#!/usr/bin/env python3 # Copyright (c) Meta Platforms, Inc. and affiliates. # All rights reserved. # # OpenAI tool-calling agent for pathway_analysis_env (in-process orchestrator). # # Usage: # export OPENAI_API_KEY=... # PYTHONPATH=src:envs uv run python examples/pathway_agent_loop.py \ # --case toy_case_001.json from __future__ import annotations import argparse import asyncio import json import os import sys from pathway_analysis_env.agent_openai_tools import ( OPENAI_TOOLS, observation_to_tool_result_content, tool_call_to_pathway_action, ) from pathway_analysis_env.models import PathwayAction from pathway_analysis_env.server.pathway_environment import PathwayEnvironment SYSTEM_PROMPT = """You are a computational biologist agent operating a pathway analysis environment. Required workflow (eval mode): 1. understand_experiment_design and/or inspect_dataset — learn groups and sample layout. 2. run_differential_expression — set reference (baseline) vs alternate (treatment) conditions. 3. run_pathway_enrichment — ORA on DE genes (do not pass a custom gene_list). 4. Optionally compare_pathways between two top pathway names. 5. submit_answer — one pathway hypothesis string supported by ORA. Rules: - Never guess without running DE and ORA first. - Use condition names exactly as returned in available_conditions. - For submit_answer, name a specific pathway (e.g. from top_pathways), not a long essay. """ async def run_episode( case_file: str, model: str, max_turns: int, *, strict: bool, ) -> dict: try: from openai import AsyncOpenAI except ImportError as exc: raise SystemExit("Install openai: uv add openai") from exc if not os.environ.get("OPENAI_API_KEY"): print("Warning: OPENAI_API_KEY not set", file=sys.stderr) client = AsyncOpenAI() env = PathwayEnvironment(case_file=case_file) obs = env.reset(orchestrator_mode=True, strict=strict) messages = [ {"role": "system", "content": SYSTEM_PROMPT}, { "role": "user", "content": ( f"Episode started for case {case_file}. " f"Conditions: {obs.available_conditions}. " f"{obs.message}" ), }, ] for turn in range(max_turns): response = await client.chat.completions.create( model=model, messages=messages, tools=OPENAI_TOOLS, tool_choice="auto", ) msg = response.choices[0].message if not msg.tool_calls: messages.append({"role": "assistant", "content": msg.content or ""}) if env.state.is_done: break continue messages.append(msg.model_dump()) for tc in msg.tool_calls: action = tool_call_to_pathway_action( name=tc.function.name, arguments_json=tc.function.arguments, ) step_obs = env.step(action) messages.append( { "role": "tool", "tool_call_id": tc.id, "content": observation_to_tool_result_content(step_obs), } ) if step_obs.done: return { "turns": turn + 1, "done": True, "episode_outcome": env.episode_outcome, "last_message": step_obs.message, "steps": env.state.step_count, } return { "turns": max_turns, "done": env.state.is_done, "episode_outcome": env.episode_outcome, "steps": env.state.step_count, } def main() -> None: parser = argparse.ArgumentParser(description="LLM agent on pathway_analysis_env") parser.add_argument("--case", default="toy_case_001.json") parser.add_argument("--model", default="gpt-4o-mini") parser.add_argument("--max-turns", type=int, default=24) parser.add_argument("--strict", action="store_true") args = parser.parse_args() result = asyncio.run( run_episode(args.case, args.model, args.max_turns, strict=args.strict) ) print(json.dumps(result, indent=2)) outcome = result.get("episode_outcome") or {} if outcome.get("correct"): sys.exit(0) sys.exit(1 if result.get("done") else 2) if __name__ == "__main__": main()