Given the context: 'Rodent studies implicate the medial temporal lobe, especially the hippocampus, in memory and navigation, but the role of these structures in human imagination remains uncertain despite the centrality of episodic memory and imagining for human cognition.', the key idea: 'The study tests whether hippocampal theta oscillations encode spatial information similarly during real-world and imagined navigation in humans, proposing that imagination recruits navigational neural dynamics that segment routes into linear components.', the method: 'Using motion capture and intracranial electroencephalographic recordings from chronically implanted medial temporal lobe electrodes in human participants, the study analyzed hippocampal theta dynamics during actual and imagined navigation and applied a statistical model to reconstruct positions from neural data.', the outcome: 'Intermittent hippocampal theta dynamics encoded spatial information and partitioned navigational routes into linear segments during real-world navigation, and similar theta patterns occurred during imagined navigation without external cues; a statistical model successfully reconstructed both real-world and imagined positions.', and the projected impact: 'The findings provide insights into neural mechanisms of human navigation and imagination with implications for understanding memory in real-world settings, highlighting parallels among navigational, imaginative, and mnemonic processes.', predict the title of this research paper. Output only the title without explanation.

Human neural dynamics of real-world and imagined navigation


System:
You are an expert in research tasked with generating detailed prompts for various aspects of academic research papers. Each task involves creating a specific type of prompt based on the provided information. Here are the definitions of each part you will work with:

- Context: The status quo of related literature or reality which motivated this study. This could normally be a problem, a research question, or a research gap that has not been successfully addressed by previous work. This is anything that happened before this study.
- Key Idea: The main intellectual merit of this paper, often in comparison to the context. This could normally be a novel idea or solution proposed in this paper that distinguishes it from what's already done in literature. This is proposed in this study.
- Method: The specific research method that investigates and validates the key idea. This could be an experimental setup, a theoretical framework, or other necessary methodology to implement and/or evaluate the key idea. This is performed in this study.
- Outcome: The factual statement about the study output. This could be the experiment results and any other measurable outcome that has occurred. It marks whether the key hypothesis is testified or not. This is produced in this study.
- Projected Impact: The author-anticipated impact of the work on the field, and potential further research identified by the author that may improve or extend this study. This is anything being anticipated but has not happened yet.

Given the context: 'Understanding the neural basis of natural language processing in everyday conversations has lacked a unified framework linking acoustic, speech, and linguistic representations, and symbolic models have underperformed in capturing brain activity.', the key idea: 'A unified acoustic-to-speech-to-language embedding framework using Whisper connects multiple representational levels and maps them to brain activity during both speech production and comprehension.', the method: 'Electrocorticography recorded neural signals over 100 hours of open-ended conversations; low-level acoustic, mid-level speech, and contextual word embeddings from Whisper were linearly encoded to predict brain activity, with tests of generalization to new conversations and comparisons to symbolic models.', the outcome: 'The model accurately predicts neural activity across representational levels in unseen conversations, aligns its internal hierarchy with cortical speech and language regions, captures pre-articulation language-to-speech and post-articulation speech-to-language sequences, and outperforms symbolic models.', and the projected impact: 'The results support a shift toward unified computational models that encompass the full hierarchy of speech comprehension and production in real-world conversations.', predict the title of this research paper. Output only the title without explanation.

A unified acoustic-to-speech-to-language embedding space captures the neural basis of natural language processing in everyday conversations


Given the context: 'Death anxiety has long been linked to psychological distress, and prior studies suggest it may contribute transdiagnostically to mental disorders, motivating a need to quantify its association with distress and psychopathology.', the key idea: 'A comprehensive systematic review and meta-analysis quantifies the correlations between death anxiety and distress or mental disorder symptoms across general and clinical samples, while examining moderators and potential publication bias.', the method: 'The authors systematically searched multiple databases up to October 30, 2023 for studies reporting correlations between death anxiety and distress or mental disorder symptoms, using validated measures and evaluating quality with NHLBI tools. They pooled 129 studies (158 samples; 34,147 participants) and analyzed heterogeneity, prediction intervals, moderator effects, and small-study effects.', the outcome: 'Death anxiety showed consistently positive associations with general anxiety (r = 0.42), depression (r = 0.41), and distress (r = 0.36), all P < 0.001, with substantial heterogeneity and prediction intervals crossing zero except for anxiety and distress. No moderation by death anxiety measure, sample type, or proportion of women was found; associations were stronger when medical conditions were present (r = 0.48 vs. 0.37), there was evidence of small-study effects suggesting publication bias, and most included studies were rated poor quality.', and the projected impact: 'The authors recommend longitudinal studies across diverse patient samples to clarify the causal contribution of death anxiety to psychopathology.', predict the title of this research paper. Output only the title without explanation.

A meta-analysis of the association of death anxiety with psychological distress and psychopathology


Given the context: 'Voluntary stopping of speech is essential in conversation, yet the cognitive and neural mechanisms of speech inhibition are not well understood, and speech arrest during stimulation has been interpreted as evidence for production centers.', the key idea: 'A distinct premotor frontal cortical network supports inhibitory control of speech, separate from regions encoding articulatory movements.', the method: 'High-density electrocorticography recorded cortical activity during continuous speech with visual stop cues, complemented by electrocortical stimulation at premotor sites to test causality of speech arrest.', the outcome: 'Premotor frontal cortex showed distinct stop-related activity localized apart from articulatory regions and primarily during abrupt mid-utterance stopping; stimulation at these sites caused involuntary speech arrest, challenging prior clinical interpretations.', and the projected impact: 'Findings imply a revised understanding of speech motor control with implications for both natural and altered speech production.', predict the title of this research paper. Output only the title without explanation.

Inhibitory control of speech production in the human premotor frontal cortex


Given the context: 'Mentoring is crucial for scientific achievements and career success, and large research groups are often perceived as signs of exceptional mentorship and high-quality research. However, concerns exist that large, competitive groups may increase dropout rates among early-career researchers, potentially leading to postdoc shortages and loss of top-tier academics.', the key idea: 'The study investigates how a mentor’s group size influences mentees’ future academic longevity and performance using longitudinal genealogical data on mentor–mentee relations and publications.', the method: 'The authors collected and analyzed longitudinal genealogical data on mentor–mentee relationships and their publications to assess the impact of mentors’ group size on mentees’ academic survival and performance, verifying trends across institutions with different prestige levels.', the outcome: 'Mentees trained in larger groups tend to exhibit superior academic performance compared with those from smaller groups, conditional on remaining in academia post graduation. Academic survival rates are significantly lower for mentees from larger groups and for mentees with more productive mentors, with these trends consistent across institutions of varying prestige.', and the projected impact: 'The findings prompt a rethinking of effective mentorship and offer actionable insights for career advancement.', predict the title of this research paper. Output only the title without explanation.

Academic mentees thrive in big groups, but survive in small groups


Given the context: 'Higher parental age is positively associated with children's education, but whether this relationship is causal remains debated amid widespread postponement of first births in developed countries.', the key idea: 'Use Mendelian randomization with maternal and paternal polygenic indices for age at first birth, conditioning on the child's polygenic index, to identify the causal effects of parental age on children's test scores.', the method: 'An instrumental variable approach employing parental and child PGIs for age at first birth, controlling correlations among PGIs, applied to data from the Norwegian Mother, Father and Child Cohort study to assess test scores at age 10.', the outcome: 'No evidence of positive causal effects of maternal or paternal age at first birth on children's test scores at age 10 after conditioning on the child's PGI and controlling for PGI correlations.', and the projected impact: 'N/A', predict the title of this research paper. Output only the title without explanation.

No evidence of positive causal effects of maternal and paternal age at first birth on children’s test scores at age 10 years


Given the context: 'Memorability is an intrinsic stimulus property shown to be consistent across people for visual stimuli, but whether similar consistency exists for auditory stimuli like voices was unclear.', the key idea: 'The study proposes that voice memorability is consistent across listeners and can be predicted from quantifiable low-level acoustic features and high-level attributes such as dialect.', the method: 'A large-scale online recognition memory experiment collected scores from over 3,000 participants listening to speakers saying the same sentence, and regression models using low-level (e.g., fundamental frequency) and high-level (e.g., dialect) voice properties were trained and tested with out-of-sample generalization.', the outcome: 'There was significant cross-participant consistency in memory for voice clips and for speakers across different utterances, and the regression models significantly predicted memorability and generalized out of sample, with low-level acoustic features reliably predicting voice memorability.', and the projected impact: 'N/A', predict the title of this research paper. Output only the title without explanation.

The memorability of voices is predictable and consistent across listeners


Given the context: 'Adaptation has been extensively studied in motor control, but there is limited evidence that cognitive functions like working memory use similar error-driven adaptive mechanisms; the study investigates whether internal spatial representations undergo adaptation.', the key idea: 'Errors in the allocation of visual attention can drive adaptive shifts in spatial cognition, suggesting that mechanisms previously ascribed to motor adaptation also calibrate spatial cognitive representations.', the method: 'Participants completed an interleaved task with frequent perceptual discrimination trials that used an exogenous peripheral cue followed by a displaced target to induce covert attentional allocation errors, and less frequent spatial working memory trials with delayed recall, with half presented at the cue location. Multiple control experiments ruled out oculomotor confounds and attentional biases unrelated to error.', the outcome: 'Spatial recall shifted to counteract accumulated attentional errors, with shift magnitude proportional to the number of induced errors; recall performance recovered rapidly once error trials ceased, and alternative explanations were excluded by controls.', and the projected impact: 'N/A', predict the title of this research paper. Output only the title without explanation.

Errors of attention adaptively warp spatial cognition


Given the context: 'Deciphering the genetic architecture of depression is pivotal for understanding its pathophysiology and for developing new therapeutics.', the key idea: 'A cross-ancestry genome-wide meta-analysis combined with systems-level integrative analyses is used to identify risk loci, prioritize likely causal variants and genes, and nominate therapeutic targets for depression.', the method: 'A meta-analysis of 416,437 cases and 1,308,758 controls across ancestries, variant-level fine mapping, functional genomic analysis of transcription factor binding, validation of regulatory function, expression quantitative trait loci analysis, transcriptome- and proteome-wide association studies, colocalization and Mendelian randomization, pathway enrichment analyses, and mouse knockdown experiments for Tmem106b.', the outcome: 'Identified 287 risk loci including 49 new loci; prioritized potential causal variants that regulate transcription factor binding; validated that 80% of identified functional variants are regulatory; eQTL analyses uncovered potential target genes; prioritized likely causal genes including TMEM106B, CTNND1, and AREL1; depression risk genes are enriched in synapse-related pathways; Tmem106b knockdown in mice produced depression-like behaviors.', and the projected impact: 'The results provide insights into the genetic architecture of depression and highlight likely therapeutic targets, informing future translational research.', predict the title of this research paper. Output only the title without explanation.

Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression


Given the context: 'Modern economies require increasingly diverse and specialized skills, many of which depend on the acquisition of other skills first.', the key idea: 'The study reveals a nested structure within skill portfolios, inferring the direction of skill dependencies from asymmetrical conditional probabilities, indicating that advanced, specific skills build upon broader, fundamental ones.', the method: 'The authors analyze US survey data and resumes and examine 70 million job transitions, using asymmetrical conditional probabilities to infer directional skill dependencies and relate alignment with the nested structure to wages, education length, and automation risk.', the outcome: 'They identify a nested hierarchy of human capital and show that career progression follows this structure; skills more aligned with it command higher wage premiums, require longer education, and are less likely to be automated. Disparities across genders and racial/ethnic groups explain long-term wage penalties, and the nested structure has become more pronounced over the past two decades, indicating increased barriers to upward mobility.', and the projected impact: 'The nested skill structure provides insights into wage disparities and long-term wage penalties across demographic groups.', predict the title of this research paper. Output only the title without explanation.

Skill dependencies uncover nested human capital


Given the context: 'The study addresses the question of how well people judge the veracity of news.', the key idea: 'A comprehensive synthesis quantifies people's discernment between true and fact-checked false news and examines the role of political concordance in news judgments.', the method: 'A pre-registered systematic review and meta-analysis of 303 effect sizes from 67 experimental articles, including 194,438 participants across 40 countries on six continents, comparing accuracy ratings of true and fact-checked false news and testing effects of political concordance.', the outcome: 'True news was rated more accurate than false news (Cohen’s d=1.12), participants were better at rating false news as false than rating true news as true (d=0.32), political concordance did not affect discernment, and participants were more skeptical of politically discordant news (d=0.78), indicating a tendency to err on the side of skepticism.', and the projected impact: 'The results support crowdsourced fact-checking initiatives and suggest prioritizing increasing acceptance of true news over reducing acceptance of fact-checked false news to improve discernment.', predict the title of this research paper. Output only the title without explanation.

Spotting false news and doubting true news: a systematic review and meta-analysis of news judgements


Given the context: 'The study aims to investigate the relationship between socio-economic status and health disparities, focusing on the socio-economic health gradient linking income and health.', the key idea: 'Introduce a common genetic factor underlying multiple income measures (the Income Factor) and use a polygenic index to examine health associations while disentangling genetic overlap with educational attainment.', the method: 'Conduct a genome-wide association study on income in 668,288 individuals of European descent, identify genomic loci, build a polygenic index, perform a phenome-wide association study, estimate genetic correlation with educational attainment, and analyze residual genetic signals after accounting for overlap.', the outcome: 'Identified 162 income-associated loci with small effects; the polygenic index explains 1–5% of income variance with about one fourth due to direct genetic effects; the index is associated with reduced risks for hypertension, obesity, type 2 diabetes, depression, asthma, and back pain; the Income Factor shows a genetic correlation of 0.92 (s.e.=0.006) with educational attainment; residual genetic signal is linked to better mental health but reduced physical health and increased risky behaviors such as drinking and smoking.', and the projected impact: 'The findings highlight the complex genetic influences on income and health and shed light on the interplay between genetics, income, education, and health.', predict the title of this research paper. Output only the title without explanation.

Associations between common genetic variants and income provide insights about the socio-economic health gradient


Given the context: 'Understanding whether risk preference is a stable, coherent trait is central to efforts aimed at explaining, predicting and preventing risk-related behaviours.', the key idea: 'The study characterizes the risk preference construct by using a systematic review and individual participant data meta-analysis to assess temporal stability and convergent validity across many measures, domains and samples.', the method: 'A systematic review and individual participant data meta-analytic approach summarized the temporal stability of 358 risk preference measures across 33 panels, 57 samples and 579,114 respondents, examining heterogeneity by measure category (propensity, frequency, behaviour), domain and age, and analyzing convergent validity.', the outcome: 'Self-reported propensity and frequency measures show higher temporal stability than behavioural measures, with patterns moderated by domain and age; there is notable heterogeneity across and within categories, and convergent validity shows low agreement across measures, questioning whether they capture the same phenomena.', and the projected impact: 'The results raise concerns about the coherence and measurement of the risk preference construct.', predict the title of this research paper. Output only the title without explanation.

A systematic review and meta-analyses of the temporal stability and convergent validity of risk preference measures


Given the context: 'Healthcare use among adolescents after SARS-CoV-2 vaccination is unknown, motivating examination of post-vaccination healthcare utilization.', the key idea: 'Quantify and compare healthcare use in 12–18-year-olds vaccinated with Pfizer-BioNTech BNT162b2 versus age- and sex-matched unvaccinated peers using national register data and PERR estimates to assess practical significance.', the method: 'A real-life register-based cohort study matched first-dose vaccinated adolescents (1 May–30 September 2021) 1:1 by sex and age to unvaccinated adolescents and compared emergency room, hospitalization, general practitioner, and specialist visits using the prior event rate ratio (PERR).', the outcome: 'Boys had fewer GP visits after the first dose (PERR 0.93, 95% CI 0.89–0.99); up to 56 days after the second dose vaccinated boys had lower specialist visit rates (0.88, 95% CI 0.79–0.99); after 57–182 days vaccinated girls and boys had higher ER (girls 1.22, 95% CI 1.08–1.39; boys 1.17, 95% CI 1.07–1.31) and GP visit rates (girls 1.17, 95% CI 1.12–1.21; boys 1.17, 95% CI 1.13–1.22), and vaccinated boys had higher specialist visits (1.23, 95% CI 1.08–1.39), with estimates close to one indicating no practically meaningful increase in healthcare use.', and the projected impact: 'N/A', predict the title of this research paper. Output only the title without explanation.

Healthcare use in 12–18-year-old adolescents vaccinated against SARS-CoV-2 versus unvaccinated in a national register-based Danish cohort


Given the context: 'Science is crucial for evidence-based decision-making, but recent challenges to the epistemic authority of science have raised concerns about low public trust in scientists.', the key idea: 'A large preregistered global survey assesses public trust in scientists and attitudes about scientists' engagement in society and policymaking, and examines variation using individual- and country-level factors.', the method: 'A preregistered survey of 71,922 respondents across 68 countries measured trust in scientists and support for scientists' societal and policy engagement, and analyzed variations between and within countries using variables including political orientation.', the outcome: 'In most countries, most people trust scientists and agree that scientists should engage more in society and policymaking; trust is moderately high overall, with variations explained by individual- and country-level variables.', and the projected impact: 'Findings have implications for scientists and policymakers seeking to maintain and increase trust, and highlight that distrust among even a small minority may affect the consideration of scientific evidence in policymaking.', predict the title of this research paper. Output only the title without explanation.

Trust in scientists and their role in society across 68 countries


Given the context: 'Genome-wide association studies have identified multiple schizophrenia risk loci predominantly in European-ancestry populations, leaving gaps in understanding genetic risk across diverse ancestries and in pinpointing causal genes and therapeutic targets.', the key idea: 'The study leverages large-scale Eastern Asian GWAS and cross-ancestry meta-analysis, integrating variant-level and gene-level evidence to prioritize causal variants/genes and to identify potential therapeutic targets via drug repurposing.', the method: 'A GWAS in Eastern Asians (29,519 cases; 44,392 controls) followed by a cross-ancestry GWAS meta-analysis (96,806 cases; 492,818 controls), with fine mapping, functional genomics and eQTL analyses, plus TWAS, PWAS, and Mendelian randomization to nominate causal genes, and drug repurposing to identify targets.', the outcome: 'Ten Eastern Asian-specific risk loci were identified (two novel), and 61 previously unreported loci emerged from the cross-ancestry meta-analysis; integrated analyses prioritized causal genes including ACE, CNNM2, SNAP91, ABCB9, and GATAD2A, and drug repurposing highlighted ACE, CA14, MAPK3, and MAPT as potential schizophrenia therapeutic targets.', and the projected impact: 'N/A', predict the title of this research paper. Output only the title without explanation.

Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia


Given the context: 'The biology underlying how social relationships affect health is largely unknown.', the key idea: 'Characterize plasma proteomic signatures of social isolation and loneliness and test causal links to specific proteins using proteome-wide approaches, network analysis, Mendelian randomization, and colocalization.', the method: 'Leveraged UK Biobank data on 42,062 participants and 2,920 plasma proteins; conducted proteome-wide association and protein co-expression network analyses; performed Mendelian randomization with colocalization; examined prospective associations over 14 years with cardiometabolic outcomes; assessed links to other blood biomarkers and brain region volumes; and tested mediation of disease relationships.', the outcome: 'Proteins associated with social isolation and loneliness were implicated in inflammation, antiviral responses, and complement systems; over half were prospectively linked to cardiovascular disease, type 2 diabetes, stroke, and mortality; Mendelian randomization suggested causal effects from loneliness to five proteins (GFRA1, ADM, FABP4, TNFRSF10A, ASGR1), with ADM and ASGR1 supported by colocalization; these proteins showed broad associations with blood biomarkers and brain volumes; and they partly mediated the relationships between loneliness and cardiometabolic diseases, stroke, and mortality.', and the projected impact: 'Exploring peripheral physiological pathways connecting social relationships to health has potential public health implications.', predict the title of this research paper. Output only the title without explanation.

Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality


Given the context: 'Conventional cognitive control tasks typically involve a single task and one source of distraction, leaving unclear how control is allocated when multiple independent distractors are present.', the key idea: 'The study introduces a multidimensional task-set interference paradigm to examine whether control adapts by enhancing task-relevant information or suppressing task-irrelevant information, and posits distractor-specific adaptation modeled with multiple independent conflict-detector units.', the method: 'Three behavioral experiments using the new multidimensional paradigm assessed trial-by-trial adaptation to conflict across three independent distractor dimensions, complemented by neural network simulations incorporating separate conflict-detector units.', the outcome: 'Evidence shows control adapts by suppressing task-irrelevant information rather than enhancing relevant information, and this adaptation is highly dimension-specific with no generalization; the neural model reproduces results only when it includes multiple independent conflict-detector units.', and the projected impact: 'Findings call for updating classic cognitive control models and revising their neurocomputational accounts to accommodate dimension-specific control mechanisms.', predict the title of this research paper. Output only the title without explanation.

Distractor-specific control adaptation in multidimensional environments