumed.4 Despite the inabil-", + "ity of the hydrophobic vitamin C to suppress oxidation in", + "lipophilic membranes, it recycles vitamin E within the", + "lipid membrane, prolonging its antioxidant effect.53", + "Thus, the relative deficiency of vitamin C in cigarette", + "smokers may limit the antioxidant efficacy of vitamin E", + "administered alone. Indeed, an increased rate of HDL", + "oxidation has been reported in cigarette smokers who", + "received supplemental vitamin E compared with re-", + "Source: https://www.industrydocuments.ucsf.edu/docs/fqyl0102", + "duced HDL oxidation in smokers administered a com-", + "bination of vitamin E and vitamin C.54 These observa-", + "tions illustrate the potential utility of 8-epi-PGF2, in", + "antioxidant dose-finding and have prompted the initia-", + "tion of a more detailed investigation of the interaction of", + "dose and duration of therapy with antioxidant vitamins", + "on 8-epi-PGF20 excretion.", + "Our results are consistent with the observations of two", + "other groups. Those investigators used a measurement", + "of either F2 isoprostanes or 8-oxo-7,8-dihydro-2-deox-", + "yguanosine, the latter thought to reflect repair of DNA", + "and its precursors after free radical attack. 18,55 Collec-", + "tively, these results suggest that coincident with but", + "distinct from platelet activation, apparently healthy in-", + "dividuals who smoke cigarettes exhibit abnormal levels", + "of oxidant stress in vivo. The present study is also consis-", + "tent with our finding of elevated urinary 8-epi-PGF2n in", + "other conditions putatively associated with oxidant stress,", + "including reperfusion injury, adult respiratory distress syn-", + "drome, and poisoning with acetaminophen and paraquat.54", + "Elevated 8-epi-PGF20 in chronic smokers may be reduced", + "by quitting smoking and switching to nicotine patches or by", + "antioxidant vitamin therapy.", + "Acknowledgments", + "This study was supported by a Program Grant from the", + "Wellcome Trust (Dr FitzGerald) and research fellowships from", + "the Health Research Board of Ireland (Dr Reilly), the Well-", + "come Trust (Dr Delanty), and the Irish Heart Foundation (Dr", + "Reilly and Dr Delanty). Dr FitzGerald is the Robinette Foun-", + "dation Professor of Cardiovascular Medicine. We are indebted", + "to Peader McGinn, PhD, for his technical assistance, Andy", + "Cucchiara, PhD, for advice on statistical analysis of the data,", + "and Emer Smyth, PhD, for assistance in preparation of the", + "manuscript.", + "References", + "1. US Department of Health and Human Services. The Health Con-", + "sequences of Smoking: 25 Years of Progress. A Report of the Surgeon", + "General. US Department of Health and Human Services, Public", + "Health Service, Centers for Disease Control, Center for Chronic", + "Disease Prevention and Health Promotion, Office on Smoking and", + "Health. Washington, DC: DHHS publication (CDC) 89-8411; 1989.", + "2. Peto R, Lopez AD, Boreham J, Thun M, Heath C Jr. Mortality", + "from tobacco in developed countries: indirect estimates from", + "national vital statistics. Lancet. 1992;339:1268-1278.", + "3. Kita T, Yokode M, Arai H, Hyama M, Ueda Y, Ueyama K,", + "Narumiya S. 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gathering", + "of supporters here, \"I'm trying to give the American", + ":", + "people a realistic choice.\" Anderson, who fought a", + "losing battle against Ronald Reagan for the GOP", + "presidential nomination before launching his inde-", + "pendent bid, must collect 10,000 signatures of regis-", + "tered voters by May 16 to get on the Nov. 4 ballot in", + "North Carolina,", + "But even if he does, few Tar Heel political ob-", + "servers give him much chance to upset the probable", + "major party nominees, Reagan and Jimmy Carter.", + "Anderson said his chances in North Carolina are bet", + "tert than slim.", + "Anderson spoke at an outdoor plaza in Charlotte", + "before flying commercially to Winston-Salem for a", + "news conference, fund-raising reception and speech", + "at Wake Forest University. At the reception, at the", + "Hyatt House hotel, he described the broad coalition", + "of Americans he hopes to rally to his cause. \"I'm ask-", + "ing people to take a leave of absence from some of", + "AP insorphoto", + ":", + "the partisan loyalties to which they usually adhere,\"", + "he said, adding that he also wants the votes of those", + "Anderson In Charlotte", + "\"who have just been on the sidelines\" politically in", + "past elections.", + "Candidate Visited Neuspaper There", + "Reporters, Secret Service agents and campaign", + "to rescue the American hostages in Iran, he said eco-", + "staff members almost outnumbered the reception's", + "nomic and diplomatic means of seeking their release", + "approximately 40 guests, who were asked to contrib-", + "\"would seem to \"me the wise course of action to", + "uteto Anderson's campaign. Among those attending", + "pursue.\"", + "were John Ehle, a Winston-Salem author; Dave Neal", + "of Winston-Salem, U.S. Rep. Steve Neal's brother;", + "If élected, he said, his priorities would include", + "James Clotfelter, a UNC-G political science profes-", + "implementing long-range economic planning to re-", + "sor; and Wallace Carroll, former publisher of the", + "duce inflation, considering ways to revamp and mod-", + "Winston-Salem Journal.`", + "ernize \"the military establishment of this country\"", + "and reorganizing the federal government.", + "-", + "During a brief news conference, Anderson said", + "he opposes prayer in public schools, preferring to", + "In Charlotte, Anderson said he objects to the", + "leave it in the home, and opposes a cutback now in", + "federal government subsidizing tobacco exports", + "the food stamp program, currently in danger. of run-", + "while encouraging Americans to stop smoking. But", + "ning out of funds.", + "he sidestepped the question of whether he supports", + "the domestic tobacco price support system, saying,", + "Asked his opinion on launching another mission", + "\"I would want time to study that further.\"", + "Greastor Daily News", + "may 1980", + "TI4679-2064", + "Source: ttps://www.industrydocuments.ucsf.edu/docs/fyhd0148" + ] + }, + { + "bbox": [ + [ + 0.071568, + 0.039742, + 0.05944, + 0.017187 + ], + [ + 0.076195, + 0.067295, + 0.093843, + 0.039047 + ], + [ + 0.248541, + 0.117317, + 0.445657, + 0.033562 + ], + [ + 0.24746, + 0.1553, + 0.434574, + 0.033189 + ], + [ + 0.262452, + 0.193719, + 0.459568, + 0.012587 + ], + [ + 0.249046, + 0.206042, + 0.228805, + 0.011176 + ], + [ + 0.495782, + 0.204884, + 0.226962, + 0.011543 + ], + [ + 0.249561, + 0.217019, + 0.228584, + 0.010844 + ], + [ + 0.496034, + 0.215589, + 0.226864, + 0.01147 + ], + [ + 0.249507, + 0.227792, + 0.227929, + 0.011211 + ], + [ + 0.496018, + 0.22657, + 0.227571, + 0.00993 + ], + 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He was flying to Miami today", + "polities with our urban crisis,\" inde-", + "for discussions with local govern-", + "pendent presidential candidate John", + "ment officials on aid to victims of re-", + "B. Anderson today proposed a jobs", + "cent racial violence before flying on", + "program under which inner-city", + "to Seattle.", + "youths be paid 85 per cent of the", + "federal minimum wage.", + "Of Carter's urban policies, Ander-", + "son said federal grants to cities", + "In remarks prepared for delivery", + "\"have from the very first been", + "to the annual meeting of the U.S.", + "awarded all too often on the basis of", + "Conference of Mayors, Anderson de-", + "congressional or local political", + "clared, \"The most obvious challenge", + "clout.\"", + "that faces all of us is the problem of", + "youth unemployment.'", + "\"We all should expect the federal", + "government to do more than play", + "He said President Carter has \"put", + "politics with our urban crisis,\" he", + "politics ahead of policy\" in the", + "said.", + "administration's urban programs.", + "\"The federal government has", + "Outlining a series of proposals to", + "played games too long with the fu-", + "aid the nation's big cities, Anderson", + "ture of urban America. \"We do not", + "said his proposed federal program", + "have an administration which is", + "would allow employers to hire", + "trying to build a concensus for", + "young blacks and members of other", + "change or new direction. We. do not", + "minorities at 85 percent or more of", + "have leadership which is willing to", + "the existing minimum wage of $3.10", + "speak frankly and directly about the", + "an hour.", + "problems of urban America in the", + "next decade.\"", + "[", + "The Republican congressman also", + "said federal excise tax revenue from", + "To get on the November general", + "alcohol and tobacco should be di-", + "election ballot in Washington state,", + "verted to hard-pressed municipal-", + "Anderson needs the support of 159", + "ities \"on an equitable basis, free", + "persons at a convention later this", + "from political influence,\" and called", + "month. That makes Washington one", + "for a federal housing policy \"which", + "of the easiest states for Anderson to", + "emphasizes conservation over new", + "become a competitor in the fall.", + "construction.\"", + "By contrast, in California, where", + "Most of the mayors are supporting", + "he was scheduled to go later today,", + "Carter for re-election, and Anderson", + "101,000 signatures must be gathered", + "has few allies among them.", + "on petitions by August to qualify", + "The president is expected to ad-", + "Anderson for the general election.", + "TI4679-2045", + "Source: https://www.industrydocuments.ucsf.edu/docs/fyhd0148" + ] + }, + { + "bbox": [ + [ + 0.558511, + 0.122486, + 0.005226, + 0.008272 + ], + [ + 0.609429, + 0.120825, + 0.141512, + 0.020681 + ], + [ + 0.553208, + 0.15463, + 0.014227, + 0.010501 + ], + [ + 0.611169, + 0.150273, + 0.181292, + 0.020369 + ], + [ + 0.807551, + 0.160127, + 0.059102, + 0.006399 + ], + [ + 0.183209, + 0.1668, + 0.116782, + 0.011751 + ], 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He spoke today, June 9, 1980,", + "at 10:00 a.m. Pacific time at the convention of the U.S.", + "Conference of Mayors in Seattle, Washington.", + "The Anderson proposal, according to one observer at", + "the conference, could result in mayors encouraging the con-", + "sumption of cigarettes in order to reap the benefit of the", + "ear marked cigarette taxes. This comment was made to me", + "privately.", + "/clv", + "TI4679-2046", + "Source: https://www.industrydocuments.ucsf.edu/docs/fyhd0148" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004259.json b/doc_00004259.json new file mode 100644 index 0000000000000000000000000000000000000000..ae4900ea35aa66afd1d396b8367bf77ac79692fb --- /dev/null +++ b/doc_00004259.json @@ -0,0 +1,534 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.026497, + 0.157588, + 0.265756, + 0.042596 + ], + [ + 0.092228, + 0.219236, + 0.306168, + 0.024191 + ], + [ + 0.061994, + 0.245136, + 0.454712, + 0.028568 + ], + [ + 0.062985, + 0.265108, + 0.453129, + 0.027002 + ], + [ + 0.068066, + 0.284577, + 0.456929, + 0.024326 + ], + [ + 0.069062, + 0.299552, + 0.50035, + 0.029921 + ], + [ + 0.06358, + 0.336707, + 0.428609, + 0.026738 + ], + [ + 0.072828, + 0.359057, + 0.426847, + 0.028408 + ], + [ + 0.070733, + 0.37931, + 0.4448, + 0.027334 + ], + [ + 0.071058, + 0.396857, + 0.482813, + 0.026123 + ], + [ + 0.079893, 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tumor incidence", + "60% , compared to control values of 29/84", + "mice; tumor incidence 46% Result: Positive", + "effect." + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004260.json b/doc_00004260.json new file mode 100644 index 0000000000000000000000000000000000000000..24f5727116e50664d2c79d198a4f828fcb0e09ac --- /dev/null +++ b/doc_00004260.json @@ -0,0 +1,326 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.719033, + 0.118095, + 0.119375, + 0.017438 + ], + [ + 0.065047, + 0.152499, + 0.109822, + 0.015185 + ], + [ + 0.064951, + 0.182754, + 0.043505, + 0.010124 + ], + [ + 0.258076, + 0.181778, + 0.104853, + 0.011515 + ], + [ + 0.0649, + 0.195806, + 0.038469, + 0.010184 + ], + [ + 0.257936, + 0.194715, + 0.241477, + 0.012483 + ], + [ + 0.064161, + 0.209071, + 0.02449, + 0.010009 + ], + [ + 0.258188, + 0.208158, + 0.637798, + 0.012683 + ], + [ + 0.064901, + 0.222016, + 0.060749, + 0.01202 + ], + [ + 0.259003, + 0.221202, + 0.24133, + 0.012198 + ], + [ + 0.064934, + 0.261375, 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Baker, M. D.", + "Beverly Hills, California", + "on behalf of", + "The American Cancer Society", + "on", + "Bills H. R. 1236, H. R. 6543 and others", + "amending the Cigarette Labeling Act.", + "Committee on Interstate and Foreign Commerce", + "House of Representatives", + "Congress of the United States", + "April, 1969", + "Source:https://www.industrydocuments.ucsf.edu/docs/krlk0104" + ] + }, + { + "bbox": [ + [ + 0.203843, + 0.169968, + 0.637779, + 0.015141 + ], + [ + 0.116434, + 0.205028, + 0.731169, + 0.015382 + ], + [ + 0.11654, + 0.239584, + 0.710123, + 0.014941 + ], + [ + 0.115991, + 0.274241, + 0.735395, + 0.0154 + ], + [ + 0.116113, + 0.309364, + 0.778031, + 0.014464 + ], + [ + 0.115105, + 0.343333, + 0.732125, + 0.014827 + ], + [ + 0.116404, + 0.378211, + 0.500531, + 0.01439 + ], + [ + 0.202829, + 0.412378, + 0.648783, + 0.014516 + ], + [ + 0.115611, + 0.446819, + 0.707858, + 0.0148 + ], + [ + 0.831537, + 0.449934, + 0.010651, + 0.00815 + ], + [ + 0.114563, + 0.481049, + 0.815897, + 0.014627 + ], + [ + 0.115511, + 0.515688, + 0.756427, + 0.014227 + ], + [ + 0.11392, + 0.549686, + 0.790169, + 0.014711 + 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I am Sol R. Baker, a physician", + "in the practice of therapeutic radiology, and Associate Clinical Professor", + "of Radiology at the School of Medicine, University of California, Los Angeles,", + "and Chairman of the American Cancer Society Committee on Tobacco and", + "Cancer. My home is in Beverly Hills, California.", + "It has been five years since the Report of the Surgeon General on", + "Smoking and Health warned -- and I quote \"that cigarette smoking is", + "a", + "health hazard of sufficient importance in the United States to warrant appropriate", + "remedial action. \" End quote. The finds of the 1964 Report were confirmed", + "and extended by supplementary Public Health Service Reports of 1967 and 1968.", + "And may I add -- that in the five years that have ensued, not one", + "medical or scientific group anywhere in the world has denied the basic fact - -", + "that cigarette smoking is hazardous to health. In fact, many of these groups", + "have joined with us in condemning cigarette smoking as a health menace.", + "Every medical association, every public health body, every recognized", + "scientific body that has studied this problem has agreed that cigarette smoking", + "is a serious health risk.", + "Unfortunately, remedial action has not been strong enough.", + "First, let us go back over the past four or five years, and alsò review", + "some of the basic facts about the hazards of cigarette smoking.", + "From 1965, when the Cigarette Labeling and Advertising Act was", + "Source:https://wwwindustrydocuments.ucsf.edu/docs/krlk0104" + ] + }, + { + "bbox": [ + [ + 0.114911, + 0.040553, + 0.15724, + 0.012531 + ], + [ + 0.469757, + 0.039701, + 0.030606, + 0.011215 + ], + [ + 0.115314, + 0.077726, + 0.746469, + 0.016895 + ], + [ + 0.114618, + 0.112593, + 0.772796, + 0.014951 + ], + [ + 0.203175, + 0.147308, + 0.652456, + 0.015741 + ], + [ + 0.116389, + 0.183123, + 0.486246, + 0.014658 + ], 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R. Baker", + "-2-", + "enacted through 1968, more than 210,000 Americans died of lung cancer --", + "we estimate that about 158,000 of those deaths were due to cigarette smoking.", + "In 1965, when the Act was passed, 48,500 Americans died of lung", + "cancer. In 1969, the toll will be close to 60, ,000.", + "I", + "have spoken of lung cancer, but that is not the only disease which", + "strikes cigarette smokers. Although the death rate for lung cancer is ten", + "times as high among regular smokers as among those who never smoked.", + "In passing, let it be noted that for those who smoke two. packs or more a", + "day, the odds are 20 to 1.", + "Of even more importance to me is an undeniable fact: the risk of", + "dying in the prime of life is more than twice as great for men who are heavy", + "1", + "cigarette smokers as for men who are non-smokers", + "That means men", + "in their 40's and 50's, at the peak of their earning power, at a time when", + "their children are about to enter, or have entered, colleges and universities", + "at that period, smokers are twice as likely to die.", + "A government survey indicated that 2 as compared to non-smokers", + "there may be nearly 300,000 additional cases with heart conditions- - heart", + "conditions which otherwise might have not occurred -- among cigarette smoking", + "1. Hammond, E. Cuyler, Smoking in Relation to the Death Rates of One", + "Million Men and Women, National Cancer Institute Monograph No. 19, Study", + "of Cancer and other Chronic Diseases, January, 1966.", + "2. Projections by the National Clearinghouse for Smoking and Health, based", + "on data from the Public Health Service study, Cigarette Smoking and Health", + "Characteristics, May, 1967.", + "Source: https://www.industrydocuments.ucsf.edy/docs/krlk01.04" + ] + }, + { + "bbox": [ + [ + 0.074317, + 0.057407, + 0.157666, + 0.011221 + ], + [ + 0.496502, + 0.056715, + 0.030336, + 0.011229 + ], + [ + 0.117552, + 0.100804, + 0.73548, + 0.015375 + ], + [ + 0.118421, + 0.135854, + 0.739824, + 0.01498 + ], + [ + 0.118612, + 0.17167, + 0.090894, + 0.013551 + ], + [ + 0.272014, + 0.170688, + 0.416603, + 0.014485 + ], + [ + 0.748821, + 0.169238, + 0.121226, + 0.011844 + ], + [ + 0.119378, + 0.20488, + 0.597182, + 0.015441 + ], + [ + 0.206042, + 0.239343, + 0.697562, + 0.014538 + ], + [ + 0.118388, + 0.274129, + 0.721352, + 0.014831 + ], + [ + 0.118174, + 0.307842, + 0.743421, + 0.015497 + ], + [ + 0.117278, + 0.342214, + 0.766759, + 0.014647 + ], + [ + 0.116734, + 0.378059, + 0.382807, + 0.01411 + ], 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R. Baker", + "-3-", + "Americans. Emphysema has become more common. It is estimated that", + "there will be one million \"extra\" cases of emphysema or chronic bronchitis", + "thi s year", + "one million \"extra\" cases of peptic ulcers", + "in those who", + "smoke cigarettes as compared with those who do not smoke.", + "Just to summarize - - the Surgeon General's Report -- which has been", + "supported by many other surveys and reports -- concluded that cigarette", + "smoking is a cause of lung cancer, that itis associated with heart disease,", + "that it is the most important cause of chronic bronchitis, that it substantially", + "increases the risk of premature death.", + "Is it any wonder that we say - - cigarette smoking is hazardous to", + "health? Can there be any reasonable argument?", + "There are bright spots emerging in this once gloomy picture. About", + "21 million Americans have quit smoking cigarettes; according to a recent", + "figure from the Department of Agriculture, 4. 8 billion fewer cigarettes were", + "(than in 1967)", + "sold last year in this country, and there was a drop of a little more than 2 per-", + "cent in the per capita cigarette consumption.", + "These figures are due, in part, to the combined drive of the health", + "agencies, the Public Health Service's Clearinghouse for Smoking and Health,", + "the aroused forces of American medicine, education and all the media.", + "There's a real deterimination to alert the public and particularly youngsters", + "to the hazards of cigarette smoking. We of the American Cancer-Society", + "are deeply indebted to the radio and television industry for the time devoted", + "to our anti-smoking messages. And, of course, we congratulate the Federal", + "Communications Commission for its Ruling which greatly increased the", + "Source:https://www.industrydocuments.ucsf.edu/docs/krlk0104" + ] + }, + { + "bbox": [ + [ + 0.111242, + 0.045374, + 0.157206, + 0.012074 + ], + [ + 0.483332, + 0.044092, + 0.030455, + 0.011465 + ], + [ + 0.110229, + 0.086623, + 0.531032, + 0.015037 + ], + [ + 0.199258, + 0.120134, + 0.662519, + 0.01629 + ], + [ + 0.110535, + 0.155176, + 0.75882, + 0.016433 + ], + [ + 0.11194, + 0.190283, + 0.76415, + 0.016709 + ], + [ + 0.112241, + 0.225207, + 0.782742, + 0.01692 + ], + [ + 0.11088, + 0.261501, + 0.626215, + 0.014927 + ], + [ + 0.199404, + 0.295443, + 0.621548, + 0.015573 + ], + [ + 0.110596, + 0.329401, + 0.747931, + 0.01693 + ], + [ + 0.198462, + 0.363915, + 0.708588, + 0.017359 + ], + [ + 0.110663, + 0.399439, + 0.759231, + 0.016859 + ], + [ + 0.110301, + 0.433021, + 0.791228, + 0.017752 + ], + [ + 0.110512, + 0.46808, + 0.78021, + 0.01706 + ], + [ + 0.110995, + 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+ "Dr. S. R. Baker", + "-4-", + "number of these messages which appeared on the air.", + "I am very encouraged by what is happening today: but let's face it,", + "we have only made a beginning in discouraging cigarette smoking. And I am", + "sorry to say that I see little evidence that the tobacco industry recognizes its", + "responsibility. It still continues to spend money, time, and effort to challenge", + "the ever-increasing evidence of the risks of cigarette smoking.", + "Since the Surgeon General's Report, the cigarette industry has", + "increased its advertising fifty per cent, from $200 million to $300 million.", + "How effective is cigarette advertising? We believe that it is extremely", + "effective in inviting new smokers and in persuading old smokers to continue.", + "One of the worst things about cigarette advertising -- particularly on television", + "and radio -- is the impact it seems to have on those who are making the effort", + "to give up smoking. It is extremely tough for nervous, struggling, irritable", + "men or women, trying to do what they know is best for them and their children,", + "to be constantly invited by witty, expensive, alluring television commercials", + "to return to their dangerous habit.", + "These commercials indicate that the good people smoke cigarettes", + "that it's a happy thing to smoke cigarettes. Through the use of expert advertising", + "agencies, handsome and attractive people, and the talents of good \"pop\"", + "composers, cigarette commercials are entertaining, both to the eye and the ear.", + "Of course, the problem is that these commercials are selling something", + "which can affect the health of hundreds of thousands of persons.", + "Whatever its content, whatever its message, cigarette advertising is", + "designed to lure people into a hazardous habit, and to keep them smoking. The", + "American Cancer Society feels it should be ended. We hope that this can be", + "Source: https://www.industrvdocuments.ucsf.edu/docs/krlk0104" + ] + }, + { + "bbox": [ + [ + 0.117102, + 0.047495, + 0.158753, + 0.013122 + ], + [ + 0.491433, + 0.048379, + 0.03101, + 0.011703 + ], + [ + 0.116959, + 0.081773, + 0.724041, + 0.015205 + ], + [ + 0.116359, + 0.116622, + 0.710533, + 0.015178 + ], + [ + 0.205747, + 0.151519, + 0.628078, + 0.015013 + ], + [ + 0.117191, + 0.186112, + 0.771507, + 0.015292 + ], + [ + 0.116565, + 0.220598, + 0.754497, + 0.015457 + ], + [ + 0.115995, + 0.255612, + 0.77205, + 0.015237 + ], + [ + 0.115887, + 0.289627, + 0.743933, + 0.016255 + ], + [ + 0.115041, + 0.324847, + 0.789823, + 0.015079 + ], + [ + 0.114589, + 0.359501, + 0.377612, + 0.015122 + ], + [ + 0.203826, + 0.393749, + 0.695943, + 0.014804 + ], + [ + 0.116308, + 0.428449, + 0.786329, + 0.014902 + ], + [ + 0.114153, + 0.464456, + 0.059202, + 0.011248 + ], + [ + 0.209116, + 0.496528, + 0.682794, + 0.016041 + ], + [ + 0.114249, + 0.532019, + 0.543755, + 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Baker", + "-5-", + "achieved voluntarily -- by newspapers, magazines, broadcasters and the", + "tobacco industry and there has been modest progress, in this direction.", + "In a recent statement of policy we said, \"The American Cancer", + "Society believes in freedom of choice and the right of adults to decide whether", + "to smoke cigarettes, but we. do not see enough real freedom on this decision", + "in our cigarette infiltrated world. Adult example, peer invitation, glamorous", + "advertising make it too easy for youngsters to start cigarette smoking; and", + "the adult smoker finds his habit confirmed not only by each cigarette he smokes", + "but by a variety of social pressures. \"", + "We must recognize, moreover, that the tobacco industry spends about", + "one-quarter of a billion dollars a year, advertising cigarettes on television and", + "radio.", + "One-quarter of a billion dollars -- that's about $60 million more than", + "the entire 1968 budget of the National Cancer Institute.", + "One-quarter of a billion dollars -- that's about the amount being given", + "by private and public agencies to support cancer research in the United States", + "this year.", + "Clearly, it is time for more remedial action.", + "We do not believe that the Federal Cigarette Labeling Advertising Act", + "which you enacted in 1965 has served its purpose of protecting the people's", + "health. We feel that the measure proposed by Congressman John Moss of", + "California and by 42 of his colleagues is excellent: we heartily approve of", + "its proposal for a more realistic, stronger warning statement on packages", + "and the inclusion of this warning in all cigarette advertising; we endorse the", + "requirement of placing tar and nicotine levels on cigarette packages and in", + "Source: https://www.industrvdocuments.ucsf.edu/docs/krlk0104." + ] + }, + { + "bbox": [ + [ + 0.113863, + 0.050789, + 0.158291, + 0.011911 + ], + [ + 0.47697, + 0.048432, + 0.0314, + 0.013615 + ], + [ + 0.11335, + 0.120119, + 0.117432, + 0.014922 + ], + [ + 0.202884, + 0.154135, + 0.674427, + 0.014848 + ], + [ + 0.113041, + 0.188412, + 0.72723, + 0.01463 + ], + [ + 0.113589, + 0.223742, + 0.212114, + 0.014502 + ], + [ + 0.200924, + 0.256696, + 0.715353, + 0.015471 + ], + [ + 0.112005, + 0.292105, + 0.773633, + 0.01445 + ], + [ + 0.111583, + 0.327048, + 0.75641, + 0.014193 + ], + [ + 0.111649, + 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Baker", + "-6-", + "advertising.", + "The American Cancer Society is firmly opposed to legislation which", + "would extend indefinitely the prohibition against federal or state action on", + "cigarette advertising.", + "In the matter of controlling disease through reducing cigarette smoking,", + "we are confronted with many problems. The situation is developing, people's", + "attitudes and habits are changing very rapidly. It does not seem clear to us", + "what we may face in the future. Therefore, we think it important that you", + "give to the Federal Communications Commission and the Federal Trade", + "Commission the authority to regulate cigarette advertising, under your", + "supervision and reporting regularly to you.", + "The other day, the American Cancer Society had a note from a", + "9 -year-old - girl who wrote \"I don't understand this, on T. V. they have a", + "commercial that says 'don't smoke' and then they have a commercial that", + "says 'smoke Winston'.", + "\"Why do they do this ?\"", + "We think that this young writer has a good point. Our Chairman of", + "the Board of Directors, William B. Lewis, a former advertising executive,", + "said recently, \"it is one of the daffier manifestations of the mad times in which", + "we live that, night after night, after night, on the same TV channel and on", + "the same radio frequency, we hear over and over again the contradictory", + "admonitions \"Smoke. Smoke. Smoke. Don't smoke. Smoke. Smoke) Smoke:", + "Don't smoke. \"", + "Source: vwindustrydocuments.ucsf.edu/docs/krlk0104" + ] + }, + { + "bbox": [ + [ + 0.114756, + 0.073317, + 0.156463, + 0.011208 + ], + [ + 0.504514, + 0.073572, + 0.02773, + 0.01089 + ], + [ + 0.201965, + 0.125215, + 0.625073, + 0.014625 + ], + [ + 0.11371, + 0.159519, + 0.768793, + 0.014782 + ], + [ + 0.115146, + 0.194452, + 0.790925, + 0.014648 + ], + [ + 0.201133, + 0.229703, + 0.664016, + 0.01431 + ], + [ + 0.113521, + 0.264532, + 0.739827, + 0.01451 + ], + [ + 0.11318, + 0.299381, + 0.754323, + 0.014413 + ], + [ + 0.111653, + 0.333564, + 0.743707, + 0.014137 + ], + [ + 0.111739, + 0.368168, + 0.796246, + 0.014739 + ], + [ + 0.112445, + 0.402852, + 0.178006, + 0.01439 + ], + [ + 0.199057, + 0.436549, + 0.706627, + 0.014986 + ], + [ + 0.111959, + 0.471694, + 0.796808, + 0.014301 + ], + [ + 0.111097, + 0.50564, + 0.780008, + 0.014349 + ], + [ + 0.111215, + 0.539551, + 0.809761, + 0.014101 + ], + [ + 0.11075, + 0.573217, + 0.683564, + 0.014349 + 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R. Baker", + "-7.", + "It seems to us that it is time to present in broadcasting a more", + "unified view of cigarette smoking, one that reflects the country's medical and", + "scientific conscience, to viewers and listeners and particularly to young people.", + "We think that the messages against cigarette smoking on television", + "should certainly be continued as a Public Service. They are doing a most", + "effective and important piece of education -- in fact we think they show very", + "well the value of advertising. We feel they are essential and clearly in the", + "public interest. But it is our strong conviction that the advertising of cigarettes", + "should be stopped.", + "My testimony today expresses the official view of the American Cancer", + "Society, further it grows out of my deep personal convictions and the experience", + "of some thirty years as a radiologist. Radiologists see almost all lung cancer", + "patients but unfortunately too many too late. As you know, only about 30 per cent", + "of the lung cancer cases are today diagnosed when they are operable.", + "The", + "disease is such an insidious one and spreads 60 rapidly.", + "I personally have around 90 patients each year with lung cancer, and it is", + "a disheartening business, the more so since their illness is usually the result of", + "cigarette smoking, a habit that is so widely advocated on television. It is", + "saddening to come home from a day at the hospital in which I have shared", + "in the efforts to save a life from lung cancer with a cobalt bomb and to sit", + "before my television and hear a gay, charming invitation to smoke a cigarette.", + "The way to control lung cancer is through prevention and the road to", + "prevention is through avoidance of cigarette smoking. We do not believe that", + "the end of cigarette advertisng will mean an end to cigarette smoking -- but", + "Source https://www industrydocuments.ucsf.edu/docs/krlk01.04" + ] + }, + { + "bbox": [ + [ + 0.166967, + 0.035128, + 0.158394, + 0.011792 + ], + [ + 0.582213, + 0.035492, + 0.030538, + 0.01112 + ], + [ + 0.166431, + 0.086147, + 0.736383, + 0.014781 + ], + [ + 0.166953, + 0.120431, + 0.753381, + 0.014841 + ], + [ + 0.167211, + 0.155131, + 0.75367, + 0.014704 + ], + [ + 0.1654, + 0.189442, + 0.483849, + 0.014688 + ], + [ + 0.255007, + 0.224169, + 0.216804, + 0.014351 + ], + [ + 0.224344, + 0.980817, + 0.553649, + 0.014083 + ] + ], + "poly": [ + [ + { + "X": 0.166967, + "Y": 0.035128 + }, + { + "X": 0.325362, + "Y": 0.035128 + }, + { + "X": 0.325362, + "Y": 0.04692 + }, + { + "X": 0.166967, + "Y": 0.04692 + } + ], + [ + { + "X": 0.582213, + "Y": 0.035492 + }, + { + "X": 0.612751, + "Y": 0.035492 + }, + { + "X": 0.612751, + "Y": 0.046611 + }, + { + "X": 0.582213, + "Y": 0.046611 + } + ], + [ + { + "X": 0.166431, + "Y": 0.086147 + }, + { + "X": 0.902813, + "Y": 0.086147 + }, + { + "X": 0.902813, + "Y": 0.100928 + }, + { + "X": 0.166431, + "Y": 0.100928 + } + ], + [ + { + "X": 0.166953, + "Y": 0.120431 + }, + { + "X": 0.920334, + "Y": 0.120431 + }, + { + "X": 0.920334, + "Y": 0.135272 + }, + { + "X": 0.166953, + "Y": 0.135272 + } + ], + [ + { + "X": 0.167211, + "Y": 0.155131 + }, + { + "X": 0.920881, + "Y": 0.155131 + }, + { + "X": 0.920881, + "Y": 0.169835 + }, + { + "X": 0.167211, + "Y": 0.169835 + } + ], + [ + { + "X": 0.1654, + "Y": 0.189442 + }, + { + "X": 0.649249, + "Y": 0.189442 + }, + { + "X": 0.649249, + "Y": 0.204131 + }, + { + "X": 0.1654, + "Y": 0.204131 + } + ], + [ + { + "X": 0.255007, + "Y": 0.224169 + }, + { + "X": 0.471811, + "Y": 0.224169 + }, + { + "X": 0.471811, + "Y": 0.23852 + }, + { + "X": 0.255007, + "Y": 0.23852 + } + ], + [ + { + "X": 0.224344, + "Y": 0.980817 + }, + { + "X": 0.777993, + "Y": 0.980817 + }, + { + "X": 0.777993, + "Y": 0.9949 + }, + { + "X": 0.224344, + "Y": 0.9949 + } + ] + ], + "score": [ + 0.9869, + 0.9664, + 0.9988, + 0.9988, + 0.9982, + 0.9984, + 0.998, + 0.6559 + ], + "text": [ + "Dr. S.R. Baker", + "-8-", + "we think it will be a major step in its reduction. We believe it is time for", + "all of us in the United States, and particularly those in the tobacco industry,", + "to recognize our responsibility in advertising a product that causes so much", + "hospitalization, disability, and premature death.", + "Thank you very much.", + "Source https://www.industrydocuments.ucsf.edu/docs/krlk0104" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004262.json b/doc_00004262.json new file mode 100644 index 0000000000000000000000000000000000000000..b9ccefdd5db36ce97055872a6096cf88df770e5b --- /dev/null +++ b/doc_00004262.json @@ -0,0 +1,898 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.142513, + 0.14572, + 0.129811, + 0.010674 + ], + [ + 0.141987, + 0.191988, + 0.028099, + 0.011837 + ], + [ + 0.247394, + 0.192062, + 0.013671, + 0.01364 + ], + [ + 0.297465, + 0.192404, + 0.102623, + 0.013185 + ], + [ + 0.24539, + 0.208002, + 0.015528, + 0.012973 + ], + [ + 0.296852, + 0.208043, + 0.118903, + 0.010796 + ], + [ + 0.245444, + 0.223689, + 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+ "SUBJECT:", + "Kennedy Bill Hearing Testimony and Visuals", + "Attached, for your comments and approval, are the following, which will be presented at the", + "Kennedy bill hearing:", + "1)", + "Consortium representative Brenda Richards' draft testimony", + "2)", + "Draft testimony of a retail association representative (group to be determined)", + "3)", + "Draft testimony of Dewey Stokes, President of the Fraternal Order of Police", + "4)", + "Small sizes of the posters that will be display during Charlie Whitley's testimony", + "5)", + "Draft testimony of Ronald Rotunda, a constitutional expert writing about the", + "impact", + "of the Canadian court decision (provided by C&B)", + "6)", + "Draft testimony of Dr. Theodore Blau on addiction (provided by C&B)", + "Please let me know if you have any questions.", + "attachments", + "cc:", + "M. Merkle", + "T14181-6690", + "Source: https://www.industrydocuments.ucsf.edu/docs/fgkb0046" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004263.json b/doc_00004263.json new file mode 100644 index 0000000000000000000000000000000000000000..a637b1298963c9e5393f713b7483c0634c0216ca --- /dev/null +++ b/doc_00004263.json @@ -0,0 +1,664 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.834632, + 0.124155, + 0.027661, + 0.011962 + ], + [ + 0.264588, + 0.21109, + 0.464468, + 0.01144 + ], + [ + 0.265336, + 0.244981, + 0.112493, + 0.011205 + ], + [ + 0.265055, + 0.257245, + 0.039319, + 0.006759 + ], + [ + 0.614759, + 0.273641, + 0.106489, + 0.011062 + ], + [ + 0.264221, + 0.347511, + 0.121072, + 0.01046 + ], + [ + 0.265023, + 0.359923, + 0.089184, + 0.009205 + ], + [ + 0.26501, + 0.371418, + 0.22651, + 0.010369 + ], + [ + 0.265156, + 0.383639, + 0.082298, + 0.010134 + ], + [ + 0.264371, + 0.395503, + 0.066288, + 0.009842 + ], + [ + 0.265175, + 0.407783, + 0.054309, + 0.008811 + ], + [ + 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Crawford,", + "Imasco Ltd.,", + "600 de Maisonneuve Blvd. West,", + "20th Floor,", + "Montreal,", + "H3A 3K7", + "CANADA", + "Dian Pards,", + "Attached is a copy of a letter which I have sent to each", + "of our Group Operations concerning the environmental", + "performance review which the B.A.T Industries Board is to", + "consider in October.", + "Imasco participated in our previous review in 1989 and", + "I very much hope that you will feel able to take part in this", + "year's review.", + "yours smarly", + "Rt", + "Patrick Sheehy", + "BAT Incusiries plc Incorporated in London No 233112 Telegraphic Address Batind London SW1 Telex 915195", + "4" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004264.json b/doc_00004264.json new file mode 100644 index 0000000000000000000000000000000000000000..0c3f4d2a12e7e8ae2e3e5c0b06d6a3fd08649865 --- /dev/null +++ b/doc_00004264.json @@ -0,0 +1,820 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.079216, + 0.287183, + 0.09338, + 0.010892 + 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KS 66534-0130 U.S.A.", + "Telephone: (913)284-2133", + "Telefax: (913) 284-3771", + "Corporate Sales Office", + "Kansas City, Missouri U.S.A.", + "November 29, 1995", + "M", + "BARBARA ARZONKO", + "12 PAGES", + "get 12/7/95", + "Mr. James E. Fay", + "DELTA RESEARCH", + "783 Sunshine Lane", + "Neenah, WI 54956 - U.S.A.", + "Dear James:", + "Thank you for your recent visit to the University of Nebraska to conduct test runs on the Wenger TX-", + "52 for expanded breads. I have enclosed a copy of the data sheets from those tests which record the", + "processing conditions, dryer formulas, product analysis, and product recipes utilized. After reviewing", + "this information, if you should have questions or comments, please do not hesitate to give me a call.", + "It was a pleasure working with you once again and I want to wish you the Happiest of Holidays!", + "Sincerely,", + "WENGER TECHNICAL CENTER", + "Many Alextel", + "Gerry Hertzel", + "Service Technician", + "GMH;krk", + "Enclosure: 951116 Data Sheets", + "cc:", + "Galen Rokey", + "Brad Strahm", + "WENGER³", + "Extrusion processing systems worlduride", + "Source: https://www.industrydocuments.ucsf.edu/docs/fymf0231" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004266.json b/doc_00004266.json new file mode 100644 index 0000000000000000000000000000000000000000..b2ce750c425ad37c13c619c7ac4c666829d9b7a3 --- /dev/null +++ b/doc_00004266.json @@ -0,0 +1,534 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.217392, + 0.9802, + 0.572881, + 0.014634 + ], + [ + 0.320579, + 0.063555, + 0.021855, + 0.011738 + ], + [ + 0.33917, + 0.222873, + 0.035865, + 0.011455 + 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I have spoken with PM and RJR about activating", + "their grassroots regarding Delta Airlines.", + "2. The New York Times editorial page maybe doing", + "something about Congressional members going to events", + "such as our recent Legislative Conference. Walker", + "received some questions on the meeting.", + "Thanks", + "call", + "1875 I Street, N.W. Washington, D.C. 20006", + "CHARLES H. POWERS", + "Senior Vice President", + "Public Affairs", + "THE TOBACCO INSTITUTE", + "800/424-9876 202/457-4861", + "1/31/90", + "TI51511095" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004267.json b/doc_00004267.json new file mode 100644 index 0000000000000000000000000000000000000000..ba95bcd2db2f453f00d258a9247fc50fef183fcb --- /dev/null +++ b/doc_00004267.json @@ -0,0 +1,1080 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.356555, + 0.069865, + 0.282108, + 0.011714 + ], + [ + 0.398534, + 0.092972, + 0.038392, + 0.012554 + ], + [ + 0.563874, + 0.092905, + 0.038936, + 0.012894 + ], + [ + 0.107036, + 0.112828, + 0.216377, + 0.0151 + ], + [ + 0.106602, + 0.129694, + 0.091837, + 0.011737 + ], + [ + 0.384834, + 0.129414, + 0.064673, + 0.013298 + ], + [ + 0.106212, + 0.147993, + 0.212512, + 0.015135 + ], + [ + 0.107042, + 0.164712, + 0.068757, + 0.011964 + ], + [ + 0.38486, + 0.164694, + 0.064764, + 0.012773 + ], + [ + 0.106688, + 0.182862, + 0.18793, + 0.014665 + ], + [ + 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N. N.", + "Division de Nutricion", + "San Buenaventura y Diaducto", + "Tlalpan, México 22, D.J.", + "October 18, 1972", + "Dr.", + "William J. Darby, President", + "The Nutrition Foundation Inc.", + "99 Park Av.", + "New York, N. Yo 10015", + "U.S.A.", + "Dear Dr. Darby:", + "This letter is to thank you for the big help", + "you lend us in the collaboration to obtain the magnifi-", + "cent picture \"Journey into Nutrition\" which was trans-", + "mited through the close T.V. circuit during the IX In-", + "ternational Congress of Nutrition and which without your", + "participation wouldn3t obtain the success it had.", + "Because of custom problems in my country, I", + "couldn't send you the picture; but in few days you will", + "obtain it through A.M.A., which was sent to Dr. James", + "Breeling to whom I asked to send it to you in order to", + "shorten time and the custom difficulties since all the", + "material was sent to the United States in one package.", + "OCT", + "Sinceroly Carlos yours Pere", + "UG", + "Dr. Hidalgo", + "x", + "Secretary, Scientifis Event", + "C.C. Dr. Paul M. Pearson, The Nutrition Foundation Inc.", + "CPH/ban", + "Source: https://www.industrydocuments.ucsf.edu/docs/gnbv0228" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004269.json b/doc_00004269.json new file mode 100644 index 0000000000000000000000000000000000000000..fc5749c8cb3fb57feef93c6ad4a0a1c14c60eb8b --- /dev/null +++ b/doc_00004269.json @@ -0,0 +1,2094 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.093918, + 0.039777, + 0.092249, + 0.009314 + ], + [ + 0.20852, + 0.040177, + 0.132271, + 0.008254 + ], + [ + 0.366664, + 0.039082, + 0.149316, + 0.010525 + ], + [ + 0.099481, + 0.070334, + 0.239438, + 0.011218 + ], + [ + 0.373394, + 0.068432, + 0.383959, + 0.016298 + ], + [ + 0.096659, + 0.119414, + 0.106063, + 0.012863 + ], + [ + 0.499102, + 0.116844, + 0.048008, + 0.011272 + ], + [ + 0.574811, + 0.113587, + 0.093886, + 0.016419 + ], + [ + 0.098171, + 0.138338, + 0.152686, + 0.019945 + ], + [ + 0.499846, + 0.135474, + 0.114626, + 0.012956 + ], + [ + 0.626601, + 0.14464, + 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(a)", + "Keine Spezialbedingungen:", + "Maßnahmen zur Vorbeugung.von mechanischen Effekten:", + "Maßnahmen zur Vorbougung des Auslaufens von Flüßigkeiten:", + "Maximaltemperatú (°C):", + "y.c", + "for", + "x", + "Gefahrliche Eigenschaften des Materials:", + "Geschätzte: Gewicht (kg): 20 kg.", + "Verpackungsmaterial (z.B. 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We will order it.", + "Wednesday, February 18, 1998 8:58 AM", + "RE: G. Weissman & Baruch College", + "Han, Vic; Sarro, Sinikka; Fleming, Brenda; Temple, Richmond; Davenport, Stephanie; Dennis,", + "Moore, Mary Ellen; Grizzaffi, Betty; Liston, Bill; Knox, George; Keenan, Colleen; Colby, Dolly;", + "Erskine, Heather; Macauley, Jack; Zadikow, Jennifer; Puotila, Johan; Sorrells, John; Wallace,", + "Karen; Seda, Kenneth; Magarro, Patches; Roberts, Peggy", + "Gikas, Olga", + "Darienne" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004271.json b/doc_00004271.json new file mode 100644 index 0000000000000000000000000000000000000000..054e77edec3e87d8e31709605ef7f606797ad547 --- /dev/null +++ b/doc_00004271.json @@ -0,0 +1,544 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.91599, + 0.493825, + 0.022491, + 0.012427 + ], + [ + 0.747449, + 0.888832, + 0.165803, + 0.016796 + ], + [ + 0.763825, + 0.930394, + 0.181108, + 0.015425 + ], + [ + 0.224806, + 0.980845, + 0.549263, + 0.016739 + ] + ], + "poly": [ + [ + { + "X": 0.91599, + "Y": 0.493825 + }, + { + "X": 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07.PPT; Prudential Back to School Statement.rtf", + "DSS:", + "PM3038596618", + "8/29/2007", + "3038596618", + "Source: https://www.industrydocuments.ucsf.edu/docs/ffxc0150" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004272.json b/doc_00004272.json new file mode 100644 index 0000000000000000000000000000000000000000..10a7596d23a8cd062f0e31ee01d39f937b9f5fd4 --- /dev/null +++ b/doc_00004272.json @@ -0,0 +1,534 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.286147, + 0.571341, + 0.098885, + 0.348895 + ], + [ + 0.415286, + 0.585818, + 0.106778, + 0.332977 + ], + [ + 0.211644, + 0.587852, + 0.078743, + 0.311702 + ], + [ + 0.140439, + 0.590369, + 0.057382, + 0.328639 + ], + [ + 0.195609, + 0.598098, + 0.034931, + 0.298886 + ], + [ + 0.406047, + 0.573778, + 0.025945, + 0.022743 + ], + [ + 0.43306, + 0.576373, + 0.02435, + 0.024148 + ], + [ + 0.390425, + 0.578215, + 0.029482, + 0.033611 + ], + [ + 0.37865, + 0.579771, + 0.017898, + 0.006281 + ], + [ + 0.639917, + 0.587007, + 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pro-active Grant-making program", + "- Innovative grants in Hunger and Nutrition, Education, and the", + "Arts", + "- Giving program is driven by Project-specific grantmaking.", + "- Limited general grantmaking", + "The Corporate Contributions program is the most", + "effective when the guidelines are adhered to. This", + "allows us to make strategic contributions in", + "selected areas and keep the integrity of the", + "program intact. When the guidelines are followed", + "the possibilty for cristism is deminished. The", + "Public and Government Affair departments need to", + "be made aware of our various funding initiatives in", + "all three focus areas. Efforts will continue to be", + "made to reach out to new and existing constituent", + "groups that you work with to identify projects that", + "fit our focus areas.", + "Education", + "Educating the Future Workforce", + "- programs that support and enhance the critical role of educators", + "and prepare them for new roles in education for the 21st century", + "- new approaches to teacher training", + "- programs that are designed to attract minorities into education", + "careers", + "- program that address adult literacy (Gateway roll-out)", + "~ Teach For America", + "~", + "University of Tennessee", + "Source: https://www.industrydocuments.ucsf.edu/docs/jqnw0025" + ] + }, + { + "bbox": [ + [ + 0.164028, + 0.088397, + 0.703351, + 0.027395 + ], + [ + 0.164096, + 0.135329, + 0.74182, + 0.019367 + ], + [ + 0.163337, + 0.156371, + 0.718115, + 0.019173 + ], + [ + 0.163511, + 0.176713, + 0.759028, + 0.019717 + ], + [ + 0.163313, + 0.19856, + 0.091439, + 0.018577 + ], + [ + 0.600354, + 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The 60 full proposals are reviewed by a", + "non-partisan panel of experts who determine the best proposals for", + "funding.", + "colleges in", + "-", + "Community Colleges - Strengthening the Bridge", + "*", + "233 concept papers submitted from 41 states; 15 were selected", + "- After Colleges were selected, government affairs professionals", + "were involved in check presentation ceremonies - sometimes with", + "legislators.", + "-", + "Tolerance on College Campuses - Establishing Common", + "Ground", + "colleges IN", + "*", + "Over 270 proposals submitted from over 30 states; 20 will be", + "selected", + "- Again, government affairs staff will be involved in check", + "presentation ceremony.", + "- Cited in the Education Chronicle for this initiative", + "2) Congressional Scholarship Program for Future Teachers", + "- Contribution staff works with WRO to identify students for", + "scholarship awards.", + "3) Recruiting New Teachers/National Council of State", + "Legislatures", + "- Joint-Conference fully underwriten by Philip Morris", + "- attended by 25 state legislators and education professionals", + "- Purpose: to meet and discuss education policy and improve", + "teaching force in legislator's home state.", + "Hunger and Nutrition", + "- Helping the Helpers - supports innovative approaches to", + "improving the private voluntary programs that feed the", + "hungry.(All Philip Morris Companies)", + "Source: https://www.industrydocuments.ucsf.edu/docs/jqnw0025" + ] + }, + { + "bbox": [ + [ + 0.154852, + 0.113148, + 0.762257, + 0.019218 + ], + [ + 0.1554, + 0.134014, + 0.750536, + 0.018867 + ], + [ + 0.154733, + 0.15574, + 0.062403, + 0.017662 + ], + [ + 0.153438, + 0.19716, + 0.533534, + 0.019509 + ], + [ + 0.154939, + 0.21846, + 0.737725, + 0.01918 + ], + [ + 0.154317, + 0.239647, + 0.449825, + 0.018945 + ], + [ + 0.177909, + 0.2608, + 0.320813, + 0.018948 + ], + [ + 0.180797, + 0.281404, + 0.247476, + 0.018538 + ], + [ + 0.177858, + 0.302199, + 0.278291, + 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girnsts ITA", + "Continued support to Homebound meal delivery to PWAs", + "- Specialized Diets and nutrition education for PWAs", + "- Chicago, Philadelphia, San Francisco, New York, Washington, DC, Los", + "Angeles,", + "-", + "Government Affairs Connections", + "- Helping the Helpers Program with Washington Relations office", + "Urban Institute Study - Hunger Among the Elderly Survey", + "1) Two Phases", + "- Mail survey to cross-section of elderly", + "- Face to face interviews in 13 communities", + "Latino", + "Native American", + "African American", + "2) Rationale", + "- Opportunity to work in collaborative effort with elderly lobby - a", + "very active and influential lobby on Capital Hill", + "- Foundation to build a credible and far-reaching giving initiative", + "3) Programs - Address food security needs of the elderly in plant", + "communities and/or selected congressional districts", + "- National Hisponic Courial ON Aging", + "~ 180K 3 years", + "~ F-nded under Hunger 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Director Morta 5. tomiyer", + "Source: https://www.industrydocuments.ucsf.edu/docs/jqnw0025" + ] + }, + { + "bbox": [ + [ + 0.163512, + 0.093173, + 0.555745, + 0.018094 + ], + [ + 0.161352, + 0.14399, + 0.763315, + 0.019293 + ], + [ + 0.16154, + 0.163941, + 0.575414, + 0.020062 + ], + [ + 0.161785, + 0.186092, + 0.622318, + 0.019629 + ], + [ + 0.160973, + 0.228346, + 0.18043, + 0.0194 + ], + [ + 0.162496, + 0.249346, + 0.616619, + 0.019276 + ], + [ + 0.161282, + 0.270688, + 0.683751, + 0.018949 + ], + [ + 0.162046, + 0.295532, + 0.108679, + 0.01065 + ], + [ + 0.160726, + 0.312132, + 0.506117, + 0.019168 + ], + [ + 0.160048, + 0.332827, + 0.659559, + 0.019314 + ], + [ + 0.160646, + 0.353524, + 0.714731, + 0.017787 + ], + [ + 0.160999, + 0.375161, + 0.62278, + 0.018804 + ], + [ + 0.161057, + 0.395962, + 0.704179, + 0.019003 + ], + [ + 0.160215, + 0.417346, + 0.31713, + 0.019092 + ], + [ + 0.160141, + 0.43833, + 0.729487, + 0.018907 + ], + [ + 0.159999, + 0.461899, + 0.254599, + 0.015761 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FARONE, Ph.D.", + "Submitted in: Haglund V. Philip Morris", + "Revised 9/17/2007", + "EXPERT REPORT", + "OF", + "EXHIBIT", + "Farone", + "3", + "rice 1/29/08" + ] + }, + { + "bbox": [ + [ + 0.183761, + 0.131488, + 0.697995, + 0.015339 + ], + [ + 0.126363, + 0.167253, + 0.761424, + 0.015799 + ], + [ + 0.12641, + 0.203239, + 0.070581, + 0.015025 + ], + [ + 0.125889, + 0.238946, + 0.012544, + 0.012241 + ], + [ + 0.180133, + 0.238604, + 0.257403, + 0.01445 + ], + [ + 0.179368, + 0.273788, + 0.629613, + 0.015571 + ], + [ + 0.126588, + 0.309218, + 0.763916, + 0.015356 + ], + [ + 0.126732, + 0.344642, + 0.732364, + 0.015483 + ], + [ + 0.125525, + 0.379677, + 0.703829, + 0.015356 + ], + [ + 0.125451, + 0.414649, + 0.753292, + 0.014856 + ], + [ + 0.125196, + 0.44964, + 0.75899, + 0.015459 + ], + [ + 0.125456, + 0.485084, + 0.705636, + 0.015616 + ], + [ + 0.125586, + 0.520317, + 0.73494, + 0.015701 + ], + [ + 0.125268, + 0.555655, + 0.742058, + 0.015684 + ], + [ + 0.12501, + 0.590823, + 0.741168, + 0.015707 + ], + [ + 0.124584, + 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Farone. I have agreed to serve as an expert witness in the matter of", + "Haglund V. Philip Morris, and submit this report and enclosures to set forth a summary of my expert", + "opinions.", + "I.", + "Background and Qualifications", + "I am a professional scientist with a background in engineering. I have training and", + "experience in the cigarette industry. My Curriculum Vitae is attached. I am currently President and", + "Chief Executive Officer of Applied Power Concepts, Inc., in California. In 1976 I joined Philip", + "Morris USA, then a subsidiary of Philip Morris Inc., in a staff position reporting to the Vice-", + "President of Research & Development. From 1977 to 1984 I was Director of Applied Research for", + "Philip Morris Inc. in Richmond, Virginia. I hold a Ph.D. in physical chemistry, a M.S. in chemistry", + "and a B.S. in chemistry with honors. I have published over 90 papers in the areas of physics,", + "chemistry, biotechnology and management techniques, and made over 60 technical presentations", + "addressing similar areas. I hold a number of chemical, electrical and biotechnology patents. I am", + "currently an advisor to the National Cancer Institute and the World Health Organization on issues", + "dealing with cigarette and nicotine chemistry and biochemistry and cigarette design.", + "I joined Lever Brothers in 1967 and was made Director of Scientific Research in 1972. Other", + "positions with that company are reflected in my Curriculum Vitae. As Director of Scientific", + "Research, I acted as the government regulatory agency liaison, which involved filings of New Drug", + "Applications, OTC panel submissions, Food Additive Petitions and other submissions to the Food", + "and Drug Administration (\"FDA\"), Federal Trade Commission (\"FTC\"), Consumer Product Safety", + "Commission (\"CPSC\"), and the Environmental Protection Agency (\"EPA\"). As a result, I am", + "-2-", + "3990178006", + "3990178006", + "Source: https://www..industry.documents.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.126941, + 0.132823, + 0.718339, + 0.015623 + ], + [ + 0.127259, + 0.168252, + 0.732029, + 0.01558 + ], + [ + 0.126835, + 0.2047, + 0.757955, + 0.01553 + ], + [ + 0.126154, + 0.240522, + 0.756301, + 0.015451 + ], + [ + 0.125851, + 0.276562, + 0.762807, + 0.015373 + ], + [ + 0.130793, + 0.31223, + 0.763356, + 0.01558 + ], + [ + 0.125799, + 0.347464, + 0.73631, + 0.015532 + ], + [ + 0.125429, + 0.383067, + 0.756027, + 0.015635 + ], + [ + 0.125223, + 0.418295, + 0.34809, + 0.015429 + ], + [ + 0.180633, + 0.453715, + 0.681805, + 0.015315 + ], + [ + 0.124992, + 0.489108, + 0.758174, + 0.014934 + ], + [ + 0.124213, + 0.523655, + 0.705373, + 0.015776 + ], + [ + 0.124153, + 0.559464, + 0.755197, + 0.015358 + ], + [ + 0.12402, + 0.595034, + 0.16029, + 0.015478 + ], + [ + 0.17976, + 0.630206, + 0.705618, + 0.015303 + ], + [ + 0.123797, + 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I was also responsible for new and existing product research for household products,", + "toiletries, foods and personal products in the areas of physical chemistry, toxicology, biochemistry,", + "microbiology, process engineering and organic chemistry. At Lever Brothers, biological-or animal-", + "testing was important, indeed required to ensure the safety of the products being sold for human use", + "and to obtain marketing approval. Equally important was \"whole product\" testing, or testing the", + "product \"as sold.\" This was important - and properly required - to ensure that the combined effect", + "of the product components were not harmful.", + "In 1975, 1 left Lever Brothers to become Vice President of Research and Development at", + "PVO, International, a company involved in development and manufacture of chemical products for", + "the food, cosmetics, toiletries, medical supplies and detergent industries. While with PVO, I", + "maintained a research program for development of new products and provided technical support to", + "the marketing group.", + "I was approached by Philip Morris in 1975, and invited to join the company in a senior staff", + "position in order to learn the background in all the ongoing research programs and then to become a", + "Director of Research. The interest expressed in my background by Philip Morris was directed at", + "suggestions that I would make to change their research programs. This led to my becoming Director", + "of Applied Research in 1977. I accepted the offer believing that I was to direct efforts 1) to help", + "Philip Morris diversify away from dependence on the cigarette business and 2) to help develop", + "\"safer\" cigarette products, as evidenced by the results of standard toxicological tests. During my", + "tenure with Philip Morris, I supervised five divisions that employed approximately 150 persons with", + "-3-", + "3990178007", + "3990178007", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.130572, + 0.130345, + 0.753881, + 0.015804 + ], + [ + 0.13085, + 0.165918, + 0.748306, + 0.015478 + ], + [ + 0.129754, + 0.201545, + 0.687526, + 0.01504 + ], + [ + 0.129474, + 0.236736, + 0.745325, + 0.01503 + ], + [ + 0.129526, + 0.272167, + 0.67686, + 0.01536 + ], + [ + 0.129088, + 0.307246, + 0.715183, + 0.015736 + ], + [ + 0.186323, + 0.342812, + 0.689304, + 0.015577 + ], + [ + 0.129383, + 0.378055, + 0.712953, + 0.015758 + ], + [ + 0.128043, + 0.413894, + 0.740368, + 0.015348 + ], + [ + 0.128387, + 0.449396, + 0.758567, + 0.01571 + ], + [ + 0.128543, + 0.484518, + 0.723525, + 0.015542 + ], + [ + 0.855268, + 0.484803, + 0.008082, + 0.01156 + ], + [ + 0.128145, + 0.519699, + 0.693739, + 0.015332 + ], + [ + 0.128381, + 0.554701, + 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I and my staff developed new technologies and processes", + "which could, if implemented, change the nature of cigarette making, including producing cigarettes", + "that demonstrated less toxicity in toxicological testing, and thus had the potential to be less", + "hazardous for smokers. Despite the potential advances facilitated by these technologies during my", + "tenure at Philip Morris, many of these technologies were not put to commercial use in the", + "manufacture of cigarettes despite the fact that they were economically and technically feasible.", + "I left Philip Morris in 1984, following which I formed Applied Power Concepts. The work", + "of this company is described more fully in my Curriculum Vitae. In 1994, I was contacted by", + "representatives of the FDA and was asked to provide information regarding the tobacco industry's", + "use of cigarette manufacturing and design processes to regulate the levels and delivery of nicotine in", + "cigarettes. In the decade prior to my acquiescence to the government's request for information,", + "I", + "was not involved in any litigation or regulatory proceedings involving Philip Morris. I was,", + "however, threatened with litigation by Philip Morris for publicly admitting that cigarette smoking", + "caused disease. I maintained my interest in cigarette technology and my company pursued the", + "improvement of a carbon monoxide reduction catalyst similar to one which we developed at Philip", + "Morris.", + "Since my testimony before the FDA, I have been asked to testify in a number of lawsuits", + "against Philip Morris and other cigarette companies. I have testified as a fact and expert witness in", + "cases against tobacco manufacturers and in other matters.", + "II.", + "Scope of Testimony", + "In addition to the expert testimony described herein, I understand that I may be asked to testify", + "and provide opinions regarding the analysis and conclusions of other experts in this case, and I may also", + "-4-", + "3990178008", + "3990178008", + "Source: https://www.industrydocuments.ucsf.odu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.121616, + 0.134873, + 0.763283, + 0.015771 + ], + [ + 0.121099, + 0.170921, + 0.764101, + 0.015457 + ], + [ + 0.121461, + 0.206313, + 0.763451, + 0.015598 + ], + [ + 0.120891, + 0.241952, + 0.743135, + 0.015503 + ], + [ + 0.868506, + 0.242956, + 0.016035, + 0.011641 + ], + [ + 0.12109, + 0.276804, + 0.763898, + 0.015179 + ], + [ + 0.121005, + 0.312089, + 0.765688, + 0.015923 + ], + [ + 0.12013, + 0.34751, + 0.43779, + 0.015193 + ], + [ + 0.119416, + 0.382471, + 0.028349, + 0.012061 + ], + [ + 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These matters include, without limitation, descriptions of research projects conducted at Philip", + "Morris, discussions of developing and possibly marketing a less harmful cigarette, the reasons for the", + "paucity of biological testing, the reasons for not marketing truly less harmful cigarettes, the risk", + "in", + "litigation of certain research, the destruction or concealment of certain documents, the consensus view", + "of Philip Morris scientists of the dangers of smoking, the addictiveness of smoking, the manipulation of", + "nicotine, and the design and marketing of light cigarettes.", + "III.", + "Basis of Report", + "This report is based on my experience with Philip Morris, my contact with others who work in", + "the tobacco industry, my employment and experience outside the tobacco industry, my education and", + "training and my review and knowledge of tobacco industry documents. These documents include: (1)", + "Philip Morris documents that concern research on cigarette design and manufacture that occurred while", + "I", + "was at Philip Morris and for which I received or read copies while at Philip Morris; (2) Philip Morris", + "documents created both during and after my employment at Philip Morris to which I first gained access", + "well after I left Philip Morris; and (3) other industry documents.", + "In addition to the publicly available documents specifically referred to within this report, the", + "other specific documents that I rely on, all of which are enclosed, are as follows:", + "(a)", + "(3) CDs marked as Farone 1-3;", + "(b)", + "Comments on Tobacco Industry Comments to FDA by William A. Farone, Ph.D, January", + "9, 1998 (hard copy enclosed);", + "(c)", + "The Recent Chemistry of Natural Products, Including Tobacco - Proceedings of the", + "Second Philip Morris Science Symposium, October 30, 1975 (hard copy enclosed);", + "-5-", + "3990178009", + "3990178009", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.178056, + 0.135478, + 0.022203, + 0.015209 + ], + [ + 0.235038, + 0.135337, + 0.651362, + 0.015754 + ], + [ + 0.119948, + 0.171067, + 0.350243, + 0.015516 + ], + [ + 0.177927, + 0.206764, + 0.020596, + 0.014857 + ], + [ + 0.234148, + 0.206901, + 0.500239, + 0.01507 + ], + [ + 0.177754, + 0.242449, + 0.018227, + 0.014522 + ], + [ + 0.234251, + 0.242236, + 0.652477, + 0.015506 + ], + [ + 0.119718, + 0.277695, + 0.16419, + 0.015333 + ], + [ + 0.153555, + 0.313016, + 0.732115, + 0.015999 + ], + [ + 0.118759, + 0.348412, + 0.767194, + 0.015518 + ], + [ + 0.119156, + 0.383825, + 0.76657, + 0.015291 + ], + [ + 0.118646, + 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enclosed).", + "In addition to this report, I am also submitting in a CD marked Farone 4, my direct testimony in US", + "V. Philip Morris, et al. In many instances, this transcript describes in greater detail the substance of my", + "anticipated testimony in this case, and I also incorporate by reference the Exhibits that are identified", + "within the transcript.", + "IV. Discussion", + "A. Cigarettes are addictive and hazardous when used as intended", + "I", + "understand and scientifically conclude that cigarettes are extremely hazardous when", + "used as intended. They cause lung cancer, kidney cancer and cancer of other organs, chronic", + "obstructive pulmonary disease, and cardiovascular disease, among other conditions. I accept as", + "scientifically valid the epidemiology expressed in the Surgeon General's reports on the Health", + "Consequences of Smoking. Tobacco-induced deaths make up at least 35% of all fatal conditions in", + "males ages 35 to 69. Analyzing a study by the American Cancer Society on the death rates from", + "smoking, the report concludes that between 40% and 50% of regular cigarette smokers will", + "eventually be killed as a consequence of their addiction.", + "In addition, cigarettes are addictive when used as intended. Nicotine in cigarettes is a primary", + "cause of addiction, a fact recognized by Philip Morris decades ago. The purpose and function of a", + "cigarette is to deliver nicotine to the smoker. Nicotine is a potent drug with a variety of physiological", + "-6-", + "3990178010", + "3990178010", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.122096, + 0.131082, + 0.764627, + 0.016071 + ], + [ + 0.121765, + 0.167237, + 0.764006, + 0.016159 + ], + [ + 0.121784, + 0.203377, + 0.763553, + 0.015852 + ], + [ + 0.120566, + 0.238738, + 0.764722, + 0.015999 + ], + [ + 0.120968, + 0.274727, + 0.763541, + 0.015144 + ], + [ + 0.121116, + 0.309565, + 0.423427, + 0.015727 + ], + [ + 0.175016, + 0.345966, + 0.676882, + 0.015433 + ], + [ + 0.119673, + 0.381201, + 0.754928, + 0.015533 + ], + [ + 0.119235, + 0.416749, + 0.76333, + 0.015209 + ], + [ + 0.119605, + 0.451804, + 0.751132, + 0.015272 + ], + [ + 0.119817, + 0.487488, + 0.684714, + 0.015386 + ], + [ + 0.178762, + 0.540777, + 0.017641, + 0.011569 + ], + [ + 0.233872, + 0.541052, + 0.621486, + 0.015337 + ], + [ + 0.121091, + 0.558654, + 0.222173, + 0.014632 + ], + [ + 0.178362, + 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Nicotine is known to be a habit-forming alkaloid. The mission of tobacco companies, including", + "Philip Morris, has long been to design, manufacture and sell a nicotine delivery device, cigarettes, to", + "smokers. An important consideration in cigarette design for Philip Morris during my tenure there was", + "maintaining a level of nicotine sufficient to produce customer satisfaction. Based on the scientific", + "studies reviewed by the FDA in 1995, the conclusions of which I have further analyzed, 85% (77% to", + "92%) of cigarette smokers become addicted to nicotine.", + "Modern cigarette products have failed to incorporate feasible modifications which would", + "have materially enhanced their safety without unduly compromising their utility. It was known and", + "understood by the cigarette companies the levels of reductions in carcinogens reasonably required to", + "significantly reduce the risk of smoking. It was also known that the way the product is used by the", + "consumer would result in the consumer defeating any small benefit from low tar products.", + "B.", + "Tobacco companies, including Philip Morris, have long known that cigarette", + "smoke delivers carcinogens", + "Cigarette smoke contains hazardous levels of carcinogens and harmful substances. Over 40", + "compounds in cigarette smoke are known carcinogens. These include compounds from chemical", + "groups such as the polyaromatic hydrocarbons (including benzo (a)pyrene), N-Nitrosamines,", + "aromatic amines, aldehydes, and other organic and inorganic compounds.", + "The research conducted on disease-causing agents in cigarette smoke was extensive. The", + "industry found classes or grouping of chemical compounds that related to \"biological activity.\" The", + "term \"biological activity\" was adopted by the industry for their products to encompass all of the", + "chemical effects of mutagenicity, carcinogenicity and teratogenicity. It became known that", + "nitrosamines, especially tobacco-specific nitrosamines, were among the most harmful compounds in", + "-7-", + "3990178011", + "3990178011", + "Source: https://www.industrydocuments.ucsf.edu/docs/htv184" + ] + }, + { + "bbox": [ + [ + 0.125355, + 0.133363, + 0.751008, + 0.015838 + ], + [ + 0.125034, + 0.169451, + 0.758699, + 0.015475 + ], + [ + 0.124485, + 0.205137, + 0.725946, + 0.014565 + ], + [ + 0.124973, + 0.240703, + 0.749642, + 0.014992 + ], + [ + 0.124565, + 0.275823, + 0.723167, + 0.015336 + ], + [ + 0.851499, + 0.275952, + 0.018296, + 0.012183 + ], + [ + 0.123698, + 0.311232, + 0.710145, + 0.015656 + ], + [ + 0.123964, + 0.34678, + 0.759861, + 0.015608 + ], + [ + 0.123344, + 0.38258, + 0.450939, + 0.01527 + ], + [ + 0.128089, + 0.417794, + 0.721784, + 0.0154 + ], + [ + 0.12342, + 0.453444, + 0.734277, + 0.015281 + ], + [ + 0.123501, + 0.488289, + 0.754014, + 0.015378 + ], + [ + 0.123419, + 0.523652, + 0.745734, + 0.015696 + ], + [ + 0.12299, + 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Of lesser importance, but still studied extensively and linked to a significant", + "number of deaths annually, is the unintentional but avoidable inclusion of excessive radioactive", + "isotopes in and on tobacco. The tobacco companies' agreement not to compete among themselves", + "on health issues and not to conduct meaningful biological research stifled development and use", + "of", + "technologies which would remove these hazardous components and produce a safer cigarette.", + "During the last 25 years tobacco companies have deliberately added chemicals to tobacce known to-", + "present a risk of damage to smokers including carcinogens.", + "While the tobacco companies publicly proclaimed a lack of evidence to establish a relationship", + "between smoking and disease, research from various cigarette manufacturers and that which was", + "secretly conducted by the industry-funded and controlled Tobacco Industry Research Council (later", + "called the Center for Tobacco Research) and the Tobacco Institute proved and confirmed the large", + "amount of other scientific evidence that cigarette smoke was mutagenic and teratogenic, and that it", + "was biologically active on numerous toxicological protocols designed to evaluate safety and", + "carcinogenicity. However, the industry did not truthfully report these tests or the knowledge that it", + "obtained from them to the public. The tobacco industry deliberately did not perform animal or cell-", + "testing on branded cigarettes as sold so that the public could reasonably determine whether \"low tar'", + "products represented as less harmful (for example, Carlton, Now and Cambridge) were in fact likely", + "to be less hazardous than high tar products such as Marlbore and Winston. The industry introduced", + "the concept of \"Light\" and \"Ultra Light\" to imply reduced risk but in many cases the tar deliveries", + "of these products were above the tar deliveries of products not branded as \"Light\" or \"Ultra Light\".", + "In some cases the tar deliveries of \"Lights\" and \"Ultra Light\" products were above or equal to the", + "-8-", + "3990178012", + "3990178012", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.122856, + 0.131875, + 0.755875, + 0.015706 + ], + [ + 0.122546, + 0.167308, + 0.738756, + 0.015243 + ], + [ + 0.122941, + 0.203312, + 0.758373, + 0.015406 + ], + [ + 0.122152, + 0.239314, + 0.318442, + 0.015551 + ], + [ + 0.18355, + 0.310776, + 0.652365, + 0.015413 + ], + [ + 0.121856, + 0.328951, + 0.235292, + 0.015212 + ], + [ + 0.179156, + 0.363673, + 0.680506, + 0.01555 + ], + [ + 0.121439, + 0.398991, + 0.746321, + 0.015736 + ], + [ + 0.121065, + 0.434901, + 0.745125, + 0.015409 + ], + [ + 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Cigarettes containing menthol", + "were sold in order to make it easier for consumers to inhale even more of the deadly carcinogens", + "and to mask the unpleasant taste of alkaloids such as nicotine developed at high levels based on the", + "way consumers actually use the products.", + "C. Cigarettes are designed by the tobacco industry, including Philip Morris, to", + "develop and create addiction", + "While I was at Philip Morris, it was clear to me that the modern cigarette is designed and", + "manufactured as meticulously and thoroughly as drug products are by pharmaceutical companies.", + "Indeed, the type and quality of research at Philip Morris, and the level of understanding about the", + "biochemical and pharmacological properties of its products, was as sophisticated as any I", + "encountered at Lever Brothers or in the current work of my company.", + "From my work and experience at Philip Morris, and from my professional training, it is my", + "view that the modern cigarette combines several technologies specifically designed and intended to", + "make it more inhalable and addictive. In particular, the development of cigarette making machines", + "that create and use \"fine cut\" tobacco and the use of casings and flavorings have made the cigarette", + "smoke more inhalable and thus more addictive. Modern cigarette products are designed to induce", + "addiction, and thus to ensure lifelong customers - who engage in lifelong self-administration", + "of", + "lethal doses of toxic substances that are delivered along with nicotine. Additives such as menthol", + "and other flavorings make it easier for consumers to overcome the natural aversion of putting smoke", + "in their lungs.", + "One of the design criteria for low tar cigarettes such as Marlboro Lights was ensuring", + "delivery of a dose of nicotine sufficient to create and sustain addiction. That objective was achieved", + "-9-", + "3990178013", + "3990178013", + "Source: https://www.industrydocuments.ucsf.edu/docs/htiv0184" + ] + }, + { + "bbox": [ + [ + 0.129748, + 0.136591, + 0.758608, + 0.01545 + ], + [ + 0.128923, + 0.172033, + 0.76646, + 0.015761 + ], + [ + 0.12907, + 0.207233, + 0.751697, + 0.016003 + ], + [ + 0.128636, + 0.242799, + 0.752251, + 0.015685 + ], + [ + 0.128921, + 0.278179, + 0.700992, + 0.015503 + ], + [ + 0.128437, + 0.313806, + 0.760228, + 0.015416 + ], + [ + 0.127918, + 0.349655, + 0.730322, + 0.015351 + ], + [ + 0.127796, + 0.384852, + 0.71123, + 0.015168 + ], + [ + 0.127696, + 0.420157, + 0.611541, + 0.01592 + ], + [ + 0.127359, + 0.455727, + 0.766509, + 0.015202 + ], + [ + 0.126616, + 0.490888, + 0.769735, + 0.015466 + ], + [ + 0.126496, + 0.526031, + 0.767578, + 0.015709 + ], + [ + 0.1265, + 0.561421, + 0.766862, + 0.015623 + ], + [ + 0.126256, + 0.597011, + 0.766983, + 0.015723 + ], + [ + 0.12607, + 0.632541, + 0.766741, + 0.015293 + ], + [ + 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The research conducted by Philip Morris showed that in response to low yield", + "cigarettes, such as its Marlboro Lights and Cambridge Lights, smokers' puff volume increased and", + "the number of cigarettes smoked per day increased. The Maxwell reports, which were relied on by", + "Philip Morris and others in the industry clearly show an increase in the number of cigarettes", + "smoked. At the time I went to work at Philip Morris in the 1970's, there existed plenty of data from", + "the switching studies in the Maxwell reports that showed the increased cigarettes per day effect.", + "This phenomenon called compensation was well-known in the late 70s and was mentioned in", + "Goodman and Gilman (a standard reference on pharmacology and therapeutics).", + "During my tenure at Philip Morris we began or continued developing other mechanisms for increasing", + "nicotine delivery including: 1) increase in free base nicotine; 2) ventilation blockage; 3) addition of", + "nicotine reinforcers to the smoke; 4) addition of chemicals that mimic nicotine. The last category", + "includes pyridine and pyrazines - pyridine is listed as an additive and pyrazines, pyrazoles, pyradizines,", + "etc. were made by Philip Morris in \"cooked flavors\" that were added in the 1980s. Many of the", + "chemical additives to Philip Morris cigarettes are nicotine analogs, i.e. they have structures that will", + "induce some central nervous system activity according to their Material Safety Data Sheets. All of", + "these phenomena were studied by Philip Morris, and cigarette designs were changed based upon each of", + "these.", + "Ensuring delivery of a dose of nicotine sufficient to create and sustain addiction was a design", + "criterion of the cigarette, achieved through the following ways:", + "(1) Manipulation of nicotine levels via cigarette construction technology and tobacco", + "blend selection.", + "-10-", + "3990178014", + "3990178014", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.187014, + 0.135388, + 0.700853, + 0.015481 + ], + [ + 0.130334, + 0.170589, + 0.758391, + 0.015304 + ], + [ + 0.130227, + 0.205743, + 0.758012, + 0.015569 + ], + [ + 0.129556, + 0.240907, + 0.758341, + 0.015268 + ], + [ + 0.12931, + 0.276553, + 0.758515, + 0.014607 + ], + [ + 0.129433, + 0.311217, + 0.758296, + 0.015748 + ], + [ + 0.129248, + 0.346705, + 0.758938, + 0.015335 + ], + [ + 0.129133, + 0.381851, + 0.758286, + 0.01513 + ], + [ + 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Tobacco is \"cured\" after it is", + "harvested. This process has an effect on the chemistry of the tobacco. Tobacco may also be \"fermented\"", + "prior to being used in cigarettes, which also affects the chemistry of the tobacco. In addition, there are", + "different species of tobacco plants that vary in their levels of nicotine and other chemicals. All of these", + "factors which affect the amount of tar and nicotine a cigarette will yield are considered by cigarette", + "manufacturers in determining the tobacco to be used in the cigarettes. During my tenure, Philip Morris", + "was buying the high alkaloid content (most nicotinic) tobacco which increases the mutagenicity of", + "cigarettes due to tobacco specific nitrosamines formed from these alkaloids.", + "(2)", + "Increasing nicotine in the vapor phase and/or free nicotine;", + "Philip Morris's characterization of the use of ammonia and other methods of manipulating", + "smoke pH levels merely as flavor technology is misleading. While ammonia, as a base, raises the pH", + "level, the pH of the smoke is not as important as the way ammonia actually works. When ammonia is", + "released during combustion it sweeps along the remaining tobacco, which has been moistened by water,", + "replacing nicotine and causing the nicotine to be released in vapor phase from the tobacco. FTC testing", + "devices do not detect vapor phase nicotine, a fact Philip Morris has known for some time. Thus,", + "reported nicotine levels are regularly lower than actual levels received by a smoker. This, among other", + "things discussed, allows Philip Morris to advertise and promote its light cigarettes using FTC nicotine", + "yields lower than what is actually delivered to the smoker.", + "Furthermore, studies on ammonia use do not accurately report the amount of ammonia present,", + "as they do not also consider the blend composition of the products or the additives used. These factors", + "-11-", + "3990178015", + "3990178015", + "Source: https://www.industrydocumentsucsfedu/docs/htfvo184" + ] + }, + { + "bbox": [ + [ + 0.126221, + 0.137029, + 0.76609, + 0.015764 + ], + [ + 0.125694, + 0.172612, + 0.765899, + 0.015885 + ], + [ + 0.125781, + 0.207361, + 0.349827, + 0.016394 + ], + [ + 0.181198, + 0.243661, + 0.710187, + 0.015352 + ], + [ + 0.125411, + 0.279263, + 0.765578, + 0.015735 + ], + [ + 0.124646, + 0.314815, + 0.769056, + 0.015453 + ], + [ + 0.125144, + 0.350119, + 0.766156, + 0.015369 + ], + [ + 0.124215, + 0.385653, + 0.766744, + 0.015862 + ], + [ + 0.124551, + 0.421072, + 0.766789, + 0.015593 + ], + [ + 0.124461, + 0.456237, + 0.766536, + 0.015339 + ], + [ + 0.124448, + 0.491143, + 0.76669, + 0.014923 + ], + [ + 0.123376, + 0.5267, + 0.673396, + 0.015123 + ], + [ + 0.180608, + 0.561734, + 0.710751, + 0.015969 + ], + [ + 0.123021, + 0.597038, + 0.768165, + 0.016209 + ], + [ + 0.123318, + 0.633386, + 0.768197, + 0.015008 + ], + [ + 0.123046, + 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because it increases nicotine delivery levels, which, as discussed", + "above, are important in order to create, maintain and satisfy nicotine addiction. In fact, the need to", + "precisely control nicotine levels is recognized in internal documents that stress the necessity of", + "controlling for changes in the nicotine content of tobacco in different years and different areas. The", + "industry began studying ammonia technology as early as the 1950s when Claude Teague (RJR)", + "investigated the ammoniation of tobacco. Philip Morris introduced the addition of ammonia to their", + "cigarette products in 1965, and shortly thereafter sales increased for Philip Morris brands including", + "Marlboro. Studies of the effects of ammoniation from the 1970s showed that the process increased the", + "yield of alkaloids including nicotine which, in turn, increased physiological satisfaction.", + "Research as early as 1975 showed that vapor phase nicotine can account for 12% or more of the", + "nicotine delivered in the mainstream smoke cigarettes. Philip Morris has long been aware of the", + "delivery of vapor phase nicotine. For example, when the original Cambridge \"low tar\" cigarette (not", + "Cambridge Lights) was introduced to the market in 1980, its machine measured tar yield was negligible", + "(less than 0.005 mg) while the vapor phase nicotine was still 0.03mg. The use of ammonia to enhance", + "nicotine production is confirmed in Philip Morris's patents and research documents. An analysis", + "of", + "nicotine to tar ratios VS. total ammonia compounds shows a clear correlation between ammoniation and", + "increased nicotine yield. Although Philip Morris has, in the past, cited the Surgeon General's report to", + "support their claim that there is \"virtually\" no \"free\" nicotine in mainstream cigarette smoke, the test", + "referred to only measured nicotine collected on the collection pad of the measuring device; it did not", + "-12-", + "3990178016", + "3990178016", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.126317, + 0.131189, + 0.656751, + 0.015606 + ], + [ + 0.184203, + 0.167215, + 0.712875, + 0.015312 + ], + [ + 0.126542, + 0.202788, + 0.768162, + 0.015369 + ], + [ + 0.125989, + 0.238443, + 0.768178, + 0.015549 + ], + [ + 0.125608, + 0.274138, + 0.768497, + 0.015976 + ], + [ + 0.12588, + 0.310046, + 0.768694, + 0.015463 + ], + [ + 0.125313, + 0.345465, + 0.77114, + 0.015564 + ], + [ + 0.12511, + 0.380743, + 0.768729, + 0.01537 + ], + [ + 0.125134, + 0.416294, + 0.768597, + 0.015606 + ], + [ + 0.125342, + 0.451912, + 0.504268, + 0.015595 + ], + [ + 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"measure vapor phase nicotine. Vapor phase nicotine is virtually all in the \"free\" state.", + "Philip Morris's scientists suggest that pH has not increased over the years. Yet, the smoke pH of", + "certain light cigarettes, or cigarettes with higher nicotine to tar ratios, has increased. The use of pH", + "enhancements was one of the tools used to increase nicotine impact in light cigarettes that began to be", + "introduced in the late 60s and throughout the 70s. Indeed, the pH of cigarette smoke has risen steadily", + "since the late 1960s. A report written by Dr. G. Morie clearly shows that pH at that time was an order", + "of magnitude (about 1 pH unit) lower than the cigarettes tested by the Massachusetts Department of", + "Health recently. In other words, before the tobacco industry started using additional ammonia in its", + "products, the pH for tobacco was much lower. The pH increases have been associated with the", + "introduction of the new \"low tar\" brands including \"light\" brands.", + "Another example of how Philip Morris has actively mislead smokers, regulators and the public", + "generally was through its repeated insistence that nicotine levels are not manipulated. In testimony", + "under oath before Congress in 1994, in concurrent newspaper advertisements, and in response to an", + "FDA inquiry in 1996, the industry, including Philip Morris, collectively denied changing nicotine to tar", + "ratios deliberately. They indicated that the change in nicotine to tar ratios either did not occur or was", + "accidental. Nevertheless, Philip Morris defends its use of ammonia, other additives and blending", + "techniques to increase nicotine levels by claiming that these efforts to \"modify tar/nicotine ratios [were", + "made] in response to the requests of the public health community,' implicitly admitting that sustaining", + "nicotine levels is a conscious objective of its manufacturing techniques.", + "(3)", + "Decreasing particle size through combustion chemistry;", + "When particles are larger than 5-8 micrometers (microns), they deposit in the mouth and throat", + "before they get into the lungs. Smaller particles down to about 0.3 microns enter the lungs but are", + "-13-", + "3990178017", + "3990178017", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.126256, + 0.1319, + 0.767326, + 0.016145 + ], + [ + 0.126304, + 0.167942, + 0.767718, + 0.01572 + ], + [ + 0.1254, + 0.203952, + 0.074369, + 0.01184 + ], + [ + 0.183651, + 0.239504, + 0.710997, + 0.014811 + ], + [ + 0.125285, + 0.274898, + 0.768916, + 0.015289 + ], + [ + 0.124727, + 0.309795, + 0.769332, + 0.015649 + ], + [ + 0.124454, + 0.344846, + 0.769409, + 0.015896 + ], + [ + 0.124468, + 0.380491, + 0.768019, + 0.015289 + ], + [ + 0.182426, + 0.415982, + 0.710721, + 0.015386 + ], + [ + 0.124184, + 0.451179, + 0.768838, + 0.015243 + ], + [ + 0.123982, + 0.486152, + 0.768961, + 0.016062 + ], + [ + 0.123962, + 0.521742, + 0.769446, + 0.015579 + ], + [ + 0.123767, + 0.557128, + 0.771207, + 0.015212 + ], + [ + 0.122966, + 0.592614, + 0.769216, + 0.015643 + ], + [ + 0.12279, + 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As the particles go below 0.3", + "microns in size, more and more of them are retained in the lungs, rapidly approaching virtually total", + "retention.", + "The Cambridge pad used to collect tar and nicotine in the FTC test is 99%+ efficient for", + "removing particles larger than 0.1 micron. With all of the above in mind, one task of a designer of \"low", + "tar\" cigarettes who is trying to make them more \"satisfying\" to the regular smoker is decreasing the", + "particle size to below 0.1 micron. While these particles won't be detected by the FTC test, they actually", + "increase the bioavailability of the nicotine because they are highly retained in the lungs of the smoker.", + "In addition, aerosols are small particles of either liquids or solids suspended in air. They are", + "usually smaller than 10 microns and when they are smaller than 1 micron they are very hard to see", + "unless you see them in reflected light. Tobacco smoke is a predominantly liquid aerosol. Such aerosols", + "are formed by one of two mechanisms. If the air is very clean (no dust or atomized salt) the particles", + "eventually self condense as one might cool a saturated gas. This is called \"homogeneous nucleation\". If", + "there are a lot of dust or salt particles in the air, the liquid will condense on those nuclei. This is called", + "heterogeneous nucleation and is the predominant mechanism of smoke formulation in a cigarette.", + "When the tobacco burns, the liquids are vaporized and the solids (tiny salt crystals) are \"popped\"", + "into the air stream in huge numbers. As the combination cools, the salt crystals become the nuclei", + "for", + "the liquid droplets. This mechanism is what entrains the inorganic toxic materials in the smoke. The", + "more nuclei there are, on average, the smaller will be the particle size distribution. This is logical", + "because, given the increased number of particles (and, hence, the increase in overall surface area), there", + "are more places for the liquid to condense.", + "When there is too much salt in tobacco, the tobacco does not burn as easily. The addition of", + "-14-", + "3990178018", + "3990178018", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.12527, + 0.134644, + 0.765618, + 0.015052 + ], + [ + 0.124373, + 0.169704, + 0.425968, + 0.015266 + ], + [ + 0.182361, + 0.204802, + 0.707861, + 0.015828 + ], + [ + 0.124398, + 0.239767, + 0.76577, + 0.016258 + ], + [ + 0.124199, + 0.275468, + 0.765571, + 0.016185 + ], + [ + 0.124236, + 0.311588, + 0.766317, + 0.015291 + ], + [ + 0.123192, + 0.346888, + 0.766885, + 0.01537 + ], + [ + 0.123618, + 0.382067, + 0.765968, + 0.016135 + ], + [ + 0.123124, + 0.417131, + 0.656893, + 0.016082 + ], + [ + 0.181858, + 0.452741, + 0.707667, + 0.015021 + ], + [ + 0.123378, + 0.487876, + 0.766809, + 0.015074 + ], + [ + 0.123025, + 0.522899, + 0.766471, + 0.015585 + ], + [ + 0.122738, + 0.558371, + 0.766703, + 0.015479 + ], + [ + 0.122516, + 0.593862, + 0.387903, + 0.015545 + ], + [ + 0.180211, + 0.629324, + 0.022413, + 0.01584 + ], + [ + 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(like casings) allows the tobacco to burn while still tolerating a", + "reasonable salt concentration to reduce the particle size.", + "Finally, when the tobacco companies first started to make cigarettes by machine (1910-1920)", + "they found that large pieces of tobacco were hard to keep in the paper. The tobacco also is harder to", + "keep lit (e.g. pipe tobacco, cigar tobacco). They developed the \"fine cut\" where the tobacco is cut into", + "thin strips. The thinner strips have more surface area so the tobacco burns faster, and more salts per unit", + "volume of air so the particle size is smaller. The development of \"fine cut\" tobacco led to the", + "inadvertent discovery of the perfect addictive nicotine device, because it allowed the particles to get into", + "the inhalable range without being deposited in the throat or mouth to as high a degree.", + "One of the objectives in designing lower delivery cigarettes was to decrease the particle size in", + "the aerosols, and to increase the amount of material (including what the Cambridge pad does not", + "measure) coming out of the back end of the filter and into the smoker's lungs to be retained. Philip", + "Morris spent much time and effort researching this in order to create \"light\" cigarettes which still", + "provided effective doses of nicotine to the smoker.", + "(4)", + "Increasing inhalability through tobacco processing, including specification of flavorants,", + "additives and smoke chemistry;", + "In addition to other ingredients, cigarettes contain flavors and casings, which, among other", + "things, change the taste of the smoke. The use of flavorants and filter ventilation dilution in Marlboro", + "Lights and Cambridge Lights may increase smokers' perception that they are lower in tar. The lighter-", + "feeling smoke and reduced resistance to draw increase the inhalability of the smoke.", + "(5)", + "Development of fhigh-porosity paper, low-pressure drop filtration, rapid burning tobacco,", + "and other characteristics to facilitate rapid and repeated product use;", + "-15-", + "3990178019", + "3990178019", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.182887, + 0.131145, + 0.708618, + 0.016048 + ], + [ + 0.125278, + 0.167135, + 0.765744, + 0.015839 + ], + [ + 0.125453, + 0.203076, + 0.765878, + 0.015174 + ], + [ + 0.125169, + 0.238292, + 0.766354, + 0.015146 + ], + [ + 0.124558, + 0.273414, + 0.768753, + 0.015845 + ], + [ + 0.124537, + 0.309503, + 0.768491, + 0.015776 + ], + [ + 0.123948, + 0.345498, + 0.767319, + 0.015388 + ], + [ + 0.123776, + 0.381189, + 0.766941, + 0.015197 + ], + [ + 0.12444, + 0.416617, + 0.766294, + 0.015193 + ], + [ + 0.123803, + 0.451836, + 0.766832, + 0.015389 + ], + [ + 0.124092, + 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"The use of high-porosity paper, low pressure drop filtration and rapid burning tobacco each", + "contribute to cigarettes that are easier to inhale or draw smoke from. For example, design parameters", + "can affect the resistance to draw (RTD) of the cigarette. Ordinarily, faster puff velocity increases the", + "smoke to air ratio of the total puff volume drawn while, also, unfortunately, increasing the mutagenicity", + "of every gram of tar. The low RTD of ventilated light cigarettes encourages not only larger puff", + "volumes, but also faster draw speed which increases both the overall tar yield and the mutagenicity of", + "the tar. Philip Morris had the technology to increase the RTD in order to discourage higher velocity", + "puffs and reduce the mutagenicity of the tar, however, Philip Morris worked very hard to keep the RTD", + "down and to make the RTD as consistent throughout the rod as possible. In fact, Philip Morris", + "understood compensation so well that it designed cigarettes to take advantage of it. Very high RTD", + "filters would have defeated compensation in part, but they were not used because these products can", + "inhibit compensation; the smoker may puff more intensely but still not obtain the amount of nicotine", + "necessary to \"satisfy\" that particular smoker.", + "(6)", + "Utilizing filter ventilation;", + "Another important cigarette design feature resulting in a low machine-measured yield but a", + "higher actual yield is the use of ventilated filters. Holes are cut into the paper wrapping the filter in", + "locations where they are not covered when the cigarettes are placed into the smoking machine.", + "However, the lips or fingers of the smoker can easily cover the holes. When the holes are uncovered and", + "the low draw rates specified by the FTC protocol are used, air is drawn into the smoking machine,", + "diluting the smoke coming through the rod of tobacco and lowering the machine-measured tar values.", + "When the holes are covered, or when the smoker draws more rapidly on the cigarette, much more smoke", + "is drawn through the rod of tobacco and much less air is drawn from the ventilation holes. The result is", + "-16-", + "3990178020", + "3990178020", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.130418, + 0.137935, + 0.585208, + 0.015622 + ], + [ + 0.186805, + 0.173394, + 0.699878, + 0.015102 + ], + [ + 0.130401, + 0.208374, + 0.755268, + 0.015005 + ], + [ + 0.129793, + 0.243939, + 0.754729, + 0.015658 + ], + [ + 0.129477, + 0.278958, + 0.756305, + 0.015688 + ], + [ + 0.129487, + 0.314238, + 0.756295, + 0.014915 + ], + [ + 0.129176, + 0.349102, + 0.755975, + 0.015021 + ], + [ + 0.128581, + 0.384086, + 0.756286, + 0.015399 + ], + [ + 0.129139, + 0.419122, + 0.373837, + 0.015341 + ], + [ + 0.184967, + 0.454024, + 0.699742, + 0.014884 + ], + [ + 0.127981, + 0.488891, + 0.756844, + 0.015449 + ], + [ + 0.128474, + 0.523997, + 0.756457, + 0.015222 + ], + [ + 0.127456, + 0.55881, + 0.757284, + 0.015292 + ], + [ + 0.12701, + 0.593579, + 0.757368, + 0.015163 + ], + [ + 0.126862, + 0.628391, + 0.757132, + 0.015745 + ], + [ + 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Smokers can and do obstruct the", + "vents with either their lips or fingers, thereby diminishing or defeating the air dilution effect.", + "Ventilation hole obstruction in combination with the learned compensatory behaviors of the smoker", + "easily allows most cigarettes to deliver similar amounts of tar and nicotine to cigarette smokers without", + "regard to the amount of tar and nicotine reported by the FTC. The ease with which smokers can", + "unknowingly compensate for low standard yields by changing their puffing profile and interfering with", + "ventilation has long been known to Philip Morris.", + "This dichotomy of delivery between smokers and machines was the intended result of the", + "engineering effort to design elasticity of delivery in cigarettes. While testing of these design concepts", + "on actual smokers revealed that light and regular cigarettes delivered similar levels of tar and nicotine", + "when smoked by smokers (Goodman, 1975), from Philip Morris's perspective these cigarettes satisfied", + "the demand for cigarettes that could be marketed as low-tar cigarettes with full flavor or taste. The low-", + "tar claims presented in advertisements only existed for machine-smoking, while the \"full flavor\"", + "received by the smoker was accompanied by levels of tar increased by compensation for nicotine that", + "delivered full or increased disease risks.", + "As has been stated, many design features were manipulated in order to interact with smoker", + "behavior and to allow smokers to obtain their desired doses of nicotine. Documents show that at the", + "same time Philip Morris made public statements that nicotine was not addictive and smoking was a", + "choice, they were very aware that nicotine was the reason people smoked and that smokers would adjust", + "their smoking habits to attain their desired \"dose\" of finicotine. Nicotine was recognized as critical to the", + "-17-", + "3990178021", + "3990178021", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.1214, + 0.136029, + 0.766068, + 0.015178 + ], + [ + 0.121023, + 0.171398, + 0.766286, + 0.01543 + ], + [ + 0.120016, + 0.206463, + 0.230169, + 0.015379 + ], + [ + 0.176551, + 0.242965, + 0.0194, + 0.012447 + ], + [ + 0.238271, + 0.243005, + 0.234765, + 0.014755 + ], + [ + 0.177962, + 0.277677, + 0.658157, + 0.015421 + ], + [ + 0.120578, + 0.313264, + 0.761675, + 0.015233 + ], + [ + 0.120345, + 0.348247, + 0.726247, + 0.01571 + ], + [ + 0.119633, + 0.383697, + 0.724141, + 0.015638 + ], + [ + 0.11951, + 0.418934, + 0.730029, + 0.01538 + ], + [ + 0.119748, + 0.454097, + 0.748314, + 0.015461 + ], + [ + 0.119313, + 0.489366, + 0.714245, + 0.015027 + ], + [ + 0.11901, + 0.52458, + 0.730768, + 0.015199 + ], + [ + 0.119084, + 0.559704, + 0.743898, + 0.015965 + ], + [ + 0.118714, + 0.595291, + 0.760921, + 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Agreement", + "To my knowledge, none of the tobacco companies has conducted meaningful in-house", + "biological research on cigarettes until the 1990s, at which point the industry finally began to yield to", + "the weight of scientific and public health community opinion. During my tenure as Director of", + "Applied Research at Philip Morris, I repeatedly recommended that such research be conducted.", + "Biological testing of products as marketed is critical to development of less hazardous products.", + "Without meaningful biological research on the product as marketed, it is not possible to determine", + "what effect the product as sold may have on users. It is and was well known that pyrolysis of", + "tobacco and the use of additives creates a complex mix of thousands of chemicals. I considered", + "biological research to be the responsible approach to this product and essential to development of", + "cigarettes that demonstrated lower levels of toxicity on well-accepted toxicological tests. I was told", + "by my colleagues and superiors that there was an agreement with other tobacco manufacturers that", + "none would conduct biological research internally and that Philip Morris' biological research on the", + "health effects of cigarettes would be conducted by an overseas entity called the Institute for", + "Biological Research (\"INBIFO\") in Cologne, Germany.", + "I was also told that the industry had agreed that, within the United States, biological research,", + "normally an area of competitive significance not disclosed to competitors, would only be conducted", + "jointly by the industry under the control of TIRC/CTR. To my knowledge, such testing was", + "predominantly done on prototype or \"reference\" cigarettes, not on as-sold products. When any", + "-18-", + "3990178022", + "3990178022", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.127264, + 0.135925, + 0.6806, + 0.015327 + ], + [ + 0.127686, + 0.171231, + 0.741955, + 0.015179 + ], + [ + 0.127462, + 0.206592, + 0.713923, + 0.015467 + ], + [ + 0.126803, + 0.241541, + 0.759434, + 0.016215 + ], + [ + 0.126662, + 0.277446, + 0.735001, + 0.015466 + ], + [ + 0.126165, + 0.312656, + 0.699667, + 0.015354 + ], + [ + 0.125808, + 0.347902, + 0.707242, + 0.015396 + ], + [ + 0.125655, + 0.383011, + 0.746349, + 0.015832 + ], + [ + 0.125503, + 0.418413, + 0.751458, + 0.015512 + ], + [ + 0.125588, + 0.453626, + 0.716599, + 0.015425 + ], + [ + 0.125242, + 0.489306, + 0.172771, + 0.01455 + ], + [ + 0.17943, + 0.524485, + 0.687728, + 0.0154 + ], + [ + 0.125027, + 0.559408, + 0.754155, + 0.015373 + ], + [ + 0.124653, + 0.594819, + 0.74457, + 0.015578 + ], + [ + 0.124202, + 0.630086, + 0.756412, + 0.015381 + ], + [ + 0.124731, + 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Although I was hired to develop a less hazardous cigarette, I was never", + "provided with any reports which showed the results of this biological research. Since I left Philip", + "Morris, however, I have learned that research I considered necessary to development of safer", + "products was shared with Philip Morris' \"competitors.\" I was told by my colleagues at Philip", + "Morris that biological research had been conducted but that I was not permitted to see this research", + "or know the results, despite my position as Director of Applied Research. Although my co-workers", + "at Philip Morris would not disclose this research to me, it was disclosed to employees of Philip", + "Morris' \"competitors.\"", + "Based upon my personal knowledge and review of documents, the tobacco companies were", + "concerned that competition among them on health-related issues could result in liability in litigation", + "brought by individual smokers and might also prompt regulation by the FDA, which, well after the", + "eleventh hour, Philip Morris finally claims to agree with. Although the tobacco companies intended", + "cigarettes to deliver nicotine and thereby foster addiction, they concealed this information to avoid", + "regulation, in part because they knew their products were hazardous. By their agreement not to", + "conduct meaningful in-house biological research, the cigarette manufacturers effectively ensured", + "that none of their competitors would acknowledge the adverse effects of smoking or the", + "addictiveness of nicotine. The tobacco companies recognized that an admission of this sort would", + "result in efforts by the FDA to regulate nicotine as a drug. In the case of such regulation, any", + "manufacturer which was positioned to immediately provide research required by the FDA would", + "-19-", + "3990178023", + "3990178023", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.129506, + 0.134853, + 0.734284, + 0.015498 + ], + [ + 0.129107, + 0.170232, + 0.746488, + 0.015393 + ], + [ + 0.129199, + 0.205763, + 0.757201, + 0.015399 + ], + [ + 0.129256, + 0.241329, + 0.695482, + 0.015412 + ], + [ + 0.128814, + 0.276891, + 0.446055, + 0.014634 + ], + [ + 0.185652, + 0.312001, + 0.693341, + 0.014662 + ], + [ + 0.127945, + 0.347018, + 0.733816, + 0.015205 + ], + [ + 0.128225, + 0.382386, + 0.740702, + 0.015579 + ], + [ + 0.127941, + 0.417596, + 0.70582, + 0.015071 + ], + [ + 0.127652, + 0.45268, + 0.746217, + 0.015433 + ], + [ + 0.127408, + 0.48728, + 0.724614, + 0.015407 + ], + [ + 0.127699, + 0.522703, + 0.16014, + 0.016048 + ], + [ + 0.179326, + 0.576122, + 0.702793, + 0.015025 + ], + [ + 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Therefore, by their agreement", + "that they would not conduct in-house biological research, the tobacco companies ensured that none", + "of them would generate information that could provide a basis for FDA regulation, and ensured that,", + "should the FDA successfully assert regulatory authority, none would be positioned to gain a", + "competitive advantage from early submissions to the FDA.", + "I have reviewed numerous documents from tobacco manufacturers, including Philip Morris,", + "R. J. Reynolds, Brown & Williamson and B.A.T., Lorillard, Liggett, and from industry-supported", + "studies. Based on my review of these documents, and my experience and training, I conclude that", + "the manufacturers had a longstanding agreement not to publicly conduct meaningful in-house", + "biological research on as-marketed products. This \"gentlemen's agreement\" among manufacturers", + "had the effect of eliminating, or secreting, biological research that was necessary to improve the", + "safety of the product.", + "E. The tobacco manufacturers failed to use available technology to produce cigarettes", + "that demonstrated less toxicological activity and that were thus potentially less hazardous", + "Any claim by the tobacco companies that they have had a long standing and continuous goal", + "to eliminate from marketed products smoke components that are of concern to the scientific", + "community is false. It is only until very recently that Philip Morris has finally admitted that", + "cigarettes cause disease and are addictive. Moreover, Philip Morris now appears to finally admit-", + "that it is capable of making reduced risk cigarette products utilizing the same technology that I have-", + "been advocating for years.", + "Historically, the tobacco companies have gone to great lengths to conduct hundreds of", + "millions of dollars of confidential research on the relationship between smoking and health and on", + "-20-", + "3990178024", + "3990178024", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.127045, + 0.133575, + 0.739881, + 0.015031 + ], + [ + 0.127636, + 0.168987, + 0.746013, + 0.015547 + ], + [ + 0.127463, + 0.204421, + 0.70839, + 0.015979 + ], + [ + 0.127059, + 0.239907, + 0.761619, + 0.01547 + ], + [ + 0.127163, + 0.275511, + 0.347762, + 0.015454 + ], + [ + 0.179622, + 0.310273, + 0.708224, + 0.0158 + ], + [ + 0.126057, + 0.345898, + 0.722226, + 0.015448 + ], + [ + 0.126122, + 0.381394, + 0.756767, + 0.015175 + ], + [ + 0.125791, + 0.416735, + 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This research began in earnest in the 1950's and intensified in the 60's and", + "70's. As this research began to provide further evidence for disease causation and addiction, much", + "of it was stopped or moved to foreign shores where it could be effectively hidden. Numerous", + "technological innovations were available to the industry to reduce the harm from cigarettes but those", + "were not developed, not pursued or exploited.", + "The-cigarette manufacturing industry is a highly sophisticated industry with the ability to use", + "advanced product design technology to produce cigarettes that could, if desired, reduce tar and", + "maintain nicotine or reduce both tar and nicotine. The tobacco companies have collectively refused", + "to incorporate technology that would cause significant reductions in potent chemical toxic materials,", + "and often patented technologies that could be used in cigarettes to potentially reduce disease caused", + "by smoking without actually effectively using such technology. The technology to do so has been", + "available and improved over decades.", + "In my view, it is technologically feasible today to design a cigarette which would not cause", + "an increase in cancer, emphysema, asthma, heart failure or other smoking-related diseases. To my", + "knowledge, none of the manufacturers has done this, although Philip Morris investigated the", + "possibility in the early 1970's. During the course of this research many potential product concepts", + "were discovered that could have been used to potentially reduce the risk associated with smoking", + "but were not. The measures discussed above, in addition, could have been adopted and would have", + "affected the product users' awareness of the risks associated with the product.", + "Any of the tobacco companies could have developed a less harmful cigarette by, among other", + "things:", + ". Reducing the nitrosamines in cigarettes.", + "-21-", + "3990178025", + "3990178025", + "Source:https://www.industrydocuments.ucsf.edu/docs/htfv0184." + ] + }, + { + "bbox": [ + [ + 0.181784, + 0.131655, + 0.350127, + 0.015703 + ], + [ + 0.178926, + 0.167621, + 0.370969, + 0.015646 + ], + [ + 0.179931, + 0.203005, + 0.413753, + 0.016052 + ], + [ + 0.176763, + 0.23874, + 0.160771, + 0.015566 + ], + [ + 0.182708, + 0.274631, + 0.276745, + 0.015212 + ], + [ + 0.186521, + 0.310367, + 0.625411, + 0.015612 + ], + [ + 0.188451, + 0.345749, + 0.614407, + 0.015724 + ], + [ + 0.18976, + 0.382225, + 0.408878, + 0.015392 + ], + [ + 0.24146, + 0.41785, + 0.16038, + 0.01428 + ], + [ + 0.240903, + 0.453179, + 0.440916, + 0.015481 + ], + [ + 0.176736, + 0.487846, + 0.701131, + 0.015431 + ], + [ + 0.122601, + 0.523197, + 0.767769, + 0.015899 + ], + [ + 0.12166, + 0.559149, + 0.766286, + 0.014905 + ], + [ + 0.121173, + 0.594605, + 0.717561, + 0.015588 + ], + [ + 0.121554, + 0.629912, + 0.738924, + 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or removing nicotine altogether.", + "Some of the manufacturers have recently begun to claim that new products, such as Eclipse-", + "(R.J.Reynolds), Accord (PhilipMorris), and Omni (Liggett) none of which necessarily fall within-", + "the accepted definition of a \"cigarette\" reduce levels of some of these toxins delivered in cigarette-", + "smoke. However, the technologies to accomplish exactly these ends existed much earlier, but", + "efforts to incorporate them successfully into marketed products were never seriously undertaken.", + "I was personally involved in development of one method for removing from smoke virtually", + "all nitrosamines, generally recognized as one of the most carcinogenic agents, even in \"low tar\"", + "cigarettes, but never saw the result successfully marketed. Oxides of nitrogen can also be reduced", + "dramatically simply by working with tobacco farmers to reduce the use of nitrate fertilizers in-", + "tobacco. Neither the industry nor any individual tobacco company has ever set, or even suggested, a", + "standard for tobacco specific nitrosamines (TSNAs) in tobacco, or otherwise recommended or", + "established standards which would prevent purchase or use of tobacco high in TSNAs: I was also", + "-22-", + "3990178026", + "3990178026", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.126242, + 0.133715, + 0.731101, + 0.015173 + ], + [ + 0.126567, + 0.169072, + 0.630916, + 0.015526 + ], + [ + 0.18059, + 0.205281, + 0.685546, + 0.015094 + ], + [ + 0.127649, + 0.240466, + 0.759208, + 0.01531 + ], + [ + 0.126147, + 0.275924, + 0.7393, + 0.015228 + ], + [ + 0.125928, + 0.311418, + 0.752522, + 0.015257 + ], + [ + 0.125259, + 0.347052, + 0.747803, + 0.015121 + ], + [ + 0.171514, + 0.382053, + 0.688775, + 0.015759 + ], + [ + 0.1253, + 0.417404, + 0.767017, + 0.015531 + ], + [ + 0.125666, + 0.452835, + 0.71822, + 0.015414 + ], + [ + 0.124758, + 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manufacturers back in the", + "1970's which were not exploited by the industry. Some examples include: removal of nicotine from", + "tobacco; reduction or removal of radioactive materials such as polonium 210; and use of nicotine", + "analogues. Charcoal filters are another example of available technology which was not developed", + "for widespread commercial use in the U.S. market. Although, as early as 1964, the charcoal filter-", + "n-acknowledged physiological improvement, and is very effective at removing many toxic-", + "materials, the tobacco companies agreement among themselves to avoid competing on health issues", + "prevented them from reporting on or pursuing this benefit. Similarly, it is relatively simple to", + "screen for the presence of excess radioactive materials. Aldchyde levels could be decreased through", + "more caroful selection of sugar additives and by carbon filters. These methods for reducing", + "carcinogens were known to the industry; I am not aware of any evidence that they were-", + "implemented to move toward a safer cigarette. Even in those instances where the tobacco-", + "companies used available technologies, they did not perform product testing necessary to determine", + "whether or not there was a reduction in hazard. I have not seen, nor am I aware of any evidence that-", + "the manufacturers were producing a safer product. The current products such as Eclipse and-", + "Accord, and the now defunct Premier, are the first for which the manufacturers have provided", + "extensive biological data, but they still have not been compared to high tar, \"low tar,\" and other-", + "cigarettes by brand. It is only through biological testing with brand identification that consumers", + "can- truly understand whether one cigarette or smoking article is safer than another.", + "Many potentially significant technologies were patented by the industry. These patents", + "-23-", + "3990178027", + "3990178027", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv.0184" + ] + }, + { + "bbox": [ + [ + 0.126712, + 0.134154, + 0.757492, + 0.016007 + ], + [ + 0.126859, + 0.169986, + 0.752919, + 0.015512 + ], + [ + 0.125539, + 0.205146, + 0.759452, + 0.015757 + ], + [ + 0.125389, + 0.240274, + 0.738027, + 0.015592 + ], + [ + 0.1773, + 0.275705, + 0.695036, + 0.015966 + ], + [ + 0.124663, + 0.31108, + 0.733831, + 0.015693 + ], + [ + 0.124103, + 0.346519, + 0.755062, + 0.014791 + ], + [ + 0.12445, + 0.381151, + 0.145996, + 0.015207 + ], + [ + 0.238052, + 0.416492, + 0.645979, + 0.015598 + ], + [ + 0.238125, + 0.45226, + 0.186522, + 0.014772 + ], + [ + 0.238866, + 0.487386, + 0.577496, + 0.01488 + ], + [ + 0.237274, + 0.522339, + 0.616166, + 0.014907 + ], + [ + 0.23741, + 0.557672, + 0.100554, + 0.013538 + ], + [ + 0.237955, + 0.592679, + 0.612089, + 0.015907 + ], + [ + 0.237483, + 0.628426, + 0.611436, + 0.015243 + ], + [ + 0.237277, + 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As a further example, Philip Morris researcher Scott Osborne conceived of an", + "\"indirect cigarette in the early 1970's which, had Philip Morris pursued it, would have provided the", + "same central nervous system impact as the traditional cigarette but without all the harmful effects.", + "Additionally, in the area of gas phase delivery of toxie substances in cigarettes, the industry", + "had technology available to reduce these gases and failed to use it. Although the industry claims-", + "reductions in FTC delivery numbers as evidence of \"good faith' in reducing hazardous compounds,", + "they have failed to:", + "Investigate the levels to which the hazardous compounds must be reduced so that the", + "reduction is meaningful;", + "disclose the specific design changes that exacerbate differences between the", + "measured FTC levels and the levels of these compounds that the smoker actually-", + "receives; and", + "disclose that compounds that do not ge into the mainstream smoke to the smoker", + "end up in the side stream smoke to pose a risk to \"passive smokers\" and smokers", + "sitting in the side stream fumes when dilution or ventilation is the means for-", + "reduction of tar delivery. Industry researchers estimate that smokers obtain 16 times-", + "more side stream exposure than passive smokers yet the additional load of", + "earcinogens from side stream smoke is never disclosed to smokers.", + "Within Philip Morris, although much of the research was directed to development of", + "promising technologies, including some of the methods described above, that could potentially", + "produce a safer cigarette, none to my knowledge were ever pursued to the point of actually", + "-24-", + "3990178028", + "3990178028", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv.0184" + ] + }, + { + "bbox": [ + [ + 0.114048, + 0.130243, + 0.752944, + 0.015156 + ], + [ + 0.169626, + 0.16559, + 0.714685, + 0.015407 + ], + [ + 0.114234, + 0.201375, + 0.156294, + 0.015486 + ], + [ + 0.228779, + 0.23716, + 0.601355, + 0.015269 + ], + [ + 0.229262, + 0.272423, + 0.644191, + 0.015641 + ], + [ + 0.229585, + 0.308397, + 0.500391, + 0.015502 + ], + [ + 0.228534, + 0.343778, + 0.51456, 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This would allow informed choice among products.", + "Using well known brand names for products they deem to be safer.", + "Admitting, much earlier than 1999, that there is a causative link between smoking", + "and cancer, emphysema, and other diseases.", + "Providing data on the chemical composition of the mainstream and sidestream smoke", + "for all toxie or carcinogenie materials in smoke from conventional cigarettes, much-", + "as they have done for their novel products recently announced.", + "Working with FDA or other appropriate regulatory agencies to develop guidelines-", + "for the testing and publication of data on the biological effects of cigarette smoke.", + "Only after extensive litigation was initiated against the tobacco industry did it respond with-", + "products like Premier, Eclipse, and Accord. These products, as well as Philip Morris' denicotinized", + "product, Next, were and are marketed in such a manner that there is no public credibility that they", + "are, in fact, safer, and appear to be on the market solely to make a case for the continued sale of the", + "established products.", + "F.", + "The industry has facilitated failure of safer products by failing to use its", + "available resources and through the agreed upon restrictions on competition among", + "manufacturers", + "Research programs that showed promise were either shut down or never used. The general", + "-25-", + "3990178029", + "3990178029", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.122212, + 0.13116, + 0.736583, + 0.01546 + ], + [ + 0.120809, + 0.166732, + 0.763975, + 0.015397 + ], + [ + 0.121816, + 0.202397, + 0.738521, + 0.015192 + ], + [ + 0.121023, + 0.237704, + 0.63184, + 0.015347 + ], + [ + 0.176122, + 0.272966, + 0.697003, + 0.015695 + ], + [ + 0.121533, + 0.308582, + 0.764983, + 0.015323 + ], + [ + 0.121738, + 0.343999, + 0.699262, + 0.015617 + ], + [ + 0.120917, + 0.3799, + 0.762915, + 0.01494 + ], + [ + 0.116185, + 0.41491, + 0.713025, + 0.015469 + ], + [ + 0.17527, + 0.450427, + 0.705082, + 0.015357 + ], + [ + 0.120893, + 0.485604, + 0.738765, + 0.015564 + ], + [ + 0.120704, + 0.521294, + 0.732032, + 0.01569 + ], + [ + 0.120268, + 0.557029, + 0.742532, + 0.015241 + ], + [ + 0.120068, + 0.592463, + 0.742454, + 0.015364 + ], + [ + 0.119995, + 0.62737, + 0.737042, + 0.015296 + ], + [ + 0.11964, + 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As discussed above, the industry has available to it a vast knowledge", + "of flavoring devices which could be employed to develop a successful or \"acceptable\" taste.", + "Additionally, when a new brand is introduced, general acceptance is not the usual case. Advertising", + "and marketing are usually performed until the new brand is accepted if the attempt is serious.", + "The industry often defends its decision not to provide less hazardous products by contending", + "that they are not \"acceptable\" to consumers. For example, Philip Morris provides this excuse for", + "\"Next,\" a denicotinized cigarette that was virtually free of nitrosamines because the process that", + "removed the nicotine also removed the nitrosamines. Philip Morris had the capability to improve", + "the flavor of this product without adding nicotine, and so create a non-addictive cigarette. It also-", + "had the technology to re add nicotine but not nitrosamines after their removal, resulting in a", + "product nearly free of earcinogenie nitrosamines which still had the nicotine \"kick\". Philip Morris,", + "however, did neither of these, and knew the product would fail due to the lack of nicotine or other", + "flavors, especially since it never provided the public with toxicology information for the product", + "that could have made it more attractive to consumers.", + "Products such as Eclipse, Next, Premier and Accord, as well as other potentially safer-", + "products which might be developed, could be commercially successful if properly supported and", + "maintained. These products allegedly reduce harmful constituents, but the tobacco companies have", + "-26-", + "3990178030", + "3990178030", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.123735, + 0.132629, + 0.745202, + 0.015787 + ], + [ + 0.12352, + 0.16842, + 0.734128, + 0.015173 + ], + [ + 0.123334, + 0.203836, + 0.693058, + 0.015537 + ], + [ + 0.176459, + 0.239726, + 0.711441, + 0.01521 + ], + [ + 0.122236, + 0.27514, + 0.74429, + 0.015244 + ], + [ + 0.12244, + 0.30997, + 0.758366, + 0.015563 + ], + [ + 0.122375, + 0.344716, + 0.72961, + 0.015723 + ], + [ + 0.122551, + 0.380366, + 0.734971, + 0.015345 + ], + [ + 0.121977, + 0.415787, + 0.692484, + 0.015093 + ], + [ + 0.122596, + 0.451009, + 0.626597, + 0.014968 + ], + [ + 0.176546, + 0.486578, + 0.019384, + 0.012309 + ], + [ + 0.238392, + 0.486857, + 0.438568, + 0.014825 + ], + [ + 0.176085, + 0.521532, + 0.701446, + 0.014943 + ], + [ + 0.1217, + 0.556327, + 0.719244, + 0.015752 + ], + [ + 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The technology existed to add", + "nicotine such that the products had the same physiological impact without the carcinogens.", + "As another example, charcoal filters are recognized as very effective at reducing many of the", + "toxie materials in smoke, but they are rarely used. The tobacco companies generally claim this is", + "because they result in an unacceptable taste. The tobacco companies, however, have the ability and", + "resources to create additional \"flavor development\" programs to differentiate the products. The", + "additional cost of these programs is nominal; however, the tobacco companies' agreement not to", + "compete regarding issues regarding health or the relative harm of different cigarettes was a", + "disincentive, as any reduction could not then be marketed as a point of distinction.", + "G.", + "The tobacco companies efforts to mislead and confuse", + "With the dissolution of the Tobacco Institute and CTR, cigarette companies must now make", + "their own scientific claims rather than rely on paid research which they selected to confuse the", + "public and the scientific community. The industry continues to provide erroneous results to confuse", + "the public.", + "The testimony of industry scientists is intended to confuse the scientific issues without", + "providing any useful information on steps taken by industry members to effectively and realistically", + "produce a safer cigarette. In order to deal effectively with the problems caused by cigarettes, it is", + "first necessary for the tobacco companies to understand those problems.", + "The cigarette industry argued that it has been a leader in efforts to reduce or eliminate certain", + "smoke constituents. However, industry representatives did not admit that these constituents actually", + "damage smokers. They are essentially testifying that they have attempted to remove these", + "-27-", + "3990178031", + "3990178031", + "Source: https://www.industry.documents.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.126511, + 0.129717, + 0.470725, + 0.014917 + ], + [ + 0.180087, + 0.164743, + 0.691151, + 0.015524 + ], + [ + 0.125731, + 0.200363, + 0.717478, + 0.015392 + ], + [ + 0.126575, + 0.23591, + 0.739524, + 0.015377 + ], + [ + 0.125641, + 0.271056, + 0.757175, + 0.015336 + ], + [ + 0.125665, + 0.306316, + 0.75077, + 0.015254 + ], + [ + 0.126713, + 0.340968, + 0.757068, + 0.015769 + ], + [ + 0.125368, + 0.376707, + 0.749789, + 0.015483 + ], + [ + 0.125097, + 0.412118, + 0.753716, + 0.015406 + ], + [ + 0.124615, + 0.447625, + 0.750332, + 0.015681 + ], + [ + 0.125362, + 0.483145, + 0.609814, + 0.015244 + ], + [ + 0.177725, + 0.518271, + 0.701106, + 0.015688 + ], + [ + 0.123984, + 0.553442, + 0.761879, + 0.016103 + ], + [ + 0.123756, + 0.588843, + 0.761193, + 0.015718 + ], + [ + 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cigarette. Reynolds did-", + "not-even identify the \"low tar cigarette to which the new product is compared. Further, Reynolds'", + "analysis indicates there is no meaningful distinction in mutagenie effects between \"low tar\" and full-", + "flavor cigarettes, despite decades of contrary suggestions by the tobacco companies. Philip Morris-", + "has developed the Accord, but had never released meaningful testing data on other brands. None of", + "the tobacco companies had ever provided comparable data evidencing reductions in carcinogens or", + "other toxic compounds for other products over the years, or for current products.", + "The claim of general reduction in tar appears to be another attempt to confuse the public. In-", + "the 1960's and into the 1970's the tobacco industry sought to produce \"low tar cigarettes, promoting", + "the idea that reduction of tar as measured by the FTC produced a \"safer\" cigarette. The industry has-", + "not provided biological testing of the products against one another as a function of tar levels,", + "smoking habits, or-any other parameters.", + "The tobacco companies claim that many of the constituents and additives in cigarettes have", + "been found to be \"generally accepted as safe\" by the FDA. However, the FDA's determination of", + "safety is based on those substances being ingested, not burned and inhaled. None of the tobacco", + "companies has, to my knowledge, presented data on biologically safe inhalation levels for the", + "constituents of cigarette smoke, nor have they advised smokers that exposure via inhalation is much", + "more-acute than exposure by ingestion.-Rather the tobacco companies have, for years, sought to", + "-28-", + "3990178032", + "3990178032", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.124873, + 0.129593, + 0.743863, + 0.014998 + ], + [ + 0.12439, + 0.165594, + 0.697863, + 0.014812 + ], + [ + 0.12384, + 0.20083, + 0.71788, + 0.01535 + ], + [ + 0.123582, + 0.236371, + 0.728673, + 0.016 + ], + [ + 0.125929, + 0.27265, + 0.249727, + 0.015219 + ], + [ + 0.176834, + 0.308271, + 0.686464, + 0.015294 + ], + [ + 0.123551, + 0.343838, + 0.741762, + 0.015613 + ], + [ + 0.123224, + 0.376754, + 0.753767, + 0.018034 + ], + [ + 0.122845, + 0.411902, + 0.75645, + 0.018465 + ], + [ + 0.122802, + 0.450205, + 0.735115, + 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This is not supported by science.-Rather than providing truthful, accurate", + "information, the tobacco companies and their representatives have chosen to ignore, distort or-", + "suppress the truth concerning pharmacology or physiology to allow them to provide values that", + "seem-small to the general public.", + "For example, industry scientists have long argued that smokers are exposed to only \"small", + "amounts of toxic materials.\" One microgram per cigarette collected in the FTC smoking regimen", + "corresponds to 2.9 milligrams (mg) per cubic meter (m³. The Threshold Limit Values for workers", + "exposed to many of these toxic chemicals for many of these compounds is 0.1 mg/m³ and EPA safe", + "air quality standards are many times lower than that. For carcinogens, safe levels are even lower", + "and as little as 1 microgram/m³ is considered unacceptable.", + "The tobacco companies collectively report air pollution criteria and toxic measures for", + "inhalation only in terms of manograms per cigarette, rather than the concentration of nanograms/m³", + "of the smoke being inhaled. For conventional cigarettes, the tobacco companies do not say how", + "many nanograms of any particular toxic substance are contained in a cigarette. Five nanograms per", + "cigarette is equivalent to 14,300 nanograms/m³ of inhaled smoke or 14.3 micrograms/m³ for a", + "compound known to cause cancer in the lungs. Obviously this is still far above a safe level.", + "The industry further claims a reduction in CO yields. Workers' exposure to CO is limited to", + "29 mg/m³ and exposure limits for the general public is less than this. In an FTC smoking test this", + "would correspond to 10 micrograms of CO per cigarette or less. Values of CO are always larger in", + "realistic smoking tests than in the FTC test. Cigarettes are still so far above the safe exposure limit", + "that the claimed reductions are meaningless.", + "-29-", + "3990178033", + "3990178033", + "Source: ttps://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.174986, + 0.170909, + 0.690687, + 0.01516 + ], + [ + 0.115771, + 0.203376, + 0.707829, + 0.019056 + ], + [ + 0.115319, + 0.242668, + 0.765396, + 0.015918 + ], + [ + 0.120759, + 0.278496, + 0.45305, + 0.015325 + ], + [ + 0.558543, + 0.350212, + 0.160783, + 0.012015 + ], + [ + 0.612888, + 0.368093, + 0.052042, + 0.01397 + ], + [ + 0.611067, + 0.385914, + 0.053615, + 0.013823 + ], + [ + 0.611589, + 0.403653, + 0.052386, + 0.013937 + ], + [ + 0.611207, + 0.421331, + 0.053242, + 0.014136 + ], + [ + 0.606555, + 0.439084, + 0.062807, + 0.013379 + ], + [ + 0.606865, + 0.456491, + 0.062142, + 0.013673 + ], + [ + 0.606257, + 0.474396, + 0.062627, + 0.013348 + ], + [ + 0.606751, + 0.491755, + 0.061878, + 0.01346 + ], + [ + 0.606168, + 0.509184, + 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The basic process is predicated upon the fact that the", + "nicotine in tobacco is a soluble substance which can be \"washed\" away through the use of a solvent.", + "This technology is fully described in the following patents:", + "Great Britain Patents", + "17,024", + "20,347", + "23,528", + "26,939", + "345,249", + "351,779", + "754,772", + "934,007", + "959,190", + "Internal documents from Philip Morris evidences pursuit in 1955 of a Reduction of Nicotine", + "in Tobacco Project, identified as Project 2-012. (See Bates # 1001900597-98 and 1001900574-75).", + "This Project involved dipping tobacco in heated water followed by drying of the tobacco. The", + "percentage of nicotine removed was found to increase with increases in water temperature and", + "dipping time. With only a 10 minute dipping period, reductions of nicotine up to 95% were", + "realized.", + "-30-", + "3990178034", + "3990178034", + "H.", + "Nicotine Extraction", + "United States Patents", + "1,551,676", + "1,577,768", + "1,640,298", + "1,719,291", + "1,823,554", + "2,048,624", + "2,136,485", + "2,162,738", + "2,227,863", + "2,805,667", + "3,046,997", + "3,132,651", + "3,139,435", + "3,151,118", + "3,280,823", + "3,396,735", + "3,612,066", + "3,742,962", + "Source: ttps://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.190548, + 0.137077, + 0.657013, + 0.015705 + ], + [ + 0.13293, + 0.171995, + 0.673757, + 0.015749 + ], + [ + 0.133451, + 0.207402, + 0.750904, + 0.015199 + ], + [ + 0.132414, + 0.242924, + 0.729895, + 0.015266 + ], + [ + 0.132264, + 0.277627, + 0.701438, + 0.015168 + ], + [ + 0.131509, + 0.312949, + 0.736913, + 0.015527 + ], + [ + 0.131832, + 0.348092, + 0.712875, + 0.015308 + ], + [ + 0.131661, + 0.383142, + 0.756221, + 0.015141 + ], 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to be flat and tasteless.\" (See Bates #", + "1001900604-05). But established (addicted) smokers do not smoke for taste - they smoke to satisfy", + "their nicotine addiction. This is the real reason why Project 2-012 was discontinued. If taste was", + "the issue, it could have easily been added. The addictive nature of tobacco smoking was well", + "known, even before Project 2-012. In the December 19, 1942 edition of the Lancet, an article was", + "published entitled Tobacco Smoking and Nicotine. This study revealed that smokers preferred", + "injections of nicotine to a cigarette and that \"smokers show the same attitude to tobacco as addicts to", + "their drug. \"", + "By utilizing the solvent nicotine extraction method, which as previously stated has been", + "available since the early 20th century, reduction of cigarette nicotine delivery to 0.06 mg per", + "cigarette or less has been completely feasible long before Mr. Haglund was supposed to have started", + "smoking (late sixties/early seventies). It is my understanding that Dr. Joseph DiFranza will testify", + "that cigarettes with a nicotine delivery of 0.06 mg or less have insufficient nicotine to initiate or", + "sustain nicotine addiction on the basis of a study entitled Pharmacodynamic Effects of New De-", + "nicotinized Cigarettes, Nicotine & Tobacco Research (1999) 1, 357-364.", + "The beauty of the nicotine solvent extraction process is that based upon the number of", + "successive solvent treatments, and regardless of which process is used, or which tobacco, the", + "tobacco nicotine content can be reduced to next to nil if desired. The primary variables involved in", + "the process are the selection of the particular solvent extraction process which will determine the", + "initial percentage of nicotine removal during the first treatment, and the percentage of nicotine in the", + "untreated tobacco.", + "-31-", + "3990178035", + "3990178035", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.18655, + 0.134349, + 0.701079, + 0.015838 + ], + [ + 0.128804, + 0.170093, + 0.736999, + 0.015506 + ], + [ + 0.129136, + 0.205723, + 0.753361, + 0.015947 + ], + [ + 0.12912, + 0.24149, + 0.742533, + 0.015307 + ], + [ + 0.128579, + 0.27731, + 0.708196, + 0.015238 + ], + [ + 0.128099, + 0.312307, + 0.712287, + 0.01527 + ], + [ + 0.128144, + 0.347359, + 0.760235, + 0.016092 + ], + [ + 0.12777, + 0.382978, + 0.763268, + 0.016153 + ], + [ + 0.12801, + 0.418699, + 0.767167, + 0.015475 + ], + [ + 0.12765, + 0.453937, + 0.74853, + 0.015867 + ], + [ + 0.128139, + 0.489609, + 0.764743, + 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Using", + "tobacco with 2% nicotine, the entire cigarette would have 15 mg of nicotine. If you use the 95%", + "extraction figure which was documented in Project 2-012, 95% of 15 mg of nicotine leaves .75 mg", + "of nicotine in the entire cigarette. A second extraction (95% of 0.75 mg) would leave .037 mg of", + "nicotine in the entire cigarette. When you smoke a cigarette you generally get 10-20% of the", + "nicotine that is there. So, even with high nicotine tobacco in a Marlboro type cigarette which", + "contains about 20 mg of nicotine, you only get 1.5 to 2.5 mg. The reason for this is that most of the", + "nicotine goes to side stream between puffs. The FTC smoking conditions usually show the nicotine", + "as well below 2.0 mg even though the tobacco has 20 mg or more. More aggressive regimes can get", + "you close to the 20% range. However, under the most extreme compensation conditions, it would", + "be impossible to get any more than half the nicotine. Thus, 50% of .037 mg of nicotine in the entire", + "cigarette would result in a cigarette with a maximum nicotine delivery of .019 mg.", + "In the above example, the nicotine content could be reduced even further through additional", + "extractions. However, to minimize the number of extractions, tobacco with a much lower nicotine", + "content to start with could be acquired. For example, if you start with tobacco that contains .3%", + "nicotine¹, the following analysis would apply. If the cigarette has 750 mg of tobacco and it has .3%", + "nicotine, then it has 2.25 mg of nicotine in the entire cigarette. If you remove 95% of it, you are left", + "with 112 mg in the entire cigarette, and with a 50% delivery, you get .056 mg of nicotine.", + "The feasibility of reducing nicotine in cigarettes below addiction threshold through the use", + "of the solvent extraction process was experimentally demonstrated in the previously identified study", + "1", + "Selection of tobacco plants with .3% nicotine contenthas always been commercially possible. Moreover, naturally", + "occurring tobacco plants containing zero percent of nicotine could have been identified. I have grown such tobacco in", + "my own laboratory. There is no reason why such naturally occurring strains of tobacco plants could not have been", + "identified and propagated decades ago.", + "-32-", + "3990178036", + "3990178036", + "Source: https://www.industrydocuments,ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.130648, + 0.135486, + 0.743897, + 0.015664 + ], + [ + 0.129887, + 0.171368, + 0.693928, + 0.015573 + ], + [ + 0.130456, + 0.206924, + 0.756744, + 0.015752 + ], + [ + 0.129963, + 0.242505, + 0.074609, + 0.012377 + ], + [ + 0.186869, + 0.278133, + 0.673758, + 0.0157 + ], + [ + 0.129284, + 0.313767, + 0.627227, + 0.016244 + ], + [ + 0.491612, + 0.933626, + 0.033564, + 0.011532 + ], + [ + 0.063786, + 0.962562, + 0.090864, + 0.010655 + ], + [ + 0.018332, + 0.974951, + 0.135183, + 0.012945 + ], + [ + 0.226412, + 0.980998, + 0.545202, + 0.016328 + ] + ], + "poly": [ + [ + { + "X": 0.130648, + "Y": 0.135486 + }, + { + "X": 0.874546, + "Y": 0.135486 + }, + { + "X": 0.874546, + "Y": 0.15115 + }, + { + "X": 0.130648, + "Y": 0.15115 + } + ], + [ + { + "X": 0.129887, + "Y": 0.171368 + }, + { + "X": 0.823815, + "Y": 0.171368 + }, + { + "X": 0.823815, + "Y": 0.186941 + }, + { + "X": 0.129887, + "Y": 0.186941 + } + ], + [ + { + "X": 0.130456, + "Y": 0.206924 + }, + { + "X": 0.8872, + "Y": 0.206924 + }, + { + "X": 0.8872, + "Y": 0.222677 + }, + { + "X": 0.130456, + "Y": 0.222677 + } + ], + [ + { + "X": 0.129963, + "Y": 0.242505 + }, + { + "X": 0.204572, + "Y": 0.242505 + }, + { + "X": 0.204572, + "Y": 0.254882 + }, + { + "X": 0.129963, + "Y": 0.254882 + } + ], + [ + { + "X": 0.186869, + "Y": 0.278133 + }, + { + "X": 0.860626, + "Y": 0.278133 + }, + { + "X": 0.860626, + "Y": 0.293833 + }, + { + "X": 0.186869, + "Y": 0.293833 + } + ], + [ + { + "X": 0.129284, + "Y": 0.313767 + }, + { + "X": 0.756511, + "Y": 0.313767 + }, + { + "X": 0.756511, + "Y": 0.330011 + }, + { + "X": 0.129284, + "Y": 0.330011 + } + ], + [ + { + "X": 0.491612, + "Y": 0.933626 + }, + { + "X": 0.525176, + "Y": 0.933626 + }, + { + "X": 0.525176, + "Y": 0.945158 + }, + { + "X": 0.491612, + "Y": 0.945158 + } + ], + [ + { + "X": 0.063786, + "Y": 0.962562 + }, + { + "X": 0.154651, + "Y": 0.962562 + }, + { + "X": 0.154651, + "Y": 0.973217 + }, + { + "X": 0.063786, + "Y": 0.973217 + } + ], + [ + { + "X": 0.018332, + "Y": 0.974951 + }, + { + "X": 0.153515, + "Y": 0.974951 + }, + { + "X": 0.153515, + "Y": 0.987895 + }, + { + "X": 0.018332, + "Y": 0.987895 + } + ], + [ + { + "X": 0.226412, + "Y": 0.980998 + }, + { + "X": 0.771614, + "Y": 0.980998 + }, + { + "X": 0.771614, + "Y": 0.997326 + }, + { + "X": 0.226412, + "Y": 0.997326 + } + ] + ], + "score": [ + 0.9933, + 0.9987, + 0.9989, + 0.9979, + 0.9987, + 0.9977, + 0.9935, + 0.9867, + 0.9843, + 0.7269 + ], + "text": [ + "entitled Pharmacodynamic Effects of New De-nicotinized Cigarettes. In that study, \"nicotine was", + "removed from the tobacco of the de-nicotinized cigarettes with a mild alkaline (ammonium", + "solution) wash. The tobacco was steamed, air-dried and the final pH was adjusted with a citric acid", + "solution.\"", + "The above described process for de-nicotinizing cigarettes below the addiction threshold", + "level was available to Philip Morris before Mr. Haglund was born (July 22, 1948).", + "-33-", + "3990178037", + "3990178037", + "Source: :ttps://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + }, + { + "bbox": [ + [ + 0.185588, + 0.171848, + 0.050775, + 0.012196 + ], + [ + 0.592882, + 0.189754, + 0.195037, + 0.014229 + ], + [ + 0.495509, + 0.934694, + 0.033121, + 0.011855 + ], + [ + 0.062213, + 0.962749, + 0.090991, + 0.010521 + ], + [ + 0.01612, + 0.974981, + 0.135645, + 0.012891 + ], + [ + 0.225603, + 0.980927, + 0.549222, + 0.016765 + ] + ], + "poly": [ + [ + { + "X": 0.185588, + "Y": 0.171848 + }, + { + "X": 0.236363, + "Y": 0.171848 + }, + { + "X": 0.236363, + "Y": 0.184043 + }, + { + "X": 0.185588, + "Y": 0.184043 + } + ], + [ + { + "X": 0.592882, + "Y": 0.189754 + }, + { + "X": 0.78792, + "Y": 0.189754 + }, + { + "X": 0.78792, + "Y": 0.203983 + }, + { + "X": 0.592882, + "Y": 0.203983 + } + ], + [ + { + "X": 0.495509, + "Y": 0.934694 + }, + { + "X": 0.52863, + "Y": 0.934694 + }, + { + "X": 0.52863, + "Y": 0.946549 + }, + { + "X": 0.495509, + "Y": 0.946549 + } + ], + [ + { + "X": 0.062213, + "Y": 0.962749 + }, + { + "X": 0.153204, + "Y": 0.962749 + }, + { + "X": 0.153204, + "Y": 0.97327 + }, + { + "X": 0.062213, + "Y": 0.97327 + } + ], + [ + { + "X": 0.01612, + "Y": 0.974981 + }, + { + "X": 0.151766, + "Y": 0.974981 + }, + { + "X": 0.151766, + "Y": 0.987871 + }, + { + "X": 0.01612, + "Y": 0.987871 + } + ], + [ + { + "X": 0.225603, + "Y": 0.980927 + }, + { + "X": 0.774825, + "Y": 0.980927 + }, + { + "X": 0.774825, + "Y": 0.997692 + }, + { + "X": 0.225603, + "Y": 0.997692 + } + ] + ], + "score": [ + 0.9988, + 0.993, + 0.9954, + 0.9815, + 0.9837, + 0.9394 + ], + "text": [ + "Dated:", + "William A. Farone, Ph.D.", + "-34-", + "3990178038", + "3990178038", + "Source: https://www.industrydocuments.ucsf.edu/docs/htfv0184" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004275.json b/doc_00004275.json new file mode 100644 index 0000000000000000000000000000000000000000..6b35449f18ff910b4c1ac765257ca13567407694 --- /dev/null +++ b/doc_00004275.json @@ -0,0 +1,1184 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.712068, + 0.244652, + 0.078719, + 0.00658 + ], + [ + 0.224727, + 0.402963, + 0.521255, + 0.097694 + ], + [ + 0.252101, + 0.505862, + 0.464345, + 0.054028 + ], + [ + 0.615924, + 0.578174, + 0.160924, + 0.008799 + ], + [ + 0.215207, + 0.592542, + 0.148682, + 0.014114 + ], + [ + 0.215078, + 0.60674, + 0.147528, + 0.01217 + ], + [ + 0.399335, + 0.612617, + 0.164225, + 0.013054 + ], + [ + 0.399123, + 0.627587, + 0.231536, + 0.014413 + ], + [ + 0.665333, + 0.685561, + 0.093645, + 0.007816 + ], + [ + 0.309465, + 0.848225, + 0.013136, + 0.007542 + ], + [ + 0.196141, + 0.859528, 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J. Ingenito, Ph.D.", + "Dear Doctor Hirose:", + "You have already been informed of our gratitude", + "for the cogent evaluation you provided of the above cited", + "application.", + "As a token of our appreciation, we take pleasure", + "in enclosing an honorarium of $50.00.", + "Sincerely,", + "/", + "W. T. Hoyt", + "Executive Vice President", + "WTH:ek", + "encl.", + "50114117" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004277.json b/doc_00004277.json new file mode 100644 index 0000000000000000000000000000000000000000..49ab68361b5338b4b06a17eabb22fe910c36c0c7 --- /dev/null +++ b/doc_00004277.json @@ -0,0 +1,1532 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.729701, + 0.094177, + 0.166911, + 0.009937 + ], + [ + 0.113655, + 0.289481, + 0.53532, + 0.013585 + ], + [ + 0.763256, + 0.29093, + 0.103245, + 0.012587 + ], + [ + 0.763338, + 0.304931, + 0.121077, + 0.012486 + ], + [ + 0.1646, + 0.317652, + 0.660148, + 0.011175 + ], + [ + 0.143921, + 0.358469, + 0.74207, + 0.013987 + ], + [ + 0.104205, + 0.372752, + 0.765067, + 0.013018 + ], + [ + 0.146042, + 0.399909, + 0.738993, + 0.012933 + ], + [ + 0.102927, + 0.413195, + 0.793211, + 0.013211 + ], + [ + 0.102883, + 0.426731, + 0.474901, + 0.010906 + ], + [ + 0.146882, + 0.4406, + 0.738757, + 0.013675 + ], + [ + 0.103898, + 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The", + "article will require careful study and we will be analyzing it. We have a few", + "observations based on our initial review of it.", + "\"The study says that certain data `suggest that a certain gene, known as", + "P53, is a preferential target for DNA-damaging agents. On the one hand, this", + "study appears to suggest that benzo (a) pyrene was involved, but also raises the", + "possibility that any number of substances could be involved for this damage.", + "\"The study did not compare results in smokers with those in non-smokers", + "it is, therefore, impossible to tell whether these changes are related to", + "smoking.", + "Benzo (a) pyrene is everywhere. It is in air, soil and produced by the", + "combustion of any kind of organic matter. For example, it is produced by", + "backyard barbecues and the exhaust of automobiles and trucks.", + "The Surgeon General has reported that the levels of benzo (a) pyrene in", + "tobacco smoke are well below its threshold as a carcinogen in studies of", + "laboratory animals.", + "'The study limits the conclusions severely by saying that their results", + "Bloomberg-all rights reserved. Frankfurt:69-920410 Hong Kong:2-521-3000 London:171-330-7500 New", + "Prunceten:509-279-300 Singapore:226-3000 Sydney:2-777-9600 Tokyo:3-3201-9900 Washington", + "3270-292-14 13-0cc-75", + "Source: https://www.industrydocuments.ucsf.edu/docs/gqjg0066" + ] + }, + { + "bbox": [ + [ + 0.117831, + 0.300104, + 0.535007, + 0.013913 + ], + [ + 0.767193, + 0.30208, + 0.103535, + 0.012757 + ], + [ + 0.76773, + 0.316487, + 0.120805, + 0.012684 + ], + [ + 0.107656, + 0.328651, + 0.787723, + 0.013698 + ], + [ + 0.107112, + 0.342002, + 0.693276, + 0.013975 + ], + [ + 0.106837, + 0.3703, + 0.469201, + 0.012322 + ], + [ + 0.150751, + 0.384143, + 0.021967, + 0.009528 + ], + [ + 0.47593, + 0.383574, + 0.079329, + 0.011612 + ], + [ + 0.14833, + 0.396957, + 0.666451, + 0.01447 + ], + [ + 0.113629, + 0.411217, + 0.12743, + 0.012096 + ], + [ + 0.10727, + 0.438326, + 0.438934, + 0.013557 + ], + [ + 0.107065, + 0.452036, + 0.134256, + 0.013262 + ], + [ + 0.108132, + 0.46612, + 0.123084, + 0.010343 + ], + [ + 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Statements that go further do not come from the study,", + "but are editorial comments made by others pursuing their own agenda.", + "SOURCE Brown & Williamson Tobacco Corporation", + "-0-", + "10/18/96", + "/CONTACT: Tom Fitzgerald, Brown & Williamson Tobacco Corporation,", + "502-568-7468/", + "CO: Brown & Williamson Tobacco Corporation", + "ST: Kentucky", + "IN: TOB HEA", + "SU:", + "-0- - (PRN) Oct/18/96", + "13:40", + "EOS", + "(PRN)", + "Oct/18/96", + "13:40", + "86", + "- -0- - (PRN) Oct/18/96 13:55", + "Blcomberg-all rights reserved. Frankfure:59-920410 Hong Kong:2-521-3000 London : 171-330-7500 New York:212-303-2000", + "Princecen:609-279-3000", + "Singapore:226-3000", + "Sydney 2-777-9600", + "Tokyo 3-3201-8900", + "Washington DC:202-434-180", + "3270-292-14 13-Oct-36 14:03:07", + "Source: https://www.industrydocuments.ucsf.edu/docs/gqjg0066" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004278.json b/doc_00004278.json new file mode 100644 index 0000000000000000000000000000000000000000..d972f9acdfdad2fd441f3242641a1b1b1e863e98 --- /dev/null +++ b/doc_00004278.json @@ -0,0 +1,4516 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.190218, + 0.035301, + 0.192373, + 0.022019 + ], + [ + 0.189864, + 0.060033, + 0.194118, + 0.017049 + ], + [ + 0.480784, + 0.130684, + 0.066649, + 0.012039 + ], + [ + 0.117644, + 0.164816, + 0.136339, + 0.013889 + ], + [ + 0.117698, + 0.198744, + 0.190576, + 0.014748 + ], + [ + 0.117556, + 0.216284, + 0.32447, + 0.014731 + ], + [ + 0.117399, + 0.23338, + 0.171925, + 0.011601 + ], 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0.8927, + 0.886, + 0.9444 + ], + "text": [ + "Mallinckrodt", + "Pharmaceuticals", + "CBE-30", + "October 28, 2016", + "Office of Generic Drugs", + "Center for Drug Evaluation and Research", + "Metro Park North VII", + "7620 Standish Place", + "Rockville, MD 20855", + "RE:", + "ANDA 040409 for Hydrocodone Bitartrate and Acetaminophen Tablets USP, 5mg/325mg", + "Dear Sir or Madam:", + "Pursuant to 21 CFR $314.70 and Guidance for Industry: Changes to an Approved NDA or ANDA,", + "Mallinckrodt submits this CBE-30 supplement to propose the addition of bottles of 20, 30, 60, 90,", + "and 120 tablets. Per Guidance for Industry: Changes to an Approved NDA or ANDA, a change in", + "the number of units (e.g., tablets, capsules) or labeled amount (e.g., grams, milliliters) of a nonsterile", + "drug product in a unit-of-use container may be reported in a CBE-30 supplement. Please see the", + "Executive Summary provided in this section for details.", + "This submission (sequence 0037) is submitted in electronic format via the Electronic Submissions", + "Gateway (~115 MB) and certified to be free from virus infection using Trend Micro OfficeScan", + "v10.6.2497. The technical point of contact for this submission is Jeremy Grise, who may be", + "contacted by telephone at (314) 654-8259 or by e-mail atjeremy.grise.@mallinckrodt.com.", + "Should you have any questions regarding the content of this submission, or need additional", + "information, please contact me by phone at (314)-654-318701 by email at", + "paula.ruch@mallinckrodt.com", + "Sincerely,", + "Digitally signed by Paula Ruch", + "Paula Ruch", + "DN cn=Paula Ruch, o=Mallinckrodt, ou=Regulatory Affairs,", + "em ail=paula.ruch@mallinakrodt.com,c=US", + "Reasen: attest tothe accuracy and integrity of this document", + "Date: 2016. 10.28 10:25:33 -05'00", + "Paula Ruch", + "Senior Regulatory Affairs Product Specialist", + "675 McDonnell Blvd.", + "Hazelwood, MO 63042", + "Fax: (314)654-6496", + "Mallinckrodt Inc. 675 McDonnell Boulevard Hazelwood, MO 63042 ° 314.654.2000 T ° www.mallinckrodt.com", + "Source: https://www.industrydocuments.ucsf.edu/docs/hrfj0239 MNKOI 0002413662" + ] + }, + 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The 100-count bottles currently employ a non-child-resistant closure, however, the new proposed", + "counts may be sent home with patients, therefore, a child-resistant closure is proposed for these counts.", + "Included in Section 3.2.P.7 are a drawing, specification, release form, and technical data sheets for resins, colorants, and seal for the", + "proposed child-resistant closure (see table below for data sheets). In addition, USP <671> test results are provided for the currently", + "approved bottle P11009 and proposed closure P33813.", + "The following resins, colorants, seal, etc. are proposed for closure P33813. Some of the subcomponents (resin, seal) are common", + "to", + "currently approved packaging components; therefore the supporting technical documentation is not provided again in this submission;", + "in these cases, a link is provided to the sequence where this information was previously provided.", + "Table 1: Subcomponents of Proposed Closure P33813", + "Subcomponent", + "Name", + "Supporting", + "Supporting", + "Supporting", + "Document- ANDA", + "Document- ANDA", + "Document- ANDA", + "040409", + "040405", + "040400", + "Resin", + "Braskem FT120WV PP", + "Datasheet (sequence", + "Datasheet (sequence", + "Datasheet (sequence", + "0025 \"P35308 Braskem", + "0022 \"P35308 Closure-", + "0024 \"P35308 Closure-", + "Resin Tech Doc\")", + "Tech packet for", + "Tech packet for", + "Braskem Resin", + "Braskem Update\")", + "Update\")", + "Alternate Resin", + "Phillips 66 CH120LN", + "Datasheet", + "Datasheet", + "Datasheet", + "PP", + "Colorant", + "PolyOne ONCOLOR", + "Datasheet", + 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colorants, and seal/liner utilized in proposed closure P33813 are outlined below.", + "Letters of Authorization that have not previously been submitted in the ANDAs are provided in the current sequences", + "in", + "Section", + "1.4.1.", + "Hyperlinks are provided to the Letters of Authorization that have been provided in previous sequences.", + "Table 2: Letters of Authorization for Proposed Closure P33813", + "Letter of", + "Component/Subcomponent", + "Name", + "Authorization-ANDA", + "040409", + "Closure", + "38-400 Argus-Loc", + "DMF 4837", + "White 8S9W Closure", + "Resin", + "Braskem FT120WV PP", + "DMF 1584 (sequence", + "0025)", + "Phillips 66 CH120LN", + "Alternate Resin", + "DMF 19969", + "PP", + "Colorant", + "PolyOne", + "DMF 20467", + "CC00022680DR", + "Seal and Liner", + "Foilseal M-1", + "DMF 4544 (sequence", + "0017)", + "Mallinckrodt has packaged one lot each of 5mg/325, 7.5/325, and 10mg/325mg Hydrocodone Bitartrate and Acetaminophen Tablets", + "USP into 20 count and 120 count bottles to demonstrate stability of the drug product in the new proposed packaging configurations.", + "The 20, 30, 60, 90, and 120 count bottles all employ the same bottle and closure, therefore the 20 count and 120 count bottles may", + "used to bracket the 30, 60, and 90 count bottles, as they represent the extremes of the bracket; per ICH Q3D, bracketing can be applied", + "to studies of the same container closure system where either the container size or fill vary while the other remains constant.", + "Source: https://www.industrydocuments.ucsf.edu/docs/hrfj0239", + "0018 \"Technical Data", + "for P35309\")", + "Letter of", + "Letter of", + "Authorization -ANDA", + "Authorization -ANDA", + "040405", + "040400", + "DMF 4837", + "DMF 4837", + "DMF 1584 (sequence", + "DMF 1584 (sequence", + "0022)", + "0024)", + "DMF 19969", + "DMF 19969", + "DMF 20467", + "DMF 20467", + "DMF 4544 (previously", + "DMF 4544 (sequence", + "submitted in paper;", + "0016)", + "included in electronic", + "format in this sequence)", + "be", + "Please", + "MNKOI 0002413664" + ] + }, + { + "bbox": [ + [ + 0.090635, + 0.117915, + 0.816026, + 0.019618 + ], + [ + 0.090545, + 0.143351, + 0.390101, + 0.019601 + ], + [ + 0.090897, + 0.185131, + 0.795109, + 0.019145 + ], + [ + 0.091903, + 0.21043, + 0.754339, + 0.019176 + ], + [ + 0.090623, + 0.23529, + 0.774987, + 0.019626 + ], + [ + 0.090805, + 0.261051, + 0.766096, + 0.019396 + ], + [ + 0.091089, + 0.286581, + 0.493428, + 0.018969 + ], + [ + 0.286755, + 0.976076, + 0.42536, + 0.020454 + ], + [ + 0.860213, + 0.981208, + 0.114981, + 0.013782 + ] + ], + "poly": [ + [ + { + "X": 0.090635, + "Y": 0.117915 + }, + { + "X": 0.906661, + "Y": 0.117915 + }, + { + "X": 0.906661, + "Y": 0.137533 + }, + { + "X": 0.090635, + "Y": 0.137533 + } + ], + [ + { + "X": 0.090545, + "Y": 0.143351 + }, + { + "X": 0.480646, + "Y": 0.143351 + }, + { + "X": 0.480646, + "Y": 0.162952 + }, + { + "X": 0.090545, + "Y": 0.162952 + } + ], + [ + { + "X": 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The Certificates of Compliance for the bottle", + "(P11009) and closure (P33813) utilized in the demonstration batch are provided in Section 3.2.P.7. Three months of passing", + "accelerated and controlled room temperature stability data on the 20 and 120 count bottles is provided in Section 3.2.P.8.3. The", + "revised stability protocol is provided in Section 3.2.P.8.2 and blank commercial packaging records for the proposed counts are", + "provided in Section 3.2.P.3.3 (20 count, 30 count, 60 count, 90 count, 120 count).", + "Source: https://www.industrydocuments.ucsf.edu/docs/hrfj0239", + "MNKOI 0002413665" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004279.json b/doc_00004279.json new file mode 100644 index 0000000000000000000000000000000000000000..2fb50c6f46d15262b0fe8f83feff08932891071e --- /dev/null +++ b/doc_00004279.json @@ -0,0 +1,898 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.15919, + 0.082969, + 0.069504, + 0.016964 + ], + [ + 0.298551, + 0.083374, + 0.585137, + 0.033222 + ], + [ + 0.29409, + 0.117971, + 0.532019, + 0.013686 + ], + [ + 0.067911, + 0.169191, + 0.247136, + 0.01123 + ], + [ + 0.099857, + 0.182375, + 0.183256, + 0.010353 + ], + [ + 0.587049, + 0.184428, + 0.183085, + 0.010241 + ], + [ + 0.073434, + 0.194756, + 0.235138, + 0.011106 + ], + [ + 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WHEELING, ILLINOIS 60090 (TELEPHONE) (312) 541-8660", + "UNITED STATES TOBACCO COMPANY", + "100 WEST PUTNAM AVENUE", + "CONTACT: Anne Fornoro", + "GPEENINICH, CONNECTICUT 06830", + "(203) 661-1100", + "203i661-1100", + "FABI'S SEASON TAKES A TURN FOR THE BETTER", + "GREENWICH, Conn. June 20 - Teo Fabi is hoping his season has finally", + "taken a turn for the better as he heads for the U.S. Grand Prix at the", + "Meadowlands July 1.", + "Fabi's third place finish in the Forsythe Racing Skoal Bandit at Port-", + "land on Father's Day stands as his best to date this season. But it didn't", + "come easily.", + "After an engine fire from an oil leak knocked out his primary car in", + "practice Thursday, Fabi resorted to his back-up car which he qualified in", + "the fourth row beside Bobby Rahal.", + "Fabi got off to a slow start, fading back as far as 11th before he", + "began picking up the pace. However, the smooth-driving native of Milan,", + "Italy drove conservatively as he watched frontrunners fall by the wayside", + "in the grueling heat. Two clean pit stops and a heads-up strategy saw", + "Fabi follow first-time winner Al Unser Jr. and runner-up Derek Daly to", + "the checkered flag.", + "While Fabi's peers can take a week off before the Meadowlands, the", + "29-year-old driver will be honing his road-racing skills in Formula One's", + "Detroit Grand Prix set for June 24.", + "With teammate Nelson Piquet winning both pole and race in the June 17", + "Canadian Grand Prix for his first finish of the year, Fabi's fortunes are", + "looking better in that arena also.", + "--30--", + "3408271", + "Source: https://www.industrydocuments.ucsf.edu/docs/fsvy0030" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004280.json b/doc_00004280.json new file mode 100644 index 0000000000000000000000000000000000000000..4420cfbc6fdd21e04614f064184ae5704ccd8ab0 --- /dev/null +++ b/doc_00004280.json @@ -0,0 +1,2572 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.719399, + 0.023898, + 0.050946, + 0.013395 + ], + [ + 0.727562, + 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J. Reynolds is currently advertising that it is placing more tobacco into its top selling Doral", + "brand, while not changing the size or taste. Shipments of the new Doral, with the advertising", + "slogan \"Now Packed Tighter to Burn Slower' \"TM and \"They're jampacked,\" began in February.", + "The company claims the additional tobacco should add about one puff per cigarette and put Doral", + "on the same level as premium brands. Doral held the second-best market share among all", + "cigarettes sold domestically in 1999, behind Philip Morris' premium brand Marlboro, and is the", + "country's top-selling discount cigarette.", + "Product from January and February 2000 production was tested to determine if the new Doral", + "contains more tobacco and/or delivers an additional puff when machine smoked at the FTC", + "conditions of 35cc puff volume, 2 sec puff duration, and 60 seconds between puffs. The brands", + "tested were Doral FF KS Box, Doral FF KS SP, Doral Lts 100 SP and Doral Ultra Lts 100 SP.", + "Data were compared to the 1999 average.", + "Summary of Trends Identified:", + "Average cigarette tobacco weight increases of approximately 12 to 26 mg were seen in the", + "four tested brands, compared to the 1999 average.", + "Doral FF KS SP and Doral Ultra Lts 100 SP puff counts increased nearly a full puff; Doral", + "FF KS Box showed a decrease; and Doral Lts 100 SP showed minimal change.", + "It appears that lower cigarette paper permeability and higher filter ventilation, together with", + "modest tobacco weight increases, are being used to adjust puff count. Paper permeability", + "was 4-5 Coresta Units lower on the four brands tested. Ventilation was 4-5 percent higher for", + "the brands with the exception of Doral FF KS Box.", + "***", + "The following spreadsheet is a summary of delivery and physical attribute data for these four", + "brands. Tobacco weight, corrected to 13% OV, percent filter ventilation, and cigarette paper", + "permeability are highlighted. These appear to be the cigarette design factors most changed in the", + "January and February 2000 product.", + "PM3000469761", + "Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/ffpv0150" + ] + }, + { + "bbox": [ + [ + 0.726756, + 0.059207, + 0.091869, + 0.009908 + ], + [ + 0.758407, + 0.07062, + 0.060571, + 0.007914 + ], + [ + 0.12093, + 0.108202, + 0.660015, + 0.012066 + ], + [ + 0.121085, + 0.124494, + 0.654625, + 0.014759 + ], + [ + 0.121685, + 0.141114, + 0.630771, + 0.014104 + ], + [ + 0.121945, + 0.157452, + 0.671987, + 0.013697 + ], + [ + 0.12175, + 0.173088, + 0.629562, + 0.014068 + ], + [ + 0.121912, + 0.189794, + 0.140599, + 0.013579 + ], + [ + 0.121481, + 0.21729, + 0.684188, + 0.013756 + ], + [ + 0.122137, + 0.233485, + 0.617046, + 0.01425 + ], + [ + 0.122307, + 0.261471, + 0.655388, + 0.014493 + ], + [ + 0.121615, + 0.277934, + 0.524016, + 0.014019 + ], + [ + 0.121907, + 0.305648, + 0.299555, + 0.011288 + ], + [ + 0.122105, + 0.400052, + 0.083873, + 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It increased in the January product", + "(consistent with the other products) but decreased in the February product. This brand had an", + "average puff count decrease in February. This lack of consistency will be monitored in", + "subsequent months.", + "The amounts of expanded stem and/or filler composition displayed the normal fluctuations seen", + "in this brand family. Rod firmness showed an increasing trend in several of the brands.", + "Also attached are separate data sheets for each brand, comparing 1999 averages from the CI", + "Program to the January and February 2000 production special test results.", + "The brands will continue to be monitored.", + "Attachments", + "Distribution:", + "R. Anise (NYO)", + "D. Milby (OC)", + "M. Arwady (NYO)", + "M. Mobrem (OC)", + "M. Barrington (NYO)", + "J. Nelson (OC)", + "D. Beran (NYO)", + "K. Newman (OC)", + "J. Bonhomme (NYO)", + "U. Nyffeler (OC)", + "N. Brennan Lund (NYO)", + "A. Padoan (NYO)", + "H. Burnley (OC)", + "L. Peuckert (Ryebrook)", + "L. Chambers (OC)", + "K. Podraza (RD&E)", + "M. E. Counts (OC)", + "S. Roberts (OC)", + "R. Cox (OC)", + "S. Rivera (OC)", + "D. Dangoor (Ryebrook)", + "A. Schwartz (NYO)", + "R. Fenner (QA)", + "J. Smith (RD&E)", + "C. Hatcher (OC)", + "A. Snyder (OC)", + "A Kottsieper (Ryebrook)", + "J. Spruill (OC)", + "S. Laffoon (OC)", + "M. Szymanczyk (NYO)", + "S. LeVan (NYO)", + "W. Webb (NYO)", + "C. Lilly (OC)", + "A. Lopez (Ryebrook)", + "M. Mahan (NYO)", + "T. McGovern (NYO)", + "2 of 7", + "PM3000469762", + "Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/ffpv0150" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004281.json b/doc_00004281.json new file mode 100644 index 0000000000000000000000000000000000000000..8fb0178fb850f588ec2cfe95aae1351fb766d579 --- /dev/null +++ b/doc_00004281.json @@ -0,0 +1,5000 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.145561, + 0.127554, + 0.082673, + 0.00823 + ], + [ + 0.759831, + 0.127999, + 0.057158, + 0.009786 + ], + [ + 0.145187, + 0.15462, + 0.019924, + 0.007981 + ], + [ + 0.14594, + 0.181618, + 0.036085, + 0.007968 + ], + [ + 0.146301, + 0.20824, + 0.018939, + 0.008097 + ], + [ + 0.183343, + 0.207892, + 0.27408, + 0.010056 + ], + [ + 0.489409, + 0.208142, + 0.250465, + 0.009896 + ], + [ + 0.784596, + 0.20844, + 0.033983, + 0.008075 + ], + [ + 0.14615, + 0.221281, + 0.159575, + 0.010076 + ], + [ + 0.14593, + 0.235055, + 0.063601, + 0.008337 + ], + [ + 0.146201, + 0.248162, + 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of state and local tax burdens, \"A Far Cry From Fair,\" at a national news conference with simultaneous press", + "events in seven targeted states on Monday, April 22, 1991. A Video News Release (VNR) was also issues and television interviews with CTJ director", + "Robert Mcintyre were conducted in ten major markets, all via satellite. The following is a summary of the sponsoring organizations and speakers for", + "each of these events, press coverage and subsequent media impact.", + "NATIONAL RELEASE", + "Speakers at the National Press Club in Washington, D.C. were Bob Mcintyre and Michael Ettlinger, CTJ director of state and local tax policy, and a", + "co-author of the study.", + "The conference was heavily attended by representatives of national media outlets and news services. Outlets represented included the", + "Cable", + "News", + "Network (CNN), ABC-TV, Associated Press (AP), United Press International (UPI), The Wall Street Journal, The Washington Post, Knight-Ridder", + "Newspapers, Gannett News Service, Newhouse News Service, States News Service and Scripps-Howard News Service. Other attendees included", + "representatives from 11 newspaper services, two periodicals and a local television station.", + "Stories concerning the national release of the CTJ study appeared on ABC-TV's \"Nightly News,\" CNN's \"NewsDay\" and \"Early Prime,\" and", + "in the Associated Press, USA Today, The Wall Street Journal and The Washington Post. The Washington Post also published an editorial citing the", + "study and urging states to pursue progressive tax alternatives. (See Appendix A for copes of national print coverage.)", + "STATE RELEASES", + "Connecticut", + "A press conference releasing the study was held in the state capitol building in Hartford. The press conference was sponsored by Taxpayers", + "Alliance to Serve Connecticut (TASC). TASC members include the League of Women Voters of Connecticut, the state AFL-CIO, the United Church", + "of Christ, the Connecticut Citizen Action Group and the Connecticut Association for Human Services.", + "Speakers at the press conference included state representative Geri Langlois (D-Thompson), Kay Maxwell (State President of the League of Women", + "Voters) and John Olsen (President of the state AFL-CIO). (See Appendix B for copies of speakers' statements.)", + "Representatives from six daily newspapers, five radio stations and the Associated Press attended the press conference. Stories have appeared in", + "the Associated Press, The Hartford Courant, The New Haven Register and on four radio stations in Hartford including WPOP-AM, the citys all news", + "station.", + "Illinois", + "Midwest Citizens for Tax Justice held a press conference in Chicago at the Bismarck Hotel to announce the release of the study. David Wilhelm,", + "director of Midwest CTJ, spoke at the conference.", + "Media attendees included representatives from four daily newspapers, (including The Chicago Tribune and The Chicago Sun-Times), three", + "television stations, five radio stations, two syndicated newspaper services and Crain's Business Journal. Stories appeared in The Chicago Tribune", + "and The Chicago Sun-Times. Coverage also appeared on WTTW-TV (PBS) and WGN-TV (Independent and nationally syndicated via cable).", + "(See Appendix B for copies of print coverage.)", + "Indiana", + "A press conference sponsored by Taxpayers for a Better Indiana was held in the state capitol in Indianapolis. Members of the Indiana coalition", + "include the state AFL-CIO and representatives from several religious, social service, community and employer organizations.", + "Charles Deppert (President, Indiana AFL-CIO) spoke at the conference and announced the formation of a new coalition, Taxpayers for Better Indiana,", + "(See Appendix B for statement) Media attendees included representatives from eight daily", + "newspapers, two local television stations, three local radio", + "stations, Network Indiana (a statewide radio network) and the indiana Labor News.", + "Stories concerning the Indiana release have appeared in The Indianapolis News, The Indianapolis Star, the Louisville Courier-Journal and on two", + "Indianapolis television stations, WISH-TV (CBS) and WTHR-TV (NBC).", + "lowaThe iowa state study was released by the kowa Citizen Action Network (ICAN) and the lowa Tax Reform Coalition (ITRAC). ICAN is a", + "TI4181-5126", + "Source: https://www.industrydocuments.ucsf.edu/docs/krlb0046" + ] + }, + { + "bbox": [ + [ + 0.144863, + 0.114731, + 0.673649, + 0.009854 + ], + [ + 0.145229, + 0.128169, + 0.177193, + 0.009739 + ], + [ + 0.144694, + 0.141255, + 0.673133, + 0.010249 + ], + [ + 0.145623, + 0.154791, + 0.256757, + 0.010196 + ], + [ + 0.14578, + 0.168118, + 0.67208, + 0.010146 + ], + [ + 0.145447, + 0.181728, + 0.505807, + 0.009769 + ], + [ + 0.145654, + 0.194979, + 0.672153, + 0.009986 + ], + [ + 0.144842, + 0.208271, + 0.673753, + 0.009902 + ], + [ + 0.145994, + 0.22179, + 0.672176, + 0.010478 + ], + [ + 0.14549, + 0.235166, + 0.467053, + 0.010203 + ], + [ + 0.146165, + 0.248889, + 0.046596, + 0.009928 + ], + [ + 0.146104, + 0.26222, + 0.672059, + 0.009797 + ], + [ + 0.145642, + 0.275671, + 0.672204, + 0.010077 + ], + [ + 0.146346, + 0.289284, + 0.207234, + 0.009826 + ], + [ + 0.146112, + 0.302743, + 0.053875, + 0.008319 + ], + [ + 0.145813, + 0.316026, + 0.672982, + 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citizens, labor and community. ITRAC is a coalition of", + "citizen, church and labor organizations.", + "A press conference was held in the state capitol in Des Moines, Speakers included Jay Larsen (executive director for ICAN) and Paui Stanfield", + "(ITRAC spokesman). (See Appendix B for statements.)", + "Reporters from The Waterloo Gazette, Associated Press, Radio towa and WHO-AM (Des Moines) attended the press conference. Radio lowa", + "feeds stories to more than 40 stations throughout the state and WHO-AM's broadcasts reach most of the state.", + "Print stories appeared in The Des Moines Register, The Cedar Rapids Gazette, The Sioux City Journal, The Ottumwa Courier, The Clinton Herald,", + "The Dubuque Telegraph Herald, The Quad City Times, The Waterloo Courier and The Mason City Globe Gazette. Television stations KCCITV", + "(CBS) and WHO-TV (NBC) ran stories on the lowa release of \"A Far Cry From Fair,\" as did radio stations KIOA-AM (Des Moines), KRNT-AM (Des", + "Moines), KUNI-AM (Cedar Falls) and WOI-AM (Ames). (See Appendix B for available print coverage.)", + "Michigan", + "Citizens for Tax Justice distributed a press release in Michigan to targeted media outlets. Stories appeared in The Detroit Free Press and The Flint", + "Journal. The Great Lakes Media Group Radio Network, which feeds stories to over 50 stations throughout the state, also ran stories on the study.", + "(See Appendix B for available print coverage.)", + "Minnesota", + "Minnesota Citizens for Tax Justice held a press conference in the state capitol in St. Paul to release the study. Wayne Cox, executive director of", + "Minnesota CTJ, spoke at the conference.", + "Approximately 17 reporters attended the press conference, including representatives from all four Minneapolis/St. Paul television", + "stations. The report made the front page of both The Minneapolis Star-Tribune and The St. Paul Pioneer-Press. Each of the television stations ran", + "stories on the evening of April 22. Cox also did a dozen taped and live radio interviews with stations throughout the state. (See Appendix B for copies", + "of print coverage.)", + "Pennsylvania", + "A press conference releasing \"A Far Cry From Fair\" was held in the state capitol in Harrisburg. The conference was sponsored by Pennsylvania", + "Citizen Action Network.", + "Speakers at the press conference included Brian Barno (Director of the Harrisburg office of Citizen Action), Dave McKann (Service", + "EmployeesInternational Union) and state representatives P. Michael Sturla (D-Lancaster) and Allen Kuckovich (D-Manor).", + "Media attendees at the conference included representatives from four daily newspapers, three local television stations, Associated Press, United", + "Press International and three radio stations.", + "Stories appeared on WHP-TV (CBS) and WHTM-TV (ABC) in Harrisburg, WGAL-TV (NBC) in Lancaster, KDKA-AM in Pittsburgh, and in The", + "Harrisburg Patriot-News and The Philadelphia Inquirer.", + "Wisconsin", + "Three separate press conferences were held in Wisconsin to release the CTJ study. In Madison, the conference was held in the state capitol and", + "was sponsored by the Wisconsin Action Coalition. Jeff Eagan, executive director of Wisconsin Action, spoke at the conference. Media attendees", + "included representatives from five daily newspapers, Associated Press, one local television affiliate (ABC), four local radio stations and Wisconsin", + "Public Radio. Stories appeared in The Madison Capital Times and the Associated Press. (See Appendix B.)", + "The Wisconsin AFL-CIO sponsored a press conference held in Milwaukee in the state AFL-CIO headquarters. David Newby of the state AFL-CIO", + "spoke at the conference. Media attendees included one daily newspaper, three local television stations (ABC, CBS and Fox affiliates) and one radio", + "station. Stories concerning the release appeared on the three television stations and in The Milwaukee Journal. (See Appendix B.)", + "Jeff Spinner of Midwest CTJ held a press conference in the EAU Claire county courthouse to announce the release of the study. Media attendees", + "included The Eau Claire Leader-Telegram, WEAU-TV (NBC), Wisconsin Public Radio and three local radio stations. Wisconsin Public Radio, The", + "Leader-Telegram and WEAU-TV ran stories", + "OTHER MEDIA COVERAGE", + "To date, we are aware that newspaper stories and an editorial also appeared in The Seattle Post-Intelligencer and The Tacoma Morning News", + "Tribune. (See Appendix B.) A clipping service we use will probably reveal other coverage.", + "OTHER NATIONAL EFFORTS", + "Video News Release (VNR)", + "A video news release (VNR) on \"A Far Cry From Fair was distributed following the national press conference. While a final report on the number of", + "stations that ran the VNR is still being prepared, listed below are stations that have requested hard copies of the news release, which is one good", + "indication of potential use.", + "WSFA-TV", + "Montgomery, AL", + "(NBC)", + "WGN-TV", + "Chicago, IL", + "(IND/National Cable)", + "TM4181-5127", + "Source: https://www.industrydocuments.ucsf.edu/docs/krlb0046" + ] + }, + { + "bbox": [ + [ + 0.144055, + 0.11586, + 0.052196, + 0.007956 + ], + [ + 0.352448, + 0.115549, + 0.058772, + 0.009629 + ], + [ + 0.145456, + 0.129474, + 0.030055, + 0.009498 + ], + [ + 0.144495, + 0.142536, + 0.049286, + 0.008118 + ], + [ + 0.351976, + 0.142288, + 0.071282, + 0.009861 + ], + [ + 0.145405, + 0.156163, + 0.029871, + 0.009274 + ], + [ + 0.145443, + 0.169293, + 0.044222, + 0.00802 + ], + [ + 0.35255, + 0.169146, + 0.071184, + 0.009118 + ], + [ + 0.145549, + 0.183062, + 0.029763, + 0.009536 + ], + [ + 0.144873, + 0.196132, + 0.050655, + 0.007843 + ], + [ + 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"WDAF-TV", + "Kansas City, MO", + "(NBC)", + "The following two stations ran the VNR as it was released:", + "WPTV-TV (NBC)", + "W. Paim Beach, FL", + "Monday, April 22", + "KTHV-TV (CBX)", + "Little Rock, AR", + "Monday, April 22", + "Satellite interviews", + "Satellite interviews with CTJ director Bob Mcintyre were arranged following the national press conference. The following stations conducted", + "interviews with Mcintyre:", + "Sacramento, CA", + "KXTV-TV (CBS)", + "Fayetteville, AR", + "KHOG-TV (ABC)", + "Portland, OR", + "KGW-TV (NBC)", + "West Palm Beach, FL", + "WPEC-TV (CBS)", + "Fort Wayne, IN", + "WPAA-TV (ABC)", + "Louisville, KY", + "WLKY-TV (ABC)", + "Detroit, MI", + "WKBD-TV (FOX)", + "Bangor,ME", + "WABI-TV (CBS)", + "Florence, SC", + "WBTW-TV (CBS)", + "Jefferson City, MO", + "KOMU-TV (NBC)", + "Appendix A", + "National Coverage", + "Appendix B", + "Connecticut", + "Illinois", + "Indiana", + "lowa", + "Michigan", + "Minnesota", + "Pennsylvania", + "Wisconsin", + "Other States", + "T14181-5128", + "Source: https://www.industrydocuments.ucsf.edu/docs/krlb0046" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004282.json b/doc_00004282.json new file mode 100644 index 0000000000000000000000000000000000000000..626c3dd59b5dc11dbcee56b8505845d93d5ad6e9 --- /dev/null +++ b/doc_00004282.json @@ -0,0 +1,950 @@ +{ + "pages": [ 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LAMBETH", + "T. HORTON KAY", + "ARTHUR KAY", + "LAMBETH & CO. (LIVERPOOL) LTD.", + "DYE AND TANNING EXTRACTS.", + "HHE/JK/VC.", + "TANNING MATERIALS CHEMICALS. &C", + "YOUR REF", + "THK/DAC.", + "OUR REF", + "The Research Department,", + "The British-American Tobacco Co. Ltd.,", + "51-71 Commercial Road,", + "LIVERPOOL 5.", + "Dear Sirs,", + "We acknowledge with thanks your letter with regard", + "to Frosted Para Tonguin Beans. At the moment, we are completely", + "out of stock of this material, but will have much pleasure in", + "sending you a sample when our next shipment is landed, which", + "should be, in about four to five weeks time.", + "Yours feithfully,", + "is CO Announ (LIVERPOOL)", + "LAMBETH . LTD.", + "Secrutary", + "TELEORAME: \"LAMCO\"", + "LIVERPOUL", + "TELEPHONS CENTRAL 5272/3", + "(a Lines)", + "CODES { A.B.C. BANTLEY'S", + "OFFICE & WAREHOUSE", + "GREENOCK STREET", + "IOFF PAISLEY STREET),", + "LIVERPOOL. 3.", + "12th. November 1949.", + "F.643" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004283.json b/doc_00004283.json new file mode 100644 index 0000000000000000000000000000000000000000..a654d748e9c23b1ebfff0c89734dfad8fcb4fd13 --- /dev/null +++ b/doc_00004283.json @@ -0,0 +1,976 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.130842, + 0.227509, + 0.22161, + 0.012251 + ], + [ + 0.129949, + 0.255316, + 0.164191, + 0.013965 + ], + [ + 0.130614, + 0.26933, + 0.108866, + 0.014036 + ], + [ + 0.130884, + 0.282074, + 0.200714, + 0.015109 + ], + [ + 0.130477, + 0.296138, + 0.246696, + 0.015656 + ], + [ + 0.130237, + 0.310861, + 0.063291, + 0.014732 + ], + [ + 0.130917, + 0.326425, + 0.018758, + 0.012722 + ], + [ + 0.131183, + 0.351256, + 0.163802, + 0.015334 + ], + [ + 0.132434, + 0.658737, + 0.029046, + 0.011122 + ], + [ + 0.179569, + 0.685286, + 0.082254, + 0.01168 + ], + [ + 0.134001, + 0.688368, + 0.024473, + 0.009126 + ], + [ + 0.180141, + 0.699176, + 0.081591, + 0.011684 + ], + [ + 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ID:HMS BCMP", + "TEL N0:617-738-0516", + "#843 P02", + "THE COUNCIL FOR TOBACCO RESEARCH - U.S.A., INC.", + "ORTING BIOMBDICAL INVESTIOATION", + "900 THIED AVENUB", + "NEW York, N.Y. 10022", + "(212)421-8885", + "GEOROS A. HASHIM, PR.D.", + "ASSOCIATE RESEARCH DIRECTOR", + "PRELIMINARY APPLICATION EVALUATION", + "Date: August 12, 1994", + "Reviewer 1:", + "Dr. Lynch", + "Reviewer 2:", + "Dr. Karnoveky", + "RE: Preliminary Application Number:", + "5228", + "Applicant's Name and Degree(s):", + "Susan E. Kane, Ph.D.", + "Institution:", + "City of Hope National Medical Center", + "Title:", + "Determinants of Protease Secretion in Normal", + "and Malignant Cells", + "1. Please review this application and indicate your scoring below.", + "A return envelope is provided for your convenience.", + "2. We expect the top 30% of Preliminary Applications will be encouraged to submit Full", + "Applications.", + "Top 10%", + "Top 40%", + "Top 20%", + "Top 50%", + "Top 30%", + "Below 50%", + "Reviewer's comments:", + "Meybe budget indicates too", + "many projects ? Otherwise", + "excellent proposal from", + "well-trained +productive P.I.", + "Date:", + "10/18/94 Signature:", + "Copies to: Drs. 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HASHIM, PH.D.", + "ASSOCIATE RESEARCH DIRECTOR", + "PRELIMINARY APPLICATION EVALUATION", + "Date: August 12, 1994", + "Reviewer 1: Dr. Lynch", + "Reviewer 2:", + "Dr. Karnovsky", + "RE: Preliminary Application Number:", + "5228", + "Applicant's Name and Degree(s):", + "Susan E. Kane, Ph.D.", + "Institution:", + "City of Hope National Medical Center", + "Title:", + "Determinants of Protease Secretion in Normal", + "and Malignant Cells", + "1. Please review this application and indicate your scoring below.", + "A return envelope is provided for your convenience.", + "2. We expect the top 30% of Preliminary Applications will be encouraged to submit Full", + "Applications.", + "Top 10%", + "Top 40%", + "Top 20%", + "Top 50%", + "Top 30%", + "Below 50%", + "Reviewer's comments:", + "Date:", + "Signature:", + "Copies to: Drs. Eisenberg, Ford, Hashim, McAllister", + "pa-rev2.doc rev07.11.94" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004286.json b/doc_00004286.json new file mode 100644 index 0000000000000000000000000000000000000000..4cb6ac0e03b3c086f5a0de6a6b330135b3033150 --- /dev/null +++ b/doc_00004286.json @@ -0,0 +1,28986 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.058467, + 0.166982, + 0.596085, + 0.091754 + ], + [ + 0.173875, + 0.223639, + 0.502727, + 0.089843 + ], + [ + 0.286716, + 0.311657, + 0.352385, + 0.060615 + ], + [ + 0.28311, + 0.52598, + 0.100539, + 0.012364 + ], + [ + 0.093842, + 0.540826, + 0.144889, + 0.012282 + ], + [ + 0.284616, + 0.541231, + 0.121662, + 0.012393 + ], + [ + 0.09348, + 0.560154, + 0.089642, + 0.007944 + ], + [ + 0.283408, + 0.560267, + 0.087213, + 0.008281 + ], + [ + 0.211938, + 0.560639, + 0.034539, + 0.00772 + ], + [ + 0.399655, + 0.561259, + 0.033771, + 0.00739 + ], + [ + 0.283794, + 0.575231, + 0.056993, + 0.010465 + ], + [ + 0.094376, + 0.575257, + 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Most", + "3 Microsoft", + "Admired Compa-", + "4 Dell Computer", + "nies. And every year", + "the companies that", + "5 Berkshire Hathaway", + "rise to the top ex-", + "6 Wal-Mart Stores", + "emplify precisely", + "the qualities that", + "7 Southwest Airlines", + "people have come to", + "8 Intel", + "admire in business:", + "9 Merck", + "Ingenuity. Prof-", + "itability. Laserlike", + "10 Walt Disney", + "focus. The will-", + "ingness to work", + "hard, work harder,", + "and then work just a little bit harder.", + "Many of the survey's perennial favorites", + "seem to dig in as they age. For the second", + "year in a row, General Electric is FOR-", + "TUNE's most admired company, winning", + "praise for its value as a long-term invest-", + "ment and, naturally, for the quality of", + "its management under CEO Jack Welch.", + "No. 2 Coca-Cola and No. 3 Microsoft con-", + "tinue to amaze competitors with their fi-", + "nancial stability, their use of corporate as-", + "sets, and their ability to attract capable", + "employees. Only two companies dropped", + "out of the top ten. Hewiett-Packard, No. 5", + "last year, feil to No. 18, and Johnson &", + "Source: https://www.industrydocuments.ucsf.edu/docs/fmpd0069", + "We tell you why the two", + "new companies in the top ten,", + "Dell and Wal-Mart, are just", + "Jack", + "alike-sort of.", + "Welch", + "the bottom ten", + "the top ten", + "460 Foundation Health", + "461 Fruit of the Loom", + "462 Viad", + "463 Olsten", + "464 U.S. Industries", + "465 Stone Container", + "466 Oxford Health Plans", + "467 MedPartners", + "468 Shoney's", + "469 Trump Hoteis & Casinos", + "Johnson went from No. 9 to No. 12. Their", + "replacements, Dell and Wal-Mart, have", + "achieved impressive growth and killer", + "shareholder returns through the expert use", + "of technology.", + "In the industry rankings, companies", + "that stand to profit from the Internet", + "scored especially well. America Online,", + "which has solidified its position as the pre-", + "eminent power on the Net, moved up four", + "places, to No. 2, in the computer and data-", + "services group. Sprint, the new No. 1", + "among telecommunications companies,", + "was the first major long-distance player to", + "announce it would combine voice and data", + "services on the same", + "network. Equipment", + "maker Lucent Tech-", + "nologies landed with", + "a splash in its indus-", + "try rankings, debut-", + "ing at No. 2.", + "In the financial", + "sector, \"merger\" is", + "still the magic word.", + "J.P. Morgan, the No.", + "1 commercial bank", + "every year since", + "FORTUNE began its", + "Most Admired sur-", + "vey in 1982, finally", + "lost its title this year", + "to Citicorp, which", + "merged with Traveiers Group. And Trav-", + "elers itself moved up three slots within", + "the securities industry. The No. 2 com-", + "mercial bank, Chase Manhattan, has", + "been advancing steadily over the past five", + "years, in part because of its successful", + "combination with Chemical Bank; it also", + "came through the Asian financial crises", + "relatively unscathed. Morgan Stanley", + "Dean Witter, another merger winner,", + "jumped four places in the securities", + "Getting to the customer on time: Dell", + "can make and deliver a computer within", + "24 hours of receiving the order." + ] + }, + { + "bbox": [ + [ + 0.071376, + 0.229768, + 0.247288, + 0.014243 + ], + [ + 0.071833, + 0.243049, + 0.246518, + 0.013483 + ], + [ + 0.071811, + 0.256016, + 0.246749, + 0.012696 + ], + [ + 0.071793, + 0.268621, + 0.246972, + 0.012774 + ], + [ + 0.072313, + 0.282558, + 0.087959, + 0.009779 + ], + [ + 0.086632, + 0.295464, + 0.232976, + 0.013004 + ], + [ + 0.071457, + 0.307943, + 0.247888, + 0.013092 + ], + [ + 0.071747, + 0.321281, + 0.247253, + 0.013644 + ], + [ + 0.071932, + 0.334441, + 0.247521, + 0.013572 + ], + [ + 0.072502, + 0.347094, + 0.247077, + 0.014042 + ], + [ + 0.072472, + 0.360032, + 0.247538, + 0.01301 + ], + [ + 0.073022, + 0.373402, + 0.247355, + 0.01428 + ], + [ + 0.0725, + 0.387029, + 0.24776, + 0.013555 + ], + [ + 0.072556, + 0.399857, 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NationsBank advanced this year,", + "aithough its new sibling, BankAmerica,", + "took a hit, the result of significant losses", + "overseas and the messy dismissal of CEO", + "David Coulter.", + "Companies that made news-good or", + "bad-made waves in the rankings. Viagra", + "propelled Pfizer to the No. 1 pharmaceuti-", + "cals spot, where it unseated Merck, the", + "longtime category leader. Apple, with Steve", + "Jobs at the helm and candy-colored iMacs", + "flying off shelves, greatly improved its", + "score, though it still lags behind IBM and", + "Dell. Northwest Airlines, hurt by a pilots'", + "strike, fell from No. 5 to No. 8. Boeing,", + "long king of its category, plunged in the", + "wake of massive layoffs.", + "Among the losers, a physicians' practice", + "management company, MedPartners, saw", + "its score fall 40.53%, more than any other.", + "Trump Hotels & Casinos, Oxford Health", + "Plans, and Shoney's joined it in the base-", + "ment, scoring poorly on financial sound-", + "ness, use of corporate assets, keeping tal-", + "ent, and community and environmental", + "responsibility.", + "redictable? Sure. But the compa-", + "P", + "nies that lead our list really do", + "have the sharpest managers, the", + "best-run operations, the coolest", + "products, the happiest shareholders. They", + "remind us that doing things well does", + "reap rewards. Who would want it any", + "other way?", + "This year's newcomers don't appear to", + "REPORTER ASSOCIATE Len A. Costa", + "Source: https://www.industrydocuments.ucsf.edu/docs/fmpd0069", + "have much in common. No. 4 Dell manu-", + "factures a limited number of customized", + "products to sell online and over the phone,", + "mostly to large companies. Dell is sleek,", + "high tech, and virtual, with no stores. You", + "can't see it when you drive down the street.", + "No. 6 Wal-Mart, on the other hand, sells", + "millions of items to millions of people:", + "everything from African violets to zippers,", + "everywhere from California to Germany.", + "With more than 3,000 stores, it's literally,", + "physically, everywhere. There's nothing", + "spare about it. Folksy to the core, Wal-", + "Mart executives are as likely to lead", + "employees in the company cheer as they", + "are to cite sales figures or operational", + "details.", + "But a closer look at the two companies", + "reveals similarities. Both have famous", + "CEO-founders. Both have killer stocks.", + "Dell, which has gained 87,000% since", + "1990, is already legendary. Wal-Mart has", + "rebounded nicely from an early '90s slow-", + "down, adding 290% to its stock price over", + "the past two years. Most of all, both com-", + "panies are operational superstars, ob-", + "sessed with quick product delivery. Keenly", + "focused on their customers, they measure", + "performance in minutes and seconds,", + "rather than days and hours. And they force", + "suppliers to keep pace. By maintaining low", + "inventories and streamlining processes,", + "they cut costs and pass the savings along to", + "customers. Both companies steep employ-", + "ees in this philosophy. Dell bases bonuses", + "largely on the company's return on in-", + "vested capital-that is, how efficiently it", + "operates. At Wal-Mart, every employee is", + "expected to read and understand endless", + "printouts of sales and inventory data.", + "Technology makes all this possible. But", + "while Dell and Wal-Mart spend scads on", + "computers and do amazing things with", + "them, their executives bristle when asked to", + "talk tech. All those fancy systems are just", + "tools, they say. The means to an end. It's", + "that attitude-unwillingness to get mired in", + "technology for technology's sake-that", + "keeps both companies ahead of the pack.", + "At Dell everyone talks about the direct", + "model, the company's practice of eliminat-", + "ing middlemen and selling PCs directly to", + "customers. \"Our only religion is the direct", + "model,\" says vice chairman Kevin Rollins.", + "CEO Michael Dell's new book is called Di-", + "rect From Dell; a company-customer pow-", + "wow scheduled for this summer will be", + "called Direct to Dell. Ask an executive", + "what it's like working with the Chinese gov-", + "ernment, one of Dell's newest customers,", + "and he says approvingly, \"They really un-", + "derstand the direct model.\" Everything is", + "direct, direct, direct. \"Analysts complain", + "that we say the same thing over and over,\"", + "says vice chairman Mort Topfer. The repe-", + "tition may grate, but being direct has made", + "Dell a powerhouse by putting it in constant", + "touch with customers, enabling it to re-", + "spond almost immediately to problems, and", + "giving it constant, actionable feedback.", + "In the 15 years since Michael Dell began", + "selling computers from his University of", + "Texas dorm room, his company has grown", + "into an $18-billion-a-year business that sells" + ] + }, + { + "bbox": [ + [ + 0.159821, + 0.177806, + 0.075608, + 0.00988 + ], + [ + 0.668736, + 0.175332, + 0.184046, + 0.013294 + ], + [ + 0.083084, + 0.214133, + 0.144232, + 0.01026 + ], + [ + 0.082792, + 0.227312, + 0.145101, + 0.012173 + ], + [ + 0.367067, + 0.214312, + 0.480737, + 0.035832 + ], + [ + 0.083269, + 0.24073, + 0.14451, + 0.012085 + ], + [ + 0.083129, + 0.253615, + 0.143879, + 0.011129 + ], + [ + 0.369362, + 0.252246, + 0.482752, + 0.01498 + ], + [ + 0.083306, + 0.266327, + 0.145132, + 0.012441 + ], + [ + 0.350764, + 0.267464, + 0.328005, 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Coca-Cola and Disney disappointed with", + "and Compaq. Dell is", + "meager returns, but still get plenty of admiration.", + "gunning for other parts", + "of its rivals' business too,", + "THE MOST ADMIRED", + "THE LEAST ADMIRED", + "such as servers and high-", + "TOTAL RETURN", + "TOTAL RETURN", + "margin storage products;", + "COMPANY", + "1998", + "1993-98*", + "COMPANY", + "1998", + "1993-98*", + "it now sells almost 20%", + "General Electric", + "41.0%", + "34.2%", + "Trump Hoteis & Casinos", + "N.A.", + "of the PC servers bought in the U.S., ac-", + "Coca-Coia", + "1.3%", + "26.1%", + "Shoney's", + "-57.7%", + "-43.1%", + "cording to Roger Kay, an analyst at Inter-", + "Microsoft", + "114.6%", + "68.9%", + "MedPartners", + "3-76.5% N.A.", + "national Data Corp. Dell is also expanding", + "Dell Computer", + "248.5%", + "152.9%", + "Oxford Health Plans", + "12-4%", + "internationally. Michael Dell says he even-", + "tually hopes to control 20% to 25% of the", + "Berkshire Hathaway", + "152.2%", + "33.8%", + "Stone Container**", + "5.8%", + "global PC market and aims to unseat leader", + "Wal-Mart Stores", + "107.6%", + "27.6%", + "U.S. Industries", + "(38.4%", + "STUNA.", + "Compaq (which has a 14.8% market share", + "Southwest Airlines", + "38.4%", + "6.6%", + "Oisten", + "$49.9%", + "-16.7%", + "worldwide) in every region it serves.", + "tatel", + "69.0%", + "50.6%", + "Viad", + "# 59.4%", + "27.0%", + "Dell executives are confident that tech-", + "Merck", + "E-41.3%", + "37.0%", + "Fruit of the Loom", + "246.1%", + "10.6%", + "nology will help them capture those new", + "Walt Disney", + "$-8.5%", + "16.9%", + "Foundation Health Systems", + "14.6%", + "Fin.A.", + "customers. \"We're always looking to see", + "what we can do to make our customers'", + "S&P 500", + "27.1%", + "23.5%", + "S&P 500", + "lives easier or save them money,\" says Mi-", + "chael Dell. \"It pervades every part of the", + "N.A. Not available. *Compound annual rate. **Company was acquired Nou 18, 1998; returns are calculated through that date.", + "company. It might be a design challenge;", + "it might be a manufacturing and distribu-", + "engineers have sped up production, bit by", + "used to move them one at a time. Near the", + "tion challenge.\" Take manufacturing.", + "tiny bit (collectively, Dell engineers have", + "end of the line, almost-finished computers", + "Dell makes its OptiPlex desktop comput-", + "more than 200 process-related patents).", + "sit on racks, ready for software installa-", + "ers at a 250,000-square-foot facility called", + "Workers used to touch a computer 130", + "tion. Employees plug the computers in to", + "Metric 12 in Austin, Texas. Bar-code", + "times in the process of assembling it; that", + "special adapters to download the software,", + "readers flicker incessantly as they follow", + "number is down to 60. At one station near", + "which takes 45 to 90 minutes. Dell engi-", + "each PC on its journey down the line. A", + "the beginning of the line, workers attach", + "neers are working on an automatic instal-", + "steady stream of trucks drops off raw ma-", + "motherboards and power-supply units to a", + "lation system that will reduce that time to", + "terials from suppliers and picks up fin-", + "computer's chassis. This effort, which once", + "20 minutes. Even now, Dell can assemble", + "ished computers.", + "required six screws, now takes one. Farther", + "OptiPlex computers in five hours or less.", + "A Dell employee walks along the pro-", + "down, a forklift-like tool called the stacker", + "Dell is equally single-minded about", + "duction line to show where the company's", + "moves piled PCs in groups of five; workers", + "electronic commerce, which causes so", + "Source: https://www.industrydocuments.ucsf.edu/docs/fmpd0069" + ] + }, + { + "bbox": [ + [ + 0.624983, + 0.150123, + 0.243741, + 0.012707 + ], + [ + 0.624513, + 0.163128, + 0.243256, + 0.011917 + ], + [ + 0.624665, + 0.176195, + 0.243571, + 0.012256 + ], + [ + 0.625112, + 0.188995, + 0.243744, + 0.012661 + ], + [ + 0.6252, + 0.202003, + 0.24235, + 0.011562 + ], + [ + 0.624561, + 0.21524, + 0.243791, + 0.010918 + ], + [ + 0.624579, + 0.22868, + 0.243144, + 0.012584 + ], + [ + 0.624857, + 0.241042, + 0.243056, + 0.013352 + ], + [ + 0.62526, + 0.254754, + 0.242515, + 0.011826 + ], + [ + 0.625014, + 0.266788, + 0.192447, + 0.01148 + ], + [ + 0.639828, + 0.279523, + 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Michael Dell isn't", + "likely to drop in on a customer who works", + "from home, but he might talk to her", + "through one of the \"Breakfast With Dell\"", + "seminars broadcast over the Net. \"We", + "stand to benefit quite a bit from [the In-", + "ternet],\" says Dell. \"A lot of our competi-", + "tors are going to be challenged, because", + "they're stuck with an old model.\"", + "Direct from Austin, Dell has loudly pro-", + "claimed itself the new model.", + "ive hundred miles north, at Wal-", + "F", + "Mart Store No. 1 in Rogers, Ark.,", + "a man leans over a freezer full of", + "boneless, skinless chicken breasts.", + "He swipes a hand-held computer over a bar", + "code near the freezer. Within seconds,", + "computers in the home office download a", + "pile of statistics: how much the Rogers store", + "makes selling chicken breasts, how many", + "packages it has on hand, how many are on", + "their way to the store, how many are sitting", + "in freezers within a 150-mile radius.", + "Wal-Mart's computers track everything", + "there is to know about everything the com-", + "pany sells. They know how much an item", + "costs; the time a checkout person needs to", + "to scan it at the register; other items cus-", + "tomers tend to buy along with it; and how", + "many more the supplier has on hand. And", + "Wal-Mart's executives know exactly how", + "to use that data to keep the company's", + "merchandisers in sync with its stores, its", + "stores in sync with its distribution centers,", + "its distribution centers in sync with its sup-", + "pliers. If Dell is all about being direct,", + "Wal-Mart is all about being exact.", + "Wal-Mart made its first top-ten appear-", + "ance on FORTUNE's Most Admired list", + "in 1987, when it had revenues of $12 bil-", + "lion. Then as now, the world's largest", + "mass-market retailer was admired for its", + "relentless customer focus, its sophisti-", + "much confusion for so many companies.", + "This kid will find more than just balloons", + "cated distribution, and its superior infor-", + "Dell does about 20% of its business online", + "inside: Wal-Mart's new Supercenters sell", + "mation systems. But Wal-Mart fell out of", + "($10 million a day) and expects that even-", + "groceries as well as discount wares.", + "the top ten in 1993, shortly after Sam Wal-", + "tually half its sales will be through the In-", + "ton's death from bone cancer. While sales", + "ternet. \"Michael says the Internet is the", + "save money. Ford Motor cut procurement", + "remained strong, executives had begun to", + "ultimate direct model,\" explains Topfer.", + "costs by $2 million when it moved its Dell", + "believe that sustaining consistent earnings", + "In 1997 the company created Premier", + "business online. Dell saved money on the", + "growth year over year depended on de-", + "Pages, Websites that enable a customer's", + "Ford deal too, because it didn't have to", + "veloping new markets. \"It had become", + "authorized employees to research, config-", + "hire as many order-entry people.", + "clear that we needed to reposition our-", + "ure, and price the PCs they plan to buy. To", + "The Net is transforming Dell's sales to", + "selves,\" says CEO David Glass. Wal-Mart", + "minimize processing errors, all informa-", + "small businesses as well. It used to be that", + "began investing what would eventually be-", + "tion specific to the customer-system", + "the small fry couldn't dream of getting", + "come nearly $20 billion to open new", + "preferences, support details, inventory", + "the sort of service Dell gave its FORTUNE", + "stores abroad and to build Supercenters,", + "management policies-is included on the", + "500 customers. Now they (almost) can.", + "combined grocery and general merchan-", + "Web page. Like the manufacturing im-", + "\"Our goal is to take all the expensive", + "dise stores. Wall Street began to wonder", + "provements in Metric 12, Premier Pages", + "things we do for large accounts and make", + "if the company had lost its focus; the stock", + "Source: https://www.industrydocuments.ucsf.edu/docs/fmpd0069" + ] + }, + { + "bbox": [ + [ + 0.152288, + 0.139417, + 0.233093, + 0.011014 + ], + [ + 0.152572, + 0.152626, + 0.232679, + 0.011411 + ], + [ + 0.152724, + 0.165698, + 0.232569, + 0.011843 + ], + [ + 0.152763, + 0.178673, + 0.231225, + 0.012102 + ], + [ + 0.152817, + 0.192213, + 0.188578, + 0.011822 + ], + [ + 0.167001, + 0.205442, + 0.218533, + 0.012249 + ], + [ + 0.153504, + 0.21847, + 0.232464, + 0.011599 + ], + [ + 0.153328, + 0.231124, + 0.232567, + 0.011032 + ], + [ + 0.153077, + 0.244831, + 0.224774, + 0.011557 + ], + [ + 0.167128, + 0.257691, + 0.21906, + 0.012121 + ], + [ + 0.153647, + 0.271095, + 0.232313, + 0.009513 + ], + [ + 0.15334, + 0.283833, + 0.232659, + 0.011769 + ], + [ + 0.153497, + 0.296893, + 0.232801, + 0.011969 + ], + [ + 0.153801, 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Wal-Mart insisted it would", + "post $100 billion in annual revenues by", + "the end of the decade. just as Mr. Sam", + "had promised. But observers-includ-", + "ing FORTUNE-were skeptical.", + "They-and we-were wrong. Wal-", + "Mart will soon report fiscal 1999 revenues", + "of $137 billion. Its stock is back too; in-", + "vestors got a return of 107.6% last year.", + "The Bentonville, Ark., headquarters", + "has a low-tech ambiance. Wal-Mart lore", + "has it that Walton used to print out com-", + "puterized reports, copy them in long-", + "hand. and tack them to a wall in his of-", + "fice. CEO Glass doesn't even have a", + "computer in his office; neither does sen-", + "ior vice chairman Don Soderquist. \"Sam", + "never liked technology,\" Glass says. \"He", + "thought 'damn computer' was one word.\"", + "Yet Walton allowed Glass to compu-", + "terize Wal-Mart. In 1976, Glass super-", + "vised construction of a satellite network", + "that enabled stores to communicate", + "with the central office (think of it as a", + "proto-intranet). He also computerized", + "the company's distribution systems,", + "which he says were shockingly anti-", + "quated in 1978: \"We were way behind.", + "But being way behind was the best thing", + "that ever happened to us.\" Because of", + "its isolation from most technology and", + "distribution centers, Glass explains,", + "Wal-Mart was able to design and build", + "its systems from the ground up.", + "Most companies these days are dis-", + "carding homegrown computer systems", + "in favor of cheaper, prewritten programs", + "they buy off the shelf. But more than", + "90% of Wal-Mart's software is still writ-", + "ten in-house by 1,000 full-time develop-", + "ers. Explains CIO Randy Mott, who as", + "a young programmer helped write the", + "1978 distribution software: \"We study", + "off-the-shelf software to make sure", + "we're not missing anything. But those", + "programs tend to be very broad. We try", + "to make our software very specific to", + "our business. With the volume we're", + "dealing with, it makes sense for us to", + "know how to do this.\"", + "In other words, aw-shucks mythology", + "notwithstanding, Wal-Mart has made", + "technology a core competency. At the", + "same time, the company spends less on", + "technology, as a percentage of sales,", + "than other retailers-0.5% last year, vs.", + "1.43% for the industry. Wal-Mart can", + "do this because of its size. \"They reap", + "economies of scale from being so large,\"", + "says Kurt Potter, a research analyst with", + "the Gartner Group. Wal-Mart's com-", + "Source: https://www.industrydocuments.ucsf.edu/docs/fmpd0069", + "puter centers in Bentonville and Tulsa", + "can store 43 terabytes of data-more", + "than any other corporation's. In an in-", + "teresting turnabout, Amazon.com has", + "hired away several Wal-Mart IT execu-", + "tives, and Wal-Mart is now suing the on-", + "line book company for stealing its intel-", + "lectual property and trade secrets.", + "\"What we've built here doesn't exist", + "anywhere else,\" says Mott. \"They've", + "replicated things that are proprietary.", + "All their ideas about retail distribution", + "come from here. It's targeted raiding.\"", + "(Wai-Mart, by the way, sells hardly any-", + "thing online. \"We'll be there to take ad-", + "vantage at the right time, and in the", + "right way,\" says Mott. \"First, we need to", + "find a profitable business model. A le-", + "gitimate retailer makes a profit,\" he", + "adds, in another dig at Amazon.com.)", + "W", + "al-Mart is nothing if not", + "legitimate and profita-", + "ble. Even its big-ticket", + "investments are begin-", + "ning to pay off. The company has more", + "than 500 Supercenters, and Glass plans", + "to open 150 new ones every year. Wal-", + "Mart is also introducing smaller grocery", + "stores it calls Neighborhood Markets,", + "aimed at shoppers who don't have the", + "time (or the inclination) to wander", + "through 200,000 square feet looking for", + "peanut butter.", + "Abroad, a Wal-Mart outpost opens", + "every week. Point-of-sale data flowing", + "back to Bentonville reveal unexpected", + "market trends. Mexicans, it turns out,", + "how the list was created", + "FORTUNE's list of Most Admired Companies is the definitive re-", + "port card on corporate reputations. To rank the top ten, we asked Clark", + "Martire & Bartolomeo (CM&B) to survey more than 10,000 executives,", + "directors, and securities analysts. They were toid to choose the com-", + "panies they admire most, regardless of industry. To create the 55", + "industry lists, FORTUNE relied solely on the insiders. CM&B asked bal-", + "lot recipients to rank companies in their own industry on eight crite-", + "ria, ranging from long-term investment value to social responsibility.", + "The result, backed by 17 years of experience, is an industry-by-industry", + "guide to corporate America's shiniest reputations.", + "flip page", + "to see more", + "MOST ADMIRED", + "love bagels. \"We can't make enough of", + "them!\" says Bobby Martin, who runs", + "Wal-Mart's international business.", + "Smoke detectors are a surprise hit in", + "Brazil. Puerto Ricans buy house paints", + "in the winter. Even the corny Wal-Mart", + "culture seems to be a successful export.", + "Police dispatched to check out a racket", + "behind a Frankfurt-area Wal-Mart", + "found 35 employees practicing the com-", + "pany cheer. \"Everyone said there was no", + "way we'd get people in Germany to do", + "the cheer,\" says Martin. \"Honest story.\"", + "CEO Glass, at age 63, says he will", + "now work to \"really develop the next", + "generation of management.\" He and the", + "board of directors recently promoted", + "Lee Scott. 49, to COO. That makes", + "Scott. a distribution and logistics expert,", + "Glass' heir apparent. \"I like things that", + "challenge conventional thinking,\" says", + "Scott. Like damncomputers? Scott, a", + "reader of Wired magazine, points to a", + "monitor in the corner. \"Well,\" he grins,", + "\"you've got to have a PC.\"", + "All ten companies at the top of our", + "list have a single-minded focus. Wal-", + "Mart is intent on quickly moving mer-", + "chandise to 3,000 stores. GE homes in", + "on shareholder value to create strategies", + "for growth. Microsoft hires brilliant", + "workers-and uses incentives to keep", + "them-to create and market its soft-", + "ware. Southwest Airlines promotes a", + "culture that impels employees to deliver", + "topnotch service on the ground and in", + "the air. In every case, it's a matter of", + "nurturing that unique, essential core.", + "2074983676" + ] + }, + { + "bbox": [ + [ + 0.391357, + 0.157096, + 0.130394, + 0.013471 + ], + [ + 0.540935, + 0.161252, + 0.027502, + 0.009511 + ], + [ + 0.657884, + 0.163783, + 0.158728, + 0.013523 + ], + [ + 0.391006, + 0.170538, + 0.173172, + 0.012341 + ], + [ + 0.65428, + 0.182219, + 0.089871, + 0.009455 + ], + [ + 0.8695, + 0.183576, + 0.025071, + 0.008223 + ], + [ + 0.39099, + 0.184217, + 0.17551, + 0.01301 + ], + [ + 0.390351, + 0.196249, + 0.122741, + 0.013941 + ], + [ + 0.689494, + 0.196885, + 0.053899, + 0.010215 + ], + [ + 0.663241, + 0.197463, + 0.005923, + 0.007533 + ], + [ + 0.86987, + 0.198177, + 0.0237, + 0.008123 + ], + [ + 0.68952, + 0.211159, + 0.111415, + 0.01152 + ], + [ + 0.662803, + 0.212694, + 0.007461, + 0.007606 + ], + [ + 0.870132, + 0.213232, + 0.024113, + 0.008467 + ], + [ + 0.69037, + 0.22655, + 0.058056, + 0.010265 + ], + [ + 0.662748, + 0.227303, + 0.00728, + 0.007414 + ], 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The key difference is that the tobacco in", + "Eclipse is primarily heated, rather than burned.", + "In fact, Eclipse burns only about 2 - 3% as much", + "tobacco as the leading \"light\" cigarette.", + "At the end of Eclipse is a high-purity carbon", + "tip. When a smoker lights the carbon and draws", + "on the cigarette, warm air passes through", + "tobacco that has a larger amount of glycerin", + "applied to it than tobacco from other cigarettes.", + "The heated air creates smoke by vaporizing", + "the glycerin and releasing the tobacco's natural", + "flavors and some added flavorants.", + "HOW ECLIPSE HEATS TOBACCO", + "Filter", + "Cigarette Paper/Foil", + "High-Purity Carbon Tip", + "Tobacco Blend", + "Heat Insulator", + "The components of an Eclipse cigarette", + "work much like a coffeemaker which passes", + "hot water through coffee grounds", + "to release the flavor.", + "A", + "NEW APPROACH", + "TO RISK REDUCTION", + "The best way for smokers to reduce the health risks of smoking is to quit", + "smoking. Yet, despite universal awareness of the risks of smoking, many", + "smokers continue to smoke.", + "A DRAMATIC DIFFERENCE FROM CONVENTIO", + "SMOKE COMPOSITION:", + "This dramatic difference can be observed", + "in the filter pads shown at the right, which", + "captured the smoke from five cigarettes", + "passed through identical pads under the same", + "smoking conditions.", + "Because the only part of Eclipse that bums", + "is the carbon heat source and some tobacco", + "paper around the lit end, Eclipse does not", + "\"bum down\" as other cigarettes do nor", + "does it produce ashes. In addition, Eclipse", + "produces 75% less secondhand smoke than", + "other cigarettes.", + "These differences, combined with the unique", + "taste of Eclipse, require an adjustment on", + "the part of smokers that usually takes one to", + "two weeks of smoking only Eclipse, before", + "many smokers come to prefer it to their", + "usual brand.", + "SMOKE CARCINOGENS", + "vs. CURRENT MAR", + "100", + "90", + "80", + "70", + "60", + "so", + "40", + "-", + "30", + "as", + "20", + "..", + "\"", + "10", + "o" + ] + }, + { + "bbox": [ + [ + 0.443237, + 0.087122, + 0.359877, + 0.012672 + ], + [ + 0.372488, + 0.132275, + 0.478088, + 0.011422 + ], + [ + 0.37239, + 0.146206, + 0.496855, + 0.011423 + ], + [ + 0.373077, + 0.159826, + 0.517697, + 0.011245 + ], + [ + 0.373821, + 0.189669, + 0.295873, + 0.010067 + ], + [ + 0.385281, + 0.206233, + 0.473626, + 0.011322 + ], + [ + 0.372593, + 0.219071, + 0.481444, + 0.011223 + ], + [ + 0.372954, + 0.2317, + 0.508334, + 0.011404 + ], + [ + 0.372934, + 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The following scientific", + "findings (which are discussed in great detail on our web site: www.newcig.com) have been observed:", + "LOWER CARCINOGEN LEVELS", + "The aerosol (smoke) from Eclipse contains dramatically lower concentrations of known,", + "probable and possible human carcinogens, as classified by the IARC (International Agency", + "for Research on Cancer) and the U.S. Surgeon General. [See the accompanying chart for how the", + "compounds on these lists compare with those from a commercial ultra-light cigarette.]", + "DECREASED TOXICITY", + "Condensates made from Eclipse smoke produce an 80%", + "reduction in tumor-bearing animals and a 90% reduction in the total", + "number of tumors produced in mouse skin-painting studies where", + "DERMAL TUMOR PROMOTION", + "NAL CIGARETTES", + "300", + "REFERENCE", + "250", + "LIGHT", + "200", + "CIGARETTE", + "DIFFERENT SMOKE CHEMISTRY", + "150", + "ECLIPSE", + "Eclipse nearly reverses the ratio of major", + "100", + "smoke components.", + "50", + "SMOKE FROM", + "COMMERCIAL ULTRA LIGHT", + "0", + "LEADING", + "LIGHT CIGARETTE", + "LOW DOSAGE MEDIUM DOSAGE HIGH DOSAGE", + "8% Nicotine", + "12 MG.TAR", + "8% Water", + "mice have been pretreated with a tumor initiator", + "(DMBA - dimethybenzanthracene).", + "7% Glycerol", + "Condensates (\"tar\") and whole smoke from Eclipse display", + "7.7% other", + "significantly decreased potential to cause cytotoxicity and", + "components in", + "genotoxicity in cell cultures, compared to typical cigarettes sold today.", + "cigarette \"tar", + "Rat inhalation assays demonstrate a decreased pulmonary", + "inflammatory potential in Eclipse, compared to cigarettes sold today.", + "SMOKE FROM ECLIPSE", + "REDUCED EFFECTS IN HUMANS", + "LEADING", + "8% Nicotine", + "Human smokers switching to Eclipse display reductions of", + "ULTRA LIGHT CIGARETTE", + "21% other", + "2 MG. \"TAR\"", + "approximately 75% in the mutagenicity of their urine, as measured", + "components in", + "by Ames Salmonella bacterial strains TA98 and YG1024.This result", + "cigarette \"tar'", + "35% Water", + "indicates dramatic reductions in the exposure to mutagens under", + "actual human smoking conditions.", + "URINE MUTAGENICITY", + "40%", + "80000", + "70000", + "SMOKERS", + "60000", + "50000", + "40000", + "MEASURED IN ECLIPSE", + "!KET ULTRA LIGHT", + "ECLIPSE", + "30000", + "4 MG. \"TAR\"", + "20000", + "10000", + "NON-", + "0", + "ECLIPSE", + "SMOKERS", + "A DIFFERENT", + "TYPE OF \"TAR\"", + "WEEK I", + "WEEK 2", + "WEEK 3", + "SMOKING", + "SWITCHING", + "SMOKING", + "Visual residue from the smoke", + "USUAL BRAND", + "TO ECLIPSE", + "USUAL BRAND", + "CURRENT", + "of five cigarettes passed through", + "**", + "ULTRA", + "identical pads under the same", + "LIGHT", + "smoking conditions demonstrates", + "A clinical research study was conducted at a leading medical", + "the dramatic difference", + "school. Overall, healthy smokers of approximately 40 cigarettes per", + "in the \"tar\" from Eclipse.", + "day showed a 48% reduction in pulmonary inflammation two", + "months after switching to an Eclipse prototype - which suggests a", + "Tobacco-specific nitrosamines", + "reduced risk of chronic bronchitis and possibly emphysema.", + "Source: https://www.industrydocuments.ucsf.edu/docs/hlkw022" + ] + }, + { + "bbox": [ + [ + 0.504346, + 0.091134, + 0.281487, + 0.012078 + ], + [ + 0.373058, + 0.24325, + 0.230823, + 0.011701 + ], + [ + 0.485999, + 0.277323, + 0.324772, + 0.013328 + ], + [ + 0.505837, + 0.73519, + 0.294746, + 0.008514 + ], + [ + 0.475052, + 0.746935, + 0.356948, + 0.008601 + ], + [ + 0.384137, + 0.771421, + 0.203717, + 0.010292 + ], + [ + 0.366015, + 0.791826, + 0.012152, + 0.007943 + ], + [ + 0.370968, + 0.810102, + 0.006824, + 0.008023 + ], + [ + 0.536089, + 0.820448, + 0.043969, + 0.007435 + ], + [ + 0.371287, + 0.828198, + 0.006532, + 0.007555 + ], + [ + 0.371026, + 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FINDINGS", + "COHB AND SERUM NICOTINE LEVELS", + "ECLIPSE vs. TEST SUBJECTS USUAL BRAND", + "% AVERAGE BLOOD COHB", + "10", + "8", + "BRAND", + "6", + "4", + "2", + "0", + "% COHb", + "When the Eclipse data set is examined as a whole, the decreases in toxic chemicals, reduced", + "genotoxicity and cytotoxicity in cultured cells, and reduced tumors in mice, indicate that Eclipse", + "may present less risk of cancer than other cigarettes.", + "Laboratory and clinical tests also show that Eclipse produces less inflammation in the respiratory", + "system than other cigarettes. These results could indicate lower risk of developing such smoking-", + "related diseases as chronic bronchitis and possibly, emphysema.", + "Of course, the best way to reduce the health risks associated with smoking is to quit.", + "Pregnant women and people who have cardiovascular disease or an elevated risk for it, should", + "CARDIOVASCULAR", + "DISEASE", + "It is not certain that Eclipse presents less risk", + "for cardiovascular disease. The information that's", + "available is inconclusive. Some test results", + "suggest that switching to Eclipse poses less risk", + "of developing the disease than other cigarettes.", + "Other test results suggest that smokers who", + "already have this disease may increase their risk.", + "In general, smokers have significantly higher", + "levels of carboxyhemoglobin (COHb) than", + "nonsmokers. The scientific literature indicates", + "that reported COHb levels in smokers typically", + "range between 3 and 10 percent (although", + "higher values have been reported).", + "Reynolds Tobacco has performed a number of", + "short-term studies on smokers switching from", + "their usual brand of cigarettes to Eclipse.", + "These studies have shown that, on average,", + "COHb levels in smokers of Eclipse are some-", + "what higher than the levels when they are", + "smoking their usual brand (8.2% COHb for", + "Eclipse, versus 7.0% COHb for their usual", + "brand). In some cases, individual smokers have", + "shown relatively large COHb increases.", + "However, the levels were within the range", + "(I-19% COHb) observed among smokers of", + "other cigarettes for more than 99% of those", + "who smoked Eclipse.", + "COHb elevations of this magnitude are unlikely", + "to increase the risk of cardiovascular diseases in", + "otherwise healthy smokers. However, individuals", + "with preexisting heart disease should not smoke", + "any cigarette, including Eclipse.", + "Because Eclipse has significant reductions in free", + "radicals (which may cause oxidation of lipids and", + "lipoproteins in the blood), as well as chemicals", + "that have the potential to damage DNA in", + "endothelial cells and circulating macrophages,", + "some scientists believe Eclipse may present less", + "risk for development of cardiovascular disease.", + "GLASS INSULATOR", + "There has been discussion in the scientific", + "community regarding the continuous-filament", + "glass-mat insulator that surrounds the Eclipse", + "heat source. Some scientists have claimed that", + "filaments from the heat source can be inhaled", + "and can harm smokers.", + "Reynolds Tobacco specifically designed the", + "filaments in the glass-mat insulator to be", + "nonrespirable and nontoxic. In addition, an", + "independent, external panel of inhalation", + "toxicologists, pathologists and pulmonologists", + "has determined that, \"under the conditions of", + "intended use, glass filaments in the Eclipse", + "cigarette pose no toxic or carcinogenic", + "potential to humans.\"", + "SERUM NICOTINE", + "30", + "LISUAL", + "28", + "BRAND", + "26", + "24", + "22", + "20", + "ng/ml" + ] + }, + { + "bbox": [ + [ + 0.393268, + 0.169904, + 0.187765, + 0.012721 + ], + [ + 0.392513, + 0.187896, + 0.291615, + 0.013483 + ], + [ + 0.392382, + 0.207216, + 0.172969, + 0.013126 + ], + [ + 0.391903, + 0.251924, + 0.289882, + 0.015884 + ], + [ + 0.392531, + 0.27423, + 0.069915, + 0.015461 + ], + [ + 0.405318, + 0.302044, + 0.269137, + 0.014922 + ], + [ + 0.404154, + 0.323964, + 0.185081, + 0.015525 + ], + [ + 0.405559, + 0.351493, + 0.230505, + 0.015947 + ], + [ + 0.405395, + 0.374282, + 0.137115, + 0.015834 + ], + [ + 0.405635, + 0.401727, + 0.256394, + 0.015743 + ], + [ + 0.405511, + 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inflammation", + "in smokers by 46%.", + "Produces an 80% reduction", + "in tumor bearing animals.", + "Emits 80% less secondhand", + "smoke.", + "Supporting facts on Eclipse", + "are enclosed for your review.", + "For more in-depth data or details", + "on how to communicate with a", + "physician familiar with Eclipse, visiti", + "our web site at www.newcig.com", + "une" + ] + }, + { + "bbox": [ + [ + 0.672684, + 0.156954, + 0.16965, + 0.035194 + ], + [ + 0.776261, + 0.183736, + 0.066391, + 0.007872 + ], + [ + 0.087528, + 0.657822, + 0.14313, + 0.013462 + ], + [ + 0.086715, + 0.676747, + 0.193519, + 0.013996 + ], + [ + 0.086184, + 0.716432, + 0.386178, + 0.01451 + ], + [ + 0.085148, + 0.736541, + 0.338873, + 0.014654 + ], + [ + 0.085202, + 0.756603, + 0.499077, + 0.014305 + ], + [ + 0.085739, + 0.776357, + 0.482629, + 0.01422 + ], + [ + 0.08582, + 0.796315, + 0.517419, + 0.014358 + ], + [ + 0.085084, + 0.816067, + 0.276209, + 0.014197 + ] + ], + "poly": [ + [ + { + "X": 0.672684, + 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visit our web site: www.newcig.com.", + "The web site contains a 37-page summary of the scientific tests", + "conducted on Eclipse, as well as dozens of scientific papers on", + "Eclipse that have appeared in peer-reviewed journals or have been", + "presented at scientific conferences." + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004288.json b/doc_00004288.json new file mode 100644 index 0000000000000000000000000000000000000000..c46cb196e56ab6a3c63422bd9dc9adc3540f098e --- /dev/null +++ b/doc_00004288.json @@ -0,0 +1,32410 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.220327, + 0.129877, + 0.685878, + 0.020244 + ], + [ + 0.20967, + 0.356969, + 0.028603, + 0.02908 + ], + [ + 0.239714, + 0.35758, + 0.308866, + 0.013413 + ], + [ + 0.238733, + 0.373613, + 0.310527, + 0.013667 + ], + [ + 0.209226, + 0.388919, + 0.340279, + 0.013451 + ], + [ + 0.208782, + 0.404958, + 0.340415, + 0.013218 + ], + [ + 0.208834, + 0.420267, + 0.3405, + 0.013654 + ], + [ + 0.209178, + 0.435652, + 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0.9942, + 0.9956, + 0.9953, + 0.9992, + 0.8462, + 0.9979, + 0.9965, + 0.9972, + 0.9995, + 0.9992, + 0.9998, + 0.9917, + 0.999, + 0.9993, + 0.9972, + 0.9984, + 0.9986, + 0.9559, + 0.984, + 0.997, + 0.9977, + 0.9873, + 0.9957, + 0.8998, + 0.9688, + 0.9972, + 0.999, + 0.984, + 0.8846 + ], + "text": [ + "Lung Cancer Among Black And White Migrants In The U.S. *i", + "S", + "tudies of disease distribution among dif-", + "ferent population groupings and aggregates", + "have often furnished important clues for", + "disease antecedents but because aggregate", + "population data can deal at best only with gross", + "characteristics, differences that occur in the", + "disease incidence among different populations", + "need to be dramatic and related to well", + "established properties before any firm conclu-", + "sions can be drawn from such data. This broad", + "approach of descriptive epidemiology has", + "focused on the major scientific unknowns: host", + "response, susceptibility, resistance and adapt-", + "ability, the influence of the environment and", + "the interrelationships of the host with the", + "environment.", + "An important observation in these studies", + "has been the marked individual variations in", + "susceptibility and resistance to carcinogenic", + "agents. Among a group of workers exposed to", + "an occupational carcinogenic agent, some", + "develop the specific cancer and others do not.", + "Host factors, inherited or acquired, exclusive", + "of exposure considerations, is an area of", + "research which has been virtually unexplored", + "in industrial studies. The present investigation", + "is concerned with the critical examination of", + "the interaction between environmental and", + "host factors.", + "Data obtained from migrant populations", + "have generally supported the hypothesis that", + "*Presented at the 1973 Meeting of the Sourh West Section of the American", + "Association fr.f Cancer Research. Houston. Texus-November 9 und 10,", + "1973", + "to Revearch Carcer Development Award K3CA 18277, National", + "Cander Institute and a Special Projedt of the Comeit for Tobacco Research.", + "USA. Inc", + "106", + "JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION", + "Etiological Considerations", + "THOMAS F. MANCUSO. M.D.,", + "Research Professor, Department of Occupational Health,", + "Gruduate School of Public Health,", + "University of Pittsburgh,", + "Pittsburgh, Pennsylvania", + "and", + "THEODOR D. STERLING, Ph.D.,", + "Professor, Division of Interdisciplinary Studies,", + "Simon Fraser University,", + "Burnaby, British Columbia,", + "Canada", + "the complex environment may contribute the", + "major carcinogenic potential in the etiology of", + "lung cancer. In general, lung cancer mortality", + "for migrant populations has been observed to", + "fall between the rates in country of origin and", + "the new host country. This observation has", + "been established predominantly for English", + "immigrants to Australia, Canada, New Zeal-", + "and, South Africa and the United States. It has", + "been observed for Jewish immigrants to Israel,", + "the United States and Canada, and for Italian", + "and Mexican immigrants to the United", + "States. I-10", + "Not only does the change in mortality", + "patterns for lung cancer point toward environ-", + "mental factors, but in some instances the", + "direction of the increase or decrease is related", + "specifically to the difference in pollution", + "between the country of birth and the country", + "of migration. English migrants, who came", + "from a highly polluted environment and", + "moved to countries with lower levels of", + "pollution, experienced a carryover but nev-", + "ertheless a decrease in lung cancer mortality as", + "did Jewish migrants from northeast Europe", + "who moved to the less polluted environment", + "of Canada or Israel.", + "However, these findings are at best sugges-", + "tive since knowledge of a migrant's original", + "environment is only approximate. Death cer-", + "tificate studies sometimes present tantalizing", + "information without satisfying the inquisitive.", + "appetite.", + "It is possible that much more precise infor-", + "mation about lung cancer may be obtained", + "01338527", + "MARCH, 1975" + ] + }, + { + "bbox": [ + [ + 0.097787, + 0.098887, + 0.341831, + 0.01323 + ], + [ + 0.097821, + 0.114401, + 0.341822, + 0.013091 + ], + [ + 0.097171, + 0.12988, + 0.342166, + 0.013431 + ], + [ + 0.097747, + 0.145289, + 0.342183, + 0.011509 + ], + [ + 0.098222, + 0.160865, + 0.341635, + 0.013663 + ], + [ + 0.098344, + 0.176269, + 0.341068, + 0.012344 + ], + [ + 0.097898, + 0.19143, + 0.342697, + 0.013335 + ], + [ + 0.097915, + 0.207088, + 0.341451, + 0.014106 + ], + [ + 0.098711, + 0.222866, + 0.341388, + 0.013863 + ], + [ + 0.098042, + 0.237875, + 0.341444, + 0.01471 + ], + [ + 0.098031, + 0.253717, + 0.341944, + 0.014115 + ], + [ + 0.097888, + 0.269904, + 0.342147, + 0.01292 + ], + [ + 0.097875, + 0.285115, + 0.342572, + 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Sauer previously reported that in", + "general for whites in the country as a whole,", + "those who had moved to another state had a", + "higher lung cancer death rate than did those", + "born in their state of residence even though", + "the all-causes death rates were quite similar for", + "the two groups. \" Haenszel found an increased", + "risk for lung cancer among white males who", + "migrated from rural to urban areas. 12 Mancuso,", + "in comparative studies by place of birth within", + "the United States and migration, demonstrated", + "a nonwhite excess over the native-born white", + "males for lung cancer and other cancer sites.°", + "A constant migration has taken place, es-", + "pecially of the black population, from the", + "American South, the American Northeast and", + "the Northwest.* A numerous population;", + "largely rural in origin, migrated from the South", + "to the industrial Northeast and North Central", + "states, and to the West Coast from 1940 to", + "1970. The pattern of black migration rapidly", + "accelerated with World War II when 1.6 million", + "blacks, nearly one sixth of the total southern", + "black population migrated north and west in", + "search of jobs and new opportunities. The exo-", + "dus from the South continued in a roughly", + "comparable pace during the decade of the", + "fifties and diminished only slightly during the", + "sixties.", + "There has been a consistent rise in lung", + "cancer mortality among blacks, in particular", + "the males, which is compatible with the", + "concept of migration for employment and the", + "subsequent latent period for environmental", + "effects. Starting with 1960 for males, the age", + "adjusted cancer death rates for blacks passed", + "that for whites and since then this disparity has", + "steadily increased.13 It must be recognized,", + "however, that the increase in total cancer in the", + "United States black population is not of racial", + "origin. While it could be possible that the", + "increase in cancer was an apparent result, due", + "in part to improved medical services for the", + "black population, the marked differences could", + "not be explained on this basis.", + "The excess of lung cancer among the", + "nonwhite males compared to white, has been", + "previously noted. The more dramatic increase", + "in lung cancer among the black males and the", + "of dissification of US Censos Population", + "Source:", + "Vol. 67. No. 2", + "Lung Cancer in ifigrants", + "107", + "females was signalled by the reports of Bur-", + "bank¹ and of Schneiderman and Levin.1+", + "It is possible that a clue for the etiology of", + "lung cancer may emerge from the comparison", + "between the age adjusted mortality of migrants", + "and of non-migrants, especially among blacks.", + "Data from the State of Ohio were used for this", + "comparison. Ohio has a large black population", + "which was rapidly and dramatically increased", + "by migration from the South. Not only did the", + "new migrants come from an impoverished", + "rural agricultural background but for a large", + "part they found work initially as industrial", + "laborers and subsequently as craftsmen and", + "operators, work which exposed them to", + "various concentrations of chemical dusts and", + "fumes.", + "METHODOLOGY", + "The population examined in detail consisted", + "of Ohio residents born in the United States or", + "in the large regions grouped by the census", + "reports as the South. All deaths of Ohio", + "residents, who died in the United States and", + "Canada, were included in the survey. Popula-", + "tion data, by specific characteristics used as a", + "basis for computing death rates, are from the", + "1960 U.S. Census. In these census reports,", + "nonwhites include Negroes, Indians, Chinese,", + "Japanese and other \"nonwhite\" individuals.", + "However, the nonwhites who were born in the", + "U.S. and migrated from the South to Ohio or", + "were born in Ohio are for the most part Ne-", + "groes so that nonwhite and black may be used", + "interchangeably for our study.4 The place of", + "birth for the deceased was taken from informa-", + "tion provided for the death certificate by", + "relatives or other persons completing the", + "certificate. The region defined as \"South\" and", + "used for classification of place of birth was", + "based on Census groupings of the States. Age", + "groupings were based on the age of the person", + "on the last birthday. Average annual age", + "specific death rates by color, sex and nativity", + "were computed on the basis of population data", + "in the 1960 U.S. Census for ages of 35 years", + "and older. The populations for the intercensus", + "years were estimated using a linear interpola-", + "tion (based on a comparison of a number of", + "different methods for estimating populations", + "\"flere bes the difference in dessfiction of betacco \"'ir", + "stodt and the 1't Burbant et . 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ASSOCIATION", + "108", + "in intercensus years that yielded largely identi-", + "ca! results) 15 Siegel's comprehensive analysis", + "of the 1960 and 1970 Census data determined", + "that the major portion of the under reporting", + "of the nonwhites in 1960 occurred under the", + "age of 35 (preferred estimates Table 5 Set D) 16", + "Death rates for the age span 35-69 years and", + "3S + were age adjusted by the direct method on", + "the basis of the age distribution of the total", + "population of continental United States in", + "1960. Data on specific dates of migration for", + "population groups were not available for con-", + "sideration.", + "FINDINGS", + "The age specific death rates and age adjusted", + "mortality rates per 100,000 for the years", + "1959-67 for Ohio residents by place of birth", + "and race for males and females, were tabul-", + "ated.*", + "There is no difference between the white", + "and the blackt males who were born in Ohio.", + "The mortality experienced for migrants.", + "however, is quite different. On the average,", + "white migrants experienced a 50% increase", + "and black migrants a 100% increase in age", + "adjusted mortality. While there are some", + "differences in the age specific rates between", + "whites and nonwhites who were born in Ohio,", + "the differences are nominal when compared to", + "the differences between native Ohioans and", + "migrants.", + "Similar differences, but less striking, occur", + "among the females. White females born in", + "Ohio have the lowest lung cancer rate followed", + "by black females born in Ohio, followed by", + "white females born in the South, followed by", + "black females born in the South.", + "The findings show that the dramatic in-", + "crease in lung cancer among black males is", + "limited to migrants. Thus, the apparent in-", + "crease in lung cancer for the total black", + "population is due principally to that part of", + "that population that migrated from a rural", + "non-industrial to an urban-industrial environ-", + "ment.", + "DISCUSSION", + "Migrant studies generally examine some", + "association of genetic, environmental and", + "be obtained from the", + "'Al teur percent of in the vensos of", + "here are other than Negro Hence. and \"Nonchite\" are used", + "by us", + "economic factors endemic in particular areas", + "and population subgroups, which in the early", + "years of life provide social and biological", + "imprints that combine with subsequent migra-", + "tion and environmental influences to bring", + "about biological imbalances which supply the", + "medium for the development of specific disea-", + "se, disability and mortality risks.9", + "A number of specific hypotheses may be", + "advanced and examined in this point.", + "Some authors in noting the increase of lung", + "cancer among nonwhites raised the possibility", + "that the increase may be related to smoking", + "habits.17 Schneiderman and Levin11 and Bur-", + "bank and Fraument13 have suggested \"that", + "nonwhites are more exposed or vulnerable", + "than whites to carcinogenic factors\" and that", + "one possible etiological factor in relation to", + "other environmental factors to be considered,", + "may be differences in smoking patterns. Exist-", + "ing evidence does not support the smoking", + "hypothesis. The frequency of smokers appears", + "to have been quite similar in 1955 for Northern", + "and Southern blacks and whites.* In fact, only", + "about half as many blacks smoked more than", + "one pack a day as did whites (both in the North", + "and South). The smaller frequency of heavy", + "smokers among blacks is due, most likely, to", + "the small income of blacks (similar findings", + "were reported by Kirchoff18 and Mills). We", + "would think it reasonable to assume that", + "smoking is completely unrelated to the dif-", + "ference in lung cancer between blacks and", + "whites and migrants and non-migrants.", + "A second hypothesis is that factors of", + "general malnutrition and related disease may", + "be involved that operate among some migrant,", + "and especially black migrant, populations.", + "Poverty for decades has been the fertile soil for", + "diseases of malnutrition, infectious diseases", + "and associated physiological impairments af-", + "fecting the susceptibility and adaptability of the", + "individual in subsequent years of life. In this", + "respect, malnutrition in combination with", + "subsequent environmental factors may have", + "some direct bearing on cancer development.", + "This is virtually an unexplored area. Saffiotti et", + "al. found that in experimental animals fed", + "large amounts of vitamin A, lung cancer was", + "inhibited.20 Conversely, the question arises,", + "would low levels of vitamin A increase the risk", + "01338529", + "MARCH, 1975" + ] + }, + { + "bbox": [ + [ + 0.097856, + 0.072342, + 0.085797, + 0.010171 + ], + [ + 0.097072, + 0.110712, + 0.114238, + 0.013358 + ], + [ + 0.11413, + 0.126494, + 0.32352, + 0.012853 + ], + [ + 0.097012, + 0.14176, + 0.341352, + 0.011623 + ], + [ + 0.095935, + 0.156992, + 0.341869, + 0.0141 + ], + [ + 0.096722, + 0.172743, + 0.340137, + 0.013937 + ], + [ + 0.096113, + 0.188163, + 0.341715, + 0.013925 + ], + [ + 0.096247, + 0.204061, + 0.341675, + 0.013031 + ], + [ + 0.095967, + 0.219915, + 0.341017, + 0.01382 + ], + [ + 0.096372, + 0.23537, + 0.340865, + 0.013709 + ], + [ + 0.096382, + 0.251172, + 0.34201, + 0.013368 + ], + [ + 0.095964, + 0.266738, + 0.34148, + 0.013461 + ], + [ + 0.094731, + 0.282498, + 0.343198, + 0.013322 + ], + [ + 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"carcinogens which prevailed in the poverty", + "areas during these decades, could be precur-", + "sors in the subsequent development of cancer", + "after migration, when these individuals are", + "exposed to urban and industrial environments.", + "Experimental as well as clinical evidence", + "exists that the host/virus relationship may be", + "disturbed by external factors. In the considera-", + "tion of migration, a major question occurs: the", + "possibility that the chemical environment may", + "activate latent tendencies (including perhaps.", + "viruses) in humans, which may produce cer-", + "tain diseases as well as cancer.21.23", + "Another hypothesis may be the exposure of", + "migrants to agricultural chemicals during", + "childhood. Southern migrants (especially", + "blacks) largely come from agricultural popula-", + "tions which tend to be heavily exposed to", + "agricultural chemicals. There has been a long", + "and woeful neglect of safety provisions for", + "agricultural laborers, especially relating to their", + "rexposure to agricultural chemicals. The rela-", + "tionships between various chemical agents and", + "cancer are too well established for us to", + "discount the possibility that migrant workers", + "may develop lung cancer and other forms of", + "cancer in later years as a response to exposures", + "to agricultural chemicals in the early formative", + "years.", + "One source of evidence that would speak", + "against this possible major role of agricultural", + "carcinogens comes from the comparison of", + "lung cancer rates in Ohio with those in", + "Southern states. Lung cancer rates for non-", + "white are consistently smaller in the South", + "than in Ohio. Similarly, the analysis of the", + "distribution of lung cancer in the U.S. clearly", + "shows that lung cancer rates are much lower in", + "the South Atlantic and Central Southern states", + "than they are in the North Central regions. It", + "is unlikely that these rates would be consis-", + "tently low if agricultural chemicals were impor-", + "tant antecedents of lung cancer, unless the", + "latent period since the introduction of these", + "chémicals has been too short to manifest the", + "carcinogenic effect directly or because of", + "competitive causes of death. Nevertheless,", + "agricultural chemicals may be considered as", + "Source:", + "Lung Canter in Migrants", + "requires further study.", + "In the consideration of the various", + "hypotheses, the industrial environment-ex-", + "posure to the carcinogenic potential of the", + "chemical environment-chemical dusts,", + "fumes, mists and gases in the work environ-", + "ment. appears as the most compelling and", + "plausible decisive factor in the development of", + "lung cancer among the migrants. Associated", + "with this are factors of urbanization and air", + "pollution.", + "capable of altering the resistance of the", + "individual to subsequent environmental car-", + "cinogenic agents following migration. and", + "The considerably higher rate for lung cancer", + "among the males versus the females for those", + "born in Ohio and those born in the South", + "provide strong support to the occupational", + "industrial factor concept. Evidence clearly", + "indicates Southern migrant populations moved", + "into the industrial North for employment. As", + "new recruits with no status, they were given", + "the assignments which invariably exposed", + "them to the adverse stresses of the work", + "environment.", + "In attempting to reconstruct the life working", + "history among the nonwhites. the term \"la-", + "borers\" as an occupation on death certificates", + "and survey forms, is frequently encountered. It", + "must be recognized that the concept and term", + "of \"laborer\" as an occupation had different", + "meanings in different industries and", + "geographical areas during three successive", + "decades as a result of the rapid industrializa-", + "tion of the United States.", + "The :erm \"laborer\" as an occupational", + "classification for the nonwhite is misleading in", + "terms of risk and frequently misinterpreted.", + "The complex nature of the working environ-", + "ment within the thousands of diverse, hazar-", + "dous redustries in the North are often not", + "appreciated. Also, not properly understood is", + "the insidious nature of the chemical environ-", + "ment and the delayed biological effects resuli-", + "ing from the dispersion and accumulation of", + "toxic dusts, fumes, mists, gases and wastes", + "throug? out various manufacturing processes", + "throughio an entire plant, to which laborers", + "as well is craftsmen and operators are exposed.", + "In this respect, it should be noted that the most", + "rapid -se for the black was the occupation", + "109" + ] + }, + { + "bbox": [ + [ + 0.208754, + 0.118667, + 0.340359, + 0.013485 + ], + [ + 0.209711, + 0.133817, + 0.338837, + 0.012862 + ], + [ + 0.20953, + 0.149531, + 0.339695, + 0.014185 + ], + [ + 0.209413, + 0.165491, + 0.339497, + 0.01344 + ], + [ + 0.20913, + 0.18122, + 0.339635, + 0.013456 + ], + [ + 0.209342, + 0.197218, + 0.339762, + 0.013114 + ], + [ + 0.209094, + 0.212856, + 0.340263, + 0.012998 + ], + [ + 0.209602, + 0.227834, + 0.339688, + 0.013387 + ], + [ + 0.209122, + 0.243469, + 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category. exposure to specific", + "harmful occupational stresses can be more", + "clearly defined. 25 The implications of these", + "aspects on epidemiological studies, warrant the", + "admonition to develop a more appropriate", + "perspective relative to occupational risks", + "among blacks.", + "We decided to test our hypothesis concern-", + "ing environmental stresses subsequent to mi-", + "gration against additional data. For this pur-", + "pose we requested a special analysis of work", + "areas and birth place from the long-term Steel", + "Workers Study (initiated by Lloyd) relative to", + "coke oven workers who had previously been", + "identified as a high risk lung cancer group. The", + "summary statement of the analysis provides", + "strong support for our hypothesis. Among", + "58,829 men employed at seven Allegheny", + "County steel plants in 1953, there were 2,543", + "men involved in coke plant operations. Their", + "mortality experience has been followed", + "through 1966. A series of papers has described", + "the methodology of this study and the finding", + "of the excess mortality from lung cancer", + "among coke oven workers.26", + "A strong association exists in this population", + "between birth place and death from lung cancer", + "in the nonwhite coke plant workers. Exam-", + "ination of these death certificates revealed that 33", + "of 35 deaths occurred among men born in the", + "South.", + "Further support for this hypothesis came", + "from an analysis of the published data of the", + "National Study of Chromate Industry con-", + "ducted by the Public Health Service.28", + "The number of person years and the number", + "of deaths compared to the expected number", + "for the United States due to respiratory cancer", + "is tabulated.4 The ratio of actual to expected", + "number of deaths due to respiratory cancer was", + "fourteen for whites, eighty for nonwhites. The", + "study included data on place of birth which", + "supported the concept of migration for em-", + "ployment for risk occupations particularly for", + "the nonwhite and also for the white. Only five", + "out of 104 black workers in four New Jersey", + "chromate plants were born within that state.", + "One-half of the black employees came from", + "These data m. be obtuned frain the Juthos", + "110", + "JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION", + "Georgia or South Carolina. Seventeen percent", + "of the Maryland black workers were born in the", + "state and 88% were from North and South", + "Carolina and Virginia.28", + "In our review of lung cancer studies we find", + "that surprisingly little work has been done on", + "the relationship of occupational exposure (and", + "exposure to pollutants) of the thousands of", + "chemicals, individually or in combination, in", + "the chemical environment and subsequent", + "lung cancers during the past three decades.", + "Epidemiologically, there are no studies which", + "encompass the analysis of the total life employ.", + "ment, of the identification and interplay of all", + "the chemicals, dusts and so forth, to which the", + "worker is subjected, in sequential multiple", + "employments in different occupations and", + "manufacturing processes during the life span", + "of an individual.", + "A recent report states \"the number of", + "varieties of worker groups having occupational", + "contact with these carcinogens is considerably", + "larger than indicated by published reports", + "because of the neglect and reluctance of", + "industrial management and most public health", + "agencies to undertake such tasks in the", + "interest of the public good.\"", + "Further, the concept has been previously", + "postulated of a combination of two environ-", + "mental complexes; air pollution and the oc-", + "cupational environment \"that air pollution", + "represents a highly probable factor in the", + "excess of lung cancer in urban areas, acting", + "directly and augmenting the occupational ex-", + "posures of men so that carcinogenic and co-", + "carcinogenic or potentiating agents of both", + "environments may be involved.\"X Compell-", + "ing evidence along these lines was also pre-", + "sented by Hettche 31.32 and by Sterling.", + "It is hoped that the findings from this study", + "will provide the impetus to broaden the", + "concepts and approaches in the consideration", + "of etiological factors associated with lung", + "cancer.", + "01338531", + "SUMMARY", + "Migrants, in particular black migrants. have", + "an increased risk for lung cancer. In a study of", + "Ohio residents, white males born in the South", + "had a 50% excess and nonwhite males 100%", + "excess, compared to those born in Ohio. Yet", + "MARCH. 1975" + ] + }, + { + "bbox": [ + [ + 0.097538, + 0.09865, + 0.337513, + 0.013848 + ], + [ + 0.098026, + 0.114401, + 0.311864, + 0.011672 + ], + [ + 0.111911, + 0.130034, + 0.32461, + 0.013224 + ], + [ + 0.095245, + 0.145324, + 0.341343, + 0.013719 + ], + [ + 0.094336, + 0.16098, + 0.343396, + 0.013606 + ], + [ + 0.09488, + 0.17652, + 0.342565, + 0.013547 + ], + [ + 0.094894, + 0.192738, + 0.237502, + 0.01294 + ], + [ + 0.11091, + 0.208138, + 0.325866, + 0.01129 + ], + [ + 0.094709, + 0.223597, + 0.343212, + 0.01259 + ], + [ + 0.095003, + 0.238959, + 0.342482, + 0.013172 + ], + [ + 0.094109, + 0.254468, + 0.343058, + 0.013406 + ], + [ + 0.094786, + 0.269938, + 0.342596, + 0.012765 + ], + [ + 0.095103, + 0.285003, + 0.341879, + 0.013621 + ], + [ + 0.09532, + 0.300599, + 0.341476, + 0.013384 + ], + [ + 0.096132, + 0.316176, + 0.341235, + 0.013928 + ], + [ + 0.095356, + 0.331541, + 0.34256, + 0.014111 + ], + [ + 0.095422, + 0.347816, + 0.245239, + 0.013313 + ], + [ + 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birth and high lung", + "cancer among the nonwhite males, 33 of 35", + "deaths occurred among men born in the South.", + "Further support of migration and risk employ-", + "ment was provided in the analysis of lung", + "cancer among chromate workers.", + "Our findings support the hypothesis that", + "lung cancer, at least among the blacks, may be", + "largely a result of migration and occupational", + "exposure to chemical dusts and fumes in the", + "industrial employment.", + "The important evidence to which we now", + "point would indicate that occupational car-", + "cinogens may be the immediate antecedents of", + "lung cancer and that region of birth in the U.S.,", + "migration and subsequent industrial employ-", + "ment are important variables in the etiology of", + "cancer of the lung.", + "ACKNOWLEDGEMENTS", + "We wish to express our appreciation for the excellent", + "assistance provided by the Ohio Department of Health, in", + "particular; Mr. William H. Veigel, Chief of Division of", + "Vital Statistics and Mrs. Betty Everett, Statistician.", + "We are also deeply grateful to Dr. Carol Redmond,", + "Graduate School of Public Health, University of Pitts-", + "burgh, for making available the crucial data on deaths", + "among nonwhite steel workers; to Mr. Arthur LeGasse,", + "University of Pittsburgh. for the computer programming", + "and production and to Dr. Emanuel Landaw, Bureau of", + "Radiological Health, Food and Drug Administration, for", + "review of the manuscript.", + "LITERATURE CITED", + "1. BEUCHLEY. R. and J.E. DUNN, G. LINDEN, and", + "L. BRESLOW Excess Lung Cancer Mortality", + "Among Mexican Women in California. Cancer. 10:", + "63-66. 1957", + "2 COY. P. and S. GRZYBOWSKI, and B.A. ROWE.", + "Lung Cancer Mortality According to Birthplace.", + "Canad. Assoc. Jour.. 99: 476-482. 1968.", + "3. DEAN. G. Lung Cancer Among White South", + "Africans. Brit. Med. Jour., 2: 852-851. 1959.", + "4. DEAN. G. 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The problems faced by the", + "Nigerian patient with untreatable primary", + "amenorrhoea are briefly mentioned.", + "ACKNOWLEDGEMENT", + "We are grateful to Professor A.O. Williams and his staff", + "for the histology reports, S.O. Akinkumi of our Paediatric", + "Department for the cytogenetic studies. our medical", + "illustration unit for the photographs, and Miss Cindy", + "Miller of the Johns Hopkins Hospital, Baltimore for the", + "secretarial assistance.", + "LITERATURE CITED", + "1. JEFFCOATE, T.N.A. Principles of Gynaecology.", + "Third Ed. Butterworths, London, 1967 pp. 186. 171.", + "McCALL. C.H. and J.M. WAUGH. Absence of the", + "2.", + "Uterus and Vagina in Association with Left Renal", + "Agenesis. Case Proc. Staff Meeting. Mayo Clinic, 19:", + "244. 1944.", + "3. WEI, E.D. Quoted by Coker. O.O. 1966.", + "4. COKER. O.O. A Case of Congenital Absence of the", + "Uterus. Nigerian Med. Jour., 2: 214-216, 1972", + "5 AIMAKHY, V.E. 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chromate-producing", + "plants compared with the expected number based on the average death rate", + "for the United States, 1940-1948, inclusive for ages 15-74 years.", + "[The chromate data include experiences of two plants during 1940-1948, one", + "plant during 1943-1948, three plants during 1946-1948].", + "Number of Deaths", + "Ratio of", + "actual to ex-", + "Annual Number of Deaths", + "Actual", + "Expected²", + "pected number", + "per 100,000 males", + "Chromate", + "Chromate", + "U.S.", + "All Males", + "26", + ".9", + "28.89", + "470.8", + "16.7", + "White Males", + "10", + ".7", + "14.29", + "261.6", + "17.4", + "Black Males", + "16", + ".2", + "80.00", + "941.7", + "10.0", + "1", + "Violent and accidental deaths not included.", + "2", + "The average death rate for the United States for the 9 years, 1940-1948,", + "multiplied by the appropriate person-years of membership in the chromate", + "plants.", + "Person-Years of Membership in Sick Benefit Association", + "of Chromate Workers by Color and Age", + "Age Group (years)", + "Total", + "Color", + "15-74", + "15-34", + "35-44", + "45-54", + "55-64", + "65-74", + "Average number of person-years of membership", + "All Males", + "5,522", + "1,574", + "1,616", + "1,411", + "796", + "125", + "White Males", + "3,823", + "1,041", + "1,091", + "919", + "659", + "113", + "Black Males", + "1,699", + "533", + "525", + "492", + "137", + "12", + "Abstracted from U.S. Public Health Service, Division of Occupational", + "Health: A Study of Health of Workers in Chromate Producing Industry.", + "30", + "the" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004289.json b/doc_00004289.json new file mode 100644 index 0000000000000000000000000000000000000000..afabf6fef23879a2aa1128e92fb67b9deb08c585 --- /dev/null +++ b/doc_00004289.json @@ -0,0 +1,2524 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.336093, + 0.125016, + 0.331249, + 0.019959 + ], + [ + 0.113709, + 0.250254, + 0.280073, + 0.019818 + ], + [ + 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Report", + "FW: Study Results", + "Dick-Come by some time and l'll tell you about these messages. --Robin", + "3042585778", + "Source: https://www.industrydocuments.ucsf.edu/docs/glwc0151" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004291.json b/doc_00004291.json new file mode 100644 index 0000000000000000000000000000000000000000..3bd5a66f72cc9f202c5e2d15d06b8f92807a5ec2 --- /dev/null +++ b/doc_00004291.json @@ -0,0 +1,2406 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.169721, + 0.114268, + 0.114308, + 0.008057 + ], + [ + 0.326669, + 0.113494, + 0.107086, + 0.008031 + ], + [ + 0.490612, + 0.112988, + 0.083961, + 0.008332 + ], + [ + 0.609051, + 0.112101, + 0.049968, + 0.008141 + ], + [ + 0.778295, + 0.112034, + 0.049415, + 0.008012 + ], + [ + 0.163989, + 0.159727, + 0.063171, + 0.009251 + ], + [ + 0.453338, + 0.158865, + 0.070932, + 0.008241 + ], + [ + 0.647863, + 0.157887, + 0.161967, + 0.008865 + ], + [ + 0.164558, + 0.217426, + 0.08546, + 0.007726 + ], + [ + 0.409235, 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Abou now mony pocis or corfom of cigarettes do you moke in c wee ?", + "packs OR", + "cortors", + "40. What is your regulor brond of cigorettes, the brond you smoke most often?", + "FULL BRAND NAME:", + "b. Does it hove \"Lights\" or \"Milds\" in in nome?", + "Lights =:", + "Milds", + "Neither", + "c. hito. Ploin filter", + "Mentho! Fiter", + "Non filter", + "d. ls it:", + "Shorter than king size", + "King size -", + "100 millimeter -", + "120 millimeter -", + "-", + "-", + "5. Compored with other cigarentes, woule you", + "A very strong teste", + "is:", + "soy that your regulor brond", + "A sirong roste", + "=", + "-2", + "=", + "An average *cue.", + "-;", + "A mild", + "A very mito toste.", + ":", + "6. How long hava you been moking your regular brand ?", + "3 months or less", + "One year", + "40 months", + "Ovar 1 year 'o 2 yem", + "7-11 montés", + "Over 2 yeon", + "7a. What one brand of cigaretres did you smoke most often before you warted smoking your regular brand (the one in", + "Ovestion 4a)?", + "NOTE: Your previous cigorerre moy have hod . complotely different brond name from the one you ore", + "smoking now, or is may hove the some brond name but was o different size or type from the", + "one you are currently woking. In either cose, pleose onawer ull parts of Ovestion 7.", + "FULL SRAND NAME:", + "b. Did it hove \"Light\" or *Milds\" in its nome", + "Lights", + "Milds", + "Neith", + "c. Was it o: Ploin filter", + "Menthol filter", + "Non i", + "d. Wos it: Sharrer thon king size", + "King size", + "100 millimeter", + "120 millimater", + "8. How long did you smoke thet brond?", + "3 or less", + "---", + "One year", + "4-6 months", + "Over 1 year to 2 years", + "7-11 mants", + "Over 2 years", + "C", + "9. Please ind'cote your age, sex and roce:", + "DATE OF BRTH:", + "Goor)", + "SEX: Mole (--7-1 Femole", + "-2", + "RACE: Whire Slock -2 Orientel 3 Other", + "PLEASE PRINT FULL NAME", + "M. Mrs. Miss Ma. (cirdle onn)", + "4a", + "(fine nome)", + "(I- ~", + "%", + "if YOUR ADDRESS IS NOT the seme - on the labul,", + "611 in correct information", + "Addross", + "City", + "State", + "Zie Code", + "Telephone", + "(aree code)", + "(", + "-4-", + "I" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004293.json b/doc_00004293.json new file mode 100644 index 0000000000000000000000000000000000000000..afa8e6a04acbf366e5e7176e7fa9cbab23aec02f --- /dev/null +++ b/doc_00004293.json @@ -0,0 +1,872 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.812557, + 0.057748, + 0.121921, + 0.027404 + ], + [ + 0.460079, + 0.088178, + 0.032807, + 0.013609 + ], + [ + 0.506696, + 0.102863, + 0.023432, + 0.016217 + ], + [ + 0.842781, + 0.104061, + 0.079906, + 0.024094 + ], + [ + 0.193806, + 0.143864, + 0.126792, + 0.010302 + ], + [ + 0.853943, + 0.147889, + 0.078811, + 0.019923 + ], + [ + 0.584028, + 0.164828, + 0.037998, + 0.008951 + ], + [ + 0.434539, + 0.178244, + 0.290309, + 0.010233 + ], + [ + 0.13483, 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FREEDMAN", + "MARKETING COUNSEL", + "February 22, 1984", + "J. Bradbury Reed, Esq.", + "Bass, Berry & Sims", + "2700 First American Center", + "Nashville, Tennessee 37238", + "Dear Brad:", + "Attached is the original of B&W's February 21, 1984 letter to", + "Cinema Concepts, a copy of which was telecopied to your office", + "this morning.", + "Very truly yours,", + "Barton H Freedman", + "Barton H. Freedman", + "ke", + "Marketing Counsel", + "/dy668li", + "Attachment", + "FILE COPY", + "Source: https://www.industrydocuments.ucsf.edu/docs/gzkg0045", + "Tan", + "TELEPHONES", + "(502) 568 - 7760", + "(502)568-7011", + "IN" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004294.json b/doc_00004294.json new file mode 100644 index 0000000000000000000000000000000000000000..b79413ca51a2f0030bea3ed07d9dee62b109e654 --- /dev/null +++ b/doc_00004294.json @@ -0,0 +1,804 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.200085, + 0.145873, + 0.011866, + 0.011838 + ], + [ + 0.274907, + 0.142561, + 0.049282, + 0.012674 + ], + [ + 0.284038, + 0.15988, + 0.031202, + 0.015135 + ], + [ + 0.206038, + 0.225577, + 0.005814, + 0.01166 + ], + [ + 0.196087, + 0.305793, + 0.01607, + 0.011633 + ], + [ + 0.196266, + 0.3854, + 0.015934, + 0.011759 + ], + [ + 0.196159, + 0.465409, + 0.015982, + 0.011614 + ], + [ + 0.19624, + 0.545046, + 0.01569, + 0.011733 + ], + [ + 0.189793, + 0.624914, + 0.022229, + 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I do so voluntarily and without any promise (other", + "than set forth herein), threat, duress, or undue influence from any party. I certify that I smoke at least", + "15", + "cigarettes per day, inhaling the smoke. I acknowledge and understand that this study will last 14 days", + "and that I will be required to report to the research testing facility for two 45-minute test sessions. I will", + "be paid $50 for the first test session and $50 for the second session, with a $50 bonus for successful", + "completion of both sessions (total possible compensation = $150).", + "I will receive a 14-day supply of experimental research cigarettes from the study administrator at the", + "conclusion of session one. I understand that I will be required to smoke these cigarettes exclusively", + "(only this cigarette) beginning the day after the first session until I return for the second test session.", + "I", + "will also be required to return any unsmoked cigarettes and a cigarette log to the study administrator.", + "I understand that if I do not fulfill all study requirements - such as smoking the research cigarettes", + "exclusively for the entire test period described above, and returning unsmoked cigarettes and the", + "cigarette log - I will not receive full compensation and may only be paid for successful completion of", + "the first test session.", + "I have been advised and understand that my involvement in the study sessions will be as follows:", + "1. I will be asked to sit in a reclining chair and have one blood sample taken in each test", + "session.", + "Some people may experience a slight discomfort when the needle is inserted or", + "withdrawn. This should not be any more uncomfortable than having any other", + "blood sample taken.", + "As is the case with any blood sample, there is a chance for the development of a", + "small hematoma (i.e. a bruise or discoloration) around the area where the needle", + "is inserted.", + "2. During each test session I will smoke one cigarette. I am aware of the Surgeon General's", + "warnings:", + "Smoking Causes Lung Cancer, Heart Disease, Emphysema, And May", + "Complicate Pregnancy.", + "Quitting Smoking Now Greatly Reduces Serious Risks to Your Health.", + "Smoking By Pregnant Women May Result in Fetal Injury, Premature Birth, And", + "Low Birth Weight.", + "Source: :ttps://www.industrydocuments.ucsf.edu/docs/gllf0188" + ] + }, + { + "bbox": [ + [ + 0.302505, + 0.078628, + 0.331776, + 0.013184 + ], + [ + 0.228604, + 0.111783, + 0.653504, + 0.013909 + ], + [ + 0.228717, + 0.128029, + 0.437799, + 0.014115 + ], + [ + 0.206266, + 0.160611, + 0.647723, + 0.014707 + ], + [ + 0.228763, + 0.177388, + 0.386281, + 0.01369 + ], + [ + 0.206333, + 0.21008, + 0.661815, + 0.014024 + ], + [ + 0.22843, + 0.226605, + 0.647064, + 0.014655 + ], + [ + 0.229257, + 0.242999, + 0.591362, + 0.014715 + ], + [ + 0.228738, + 0.259958, + 0.6262, + 0.0138 + ], + [ + 0.229016, + 0.276137, + 0.581562, + 0.014642 + ], + [ + 0.228605, + 0.292955, + 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One blood sample will be collected. The total volume of blood drawn during each test", + "session will be around 5 ml (less than half an ounce).", + "4. A blood sample will be used to determine the level of carbon monoxide in my blood. At", + "high levels of carbon monoxide in the blood, some persons may experience symptoms of", + "over-smoking. This study is not expected to result in symptoms of over-smoking.", + "However, in the unlikely event that I am advised by the test administrator that I have a", + "carbon monoxide level indicating I may have over-smoked, I agree to follow the", + "precautions requested by the administrator which may include:", + "remaining in the test center for one hour without smoking;", + "providing one or two additional blood samples;", + "remaining in the test center for a second hour without smoking;", + "being checked by medical personnel.", + "I have been advised and understand that I should not participate in the study if I have any of the", + "following conditions or symptoms of the following conditions: high blood pressure, heart disease,", + "angina (chest pain), hemophilia (i.e. tendency for excessive bleeding), anemia, diabetes (blood", + "sugar disease), kidney disease, lung disease, or any other medical condition, or skin sensitivity to", + "adhesive bandages, rubbing alcohol or iodine. I have also been advised that I should not participate", + "in the study if I am pregnant or plan to get pregnant during the period of this study. I am not", + "currently taking any prescription medications.", + "In signing this consent form and participating in this study, I affirm that I do not knowingly have any of", + "these conditions.", + "I further affirm that:", + "1. I have not visited Haiti or sub-Saharan Africa or the islands near Africa in the last 12 months.", + "I have not had sex with anyone who has been to these areas in the last 12 months.", + "2. To my knowledge I do not have AIDS or the AIDS virus nor have I had sex with anyone who", + "has AIDS.", + "3. To my knowledge I do not have a venereal disease nor have I been treated for these diseases", + "(gonorrhea or syphilis) in the last 12 months, nor have I had sex with anyone whom has.", + "4. I have never taken illicit drugs intravenously nor have I knowingly had sex with anyone who", + "uses illicit drugs intravenously.", + "5. I do not engage in homosexual activity.", + "Men: I have not had sex with another man since 1977.", + "2", + "Source: https://www.industrydocuments.ucsf.edu/docs/gllf0188" + ] + }, + { + "bbox": [ + [ + 0.265606, + 0.079888, + 0.601759, + 0.011818 + ], + [ + 0.267406, + 0.096266, + 0.039456, + 0.011228 + ], + [ + 0.177708, + 0.129207, + 0.700139, + 0.014869 + ], + [ + 0.199238, + 0.146258, + 0.506776, + 0.014415 + ], + [ + 0.177967, + 0.179169, + 0.697852, + 0.014965 + ], + [ + 0.199238, + 0.196415, + 0.552207, + 0.014169 + ], + [ + 0.118351, + 0.229093, + 0.758094, + 0.013751 + ], + [ + 0.118278, + 0.244779, + 0.70587, + 0.014244 + ], + [ + 0.118102, + 0.277407, + 0.704896, + 0.014561 + ], + [ + 0.118937, + 0.293969, + 0.698356, + 0.014355 + ], + [ + 0.118635, + 0.310284, + 0.730076, + 0.014141 + ], + [ + 0.118462, + 0.326466, + 0.745685, + 0.014316 + ], + [ + 0.118835, + 0.34326, + 0.738101, + 0.013926 + ], + [ + 0.118637, + 0.359512, + 0.764501, + 0.01437 + ], + [ + 0.118269, + 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I have never been diagnosed as having hepatitis or had a positive test for hepatitis. I have not", + "had close contact with anyone who has been diagnosed with hepatitis.", + "7. I have not had any of the following procedures in the last 12 months: tattoos, body piercing,", + "acupuncture, electrolysis or any other kind of skin piercing procedures.", + "In signing this consent form, I hereby affirm that I have answered all the questions concerning my health", + "and medical history accurately and I know of no reason why I should not participate in this study.", + "I further agree that in the unlikely event of a laboratory accident (e.g. spilled blood, broken blood", + "containers, inadvertent needle puncture of laboratory personnel) involving potential exposure of", + "laboratory workers to samples of my blood or blood serum, I hereby consent to having another blood", + "sample drawn in order to test my blood for antibodies to the HIV virus (the AIDS virus). This test will", + "be done to ensure that such laboratory personnel have not been exposed to potential blood transmitted", + "diseases. I understand that I will be notified of any such requirement and agree to return upon reasonable", + "notice and at a convenient time/place to have further blood testing performed.", + "My consent to participate in this study is subject to the foregoing terms. I understand however, that I", + "may address any questions that I have to the personnel performing the study prior to signing this form.", + "After signing this form, I understand that I can withdraw from the study at any time or have additional", + "questions answered by calling Julie Hauser or Pat Rierson at Bellomy Research (721-1140).", + "This the", + "day of", + ", 2000.", + "Participant (PRINT NAME)", + "Signature", + "Witness", + "3", + "Source: https://www.industrydocuments.ucsf.edu/docs/gllf0188" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004296.json b/doc_00004296.json new file mode 100644 index 0000000000000000000000000000000000000000..b83ffe0d763fa7baffa8d8240e44af0671e5dbe5 --- /dev/null +++ b/doc_00004296.json @@ -0,0 +1,3430 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.241811, + 0.057516, + 0.542694, + 0.013004 + ], + [ + 0.341799, + 0.088505, + 0.316586, + 0.01198 + ], + [ + 0.301227, + 0.118169, + 0.395691, + 0.011631 + ], + [ + 0.527092, + 0.180469, 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COREN", + "11", + "ALL FUNDING LETTERS FOR THE ABOVE LIST ARE ATTACHED FOR EASY REFERENCE", + "SAMPLE: REMINDER LETTER", + "DEAR DR.", + ":", + "In respect to your Grant (No.", + "which is due to terminate", + ",", + "you appear to have either overlooked the instructions in our funding letter of", + "or have decided not to reapply for a New Gmat, in campetition with others.", + "If you choose to apply, please advise us immediately.", + "Sincerely yours,", + "Source: https://www.industrydocuments.ucsf.edu/docs/ghcc0005" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004297.json b/doc_00004297.json new file mode 100644 index 0000000000000000000000000000000000000000..e0bf60f342f0b0a9b8af548e9dd4dfea31394a4e --- /dev/null +++ b/doc_00004297.json @@ -0,0 +1,820 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.205896, + 0.179049, + 0.52945, + 0.012586 + ], + [ + 0.404393, + 0.208217, + 0.13332, + 0.011476 + ], + [ + 0.348417, + 0.25195, + 0.238875, + 0.010475 + ], + [ + 0.122157, + 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LeMaistre, M.D., is president of the University, of Texas System", + "Cancer Center, I.D. Anderson Hospital and Tumor Institute in Houston. Dr.", + "LeMaistre is a member of the Board of Directors of the American Cancer Society", + "and a member of the ACS Texas Division Board and Executive Committee. He is", + "a former member of the Surgeon General's Advisory Committee on Smoking and", + "Health and past chairman of the National Conference on Smoking and Health (1981)", + "AMERICAN CANCER SOCIETY", + "Robert V.P. Hutter, M.D., is chairman of the Department of Pathology at Saint", + "Barnabas Medical Center in Livingston, N.J. Dr. Hutter is a past president of", + "the American Cancer Society (1981-82), and member of its Board of Directors.", + "He is an adjunct professor of pathology at the College of Physicians and", + "Surgeons, Columbia University and chairman of the Cancer Committee of the College", + "of American Pathologists.", + "AMERICAN LUNG ASSOCIATION", + "Walter J. Hatcher recently retired as Director of Industrial Relations for Pitney", + "Bowes, Inc., Stamford, Conn. Mr. Hatcher is President-elect of the American", + "Lung Association and past president of the Connecticut Lung Association. He", + "also serves as president of the Industrial Relations Research Association and past", + "president of the Connecticut Personnel Association.", + "AMERICAN HEART ASSOCIATION", + "Thomas J. Ryan, M.D., President-elect of the American Heart Association, is head", + "of the Section of Cardiology at the University Hospital of Boston University", + "Medical Center, and professor of medicine at the Boston University School of", + "Medicine. Dr. Ryan has been actively engaged in clinical research for the last", + "two decades. He is a member of the editorial board of the New England Journal", + "of Medicine.", + "TI04821627", + "Source: https://www.industrydocuments.ucsf.edu/docs/jljk0004" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004298.json b/doc_00004298.json new file mode 100644 index 0000000000000000000000000000000000000000..8aaf1147226b0b9cc34ddfa867117c205e34d480 --- /dev/null +++ b/doc_00004298.json @@ -0,0 +1,638 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.142096, + 0.169309, + 0.477621, + 0.029006 + ], + [ + 0.753193, + 0.166323, + 0.135547, + 0.035449 + ], + [ + 0.196313, + 0.221007, + 0.039726, + 0.01493 + ], + [ + 0.324683, + 0.224999, + 0.034716, + 0.03129 + ], + [ + 0.343984, + 0.236288, + 0.014296, + 0.00939 + ], + [ + 0.456072, + 0.246492, + 0.170794, + 0.020611 + ], + [ + 0.217619, + 0.269653, + 0.217169, + 0.018021 + ], + [ + 0.165686, + 0.289481, + 0.049455, + 0.015446 + ], + [ + 0.246857, + 0.30955, + 0.028322, + 0.011121 + ], + [ + 0.164724, + 0.346553, + 0.297108, + 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Sulend t O. Gared : highest temp.", + "ink will include is Not > 100°C", + "4/23/97", + "Per W. HUUCH 100°C is a suitable Selection of", + "thoup. For testing.", + "O. Game requested samplEs , The samples intially", + "rec'a 3/27/97 were NOY tipping pages of its.", + "No Sample was a plice of cooked", + "blank, W. Confirmed No samples of", + "traning Poser sent t will Serve samplEs.", + "4/24", + "Samples ruc'd No Sample rec'a For RSX 11140 althought", + "requestion 4/23." + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004299.json b/doc_00004299.json new file mode 100644 index 0000000000000000000000000000000000000000..15b30460ae126e711321cf8d1707765913f851b6 --- /dev/null +++ b/doc_00004299.json @@ -0,0 +1,2956 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.740268, + 0.041877, + 0.213511, + 0.031637 + ], + [ + 0.378709, + 0.112127, + 0.462548, + 0.013073 + ], + [ + 0.279663, + 0.13577, + 0.581354, + 0.013973 + ], + [ + 0.278005, + 0.161265, + 0.591801, + 0.014325 + ], + [ + 0.377856, + 0.199586, + 0.503704, + 0.013021 + ], + [ + 0.277501, + 0.224897, + 0.61297, + 0.013616 + ], + [ + 0.276612, + 0.249325, + 0.603969, + 0.01456 + ], + [ + 0.277584, + 0.275587, + 0.572519, + 0.012982 + ], + [ + 0.275175, + 0.301236, + 0.605196, + 0.013099 + ], + [ + 0.27631, + 0.325711, + 0.613505, + 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The object of the Commission's cigarette testing and", + "reporting program has always been to provide an accurate rela-", + "tive ranking of the smoke yield of cigarette varieties in ac-", + "cordance with a standardized testing procedure and to report", + "the results of such testing on a regular basis to the public.", + "The Cambridge filter method, as adopted by the Commission in", + "1967 and employed continuously since then, has provided a re-", + "liable means for decexmining the relative \"tar\" and nicotine", + "ranking of cigarettes regardless of whether they were filter,", + "nonfilter, or ventilated cigarettes. Based on the record, we", + "endorse the retention of the Cambridge filter method currently", + "employed by the FTC for \"tar\" and nicotine testing as well as", + "the format for reporting test results for all cigarettes and", + "we suggest that any proposed change based upon smoker behavior", + "or the \"tar\" presumably inhaled by human smokers is contrary", + "to the basic purpose of the test program.", + "Nevertheless, the Commission has determined that", + "the Cambridge filter methodology for testing \"tar\". nicotine", + "and carbon monoxide \"docs not measure accurately Barclay", + "MNATPRIV00028679", + "et al." + ] + }, + { + "bbox": [ + [ + 0.568618, + 0.083182, + 0.008693, + 0.010312 + ], + [ + 0.283009, + 0.108467, + 0.570798, + 0.013992 + ], + [ + 0.28235, + 0.133868, + 0.549193, + 0.012586 + ], + [ + 0.281106, + 0.159169, + 0.580807, + 0.012951 + ], + [ + 0.282779, + 0.184689, + 0.580672, + 0.013133 + ], + [ + 0.282083, + 0.208468, + 0.571116, + 0.014081 + ], + [ + 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Given the Commission's", + "determination, we believe that the proposed holder contain-", + "ing a ring of foam rubber which would abut the mouth end of", + "the cigarette and block the \"exit channels\" on the Sarclay", + "type filter would be preferable. The use of that holder,", + "while it would be more complex and more expensive and would", + "require special cleaning procedures as compared with the use", + "of the present holder, should be relatively easy to implement", + "and, in our view, would give results properly comparable to", + "results of tests of other brands using the present holder.", + "Thus, if the present holder were to continue to be used for", + "cigarettes which do not have the Actron filter utilized in", + "Barclay and the foam ring type holder were to be used for", + "Actron filter cigarettes, a source of perceived error would", + "be eliminated, while the continuity of comparative results", + "for other products would be maintained.", + "Ventilated filter cigarettes have become increasingly", + "acceptable to the smoking public. A majority of filter ciga-", + "rettes today dilute smoke with air within the filter by use", + "of a band of perforated holes in the filter. The band of", + "perforations in the filter is positioned far enough away from", + "the mouth end of the filter to allow the cigarette to be inserted", + "in the mouth without blocking the holes and far enough away from", + "the tobacco end of the filter so that the holes are not normally", + "blocked by the fingers. Thus, unlike the Actron filter utilized", + "in Barclay cigarettes, the air channels of which are incvitably", + "MNATPRIV00028670", + "Subject to Claims of Privilege and Confidentiality: Morris,", + "et", + "al." + ] + }, + { + "bbox": [ + [ + 0.576886, + 0.072394, + 0.009145, + 0.010055 + ], + [ + 0.291849, + 0.097142, + 0.574793, + 0.013061 + ], + [ + 0.290876, + 0.12204, + 0.564465, + 0.013835 + ], + [ + 0.289821, + 0.146543, + 0.255061, + 0.014127 + ], + [ + 0.389384, + 0.18417, + 0.496657, + 0.013475 + ], + [ + 0.289116, + 0.209354, + 0.585796, + 0.013192 + ], + [ + 0.288855, + 0.234693, + 0.576026, + 0.013905 + ], + [ + 0.28964, + 0.260127, + 0.554636, + 0.013831 + ], + [ + 0.289118, + 0.285024, + 0.563365, + 0.014324 + ], + [ + 0.287096, + 0.31144, + 0.559519, + 0.011677 + ], + [ + 0.287835, + 0.3366, + 0.608073, + 0.013403 + ], + [ + 0.286398, + 0.362143, + 0.568062, + 0.0131 + ], + [ + 0.287123, + 0.387011, + 0.598233, + 0.011238 + ], + [ + 0.287077, + 0.412452, + 0.598874, + 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"text": [ + "3", + "and unavoidably blocked, the usual cigarette by", + "perforations can be smoked in the ordinary course without", + "blocking the perforations.", + "The study of smoker's compensatory behavio: should", + "not be relevant to test methodology. The Commission in an-", + "nouncing its formal cigarette testing program in July 1967", + "stated: \"The purpose of testing is not to determine the", + "amount of 'tar' and nicotine inhaled by any human smoker,", + "but rather to determine the amount of 'tar' and nicotine", + "generated when a cigarette is smoked by machine in accordance", + "with the prescribed method. To attempt to devise a test", + "method that takes into account how different consumers smoke", + "ventilated filter cigarettes or other smoker behavioral pat-", + "terns, compensatory or otherwise, would require the establish-", + "ment of some sort of average smoker behavior profile. Such", + "a profile would be misleading in its apparent simplicity be-", + "cause it could not include all the variables. In short,", + "a", + "test cannot replicate human smoking and should not purport", + "to do so. The present Cambridge filter test method, whether", + "or not the Commission determines to modify its method of test-", + "ing Barclay and similar Actron filter cigarettes, gives accu-", + "rate and adequate comparative results for cigarettes ventilated", + "by perforations and no study of individual smoking behavior is", + "relevant to the test methodology.", + "Systems of grouping \"tar\" levels into categories", + "instead of reporting specific results for each product should", + "be rejected. Since 1967 consumers in this country have been", + "MNATPRIV00028677", + "Subject to Claims of Privilege and Confidentiality:", + "Produces Pursuant to in Philip Morris, et al." + ] + }, + { + "bbox": [ + [ + 0.588157, + 0.062547, + 0.018216, + 0.010237 + ], + [ + 0.300539, + 0.08691, + 0.586536, + 0.013032 + ], + [ + 0.299811, + 0.111875, + 0.606753, + 0.011992 + ], + [ + 0.300024, + 0.140423, + 0.010006, + 0.008625 + ], + [ + 0.32068, + 0.136463, + 0.575344, + 0.014621 + ], + [ + 0.299474, + 0.161539, + 0.587024, + 0.012549 + ], + [ + 0.298598, + 0.186755, + 0.597741, + 0.012902 + ], + [ + 0.29946, + 0.212118, + 0.57651, + 0.0136 + ], + [ + 0.298918, + 0.236786, + 0.575966, + 0.014303 + ], + [ + 0.297839, + 0.262591, + 0.608547, + 0.012726 + ], + [ + 0.296835, + 0.287673, + 0.607518, + 0.013038 + ], + [ + 0.29752, + 0.312024, + 0.605627, + 0.013725 + ], + [ + 0.297262, + 0.337923, + 0.598053, + 0.013298 + ], + [ + 0.29722, + 0.36227, + 0.611418, + 0.013428 + ], + [ + 0.296905, + 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to a 10 mg brand. Ciga-", + "rettes are produced with \"tar\" levels that reflect consumer", + "demands. In this country where specific numerical test data", + "is reported, average \"tar\" yields have declined from 27 mg", + "to less than 13 mg since 1960 and approximately 478 of all", + "brands are at the 10 mg level or less. In the United Kingdom", + "where a system of categories has been in place, only 24.3% of", + "all brands fall into the 10 mg or less category and more sig-", + "nificantly, 80% of those brands are clustered in the 8 mg to", + "10 mg range, or the upper limit of that category. These dif-", + "ferences in demand speak for themselves and we suggest that a", + "change in reporting is neither necessary nor desirable.", + "MNATPRIV00028678", + "Subject to Claims of Privilege and Confidentiality:", + "Produced Purcuant to Court Orders in State of Minnesota, et al.x. Philip Morris, et al." + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004300.json b/doc_00004300.json new file mode 100644 index 0000000000000000000000000000000000000000..db853a67b85e58f4ccc3864602a864814033ff07 --- /dev/null +++ b/doc_00004300.json @@ -0,0 +1,1220 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.132261, + 0.109482, + 0.129229, + 0.011629 + ], + [ + 0.132388, + 0.13554, + 0.038006, + 0.009108 + ], + [ + 0.300803, + 0.135294, + 0.121171, + 0.009861 + ], + [ + 0.132327, + 0.146769, + 0.033949, + 0.009639 + ], + [ + 0.301066, + 0.146407, + 0.219828, + 0.011274 + ], + [ + 0.13226, + 0.158907, + 0.021357, + 0.008704 + ], + [ + 0.301436, + 0.158366, + 0.137313, + 0.008863 + ], + [ + 0.132839, + 0.170002, + 0.053109, + 0.011438 + ], + [ + 0.300682, + 0.169494, + 0.306575, + 0.011422 + ], + [ + 0.50184, + 0.312219, + 0.122618, + 0.016352 + ], + [ + 0.468119, + 0.333065, + 0.188932, + 0.016582 + ], + [ + 0.475309, + 0.353226, + 0.17556, + 0.016209 + ], + [ + 0.534216, 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I", + "am\"?", + "Do you ask yourself these questions?", + "The Leadership Resources and Tools Web-site provides tools and resources to help you \"know where you", + "are\" as a leader. By accessing the site, you will find:", + "The Leadership Development Scorecard - a tool and process for upward feedback", + "1", + "PM3001121105", + "3001121105", + "3001121105", + "Source: https://www.industrydocuments.ucsf.edu/docs/fpjn0218" + ] + }, + { + "bbox": [ + [ + 0.057907, + 0.95927, + 0.090976, + 0.010738 + ], + [ + 0.150531, + 0.241442, + 0.698921, + 0.014561 + ], + [ + 0.145937, + 0.25793, + 0.709078, + 0.015062 + ], + [ + 0.135477, + 0.308142, + 0.729533, + 0.015188 + ], + [ + 0.172033, + 0.324975, + 0.657981, + 0.014719 + ], + [ + 0.30057, + 0.098929, + 0.407463, + 0.014575 + ], + [ + 0.302543, + 0.117906, + 0.530291, + 0.015388 + ], + [ + 0.302446, + 0.134887, + 0.260445, + 0.015424 + ], + [ + 0.19552, + 0.180346, + 0.511514, + 0.018125 + ], + [ + 0.42807, + 0.221039, + 0.119756, + 0.017745 + ], + [ + 0.408267, + 0.275169, + 0.184045, + 0.011061 + ], + [ + 0.447867, + 0.342438, + 0.104297, + 0.013727 + ], + [ + 0.226292, + 0.980898, + 0.547453, + 0.016404 + ], + [ + 0.498803, + 0.847761, + 0.007272, + 0.007674 + ], + [ + 0.754016, + 0.898557, + 0.1519, + 0.014644 + ], + [ + 0.805988, + 0.921937, + 0.115006, + 0.013211 + ] + ], + "poly": [ + [ + { + "X": 0.057907, + "Y": 0.95927 + }, + { + "X": 0.148883, + "Y": 0.95927 + }, + { + "X": 0.148883, + "Y": 0.970008 + }, + { + "X": 0.057907, + "Y": 0.970008 + } + ], + [ + { + "X": 0.150531, + "Y": 0.241442 + }, + { + "X": 0.849451, + "Y": 0.241442 + }, + { + "X": 0.849451, + "Y": 0.256003 + }, + { + "X": 0.150531, + "Y": 0.256003 + } + ], + [ + { + "X": 0.145937, + "Y": 0.25793 + }, + { + "X": 0.855016, + "Y": 0.25793 + }, + { + "X": 0.855016, + "Y": 0.272992 + }, + { + "X": 0.145937, + "Y": 0.272992 + } + ], + [ + { + "X": 0.135477, + "Y": 0.308142 + }, + { + "X": 0.86501, + "Y": 0.308142 + }, + { + "X": 0.86501, + "Y": 0.32333 + }, + { + "X": 0.135477, + "Y": 0.32333 + } + ], + [ + { + "X": 0.172033, + "Y": 0.324975 + }, + { + "X": 0.830014, + "Y": 0.324975 + }, + { + "X": 0.830014, + "Y": 0.339694 + }, + { + "X": 0.172033, + "Y": 0.339694 + } + ], + [ + { + "X": 0.30057, + "Y": 0.098929 + }, + { + "X": 0.708033, + "Y": 0.098929 + }, + { + "X": 0.708033, + "Y": 0.113503 + }, + { + "X": 0.30057, + "Y": 0.113503 + } + ], + [ + { + "X": 0.302543, + "Y": 0.117906 + }, + { + "X": 0.832835, + "Y": 0.117906 + }, + { + "X": 0.832835, + "Y": 0.133294 + }, + { + "X": 0.302543, + "Y": 0.133294 + } + ], + [ + { + "X": 0.302446, + "Y": 0.134887 + }, + { + "X": 0.562891, + "Y": 0.134887 + }, + { + "X": 0.562891, + "Y": 0.150311 + }, + { + "X": 0.302446, + "Y": 0.150311 + } + ], + [ + { + "X": 0.19552, + "Y": 0.180346 + }, + { + "X": 0.707035, + "Y": 0.180346 + }, + { + "X": 0.707035, + "Y": 0.19847 + }, + { + "X": 0.19552, + "Y": 0.19847 + } + ], + [ + { + "X": 0.42807, + "Y": 0.221039 + }, + { + "X": 0.547826, + "Y": 0.221039 + }, + { + "X": 0.547826, + "Y": 0.238784 + }, + { + "X": 0.42807, + "Y": 0.238784 + } + ], + [ + { + "X": 0.408267, + "Y": 0.275169 + }, + { + "X": 0.592312, + "Y": 0.275169 + }, + { + "X": 0.592312, + "Y": 0.286229 + }, + { + "X": 0.408267, + "Y": 0.286229 + } + ], + [ + { + "X": 0.447867, + "Y": 0.342438 + }, + { + "X": 0.552164, + "Y": 0.342438 + }, + { + "X": 0.552164, + "Y": 0.356165 + }, + { + "X": 0.447867, + "Y": 0.356165 + } + ], + [ + { + "X": 0.226292, + "Y": 0.980898 + }, + { + "X": 0.773745, + "Y": 0.980898 + }, + { + "X": 0.773745, + "Y": 0.997301 + }, + { + "X": 0.226292, + "Y": 0.997301 + } + ], + [ + { + "X": 0.498803, + "Y": 0.847761 + }, + { + "X": 0.506075, + "Y": 0.847761 + }, + { + "X": 0.506075, + "Y": 0.855435 + }, + { + "X": 0.498803, + "Y": 0.855435 + } + ], + [ + { + "X": 0.754016, + "Y": 0.898557 + }, + { + "X": 0.905916, + "Y": 0.898557 + }, + { + "X": 0.905916, + "Y": 0.913202 + }, + { + "X": 0.754016, + "Y": 0.913202 + } + ], + [ + { + "X": 0.805988, + "Y": 0.921937 + }, + { + "X": 0.920994, + "Y": 0.921937 + }, + { + "X": 0.920994, + "Y": 0.935149 + }, + { + "X": 0.805988, + "Y": 0.935149 + } + ] + ], + "score": [ + 0.7583, + 0.999, + 0.9984, + 0.9994, + 0.9989, + 0.9941, + 0.998, + 0.9989, + 0.7143, + 0.9968, + 0.9724, + 0.9887, + 0.7639, + 0.9928, + 0.993, + 0.9909 + ], + "text": [ + "3001121106", + "In the next few weeks, you will also be receiving a link to our enhanced Leadership Model", + "360-degree feedback instrument, developed and administered in conjunction with Personnel", + "The decision to use these feedback tools is yours. Either option provides you an opportunity to", + "see how others view your leadership effectiveness and can be important input to your", + "Tips and ideas for giving and receiving feedback effectively", + "Additional resources to assist you in hosting feedback meetings and using the", + "information to develop an action plan", + "ittp://home.pmu.com/hr/career/leadership/default.asp", + "Coming Soon", + "Decisions International.", + "development.", + "Source: :ttps://www.industrydocuments.ucsf.edu/docs/fpjn0218", + "2", + "PM3001121106", + "3001121106" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004301.json b/doc_00004301.json new file mode 100644 index 0000000000000000000000000000000000000000..cec028c580cd990cf08d507449325dfb93e6c099 --- /dev/null +++ b/doc_00004301.json @@ -0,0 +1,1308 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.108828, + 0.10989, + 0.257092, + 0.017027 + ], + [ + 0.527994, + 0.110732, + 0.180375, + 0.015663 + ], + [ + 0.109582, + 0.148387, + 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Chung", + "DATE: Oct. 3, 1993", + "DEPARTTMENTT: Technical Support", + "NOTEBOOK PAGES: 442768-9", + "356809", + "DIVISION: Analytical Chemistry", + "NO. OF PAGES: 3", + "ACD HLC 1993, 276", + "PREVIOUS REPORTS: None", + "CLIENT: Ms. D. S. Myers", + "DIVISION: Quality Assurance", + "PROGRAM: Services to QA", + "MANHOURS: 21", + "805", + "ANALYSIS OF CENTURY 100 CIGARETTES (93-180)", + "OBJECTIVE:", + "The purpose of this study was to analyze and compare the customer complaint", + "cigarettes with the control cigarettes.", + "SUMMARY:", + "Two customer complaint cigarette samples, CENTURY 100 Light and CENTURY", + "100 (93-180), were submitted by Larry Barger. The customer claimed that \"the cigarettes", + "tasted sweet\". The complaint cigarettes were analyzed by GC/MS following solvent", + "extraction. Control CENTURY 100 Light and CENTURY 100 cigarettes were analyzed", + "in the same manner for comparison. No significant differences in compounds were found", + "qualitatively and quantitatively between the complaint and the control cigarettes for both", + "samples.", + "STATUS:", + "This study is complete.", + "KEYWORDS:", + "536", + "1" + ] + }, + { + "bbox": [ + [ + 0.107164, + 0.112127, + 0.779172, + 0.01371 + ], + [ + 0.10886, + 0.130354, + 0.777282, + 0.014582 + ], + [ + 0.106959, + 0.148938, + 0.779196, + 0.016612 + ], + [ + 0.106594, + 0.168203, + 0.112574, + 0.015352 + ], + [ + 0.491686, + 0.906725, + 0.010021, + 0.010386 + ] + ], + "poly": [ + [ + { + "X": 0.107164, + "Y": 0.112127 + }, + { + "X": 0.886336, + "Y": 0.112127 + }, + { + "X": 0.886336, + "Y": 0.125837 + }, + { + "X": 0.107164, + "Y": 0.125837 + } + ], + [ + { + "X": 0.10886, + "Y": 0.130354 + }, + { + "X": 0.886142, + "Y": 0.130354 + }, + { + "X": 0.886142, + "Y": 0.144937 + }, + { + "X": 0.10886, + "Y": 0.144937 + } + ], + [ + { + "X": 0.106959, + "Y": 0.148938 + }, + { + "X": 0.886155, + "Y": 0.148938 + }, + { + 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cigarette of both complaint brands was dissolved in 20 ml of", + "ethanol and mechanically shaken for an hour. The ethanol solution was filtered and", + "concentrated to approximately 0.2 ml. A small amount (2 ul) of the solution was used for", + "analysis by GC/MS. The control cigarettes were analyzed in the same manner. A 60 m", + "X 0.25 mm ID (0.25 um film thickness) DB-1701 fused silica capillary column was used", + "for compound separation. The GC oven temperature was held at 35°C for 10 minutes,", + "programmed to 2:20°C at 3°C/min and held for 108 minutes. The mass spectrometer was", + "operated at 70 eV in the El mode. The mass range was scanned from 29-500 atomic mass", + "units. The compounds were identified by mass spectra.", + "3", + "1956" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004302.json b/doc_00004302.json new file mode 100644 index 0000000000000000000000000000000000000000..7f6c5c03389c3a37a399f72aa696de63f2783daa --- /dev/null +++ b/doc_00004302.json @@ -0,0 +1,30084 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.144631, + 0.099509, + 0.307006, + 0.059808 + ], + [ + 0.325659, + 0.146774, + 0.12267, + 0.012203 + ], + [ + 0.614116, + 0.161807, + 0.095739, + 0.009775 + ], + [ + 0.612933, + 0.175451, + 0.17976, + 0.012156 + ], + [ + 0.614114, + 0.189276, + 0.180224, + 0.010979 + ], + [ + 0.612438, + 0.20251, + 0.093833, + 0.009691 + ], + [ + 0.145564, + 0.229686, + 0.135465, + 0.014165 + ], + [ + 0.144467, + 0.28421, + 0.153216, + 0.016424 + ], + [ + 0.14421, + 0.356988, + 0.033421, + 0.012632 + ], + [ + 0.263017, + 0.356545, + 0.136476, + 0.015485 + ], + [ + 0.496507, + 0.356572, + 0.141948, + 0.01324 + ], + [ + 0.26218, + 0.374499, + 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ELLEGATE", + "Area Manager - Operations", + "Winston-Salem, NC 27102", + "910-741-5760", + "SENT VIA FAX", + "January 15, 1996", + "TO:", + "L.W. Harbaugh", + "R. J. Schweitzer", + "J. M. Lanterna", + "W. E. Surman", + "FROM:", + "J.J. Ellegate", + "SUBJECT: Work Plan Status", + "Attached please find the most recent status of product and support material", + "orders for Q1 promotions on a Sales Area level for your review.", + "I am particularly concerned with the status of our DPC orders. Please submit", + "your planned implementation schedule for First Quarter DPC promotions", + "by close of business on Friday, January 17. 1997.", + "Feel free to call with any questions.", + "Best regards,", + "John", + "J.J. Ellegate", + "JJE/bb", + "Attachment", + "CC:", + "T. S. Hartman", + "B.J. Pearson", + "A. R. James", + "D. R. Williams", + "WP.doc", + "Source: https://www.industrydocuments.ucsf.edu/docs/gryy0188" + ] + }, + { + "bbox": [ + [ + 0.469267, + 0.019697, + 0.092811, + 0.019508 + ], + [ + 0.883212, + 0.042018, + 0.070768, + 0.012851 + ], + [ + 0.053563, + 0.074734, + 0.033157, + 0.011416 + ], + [ + 0.177354, + 0.074147, + 0.049113, + 0.011525 + ], + [ + 0.510247, + 0.073099, + 0.035874, + 0.013333 + ], + [ + 0.635071, + 0.073817, + 0.048396, + 0.011376 + ], + [ + 0.053905, + 0.09018, + 0.053229, + 0.011419 + ], + [ + 0.177647, + 0.089302, + 0.225659, + 0.013663 + ], + [ + 0.511328, + 0.089406, + 0.053814, + 0.011663 + ], + [ + 0.593464, + 0.088899, + 0.251977, + 0.013984 + ], + [ + 0.053336, + 0.105324, + 0.146142, + 0.01456 + ], + [ + 0.510844, + 0.104711, + 0.08398, + 0.014042 + ], + [ + 0.635492, + 0.1046, + 0.063086, + 0.013873 + ], + [ + 0.131955, + 0.120883, + 0.017128, + 0.012916 + ], + [ + 0.205265, + 0.120634, + 0.022972, + 0.012861 + ], + [ + 0.278503, + 0.120256, + 0.037134, + 0.012307 + 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"Revised Deck Sent", + "Expecting materials for the following this week:", + "DC Extreme Sweepstakes", + "Teen People \"Whacko Wave\" Sweepstakes", + "Seventeen Summer Splash in-book listing", + "98 Degrees Contract", + "Web banners (98degrees.com, wwf.com)", + "TV Creative Rotation Schedule", + "TIW Illustrations", + "Parent Print Campaign", + "Surgeon General's Warning Edits", + "Awaiting signoff on Estimates/ATB", + "Items we owe you:", + "YSPP Brochure revision & letterhead (this week)", + "Parent Print Campaign - revised text treatment (this week)", + "Updated program executive summary and full deck (this week, awaiting PR", + "approval)", + "Source: https://www.industrydocuments.ucsf.edu/docs/jhdd0006" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004304.json b/doc_00004304.json new file mode 100644 index 0000000000000000000000000000000000000000..aedcf5a93c2253cdbec91a190f6fff6a516031f0 --- /dev/null +++ b/doc_00004304.json @@ -0,0 +1,482 @@ +{ + "pages": [ + { + 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(728-F). xHe seems like another", + "Hegsted, with no real support or ideas or savvy or aggressiveness.", + "Source: https://www.industrydocuments.ucsf.edu/docs/hhfw0229" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004305.json b/doc_00004305.json new file mode 100644 index 0000000000000000000000000000000000000000..493b169d50049749ff96651e92d7c63d5eca33ea --- /dev/null +++ b/doc_00004305.json @@ -0,0 +1,1054 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.142076, + 0.048549, + 0.139292, + 0.017108 + ], + [ + 0.406929, + 0.089888, + 0.185274, + 0.010479 + ], + [ + 0.397081, + 0.104325, + 0.203974, + 0.012306 + ], + [ + 0.461355, + 0.118649, + 0.085049, + 0.011872 + ], + [ + 0.034247, + 0.132842, + 0.899895, + 0.012571 + ], + [ + 0.034665, + 0.14718, + 0.853977, + 0.012502 + ], + [ + 0.035205, + 0.161341, + 0.57394, + 0.012773 + ], + [ + 0.046695, + 0.196044, + 0.108675, + 0.021918 + ], + [ + 0.044717, + 0.224199, + 0.122276, + 0.016521 + ], + [ + 0.047737, + 0.25271, + 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Its contents include", + "important information from the Site Director and the Leadership Team and it is for internal use only. All employees are", + "responsible for reading and understanding the information within this document.", + "S ........ Stop", + "T 3000000 Think", + "O", + "- Observe", + "P", + "- Plan", + "Accidents:", + "3/5/12 - 11:40pm - Employee sustained cut while handling pallet.", + "3/5/12 - 9:35am - PLM dropped part on ankle causing small bruise.", + "Quality / Regulatory:", + "FDA Surveillance: Post Drug-Approval Activities", + "A vital part of FDA's Center for Drug Evaluation and Research's mission is to monitor the safety and effectiveness of drugs that", + "are currently available to the American people. To meet this goal, FDA has in place postmarketing programs that monitor", + "marketed human medical products for unexpected adverse events. These programs alert the Agency to potential threats to the", + "public health. Agency experts then identify the need for preventive actions, such as changes in product labeling information and,", + "rarely, re-evaluation of an approval decision.", + "Quality Scramble:", + "cckeh (and)", + "Security:", + "For the month of February the Hobart site generated 3.46 tons of Haz Waste and 772 lbs. of Non RCRA / Non Haz wastes.", + "Attainment:", + "Packaging is waiting for the conditional release of the Phrenlin Forte to package on 162 and 12C 5 is finishing up the", + "Methadone and will then be down for work on the door, Liquids continues to investigate the rings in the formulations tanks.", + "Tableting has one press down while adjustments are made and the HVP is starting the AZO clean.", + "Dispensing is in good shape and Blending is moving ahead on the HSG/FBD as there is no more CP on site for the Tussicaps", + "granulations to continue.", + "OHC:", + "The next Blood Pressure Clinic is scheduled for Tuesday March 13th in the 12C cafeteria from 8:30 am to 9:30 am and in", + "Building 16 from 10:00 am to 11:00 am. Earn $5.00 Covidien Cash!", + "Did You Know:", + "March was the beginning of the calendar year until 1752 when the Gregorian calendar was adopted.", + "Source: https://www.industrydocuments.ucsf.edu/docs/gscm0253", + "MNKOI 0006202121" + ] + } + ] +} \ No newline at end of file diff --git a/doc_00004306.json b/doc_00004306.json new file mode 100644 index 0000000000000000000000000000000000000000..7e4c3479666420e131af129b6118c6eb6559d84b --- /dev/null +++ b/doc_00004306.json @@ -0,0 +1,352 @@ +{ + "pages": [ + { + "bbox": [ + [ + 0.058999, + 0.047805, + 0.058165, + 0.011161 + ], + [ + 0.058896, + 0.066753, + 0.0394, + 0.009412 + ], + [ + 0.164641, + 0.066409, + 0.559617, + 0.011418 + ], + [ + 0.058372, + 0.081627, + 0.034517, + 0.009549 + ], + [ + 0.164684, + 0.080965, + 0.160755, + 0.012004 + ], + [ + 0.057768, + 0.09702, + 0.021723, + 0.009185 + ], + [ + 0.165898, + 0.096622, + 0.238314, + 0.011573 + ], + [ + 0.058063, + 0.111749, + 0.05488, + 0.011501 + ], + [ + 0.164446, + 0.112113, + 0.228982, + 0.009518 + ], + [ + 0.057724, + 0.127072, + 0.373374, + 0.009755 + ], + [ + 0.058853, + 0.178372, + 0.259371, + 0.009243 + ], + [ + 0.218851, + 0.981194, + 0.562515, + 0.016498 + ], + [ + 0.818733, + 0.985609, + 0.149765, + 0.010801 + ] + ], + "poly": [ + [ + { + "X": 0.058999, + "Y": 0.047805 + }, + { + "X": 0.117164, + "Y": 0.047805 + }, + { + "X": 0.117164, + "Y": 0.058966 + }, + { + "X": 0.058999, + "Y": 0.058966 + } + ], + [ + { + "X": 0.058896, + "Y": 0.066753 + }, + { + "X": 0.098296, + "Y": 0.066753 + }, + { + "X": 0.098296, + "Y": 0.076165 + }, + { + "X": 0.058896, + "Y": 0.076165 + } + ], + [ + { + "X": 0.164641, + "Y": 0.066409 + }, + { + "X": 0.724258, + "Y": 0.066409 + }, + { + "X": 0.724258, + "Y": 0.077827 + }, + { + "X": 0.164641, + "Y": 0.077827 + } + ], + [ + { + "X": 0.058372, + "Y": 0.081627 + }, + { + "X": 0.092889, + "Y": 0.081627 + }, + { + "X": 0.092889, + "Y": 0.091177 + }, + { + "X": 0.058372, + "Y": 0.091177 + } + ], + [ + { + "X": 0.164684, + "Y": 0.080965 + }, + { + "X": 0.325439, + "Y": 0.080965 + }, + { + "X": 0.325439, + "Y": 0.092969 + }, + { + "X": 0.164684, + "Y": 0.092969 + } + ], + [ + { + "X": 0.057768, + "Y": 0.09702 + }, + { + "X": 0.079491, + "Y": 0.09702 + }, + { + "X": 0.079491, + "Y": 0.106205 + }, + { + "X": 0.057768, + "Y": 0.106205 + } + ], + [ + { + "X": 0.165898, + "Y": 0.096622 + }, + { + "X": 0.404212, + "Y": 0.096622 + }, + { + "X": 0.404212, + "Y": 0.108195 + }, + { + "X": 0.165898, + "Y": 0.108195 + } + ], + [ + { + "X": 0.058063, + "Y": 0.111749 + }, + { + "X": 0.112943, + "Y": 0.111749 + }, + { + "X": 0.112943, + "Y": 0.12325 + }, + { + "X": 0.058063, + "Y": 0.12325 + } + ], + [ + { + "X": 0.164446, + "Y": 0.112113 + }, + { + "X": 0.393428, + "Y": 0.112113 + }, + { + "X": 0.393428, + "Y": 0.121631 + }, + { + "X": 0.164446, + "Y": 0.121631 + } + ], + [ + { + "X": 0.057724, + "Y": 0.127072 + }, + { + "X": 0.431098, + "Y": 0.127072 + }, + { + "X": 0.431098, + "Y": 0.136827 + }, + { + "X": 0.057724, + "Y": 0.136827 + } + ], + [ + { + "X": 0.058853, + "Y": 0.178372 + }, + { + "X": 0.318225, + "Y": 0.178372 + }, + { + "X": 0.318225, + "Y": 0.187615 + }, + { + "X": 0.058853, + "Y": 0.187615 + } + ], + [ + { + "X": 0.218851, + "Y": 0.981194 + }, + { + "X": 0.781366, + "Y": 0.981194 + }, + { + "X": 0.781366, + "Y": 0.997692 + }, + { + "X": 0.218851, + "Y": 0.997692 + } + ], + [ + { + "X": 0.818733, + "Y": 0.985609 + }, + { + "X": 0.968499, + "Y": 0.985609 + }, + { + "X": 0.968499, + "Y": 0.99641 + }, + { + "X": 0.818733, + "Y": 0.99641 + } + ] + ], + "score": [ + 0.9976, + 0.9982, + 0.7482, + 0.9878, + 0.5437, + 0.9979, + 0.9668, + 0.9895, + 0.9691, + 0.9903, + 0.9945, + 0.9569, + 0.9791 + ], + "text": [ + "Message", + "From:", + "orddist.S0400003@MALLINCKRODT.COM [orddist.S0400003@MALLINCKRODT.COM", + "Sent:", + "12/23/2015 1:23:00 AM", + "To:", + "eileen.spaulding@mallinckrodt.com", + "Subject:", + "222 CLEARING RPT - HOBART - ALL", + "Attachments: 222 CLEARING RPT - HOBART 122215.xls", + "222 CLEARING RPT - HOBART - ALL", + "Source: https://www.industrydocuments.ucsf.edu/docs/jpbd0248", + "MNKOI 0004418827" + ] + } + ] +} \ No newline at end of file