diff --git "a/ichorbio_bsr.json" "b/ichorbio_bsr.json" new file mode 100644--- /dev/null +++ "b/ichorbio_bsr.json" @@ -0,0 +1,14898 @@ +{ + "dataset": "ichorbio Biosimilar Reference Database", + "version": "0.1.3", + "antibodies": [ + { + "entry_id": "ICB-BSR-0001", + "inn": "Adalimumab", + "target": "TNF alpha", + "target_uniprot": "P01375", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4001", + "product_url": "https://ichor.bio/adalimumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921521", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQRYNRAPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0002", + "inn": "Alemtuzumab", + "target": "CD52", + "target_uniprot": "P31358", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4002", + "product_url": "https://ichor.bio/alemtuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921522", + "sequences": { + "heavy_chain": "QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQHISRPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.58, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95.802, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 95.802% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0003", + "inn": "Bevacizumab", + "target": "VEGF", + "target_uniprot": "P15692", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH4003", + "product_url": "https://ichor.bio/bevacizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921523", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0004", + "inn": "Cetuximab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH4004", + "product_url": "https://ichor.bio/cetuximab-biosimilar-research-grade-ich4004", + "rrid": "RRID:AB_2921524", + "sequences": { + "heavy_chain": "QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.673, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.673% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0005", + "inn": "Eculizumab", + "target": "Complement protein C5", + "target_uniprot": "P01031", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2/4 kappa", + "product_sku": "ICH4005", + "product_url": "https://ichor.bio/eculizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921525", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFSNYWIQWVRQAPGQGLEWMGEILPGSGSTEYTENFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYFFGSSPNWYFDVWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCGASENIYGALNWYQQKPGKAPKLLIYGATNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLNTPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0006", + "inn": "Infliximab", + "target": "TNF alpha", + "target_uniprot": "P01375", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4006", + "product_url": "https://ichor.bio/infliximab-biosimilar-research-grade-ich4006", + "rrid": "RRID:AB_2921526", + "sequences": { + "heavy_chain": "EVKLEESGGGLVQPGGSMKLSCVASGFIFSNHWMNWVRQSPEKGLEWVAEIRSKSINSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYGSTYDYWGQGTTLTVSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DILLTQSPAILSVSPGERVSFSCRASQFVGSSIHWYQQRTNGSPRLLIKYASESMSGIPSRFSGSGSGTDFTLSINTVESEDIADYYCQQSHSWPFTFGSGTNLEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.18, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0007", + "inn": "Nimotuzumab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4008", + "product_url": "https://ichor.bio/nimotuzumab-biosimilar-research-grade-ich4008", + "rrid": "RRID:AB_2921528", + "sequences": { + "heavy_chain": "QVQLQQSGAEVKKPGSSVKVSCKASGYTFTNYYIYWVRQAPGQGLEWIGGINPTSGGSNFNEKFKTRVTITVDESTNTAYMELSSLRSEDTAFYFCARQGLWFDSDGRGFDFWGQGSTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQNIVHSNGNTYLDWYQQTPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCFQYSHVPWTFGQGTKLQITREVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0008", + "inn": "Nivolumab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 kappa", + "product_sku": "ICH4009", + "product_url": "https://ichor.bio/nivolumab-biosimilar-research-grade-ich4009", + "rrid": "RRID:AB_2921529", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.212, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.212% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0009", + "inn": "Omalizumab", + "target": "IgE", + "target_uniprot": "P01854", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4010", + "product_url": "https://ichor.bio/omalizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921530", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNWIRQAPGKGLEWVASITYDGSTNYNPSVKGRITISRDDSKNTFYLQMNSLRAEDTAVYYCARGSHYFGHWHFAVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCRASQSVDYDGDSYMNWYQQKPGKAPKLLIYAASYLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSHEDPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.17, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.868, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.868% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0010", + "inn": "Rituximab", + "target": "CD20", + "target_uniprot": "P11836", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4011", + "product_url": "https://ichor.bio/rituximab-biosimilar-research-grade", + "rrid": "RRID:AB_2921531", + "sequences": { + "heavy_chain": "QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.57, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.782, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.782% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0011", + "inn": "Tocilizumab", + "target": "IL-6 receptor", + "target_uniprot": "P08887", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4012", + "product_url": "https://ichor.bio/tocilizumab-biosimilar-research-grade-ich4012", + "rrid": "RRID:AB_2921532", + "sequences": { + "heavy_chain": "QVQLQESGPGLVRPSQTLSLTCTVSGYSITSDHAWSWVRQPPGRGLEWIGYISYSGITTYNPSLKSRVTMLRDTSKNQFSLRLSSVTAADTAVYYCARSLARTTAMDYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISSYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQGNTLPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.136, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.136% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0012", + "inn": "Trastuzumab", + "target": "HER2", + "target_uniprot": "P04626", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4013", + "product_url": "https://ichor.bio/trastuzumab-biosimilar-research-grade-ich4013", + "rrid": "RRID:AB_2921533", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, ≥95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0013", + "inn": "Trastuzumab Deruxtecan", + "target": "ERBB2 / HER2 / CD340", + "target_uniprot": "P04626", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH4013D", + "product_url": "https://ichor.bio/trastuzumab-deruxtecan-biosimilar-research-grade-ich4013d", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0014", + "inn": "Alirocumab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH4016", + "product_url": "https://ichor.bio/alirocumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921534", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFNNYAMNWVRQAPGKGLDWVSTISGSGGTTNYADSVKGRFIISRDSSKHTLYLQMNSLRAEDTAVYYCAKDSNWGNFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLYRSNNRNFLGWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYTTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0015", + "inn": "Avelumab", + "target": "PD-L1", + "target_uniprot": "Q9NZQ7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 lambda", + "product_sku": "ICH4017", + "product_url": "https://ichor.bio/avelumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921535", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYIMMWVRQAPGKGLEWVSSIYPSGGITFYADTVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARIKLGTVTTVDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.014, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.014% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0016", + "inn": "Atezolizumab", + "target": "PD-L1", + "target_uniprot": "Q9NZQ7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4018", + "product_url": "https://ichor.bio/atezolizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921536", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.005, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.005% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0017", + "inn": "Denosumab", + "target": "RANKL", + "target_uniprot": "O14788", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH4019", + "product_url": "https://ichor.bio/denosumab-biosimilar-research-grade-ich4019", + "rrid": "RRID:AB_2921537", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGITGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDPGTTVIMSWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVRGRYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVFYCQQYGSSPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.05, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0018", + "inn": "Daratumumab", + "target": "CD38", + "target_uniprot": "P28907", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4020", + "product_url": "https://ichor.bio/daratumumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921538", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.08, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0019", + "inn": "Evolocumab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH4023", + "product_url": "https://ichor.bio/evolocumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921539", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTLTSYGISWVRQAPGQGLEWMGWVSFYNGNTNYAQKLQGRGTMTTDPSTSTAYMELRSLRSDDTAVYYCARGYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "ESALTQPASVSGSPGQSITISCTGTSSDVGGYNSVSWYQQHPGKAPKLMIYEVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCNSYTSTSMVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 141.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.025, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.025% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0020", + "inn": "Ipilimumab", + "target": "CTLA-4", + "target_uniprot": "P16410", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4025", + "product_url": "https://ichor.bio/ipilimumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921540", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.989, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.989% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0021", + "inn": "Obinutuzumab", + "target": "CD20", + "target_uniprot": "P11836", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH4026", + "product_url": "https://ichor.bio/obinutuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921541", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, ≥95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0022", + "inn": "Pembrolizumab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 kappa", + "product_sku": "ICH4029", + "product_url": "https://ichor.bio/pembrolizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921544", + "sequences": { + "heavy_chain": "QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.09, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.09% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0023", + "inn": "Pertuzumab", + "target": "HER2", + "target_uniprot": "P04626", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH4030", + "product_url": "https://ichor.bio/pertuzumab-biosimilar-research-grade-ich4030", + "rrid": "RRID:AB_2921545", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 167.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.49, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0024", + "inn": "Ranibizumab", + "target": "VEGF", + "target_uniprot": "P15692", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4031", + "product_url": "https://ichor.bio/ranibizumab-biosimilar-research-grade-ich4031", + "rrid": "RRID:AB_2921546", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 167.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.28, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0025", + "inn": "Ramucirumab", + "target": "VEGFR2", + "target_uniprot": "P35968", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH4032", + "product_url": "https://ichor.bio/ramucirumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921547", + "sequences": { + "heavy_chain": "EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTDAFDIWGQGTMVTVSSASTKGPSVLPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASIGDRVTITCRASQGIDNWLGWYQQKPGKAPKLLIYDASNLDTGVPSRFSGSGSGTYFTLTISSLQAEDFAVYFCQQAKAFPPTFGGGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0026", + "inn": "Secukinumab", + "target": "IL17A", + "target_uniprot": "Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4033", + "product_url": "https://ichor.bio/secukinumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921548", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMNWVRQAPGKGLEWVAAINQDGSEKYYVGSVKGRFTISRDNAKNSLYLQMNSLRVEDTAVYYCVRDYYDILTDYYIHYWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPCTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 148.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.88, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.462, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.462% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0027", + "inn": "Ustekinumab", + "target": "IL-12 and IL-23", + "target_uniprot": "P29459", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 kappa", + "product_sku": "ICH4034", + "product_url": "https://ichor.bio/ustekinumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921549", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFTTYWLGWVRQMPGKGLDWIGIMSPVDSDIRYSPSFQGQVTMSVDKSITTAYLQWNSLKASDTAMYYCARRRPGQGYFDFWGQGTLVTVSSSSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0028", + "inn": "Vedolizumab", + "target": "Integrin alpha 4 + beta 7", + "target_uniprot": "P13612", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH4035", + "product_url": "https://ichor.bio/vedolizumab-biosimilar-research-grade-ich4035", + "rrid": "RRID:AB_2921550", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKGSGYTFTSYWMHWVRQAPGQRLEWIGEIDPSESNTNYNQKFKGRVTLTVDISASTAYMELSSLRSEDTAVYYCARGGYDGWDYAIDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLAKSYGNTYLSWYLQKPGQSPQLLIYGISNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQGTHQPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0029", + "inn": "Sintilimab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5001", + "product_url": "https://ichor.bio/sintilimab-biosimilar-research-grade-ich5001", + "rrid": "RRID:AB_2921552", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGLIIPMFDTAGYAQKFQGRVAITVDESTSTAYMELSSLRSEDTAVYYCARAEHSSTGTFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLISAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANHLPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.11, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0030", + "inn": "Toripalimab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5002", + "product_url": "https://ichor.bio/toripalimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921553", + "sequences": { + "heavy_chain": "QGQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPIHGLEWIGVIESETGGTAYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCAREGITTVATTYYWYFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.5, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.5% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0031", + "inn": "Camrelizumab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5003", + "product_url": "https://ichor.bio/camrelizumab-biosimilar-research-grade-ich5003", + "rrid": "RRID:AB_2921554", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYMMSWVRQAPGKGLEWVATISGGGANTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLYYFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCLASQTIGTWLTWYQQKPGKAPKLLIYTATSLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVYSIPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0032", + "inn": "Tislelizumab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5004", + "product_url": "https://ichor.bio/tislelizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921555", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLTSYGVHWIRQPPGKGLEWIGVIYADGSTNYNPSLKSRVTISKDTSKNQVSLKLSSVTAADTAVYYCARAYGNYWYIDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSESVSNDVAWYQQKPGQPPKLLINYAFHRFTGVPDRFSGSGYGTDFTLTISSLQAEDVAVYYCHQAYSSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0033", + "inn": "Durvalumab", + "target": "PD-L1", + "target_uniprot": "Q9NZQ7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5005", + "product_url": "https://ichor.bio/durvalumab-biosimilar-research-grade-ich5005", + "rrid": "RRID:AB_2921556", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQRVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0034", + "inn": "Aducanumab", + "target": "Beta Amyloid", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5008", + "product_url": "https://ichor.bio/aducanumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921558", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWFDGTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGARRGPYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.71, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0035", + "inn": "Gantenerumab", + "target": "Beta Amyloid", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5009", + "product_url": "https://ichor.bio/gantenerumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921559", + "sequences": { + "heavy_chain": "QVELVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAINASGTRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGKGNTHKPYGYVRYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVLTQSPATLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGVPARFSGSGSGTDFTLTISSLEPEDFATYYCLQIYNMPITFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.58, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0036", + "inn": "Nesvacumab", + "target": "Angiopoietin 2", + "target_uniprot": "O15123", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5010", + "product_url": "https://ichor.bio/nesvacumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921560", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYDIHWVRQATGKGLEWVSAIGPAGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGLITFGGLIAPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYDNSQTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0037", + "inn": "Belantamab", + "target": "BCMA", + "target_uniprot": "Q02223", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5011", + "product_url": "https://ichor.bio/belantamab-biosimilar-research-grade", + "rrid": "RRID:AB_2921626", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNYWMHWVRQAPGQGLEWMGATYRGHSDTYYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGAIYDGYDVLDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKLLIYYTSNLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYRKLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0038", + "inn": "Sutimlimab", + "target": "C1s", + "target_uniprot": "P09871", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5012", + "product_url": "https://ichor.bio/sutimlimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921561", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVATISSGGSHTYYLDSVKGRFTISRDNSKNTLYLQMNSLRAEDTALYYCARLFTGYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "QIVLTQSPATLSLSPGERATMSCTASSSVSSSYLHWYQQKPGKAPKLWIYSTSNLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCHQYYRLPPITFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0039", + "inn": "Girentuximab", + "target": "Carbonic Anhydrase IX", + "target_uniprot": "Q16790", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5013", + "product_url": "https://ichor.bio/girentuximab-biosimilar-research-grade", + "rrid": "RRID:AB_2921562", + "sequences": { + "heavy_chain": "DVKLVESGGGLVKLGGSLKLSCAASGFTFSNYYMSWVRQTPEKRLELVAAINSDGGITYYLDTVKGRFTISRDNAKNTLYLQMSSLKSEDTALFYCARHRSGYFSMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSQRFMSTTVGDRVSITCKASQNVVSAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADFFCQQYSNYPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.178, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.178% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0040", + "inn": "Utomilumab", + "target": "4-1BB", + "target_uniprot": "Q07011", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5014", + "product_url": "https://ichor.bio/utomilumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921563", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLRISCKGSGYSFSTYWISWVRQMPGKGLEWMGKIYPGDSYTNYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGYGIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "SYELTQPPSVSVSPGQTASITCSGDNIGDQYAHWYQQKPGQSPVLVIYQDKNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCATYTGFGSLAVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.1, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0041", + "inn": "Urelumab", + "target": "4-1BB", + "target_uniprot": "Q07011", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5015", + "product_url": "https://ichor.bio/urelumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921564", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGNYDWYFDLWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPALTFCGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.06, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.06% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0042", + "inn": "Atibuclimab", + "target": "CD14", + "target_uniprot": "P08571", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5016", + "product_url": "https://ichor.bio/atibuclimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921565", + "sequences": { + "heavy_chain": "DVQLQQSGPGLVKPSQSLSLTCTVTGYSITSDSAWNWIRQFPGNRLEWMGYISYSGSTSYNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYYCVRGLRFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVLTQSPASLAVSLGQRATISCRASESVDSYVNSFLHWYQQKPGQPPKLLIYRASNLQSGIPARFSGSGSRTDFTLTINPVEADDVATYYCQQSNEDPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0043", + "inn": "Monalizumab", + "target": "NKG2A", + "target_uniprot": "P26715", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5017", + "product_url": "https://ichor.bio/monalizumab-biosimilar-research-grade-ich5017", + "rrid": "RRID:AB_2921566", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWMNWVRQAPGQGLEWMGRIDPYDSETHYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGYDFDVGTLYWFFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASENIYSYLAWYQQKPGKAPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGTPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.12, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.083, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.083% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0044", + "inn": "Glofitamab", + "target": "CD3 + CD20", + "target_uniprot": "P07766;P11836", + "format": "T-cell engager (TCB) | 2:1 TCB — bivalent tumor + monovalent CD3 | 2 Fabs + 1 CrossFab + heterodimeric Fc (5 chains)", + "isotype": "Humanized IgG1", + "product_sku": "ICH5019", + "product_url": "https://ichor.bio/glofitamab-biosimilar-research-grade", + "rrid": "RRID:AB_2921629", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTVAAPSVFIFPPSDRKLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 194.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0045", + "inn": "Daclizumab", + "target": "IL2RA", + "target_uniprot": "P01589", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5021", + "product_url": "https://ichor.bio/daclizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921568", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTSYRMHWVRQAPGQGLEWIGYINPSTGYTEYNQKFKDKATITADESTNTAYMELSSLRSEDTAVYYCARGGGVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCSASSSISYMHWYQQKPGKAPKLLIYTTSNLASGVPARFSGSGSGTEFTLTISSLQPDDFATYYCHQRSTYPLTFGQGTKVEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.935, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.935% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0046", + "inn": "Varlilumab", + "target": "CD27", + "target_uniprot": "P26842", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5022", + "product_url": "https://ichor.bio/varlilumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921569", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGSGNWGFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGSS", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISRWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNTYPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0047", + "inn": "Mosunetuzumab", + "target": "CD3e + CD20", + "target_uniprot": "P07766", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5026", + "product_url": "https://ichor.bio/mosunetuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921631", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYNMHWVRQAPGKGLEWVGAIYPGNGDTSYNQKFKGRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARVVYYSNSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASSSVSYMHWYQQKPGKAPKPLIYAPSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSFNPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.36, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0048", + "inn": "Odronextamab", + "target": "CD3 + CD20", + "target_uniprot": "P07766;P11836", + "format": "bispecific / multi-chain (3 chains)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5027", + "product_url": "https://ichor.bio/odronextamab-biosimilar-research-grade", + "rrid": "RRID:AB_2921632", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYTMHWVRQAPGKGLEWVSGISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDNSGYGHYYYGMDVWGQGTTVTVASASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNRFTQKSLSLSLGK", + "light_chain": "AEIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQHYINWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 122.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.66, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0049", + "inn": "Isatuximab", + "target": "CD38", + "target_uniprot": "P28907", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5028", + "product_url": "https://ichor.bio/isatuximab-biosimilar-research-grade", + "rrid": "RRID:AB_2921572", + "sequences": { + "heavy_chain": "QVQLVQSGAEVAKPGTSVKLSCKASGYTFTDYWMQWVKQRPGQGLEWIGTIYPGDGDTGYAQKFQGKATLTADKSSKTVYMHLSSLASEDSAVYYCARGDYYGSNSLDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSHLSMSTSLGDPVSITCKASQDVSTVVAWYQQKPGQSPRRLIYSASYRYIGVPDRFTGSGAGTDFTFTISSVQAEDLAVYYCQQHYSPPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0050", + "inn": "Ibalizumab", + "target": "CD4", + "target_uniprot": "P01730", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5029", + "product_url": "https://ichor.bio/ibalizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921573", + "sequences": { + "heavy_chain": "QVQLQQSGPEVVKPGASVKMSCKASGYTFTSYVIHWVRQKPGQGLDWIGYINPYNDGTDYDEKFKGKATLTSDTSTSTAYMELSSLRSEDTAVYYCAREKDNYATGAWFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPDSLAVSLGERVTMNCKSSQSLLYSTNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYYCQQYYSYRTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.81, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0051", + "inn": "Dacetuzumab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5030", + "product_url": "https://ichor.bio/dacetuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921574", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYYIHWVRQAPGKGLEWVARVIPNAGGTSYNQKFKGRFTLSVDNSKNTAYLQMNSLRAEDTAVYYCAREGIYWWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGNTFLHWYQQKPGKAPKLLIYTVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCSQTTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0052", + "inn": "Sotigalimab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5031", + "product_url": "https://ichor.bio/sotigalimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921575", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFSFSSTYVCWVRQAPGKGLEWIACIYTGDGTNYSASWAKGRFTISKDSSKNTVYLQMNSLRAEDTAVYFCARPDITYGFAINFWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVEHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTIKCQASQSISSRLAWYQQKPGKPPKLLIYRASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQCTGYGISWPIGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.46, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0053", + "inn": "Selicrelumab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5032", + "product_url": "https://ichor.bio/selicrelumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921576", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPDSGGTNYAQKFQGRVTMTRDTSISTAYMELNRLRSDDTAVYYCARDQPLGYCTNGVCSYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGIYSWLAWYQQKPGKAPNLLIYTASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANIFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.84, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.435, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.435% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0054", + "inn": "Lemzoparlimab", + "target": "CD47", + "target_uniprot": "Q08722", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5034", + "product_url": "https://ichor.bio/lemzoparlimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921578", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGLTFERAWMNWVRQAPGKGLEWVGRIKRKTDGETTDYAAPVKGRFSISRDDSKNTLYLQMNSLKTEDTAVYYCAGSNRAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLYAGNNRNYLAWYQQKPGQPPKLLINQASTRASGVPDRFSGSGSGTEFTLIISSLQAEDVAIYYCQQYYTPPLAFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0055", + "inn": "Magrolimab", + "target": "CD47", + "target_uniprot": "Q08722", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4", + "product_sku": "ICH5036", + "product_url": "https://ichor.bio/magrolimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921580", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYNMHWVRQAPGQRLEWMGTIYPGNDDTSYNQKFKDRVTITADTSASTAYMELSSLRSEDTAVYYCARGGYRAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSIVYSNGNTYLGWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.066, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.066% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0056", + "inn": "Cusatuzumab", + "target": "CD70", + "target_uniprot": "P32970", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5037", + "product_url": "https://ichor.bio/cusatuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921581", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSVYYMNWVRQAPGKGLEWVSDINNEGGTTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCARDAGYSNHVPIFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QAVVTQEPSLTVSPGGTVTLTCGLKSGSVTSDNFPTWYQQTPGQAPRLLIYNTNTRHSGVPDRFSGSILGNKAALTITGAQADDEAEYFCALFISNPSVEFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0057", + "inn": "Oleclumab", + "target": "CD73", + "target_uniprot": "P21589", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5038", + "product_url": "https://ichor.bio/oleclumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921582", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAYSWVRQAPGKGLEWVSAISGSGGRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLGYGRVDEWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSLSNIGRNPVNWYQQLPGTAPKLLIYLDNLRLSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSHPGWTFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.22, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0058", + "inn": "Polatuzumab", + "target": "CD79b", + "target_uniprot": "P40259", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5039", + "product_url": "https://ichor.bio/polatuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921628", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.63, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0059", + "inn": "Tusamitamab", + "target": "CEACAM5", + "target_uniprot": "P06731", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5040", + "product_url": "https://ichor.bio/tusamitamab-biosimilar-research-grade", + "rrid": "RRID:AB_2921583", + "sequences": { + "heavy_chain": "EVQLQESGPGLVKPGGSLSLSCAASGFVFSSYDMSWVRQTPERGLEWVAYISSGGGITYAPSTVKGRFTVSRDNAKNTLYLQMNSLTSEDTAVYYCAAHYFGSSGPFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPASLSASVGDRVTITCRASENIFSYLAWYQQKPGKSPKLLVYNTRTLAEGVPSRFSGSGSGTDFSLTISSLQPEDFATYYCQHHYGTPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0060", + "inn": "Cibisatamab", + "target": "CEA + CD3", + "target_uniprot": "P06731;P07766", + "format": "T-cell engager (TCB) | 2:1 TCB — bivalent tumor + monovalent CD3 | 2 Fabs + 1 CrossFab + heterodimeric Fc (5 chains)", + "isotype": "Humanized IgG1", + "product_sku": "ICH5041", + "product_url": "https://ichor.bio/cibisatamab-biosimilar-research-grade", + "rrid": "RRID:AB_2921633", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTEFGMNWVRQAPGQGLEWMGWINTKTGEATYVEEFKGRVTFTTDTSTSTAYMELRSLRSDDTAVYYCARWDFAYYVEAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASAAVGTYVAWYQQKPGKAPKLLIYSASYRKRGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCHQYYTYPLFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 194.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.5, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95.928, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 95.928% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0061", + "inn": "Tinurilimab", + "target": "CEACAM6", + "target_uniprot": "P40199", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5042", + "product_url": "https://ichor.bio/tinurilimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921584", + "sequences": { + "heavy_chain": "QVTLRESGPALVKPTQTLTLTCTFSGFSLSTYGIGVGWIRQPPGKALEWLAHIWWNDNKYYSTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARISLPYFDYWGQGTTLTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQLTQSPSFLSASVGDRVTITCKASQNVGTAVAWYQQKPGKAPKLLIYSASNRYTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.18, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0062", + "inn": "Erenumab", + "target": "CGRP receptor", + "target_uniprot": "Q16602", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5043", + "product_url": "https://ichor.bio/erenumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921585", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAVISFDGSIKYSVDSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCARDRLNYYDSSGYYHYKYYGMAVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSTTLGITGLQTGDEADYYCGTWDSRLSAVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.48, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0063", + "inn": "Eptinezumab", + "target": "CALCA, CALCB", + "target_uniprot": "P01258", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 N297A-Kappa", + "product_sku": "ICH5044", + "product_url": "https://ichor.bio/eptinezumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921586", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAVSGIDLSGYYMNWVRQAPGKGLEWVGVIGINGATYYASWAKGRFTISRDNSKTTVYLQMNSLRAEDTAVYFCARGDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDARVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QVLTQSPSSLSASVGDRVTINCQASQSVYHNTYLAWYQQKPGKVPKQLIYDASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLGSYDCTNGDCFVFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0064", + "inn": "Fremanezumab", + "target": "CGRP", + "target_uniprot": "P06881", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5045", + "product_url": "https://ichor.bio/fremanezumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921587", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWISWVRQAPGKGLEWVAEIRSESDASATHYAEAVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCLAYFDYGLAIQNYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCKASKRVTTYVSWYQQKPGQAPRLLIYGASNRYLGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCSQSYNYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0065", + "inn": "Galcanezumab", + "target": "CGRP", + "target_uniprot": "P06881", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P/F234A/L235A/KDel)-Kappa", + "product_sku": "ICH5046", + "product_url": "https://ichor.bio/galcanezumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921588", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFGNYWMQWVRQAPGQGLEWMGAIYEGTGKTVYIQKFADRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSDYVSGFGYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASKDISKYLNWYQQKPGKAPKLLIYYTSGYHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGDALPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.66, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.735, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.735% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0066", + "inn": "Zolbetuximab", + "target": "Claudin 18.2", + "target_uniprot": "P56856", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 K97R-Kappa", + "product_sku": "ICH5047", + "product_url": "https://ichor.bio/zolbetuximab-biosimilar-research-grade", + "rrid": "RRID:AB_2921589", + "sequences": { + "heavy_chain": "QVQLQQPGAELVRPGASVKLSCKASGYTFTSYWINWVKQRPGQGLEWIGNIYPSDSYTNYNQKFKDKATLTVDKSSSTAYMQLSSPTSEDSAVYYCTRSWRGNSFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQNDYSYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0067", + "inn": "Rovalpituzumab", + "target": "DLL3", + "target_uniprot": "Q9NYJ7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5048", + "product_url": "https://ichor.bio/rovalpituzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921590", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGEPTYADDFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARIGDSSPSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVMTQSPATLSVSPGERATLSCKASQSVSNDVVWYQQKPGQAPRLLIYYASNRYTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQDYTSPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0068", + "inn": "Batoclimab", + "target": "FcRn", + "target_uniprot": "P55899", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Lambda2", + "product_sku": "ICH5049", + "product_url": "https://ichor.bio/batoclimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921591", + "sequences": { + "heavy_chain": "QLLLQESGPGLVKPSETLSLTCTVSGGSLSSSFSYWVWIRQPPGKGLEWIGTIYYSGNTYYNPSLKSRLTISVDTSKNHFSLKLSSVTAADTAVYYCARRAGILTGYLDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "SYVLTQSPSVSVAPGQTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSASNSGNTATLTISRVEAGDEADYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.073, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.073% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0069", + "inn": "Nipocalimab", + "target": "FcRn", + "target_uniprot": "P55899", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda3", + "product_sku": "ICH5050", + "product_url": "https://ichor.bio/nipocalimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921592", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYAMGWVRQAPGKGLEWVSSIGASGSQTRYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLAIGDSYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QSALTQPASVSGSPGQSITISCTGTGSDVGSYNLVSWYQQHPGKAPKLMIYGDSERPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYAGSGIYVFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 141.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0070", + "inn": "Rozanolixizumab", + "target": "FcRn", + "target_uniprot": "P55899", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5051", + "product_url": "https://ichor.bio/rozanolixizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921593", + "sequences": { + "heavy_chain": "EVPLVESGGGLVQPGGSLRLSCAVSGFTFSNYGMVWVRQAPGKGLEWVAYIDSDGDNTYYRDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCTTGIVRPFLYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKSSQSLVGASGKTYLYWLFQKPGKAPKRLIYLVSTLDSGIPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQGTHFPHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0071", + "inn": "Aprutumab", + "target": "FGFR2", + "target_uniprot": "P21802", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5052", + "product_url": "https://ichor.bio/aprutumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921594", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGTSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARVRYNWNHGDWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYENYNRPAGVPDRFSGSKSGTSASLAISGLRSEDEADYYCSSWDDSLNYWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0072", + "inn": "Bemarituzumab", + "target": "FGFR2b", + "target_uniprot": "P21802", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5053", + "product_url": "https://ichor.bio/bemarituzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921595", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYIFTTYNVHWVRQAPGQGLEWIGSIYPDNGDTSYNQNFKGRATITADKSTSTAYMELSSLRSEDTAVYYCARGDFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQGVSNDVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQHSTTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0073", + "inn": "Mavrilimumab", + "target": "GM-CSF", + "target_uniprot": "P04141", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - lambda2", + "product_sku": "ICH5054", + "product_url": "https://ichor.bio/mavrilimumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921596", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGYTLTELSIHWVRQAPGKGLEWMGGFDPEENEIVYAQRFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCAIVGSFSPLTLGLWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSGSNIGAPYDVSWYQQLPGTAPKLLIYHNNKRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCATVEAGLSGSVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0074", + "inn": "Codrituzumab", + "target": "GPC3", + "target_uniprot": "P51654", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5055", + "product_url": "https://ichor.bio/codrituzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921597", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGALDPKTGDTAYSQKFKGRVTLTADKSTSTAYMELSSLTSEDTAVYYCTRFYSYTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLVHSNRNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQNTHVPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0075", + "inn": "Margetuximab", + "target": "HER2", + "target_uniprot": "P04626", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5057", + "product_url": "https://ichor.bio/margetuximab-biosimilar-research-grade", + "rrid": "RRID:AB_2921599", + "sequences": { + "heavy_chain": "QVQLQQSGPELVKPGASLKLSCTASGFNIKDTYIHWVKQRPEQGLEWIGRIYPTNGYTRYDPKFQDKATITADTSSNTAYLQVSRLTSEDTAVYYCSRWGGDGFYAMDYWGQGASVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELVGGPSVFLLPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPPEEQYNSTLRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPLVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSHKFMSTSVGDRVSITCKASQDVNTAVAWYQQKPGHSPKLLIYSASFRYTGVPDRFTGSRSGTDFTFTISSVQAEDLAVYYCQQHYTTPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0076", + "inn": "Lebrikizumab", + "target": "IL-13", + "target_uniprot": "P35225", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 S228P-Kappa", + "product_sku": "ICH5058", + "product_url": "https://ichor.bio/lebrikizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921600", + "sequences": { + "heavy_chain": "QVTLRESGPALVKPTQTLTLTCTVSGFSLSAYSVNWIRQPPGKALEWLAMIWGDGKIVYNSALKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCAGDGYYPYAMDNWGQGSLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPDSLSVSLGERATINCRASKSVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQNNEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.923, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.923% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0077", + "inn": "Tralokinumab", + "target": "IL-13", + "target_uniprot": "P35225", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 S228P-Kappa", + "product_sku": "ICH5059", + "product_url": "https://ichor.bio/tralokinumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921601", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGLSWVRQAPGQGLEWMGWISANNGDTNYGQEFQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDSSSSWARWFFDLWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "SYVLTQPPSVSVAPGKTARITCGGNIIGSKLVHWYQQKPGQAPVLVIYDDGDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDTGSDPVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.81, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0078", + "inn": "Brodalumab", + "target": "IL-17RA", + "target_uniprot": "Q96F46;Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5060", + "product_url": "https://ichor.bio/brodalumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921602", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYGISWVRQAPGQGLEWMGWISTYSGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARRQLYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWFQQKPGQAPRPLIYDASTRATGVPARFSGSGSGTDFTLTISSLQSEDFAVYYCQQYDNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.19, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0079", + "inn": "Etokimab", + "target": "IL-33", + "target_uniprot": "O95760", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5061", + "product_url": "https://ichor.bio/etokimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921603", + "sequences": { + "heavy_chain": "QVQLMQSGAEVKKPGASVKVSCKASGYTFTSYWMHWVRQAPGQGLEWMGTIYPRNSNTDYNQKFKARVTMTRDTSTSTVYMELSSLRSEDTAVYYCARPLYYYLTSPPTLFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSFLSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQAKTYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.7, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0080", + "inn": "Dupilumab", + "target": "IL-4R alpha", + "target_uniprot": "P24394", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5062", + "product_url": "https://ichor.bio/dupilumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921604", + "sequences": { + "heavy_chain": "EVQLVESGGGLEQPGGSLRLSCAGSGFTFRDYAMTWVRQAPGKGLEWVSSISGSGGNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRLSITIRPRYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLYSIGYNYLDWYLQKSGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGFYYCMQALQTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.78, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0081", + "inn": "Clazakizumab", + "target": "IL-6", + "target_uniprot": "P05231", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5063", + "product_url": "https://ichor.bio/clazakizumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921605", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFSLSNYYVTWVRQAPGKGLEWVGIIYGSDETAYATSAIGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDDSSDWDAKFNLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "AIQMTQSPSSLSASVGDRVTITCQASQSINNELSWYQQKPGKAPKLLIYRASTLASGVPSRFSGSGSGTDFTLTISSLQPDDFATYYCQQGYSLRNIDNAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0082", + "inn": "Guselkumab", + "target": "IL-23", + "target_uniprot": "Q9NPF7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Lambda3", + "product_sku": "ICH5064", + "product_url": "https://ichor.bio/guselkumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921606", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFSNYWIGWVRQMPGKGLEWMGIIDPSNSYTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARWYYKPFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSSSNIGSGYDVHWYQQLPGTAPKLLIYGNSKRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCASWTDGLSLVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0083", + "inn": "Simtuzumab", + "target": "LOXL2", + "target_uniprot": "Q9Y4K0", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5068", + "product_url": "https://ichor.bio/simtuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921610", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYAFTYYLIEWVRQAPGQGLEWIGVINPGSGGTNYNEKFKGRATITADKSTSTAYMELSSLRSEDTAVYFCARNWMNFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSKSLLHSNGNTYLYWFLQKPGQSPQFLIYRMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQHLEYPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0084", + "inn": "Amatuximab", + "target": "MSLN", + "target_uniprot": "Q13421", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5069", + "product_url": "https://ichor.bio/amatuximab-biosimilar-research-grade", + "rrid": "RRID:AB_2921611", + "sequences": { + "heavy_chain": "QVQLQQSGPELEKPGASVKISCKASGYSFTGYTMNWVKQSHGKSLEWIGLITPYNGASSYNQKFRGKATLTVDKSSSTAYMDLLSLTSEDSAVYFCARGGYDGRGFDYWGSGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIELTQSPAIMSASPGEKVTMTCSASSSVSYMHWYQQKSGTSPKRWIYDTSKLASGVPGRFSGSGSGNSYSLTISSVEAEDDATYYCQQWSKHPLTFGSGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0085", + "inn": "Enfortumab Vedotin", + "target": "Nectin-4", + "target_uniprot": "Q96NY8", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5070V", + "product_url": "https://ichor.bio/enfortumab-vedotin-biosimilar-research-grade-ich5070v", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYNMNWVRQAPGKGLEWVSYISSSSSTIYYADSVKGRFTISRDNAKNSLSLQMNSLRDEDTAVYYCARAYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISGWLAWYQQKPGKAPKFLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0086", + "inn": "Sacituzumab", + "target": "TACSTD2", + "target_uniprot": "P09758", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5076", + "product_url": "https://ichor.bio/sacituzumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921618", + "sequences": { + "heavy_chain": "QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTYTGEPTYTDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCARGGFGSSYWYFDVWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVSITCKASQDVSIAVAWYQQKPGKAPKLLIYSASYRYTGVPDRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGAGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.992, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.992% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0087", + "inn": "Fresolimumab", + "target": "TGF beta 1", + "target_uniprot": "P01137", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 S228P-Kappa", + "product_sku": "ICH5077", + "product_url": "https://ichor.bio/fresolimumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921619", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFSSNVISWVRQAPGQGLEWMGGVIPIVDIANYAQRFKGRVTITADESTSTTYMELSSLRSEDTAVYYCASTLGLVLDAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "ETVLTQSPGTLSLSPGERATLSCRASQSLGSSYLAWYQQKPGQAPRLLIYGASSRAPGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYADSPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.55, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.327, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.327% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0088", + "inn": "Tiragolumab", + "target": "TIGIT", + "target_uniprot": "Q495A1", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5078", + "product_url": "https://ichor.bio/tiragolumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921620", + "sequences": { + "heavy_chain": "EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 148.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.88, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.179, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.179% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0089", + "inn": "Sabatolimab", + "target": "Tim-3", + "target_uniprot": "Q8TDQ0", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 S228P-Kappa", + "product_sku": "ICH5079", + "product_url": "https://ichor.bio/sabatolimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921621", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGDIYPGNGDTSYNQKFKGRVTITADKSTSTVYMELSSLRSEDTAVYYCARVGGAFPMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASESVEYYGTSLMQWYQQKPGKAPKLLIYAASNVESGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQSRKDPSTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0090", + "inn": "Belimumab", + "target": "BAFF", + "target_uniprot": "Q9Y275", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 E239D ,M241L-lambda3 K83R", + "product_sku": "ICH5080", + "product_url": "https://ichor.bio/belimumab-biosimilar-research-grade", + "rrid": "RRID:AB_2921622", + "sequences": { + "heavy_chain": "QVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "SSELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.08, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0091", + "inn": "Onvatilimab", + "target": "VISTA", + "target_uniprot": "Q9H7M9", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5081", + "product_url": "https://ichor.bio/onvatilimab-biosimilar-research-grade", + "rrid": "RRID:AB_2921623", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARSSYGWSYEFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSIDTRLNWYQQKPGKAPKLLIYSASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSAYNPITFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0092", + "inn": "Rosopatamab", + "target": "PMSA", + "target_uniprot": "Q04609", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5083", + "product_url": "https://ichor.bio/rosopatamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075719", + "sequences": { + "heavy_chain": "EVQLVQSGPEVKKPGATVKISCKTSGYTFTEYTIHWVKQAPGKGLEWIGNINPNNGGTTYNQKFEDKATLTVDKSTDTAYMELSSLRSEDTAVYYCAAGWNFDYWGQGTLLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSTSVGDRVTLTCKASQDVGTAVDWYQQKPGPSPKLLIYWASTRHTGIPSRFSGSGSGTDFTLTISSLQPEDFADYYCQQYNSYPLTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.14, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.625, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.625% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0093", + "inn": "Rolinsatamab", + "target": "PRLR", + "target_uniprot": "P16471", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(S239C)-Kappa", + "product_sku": "ICH5084", + "product_url": "https://ichor.bio/rolinsatamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075720", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGYTFTTYWMHWVRQAPGQGLEWIGEIDPSDSYSNYNQKFKDRATLTVDKSTSTAYMELSSLRSEDTAVYYCARNGGLGPAWFSYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCKASQYVGTAVAWYQQKPGKSPKLLIYSASNRYTGVPSRFSDSGSGTDFTLTISSLQPEDFATYFCQQYSSYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.18, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0094", + "inn": "Iratumumab", + "target": "CD30", + "target_uniprot": "P28908", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L/436YDel)-Kappa", + "product_sku": "ICH5085", + "product_url": "https://ichor.bio/iratumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075721", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSAYYWSWIRQPPGKGLEWIGDINHGGGTNYNPSLKSRVTISVDTSKNQFSLKLNSVTAADTAVYYCASLTAYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHTQKSLSLSPGK", + "light_chain": "DIQMTQSPTSLSASVGDRVTITCRASQGISSWLTWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYDSYPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0095", + "inn": "Sofituzumab Vedotin", + "target": "CA125 / MUC16", + "target_uniprot": "Q8WXI7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5086V", + "product_url": "https://ichor.bio/sofituzumab-vedotin-biosimilar-research-grade-ich5086v", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSITNDYAWNWVRQAPGKGLEWVGYISYSGYTTYNPSLKSRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARWTSGLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASDLIHNWLAWYQQKPGKAPKLLIYGATSLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYWTTPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0096", + "inn": "Nadunolimab", + "target": "IL1RAP", + "target_uniprot": "Q9NPH3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(KDel)-Kappa", + "product_sku": "ICH5088", + "product_url": "https://ichor.bio/nadunolimab-biosimilar-research-grade-ich5088", + "rrid": "RRID:AB_3075724", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFTSSWMNWVRQAPGQGLEWMGRIYPGDGNTHYAQKFQGRVTLTADKSTSTAYMELSSLRSEDTAVYYCGEGYLDPMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQGINNYLNWYQQKPGKAPKLLIHYTSGLHAGVPSRFSGSGSGTDYTLTISSLEPEDVATYYCQQYSILPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.35, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.35% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0097", + "inn": "Pivekimab", + "target": "IL-3RA", + "target_uniprot": "P26951", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L/S442C/KDel)-Kappa", + "product_sku": "ICH5089", + "product_url": "https://ichor.bio/pivekimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075725", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFTSSIMHWVRQAPGQGLEWIGYIKPYNDGTKYNEKFKGRATLTSDRSTSTAYMELSSLRSEDTAVYYCAREGGNDYYDTMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLCLSPG", + "light_chain": "EIQMTQSPSSLSASVGDRVTITCRASQDINSYLSWFQQKPGKAPKTLIYRVNRLVDGVPSRFSGSGSGNDYTLTISSLQPEDFATYYCLQYDAFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.04, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0098", + "inn": "Camidanlumab", + "target": "IL2RA", + "target_uniprot": "P01589", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R/E356D/M358L)-Kappa", + "product_sku": "ICH5090", + "product_url": "https://ichor.bio/camidanlumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075726", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSRYIINWVRQAPGQGLEWMGRIIPILGVENYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARKDWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0099", + "inn": "Indusatumab", + "target": "GC-C", + "target_uniprot": "P25092", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5091", + "product_url": "https://ichor.bio/indusatumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075727", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVFGGSFSGYYWSWIRQPPGKGLEWIGEINHRGNTNDNPSLKSRVTISVDTSKNQFALKLSSVTAADTAVYYCARERGYTYGNFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSRNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTIGSLQSEDFAVYYCQQYKTWPRTFGQGTNVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0100", + "inn": "Edrecolomab", + "target": "CD326", + "target_uniprot": "P16422", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "Mouse IgG2a-kappa", + "product_sku": "ICH5092", + "product_url": "https://ichor.bio/edrecolomab-biosimilar-research-grade", + "rrid": "RRID:AB_3075728", + "sequences": { + "heavy_chain": "QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARDGPWFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "NIVMTQSPKSMSMSVGERVTLTCKASENVVTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYHCGQGYSYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0101", + "inn": "Pinatuzumab Vedotin", + "target": "Siglec-2 / CD22", + "target_uniprot": "P20273", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5093V", + "product_url": "https://ichor.bio/pinatuzumab-vedotin-biosimilar-research-grade-ich5093v", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYEFSRSWMNWVRQAPGKGLEWVGRIYPGDGDTNYSGKFKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARDGSSWDWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSIVHSVGNTFLEWYQQKPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCFQGSQFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0102", + "inn": "Upifitamab", + "target": "SLC34A2", + "target_uniprot": "O95436", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R/E356D/M358L)-Kappa", + "product_sku": "ICH5094", + "product_url": "https://ichor.bio/upifitamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075730", + "sequences": { + "heavy_chain": "QVQLVQSGAEVVKPGASVKMSCKASGYTFTGYNIHWVKQAPGQGLEWIGAIYPGNGDTSYKQKFRGRATLTADTSTSTVYMELSSLRSEDSAVYYCARGETARATFAYWGQGTLVTVSSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASQDIGNFLNWYQQKPGKTVKVLIYYTSSLYSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYSKLPLTFGQGTKLELKRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0103", + "inn": "Omburtamab", + "target": "CD276", + "target_uniprot": "Q5ZPR3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "Mouse IgG1-Kappa", + "product_sku": "ICH5095", + "product_url": "https://ichor.bio/omburtamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075731", + "sequences": { + "heavy_chain": "QVQLQQSGAELVKPGASVKLSCKASGYTFTNYDINWVRQRPEQGLEWIGWIFPGDGSTQYNEKFKGKATLTTDTSSSTAYMQLSRLTSEDSAVYFCARQTTATWFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", + "light_chain": "DIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.3, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0104", + "inn": "Daxdilimab", + "target": "ILT-7", + "target_uniprot": "P59901", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Lambda2(K83R）", + "product_sku": "ICH5096", + "product_url": "https://ichor.bio/daxdilimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075732", + "sequences": { + "heavy_chain": "QVQLQQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYNGNTNYAQKLQGRVTMTIDTSTSTAYMELRSLRSDDTAVYYCARNGLWGWDSDAFDIWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTVVFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0105", + "inn": "Mirvetuximab", + "target": "FOLR1", + "target_uniprot": "P15328", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L/KDel)-Kappa", + "product_sku": "ICH5097", + "product_url": "https://ichor.bio/mirvetuximab-biosimilar-research-grade", + "rrid": "RRID:AB_3075733", + "sequences": { + "heavy_chain": "QVQLVQSGAEVVKPGASVKISCKASGYTFTGYFMNWVKQSPGQSLEWIGRIHPYDGDTFYNQKFQGKATLTVDKSSNTAHMELLSLTSEDFAVYYCTRYDGSRAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVLTQSPLSLAVSLGQPAIISCKASQSVSFAGTSLMHWYHQKPGQQPRLLIYRASNLEAGVPDRFSGSGSKTDFTLTISPVEAEDAATYYCQQSREYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.834, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.834% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0106", + "inn": "Ieramilimab", + "target": "LAG3", + "target_uniprot": "P18627", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P/KDel)-Kappa", + "product_sku": "ICH5098", + "product_url": "https://ichor.bio/ieramilimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075734", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGFTLTNYGMNWVRQARGQRLEWIGWINTDTGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPPYYYGTNNAEAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCSSSQDISNYLNWYLQKPGQSPQLLIYYTSTLHLGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYYNLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.26, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0107", + "inn": "Veltuzumab", + "target": "CD20", + "target_uniprot": "P11836", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5099", + "product_url": "https://ichor.bio/veltuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075735", + "sequences": { + "heavy_chain": "QVQLQQSGAEVKKPGSSVKVSCKASGYTFTSYNMHWVKQAPGQGLEWIGAIYPGMGDTSYNQKFKGKATLTADESTNTAYMELSSLRSEDTAFYYCARSTYYGGDWYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTMTCRASSSVSYIHWFQQKPGKAPKPWIYATSNLASGVPVRFSGSGSGTDYTFTISSLQPEDIATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0108", + "inn": "Tovetumab", + "target": "PDGFR alpha", + "target_uniprot": "P16234", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5100", + "product_url": "https://ichor.bio/tovetumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075736", + "sequences": { + "heavy_chain": "QVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMNWIRQAPGKGLEWVSYISSSGSIIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGRIAARGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVSITCRPSQSFSRYINWYQQKPGKAPKLLIHAASSLVGGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQTYSNPPITFGQGTRLEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.3, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0109", + "inn": "Teplizumab", + "target": "CD3E", + "target_uniprot": "P07766", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(L234A/L235A/E356D/M358L)-Kappa", + "product_sku": "ICH5101", + "product_url": "https://ichor.bio/teplizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075737", + "sequences": { + "heavy_chain": "QVQLVQSGGGVVQPGRSLRLSCKASGYTFTRYTMHWVRQAPGKGLEWIGYINPSRGYTNYNQKVKDRFTISRDNSKNTAFLQMDSLRPEDTGVYFCARYYDDHYCLDYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASSSVSYMNWYQQTPGKAPKRWIYDTSKLASGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQWSSNPFTFGQGTKLQITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.56, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.291, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.291% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0110", + "inn": "Tanezumab", + "target": "NGF", + "target_uniprot": "P01138", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2(A330S/P331S)-Kappa", + "product_sku": "ICH5102", + "product_url": "https://ichor.bio/tanezumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075738", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLIGYDLNWIRQPPGKGLEWIGIIWGDGTTDYNSAVKSRVTISKDTSKNQFSLKLSSVTAADTAVYYCARGGYWYATSYYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISNNLNWYQQKPGKAPKLLIYYTSRFHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQEHTLPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0111", + "inn": "Tabalumab", + "target": "BAFF", + "target_uniprot": "Q9Y275", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa(S70N)", + "product_sku": "ICH5103", + "product_url": "https://ichor.bio/tabalumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075739", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGYYDILTGYYYYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSRYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDSTLTISSLEPEDFAVYYCQQRSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSNTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0112", + "inn": "Siltuximab", + "target": "IL-6", + "target_uniprot": "P05231", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5104", + "product_url": "https://ichor.bio/siltuximab-biosimilar-research-grade", + "rrid": "RRID:AB_3075744", + "sequences": { + "heavy_chain": "EVQLVESGGKLLKPGGSLKLSCAASGFTFSSFAMSWFRQSPEKRLEWVAEISSGGSYTYYPDTVTGRFTISRDNAKNTLYLEMSSLRSEDTAMYYCARGLWGYYALDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QIVLIQSPAIMSASPGEKVTMTCSASSSVSYMYWYQQKPGSSPRLLIYDTSNLASGVPVRFSGSGSGTSYSLTISRMEAEDAATYYCQQWSGYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0113", + "inn": "Sifalimumab", + "target": "Interferon Alpha 1", + "target_uniprot": "P0DY56", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Kappa", + "product_sku": "ICH5105", + "product_url": "https://ichor.bio/sifalimumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075745", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYSISWVRQAPGQGLEWMGWISVYNGNTNYAQKFQGRVTMTTDTSTSTAYLELRSLRSDDTAVYYCARDPIAAGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0114", + "inn": "Satralizumab", + "target": "IL-6R", + "target_uniprot": "P08887", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2(C131S/R133K/E137G/C219S/H264Q/R351Q/S374A/Q415E/N430A)-Kappa", + "product_sku": "ICH5106", + "product_url": "https://ichor.bio/satralizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075746", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCAVSGHSISHDHAWSWVRQPPGEGLEWIGFISYSGITNYNPSLQGRVTISRDNSKNTLYLQMNSLRAEDTAVYYCARSLARTTAMDYWGEGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHAHYTQKSLSLSP", + "light_chain": "DIQMTQSPSSLSASVGDSVTITCQASTDISSHLNWYQQKPGKAPELLIYYGSHLLSGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCGQGNRLPYTFGQGTKVEIERTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 5.92, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0115", + "inn": "Sarilumab", + "target": "IL-6R", + "target_uniprot": "P08887", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5107", + "product_url": "https://ichor.bio/sarilumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075747", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASRFTFDDYAMHWVRQAPGKGLEWVSGISWNSGRIGYADSVKGRFTISRDNAENSLFLQMNGLRAEDTALYYCAKGRDSFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYGASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFASYYCQQANSFPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.08, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0116", + "inn": "Romosozumab", + "target": "SOST", + "target_uniprot": "Q9BQB4", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5108", + "product_url": "https://ichor.bio/romosozumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075753", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGEINPNSGGAGYNQKFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARLGYDDIYDDWYFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGDTLPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.62, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.336, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.336% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0117", + "inn": "Robatumumab", + "target": "IGF1R", + "target_uniprot": "P06213;P08069", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5109", + "product_url": "https://ichor.bio/robatumumab-biosimilar-research-grade-ich5109", + "rrid": "RRID:AB_3075754", + "sequences": { + "heavy_chain": "EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSFAMHWVRQAPGKGLEWISVIDTRGATYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGNFYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSVSPGERATLSCRASQSIGSSLHWYQQKPGQAPRLLIKYASQSLSGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCHQSSRLPHTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.52, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0118", + "inn": "Rilotumumab", + "target": "HGF", + "target_uniprot": "P14210", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5110", + "product_url": "https://ichor.bio/rilotumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075755", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGGSISIYYWSWIRQPPGKGLEWIGYVYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLNSVTAADTAVYYCARGGYDFWSGYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVDSNLAWYRQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYINWPPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.87, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0119", + "inn": "Ponezumab", + "target": "APP", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2(A330S/P331S)-Kappa", + "product_sku": "ICH5111", + "product_url": "https://ichor.bio/ponezumab-biosimilar-research-grade-ich5111", + "rrid": "RRID:AB_3075756", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYYTEAYYIHWVRQAPGQGLEWMGRIDPATGNTKYAPRLQDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCASLYSLPVYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSLLYSDAKTYLNWFQQRPGQSPRRLIYQISRLDPGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQGTHYPVLFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.04, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0120", + "inn": "Penpulimab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(L234A/L235A/G237A/E356D/M358L)-Kappa", + "product_sku": "ICH5112", + "product_url": "https://ichor.bio/penpulimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075757", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFAFSSYDMSWVRQAPGKGLDWVATISGGGRYTYYPDSVKGRFTISRDNSKNNLYLQMNSLRAEDTALYYCANRYGEAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSMSASVGDRVTFTCRASQDINTYLSWFQQKPGKSPKTLIYRANRLVSGVPSRFSGSGSGQDYTLTISSLQPEDMATYYCLQYDEFPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0121", + "inn": "Vudalimab", + "target": "PD-1 + CTLA-4", + "target_uniprot": "Q15116;P16410", + "format": "Dual checkpoint inhibitor (NOT a T-cell engager) | Asymmetric — 1 Fab + 1 scFv, both monovalent | Fab (H+L) + scFv-Fc + heterodimeric Fc (3 chains)", + "isotype": "IgG1 (Xencor XmAb Fc)", + "product_sku": "ICH5113", + "product_url": "https://ichor.bio/vudalimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075758", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVSFISYDGNNKYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVLHEALHSHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSASPGERVTLTCRASQSVGNDVAWYQQKPGQAPRLLINYASHRYTGVPDRFTGSGYGTEFTLTISSVQSEDFGVYYCQQDFSSPRTFGGGTKVEIKGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVKPGGSLRLSCVASGFTFSNYWMNWVRQAPGKGLEWVAEIRLYSNNYATHYAESVKGRFTISRDDSKSTLYLQMNNLKTEDTGVYYCTRYYGNYGGYFDVWGRGTLVTVSSEPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 125.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.5, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0122", + "inn": "Farletuzumab", + "target": "FOLR1", + "target_uniprot": "P15328", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5114", + "product_url": "https://ichor.bio/farletuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075759", + "sequences": { + "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCSASGFTFSGYGLSWVRQAPGKGLEWVAMISSGGSYTYYADSVKGRFAISRDNAKNTLFLQMDSLRPEDTGVYFCARHGDDPAWFAYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCSVSSSISSNNLHWYQQKPGKAPKPWIYGTSNLASGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQWSSYPYMYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.276, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.276% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0123", + "inn": "Canakinumab", + "target": "IL1B", + "target_uniprot": "P01584", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5115", + "product_url": "https://ichor.bio/canakinumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075760", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSVYGMNWVRQAPGKGLEWVAIIWYDGDNQYYADSVKGRFTISRDNSKNTLYLQMNGLRAEDTAVYYCARDLRTGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPDFQSVTPKEKVTITCRASQSIGSSLHWYQQKPDQSPKLLIKYASQSFSGVPSRFSGSGSGTDFTLTINSLEAEDAAAYYCHQSSSLPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.746, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.746% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0124", + "inn": "Relatlimab", + "target": "LAG3", + "target_uniprot": "P18627", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5117", + "product_url": "https://ichor.bio/relatlimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075762", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSDYYWNWIRQPPGKGLEWIGEINHRGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYEYNWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSISSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGQGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0125", + "inn": "Ivuxolimab", + "target": "OX40", + "target_uniprot": "P43489", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5119", + "product_url": "https://ichor.bio/ivuxolimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075764", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSYISSSSSTIDYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARESGWYLFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.81, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.297, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.297% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0126", + "inn": "Necitumumab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(F126L/K214R)-Kappa", + "product_sku": "ICH5121", + "product_url": "https://ichor.bio/necitumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075766", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGDYYWSWIRQPPGKGLEWIGYIYYSGSTDYNPSLKSRVTMSVDTSKNQFSLKVNSVTAADTAVYYCARVSIFGVGTFDYWGQGTLVTVSSASTKGPSVLPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHQYGSTPLTFGGGTKAEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0127", + "inn": "Tilvestamab", + "target": "Axl", + "target_uniprot": "P30530", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Kappa", + "product_sku": "ICH5122", + "product_url": "https://ichor.bio/tilvestamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075767", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSFTDFYINWVRQAPGKGLEWVARIFPGGDNTYYNEKFKGRFTLSADTSKSTAYLQMNSLRAEDTAVYYCARRGLYYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGIPYLHWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCSQGTHVPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.5, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0128", + "inn": "Nemolizumab", + "target": "IL-31RA", + "target_uniprot": "Q8NI17", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2(C130S/R132K/E136G/S137G/C218S/H263Q/R350Q/Q414E/G441DEL/K442DEL)-Kappa", + "product_sku": "ICH5123", + "product_url": "https://ichor.bio/nemolizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075768", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYIMNWVRQAPGQGLEWMGLINPYNGGTDYNPQFQDRVTITADKSTSTAYMELSSLRSEDTAVYYCARDGYDDGPYTLETWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSP", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASEDIYSFVAWYQQKPGKAPKLLIYNAQTEAQGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYDSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 5.86, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0129", + "inn": "Enoblituzumab", + "target": "CD276", + "target_uniprot": "Q5ZPR3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R/L235V/ F243L/R292P/Y300L/P396L)-Kappa", + "product_sku": "ICH5124", + "product_url": "https://ichor.bio/enoblituzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075769", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAYISSDSSAIYYADTVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCGRGRENIYYGSRLDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELVGGPSVFLLPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPPEEQYNSTLRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPLVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSFLSASVGDRVTITCKASQNVDTNVAWYQQKPGKAPKALIYSASYRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.025, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.025% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0130", + "inn": "Tilavonemab", + "target": "Tau", + "target_uniprot": "P10636", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5125", + "product_url": "https://ichor.bio/tilavonemab-biosimilar-research-grade-ich5125", + "rrid": "RRID:AB_3075770", + "sequences": { + "heavy_chain": "EVKVVESGGGLVQPGGSMKLSCVVSGFTFSNYWVNWVRQAPGKGLEWVAQIRLKSDNYATHYEESVKGRFTISRDDSKSSVYLQMNNLRAEDSGIYYCTNWEDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVLTQSPDSLAVSLGERATISCRASQSVSTSRYSYIHWYQQKPGQPPKLLIKYASNLESGVPSRFSGSGSGTDFTLNIHPLEPEDFATYYCHHSWEIPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.56, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95.203, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 95.203% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0131", + "inn": "Zagotenemab", + "target": "Tau", + "target_uniprot": "P10636", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P/F234A/L235A/K447Del)-Kappa", + "product_sku": "ICH5126", + "product_url": "https://ichor.bio/zagotenemab-biosimilar-research-grade-ich5126", + "rrid": "RRID:AB_3075771", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYTFSNYWIEWVRQMPGKGLEWMGEILPGSDSIKYEKNFKGQVTISADKSISTAYLQWSSLKASDTAMYYCARRGNYVDDWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRSSQSLVHSNQNTYLHWYQQKPGQAPRLLIYKVDNRFSGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCSQSTLVPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.11, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0132", + "inn": "Teprotumumab", + "target": "IGF1R", + "target_uniprot": "P06213;P08069", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5128", + "product_url": "https://ichor.bio/teprotumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075773", + "sequences": { + "heavy_chain": "QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKWPPWTFGQGTKVESKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.6, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0133", + "inn": "Lucatumumab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(S131A/K214R)-Kappa", + "product_sku": "ICH5129", + "product_url": "https://ichor.bio/lucatumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075774", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYEESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIAAPGPDYWGQGTLVTVSSASTKGPSVFPLAPASKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSLTVTPGEPASISCRSSQSLLYSNGYNYLDWYLQKPGQSPQVLISLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQARQTPFTFGPGTKVDIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.08, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0134", + "inn": "Anifrolumab", + "target": "IFNAR1", + "target_uniprot": "P17181", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R/L351F/L352E/P448S)-Kappa", + "product_sku": "ICH5130", + "product_url": "https://ichor.bio/anifrolumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075775", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYIFTNYWIAWVRQMPGKGLESMGIIYPGDSDIRYSPSFQGQVTISADKSITTAYLQWSSLKASDTAMYYCARHDIEGFDYWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSFFAWYQQKPGQAPRLLIYGASSRATGIPDRLSGSGSGTDFTLTITRLEPEDFAVYYCQQYDSSAITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0135", + "inn": "Uliledlimab", + "target": "NT5E", + "target_uniprot": "P21589", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(N297A)-Kappa", + "product_sku": "ICH5131", + "product_url": "https://ichor.bio/uliledlimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075776", + "sequences": { + "heavy_chain": "EVQLQESGPGLVKPSETLSLTCAVSGYSITSGYYWNWIRQPPGKKLEWMGYINYGGSNGYNPSLKSRITISRDTSKNQFSLKLSSVTAADTAVYYCARDYDAYYEALDDWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLSQSPATLSLSPGERATLSCRASSRVNYMHWYQQKPGQSPRPWISATSNLASGVPARFSGSGSGTSYTLTISSLEPEDFAVYYCQQWSSNPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0136", + "inn": "Tafasitamab", + "target": "CD19", + "target_uniprot": "P15391;P51677", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(S239D/K274Q/Y296F/Y300F/L309V/I332E/A339T/V397M)-Kappa", + "product_sku": "ICH5132", + "product_url": "https://ichor.bio/tafasitamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075777", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKYNEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKALPAPEEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLNSGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.14, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0137", + "inn": "Gevokizumab", + "target": "IL-1B", + "target_uniprot": "P01584", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5133", + "product_url": "https://ichor.bio/gevokizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075778", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDGDESYNPSLKSRLTISKDTSKNQVSLKITSVTAADTAVYFCARNRYDPPWFVDWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVTSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGMEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSTSSLSASVGDRVTITCRASQDISNYLSWYQQKPGKAVKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQQEDFATYFCLQGKMLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.88, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.435, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.435% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0138", + "inn": "Enibarcimab", + "target": "ADM", + "target_uniprot": "P35318", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5134", + "product_url": "https://ichor.bio/enibarcimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075779", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFSRYWIEWVRQAPGQGLEWIGEILPGSGSTNYNQKFQGRVTITADTSTSTAYMELSSLRSEDTAVYYCTEGYEYDGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVLTQSPLSLPVTLGQPASISCRSSQSIVYSNGNTYLEWYLQRPGQSPRLLIYRVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0139", + "inn": "Mupadolimab", + "target": "CD73", + "target_uniprot": "P21589", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(N297Q/E356D/M358L)-Kappa", + "product_sku": "ICH5136", + "product_url": "https://ichor.bio/mupadolimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075780", + "sequences": { + "heavy_chain": "QVQLVQSGAEVEKPGASVKVSCKASGYTFTSYWITWVRQAPGQGLEWMGDIYPGSGNTNYNEKFKTRVTITADKSTSTAYMELSSLRSEDTAVYYCAKEGGLTTEDYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASKNVSTSGYSYMHWYQQKPGQAPRLLIYLASNLESGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCQHSRELPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.14, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0140", + "inn": "Brentuximab Vedotin", + "target": "TNFRSF8 / CD30", + "target_uniprot": "P28908", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5137V", + "product_url": "https://ichor.bio/brentuximab-vedotin-biosimilar-research-grade-ich5137v", + "rrid": "", + "sequences": { + "heavy_chain": "QIQLQQSGPEVVKPGASVKISCKASGYTFTDYYITWVKQKPGQGLEWIGWIYPGSGNTKYNEKFKGKATLTVDTSSSTAFMQLSSLTSEDTAVYFCANYGNYWFAYWGQGTQVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVLTQSPASLAVSLGQRATISCKASQSVDFDGDSYMNWYQQKPGQPPKVLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.66, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0141", + "inn": "Abituzumab", + "target": "CD51", + "target_uniprot": "P06756", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5138", + "product_url": "https://ichor.bio/abituzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075782", + "sequences": { + "heavy_chain": "QVQLQQSGGELAKPGASVKVSCKASGYTFSSFWMHWVRQAPGQGLEWIGYINPRSGYTEYNEIFRDKATMTTDTSTSTAYMELSSLRSEDTAVYYCASFLGRGAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVEPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQAQSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLAWYQQKPGKAPKLLIYYTSKIHSGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQGNTFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0142", + "inn": "Abrilumab", + "target": "ITGA4 + ITGB7", + "target_uniprot": "P13612;P26010", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5139", + "product_url": "https://ichor.bio/abrilumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075783", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGYTLSDLSIHWVRQAPGKGLEWMGGFDPQDGETIYAQKFQGRVTMTEDTSTDTAYMELSSLKSEDTAVYYCATGSSSSWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYGASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFANYYCQQANSFPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.45, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0143", + "inn": "Bapineuzumab", + "target": "APP", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Kappa", + "product_sku": "ICH5140", + "product_url": "https://ichor.bio/bapineuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075784", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNKYTQKSLSLSPG", + "light_chain": "DVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0144", + "inn": "Blosozumab", + "target": "SOST", + "target_uniprot": "Q9BQB4", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P/KDel)-Kappa", + "product_sku": "ICH5141", + "product_url": "https://ichor.bio/blosozumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075785", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGFPIKDTFQHWVRQAPGKGLEWMGWSDPEIGDTEYASKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCATGDTTYKFDFWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVHTAVAWYQQKPGKAPKLLIYWASTRWTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSDYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.18, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0145", + "inn": "Bococizumab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2(A330S/P331S)-Kappa", + "product_sku": "ICH5142", + "product_url": "https://ichor.bio/bococizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075786", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGEISPFGGRTNYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARERPLYASDLWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQRYSLWRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.47, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.526, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.526% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0146", + "inn": "Carlumab", + "target": "CCL2", + "target_uniprot": "P13500", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5143", + "product_url": "https://ichor.bio/carlumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075787", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYGISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDGIYGELDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSDAYLAWYQQKPGQAPRLLIYDASSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCHQYIQLHSFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0147", + "inn": "Cixutumumab", + "target": "IGF1R", + "target_uniprot": "P06213;P08069", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Kappa", + "product_sku": "ICH5144", + "product_url": "https://ichor.bio/cixutumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075788", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARAPLRFLEWSTQDHYYYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "SSELTQDPAVSVALGQTVRITCQGDSLRSYYATWYQQKPGQAPILVIYGENKRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCKSRDGSGQHLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPAECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95.668, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 95.668% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0148", + "inn": "Efalizumab", + "target": "CD11a", + "target_uniprot": "P20701", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Kappa", + "product_sku": "ICH5145", + "product_url": "https://ichor.bio/efalizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075789", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSFTGHWMNWVRQAPGKGLEWVGMIHPSDSETRYNQKFKDRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARGIYFYGTTYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASKTISKYLAWYQQKPGKAPKLLIYSGSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHNEYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0149", + "inn": "Eldelumab", + "target": "CXCL10", + "target_uniprot": "P02778", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5146", + "product_url": "https://ichor.bio/eldelumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075790", + "sequences": { + "heavy_chain": "QMQLVESGGGVVQPGRSLRLSCTASGFTFSNNGMHWVRQAPGKGLEWVAVIWFDGMNKFYVDSVKGRFTISRDNSKNTLYLEMNSLRAEDTAIYYCAREGDGSGIYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPIFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0150", + "inn": "Emapalumab", + "target": "IFN-gamma", + "target_uniprot": "P01579", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5147", + "product_url": "https://ichor.bio/emapalumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075791", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDGSSGWYVPHWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDGSNRWMFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0151", + "inn": "Emibetuzumab", + "target": "MET", + "target_uniprot": "P08581", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P/F234A/L235A/KDel)-Kappa", + "product_sku": "ICH5148", + "product_url": "https://ichor.bio/emibetuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075792", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYYMHWVRQAPGQGLEWMGRVNPNRRGTTYNQKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARANWLDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCSVSSSVSSIYLHWYQQKPGKAPKLLIYSTSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQVYSGYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0152", + "inn": "Enokizumab", + "target": "IL-9", + "target_uniprot": "P15248", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5149", + "product_url": "https://ichor.bio/enokizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075793", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSYYWIEWVRQAPGQGLEWMGEILPGSGTTNPNEKFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARADYYGSDYVKFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQHVITHVTWYQQKPGKAPKLLIYGTSYSYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFYEYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0153", + "inn": "Etrolizumab", + "target": "ITGA4 + ITGB7", + "target_uniprot": "P13612;P26010", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(KDel)-Kappa", + "product_sku": "ICH5150", + "product_url": "https://ichor.bio/etrolizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075794", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFFITNNYWGWVRQAPGKGLEWVGYISYSGSTSYNPSLKSRFTISRDTSKNTFYLQMNSLRAEDTAVYYCARTGSSGYFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASESVDDLLHWYQQKPGKAPKLLIKYASQSISGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGNSLPNTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0154", + "inn": "Evinacumab", + "target": "ANGPTL3", + "target_uniprot": "Q9Y5C1", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5151", + "product_url": "https://ichor.bio/evinacumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075795", + "sequences": { + "heavy_chain": "EVQLVESGGGVIQPGGSLRLSCAASGFTFDDYAMNWVRQGPGKGLEWVSAISGDGGSTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAFFYCAKDLRNTIFGVVIPDAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQSIRSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNSYSYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.78, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0155", + "inn": "Fasinumab", + "target": "NGF", + "target_uniprot": "P01138", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5152", + "product_url": "https://ichor.bio/fasinumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075796", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGFTLTELSIHWVRQAPGKGLEWMGGFDPEDGETIYAQKFQGRVTMTEDTSTDTAYMELTSLRSEDTAVYYCSTIFGVVTNFDNWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASAGDRVTITCRASQAIRNDLGWYQQKPGKAPKRLIYAAFNLQSGVPSRFSGSGSGTEFTLTISSLQPEDLASYYCQQYNRYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0156", + "inn": "Ficlatuzumab", + "target": "HGF", + "target_uniprot": "P14210", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5153", + "product_url": "https://ichor.bio/ficlatuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075797", + "sequences": { + "heavy_chain": "QVQLVQPGAEVKKPGTSVKLSCKASGYTFTTYWMHWVRQAPGQGLEWIGEINPTNGHTNYNQKFQGRATLTVDKSTSTAYMELSSLRSEDTAVYYCARNYVGSIFDYWGQGTLLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAMSLGERVTLNCKASENVVSYVSWYQQKPGQSPKLLIYGASNRESGVPDRFSGSGSATDFTLTISSVQAEDVADYHCGQSYNYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0157", + "inn": "Figitumumab", + "target": "IGF1R", + "target_uniprot": "P06213;P08069", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2(KDel)-Kappa", + "product_sku": "ICH5154", + "product_url": "https://ichor.bio/figitumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075798", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCTASGFTFSSYAMNWVRQAPGKGLEWVSAISGSGGTTFYADSVKGRFTISRDNSRTTLYLQMNSLRAEDTAVYYCAKDLGWSDSYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQFPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASRLHRGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYPCSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.86, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0158", + "inn": "Fletikumab", + "target": "IL-20", + "target_uniprot": "Q9NYY1;Q9UHF5;Q6UXL0", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5155", + "product_url": "https://ichor.bio/fletikumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075799", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKRPGASVKVSCKASGYTFTNDIIHWVRQAPGQRLEWMGWINAGYGNTQYSQNFQDRVSITRDTSASTAYMELISLRSEDTAVYYCAREPLWFGESSPHDYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.63, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0159", + "inn": "Foralumab", + "target": "CD3E", + "target_uniprot": "P07766", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Kappa", + "product_sku": "ICH5156", + "product_url": "https://ichor.bio/foralumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075800", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFKFSGYGMHWVRQAPGKGLEWVAVIWYDGSKKYYVDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQMGYWHFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.506, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.506% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0160", + "inn": "Fulranumab", + "target": "NGF", + "target_uniprot": "P01138", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5157", + "product_url": "https://ichor.bio/fulranumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075801", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTLRSYSMNWVRQAPGKGLEWVSYISRSSHTIFYADSVKGRFTISRDNAKNSLYLQMDSLRDEDTAMYYCARVYSSGWHVSDYFDYWGQGILVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0161", + "inn": "Zilovertamab", + "target": "ROR1", + "target_uniprot": "Q01973", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5158", + "product_url": "https://ichor.bio/zilovertamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075802", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGYAFTAYNIHWVRQAPGQGLEWMGSFDPYDGGSSYNQKFKDRLTISKDTSKNQVVLTMTNMDPVDTATYYCARGWYYFDYWGHGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQTPLSLPVTPGEPASISCRASKSISKYLAWYQQKPGQAPRLLIYSGSTLQSGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCQQHDESPYTFGEGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.16, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.258, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.258% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0162", + "inn": "Vibostolimab", + "target": "TIGIT", + "target_uniprot": "Q495A1", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5159", + "product_url": "https://ichor.bio/vibostolimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075803", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGYTFSSYVMHWVRQAPGQGLEWIGYIDPYNDGAKYAQKFQGRVTLTSDKSTSTAYMELSSLRSEDTAVYYCARGGPYGWYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASEHIYSYLSWYQQKPGKVPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQHHFGSPLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0163", + "inn": "Burosumab", + "target": "FGF23", + "target_uniprot": "Q9GZV9", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5160", + "product_url": "https://ichor.bio/burosumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075804", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHYMHWVRQAPGQGLEWMGIINPISGSTSNAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARDIVDAFDFWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALVWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNDYFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0164", + "inn": "Cemiplimab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5161", + "product_url": "https://ichor.bio/cemiplimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075805", + "sequences": { + "heavy_chain": "EVQLLESGGVLVQPGGSLRLSCAASGFTFSNFGMTWVRQAPGKGLEWVSGISGGGRDTYFADSVKGRFTISRDNSKNTLYLQMNSLKGEDTAVYYCVKWGNIYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDSITITCRASLSINTFLNWYQQKPGKAPNLLIYAASSLHGGVPSRFSGSGSGTDFTLTIRTLQPEDFATYYCQQSSNTPFTFGPGTVVDFRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.09, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.061, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.061% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0165", + "inn": "Glembatumumab", + "target": "GPNMB", + "target_uniprot": "Q14956", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5163", + "product_url": "https://ichor.bio/glembatumumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075806", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSFNYYWSWIRHHPGKGLEWIGYIYYSGSTYSNPSLKSRVTISVDTSKNQFSLTLSSVTAADTAVYYCARGYNWNYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVDNNLVWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.87, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0166", + "inn": "Naxitamab", + "target": "Ganglioside GD2", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R/E356D/M358L)-Kappa", + "product_sku": "ICH5164", + "product_url": "https://ichor.bio/naxitamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075807", + "sequences": { + "heavy_chain": "QVQLVESGPGVVQPGRSLRISCAVSGFSVTNYGVHWVRQPPGKGLEWLGVIWAGGITNYNSAFMSRLTISKDNSKNTVYLQMNSLRAEDTAMYYCASRGGHYGYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQTPATLSVSAGERVTITCKASQSVSNDVTWYQQKPGQAPRLLIYSASNRYSGVPARFSGSGYGTEFTFTISSVQSEDFAVYFCQQDYSSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 96.588, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 96.588% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0167", + "inn": "Ixekizumab", + "target": "IL-17A", + "target_uniprot": "Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5165", + "product_url": "https://ichor.bio/ixekizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075808", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYSFTDYHIHWVRQAPGQGLEWMGVINPMYGTTDYNQRFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDYFTGTGVYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSRSLVHSRGNTYLHWYLQKPGQSPQLLIYKVSNRFIGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHLPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.69, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.167, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.167% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0168", + "inn": "Lenzilumab", + "target": "CSF2", + "target_uniprot": "P04141", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5166", + "product_url": "https://ichor.bio/lenzilumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075809", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYSFTNYYIHWVRQAPGQRLEWMGWINAGNGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCVRRQRFPYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSVSPGERATLSCRASQSVGTNVAWYQQKPGQAPRVLIYSTSSRATGITDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFNKSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.77, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0169", + "inn": "Lirilumab", + "target": "KIR2DL1", + "target_uniprot": "P43626;Q14953;Q14954", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5167", + "product_url": "https://ichor.bio/lirilumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075810", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSFYAISWVRQAPGQGLEWMGGFIPIFGAANYAQKFQGRVTITADESTSTAYMELSSLRSDDTAVYYCARIPSGSYYYDYDMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPVTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.78, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0170", + "inn": "Inebilizumab", + "target": "CD19", + "target_uniprot": "P15391;P51677", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5168", + "product_url": "https://ichor.bio/inebilizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075811", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSWMNWVRQAPGKGLEWVGRIYPGDGDTNYNVKFKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARSGFITTVRDFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPDFQSVTPKEKVTITCRASESVDTFGISFMNWFQQKPDQSPKLLIHEASNQGSGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQSKEVPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.13, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.359, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.359% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0171", + "inn": "Motavizumab", + "target": "RSV", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5169", + "product_url": "https://ichor.bio/motavizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075812", + "sequences": { + "heavy_chain": "QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0172", + "inn": "Olokizumab", + "target": "IL-6", + "target_uniprot": "P05231", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P)-Kappa", + "product_sku": "ICH5170", + "product_url": "https://ichor.bio/olokizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075813", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNFNDYFMNWVRQAPGKGLEWVAQMRNKNYQYGTYYAESLEGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARESYYGFTSYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDIGISLSWYQQKPGKAPKLLIYNANNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQHNSAPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0173", + "inn": "Otelixizumab", + "target": "CD3E", + "target_uniprot": "P07766", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(N297A/E356D/M358L)-Lambda2(K83R)", + "product_sku": "ICH5171", + "product_url": "https://ichor.bio/otelixizumab-biosimilar-research-grade-ich5171", + "rrid": "RRID:AB_3075814", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSFPMAWVRQAPGKGLEWVSTISTSGGRTYYRDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKFRQYSGGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQPNSVSTSLGSTVKLSCTLSSGNIENNYVHWYQLYEGRSPTTMIYDDDKRPDGVPDRFSGSIDRSSNSAFLTIHNVAIEDEAIYFCHSYVSSFNVFGGGTKLTVLRQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0174", + "inn": "Ozanezumab", + "target": "NOGO-A", + "target_uniprot": "Q9NQC3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(L235A/G237A/E356D/M358L)-Kappa", + "product_sku": "ICH5173", + "product_url": "https://ichor.bio/ozanezumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075816", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWMHWVRQAPGQGLEWIGNINPSNGGTNYNEKFKSKATMTRDTSTSTAYMELSSLRSEDTAVYYCELMQGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSNPVTLGQPVSISCRSSKSLLYKDGKTYLNWFLQRPGQSPQLLIYLMSTRASGVPDRFSGGGSGTDFTLKISRVEAEDVGVYYCQQLVEYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0175", + "inn": "Panobacumab", + "target": "Pseudomonas aeruginosa serotype IATS O11", + "target_uniprot": null, + "format": "IgM (pentamer; 5x[2H+2L]+J-chain, theoretical)", + "isotype": "IgM-Kappa", + "product_sku": "ICH5174", + "product_url": "https://ichor.bio/panobacumab-biosimilar-research-grade-ich5174", + "rrid": "RRID:AB_3075817", + "sequences": { + "heavy_chain": "EEQVVESGGGFVQPGGSLRLSCAASGFTFSPYWMHWVRQAPGKGLVWVSRINSDGSTYYADSVKGRFTISRDNARNTLYLQMNSLRAEDTAVYYCARDRYYGPEMWGQGTMVTVSSGSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITFSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLSQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNRDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 864.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0176", + "inn": "Parsatuzumab", + "target": "EGFL7", + "target_uniprot": "Q9UHF1", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1-Kappa", + "product_sku": "ICH5175", + "product_url": "https://ichor.bio/parsatuzumab-biosimilar-research-grade-ich5175", + "rrid": "RRID:AB_3075818", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFIDYYMNWVRQAPGKGLEWVGDINLDNSGTHYNQKFKGRFTISRDKSKNTAYLQMNSLRAEDTAVYYCAREGVYHDYDDYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSQSLVHINAITYLHWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCGQSTHVPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0177", + "inn": "Fezakinumab", + "target": "IL-22", + "target_uniprot": "Q9GZX6;Q8N6P7;Q969J5", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(KDel)- Lambda 2(K83R)", + "product_sku": "ICH5176", + "product_url": "https://ichor.bio/fezakinumab-biosimilar-research-grade-ich5176", + "rrid": "RRID:AB_3075819", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMHWVRQAPGQGLEWVGWINPYTGSAFYAQKFRGRVTMTRDTSISTAYMELSRLRSDDTAVYYCAREPEKFDSDDSDVWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QAVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYGVHWYQQLPGTAPKLLIYGDSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDNSLSGYVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.806, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.806% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0178", + "inn": "Emicizumab", + "target": "Factor IX + Factor X", + "target_uniprot": "P00740;P00742", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "IgG4 mutation-kappa", + "product_sku": "ICH5178", + "product_url": "https://ichor.bio/emicizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075821", + "sequences": { + "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFSYYDIQWVRQAPGKGLEWVSSISPSGQSTYYRREVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRTGREYGGGWYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQKEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNRYTQKSLSLSP", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASRNIERQLAWYQQKPGQAPELLIYQASRKESGVPDRFSGSRYGTDFTLTISSLQPEDIATYYCQQYSDPPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.46, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.318, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.318% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0179", + "inn": "Ozuriftamab", + "target": "ROR2", + "target_uniprot": "Q01974", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L/KDel)-Kappa", + "product_sku": "ICH5179", + "product_url": "https://ichor.bio/ozuriftamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075822", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLRISCKGSGYTFTEYTMHWVRQAPGQGLEWMGGINTNNGGTGYNQKFKGRVTISADKSISTAYLQWSSLKASDTAMYYCAHGSLYSYGNSYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "AIQLTQSPSSLSASVGDRVTITCSATSSVSYMHWYLQKPGQSPQLLIYGTSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQRSSYPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0180", + "inn": "Bamlanivimab", + "target": "SARS-CoV-2", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(K214R)-Kappa", + "product_sku": "ICH5180", + "product_url": "https://ichor.bio/bamlanivimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075823", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNYAISWVRQAPGQGLEWMGRIIPILGIANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGYYEARHYYYYYAMDVWGQGTAVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSYLSWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTITSLQPEDFATYYCQQSYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.64, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0181", + "inn": "Ponsegromab", + "target": "GDF15", + "target_uniprot": "Q99988", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(L234A/L235A/G237A/KDel)-Kappa", + "product_sku": "ICH5182", + "product_url": "https://ichor.bio/ponsegromab-biosimilar-research-grade", + "rrid": "RRID:AB_3075825", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFSSYNIDWVRQAPGQGLEWMGGINPIFGTAFYNQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCAREAITTVGAMDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRTSQSVHNYLAWYQQKPGQAPRLLIYDASTRADGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQFWSWPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.14, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0182", + "inn": "Lusvertikimab", + "target": "IL-7RA", + "target_uniprot": "P16871", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4(S228P/L445P)-Kappa", + "product_sku": "ICH5183", + "product_url": "https://ichor.bio/lusvertikimab-biosimilar-research-grade", + "rrid": "RRID:AB_3075826", + "sequences": { + "heavy_chain": "QVQLVESGGGLVKPGGSLRLSCAVSGFTLSDYYMAWIRQAPGKGLEWVSTISASGLRTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARPLSAHYGFNYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSEDIYQGLAWYQQKPGKAPKLLLYSANTLHIGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYYDYPLAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0183", + "inn": "Tremelimumab", + "target": "CTLA-4", + "target_uniprot": "P16410", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 kappa", + "product_sku": "ICH5184", + "product_url": "https://ichor.bio/tremelimumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075827", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDPRGATLYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSINSYLDWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.04, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0184", + "inn": "Mogamulizumab", + "target": "CCR4", + "target_uniprot": "Q9UK39;Q9ULM6;P51679", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1κ", + "product_sku": "ICH5186", + "product_url": "https://ichor.bio/mogamulizumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075829", + "sequences": { + "heavy_chain": "EVQLVESGGDLVQPGRSLRLSCAASGFIFSNYGMSWVRQAPGKGLEWVATISSASTYSYYPDSVKGRFTISRDNAKNSLYLQMNSLRVEDTALYYCGRHSDGNFAFGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVLMTQSPLSLPVTPGEPASISCRSSRNIVHINGDTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSLLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0185", + "inn": "Oxelumab", + "target": "CD37", + "target_uniprot": "P11049", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1CH2+CH3(E356D/M358L)-Kappa", + "product_sku": "ICH5187", + "product_url": "https://ichor.bio/oxelumab-biosimilar-research-grade-ich5187", + "rrid": "RRID:AB_3075832", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFNSYAMSWVRQAPGKGLEWVSIISGSGGFTYYADSVKGRFTISRDNSRTTLYLQMNSLRAEDTAVYYCAKDRLVAPGTFDYWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0186", + "inn": "Briakinumab", + "target": "CD30", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5188", + "product_url": "https://ichor.bio/briakinumab-biosimilar-research-grade-1", + "rrid": "RRID:AB_3075835", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIRYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCKTHGSHDNWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSVSGAPGQRVTISCSGSRSNIGSNTVKWYQQLPGTAPKLLIYYNDQRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDRYTHPALLFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0187", + "inn": "Elotuzumab", + "target": "SLAMF7", + "target_uniprot": "Q9NQ25", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5202", + "product_url": "https://ichor.bio/elotuzumab-biosimilar-research-grade-ich5202", + "rrid": "RRID:AB_3075852", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFDFSRYWMSWVRQAPGKGLEWIGEINPDSSTINYAPSLKDKFIISRDNAKNSLYLQMNSLRAEDTAVYYCARPDGNYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVGIAVAWYQQKPGKVPKLLIYWASTRHTGVPDRFSGSGSGTDFTLTISSLQPEDVATYYCQQYSSYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.115, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.115% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0188", + "inn": "Patritumab", + "target": "HER3", + "target_uniprot": "P21860", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5206", + "product_url": "https://ichor.bio/patritumab-biosimilar-research-grade-ich5206", + "rrid": "RRID:AB_3075856", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWTWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIEMTQSPDSLAVSLGERATINCRSSQSVLYSSSNRNYLAWYQQNPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0189", + "inn": "Patritumab Deruxtecan", + "target": "ERBB3 / HER3", + "target_uniprot": "P21860", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5206D", + "product_url": "https://ichor.bio/patritumab-deruxtecan-biosimilar-research-grade-ich5206d", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWTWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIEMTQSPDSLAVSLGERATINCRSSQSVLYSSSNRNYLAWYQQNPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0190", + "inn": "Talquetamab", + "target": "CD3 + GPRC5D", + "target_uniprot": "P07766;Q9NZD1", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "N/A", + "product_sku": "ICH5207", + "product_url": "https://ichor.bio/talquetamab-biosimilar-research-grade-ich5207", + "rrid": "RRID:AB_3075857", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARHGNFGNSYVSWFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "QTVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.47, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0191", + "inn": "Teclistamab", + "target": "CD3 + BCMA", + "target_uniprot": "P07766;Q02223", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "IgG4 - lambda", + "product_sku": "ICH5209", + "product_url": "https://ichor.bio/teclistamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075859", + "sequences": { + "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSISSGSYFWGWIRQPPGKGLEWIGSIYYSGITYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARHDGAVAGLFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQPPGQAPVVVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEAVYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKGDSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.14, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.14% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0192", + "inn": "Risankizumab", + "target": "IL-23α", + "target_uniprot": "Q9NPF7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5210", + "product_url": "https://ichor.bio/risankizumab-biosimilar-research-grade-ich5210", + "rrid": "RRID:AB_3075860", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDQTIHWMRQAPGQGLEWIGYIYPRDDSPKYNENFKGKVTITADKSTSTAYMELSSLRSEDTAVYYCAIPDRSGYAWFIYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASRDVAIAVAWYQQKPGKVPKLLIYWASTRHTGVPSRFSGSGSRTDFTLTISSLQPEDVADYFCHQYSSYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0193", + "inn": "Onartuzumab", + "target": "MET", + "target_uniprot": "P08581", + "format": "Fab fragment (1 H-fragment + 1 L)", + "isotype": "(Fab - G1 - kappa) - (Fc - G1)", + "product_sku": "ICH5212", + "product_url": "https://ichor.bio/onartuzumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075862", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYWLHWVRQAPGKGLEWVGMIDPSNSDTRFNPNFKDRFTISADTSKNTAYLQMNSLRAEDTAVYYCATYRSYVTPLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKSSQSLLYTSSQKNYLAWYQQKPGKAPKLLIYWASTRESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYAYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 73.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0194", + "inn": "Tezepelumab", + "target": "TSLP", + "target_uniprot": "Q969D9", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5213", + "product_url": "https://ichor.bio/tezepelumab-biosimilar-research-grade", + "rrid": "RRID:AB_3075863", + "sequences": { + "heavy_chain": "QMQLVESGGGVVQPGRSLRLSCAASGFTFRTYGMHWVRQAPGKGLEWVAVIWYDGSNKHYADSVKGRFTITRDNSKNTLNLQMNSLRAEDTAVYYCARAPQWELVHEAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "SYVLTQPPSVSVAPGQTARITCGGNNLGSKSVHWYQQKPGQAPVLVVYDDSDRPSWIPERFSGSNSGNTATLTISRGEAGDEADYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.17, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 97.029, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 97.029% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0195", + "inn": "Prezalumab", + "target": "B7H2", + "target_uniprot": "O75144", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5214", + "product_url": "https://ichor.bio/prezalumab-biosimilar-research-grade-ich5214", + "rrid": "RRID:AB_3075864", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVAYIKQDGNEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGILWFGDLPTFWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISNWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYDSYPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.38, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0196", + "inn": "Ganitumab", + "target": "IGF1R", + "target_uniprot": "P06213;P08069", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5216", + "product_url": "https://ichor.bio/ganitumab-biosimilar-research-grade-ich5216", + "rrid": "RRID:AB_3075866", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARWTGRTDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0197", + "inn": "Datopotamab Deruxtecan", + "target": "TROP2", + "target_uniprot": "P09758", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5217D", + "product_url": "https://ichor.bio/datopotamab-deruxtecan-biosimilar-research-grade-ich5217d", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0198", + "inn": "Lecanemab", + "target": "Amyloid Beta", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5219", + "product_url": "https://ichor.bio/lecanemab-biosimilar-research-grade", + "rrid": "RRID:AB_3075869", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCSASGFTFSSFGMHWVRQAPGKGLEWVAYISSGSSTIYYGDTVKGRFTISRDNAKNSLFLQMSSLRAEDTAVYYCAREGGYYYGRSYYTMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTPGAPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLRISRVEAEDVGIYYCFQGSHVPPTFGPGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0199", + "inn": "Amivantamab", + "target": "EGFR + MET", + "target_uniprot": "P00533;P08581", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5222", + "product_url": "https://ichor.bio/amivantamab-biosimilar-research-grade", + "rrid": "RRID:AB_3075872", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCETSGYTFTSYGISWVRQAPGHGLEWMGWISAYNGYTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDLRGTNYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISNWLAWFQHKPGKAPKLLIYAASSLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0200", + "inn": "Tisotumab", + "target": "CD142", + "target_uniprot": "P13726", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5293", + "product_url": "https://ichor.bio/tisotumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVSSISGSGDYTYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSPWGYYLDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPPSLSASAGDRVTITCRASQGISSRLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0201", + "inn": "Tisotumab Vedotin", + "target": "TF / Factor III / Tissue Factor / CD142", + "target_uniprot": "P13726", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5293V", + "product_url": "https://ichor.bio/tisotumab-vedotin-biosimilar-research-grade-ich5293v", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVSSISGSGDYTYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSPWGYYLDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPPSLSASAGDRVTITCRASQGISSRLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0202", + "inn": "Depatuxizumab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5294", + "product_url": "https://ichor.bio/depatuxizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGYSISSDFAWNWIRQPPGKGLEWMGYISYSGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTAGRGFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSMSVSVGDRVTITCHSSQDINSNIGWLQQKPGKSFKGLIYHGTNLDDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCVQYAQFPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0203", + "inn": "Pozelimab", + "target": "C5", + "target_uniprot": "P01031", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5295", + "product_url": "https://ichor.bio/pozelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGDSVSSSYWTWIRQPPGKGLEWIGYIYYSGSSNYNPSLKSRATISVDTSKNQFSLKLSSVTAADTAVYYCAREGNVDTTMIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "AIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKLLIYAASSLQSGVPSRFAGRGSGTDFTLTISSLQPEDFATYYCLQDFNYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.38, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0204", + "inn": "Retifanlimab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5296", + "product_url": "https://ichor.bio/retifanlimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYSFTSYWMNWVRQAPGQGLEWIGVIHPSDSETWLDQKFKDRVTITVDKSTSTAYMELSSLRSEDTAVYYCAREHYGTSPFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASESVDNYGMSFMNWFQQKPGQPPKLLIHAASNQGSGVPSRFSGSGSGTDFTLTISSLEPEDFAVYFCQQSKEVPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.35, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0205", + "inn": "Ublituximab", + "target": "CD20", + "target_uniprot": "P11836", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5297", + "product_url": "https://ichor.bio/ublituximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QAYLQQSGAELVRPGASVKMSCKASGYTFTSYNMHWVKQTPRQGLEWIGGIYPGNGDTSYNQKFKGKATLTVGKSSSTAYMQLSSLTSEDSAVYFCARYDYNYAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPARFSGSGSGTSYSFTISRVEAEDAATYYCQQWTFNPPTFGGGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.57, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0206", + "inn": "Loncastuximab", + "target": "CD19", + "target_uniprot": "P15391;P51677", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5298", + "product_url": "https://ichor.bio/loncastuximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQPGAEVVKPGASVKLSCKTSGYTFTSNWMHWVKQAPGQGLEWIGEIDPSDSYTNYNQNFQGKAKLTVDKSTSTAYMEVSSLRSDDTAVYYCARGSNPYYYAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPAIMSASPGERVTMTCSASSGVNYMHWYQQKPGTSPRRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEPEDAATYYCHQRGSYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.204, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.204% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0207", + "inn": "Crizanlizumab", + "target": "SELP", + "target_uniprot": "P16109", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5300", + "product_url": "https://ichor.bio/crizanlizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYDINWVRQAPGKGLEWMGWIYPGDGSIKYNEKFKGRVTMTVDKSTDTAYMELSSLRSEDTAVYYCARRGEYGNYEGAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVTSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGMEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCAVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQSVDYDGHSYMNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSDENPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.46, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.767, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.767% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0208", + "inn": "Lanadelumab", + "target": "KLKB1", + "target_uniprot": "P03952", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5302", + "product_url": "https://ichor.bio/lanadelumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVPRRDEFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0209", + "inn": "Tildrakizumab", + "target": "IL-23A", + "target_uniprot": "Q9NPF7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5303", + "product_url": "https://ichor.bio/tildrakizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFITYWMTWVRQAPGQGLEWMGQIFPASGSADYNEKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGGGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSENIYSYLAWYQQKPGKAPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGIPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0210", + "inn": "Bezlotoxumab", + "target": "Toxin B", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5304", + "product_url": "https://ichor.bio/bezlotoxumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKSGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIFYPGDSSTRYSPSFQGQVTISADKSVNTAYLQWSSLKASDTAMYYCARRRNWGNAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSTWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0211", + "inn": "Olaratumab", + "target": "CD140a", + "target_uniprot": "P16234", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5305", + "product_url": "https://ichor.bio/olaratumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSINSSSYYWGWLRQSPGKGLEWIGSFFYTGSTYYNPSLRSRLTISVDTSKNQFSLMLSSVTAADTAVYYCARQSTYYYGSGNYYGWFDRWDQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPAFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0212", + "inn": "Obiltoxaximab", + "target": "Anthrax PA", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5306", + "product_url": "https://ichor.bio/obiltoxaximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQSGPELKKPGASVKVSCKDSGYAFSSSWMNWVRQAPGQGLEWIGRIYPGDGDTNYNGKFQGRVTITADKSSSTAYMELSSLRSEDTAVYFCARSGLLRYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAVKLLIYYTSRLLPGVPSRFSGSGSGTDYSLTISSQEQEDIGTYFCQQGNTLPWTFGQGTKVEIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0213", + "inn": "Idarucizumab", + "target": "Pradaxa", + "target_uniprot": null, + "format": "Fab fragment (1 H-fragment + 1 L)", + "isotype": "Fab - G1 - kappa", + "product_sku": "ICH5307", + "product_url": "https://ichor.bio/idarucizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLTSYIVDWIRQPPGKGLEWIGVIWAGGSTGYNSALRSRVSITKDTSKNQFSLKLSSVTAADTAVYYCASAAYYSYYNYDGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSLLYTDGKTYLYWFLQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQSTHFPHTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 47.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.56, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0214", + "inn": "Dinutuximab", + "target": "Ganglioside GD2", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5308", + "product_url": "https://ichor.bio/dinutuximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLQSGPELEKPGASVMISCKASGSSFTGYNMNWVRQNIGKSLEWIGAIDPYYGGTSYNQKFKGRATLTVDKSSSTAYMHLKSLTSEDSAVYYCVSGMEYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRSSQSLVHRNGNTYLHWYLQKPGQSPKLLIHKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0215", + "inn": "Dostarlimab", + "target": "PD-1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5311", + "product_url": "https://ichor.bio/dostarlimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISGGGSYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASPYYAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQLTQSPSFLSAYVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTLHTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQHYSSYPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.84, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.065, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.065% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0216", + "inn": "Benralizumab", + "target": "IL-5RA", + "target_uniprot": "Q01344", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5313", + "product_url": "https://ichor.bio/benralizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYVIHWVRQRPGQGLAWMGYINPYNDGTKYNERFKGKVTITSDRSTSTVYMELSSLRSEDTAVYLCGREGIRYYGLLGDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCGTSEDIINYLNWYQQKPGKAPKLLIYHTSRLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYTLPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.591, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.591% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0217", + "inn": "Telisotuzumab", + "target": "MET", + "target_uniprot": "P08581", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5315", + "product_url": "https://ichor.bio/telisotuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFTAYTMHWVRQAPGQGLEWMGWIKPNNGLANYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSEITTEFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDCHCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSESVDSYANSFLHWYQQKPGQPPKLLIYRASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEDPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 95, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, >95% spec)" + } + ] + }, + { + "entry_id": "ICB-BSR-0218", + "inn": "Telisotuzumab Vedotin", + "target": "HGFR / c-Met", + "target_uniprot": "P08581", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5315V", + "product_url": "https://ichor.bio/telisotuzumab-vedotin-biosimilar-research-grade-ich5315v", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFTAYTMHWVRQAPGQGLEWMGWIKPNNGLANYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSEITTEFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDCHCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSESVDSYANSFLHWYQQKPGQPPKLLIYRASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEDPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0219", + "inn": "Ravulizumab", + "target": "Complement C5", + "target_uniprot": "P01031", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-G4 - kappa", + "product_sku": "ICH5317", + "product_url": "https://ichor.bio/ravulizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGHIFSNYWIQWVRQAPGQGLEWMGEILPGSGHTEYTENFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYFFGSSPNWYFDVWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVLHEALHSHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCGASENIYGALNWYQQKPGKAPKLLIYGATNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLNTPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 99.763, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 99.763% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0220", + "inn": "Epcoritamab", + "target": "CD3E + CD20", + "target_uniprot": "P07766;P11836", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "Ig(G1 - kappa_G1 - lambda2)", + "product_sku": "ICH5319", + "product_url": "https://ichor.bio/epcoritamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPDRSLRLSCAASGFTFHDYAMHWVRQAPGKGLEWVSTISWNSGTIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.28, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0221", + "inn": "Faricimab", + "target": "ANGPT2 + VEGFA", + "target_uniprot": "O15123;P15692", + "format": "Dual angiogenesis inhibitor (NOT a T-cell engager) | 1:1 bispecific IgG — 1 Fab per target, both monovalent | 2 Fabs (1 normal + 1 CrossMab) + heterodimeric Fc (4 chains)", + "isotype": "Humanized IgG1", + "product_sku": "ICH5320", + "product_url": "https://ichor.bio/faricimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMASRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLAQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNAYTQKSLSLSPGK", + "light_chain": "SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHWVFGGGTKLTVLSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.8, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0222", + "inn": "Abagovomab", + "target": "CA 125", + "target_uniprot": "Q8WXI7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5321", + "product_url": "https://ichor.bio/abagovomab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVKLQESGAELARPGASVKLSCKASGYTFTNYWMQWVKQRPGQGLDWIGAIYPGDGNTRYTHKFKGKATLTADKSSSTAYMQLSSLASEDSGVYYCARGEGNYAWFAYWGQGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", + "light_chain": "DIELTQSPASLSASVGETVTITCQASENIYSYLAWHQQKQGKSPQLLVYNAKTLAGGVSSRFSGSGSGTHFSLKIKSLQPEDFGIYYCQHHYGILPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.19, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0223", + "inn": "Abelacimab", + "target": "F11", + "target_uniprot": "P03951", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5322", + "product_url": "https://ichor.bio/abelacimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLLESGGGLVQPGGSLRLSCAASGFTFSTAAMSWVRQAPGKGLEWVSGISGSGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARELSYLYSGYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNDVSWYQQLPGTAPKLLIYKNYNRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCSAWDQRQFDVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0224", + "inn": "Abrezekimab", + "target": "IL13", + "target_uniprot": "P35225", + "format": "Fab fragment (1 H-fragment + 1 L)", + "isotype": "Fab - G1 - kappa", + "product_sku": "ICH5324", + "product_url": "https://ichor.bio/abrezekimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVTLKESGPVLVKPTETLTLTCTVSGFSLTNYHVQWIRQPPGKALEWLGVMWSDGDTSFNSVLKSRLTISRDTSKSQVVLTMTNMDPVDTATYYCARDGTIAAMDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCLASEDISNYLAWYQQKPGKAPKLLIYHTSRLQDGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYRFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 47.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.14, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0225", + "inn": "Actoxumab", + "target": "toxin A [Clostridioides difficile]", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5326", + "product_url": "https://ichor.bio/actoxumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFSFSNYGMHWVRQAPGKGLEWVALIWYDGSNEDYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARWGMVRGVIDVFDIWGQGTVVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQHKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.22, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0226", + "inn": "Afasevikumab", + "target": "IL17A", + "target_uniprot": "Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5330", + "product_url": "https://ichor.bio/afasevikumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGINWSSGGIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCARDIGGFGEFYWNFGLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVRSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPATFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.22, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0227", + "inn": "Alsevalimab", + "target": "VTCN1", + "target_uniprot": "Q7Z7D3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5339", + "product_url": "https://ichor.bio/alsevalimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSIKSGSYYWGWIRQPPGKGLEWIGNIYYSGSTYYNPSLRSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAREGSYPNQFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYHSFPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0228", + "inn": "Andecaliximab", + "target": "MMP9", + "target_uniprot": "P14780", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5345", + "product_url": "https://ichor.bio/andecaliximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLLSYGVHWVRQPPGKGLEWLGVIWTGGTTNYNSALMSRFTISKDDSKNTVYLKMNSLKTEDTAIYYCARYYYGMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSL", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVRNTVAWYQQKPGKAPKLLIYSSSYRNTGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQHYITPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0229", + "inn": "Anrukinzumab", + "target": "IL13", + "target_uniprot": "P35225", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5347", + "product_url": "https://ichor.bio/anrukinzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFISYAMSWVRQAPGKGLEWVASISSGGNTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLDGYYFGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEALGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASESVDNYGKSLMHWYQQKPGKAPKLLIYRASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0230", + "inn": "Ascrinvacumab", + "target": "ACVRL1", + "target_uniprot": "P37023", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5355", + "product_url": "https://ichor.bio/ascrinvacumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGEYYWNWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARESVAGFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0231", + "inn": "Astegolimab", + "target": "IL1RL1", + "target_uniprot": "Q01638", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5356", + "product_url": "https://ichor.bio/astegolimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFTNYWIGWVRQMPGKGLEWMGIIYPGNSDTRFSPSFQGQVTISADKSITTAYLQWSSLKASDTAMYYCARHGTSSDYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQDDNFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.45, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0232", + "inn": "Atidortoxumab", + "target": "alpha toxin", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5359", + "product_url": "https://ichor.bio/atidortoxumab-biosimilar-research-grade-ich5359", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGPGLVRPSETLSLTCAVSGYSISSGMGWGWIRQPPGKGLEWIGSIDQRGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDAGHAVDMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISRWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYVFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0233", + "inn": "Atinumab", + "target": "RTN4", + "target_uniprot": "Q9NQC3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5361", + "product_url": "https://ichor.bio/atinumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMSWVRQAPGKGLEWVATIKQDGSQKNYVDSVKGRFTISRDNAKNSLYLRLNSLRAEDTAVYYCATELFDLWGRGSLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0234", + "inn": "Atoltivimab", + "target": "Zaire Ebola virus", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5362", + "product_url": "https://ichor.bio/atoltivimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFNNYGMHWVRQAPGMGLEWVAVIWHDGSDKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARNWNLFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRITITCRASQSISTYLHWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSFSTPPINFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0235", + "inn": "Avdoralimab", + "target": "C5AR1", + "target_uniprot": "P21730", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5364", + "product_url": "https://ichor.bio/avdoralimab-biosimilar-research-grade-ich5364", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYVMHWVRQATGKGLEWVSAIDTGGGTYYADSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARDYYYYASGSYYKAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSRYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0236", + "inn": "Avizakimab", + "target": "IL21", + "target_uniprot": "Q9HBE4", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5365", + "product_url": "https://ichor.bio/avizakimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYWMHWVRQAPGQGLEWMGTIDPSDQYTIYSQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYGFAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCRASQDISNFLNWYQQKPGKAVKLLIYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGHTLPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0237", + "inn": "Axatilimab", + "target": "CSF1R", + "target_uniprot": "P07333", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5366", + "product_url": "https://ichor.bio/axatilimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVTLKESGPALVKPTQTLTLTCTFSGFSLTTYGMGVGWIRQPPGKALEWLANIWWDDDKYYNPSLKNRLTISKDTSKNQVVLTMTNMDPVDTATYYCARIGPIKYPTAPYRYFDFWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCLASEDIYDNLAWYQQKPGKAPKLLIYYASSLQDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCLQDSEYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0238", + "inn": "Azintuxizumab", + "target": "SLAMF7", + "target_uniprot": "Q9NQ25", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5367", + "product_url": "https://ichor.bio/azintuxizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMAWVRQAPGKGLEWVASINYDGSSTYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDRGYYFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSTHVPPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0239", + "inn": "Balstilimab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5369", + "product_url": "https://ichor.bio/balstilimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASNGDHWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.08, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0240", + "inn": "Bavituximab", + "target": "phosphatidylserine [Homo sapiens]", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5376", + "product_url": "https://ichor.bio/bavituximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQQSGPELEKPGASVKLSCKASGYSFTGYNMNWVKQSHGKSLEWIGHIDPYYGDTSYNQKFRGKATLTVDKSSSTAYMQLKSLTSEDSAVYYCVKGGYYGHWYFDVWGAGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASLGERVSLTCRASQDIGSSLNWLQQGPDGTIKRLIYATSSLDSGVPKRFSGSRSGSDYSLTISSLESEDFVDYYCLQYVSSPPTFGAGTKLELKRADAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0241", + "inn": "Bedinvetmab", + "target": "NGF", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5380", + "product_url": "https://ichor.bio/bedinvetmab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGDLVKPGGSLRLSCVASGFTFSSHGMHWVRQSPGKGLQWVAVINSGGSSTYYTDAVKGRFTISRDNAKNTVYLQMNSLRAEDTAMYYCAKESVGGWEQLVGPHFDYWGQGTLVIVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEAAGAPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK", + "light_chain": "QSVLTQPTSVSGSLGQRVTISCSGSTNNIGILGASWYQLFPGKAPKLLVYGNGNRPSGVPDRFSGADSGDSVTLTITGLQAEDEADYYCQSFDTTLGAHVFGGGTHLTVLGQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPVTQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.74, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0242", + "inn": "Befovacimab", + "target": "TFPI", + "target_uniprot": "P10646", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5381", + "product_url": "https://ichor.bio/befovacimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYGMDWVRQAPGKGLEWVSSIRGSRGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLYRYWFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "SYELTQPPSVSVSPGQTARITCSGDNLPKYYAHWYQQKPGQAPVVVIFYDVNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWWSSTPVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0243", + "inn": "Begelomab", + "target": "DPP4", + "target_uniprot": "P27487", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2b - kappa", + "product_sku": "ICH5382", + "product_url": "https://ichor.bio/begelomab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQSGAELVKPGASVKLSCKASGYTFRSYDINWVRQRPEQGLEWIGWIFPGDGSTKYNEKFKGKATLTTDKSSSTAYMQLSRLTSEDSAVYFCARWTVVGPGYFDVWGAGTTVTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", + "light_chain": "QIVLTQSPAIMSASPGEKVTITCSASSSVSYMNWFQQKPGTSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISRMEAEDAATYYCQQRSSYPNTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.04, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0244", + "inn": "Benufutamab", + "target": "TNFRSF10B", + "target_uniprot": "O14763", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5390", + "product_url": "https://ichor.bio/benufutamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQQSGAEVVKPGASVKLSCKASGFNIKDTFIHWVKQAPGQGLEWIGRIDPANTNTKYDPKFQGKATITTDTSSNTAYMELSSLRSEDTAVYYCVRGLYTYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHGALHNHYTQKSLSLSPG", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSISNNLHWYQQKPGQAPRLLIKFASQSITGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQGNSWPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0245", + "inn": "Bepranemab", + "target": "MAPT", + "target_uniprot": "P10636", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5391", + "product_url": "https://ichor.bio/bepranemab-biosimilar-research-grade-ich5391", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGPGLVKPSETLSLTCTVSGFSLTSNDIAWIRQPPGKGLEWMGTIWTDGSTNYNTAVQSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARHRLYYGAFDYWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSQSLEYSDGYTYLEWYLQKPGQSPQLLIYEVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQATHNPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.18, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0246", + "inn": "Berlimatoxumab", + "target": "LukGH", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5392", + "product_url": "https://ichor.bio/berlimatoxumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "ELQLQESGPGLVKPSETLSLTCTVSGGSISSGSYYWDWIRQPPGKGLEWIGNIYKSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARERGMHYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSINSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQQFDPPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0247", + "inn": "Bermekimab", + "target": "IL1A", + "target_uniprot": "P01583", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5393", + "product_url": "https://ichor.bio/bermekimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCTASGFTFSMFGVHWVRQAPGKGLEWVAAVSYDGSNKYYAESVKGRFTISRDNSKNILFLQMDSLRLEDTAVYYCARGRPKVVIPAPLAHWGQGTLVTFSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYEASNLETGVPSRFSGSGSGSDFTLTISSLQPEDFATYYCQQTSSFLLSFGGGTKVEHKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.52, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0248", + "inn": "Bersanlimab", + "target": "ICAM1", + "target_uniprot": "P05362", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5394", + "product_url": "https://ichor.bio/bersanlimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVAFIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYSGWYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYDNNNRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCQSYDSSLSAWLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0249", + "inn": "Bimagrumab", + "target": "ACVR2B", + "target_uniprot": "Q13705", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5402", + "product_url": "https://ichor.bio/bimagrumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSSYINWVRQAPGQGLEWMGTINPVSGSTSYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGGWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGSYNYVNWYQQHPGKAPKLMIYGVSKRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCGTFAGGSYYGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0250", + "inn": "Bimekizumab", + "target": "IL17A", + "target_uniprot": "Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5403", + "product_url": "https://ichor.bio/bimekizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYNMAWVRQAPGKGLEWVATITYEGRNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASPPQYYEGSIYRLWFAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "AIQLTQSPSSLSASVGDRVTITCRADESVRTLMHWYQQKPGKAPKLLIYLVSNSEIGVPDRFSGSGSGTDFRLTISSLQPEDFATYYCQQTWSDPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0251", + "inn": "Birtamimab", + "target": "SAA1", + "target_uniprot": "P0DJI8", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5404", + "product_url": "https://ichor.bio/birtamimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMYWIRQAPGKGLEWVARIRSKSNNYAIYYADSVKDRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARPYSDSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLVHSTGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0252", + "inn": "Bleselumab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5407", + "product_url": "https://ichor.bio/bleselumab-biosimilar-research-grade-ich5407", + "rrid": "", + "sequences": { + "heavy_chain": "QLQLQESGPGLLKPSETLSLTCTVSGGSISSPGYYGGWIRQPPGKGLEWIGSIYKSGSTYHNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCTRPVVRYFGWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0253", + "inn": "Blontuvetmab", + "target": "MS4A1", + "target_uniprot": "P11836", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - Vkappa-Clambda", + "product_sku": "ICH5409", + "product_url": "https://ichor.bio/blontuvetmab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQSRAELVRPGASVTLSCKPSGYTFTDYEVHWVKQTPVHGLEWIGAIDPETGGTADNQKFKGKAILTADKSSSTAYMELRSLTSEDSAVYYCTNFVDVWGTGTTVTVSSASTTAPSVFPLAPSCGSQSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQKSLSHSPGK", + "light_chain": "DVVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSGNQKNYLAWYQQKPGQSPRLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVFYCQQYYNYPLTFGGGTHLTVLGQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0254", + "inn": "Brazikumab", + "target": "IL23A", + "target_uniprot": "Q9NPF7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5413", + "product_url": "https://ichor.bio/brazikumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNEYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRGYTSSWYPDAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSSSNTGAGYDVHWYQQVPGTAPKLLIYGSGNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.12, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0255", + "inn": "Brontictuzumab", + "target": "NOTCH1", + "target_uniprot": "P46531", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5416", + "product_url": "https://ichor.bio/brontictuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKISCKVSGYTLRGYWIEWVRQAPGKGLEWIGQILPGTGRTNYNEKFKGRVTMTADTSTDTAYMELSSLRSEDTAVYYCARFDGNYGYYAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWFQQKPGQAPRTLIGGTNNRAPGVPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNHWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0256", + "inn": "Budigalimab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5417", + "product_url": "https://ichor.bio/budigalimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EIQLVQSGAEVKKPGSSVKVSCKASGYTFTHYGMNWVRQAPGQGLEWVGWVNTYTGEPTYADDFKGRLTFTLDTSTSTAYMELSSLRSEDTAVYYCTREGEGLGFGDWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSIVHSHGDTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIPVTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.75, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0257", + "inn": "Cabiralizumab", + "target": "CSF1R", + "target_uniprot": "P07333", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5419", + "product_url": "https://ichor.bio/cabiralizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDNYMIWVRQAPGQGLEWMGDINPYNGGTTFNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARESPYFSNLYVMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCKASQSVDYDGDNYMNWYQQKPGQAPRLLIYAASNLESGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHLSNEDLSTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.02, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0258", + "inn": "Carotuximab", + "target": "ENG", + "target_uniprot": "P17813", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5428", + "product_url": "https://ichor.bio/carotuximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVKLEESGGGLVQPGGSMKLSCAASGFTFSDAWMDWVRQSPEKGLEWVAEIRSKASNHATYYAESVKGRFTISRDDSKSSVYLQMNSLRAEDTGIYYCTRWRRFFDSWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWSSNPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0259", + "inn": "Cendakimab", + "target": "IL13", + "target_uniprot": "P35225", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5432", + "product_url": "https://ichor.bio/cendakimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVTLRESGPGLVKPTQTLTLTCTLYGFSLSTSDMGVDWIRQPPGKGLEWLAHIWWDDVKRYNPALKSRLTISKDTSKNQVVLKLTSVDPVDTATYYCARTVSSGYIYYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTISCRASQDIRNYLNWYQQKPGKAPKLLIFYTSKLHSGVPSRFSGSGSGTDYTLTISSLQPEDIATYYCQQGNTLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0260", + "inn": "Cetrelimab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5434", + "product_url": "https://ichor.bio/cetrelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFDTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARPGLAAAYDTGSLDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVRSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRNYWPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0261", + "inn": "Cinpanemab", + "target": "SNCA", + "target_uniprot": "P37840", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5439", + "product_url": "https://ichor.bio/cinpanemab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVEPGGSLRLSCAVSGFDFEKAWMSWVRQAPGQGLQWVARIKSTADGGTTSYAAPVEGRFIISRDDSRNMLYLQMNSLKTEDTAVYYCTSAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "SYELTQPPSVSVSPGQTARITCSGEALPMQFAHWYQQRPGKAPVIVVYKDSERPSGVPERFSGSSSGTTATLTITGVQAEDEADYYCQSPDSTNTYEVFGGGTKLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.53, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0262", + "inn": "Cobolimab", + "target": "HAVCR2", + "target_uniprot": "Q8TDQ0", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5442", + "product_url": "https://ichor.bio/cobolimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAAASGFTFSSYDMSWVRQAPGKGLDWVSTISGGGTYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSIRRYLNWYHQKPGKAPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQSHSAPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0263", + "inn": "Cofetuzumab", + "target": "PTK7", + "target_uniprot": "Q13308", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5443", + "product_url": "https://ichor.bio/cofetuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGPEVKKPGASVKVSCKASGYTFTDYAVHWVRQAPGKRLEWIGVISTYNDYTYNNQDFKGRVTMTRDTSASTAYMELSRLRSEDTAVYYCARGNSYFYALDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASESVDSYGKSFMHWYQQKPGQAPRLLIYRASNLESGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSNEDPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0264", + "inn": "Conatumumab", + "target": "TNFRSF10B", + "target_uniprot": "O14763", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5445", + "product_url": "https://ichor.bio/conatumumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGDYFWSWIRQLPGKGLEWIGHIHNSGTTYYNPSLKSRVTISVDTSKKQFSLRLSSVTAADTAVYYCARDRGGDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQGISRSYLAWYQQKPGQAPSLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0265", + "inn": "Concizumab", + "target": "TFPI", + "target_uniprot": "P10646", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5447", + "product_url": "https://ichor.bio/concizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQTPEKRLEWVATISRSGSYSYFPDSVQGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGGYDEGDAMDSWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLESDGKTYLNWYLQKPGQSPQLLIYLVSILDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQATHFPQTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.27, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0266", + "inn": "Cosfroviximab", + "target": "Zaire Ebola virus", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5450", + "product_url": "https://ichor.bio/cosfroviximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0267", + "inn": "Cosibelimab", + "target": "PD-L1", + "target_uniprot": "Q9NZQ7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5451", + "product_url": "https://ichor.bio/cosibelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGGTFSRSAISWVRQAPGQGLEWMGVIIPAFGEANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGRQMFGAGIDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "NFMLTQPHSVSESPGKTVTISCTRSSGSIDSNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSNNRHVIFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0268", + "inn": "Crenezumab", + "target": "APP", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5454", + "product_url": "https://ichor.bio/crenezumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKGLELVASINSNGGSTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASGDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLVYSNGDTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.63, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0269", + "inn": "Crotedumab", + "target": "GCGR", + "target_uniprot": "P47871", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5456", + "product_url": "https://ichor.bio/crotedumab-biosimilar-research-grade-ich5456", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYLMNWVRQAPGKGLEWLANIQEDGIEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREPSHYDILTGYDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFILTVSSLQPEDFATYYCLQYNSNPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0270", + "inn": "Crovalimab", + "target": "C5", + "target_uniprot": "P01031", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5457", + "product_url": "https://ichor.bio/crovalimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGLVQPGRSLRLSCAASGFTVHSSYYMAWVRQAPGKGLEWVGAIFTGSGAEYKAEWAKGRVTISKDTSKNQVVLTMTNMDPVDTATYYCASDAGYDYPTHAMHYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELRRGPKVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHAHYTRKELSLSP", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSSLAWYQQKPGKAPKLLIYGASETESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNTKVGSSYGNTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0271", + "inn": "Cudarolimab", + "target": "TNFRSF4", + "target_uniprot": "P43489", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5458", + "product_url": "https://ichor.bio/cudarolimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGRPWYSETGTSAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQSDHYPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0272", + "inn": "Dalotuzumab", + "target": "IGF1R", + "target_uniprot": "P06213;P08069", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5463", + "product_url": "https://ichor.bio/dalotuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGYSITGGYLWNWIRQPPGKGLEWIGYISYDGTNNYKPSLKDRVTISRDTSKNQFSLKLSSVTAADTAVYYCARYGRVFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSIVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRLYGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0273", + "inn": "Dectrekumab", + "target": "IL13", + "target_uniprot": "P35225", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5470", + "product_url": "https://ichor.bio/dectrekumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLWFGDLDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERAILSCRAGQSVSSYLVWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSSWPPVYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0274", + "inn": "Demcizumab", + "target": "DLL4", + "target_uniprot": "Q9NR61", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5472", + "product_url": "https://ichor.bio/demcizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKISCKASGYSFTAYYIHWVKQAPGQGLEWIGYISSYNGATNYNQKFKGRVTFTTDTSTSTAYMELRSLRSDDTAVYYCARDYDYDVGMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVMTQSPDSLAVSLGERATISCRASESVDNYGISFMKWFQQKPGQPPKLLIYAASNQGSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEVPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.62, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0275", + "inn": "Demupitamab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5473", + "product_url": "https://ichor.bio/demupitamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0276", + "inn": "Dezamizumab", + "target": "APCS", + "target_uniprot": "P02743", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5478", + "product_url": "https://ichor.bio/dezamizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGFTFATYNMHWVRQAPGQGLEWMGYIYPGDGNANYNQQFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGDFDYDGGYYFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASENIYSYLAWYQQKPGKAPKLLIHNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGAPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0277", + "inn": "Diridavumab", + "target": "influenza A virus hemagglutinin HA2 subunit from various strains", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5481", + "product_url": "https://ichor.bio/diridavumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0278", + "inn": "Disitamab", + "target": "ERBB2", + "target_uniprot": "P04626", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5482", + "product_url": "https://ichor.bio/disitamab-biosimilar-research-grade-ich5482", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGATVKISCKVSGYTFTDYYIHWVQQAPGKGLEWMGRVNPDHGDSYYNQKFKDKATITADKSTDTAYMELSSLRSEDTAVYFCARNYLFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCHQFATYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0279", + "inn": "Disitamab Vedotin", + "target": "ERBB2 / HER2 / CD340", + "target_uniprot": "P04626", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5482V", + "product_url": "https://ichor.bio/disitamab-vedotin-biosimilar-research-grade-ich5482v", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGATVKISCKVSGYTFTDYYIHWVQQAPGKGLEWMGRVNPDHGDSYYNQKFKDKATITADKSTDTAYMELSSLRSEDTAVYFCARNYLFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCHQFATYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0280", + "inn": "Docaravimab", + "target": "ERA", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2b - kappa", + "product_sku": "ICH5484", + "product_url": "https://ichor.bio/docaravimab-biosimilar-research-grade-ich5484", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLKESGPGLLAPSQSLSITCTVSGFSLTGHGVNWVRQPPGKGLEWLGIIWADGTTNYNSALKSRLSISKDNSKSQVFLKMNSLQTDDTASYYCAREGDISGYYFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", + "light_chain": "DVQMTQTTSSLSASLGDRVTITCRPSQDINNYLSWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDFATYFCQQGNTLPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.48, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0281", + "inn": "Domagrozumab", + "target": "MSTN", + "target_uniprot": "O14793", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5485", + "product_url": "https://ichor.bio/domagrozumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSTISSGGSYTSYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKQDYAMNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHYSTPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0282", + "inn": "Donanemab", + "target": "APP", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5487", + "product_url": "https://ichor.bio/donanemab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYDFTRYYINWVRQAPGQGLEWMGWINPGSGNTKYNEKFKGRVTITADESTSTAYMELSSLRSEDTAVYYCAREGITVYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLYSRGKTYLNWLLQKPGQSPQLLIYAVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVQGTHYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0283", + "inn": "Dovanvetmab", + "target": "Felcat IL31", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5489", + "product_url": "https://ichor.bio/dovanvetmab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVLLVQSGAEVRTPGASVKIFCKASGYSFTSYTIHWLRQAPAQGLEWMGNINPTSGYTENNQRFKDRLTLTADTSTNTAYMELSSLRSADTAMYYCARWGFKYDGEWSFDVWGAGTTVTVSSASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEAAGAPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", + "light_chain": "EIQMTQSPSSLSASPGDRVTITCRASQGISIWLSWYQQKPGNIPKVLINKASNLHIGVPSRFSGSGSGTDFTLTISSLEPEDAATYYCLQSQTYPLTFGGGTKLEIKRSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFQRSEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.77, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0284", + "inn": "Drozitumab", + "target": "TNFRSF10B", + "target_uniprot": "O14763", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda3", + "product_sku": "ICH5491", + "product_url": "https://ichor.bio/drozitumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGGGVERPGGSLRLSCAASGFTFDDYAMSWVRQAPGKGLEWVSGINWQGGSTGYADSVKGRVTISRDNAKNSLYLQMNSLRAEDTAVYYCAKILGAGRGWYFDYWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "SELTQDPAVSVALGQTVRITCSGDSLRSYYASWYQQKPGQAPVLVIYGANNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSADSSGNHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0285", + "inn": "Duligotuzumab", + "target": "ERBB3", + "target_uniprot": "P21860", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5493", + "product_url": "https://ichor.bio/duligotuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTLSGDWIHWVRQAPGKGLEWVGEISAAGGYTDYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARESRVSFEAAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQNIATDVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSEPEPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.66, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0286", + "inn": "Dusigitumab", + "target": "IGF2", + "target_uniprot": "P01344", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5494", + "product_url": "https://ichor.bio/dusigitumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYDINWVRQATGQGLEWMGWMNPNSGNTGYAQKFQGRVTMTRNTSISTAYMELSSLRSEDTAVYYCARDPYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSVSAAPGQKVTISCSGSSSNIENNHVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCETWDTSLSAGRVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.87, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0287", + "inn": "Elezanumab", + "target": "RGMA", + "target_uniprot": "Q96B86", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5512", + "product_url": "https://ichor.bio/elezanumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTSHGISWVRQAPGQGLDWMGWISPYSGNTNYAQKLQGRVTMTTDTSTSTAYMELSSLRSEDTAVYYCARVGSGPYYYMDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDQLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHNHYTQKSLSLSPGK", + "light_chain": "QSALTQPRSVSGSPGQSVTISCTGTSSSVGDSIYVSWYQQHPGKAPKLMLYDVTKRPSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCYSYAGTDTLFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0288", + "inn": "Elgemtumab", + "target": "ERBB3", + "target_uniprot": "P21860", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5513", + "product_url": "https://ichor.bio/elgemtumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAINSQGKSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARWGDEGFDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISNWLAWYQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSFPTTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0289", + "inn": "Elipovimab", + "target": "HIV-1", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5514", + "product_url": "https://ichor.bio/elipovimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QMQLQESGPGLVKPSETLSLTCSVSGASISDSYWSWIRRSPGKGLEWIGYVHKSGDTNYNPSLKSRVHLSLDTSKNQVSLSLTGVTAADSGKYYCARTLHGRRIYGIVAFNEWFTYFYMDVWGTGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLAGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPLPEEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK", + "light_chain": "SDISVAPGETARISCGEKSLGSRAVQWYQHRAGQAPSLIIYNNQDRPSGIPERFSGSPDSRPGTTATLTITSVEAGDEADYYCHIWDSRVPTKWVFGGGTTLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.91, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0290", + "inn": "Emactuzumab", + "target": "CSF1R", + "target_uniprot": "P07333", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5518", + "product_url": "https://ichor.bio/emactuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYDISWVRQAPGQGLEWMGVIWTDGGTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDQRLYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASEDVNTYVSWYQQKPGKAPKLLIYAASNRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSFSYPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0291", + "inn": "Enapotamab", + "target": "AXL", + "target_uniprot": "P30530", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5522", + "product_url": "https://ichor.bio/enapotamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTTSGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKIWIAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0292", + "inn": "Enapotamab Vedotin", + "target": "AXL / UFO", + "target_uniprot": "P30530", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5522V", + "product_url": "https://ichor.bio/enapotamab-vedotin-biosimilar-research-grade-ich5522v", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTTSGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKIWIAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0293", + "inn": "Enavatuzumab", + "target": "TNFRSF12A", + "target_uniprot": "Q9NP84", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5523", + "product_url": "https://ichor.bio/enavatuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVAEIRLKSDNYATHYAESVKGRFTISRDDSKNSLYLQMNSLRAEDTAVYYCTGYYADAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKLLIKYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWEIPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0294", + "inn": "Encelimab", + "target": "LAG3", + "target_uniprot": "P18627", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5524", + "product_url": "https://ichor.bio/encelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGATVKISCKASGFSIKDDYIHWVQQAPGKGLEWMGWIDAMNDDSQYSSKFQGRVTITVDTSTNTAYMKLSSLRSEDTAVYYCTYAFGGYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSDSNTYLHWYLQKPGQSPQLLIYLVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCGQSTHVPYAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.69, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0295", + "inn": "Enoticumab", + "target": "DLL4", + "target_uniprot": "Q9NR61", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5526", + "product_url": "https://ichor.bio/enoticumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVSFLWYDGTNKNYVESVKGRFTISRDNSKNMLYLEMNSLRAEDTAVYYCARDHDFRSGYEGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHRSNWPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0296", + "inn": "Ensituximab", + "target": "MUC5AC", + "target_uniprot": "P98088", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5527", + "product_url": "https://ichor.bio/ensituximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLKESGPDLVAPSQSLSITCTVSGFSLSKFGVNWVRQPPGKGLEWLGVIWGDGSTSYNSGLISRLSISKENSKSQVFLKLNSLQADDTATYYCVKPGGDYWGHGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGPYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTMPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QVVLTQSPVIMSASPGEKVTMTCSASSSISYMYWYQQKPGTSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISNMEAGDAATYYCHQRDSYPWTFGGGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0297", + "inn": "Etaracizumab", + "target": "ITGAV_ITGB3", + "target_uniprot": "P06756;P05106", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5534", + "product_url": "https://ichor.bio/etaracizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVAKVSSGGGSTYYLDTVQGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARHLHGSFASWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCQASQSISNFLHWYQQRPGQAPRLLIRYRSQSISGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSGSWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.44, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0298", + "inn": "Etigilimab", + "target": "TIGIT", + "target_uniprot": "Q495A1", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5536", + "product_url": "https://ichor.bio/etigilimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCAVSGYSITSDYAWNWIRQPPGKGLEWIGYISYSGSTSYNPSLRSRVTISRDTSKNQFFLKLSSVTAADTAVYYCARRQVGLGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQHYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSNTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.58, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0299", + "inn": "Favezelimab", + "target": "LAG3", + "target_uniprot": "P18627", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5545", + "product_url": "https://ichor.bio/favezelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QMQLVQSGPEVKKPGTSVKVSCKASGYTFTDYNVDWVRQARGQRLEWIGDINPNDGGTIYAQKFQERVTITVDKSTSTAYMELSSLRSEDTAVYYCARNYRWFGAMDHWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCKASQSLDYEGDSDMNWYLQKPGQPPQLLIYGASNLESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQSTEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.02, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0300", + "inn": "Felzartamab", + "target": "CD38", + "target_uniprot": "P28907", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5547", + "product_url": "https://ichor.bio/felzartamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFSSYYMNWVRQAPGKGLEWVSGISGDPSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLPLVYTGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIELTQPPSVSVAPGQTARISCSGDNLRHYYVYWYQQKPGQAPVLVIYGDSKRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCQTYTGGASLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0301", + "inn": "Fianlimab", + "target": "LAG3", + "target_uniprot": "P18627", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5548", + "product_url": "https://ichor.bio/fianlimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCVASGFTFSSYGMHWVRQAPGKGLEWVAIIWYDGSNKYYADSVKGRFTISRDNSKNTQYLQMNSLRAEDTAVYYCASVATSGDFDYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERTTLSCRASQRISTYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTGFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0302", + "inn": "Firivumab", + "target": "influenza A virus hemagglutinin HA [Influenza A virus]", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5551", + "product_url": "https://ichor.bio/firivumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKMPGSSVKVSCKTSGVFFSSHAISWVRQAPGQGLEWMGGISPMFGTTHYAQKFQGRVTITADQSTTTAYMELTSLTSEDTAVYYCARDGAGSYYPLNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASENIWNNLAWYQQKPGQAPRLLISGASTGATGVPSRFRGSGSRTEFTLTISSLQSEDFAIYFCQQYNSWPRTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.22, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0303", + "inn": "Flanvotumab", + "target": "TYRP1", + "target_uniprot": "P17643", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5553", + "product_url": "https://ichor.bio/flanvotumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGSELKKPGASVKISCKASGYTFTSYAMNWVRQAPGQGLESMGWINTNTGNPTYAQGFTGRFVFSMDTSVSTAYLQISSLKAEDTAIYYCAPRYSSSWYLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWLMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0304", + "inn": "Foravirumab", + "target": "RABV", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5555", + "product_url": "https://ichor.bio/foravirumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGAVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVILYDGSDKFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKVAVAGTHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQLNSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0305", + "inn": "Frovocimab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5558", + "product_url": "https://ichor.bio/frovocimab-biosimilar-research-grade-ich5558", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFPFSKLGMVWVRQAPGKGLEWVSTISSGGGYTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGISFQGGTYTYVMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSKSLLHRNGITYSYWYLQKPGQSPQLLIYQLSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCYQNLELPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.09, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0306", + "inn": "Frunevetmab", + "target": "Felcat NGF", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5559", + "product_url": "https://ichor.bio/frunevetmab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGAELVQPGESLRLTCAASGFSLTNNNVNWVRQAPGKGLEWMGGVWAGGATDYNSALKSRLTITRDTSKNTVFLQMHSLQSEDTATYYCARDGGYSSSTLYAMDAWGQGTTVTVSAASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", + "light_chain": "DIEMTQSPLSLSVTPGESVSISCRASEDIYNALAWYLQKPGRSPRLLIYNTDTLHTGVPDRFSGSGSGTDFTLKISRVQTEDVGVYFCQHYFHYPRTFGQGTKLELKRSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFNRSECQRE", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 148.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0307", + "inn": "Futuximab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5560", + "product_url": "https://ichor.bio/futuximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQQPGSELVRPGASVKLSCKASGYTFTSYWMHWVKQRPGQGLEWIGNIYPGSRSTNYDEKFKSKATLTVDTSSSTAYMQLSSLTSEDSAVYYCTRNGDYYVSSGDAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQTTSSLSASLGDRVTISCRTSQDIGNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDFSLTINNVEQEDVATYFCQHYNTVPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.16, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0308", + "inn": "Garadacimab", + "target": "F12", + "target_uniprot": "P00748", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - lambda", + "product_sku": "ICH5563", + "product_url": "https://ichor.bio/garadacimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSKYIMQWVRQAPGKGLEWVSGIDIPTKGTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARALPRSGYLISPHYYYYALDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGRNYVYWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDASLRGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0309", + "inn": "Garetosmab", + "target": "INHBA", + "target_uniprot": "P08476", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5564", + "product_url": "https://ichor.bio/garetosmab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGGSFSSHFWSWIRQPPGKGLEWIGYILYTGGTSFNPSLKSRVSMSVGTSKNQFSLKLSSVTAADTAVYYCARARSGITFTGIIVPGSFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.08, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0310", + "inn": "Gatipotuzumab", + "target": "MUC1", + "target_uniprot": "P15941", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5566", + "product_url": "https://ichor.bio/gatipotuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSMRLSCVASGFPFSNYWMNWVRQAPGKGLEWVGEIRLKSNNYTTHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCTRHYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSNPVTPGEPASISCRSSKSLLHSNGITYFFWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLRISRVEAEDVGVYYCAQNLELPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0311", + "inn": "Gatralimab", + "target": "CD52", + "target_uniprot": "P31358", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5567", + "product_url": "https://ichor.bio/gatralimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFPFSNYWMNWVRQAPGKGLEWVGQIRLKSNNYATHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCTPIDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLYSNGKTYLNWVLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVQGSHFHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0312", + "inn": "Gedivumab", + "target": "influenza A virus hemagglutinin HA [Influenza A virus]", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5569", + "product_url": "https://ichor.bio/gedivumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGVVQPGKSLRLSCAASGLTFSSYAVHWVRQAPGKGLEWVTLISYDGANQYYADSVKGRFTISRDNSKNTVYLQMNSLRPEDTAVYYCAVPGPVFGIFPPWSYFDNWGQGILVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSVSPGERATLSCRASQVISHNLAWYQQKPGQAPRLLIYGASTRASGIPARFSGSGSGTDYTLTITSLQSEDFAVYYCQHYSNWPPRLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0313", + "inn": "Giloralimab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5571", + "product_url": "https://ichor.bio/giloralimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGPGLVKPSETLSLTCTVSGYSITSNYYWNWIRQPPGKGLEWMGYIRYDGSNNYNPSLKNRVTISRDTSKNQFSLKLSSVTAADTAVYYCARLDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEEKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSQSLENTNGNTFLNWYLQKPGQSPQLLIYRVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQVTHVPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0314", + "inn": "Gilvetmab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5572", + "product_url": "https://ichor.bio/gilvetmab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGGDLVKPGGSVRLSCVASGFNIKNTYMHWVRQAPGKGLQWIGRIAPANVDTKYAPKFQGKATISADTAKNTAYMQLNSLRAEDTAVYYCVLIYYDYDGDIDVWGQGTLVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVALDPEDPEVQISWFVDGKQMQTAKTQPREEQFAGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK", + "light_chain": "DIVMTQTPLSLSVSLGEPASISCHASQNINVWLSWYRQKPGQIPQLLIYKASHLHTGVPDRFSGSGSGTDFTLRISRVEADDAGVYYCQQGQSWPLTFGQGTKVEIKRNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDSKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 148.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.58, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0315", + "inn": "Gimsilumab", + "target": "CSF2", + "target_uniprot": "P04141", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5574", + "product_url": "https://ichor.bio/gimsilumab-biosimilar-research-grade-ich5574", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRHWMHWLRQVPGKGPVWVSRINGAGTSITYADSVRGRFTISRDNANNTLFLQMNSLRADDTALYFCARANSVWFRGLFDYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVVHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPVTLSVSPGERVTLSCRASQSVSTNLAWYQQKLGQGPRLLIYGASTRATDIPARFSGSGSETEFTLTISSLQSEDFAVYYCQQYDKWPDTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.34, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0316", + "inn": "Glembatumumab Vedotin", + "target": "GPNMB", + "target_uniprot": "Q14956", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-Kappa", + "product_sku": "ICH5575V", + "product_url": "https://ichor.bio/glembatumumab-vedotin-biosimilar-research-grade-ich5575v", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSFNYYWSWIRHHPGKGLEWIGYIYYSGSTYSNPSLKSRVTISVDTSKNQFSLTLSSVTAADTAVYYCARGYNWNYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVDNNLVWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.87, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0317", + "inn": "Glenzocimab", + "target": "GP6", + "target_uniprot": "Q9HCN6", + "format": "Fab fragment (1 H-fragment + 1 L)", + "isotype": "Fab - G1 - kappa", + "product_sku": "ICH5576", + "product_url": "https://ichor.bio/glenzocimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGGIYPGNGDTSYNQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGTVVGDWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLENSNGNTYLNWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQLTHVPWTFGQGTKVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 48.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.57, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0318", + "inn": "Gosuranemab", + "target": "MAPT", + "target_uniprot": "P10636", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5582", + "product_url": "https://ichor.bio/gosuranemab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVHLVESGGALVKPGGSLRLSCAASGFSFSKYGMSWVRQAPGKGLEWVATISSSGSRTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAMYYCSISWDGAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSIVHSNGNTYLEWYLQKPGQSPQLLVYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGTYYCFQGSLVPWAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0319", + "inn": "Ianalumab", + "target": "TNFRSF13C", + "target_uniprot": "Q96RJ3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5587", + "product_url": "https://ichor.bio/ianalumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWGWIRQSPGRGLEWLGRIYYRSKWYNSYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARYDWVPKIGVFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVLTQSPATLSLSPGERATLSCRASQFISSSYLSWYQQKPGQAPRLLIYGSSSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQLYSSPMTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0320", + "inn": "Icrucumab", + "target": "FLT1", + "target_uniprot": "P17948", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5589", + "product_url": "https://ichor.bio/icrucumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QAQVVESGGGVVQSGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSENTLYLQMNSLRAEDTAVYYCARDHYGSGVHHYFYYGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0321", + "inn": "Ifabotuzumab", + "target": "EPHA3", + "target_uniprot": "P29320", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5591", + "product_url": "https://ichor.bio/ifabotuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYWMNWVRQAPGQGLEWMGDIYPGSGNTNYDEKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGGYYEDFDSWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSFLSASVGDRVTITCRASQGIISYLAWYQQKPEKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCGQYANYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0322", + "inn": "Iladatuzumab", + "target": "CD79B", + "target_uniprot": "P40259", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5593", + "product_url": "https://ichor.bio/iladatuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSSCSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.63, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0323", + "inn": "Iladatuzumab Vedotin", + "target": "CD79b", + "target_uniprot": "P40259", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5593V", + "product_url": "https://ichor.bio/iladatuzumab-vedotin-biosimilar-research-grade-ich5593v", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSSCSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.63, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0324", + "inn": "Imalumab", + "target": "MIF", + "target_uniprot": "P14174", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5595", + "product_url": "https://ichor.bio/imalumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSIYSMNWVRQAPGKGLEWVSSIGSSGGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGSQWLYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQRIMTYLNWYQQKPGKAPKLLIFVASHSQSGVPSRFRGSGSETDFTLTISGLQPEDSATYYCQQSFWTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0325", + "inn": "Imaprelimab", + "target": "MCAM", + "target_uniprot": "P43121", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5596", + "product_url": "https://ichor.bio/imaprelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVTLKESGPVLVKPTETLTLTCTVSGFSLTSNAVSWVRQPPGKALEWIAAISSGGTTYYNSAFKSRLTISRDTSKSQVVLTMTNMDPVDTATYYCARRYGYGWYFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTINCKASQNIYNSLAWYQQKPGKAPKVLIFNANSLQTGIPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFYSGYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0326", + "inn": "Imgatuzumab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5600", + "product_url": "https://ichor.bio/imgatuzumab-biosimilar-research-grade-ich5600", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGFTFTDYKIHWVRQAPGQGLEWMGYFNPNSGYSTYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSPGGYYVMDAWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGINNYLNWYQQKPGKAPKRLIYNTNNLQTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSFPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.5, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0327", + "inn": "Inclacumab", + "target": "SELP", + "target_uniprot": "P16109", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5602", + "product_url": "https://ichor.bio/inclacumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVRPGGSLRLSCAASGFTFSNYDMHWVRQATGKGLEWVSAITAAGDIYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGRYSGSGSYYNDWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0328", + "inn": "Indusatumab Vedotin", + "target": "GUCY2C", + "target_uniprot": "P25092", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1(E356D/M358L)-Kappa", + "product_sku": "ICH5604V", + "product_url": "https://ichor.bio/indusatumab-vedotin-biosimilar-research-grade-ich5604v", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVFGGSFSGYYWSWIRQPPGKGLEWIGEINHRGNTNDNPSLKSRVTISVDTSKNQFALKLSSVTAADTAVYYCARERGYTYGNFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSRNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTIGSLQSEDFAVYYCQQYKTWPRTFGQGTNVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0329", + "inn": "Intetumumab", + "target": "ITGAV_ITGB3", + "target_uniprot": "P06756;P05106", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5608", + "product_url": "https://ichor.bio/intetumumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSRRLSCAASGFTFSRYTMHWVRQAPGKGLEWVAVISFDGSNKYYVDSVKGRFTISRDNSENTLYLQVNILRAEDTAVYYCAREARGSYAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0330", + "inn": "Iscalimab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5610", + "product_url": "https://ichor.bio/iscalimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYEESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIAAPGPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSLTVTPGEPASISCRSSQSLLYSNGYNYLDWYLQKPGQSPQVLISLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQARQTPFTFGPGTKVDIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.08, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0331", + "inn": "Itolizumab", + "target": "CD6", + "target_uniprot": "P30203", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5611", + "product_url": "https://ichor.bio/itolizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLKLSCAASGFKFSRYAMSWVRQAPGKRLEWVATISSGGSYIYYPDSVKGRFTISRDNVKNTLYLQMSSLRSEDTAMYYCARRDYDLDYFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASRDIRSYLTWYQQKPGKAPKTLIYYATSLADGVPSRFSGSGSGQDYSLTISSLESDDTATYYCLQHGESPFTLGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0332", + "inn": "Labetuzumab Govitecan", + "target": "CEACAM5 / CEA / CD66e", + "target_uniprot": "P06731", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5617G", + "product_url": "https://ichor.bio/labetuzumab-govitecan-biosimilar-research-grade-ich5617g", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCSASGFDFTTYWMSWVRQAPGKGLEWIGEIHPDSSTINYAPSLKDRFTISRDNAKNTLFLQMDSLRPEDTGVYFCASLYFGFPWFAYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQDVGTSVAWYQQKPGKAPKLLIYWTSTRHTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYSLYRSFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0333", + "inn": "Lacnotuzumab", + "target": "CSF1", + "target_uniprot": "P09603", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5618", + "product_url": "https://ichor.bio/lacnotuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSDYSITSDYAWNWIRQFPGKGLEWMGYISYSGSTSYNPSLKSRITISRDTSKNQFSLQLNSVTAADTAVYYCASFDYAHAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVLTQSPAFLSVTPGEKVTFTCQASQSIGTSIHWYQQKTDQAPKLLIKYASESISGIPSRFSGSGSGTDFTLTISSVEAEDAADYYCQQINSWPTTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0334", + "inn": "Lacutamab", + "target": "KIR3DL2", + "target_uniprot": "P43630", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5619", + "product_url": "https://ichor.bio/lacutamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QIQLVQSGSELKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWIGWINSHSGVPKYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYFCARGGDEGVMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPEEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSFLSASVGDRVTITCKASQDVSTAVAWYQQKPGQPPKLLIYWTSTRHTGVPDRFSGSGSGTDYTLTISSLQAEDVAVYYCQQHYSTPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0335", + "inn": "Ladiratuzumab", + "target": "SLC39A6", + "target_uniprot": "Q13433", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5620", + "product_url": "https://ichor.bio/ladiratuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGLTIEDYYMHWVRQAPGQGLEWMGWIDPENGDTEYGPKFQGRVTMTRDTSINTAYMELSRLRSDDTAVYYCAVHNAHYGTWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLLHSSGNTYLEWYQQRPGQSPRPLIYKISTRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0336", + "inn": "Ladiratuzumab Vedotin", + "target": "LIV-1 / SLC39A6", + "target_uniprot": "Q13433", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5620V", + "product_url": "https://ichor.bio/ladiratuzumab-vedotin-biosimilar-research-grade-ich5620v", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGLTIEDYYMHWVRQAPGQGLEWMGWIDPENGDTEYGPKFQGRVTMTRDTSINTAYMELSRLRSDDTAVYYCAVHNAHYGTWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLLHSSGNTYLEWYQQRPGQSPRPLIYKISTRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0337", + "inn": "Lampalizumab", + "target": "CFD", + "target_uniprot": "P00746", + "format": "Fab fragment (1 H-fragment + 1 L)", + "isotype": "Fab - G1 - kappa", + "product_sku": "ICH5622", + "product_url": "https://ichor.bio/lampalizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGGVNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQVTQSPSSLSASVGDRVTITCITSTDIDDDMNWYQQKPGKVPKLLISGGNTLRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 47.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.64, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0338", + "inn": "Landogrozumab", + "target": "MSTN", + "target_uniprot": "O14793", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5624", + "product_url": "https://ichor.bio/landogrozumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGLTFSRYPMSWVRQAPGKGLVWVSAITSSGGSTYYSDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARLPDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASSSVSSSYLHWYQQKPGQAPRLLIYSTSNLVAGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHHSGYHFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0339", + "inn": "Laprituximab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5626", + "product_url": "https://ichor.bio/laprituximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVAKPGASVKLSCKASGYTFTSYWMQWVKQRPGQGLECIGTIYPGDGDTTYTQKFQGKATLTADKSSSTAYMQLSSLRSEDSAVYYCARYDAPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDINNYLAWYQHKPGKGPKLLIHYTSTLHPGIPSRFSGSGSGRDYSFSISSLEPEDIATYYCLQYDNLLYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.87, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0340", + "inn": "Laprituximab Emtansine", + "target": "ERBB1 / EGFR / HER1", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5626E", + "product_url": "https://ichor.bio/laprituximab-emtansine-biosimilar-research-grade-ich5626e", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVAKPGASVKLSCKASGYTFTSYWMQWVKQRPGQGLECIGTIYPGDGDTTYTQKFQGKATLTADKSSSTAYMQLSSLRSEDSAVYYCARYDAPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDINNYLAWYQHKPGKGPKLLIHYTSTLHPGIPSRFSGSGSGRDYSFSISSLEPEDIATYYCLQYDNLLYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.87, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0341", + "inn": "Larcaviximab", + "target": "Zaire Ebola virus", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5627", + "product_url": "https://ichor.bio/larcaviximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGPELEMPGASVKISCKASGSSFTGFSMNWVKQSNGKSLEWIGNIDTYYGGTTYNQKFKGKATLTVDKSSSTAYMQLKSLTSEDSAVYYCARSAYYGSTFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNAKTLIEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYFCQHHFGTPFTFGSGTELEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0342", + "inn": "Lenvervimab", + "target": "HBV", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5632", + "product_url": "https://ichor.bio/lenvervimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCSASGFSLTKYKMTWVRQAPGKGLEWVSSISSTSRDIDYADSVKGRFTISRDNAKNSLFLQMSSLRVDDTAVYYCTRDGWLWGWDVRSNYYYNALDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVVTQSPSSLSASVGDRVTITCRASQGIYNSIAWYQQKPGKAPKLLLYSTSTLLSGVPSRFSGSGSGTDYTLTITNLQPEDFATYYCQQYFVTPETFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0343", + "inn": "Leronlimab", + "target": "CCR5", + "target_uniprot": "P51681", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5634", + "product_url": "https://ichor.bio/leronlimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGYTFSNYWIGWVRQAPGKGLEWIGDIYPGGNYIRNNEKFKDKTTLSADTSKNTAYLQMNSLKTEDTAVYYCGSSFGSNYVFAWFTYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQRLLSSYGHTYLHWYLQKPGQSPQLLIYEVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.12, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0344", + "inn": "Lesofavumab", + "target": "influenza B virus hemagglutinin [Influenza B virus]", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5637", + "product_url": "https://ichor.bio/lesofavumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKVSGYSFTSQWIGWVRQMPGKGLEWIGMMYPGESETIYSPSFQGQVTISADNSISTAYLQWSSLKASDTAIYYCASGPGYSGYHYGWFDTWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLRSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQALQTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0345", + "inn": "Levilimab", + "target": "IL6R", + "target_uniprot": "P08887", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5639", + "product_url": "https://ichor.bio/levilimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGGGLVQPGGSLRLSCAASGFTFSSYYMSWVRQAPGKGLEWVSGIYSDGTTHYGDSVKGRFTISRDNAKNTVYLQLNSLRAEDTAMYYCAKGAGPTWWYALDAWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPPVAGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSSVSVSVGERVTIDCKSSQSVLSASNTYLNWYQQKPGQAPQLLIYYASTRESGVPDRFSGSGSGTDFTLTISSLQAEDAAVYYCQQAYRAPVTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0346", + "inn": "Lexatumumab", + "target": "TNFRSF10B", + "target_uniprot": "O14763", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5640", + "product_url": "https://ichor.bio/lexatumumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGGGVERPGGSLRLSCAASGFTFDDYGMSWVRQAPGKGLEWVSGINWNGGSTGYADSVKGRVTISRDNAKNSLYLQMNSLRAEDTAVYYCAKILGAGRGWYFDLWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0347", + "inn": "Ligelizumab", + "target": "IGHE", + "target_uniprot": "P01854", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5644", + "product_url": "https://ichor.bio/ligelizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVMKPGSSVKVSCKASGYTFSWYWLEWVRQAPGHGLEWMGEIDPGTFTTNYNEKFKARVTFTADTSTSTAYMELSSLRSEDTAVYYCARFSHFSGSNYDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSIGTNIHWYQQKPGQAPRLLIYYASESISGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQSWSWPTTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.16, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0348", + "inn": "Lilotomab", + "target": "CD37", + "target_uniprot": "P11049", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5645", + "product_url": "https://ichor.bio/lilotomab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EIQLQQSGPELVKPGASVKVSCKASGYSFTDYNMYWVKQSHGKSLEWIGYIDPYNGDTTYNQKFKGKATLTVDKSSSTAFIHLNSLTSEDSAVYYCARSPYGHYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", + "light_chain": "DIVMTQSHKLLSTSVGDRVSITCKASQDVSTAVDWYQQKPGQSPKLLINWASTRHTGVPDRFTGSGSGTDYTLTISSMQAEDLALYYCRQHYSTPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0349", + "inn": "Lodapolimab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda", + "product_sku": "ICH5651", + "product_url": "https://ichor.bio/lodapolimab-biosimilar-research-grade-ich5651", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARSPDYSPYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCQSYDSSLSGSVFGGGIKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPAECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0350", + "inn": "Lodelcizumab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5652", + "product_url": "https://ichor.bio/lodelcizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFSTMYMSWVRQAPGQGLEWMGRIDPANEHTNYAQKFQGRVTMTRDTSISTAYMELSRLTSDDTAVYYCARSYYYYNMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QIVLTQSPATLSVSPGERATLSCRASQSVSYMHWYQQKPGQAPRLLIYGVFRRATGIPDRFSGSGSGTDFTLTIGRLEPEDFAVYYCLQWSSDPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0351", + "inn": "Lokivetmab", + "target": "IL31", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5653", + "product_url": "https://ichor.bio/lokivetmab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGDLVKPGGSLRLSCVASGFTFSNYGMSWVRQAPGKGLQWVATISYGGSYTYYPDNIKGRFTISRDNAKNTLYLQMNSLRAEDTAMYYCVRGYGYDTMDYWGQGTLVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPG", + "light_chain": "EIVMTQSPASLSLSQEEKVTITCKASQSVSFAGTGLMHWYQQKPGQAPKLLIYRASNLEAGVPSRFSGSGSGTDFSFTISSLEPEDVAVYYCQQSREYPWTFGQGTKLEIKRNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.11, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0352", + "inn": "Losatuxizumab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5657", + "product_url": "https://ichor.bio/losatuxizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGPGLVKPSQTLSLTCTVSGYSISRDFAWNWIRQPPGKGLEWMGYISYNGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTASRGFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSMSVSVGDRVTITCHSSQDINSNIGWLQQKPGKSFKGLIYHGTNLDDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCVQYAQFPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0353", + "inn": "Lumretuzumab", + "target": "ERBB3", + "target_uniprot": "P21860", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5660", + "product_url": "https://ichor.bio/lumretuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFRSSYISWVRQAPGQGLEWMGWIYAGTGSPSYNQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARHRDYYSNSLTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQSDYSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0354", + "inn": "Lupartumab", + "target": "LYPD3", + "target_uniprot": "O95274", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5663", + "product_url": "https://ichor.bio/lupartumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVSYISSSGSTIYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAREGLWAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "ESVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYVVHWYQQLPGTAPKLLIYDNNKRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDRLNGPVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0355", + "inn": "Maftivimab", + "target": "Zaire Ebola virus", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5666", + "product_url": "https://ichor.bio/maftivimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTSSSYAMNWVRQAPGKGLEWVSTISGMGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKRGYPHSFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSFLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0356", + "inn": "Manelimab", + "target": "PD-L1", + "target_uniprot": "Q9NZQ7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5667", + "product_url": "https://ichor.bio/manelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGVVRPGGSLRLSCAASGFTFDDYAMSWVRQAPGKGLEWVSDISWSGSNTNYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYHCARAPLLLAMTFGVGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QTVVTQEPSLSVSPGGTVTLTCGLSSGTVTAINYPGWYQQTPGQAPRTLIYNTNTRHSGVPDRFSGSISGNKAALTITGAQAEDEADYYCALYMGNGGHMFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.91, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0357", + "inn": "Marstacimab", + "target": "TFPI", + "target_uniprot": "P10646", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5671", + "product_url": "https://ichor.bio/marstacimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAILGATSLSAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGSGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0358", + "inn": "Mezagitamab", + "target": "CD38", + "target_uniprot": "P28907", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda", + "product_sku": "ICH5679", + "product_url": "https://ichor.bio/mezagitamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFDDYGMSWVRQAPGKGLEWVSDISWNGGKTHYVDSVKGQFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGSLFHDSSGFYFGHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGDNYVSWYQQLPGTAPKLLIYRDSQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0359", + "inn": "Milatuzumab", + "target": "CD74", + "target_uniprot": "P04233", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5681", + "product_url": "https://ichor.bio/milatuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGVNWIKQAPGQGLQWMGWINPNTGEPTFDDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCSRSRGKNEAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPLSLPVTLGQPASISCRSSQSLVHRNGNTYLHWFQQRPGQSPRLLIYTVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSSHVPPTFGAGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.52, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0360", + "inn": "Mirikizumab", + "target": "IL23A", + "target_uniprot": "Q9NPF7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5683", + "product_url": "https://ichor.bio/mirikizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYKFTRYVMHWVRQAPGQGLEWMGYINPYNDGTNYNEKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNWDTGLWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASDHILKFLTWYQQKPGKAPKLLIYGATSLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQMYWSTPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0361", + "inn": "Mirococept", + "target": "complement C3b, C4b [Homo sapiens]", + "target_uniprot": "P0C0L5", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "Conjugate - CR1 (complement receptor type 1, C3b/C4b receptor, C3BR, Knops blood group, KN, CD35) 41-238_peptidyl-myristoylated", + "product_sku": "ICH5684", + "product_url": "https://ichor.bio/mirococept-biosimilar-research-grade-ich5684", + "rrid": "", + "sequences": { + "heavy_chain": "DIQMTQSPSSLSASVGDRVTITCKASQNVGTNVAWYQQKPGKAPKALIYSASFLYSGVPYRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "AKTIAYDEEARRGLERGLNALADAVKVTLGKWGAPTITNDGVSIAKEIELEDPYEKIGAEPKGRNVVLEKLVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKGDQSIGDLIAAVEKVTETLLKGAKEVETKEQIAATAAISAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDFHMHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQ", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 254.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 5.23, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0362", + "inn": "Miromavimab", + "target": "ERA", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5685", + "product_url": "https://ichor.bio/miromavimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQPGSVLVRPGASVKLSCKTSGYAFTSSWMHWAKQRPGQGLEWIGQTHPNSGYTNYNEKFKGKATLTVDTSSSTAYVDLSSLTSEDSAVYYCARESGDGPHWYFDVWGAGTAVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", + "light_chain": "DIVMTQSHKFMSTSVGDRVSITCKASQDVSTAVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSSPHTFGGGTKLETKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0363", + "inn": "Mirzotamab", + "target": "CD276", + "target_uniprot": "Q5ZPR3", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5687", + "product_url": "https://ichor.bio/mirzotamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGPGLVKPSETLSLTCAVTGYSITSGYSWHWIRQFPGNGLEWMGYIHSSGSTNYNPSLKSRISISRDTSKNQFFLKLSSVTAADTAVYYCAGYDDYFEYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQNVGFNVAWYQQKPGKSPKALIYSASYRYSGVPSRFSGSGSGTDFTLTISSLQPEDFAEYFCQQYNWYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0364", + "inn": "Mitazalimab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5689", + "product_url": "https://ichor.bio/mitazalimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYGMHWVRQAPGKGLEWLSYISGGSSYIFYADSVRGRFTISRDNSENALYLQMNSLRAEDTAVYYCARILRGGSGMDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCTGSSSNIGAGYNVYWYQQLPGTAPKLLIYGNINRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDKSISGLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0365", + "inn": "Modotuximab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5691", + "product_url": "https://ichor.bio/modotuximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQPGAELVEPGGSVKLSCKASGYTFTSHWMHWVKQRPGQGLEWIGEINPSSGRNNYNEKFKSKATLTVDKSSSTAYMQFSSLTSEDSAVYYCVRYYGYDEAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIVMTQAAFSNPVTLGTSASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSSSGSGTDFTLRISRVEAEDVGVYYCAQNLELPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0366", + "inn": "Murlentamab", + "target": "AMHR2", + "target_uniprot": "Q16671", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5694", + "product_url": "https://ichor.bio/murlentamab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVRLVQSGAEVKKPGASVKVSCKASGYTFTSYHIHWVRQAPGQRLEWMGWIYPGDDSTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCTRGDRFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASSSVRYIAWYQQKPGKAPKLLTYPTSSLKSGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCLQWSSYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.76, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0367", + "inn": "Namilumab", + "target": "CSF2", + "target_uniprot": "P04141", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5697", + "product_url": "https://ichor.bio/namilumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKAFGYPFTDYLLHWVRQAPGQGLEWVGWLNPYSGDTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCTRTTLISVYFDYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSVSASVGDRVTIACRASQNIRNILNWYQQRPGKAPQLLIYAASNLQSGVPSRFSGSGSGTDFTLTINSLQPEDFATYYCQQSYSMPRTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0368", + "inn": "Naratuximab", + "target": "CD37", + "target_uniprot": "P11049", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5698", + "product_url": "https://ichor.bio/naratuximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQVQESGPGLVAPSQTLSITCTVSGFSLTTSGVSWVRQPPGKGLEWLGVIWGDGSTNYHPSLKSRLSIKKDHSKSQVFLKLNSLTAADTATYYCAKGGYSLAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSVSVGERVTITCRASENIRSNLAWYQQKPGKSPKLLVNVATNLADGVPSRFSGSGSGTDYSLKINSLQPEDFGTYYCQHYWGTTWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0369", + "inn": "Narnatumab", + "target": "MST1R", + "target_uniprot": "Q04912", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5699", + "product_url": "https://ichor.bio/narnatumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYLMTWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLNLQMNSLRAEDTAVYYCTRDGYSSGRHYGMDVWGQGTTVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSRYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0370", + "inn": "Narsoplimab", + "target": "MASP2", + "target_uniprot": "O00187", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - lambda2", + "product_sku": "ICH5700", + "product_url": "https://ichor.bio/narsoplimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVTLKESGPVLVKPTETLTLTCTVSGFSLSRGKMGVSWIRQPPGKALEWLAHIFSSDEKSYRTSLKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCARIRRGGIDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "QPVLTQPPSLSVSPGQTASITCSGEKLGDKYAYWYQQKPGQSPVLVMYQDKQRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTAVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0371", + "inn": "Navivumab", + "target": "influenza A virus hemagglutinin HA [Influenza A virus]", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5702", + "product_url": "https://ichor.bio/navivumab-biosimilar-research-grade-ich5702", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKTSGYSFSTYGVSWVRQAPGQGPEWVGWISAYTGITDYAQKFQGRVTLTTDATTATAFLDLRSLRPDDTATYFCARDKVQGRVEVGSGGRHDYWGQGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", + "light_chain": "EVVLTQSPGTLALPPGERATLSCRASHRVGSTYIAWYQQKSGQAPRRLIYGASNRATDIPDRFSGSGSGTDFTLTIRRLEPEDSAVYYCQQFSVSPWTFGQGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0372", + "inn": "Netakimab", + "target": "IL17A", + "target_uniprot": "Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5709", + "product_url": "https://ichor.bio/netakimab-biosimilar-research-grade-ich5709", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGGGLVQAGGSLRLSCAASGGTFATSPMGWLRQAPGKGTEFVAAISPSGGDRIYADSVKGRFTISRDNAGYFIYLQMNSLKPEDTAVYYCAVRRRFDGTSYYTGDYDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYSYSPVTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0373", + "inn": "Nimacimab", + "target": "CNR1", + "target_uniprot": "P21554", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5711", + "product_url": "https://ichor.bio/nimacimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYEFSYYWMNWVRQAPGQGLEWMGQIYPGDGETKYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARSHGNYLPYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSSYLHWYQQKPGQAPRLLIYSTSNLASGIPARFSGSGSGTDFTLTISRLEPEDFAVYYCHQYHRSPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0374", + "inn": "Nirsevimab", + "target": "RSV", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5712", + "product_url": "https://ichor.bio/nirsevimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0375", + "inn": "Nurulimab", + "target": "CTLA4", + "target_uniprot": "P16410", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5717", + "product_url": "https://ichor.bio/nurulimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0376", + "inn": "Obexelimab", + "target": "CD19", + "target_uniprot": "P15391;P51677", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5719", + "product_url": "https://ichor.bio/obexelimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKYNEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVEHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKAFPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLNSGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0377", + "inn": "Ocaratuzumab", + "target": "MS4A1", + "target_uniprot": "P11836", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5721", + "product_url": "https://ichor.bio/ocaratuzumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGRTFTSYNMHWVRQMPGKGLEWMGAIYPLTGDTSYNQKSKLQVTISADKSISTAYLQWSSLKASDTAMYYCARSTYVGGDWQFDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKIKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKQKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASSSVPYIHWYQQKPGQAPRLLIYATSALASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQWLSNPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0378", + "inn": "Odesivimab", + "target": "Zaire Ebola virus", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5723", + "product_url": "https://ichor.bio/odesivimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYDMHWVRQATGKGLEWVSAIGTAGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARTWFGELYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTEFTLTITSLQAEDVAVYYCQQYYSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0379", + "inn": "Olendalizumab", + "target": "C5", + "target_uniprot": "P01031", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2-G4 - kappa", + "product_sku": "ICH5727", + "product_url": "https://ichor.bio/olendalizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYSMDWVRQAPGQGLEWMGAIHLNTGYTNYNQKFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGFYDGYSPMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASESVDSYGNSFMHWYQQKPGKAPKLLIYRASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.45, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0380", + "inn": "Olinvacimab", + "target": "KDR", + "target_uniprot": "P35968", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - Vlambda-Ckappa", + "product_sku": "ICH5729", + "product_url": "https://ichor.bio/olinvacimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QMQLVQSGAEVKKPGASVKLSCKASGYTFSSYWMHWVRQAPGQRLEWMGEINPGNGHTNYNEKFKSRVTITVDKSASTAYMELSSLRSEDTAVYYCAKIWGPSLTSPFDYWGQGTLVTVSSGLGGLASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "NFMLTQPPSVSVSPGKTARITCRGDNLGDVNVHWYQQRPGQAPVLVMYYDADRPSGIPERFSGSNSGNTATLTISGVEAGDEADYYCQVWDRTSEYVFGTGTKVTVLGGGASLVERSVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 148.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.68, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0381", + "inn": "Ongericimab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5733", + "product_url": "https://ichor.bio/ongericimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGFSISSYGIHWIRQSPGKGLEWIGVIWRGGITDYNAPFMSRVTISKDNSKNQVSFKLSSVTAADTAVYYCANHRDWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDINKYIDWYQHKPGKAPKLLIHYASTLQPGVPSRFSGSGSGRDYTFTISSLQPEDIATYYCLQYDDLWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0382", + "inn": "Ontamalimab", + "target": "MADCAM1", + "target_uniprot": "Q13477", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5734", + "product_url": "https://ichor.bio/ontamalimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGINWVRQAPGQGLEWMGWISVYSGNTNYAQKVQGRVTMTADTSTSTAYMDLRSLRSDDTAVYYCAREGSSSSGDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLHTDGTTYLYWYLQKPGQPPQLLIYEVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGIYYCMQNIQLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.1, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0383", + "inn": "Ontuxizumab", + "target": "CD248", + "target_uniprot": "Q9HCU0", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5736", + "product_url": "https://ichor.bio/ontuxizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVRPSQTLSLTCTASGYTFTDYVIHWVKQPPGRGLEWIGYINPYDDDTTYNQKFKGRVTMLVDTSSNTAYLRLSSVTAEDTAVYYCARRGNSYDGYFDYSMDYWGSGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGFFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQNVGTAVAWLQQTPGKAPKLLIYSASNRYTGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQYTNYPMYTFGQGTKVQIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0384", + "inn": "Opicinumab", + "target": "LINGO1", + "target_uniprot": "Q96FE5", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5738", + "product_url": "https://ichor.bio/opicinumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSAYEMKWVRQAPGKGLEWVSVIGPSGGFTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATEGDNDAFDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSAYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.11, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0385", + "inn": "Orilanolimab", + "target": "FCGRT", + "target_uniprot": "P55899", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5744", + "product_url": "https://ichor.bio/orilanolimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAELKKPGASVKLSCKASGYTFTSYGISWVKQATGQGLEWIGEIYPRSGNTYYNEKFKGRATLTADKSTSTAYMELRSLRSEDSAVYFCARSTTVRPPGIWGTGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASDHINNWLAWYQQKPGQAPRLLISGATSLETGVPSRFSGSGTGKDYTLTISSLQPEDFATYYCQQYWSTPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0386", + "inn": "Orticumab", + "target": "oxLDL", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5746", + "product_url": "https://ichor.bio/orticumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVSSISVGGHRTYYADSVKGRSTISRDNSKNTLYLQMNSLRAEDTAVYYCARIRVGPSGGAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSNTNIGKNYVSWYQQLPGTAPKLLIYANSNRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCASWDASLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.6, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0387", + "inn": "Osocimab", + "target": "F11", + "target_uniprot": "P03951", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5747", + "product_url": "https://ichor.bio/osocimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSQYGMDWVRQAPGKGLEWVSGIGPSGGSTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGGPYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQADSFPVTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.84, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0388", + "inn": "Otilimab", + "target": "CSF2", + "target_uniprot": "P04141", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5748", + "product_url": "https://ichor.bio/otilimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMNWVRQAPGKGLEWVSGIENKYAGGATYYAASVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGFGTDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIELTQPPSVSVAPGQTARISCSGDSIGKKYAYWYQQKPGQAPVLVIYKKRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCSAWGDKGMVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0389", + "inn": "Pacmilimab", + "target": "PD-L1", + "target_uniprot": "Q9NZQ7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5752", + "product_url": "https://ichor.bio/pacmilimab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSSIWRNGIVTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKWSAAFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "QGQSGSGIALCPSHFCQLPQTGGGSSGGSGGSGGISSGLLSGRSDNHGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQDNGYPSTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 152.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0390", + "inn": "Pamrevlumab", + "target": "CTGF", + "target_uniprot": "P29279", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5754", + "product_url": "https://ichor.bio/pamrevlumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EGQLVQSGGGLVHPGGSLRLSCAGSGFTFSSYGMHWVRQAPGKGLEWVSGIGTGGGTYSTDSVKGRFTISRDNAKNSLYLQMNSLRAEDMAVYYCARGDYYGSGSFFDCWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0391", + "inn": "Pateclizumab", + "target": "LTA", + "target_uniprot": "P01374", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5757", + "product_url": "https://ichor.bio/pateclizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYVIHWVRQAPGKGLEWVGYNNPYNAGTNYNEKFKGRFTISSDKSKNTAYLQMNSLRAEDTAVYYCSRPTMLPWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQAVSSAVAWYQQKPGKAPKLLIYSASHRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQESYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0392", + "inn": "Pepinemab", + "target": "SEMA4D", + "target_uniprot": "Q92854", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5768", + "product_url": "https://ichor.bio/pepinemab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYSFSDYYMHWVRQAPGQGLEWMGQINPTTGGASYNQKFKGKATITVDKSTSTAYMELSSLRSEDTAVYYCARYYYGRHFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSNEDPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0393", + "inn": "Perakizumab", + "target": "IL17A", + "target_uniprot": "Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5769", + "product_url": "https://ichor.bio/perakizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYTMLWVRQAPGKGLEWVAIIKSGGSYSYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDGDYGSSYGAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDINSYLSWFQQKPGKAPKSLIVRANRLVDGVPSRFSGSGSGQDYSLTISSLQPEDFATYYCLQYDAFPPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0394", + "inn": "Pidilizumab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5773", + "product_url": "https://ichor.bio/pidilizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGSELKKPGASVKISCKASGYTFTNYGMNWVRQAPGQGLQWMGWINTDSGESTYAEEFKGRFVFSLDTSVNTAYLQITSLTAEDTGMYFCVRVGYDALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPSSLSASVGDRVTITCSARSSVSYMHWFQQKPGKAPKLWIYRTSNLASGVPSRFSGSGSGTSYCLTINSLQPEDFATYYCQQRSSFPLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0395", + "inn": "Plozalizumab", + "target": "CCR2", + "target_uniprot": "P41597", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5778", + "product_url": "https://ichor.bio/plozalizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSAYAMNWVRQAPGKGLEWVGRIRTKNNNYATYYADSVKDRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTFYGNGVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSLLDSDGKTFLNWFQQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPYTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0396", + "inn": "Porgaviximab", + "target": "Zaire Ebola virus", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5780", + "product_url": "https://ichor.bio/porgaviximab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGGGLMQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFTISRDDSKRSVYLQMNTLRAEDTGIYYCTRGNGNYRAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPASLSVSVGETVSITCRASENIYSSLAWYQQKQGKSPQLLVYSATILADGVPSRFSGSGSGTQYSLKINSLQSEDFGTYYCQHFWGTPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0397", + "inn": "Praluzatamab", + "target": "ALCAM", + "target_uniprot": "Q13740", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5785", + "product_url": "https://ichor.bio/praluzatamab-biosimilar-research-grade-ich5785", + "rrid": "", + "sequences": { + "heavy_chain": "QITLKESGPTLVKPTQTLTLTCTFSGFSLSTYGMGVGWIRQPPGKALEWLANIWWSEDKHYSPSLKSRLTITKDTSKNQVVLTITNVDPVDTATYYCVQIDYGNDYAFTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QGQSGQGLCHPAVLSAWESCSSGGGSSGGSAVGLLAPPGGLSGRSDNHGGSDIVMTQSPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 156.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.17, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0398", + "inn": "Praluzatamab Ravtansine", + "target": "ALCAM / CD166", + "target_uniprot": "Q13740", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5785R", + "product_url": "https://ichor.bio/praluzatamab-ravtansine-biosimilar-research-grade-ich5785r", + "rrid": "", + "sequences": { + "heavy_chain": "QITLKESGPTLVKPTQTLTLTCTFSGFSLSTYGMGVGWIRQPPGKALEWLANIWWSEDKHYSPSLKSRLTITKDTSKNQVVLTITNVDPVDTATYYCVQIDYGNDYAFTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QGQSGQGLCHPAVLSAWESCSSGGGSSGGSAVGLLAPPGGLSGRSDNHGGSDIVMTQSPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 156.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.17, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0399", + "inn": "Prasinezumab", + "target": "SNCA", + "target_uniprot": "P37840", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5786", + "product_url": "https://ichor.bio/prasinezumab-biosimilar-research-grade-ich5786", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASISSGGGSTYYPDNVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARGGAGIDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKSIQTLLYSSNQKNYLAWFQQKPGKAPKLLIYWASIRKSGVPSRFSGSGSGTDFTLTISSLQPEDLATYYCQQYYSYPLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.5, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0400", + "inn": "Pritoxaximab", + "target": "shiga toxin type 1", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5789", + "product_url": "https://ichor.bio/pritoxaximab-biosimilar-research-grade-ich5789", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGAELVRSGASVRMSCKASGYTFTSYNMHWVKQTPGQGLEWIGYIYPGNGGTNYIQKFKGKAILTADTSSSTAYMQISSLTSEDSAVYFCTRSPSHYSSDPYFDYWGQGTTLTVSSEFASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMSQSHKFMSTSVGDRVSITCKASQDVGTAVAWYQQNPGQSPKFLIYWASTRHTGVPDRFTGSGSGTDFTLTITNVQSEDLADYFCQQYSSYPLTFGAGTSLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.17, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0401", + "inn": "Prolgolimab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - Vlambda-Ckappa", + "product_sku": "ICH5791", + "product_url": "https://ichor.bio/prolgolimab-biosimilar-research-grade-ich5791", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGGGLVQPGGSLRLSCAASGFTFSSYWMYWVRQVPGKGLEWVSAIDTGGGRTYYADSVKGRFAISRVNAKNTMYLQMNSLRAEDTAVYYCARDEGGGTGWGVLKDWPYGLDAWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QPVLTQPLSVSVALGQTARITCGGNNIGSKNVHWYQQKPGQAPVLVIYRDSNRPSGIPERFSGSNSGNTATLTISRAQAGDEADYYCQVWDSSTAVFGTGTKLTVLQRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0402", + "inn": "Quavonlimab", + "target": "CTLA4", + "target_uniprot": "P16410", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5794", + "product_url": "https://ichor.bio/quavonlimab-biosimilar-research-grade-ich5794", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDNWMNWVRQAPGKGLEWLAQIRNKPYNYETYYSASVKGRFTISRDDSKNSVYLQMNSLKTEDTGVYYCTAQFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSENIYGGLNWYQRKPGKSPKLLIYGATNLASGVSSRFSGSGSGTDYTLTISSLQPEDVATYYCQNVLRSPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0403", + "inn": "Quetmolimab", + "target": "CX3CL1", + "target_uniprot": "P78423", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5795", + "product_url": "https://ichor.bio/quetmolimab-biosimilar-research-grade-ich5795", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYIHWVKQAPGQGLEWIGWIYPGDGSPKFNERFKGRTTLTADKSTNTAYMLLSSLRSEDTAVYFCATGPTDGDYFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPAAAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASGNIHNFLAWYQQKPGKAPKLLIYNEKTLADGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQFWSTPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0404", + "inn": "Quilizumab", + "target": "IGHE", + "target_uniprot": "P01854", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5796", + "product_url": "https://ichor.bio/quilizumab-biosimilar-research-grade-ich5796", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYGIAWVRQAPGKGLEWVAFISDLAYTIYYADTVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDNWDAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLVHNNANTYLHWYQQKPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCSQNTLVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0405", + "inn": "Racotumomab", + "target": "idiotope of anti-", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5797", + "product_url": "https://ichor.bio/racotumomab-biosimilar-research-grade-ich5797", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQSGAELVKPGASVKLSCKASGYTFTSYDINWVRQRPEQGLEWIGWIFPGDGSTKYNEKFKGKATLTTDKSSSTAYMQLSRLTSEDSAVYFCAREDYYDNSYYFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", + "light_chain": "DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.35, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0406", + "inn": "Rafivirumab", + "target": "RABV", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5799", + "product_url": "https://ichor.bio/rafivirumab-biosimilar-research-grade-ich5799", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFNRYTVNWVRQAPGQGLEWMGGIIPIFGTANYAQRFQGRLTITADESTSTAYMELSSLRSDDTAVYFCARENLDNSGTYYYFSGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "QSALTQPRSVSGSPGQSVTISCTGTSSDIGGYNFVSWYQQHPGKAPKLMIYDATKRPSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCCSYAGDYTPGVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.88, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0407", + "inn": "Ralpancizumab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5801", + "product_url": "https://ichor.bio/ralpancizumab-biosimilar-research-grade-ich5801", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGEIHPSGGRTNYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARERPLYASDLWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVHTAVAWYQQKPGKAPKLLIYHASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQRYSLWRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0408", + "inn": "Ranevetmab", + "target": "NGF", + "target_uniprot": "P01138", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5805", + "product_url": "https://ichor.bio/ranevetmab-biosimilar-research-grade-ich5805", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCVASGFSLTNNNVNWVRQAPGKGLEWVGGVWAGGATDYNSALKSRFTISRDNAKNTVFLQMHSLRSEDTAVYYCARDGGYSSSTLYAMDAWGQGTSVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKPVFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK", + "light_chain": "DIVMTQSPASLSLSQGETVTITCRASEDIYNALAWYQQKPGQAPKLLIYNTDTLHTGVPSRFSGSGSGTDFSLTISSLEPEDVAVYYCQHYFHYPRTFGQGTKVELKRNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 5.79, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0409", + "inn": "Ravagalimab", + "target": "CD40", + "target_uniprot": "P25942", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5806", + "product_url": "https://ichor.bio/ravagalimab-biosimilar-research-grade-ich5806", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSDYGMNWVRQAPGKGLEWIAYISSGRGNIYYADTVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARSWGYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDQLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSLLNRGNQKNYLTWFQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYTYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0410", + "inn": "Refanezumab", + "target": "MAG", + "target_uniprot": "P20916", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5810", + "product_url": "https://ichor.bio/refanezumab-biosimilar-research-grade-ich5810", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGSELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGEPTYADDFTGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPINYYGINYEGYVMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSHSVLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCHQYLSSLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 148.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0411", + "inn": "Relfovetmab", + "target": "Felcat NGF", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5814", + "product_url": "https://ichor.bio/relfovetmab-biosimilar-research-grade-ich5814", + "rrid": "", + "sequences": { + "heavy_chain": "DVQLVESGGDLVKPGGSLRLTCVASGFTYSNYWMHWVRQAPGKGLQWVARIDPYGGGTKHNEKFKRRFTISRDNAKNTLYLQMNSLKTEDTATYYCVRSGYDYYFDVWGQGTLVTVSSASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", + "light_chain": "EIQMTQSPSSLSASPGDRVTITCRASENIYSFLAWYQQKPGKVPKLLIYNANTLAEGVPSRFSGSGSGTDFTLTISSLEPEDAATYYCQHHFGTPFTFGSGTKLEIKRSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFQRSECQRE", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 148.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.22, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0412", + "inn": "Revdofilimab", + "target": "TNFRSF4", + "target_uniprot": "P43489", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5818", + "product_url": "https://ichor.bio/revdofilimab-biosimilar-research-grade-ich5818", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYGMSWVRQAPGKGLELVATINSNGGRTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGITTAYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKASQSVDYDGDSYMHWYQQKPGQPPKLLIYAASILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSNEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.87, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0413", + "inn": "Rinucumab", + "target": "PDGFRB", + "target_uniprot": "P09619", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5825", + "product_url": "https://ichor.bio/rinucumab-biosimilar-research-grade-ich5825", + "rrid": "", + "sequences": { + "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSITSSSYYWGWIRQPPGKGLEWIGSIYYRGSTNYNPSLKSRVTISVDSSKNQFYLKVSSVTAVDTAVYYCARQNGAARPSWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPDTISLSPGERATLSCRASQSISSIYLAWYQQKPGQAPRLLIYGASSRVTGIPDRFSVSGSGTDFTLTISRLEPEDFAVYYCQHYGISPFTFGPGTKVDIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0414", + "inn": "Ripertamab", + "target": "MS4A1", + "target_uniprot": "P11836", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5826", + "product_url": "https://ichor.bio/ripertamab-biosimilar-research-grade-ich5826", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.57, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0415", + "inn": "Rivabazumab", + "target": "PcrV protein type III secretion system", + "target_uniprot": null, + "format": "Fab fragment (1 H-fragment + 1 L)", + "isotype": "Fab' - G1 - kappa", + "product_sku": "ICH5827", + "product_url": "https://ichor.bio/rivabazumab-biosimilar-research-grade-ich5827", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCAASGFTFSNYPMHWVRQAPGKGLEWVAVISYDGSEKWYADSVKGRFTISRDNSKNTLYLEMNSLRPEDTAVYYCARNRGDIYYDFTYAMDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSSDKTHTCPPCPAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSTLSASVGDSVTITCRASEGVDRWLAWYQQKPGRAPKLLIYDASTLQSGVPSRFSGSGSGTEFSLTISSLQPDDVATYYCQHFWGTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGES", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 49.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.14, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0416", + "inn": "Roledumab", + "target": "RHD", + "target_uniprot": "Q02161", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5830", + "product_url": "https://ichor.bio/roledumab-biosimilar-research-grade-ich5830", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCTASGFTFKNYAMHWVRQAPAKGLEWVATISYDGRNIQYADSVKGRFTFSRDNSQDTLYLQLNSLRPEDTAVYYCARPVRSRWLQLGLEDAFHIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "AIRMTQSPSSFSASTGDRVTITCRASQDIRNYVAWYQQKSGKAPKFLIYAASTLQSGVPSRFSGSGSGTDFTLTINSLQSEDFATYYCQQYYNSPPTFGQGTRVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0417", + "inn": "Rontalizumab", + "target": "IFNA1", + "target_uniprot": "P0DY56", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5835", + "product_url": "https://ichor.bio/rontalizumab-biosimilar-research-grade-ich5835", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCATSGYTFTEYIIHWVRQAPGKGLEWVASINPDYDITNYNQRFKGRFTISLDKSKRTAYLQMNSLRAEDTAVYYCASWISDFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKVLISYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWGIPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0418", + "inn": "Rosmantuzumab", + "target": "RSPO3", + "target_uniprot": "Q9BXY4", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5836", + "product_url": "https://ichor.bio/rosmantuzumab-biosimilar-research-grade-ich5836", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYSIHWVRQAPGQGLEWIGYIYPSNGDSGYNQKFKNRVTMTRDTSTSTAYMELSRLRSEDTAVYYCATYFANNFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQSVDYDGDSYMNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISPVQAEDFATYYCQQSNEDPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0419", + "inn": "Samrotamab", + "target": "LRRC15", + "target_uniprot": "Q8TF66", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5846", + "product_url": "https://ichor.bio/samrotamab-biosimilar-research-grade-ich5846", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYKFSSYWIEWVKQAPGQGLEWIGEILPGSDTTNYNEKFKDRATFTSDTSINTAYMELSRLRSDDTAVYYCARDRGNYRAWFGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGGAVKFLIYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQGEALPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0420", + "inn": "Sasanlimab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5848", + "product_url": "https://ichor.bio/sasanlimab-biosimilar-research-grade-ich5848", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWINWVRQAPGQGLEWMGNIYPGSSLTNYNEKFKNRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARLSTGTFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSLWDSGNQKNFLTWYQQKPGQPPKLLIYWTSYRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYFYPHTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0421", + "inn": "Semorinemab", + "target": "MAPT", + "target_uniprot": "P10636", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5850", + "product_url": "https://ichor.bio/semorinemab-biosimilar-research-grade-ich5850", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGLIFRSYGMSWVRQAPGKGLEWVATINSGGTYTYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCANSYSGAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DDVLTQTPLSLPVTPGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSLVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.81, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0422", + "inn": "Serclutamab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5853", + "product_url": "https://ichor.bio/serclutamab-biosimilar-research-grade-ich5853", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQESGPGLVKPSQTLSLTCTVSGYSISRDFAWNWIRQPPGKGLEWMGYISYNGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTASRGFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSMSVSVGDRVTITCHSSQDINSNIGWLQQKPGKSFKGLIYHGTNLDDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCVQYAQFPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.31, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0423", + "inn": "Seribantumab", + "target": "ERBB3", + "target_uniprot": "P21860", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5854", + "product_url": "https://ichor.bio/seribantumab-biosimilar-research-grade-ich5854", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYVMAWVRQAPGKGLEWVSSISSSGGWTLYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGLKMATIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGSYNVVSWYQQHPGKAPKLIIYEVSQRPSGVSNRFSGSKSGNTASLTISGLQTEDEADYYCCSYAGSSIFVIFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.17, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0424", + "inn": "Serplulimab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5855", + "product_url": "https://ichor.bio/serplulimab-biosimilar-research-grade-ich5855", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGLVKPGGSLRLSCAASGFTFSNYGMSWIRQAPGKGLEWVSTISGGGSNIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCVSYYYGIDFWGQGTSVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVTTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHYTIPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0425", + "inn": "Setoxaximab", + "target": "shiga toxin type 2", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5856", + "product_url": "https://ichor.bio/setoxaximab-biosimilar-research-grade-ich5856", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQQPGPELEKPGASVKLSCKASGYSFTDYNMNWVKQNNGESLEWIGKIDPYYGGPSYNQKFKDKATLTVDKSSSTAYMQLKSLTSEDSAVYYCTRGGNRDWYFDVWGAGTTLTVSAEFASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVLSQSPSSLVVSVGEKVTMSCKSSQSLLYSRNQKNYLAWYQQKPGQSPKVLIYWASTRESGVPDRLTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.04, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0426", + "inn": "Setrusumab", + "target": "SOST", + "target_uniprot": "Q9BQB4", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5857", + "product_url": "https://ichor.bio/setrusumab-biosimilar-research-grade-ich5857", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFRSHWLSWVRQAPGKGLEWVSNINYDGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDTYLHFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIALTQPASVSGSPGQSITISCTGTSSDVGDINDVSWYQQHPGKAPKLMIYDVNNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCQSYAGSYLSEVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.69, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0427", + "inn": "Sirtratumab", + "target": "SLITRK6", + "target_uniprot": "Q9H5Y7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5868", + "product_url": "https://ichor.bio/sirtratumab-biosimilar-research-grade-ich5868", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNQYYADSVKGRFTISRDNSKNTLFLQMHSLRAEDTAVYYCARGLTSGRYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLLSHGFNYLDWYLQKPGQSPQLLIYLGSSRASGVPDRFSGSGSGTDFTLKISRVEAEDVGLYYCMQPLQIPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0428", + "inn": "Sirtratumab Vedotin", + "target": "SLITRK6", + "target_uniprot": "Q9H5Y7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5868V", + "product_url": "https://ichor.bio/sirtratumab-vedotin-biosimilar-research-grade-ich5868v", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNQYYADSVKGRFTISRDNSKNTLFLQMHSLRAEDTAVYYCARGLTSGRYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLLSHGFNYLDWYLQKPGQSPQLLIYLGSSRASGVPDRFSGSGSGTDFTLKISRVEAEDVGLYYCMQPLQIPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0429", + "inn": "Sirukumab", + "target": "IL6", + "target_uniprot": "P05231", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5869", + "product_url": "https://ichor.bio/sirukumab-biosimilar-research-grade-ich5869", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSPFAMSWVRQAPGKGLEWVAKISPGGSWTYYSDTVTGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLWGYYALDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCSASISVSYMYWYQQKPGQAPRLLIYDMSNLASGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCMQWSGYPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0430", + "inn": "Solanezumab", + "target": "APP", + "target_uniprot": "P05067", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5871", + "product_url": "https://ichor.bio/solanezumab-biosimilar-research-grade-ich5871", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYSMSWVRQAPGKGLELVAQINSVGNSTYYPDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCASGDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLIYSDGNAYLHWFLQKPGQSPRLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.33, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0431", + "inn": "Spartalizumab", + "target": "PDCD1", + "target_uniprot": "Q15116", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5881", + "product_url": "https://ichor.bio/spartalizumab-biosimilar-research-grade-ich5881", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLRISCKGSGYTFTTYWMHWVRQATGQGLEWMGNIYPGTGGSNFDEKFKNRVTITADKSTSTAYMELSSLRSEDTAVYYCTRWTTGTGAYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCKSSQSLLDSGNQKNFLTWYQQKPGQAPRLLIYWASTRESGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCQNDYSYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.59, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0432", + "inn": "Spesolimab", + "target": "IL1RL2", + "target_uniprot": "Q9HB29", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5882", + "product_url": "https://ichor.bio/spesolimab-biosimilar-research-grade-ich5882", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYSFTSSWIHWVKQAPGQGLEWMGEINPGNVRTNYNENFRNKVTMTVDTSISTAYMELSRLRSDDTAVYYCTVVFYGEPYFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QIVLTQSPGTLSLSPGERATMTCTASSSVSSSYFHWYQQKPGQAPRLWIYRTSRLASGVPDRFSGSGSGTDFTLTISRLEPEDAATYYCHQFHRSPLTFGAGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0433", + "inn": "Suptavumab", + "target": "RSV", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5887", + "product_url": "https://ichor.bio/suptavumab-biosimilar-research-grade-ich5887", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGDLVQPGRSLRLSCVASGFTFDDYAMHWVRQAPGKGLEWVSGVSWSGSTVGYADSVKGRFTVSRDNAQKSLYLQMNSLRAEDTALYYCVKDAYKFNYYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQTILSNLAWYLQKPGQAPRLLIYGASTRATGLPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0434", + "inn": "Suvizumab", + "target": "HIV-1", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5890", + "product_url": "https://ichor.bio/suvizumab-biosimilar-research-grade-ich5890", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQRPDSLSASVGDRVTMSCKSSQSLLNSGDQKNYLTWYQQKPGQPPKLLIYWASTGESGVPDRFSGSGSGTDFTFTISSLQPEDIATYYCQNDYSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0435", + "inn": "Suvratoxumab", + "target": "alpha toxin", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5891", + "product_url": "https://ichor.bio/suvratoxumab-biosimilar-research-grade-ich5891", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSHDMHWVRQATGKGLEWVSGIGTAGDTYYPDSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARDRYSPTGHYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCKQYADYWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0436", + "inn": "Tabituximab", + "target": "FZD10", + "target_uniprot": "Q9ULW2", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5892", + "product_url": "https://ichor.bio/tabituximab-biosimilar-research-grade-ich5892", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLQQSGAELVKPGASVKLSCTASGFNINDTYMHWVKQRPEQGLEWIGRIDPANGNTKYDPKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCARGARGSRFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPASLSVSVGETVTITCRASENIYSNLAWYQQKQGKSPQLLVYVATNLADGVPSRFSGSGSGTQYSLKINSLQSEDFGSYYCQHFWGTPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0437", + "inn": "Tadocizumab", + "target": "ITGA2B_ITGB3", + "target_uniprot": "P08514;P05106", + "format": "Fab fragment (1 H-fragment + 1 L)", + "isotype": "Fab - G1 - kappa", + "product_sku": "ICH5893", + "product_url": "https://ichor.bio/tadocizumab-biosimilar-research-grade-ich5893", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFTNYLIEWVRQAPGQGLEWIGVIYPGSGGTNYNEKFKGRVTLTVDESTNTAYMELSSLRSEDTAVYFCARRDGNYGWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQTPSTLSASVGDRVTISCRASQDINNYLNWYQQKPGKAPKLLIYYTSTLHSGVPSRFSGSGSGTDYTLTISSLQPDDFATYFCQQGNTLPWTFGQGTKVEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 47.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.5, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0438", + "inn": "Tafolecimab", + "target": "PCSK9", + "target_uniprot": "Q8NBP7", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5894", + "product_url": "https://ichor.bio/tafolecimab-biosimilar-research-grade-ich5894", + "rrid": "", + "sequences": { + "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSISSASYYWSWIRQPPGKGLEWIGSINYRGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARENSGVVPAAGPNWFGPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRRNWFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.05, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0439", + "inn": "Talacotuzumab", + "target": "IL3RA", + "target_uniprot": "P26951", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5896", + "product_url": "https://ichor.bio/talacotuzumab-biosimilar-research-grade-ich5896", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFTDYYMKWARQMPGKGLEWMGDIIPSNGATFYNQKFKGQVTISADKSISTTYLQWSSLKASDTAMYYCARSHLLRASWFAYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKALPAPEEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCESSQSLLNSGNQKNYLTWYQQKPGQPPKPLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0440", + "inn": "Tamrintamab", + "target": "DPEP3", + "target_uniprot": "Q9H4B8", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5898", + "product_url": "https://ichor.bio/tamrintamab-biosimilar-research-grade-ich5898", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYWIEWVRQAPGQGLEWMGEILPGSGNTYYNERFKDRVTITADESTSTAYMELSSLRSEDTAVYYCARRAAAYYSNPEWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "EIVLTQSPATLSLSPGERATLSCTASSSVNSFYLHWYQQKPGLAPRLLIYSTSNLASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCHQYHRSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0441", + "inn": "Tamtuvetmab", + "target": "CD52", + "target_uniprot": "Q28896", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - Vkappa-Clambda", + "product_sku": "ICH5899", + "product_url": "https://ichor.bio/tamtuvetmab-biosimilar-research-grade-ich5899", + "rrid": "", + "sequences": { + "heavy_chain": "EVKLLESGGGLVQPGGSMRLSCAGSGFTFTDFYMNWIRQPAGKAPEWLGFIRDKAKGYTTEYNPSVKGRFTISRDNTQNMLYLQMNTLRAEDTATYYCAREGHTAAPFDYWGQGTLVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQKSLSHSPGK", + "light_chain": "DIKMTQSPSFLSASVGDRVTLNCKASQNIDKYLNWYQQKLGESPKLLIYNTNNLQTGIPSRFSGSGSGTDFTLTISSLQPEDVATYFCLQHISRPRTFGGGTHLTVLGQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.35, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0442", + "inn": "Tarextumab", + "target": "NOTCH2", + "target_uniprot": "Q04721", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5902", + "product_url": "https://ichor.bio/tarextumab-biosimilar-research-grade-ich5902", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSGMSWVRQAPGKGLEWVSVIASSGSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSIFYTTWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVLTQSPATLSLSPGERATLSCRASQSVRSNYLAWYQQKPGQAPRLLIYGASSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNFPITFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.05, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0443", + "inn": "Tavolimab", + "target": "TNFRSF4", + "target_uniprot": "P43489", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5903", + "product_url": "https://ichor.bio/tavolimab-biosimilar-research-grade-ich5903", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCAVYGGSFSSGYWNWIRKHPGKGLEYIGYISYNGITYHNPSLKSRITINRDTSKNQYSLQLNSVTPEDTAVYYCARYKYDYDGGHAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGSALPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.4, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0444", + "inn": "Telazorlimab", + "target": "TNFRSF4", + "target_uniprot": "P43489", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5909", + "product_url": "https://ichor.bio/telazorlimab-biosimilar-research-grade-ich5909", + "rrid": "", + "sequences": { + "heavy_chain": "QVTLKESGPALVKPTQTLTLTCSFSGFSLSTSGMGVGWIRQPPGKALEWIAHIWWDDDKYYNTALKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARIDWDGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASSSVSYMHWYQQKPGQAPRPWIYATSNRATGIPARFSGSGSGTDYTLTISSLEPEDFAVYYCQQWSSNPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.07, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0445", + "inn": "Temelimab", + "target": "endogenous retrovirus", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5912", + "product_url": "https://ichor.bio/temelimab-biosimilar-research-grade-ich5912", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDYEMHWVRQAPGQGLEWIGAVAPETGGTAYNQKFKGRATITADKSTSTAYMELSSLRSEDTAVYYCTSTVVPFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "QIQLTQSPSSLSASVGDRVTITCSASSSVSYMYWYQQKPGKAPKAWIYRTSNLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYQSLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0446", + "inn": "Tenatumomab", + "target": "TNC", + "target_uniprot": "P24821", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2b - kappa", + "product_sku": "ICH5914", + "product_url": "https://ichor.bio/tenatumomab-biosimilar-research-grade-ich5914", + "rrid": "", + "sequences": { + "heavy_chain": "EIQLQQSGPELVKPGASVKVSCKASGYAFTSYNMYWVKQSHGKSLEWIGYIDPYNGVTSYNQKFKGKATLTVDKSSSTAYMHLNSLTSEDSAVYYCARGGGSIYYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", + "light_chain": "DIVMTQAAPSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLRISRVEAEDVGVYYCMQHLEYPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0447", + "inn": "Tesidolumab", + "target": "C5", + "target_uniprot": "P01031", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5918", + "product_url": "https://ichor.bio/tesidolumab-biosimilar-research-grade-ich5918", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIGPFFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARDTPYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "SYELTQPLSVSVALGQTARITCSGDSIPNYYVYWYQQKPGQAPVLVIYDDSNRPSGIPERFSGSNSGNTATLTISRAQAGDEADYYCQSFDSSLNAEVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.84, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0448", + "inn": "Tesnatilimab", + "target": "KLRK1", + "target_uniprot": "P26718", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5919", + "product_url": "https://ichor.bio/tesnatilimab-biosimilar-research-grade-ich5919", + "rrid": "", + "sequences": { + "heavy_chain": "QVHLQESGPGLVKPSETLSLTCTVSDDSISSYYWSWIRQPPGKGLEWIGHISYSGSANYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCANWDDAFNIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.63, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0449", + "inn": "Tifcemalimab", + "target": "BTLA", + "target_uniprot": "Q7Z6A9", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5920", + "product_url": "https://ichor.bio/tifcemalimab-biosimilar-research-grade-ich5920", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKLSCKASGYNFKHTYAHWVRQAPGQGLEWIGRIDPANGNTKYDPKFQGRATMTADTASNTAYLELSSLRSEDTAVYYCVADHYGSSLLDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DVVMTQTPLSLSVTPGQPASISCKSSQSLLDSDGKTYLNWFQQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTYFPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0450", + "inn": "Tigatuzumab", + "target": "TNFRSF10B", + "target_uniprot": "O14763", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5921", + "product_url": "https://ichor.bio/tigatuzumab-biosimilar-research-grade-ich5921", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARRGDSMITTDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSYRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0451", + "inn": "Tilogotamab", + "target": "TNFRSF10B", + "target_uniprot": "O14763", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5922", + "product_url": "https://ichor.bio/tilogotamab-biosimilar-research-grade-ich5922", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGFNIKDTHMHWVRQAPGQRLEWIGRIDPANGNTEYDQKFQGRVTITVDTSASTAYMELSSLRSEDTAVYYCARWGTNVYFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHGALHNHYTQKSLSLSPG", + "light_chain": "DIQLTQSPSSLSASVGDRVTITCSASSSVSYMYWYQQKPGKAPKPWIYRTSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYHSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0452", + "inn": "Timigutuzumab", + "target": "ERBB2", + "target_uniprot": "P04626", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5925", + "product_url": "https://ichor.bio/timigutuzumab-biosimilar-research-grade-ich5925", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.32, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0453", + "inn": "Timolumab", + "target": "AOC3", + "target_uniprot": "Q16853", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5926", + "product_url": "https://ichor.bio/timolumab-biosimilar-research-grade-ich5926", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFFSYAMHWVRQTPGKGLEWVAVIWFDGSNENYVDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDAWSYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "VIQLTQSPSSLSASVGDRVTITCRASQGISRALAWYQQKPGKGPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0454", + "inn": "Tomaralimab", + "target": "TLR2", + "target_uniprot": "O60603", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5932", + "product_url": "https://ichor.bio/tomaralimab-biosimilar-research-grade-ich5932", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGSELKKPGASVKLSCKASGFTFTTYGINWVRQAPGQGLEWIGWIYPRDGSTNFNENFKDRATITVDTSASTAYMELSSLRSEDTAVYFCARLTGGTFLDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIVLTQSPATLSLSPGERATLSCRASESVEYYGTSLMQWYQQKPGQPPKLLIFGASNVESGVPDRFSGSGSGTDFTLKISRVEAEDVGMYFCQQSRKLPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.56, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0455", + "inn": "Tomuzotuximab", + "target": "EGFR", + "target_uniprot": "P00533", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5933", + "product_url": "https://ichor.bio/tomuzotuximab-biosimilar-research-grade-ich5933", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSTASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPG", + "light_chain": "DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.9, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0456", + "inn": "Tosatoxumab", + "target": "alpha toxin", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda", + "product_sku": "ICH5936", + "product_url": "https://ichor.bio/tosatoxumab-biosimilar-research-grade-ich5936", + "rrid": "", + "sequences": { + "heavy_chain": "EVQMVQSGAEVKKPGEPLKISCKGSGYKFGTHWIGWVRQRPGKGLEWMGIIHPADSETKYSPSFQGQVSFSADKSSNTAYLHWSTLRASDTAMYYCARRSGSSSWYALDFWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "QSVLTQSPSASGTPGQRVTISCSGGSSNIGSNTVNWYQQFPGAAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGLYVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.51, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0457", + "inn": "Tregalizumab", + "target": "CD4", + "target_uniprot": "P01730", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5942", + "product_url": "https://ichor.bio/tregalizumab-biosimilar-research-grade-ich5942", + "rrid": "", + "sequences": { + "heavy_chain": "EEQLVESGGGLVKPGGSLRLSCAASGFSFSDCRMYWLRQAPGKGLEWIGVISVKSENYGANYAESVRGRFTISRDDSKNTVYLQMNSLKTEDTAVYYCSASYYRYDVGAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSYIYWYQQKPGQPPKLLIYLASILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRELPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.66, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0458", + "inn": "Trevogrumab", + "target": "MSTN", + "target_uniprot": "O14793", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5943", + "product_url": "https://ichor.bio/trevogrumab-biosimilar-research-grade-ich5943", + "rrid": "", + "sequences": { + "heavy_chain": "EVQVLESGGDLVQPGGSLRLSCAASGFTFSAYAMTWVRQAPGKGLEWVSAISGSGGSAYYADSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAKDGAWKMSGLDVWGQGTTVIVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DIQMTQSPASLSASVGDRVTITCRASQDISDYLAWYQQKPGKIPRLLIYTTSTLQSGVPSRFRGSGSGTDFTLTISSLQPEDVATYYCQKYDSAPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0459", + "inn": "Ulocuplumab", + "target": "CXCR4", + "target_uniprot": "P61073", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5954", + "product_url": "https://ichor.bio/ulocuplumab-biosimilar-research-grade-ich5954", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAAAGFTFSSYSMNWVRQAPGKGLEWVSYISSRSRTIYYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARDYGGQPPYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFVTYYCQQYNSYPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.37, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0460", + "inn": "Urabrelimab", + "target": "CD47", + "target_uniprot": "Q08722", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5961", + "product_url": "https://ichor.bio/urabrelimab-biosimilar-research-grade-ich5961", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSGTLSLTCAVSGVSIRSINWWNWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLNSVTAADTAVYYCARDGGIAVTDYYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "EIVLTQSPATLSLSPGERATLSCRASESVSSNLAWYQQKPGQAPRLLIYGAFNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSDWFTFGGGTKVEIKTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.09, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0461", + "inn": "Vadastuximab", + "target": "CD33", + "target_uniprot": "P20138", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5964", + "product_url": "https://ichor.bio/vadastuximab-biosimilar-research-grade-ich5964", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYDINWVRQAPGQGLEWIGWIYPGDGSTKYNEKFKAKATLTADTSTSTAYMELRSLRSDDTAVYYCASGYEDAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTINCKASQDINSYLSWFQQKPGKAPKTLIYRANRLVDGVPSRFSGSGSGQDYTLTISSLQPEDFATYYCLQYDEFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.65, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0462", + "inn": "Vantictumab", + "target": "frizzled family receptor", + "target_uniprot": null, + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - lambda", + "product_sku": "ICH5967", + "product_url": "https://ichor.bio/vantictumab-biosimilar-research-grade-ich5967", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSHYTLSWVRQAPGKGLEWVSVISGDGSYTYYADSVKGRFTISSDNSKNTLYLQMNSLRAEDTAVYYCARNFIKYVFANWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIELTQPPSVSVAPGQTARISCSGDNIGSFYVHWYQQKPGQAPVLVIYDKSNRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCQSYANTLSLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 142.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 6.66, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0463", + "inn": "Varisacumab", + "target": "VEGFA", + "target_uniprot": "P15692", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5969", + "product_url": "https://ichor.bio/varisacumab-biosimilar-research-grade-ich5969", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGFDPEDGETIYAQKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCATGRSMVRGVIIPFNGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIRMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.89, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0464", + "inn": "Vatelizumab", + "target": "ITGA2", + "target_uniprot": "P17301", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH5970", + "product_url": "https://ichor.bio/vatelizumab-biosimilar-research-grade-ich5970", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLTNYGIHWIRQPPGKGLEWLGVIWARGFTNYNSALMSRLTISKDNSKNQVSLKLSSVTAADTAVYYCARANDGVYYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DFVMTQSPAFLSVTPGEKVTITCSAQSSVNYIHWYQQKPDQAPKKLIYDTSKLASGVPSRFSGSGSGTDYTFTISSLEAEDAATYYCQQWTTNPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.1, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0465", + "inn": "Vesencumab", + "target": "NRP1", + "target_uniprot": "O14786", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5977", + "product_url": "https://ichor.bio/vesencumab-biosimilar-research-grade-ich5977", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSQISPAGGYTNYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARGELPYYRMSKVMDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQYFSSYLAWYQQKPGKAPKLLIYGASSRASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLGSPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0466", + "inn": "Vofatamab", + "target": "FGFR3", + "target_uniprot": "P22607", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5986", + "product_url": "https://ichor.bio/vofatamab-biosimilar-research-grade-ich5986", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFTSTGISWVRQAPGKGLEWVGRIYPTSGSTNYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARTYGIYDLYVDYTEYVMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVDTSLAWYKQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGHPQTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0467", + "inn": "Volagidemab", + "target": "GCGR", + "target_uniprot": "P47871", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH5987", + "product_url": "https://ichor.bio/volagidemab-biosimilar-research-grade-ich5987", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVMWYDGSNKDYVDSVKGRFTISRDNSKNTLYLQMNRLRAEDTAVYYCAREKDHYDILTGYNYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSVQPEDFVTYYCLQHNSNPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 147.0, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.04, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0468", + "inn": "Vonlerolizumab", + "target": "TNFRSF4", + "target_uniprot": "P43489", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5989", + "product_url": "https://ichor.bio/vonlerolizumab-biosimilar-research-grade-ich5989", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTDSYMSWVRQAPGQGLEWIGDMYPDNGDSSYNQKFRERVTITRDTSTSTAYLELSSLRSEDTAVYYCVLAPRWYFSVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLRSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGHTLPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.3, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.2, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0469", + "inn": "Vopratelimab", + "target": "ICOS", + "target_uniprot": "Q9Y6W8", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5991", + "product_url": "https://ichor.bio/vopratelimab-biosimilar-research-grade-ich5991", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYWMDWVRQAPGKGLVWVSNIDEDGSITEYSPFVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCTRWGRFGFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSLLSGSFNYLTWYQQKPGQPPKLLIFYASTRHTGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCHHHYNAPPTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.44, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0470", + "inn": "Vorsetuzumab", + "target": "CD70", + "target_uniprot": "P32970", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5992", + "product_url": "https://ichor.bio/vorsetuzumab-biosimilar-research-grade-ich5992", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLKWMGWINTYTGEPTYADAFKGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARDYGDYGMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSREVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0471", + "inn": "Vorsetuzumab Mafodotin", + "target": "TNFSF7 / CD27L / CD70", + "target_uniprot": "P32970", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1", + "product_sku": "ICH5992M", + "product_url": "https://ichor.bio/vorsetuzumab-mafodotin-biosimilar-research-grade-ich5992m", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLKWMGWINTYTGEPTYADAFKGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARDYGDYGMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSREVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.1, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.06, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0472", + "inn": "Vunakizumab", + "target": "IL17A", + "target_uniprot": "Q16552", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5995", + "product_url": "https://ichor.bio/vunakizumab-biosimilar-research-grade-ich5995", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEVHWVRQAPGQGLEWMGVIDPGTGGVAYNQKFEGRVTMTADTSTSTAYMELRSLRSDDTAVYYCTRYSLFYGSSPYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPDFQSVTPKEKVTITCSASSSVNYMHWFQQKPDQSPKLWIYRTSNLASGVPSRFSGSGSGTDYTLTINSLEAEDAATYYCQQRSSYPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.41, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0473", + "inn": "Xentuzumab", + "target": "IGF2", + "target_uniprot": "P01344", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - lambda2", + "product_sku": "ICH5996", + "product_url": "https://ichor.bio/xentuzumab-biosimilar-research-grade-ich5996", + "rrid": "", + "sequences": { + "heavy_chain": "QVELVESGGGLVQPGGSLRLSCAASGFTFTSYWMSWVRQAPGKGLELVSSITSYGSFTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARNMYTHFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVLTQPPSVSGAPGQRVTISCSGSSSNIGSNSVSWYQQLPGTAPKLLIYDNSKRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCQSRDTYGYYWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKGDSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.7, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.21, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0474", + "inn": "Zalifrelimab", + "target": "CTLA4", + "target_uniprot": "P16410", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH5998", + "product_url": "https://ichor.bio/zalifrelimab-biosimilar-research-grade-ich5998", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVGLMGPFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSRYLGWYQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTDFTLTITRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 144.6, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.43, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0475", + "inn": "Zampilimab", + "target": "TGM2", + "target_uniprot": "P21980", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG4 - kappa", + "product_sku": "ICH6001", + "product_url": "https://ichor.bio/zampilimab-biosimilar-research-grade-ich6001", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTLSTHAMSWVRQAPGKGLEWVATISSGGRSTYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARLISTYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", + "light_chain": "DITMTQSPSSLSASVGDRVTITCKASQDINSYLTWFQQKPGKAPKILIYLVNRLVDGVPSRFSGSGSGQDYALTISSLQPEDFATYYCLQYDDFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 143.5, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.39, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0476", + "inn": "Zanidatamab", + "target": "ERBB2", + "target_uniprot": "P04626", + "format": "bispecific / multi-chain (3 chains)", + "isotype": "half-IG G1 - kappa / (scFv - kappa - heavy) -h-CH2-CH3", + "product_sku": "ICH6002", + "product_url": "https://ichor.bio/zanidatamab-biosimilar-research-grade-ich6002", + "rrid": "", + "sequences": { + "heavy_chain": "GEVQLVESGGGLVQPGGSLRLSCAASGFTFADYTMDWVRQAPGKGLEWVGDVNPNSGGSIYNQRFKGRFTFSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYVYPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFALVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "GDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGGSGGGSGGGSGGGSGGGSGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSAAEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYVLPPSRDELTKNQVSLLCLVKGFYPSDIAVEWESNGQPENNYLTWPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 124.8, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.92, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 98.138, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 98.138% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0477", + "inn": "Zelminemab", + "target": "ADCYAP1R1", + "target_uniprot": "P41586", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH6005", + "product_url": "https://ichor.bio/zelminemab-biosimilar-research-grade-ich6005", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVESGAEVVKPGASVKVSCKASGFTFSRFAMHWVRQAPGQGLEWMGVISYDGGNKYYAESVKGRVTMTRDTSTSTLYMELSSLRSEDTAVYYCARGYDVLTGYPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQLTQSPSFLSASVGDRVTITCRASQSIGRSLHWYQQKPGKAPKLLIKYASQSLSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCHQSSRLPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.5, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0478", + "inn": "Ziltivekimab", + "target": "IL6", + "target_uniprot": "P05231", + "format": "standard IgG (2H+2L, theoretical from sequence)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH6008", + "product_url": "https://ichor.bio/ziltivekimab-biosimilar-research-grade-ich6008", + "rrid": "", + "sequences": { + "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTISSNYMIWVRQAPGKGLEWVSDLYYYAGDTYYADSVKGRFTMSRDISKNTVYLQMNSLRAEDTAVYYCARWADDHPPWIDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKVLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQSWLGGSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.4, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.67, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + }, + { + "entry_id": "ICB-BSR-0479", + "inn": "Zenocutuzumab", + "target": null, + "target_uniprot": null, + "format": "bispecific / multi-chain (4 chains)", + "isotype": "IgG1 - kappa", + "product_sku": "ICH6013", + "product_url": "https://ichor.bio/zenocutuzumab-biosimilar-research-grade-ich6013", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKLSCKASGYTFTAYYINWVRQAPGQGLEWIGRIYPGSGYTSYAQKFQGRATLTADESTSTAYMELSSLRSEDTAVYFCARPPVYYDSAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTDPPSREEMTKNQVSLTCEVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", + "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 145.9, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 8.42, + "unit": "pH units", + "method": "theoretical (from sequence)" + }, + { + "parameter": "pct_monomer", + "value": 100.0, + "unit": "%", + "method": "SEC-HPLC (supplier CoA, 100% main peak)" + } + ] + }, + { + "entry_id": "ICB-BSR-0480", + "inn": "Navicixizumab", + "target": "VEGFA + DLL4", + "target_uniprot": "P15692;Q9NR61", + "format": "bispecific / multi-chain (4 chains)", + "isotype": "IgG2 - kappa", + "product_sku": "ICH6020", + "product_url": "https://ichor.bio/navicixizumab-biosimilar-research-grade", + "rrid": "", + "sequences": { + "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWMHWVRQAPGQGLEWMGDINPSNGRTSYKEKFKRRVTLSVDKSSSTAYMELSSLRSEDTAVYFCTIHYDDKYYPLMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREKMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLKSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", + "light_chain": "DIVMTQSPDSLAVSLGERATISCRASESVDNYGISFMKWFQQKPGQPPKLLIYAASNQGSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEVPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", + "source": "IMGT/mAb-DB" + }, + "measurements": [ + { + "parameter": "mw_kda", + "value": 146.2, + "unit": "kDa", + "method": "theoretical (from sequence)" + }, + { + "parameter": "theoretical_pi", + "value": 7.25, + "unit": "pH units", + "method": "theoretical (from sequence)" + } + ] + } + ] +} \ No newline at end of file