{ "dataset": "ichorbio Biosimilar Reference Database", "version": "0.1.3", "antibodies": [ { "entry_id": "ICB-BSR-0001", "inn": "Adalimumab", "target": "TNF alpha", "target_uniprot": "P01375", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4001", "product_url": "https://ichor.bio/adalimumab-biosimilar-research-grade", "rrid": "RRID:AB_2921521", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQRYNRAPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0002", "inn": "Alemtuzumab", "target": "CD52", "target_uniprot": "P31358", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4002", "product_url": "https://ichor.bio/alemtuzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921522", "sequences": { "heavy_chain": "QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQHISRPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.58, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95.802, "unit": "%", "method": "SEC-HPLC (supplier CoA, 95.802% main peak)" } ] }, { "entry_id": "ICB-BSR-0003", "inn": "Bevacizumab", "target": "VEGF", "target_uniprot": "P15692", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH4003", "product_url": "https://ichor.bio/bevacizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921523", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0004", "inn": "Cetuximab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH4004", "product_url": "https://ichor.bio/cetuximab-biosimilar-research-grade-ich4004", "rrid": "RRID:AB_2921524", "sequences": { "heavy_chain": "QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.673, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.673% main peak)" } ] }, { "entry_id": "ICB-BSR-0005", "inn": "Eculizumab", "target": "Complement protein C5", "target_uniprot": "P01031", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2/4 kappa", "product_sku": "ICH4005", "product_url": "https://ichor.bio/eculizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921525", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFSNYWIQWVRQAPGQGLEWMGEILPGSGSTEYTENFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYFFGSSPNWYFDVWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCGASENIYGALNWYQQKPGKAPKLLIYGATNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLNTPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.21, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0006", "inn": "Infliximab", "target": "TNF alpha", "target_uniprot": "P01375", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4006", "product_url": "https://ichor.bio/infliximab-biosimilar-research-grade-ich4006", "rrid": "RRID:AB_2921526", "sequences": { "heavy_chain": "EVKLEESGGGLVQPGGSMKLSCVASGFIFSNHWMNWVRQSPEKGLEWVAEIRSKSINSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYGSTYDYWGQGTTLTVSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DILLTQSPAILSVSPGERVSFSCRASQFVGSSIHWYQQRTNGSPRLLIKYASESMSGIPSRFSGSGSGTDFTLSINTVESEDIADYYCQQSHSWPFTFGSGTNLEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.18, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0007", "inn": "Nimotuzumab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4008", "product_url": "https://ichor.bio/nimotuzumab-biosimilar-research-grade-ich4008", "rrid": "RRID:AB_2921528", "sequences": { "heavy_chain": "QVQLQQSGAEVKKPGSSVKVSCKASGYTFTNYYIYWVRQAPGQGLEWIGGINPTSGGSNFNEKFKTRVTITVDESTNTAYMELSSLRSEDTAFYFCARQGLWFDSDGRGFDFWGQGSTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQNIVHSNGNTYLDWYQQTPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCFQYSHVPWTFGQGTKLQITREVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0008", "inn": "Nivolumab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 kappa", "product_sku": "ICH4009", "product_url": "https://ichor.bio/nivolumab-biosimilar-research-grade-ich4009", "rrid": "RRID:AB_2921529", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.212, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.212% main peak)" } ] }, { "entry_id": "ICB-BSR-0009", "inn": "Omalizumab", "target": "IgE", "target_uniprot": "P01854", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4010", "product_url": "https://ichor.bio/omalizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921530", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNWIRQAPGKGLEWVASITYDGSTNYNPSVKGRITISRDDSKNTFYLQMNSLRAEDTAVYYCARGSHYFGHWHFAVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCRASQSVDYDGDSYMNWYQQKPGKAPKLLIYAASYLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSHEDPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.17, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.868, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.868% main peak)" } ] }, { "entry_id": "ICB-BSR-0010", "inn": "Rituximab", "target": "CD20", "target_uniprot": "P11836", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4011", "product_url": "https://ichor.bio/rituximab-biosimilar-research-grade", "rrid": "RRID:AB_2921531", "sequences": { "heavy_chain": "QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.57, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.782, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.782% main peak)" } ] }, { "entry_id": "ICB-BSR-0011", "inn": "Tocilizumab", "target": "IL-6 receptor", "target_uniprot": "P08887", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4012", "product_url": "https://ichor.bio/tocilizumab-biosimilar-research-grade-ich4012", "rrid": "RRID:AB_2921532", "sequences": { "heavy_chain": "QVQLQESGPGLVRPSQTLSLTCTVSGYSITSDHAWSWVRQPPGRGLEWIGYISYSGITTYNPSLKSRVTMLRDTSKNQFSLRLSSVTAADTAVYYCARSLARTTAMDYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISSYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQGNTLPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.59, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.136, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.136% main peak)" } ] }, { "entry_id": "ICB-BSR-0012", "inn": "Trastuzumab", "target": "HER2", "target_uniprot": "P04626", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4013", "product_url": "https://ichor.bio/trastuzumab-biosimilar-research-grade-ich4013", "rrid": "RRID:AB_2921533", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, ≥95% spec)" } ] }, { "entry_id": "ICB-BSR-0013", "inn": "Trastuzumab Deruxtecan", "target": "ERBB2 / HER2 / CD340", "target_uniprot": "P04626", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH4013D", "product_url": "https://ichor.bio/trastuzumab-deruxtecan-biosimilar-research-grade-ich4013d", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0014", "inn": "Alirocumab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH4016", "product_url": "https://ichor.bio/alirocumab-biosimilar-research-grade", "rrid": "RRID:AB_2921534", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFNNYAMNWVRQAPGKGLDWVSTISGSGGTTNYADSVKGRFIISRDSSKHTLYLQMNSLRAEDTAVYYCAKDSNWGNFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLYRSNNRNFLGWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYTTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0015", "inn": "Avelumab", "target": "PD-L1", "target_uniprot": "Q9NZQ7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 lambda", "product_sku": "ICH4017", "product_url": "https://ichor.bio/avelumab-biosimilar-research-grade", "rrid": "RRID:AB_2921535", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYIMMWVRQAPGKGLEWVSSIYPSGGITFYADTVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARIKLGTVTTVDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.014, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.014% main peak)" } ] }, { "entry_id": "ICB-BSR-0016", "inn": "Atezolizumab", "target": "PD-L1", "target_uniprot": "Q9NZQ7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4018", "product_url": "https://ichor.bio/atezolizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921536", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.005, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.005% main peak)" } ] }, { "entry_id": "ICB-BSR-0017", "inn": "Denosumab", "target": "RANKL", "target_uniprot": "O14788", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH4019", "product_url": "https://ichor.bio/denosumab-biosimilar-research-grade-ich4019", "rrid": "RRID:AB_2921537", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGITGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDPGTTVIMSWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVRGRYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVFYCQQYGSSPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.05, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0018", "inn": "Daratumumab", "target": "CD38", "target_uniprot": "P28907", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4020", "product_url": "https://ichor.bio/daratumumab-biosimilar-research-grade", "rrid": "RRID:AB_2921538", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.08, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0019", "inn": "Evolocumab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH4023", "product_url": "https://ichor.bio/evolocumab-biosimilar-research-grade", "rrid": "RRID:AB_2921539", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTLTSYGISWVRQAPGQGLEWMGWVSFYNGNTNYAQKLQGRGTMTTDPSTSTAYMELRSLRSDDTAVYYCARGYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "ESALTQPASVSGSPGQSITISCTGTSSDVGGYNSVSWYQQHPGKAPKLMIYEVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCNSYTSTSMVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 141.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.65, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.025, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.025% main peak)" } ] }, { "entry_id": "ICB-BSR-0020", "inn": "Ipilimumab", "target": "CTLA-4", "target_uniprot": "P16410", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4025", "product_url": "https://ichor.bio/ipilimumab-biosimilar-research-grade", "rrid": "RRID:AB_2921540", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.43, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.989, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.989% main peak)" } ] }, { "entry_id": "ICB-BSR-0021", "inn": "Obinutuzumab", "target": "CD20", "target_uniprot": "P11836", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH4026", "product_url": "https://ichor.bio/obinutuzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921541", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, ≥95% spec)" } ] }, { "entry_id": "ICB-BSR-0022", "inn": "Pembrolizumab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 kappa", "product_sku": "ICH4029", "product_url": "https://ichor.bio/pembrolizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921544", "sequences": { "heavy_chain": "QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.09, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.09% main peak)" } ] }, { "entry_id": "ICB-BSR-0023", "inn": "Pertuzumab", "target": "HER2", "target_uniprot": "P04626", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH4030", "product_url": "https://ichor.bio/pertuzumab-biosimilar-research-grade-ich4030", "rrid": "RRID:AB_2921545", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 167.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.49, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0024", "inn": "Ranibizumab", "target": "VEGF", "target_uniprot": "P15692", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4031", "product_url": "https://ichor.bio/ranibizumab-biosimilar-research-grade-ich4031", "rrid": "RRID:AB_2921546", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 167.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.28, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0025", "inn": "Ramucirumab", "target": "VEGFR2", "target_uniprot": "P35968", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH4032", "product_url": "https://ichor.bio/ramucirumab-biosimilar-research-grade", "rrid": "RRID:AB_2921547", "sequences": { "heavy_chain": "EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTDAFDIWGQGTMVTVSSASTKGPSVLPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASIGDRVTITCRASQGIDNWLGWYQQKPGKAPKLLIYDASNLDTGVPSRFSGSGSGTYFTLTISSLQAEDFAVYFCQQAKAFPPTFGGGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0026", "inn": "Secukinumab", "target": "IL17A", "target_uniprot": "Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4033", "product_url": "https://ichor.bio/secukinumab-biosimilar-research-grade", "rrid": "RRID:AB_2921548", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMNWVRQAPGKGLEWVAAINQDGSEKYYVGSVKGRFTISRDNAKNSLYLQMNSLRVEDTAVYYCVRDYYDILTDYYIHYWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPCTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 148.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.88, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.462, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.462% main peak)" } ] }, { "entry_id": "ICB-BSR-0027", "inn": "Ustekinumab", "target": "IL-12 and IL-23", "target_uniprot": "P29459", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 kappa", "product_sku": "ICH4034", "product_url": "https://ichor.bio/ustekinumab-biosimilar-research-grade", "rrid": "RRID:AB_2921549", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFTTYWLGWVRQMPGKGLDWIGIMSPVDSDIRYSPSFQGQVTMSVDKSITTAYLQWNSLKASDTAMYYCARRRPGQGYFDFWGQGTLVTVSSSSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0028", "inn": "Vedolizumab", "target": "Integrin alpha 4 + beta 7", "target_uniprot": "P13612", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH4035", "product_url": "https://ichor.bio/vedolizumab-biosimilar-research-grade-ich4035", "rrid": "RRID:AB_2921550", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKGSGYTFTSYWMHWVRQAPGQRLEWIGEIDPSESNTNYNQKFKGRVTLTVDISASTAYMELSSLRSEDTAVYYCARGGYDGWDYAIDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLAKSYGNTYLSWYLQKPGQSPQLLIYGISNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQGTHQPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0029", "inn": "Sintilimab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5001", "product_url": "https://ichor.bio/sintilimab-biosimilar-research-grade-ich5001", "rrid": "RRID:AB_2921552", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGLIIPMFDTAGYAQKFQGRVAITVDESTSTAYMELSSLRSEDTAVYYCARAEHSSTGTFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLISAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANHLPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.11, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0030", "inn": "Toripalimab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5002", "product_url": "https://ichor.bio/toripalimab-biosimilar-research-grade", "rrid": "RRID:AB_2921553", "sequences": { "heavy_chain": "QGQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPIHGLEWIGVIESETGGTAYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCAREGITTVATTYYWYFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.9, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.5, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.5% main peak)" } ] }, { "entry_id": "ICB-BSR-0031", "inn": "Camrelizumab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5003", "product_url": "https://ichor.bio/camrelizumab-biosimilar-research-grade-ich5003", "rrid": "RRID:AB_2921554", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYMMSWVRQAPGKGLEWVATISGGGANTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLYYFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCLASQTIGTWLTWYQQKPGKAPKLLIYTATSLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVYSIPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0032", "inn": "Tislelizumab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5004", "product_url": "https://ichor.bio/tislelizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921555", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLTSYGVHWIRQPPGKGLEWIGVIYADGSTNYNPSLKSRVTISKDTSKNQVSLKLSSVTAADTAVYYCARAYGNYWYIDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSESVSNDVAWYQQKPGQPPKLLINYAFHRFTGVPDRFSGSGYGTDFTLTISSLQAEDVAVYYCHQAYSSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0033", "inn": "Durvalumab", "target": "PD-L1", "target_uniprot": "Q9NZQ7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5005", "product_url": "https://ichor.bio/durvalumab-biosimilar-research-grade-ich5005", "rrid": "RRID:AB_2921556", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQRVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0034", "inn": "Aducanumab", "target": "Beta Amyloid", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5008", "product_url": "https://ichor.bio/aducanumab-biosimilar-research-grade", "rrid": "RRID:AB_2921558", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWFDGTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGARRGPYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.71, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0035", "inn": "Gantenerumab", "target": "Beta Amyloid", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5009", "product_url": "https://ichor.bio/gantenerumab-biosimilar-research-grade", "rrid": "RRID:AB_2921559", "sequences": { "heavy_chain": "QVELVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAINASGTRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGKGNTHKPYGYVRYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVLTQSPATLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGVPARFSGSGSGTDFTLTISSLEPEDFATYYCLQIYNMPITFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.58, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0036", "inn": "Nesvacumab", "target": "Angiopoietin 2", "target_uniprot": "O15123", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5010", "product_url": "https://ichor.bio/nesvacumab-biosimilar-research-grade", "rrid": "RRID:AB_2921560", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYDIHWVRQATGKGLEWVSAIGPAGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGLITFGGLIAPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYDNSQTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0037", "inn": "Belantamab", "target": "BCMA", "target_uniprot": "Q02223", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5011", "product_url": "https://ichor.bio/belantamab-biosimilar-research-grade", "rrid": "RRID:AB_2921626", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNYWMHWVRQAPGQGLEWMGATYRGHSDTYYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGAIYDGYDVLDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKLLIYYTSNLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYRKLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0038", "inn": "Sutimlimab", "target": "C1s", "target_uniprot": "P09871", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5012", "product_url": "https://ichor.bio/sutimlimab-biosimilar-research-grade", "rrid": "RRID:AB_2921561", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVATISSGGSHTYYLDSVKGRFTISRDNSKNTLYLQMNSLRAEDTALYYCARLFTGYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "QIVLTQSPATLSLSPGERATMSCTASSSVSSSYLHWYQQKPGKAPKLWIYSTSNLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCHQYYRLPPITFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0039", "inn": "Girentuximab", "target": "Carbonic Anhydrase IX", "target_uniprot": "Q16790", "format": "bispecific / multi-chain (4 chains)", "isotype": "IgG1 - kappa", "product_sku": "ICH5013", "product_url": "https://ichor.bio/girentuximab-biosimilar-research-grade", "rrid": "RRID:AB_2921562", "sequences": { "heavy_chain": "DVKLVESGGGLVKLGGSLKLSCAASGFTFSNYYMSWVRQTPEKRLELVAAINSDGGITYYLDTVKGRFTISRDNAKNTLYLQMSSLKSEDTALFYCARHRSGYFSMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSQRFMSTTVGDRVSITCKASQNVVSAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADFFCQQYSNYPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.178, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.178% main peak)" } ] }, { "entry_id": "ICB-BSR-0040", "inn": "Utomilumab", "target": "4-1BB", "target_uniprot": "Q07011", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5014", "product_url": "https://ichor.bio/utomilumab-biosimilar-research-grade", "rrid": "RRID:AB_2921563", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLRISCKGSGYSFSTYWISWVRQMPGKGLEWMGKIYPGDSYTNYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGYGIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "SYELTQPPSVSVSPGQTASITCSGDNIGDQYAHWYQQKPGQSPVLVIYQDKNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCATYTGFGSLAVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.1, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0041", "inn": "Urelumab", "target": "4-1BB", "target_uniprot": "Q07011", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5015", "product_url": "https://ichor.bio/urelumab-biosimilar-research-grade", "rrid": "RRID:AB_2921564", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGNYDWYFDLWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPALTFCGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.59, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.06, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.06% main peak)" } ] }, { "entry_id": "ICB-BSR-0042", "inn": "Atibuclimab", "target": "CD14", "target_uniprot": "P08571", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5016", "product_url": "https://ichor.bio/atibuclimab-biosimilar-research-grade", "rrid": "RRID:AB_2921565", "sequences": { "heavy_chain": "DVQLQQSGPGLVKPSQSLSLTCTVTGYSITSDSAWNWIRQFPGNRLEWMGYISYSGSTSYNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYYCVRGLRFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVLTQSPASLAVSLGQRATISCRASESVDSYVNSFLHWYQQKPGQPPKLLIYRASNLQSGIPARFSGSGSRTDFTLTINPVEADDVATYYCQQSNEDPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0043", "inn": "Monalizumab", "target": "NKG2A", "target_uniprot": "P26715", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5017", "product_url": "https://ichor.bio/monalizumab-biosimilar-research-grade-ich5017", "rrid": "RRID:AB_2921566", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWMNWVRQAPGQGLEWMGRIDPYDSETHYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGYDFDVGTLYWFFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASENIYSYLAWYQQKPGKAPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGTPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.12, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.083, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.083% main peak)" } ] }, { "entry_id": "ICB-BSR-0044", "inn": "Glofitamab", "target": "CD3 + CD20", "target_uniprot": "P07766;P11836", "format": "T-cell engager (TCB) | 2:1 TCB — bivalent tumor + monovalent CD3 | 2 Fabs + 1 CrossFab + heterodimeric Fc (5 chains)", "isotype": "Humanized IgG1", "product_sku": "ICH5019", "product_url": "https://ichor.bio/glofitamab-biosimilar-research-grade", "rrid": "RRID:AB_2921629", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTVAAPSVFIFPPSDRKLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 194.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0045", "inn": "Daclizumab", "target": "IL2RA", "target_uniprot": "P01589", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5021", "product_url": "https://ichor.bio/daclizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921568", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTSYRMHWVRQAPGQGLEWIGYINPSTGYTEYNQKFKDKATITADESTNTAYMELSSLRSEDTAVYYCARGGGVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSTLSASVGDRVTITCSASSSISYMHWYQQKPGKAPKLLIYTTSNLASGVPARFSGSGSGTEFTLTISSLQPDDFATYYCHQRSTYPLTFGQGTKVEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.935, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.935% main peak)" } ] }, { "entry_id": "ICB-BSR-0046", "inn": "Varlilumab", "target": "CD27", "target_uniprot": "P26842", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5022", "product_url": "https://ichor.bio/varlilumab-biosimilar-research-grade", "rrid": "RRID:AB_2921569", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGSGNWGFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGSS", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISRWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNTYPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0047", "inn": "Mosunetuzumab", "target": "CD3e + CD20", "target_uniprot": "P07766", "format": "bispecific / multi-chain (4 chains)", "isotype": "IgG1 - kappa", "product_sku": "ICH5026", "product_url": "https://ichor.bio/mosunetuzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921631", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYNMHWVRQAPGKGLEWVGAIYPGNGDTSYNQKFKGRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARVVYYSNSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASSSVSYMHWYQQKPGKAPKPLIYAPSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSFNPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.36, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0048", "inn": "Odronextamab", "target": "CD3 + CD20", "target_uniprot": "P07766;P11836", "format": "bispecific / multi-chain (3 chains)", "isotype": "IgG4 - kappa", "product_sku": "ICH5027", "product_url": "https://ichor.bio/odronextamab-biosimilar-research-grade", "rrid": "RRID:AB_2921632", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYTMHWVRQAPGKGLEWVSGISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDNSGYGHYYYGMDVWGQGTTVTVASASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNRFTQKSLSLSLGK", "light_chain": "AEIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQHYINWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 122.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.66, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0049", "inn": "Isatuximab", "target": "CD38", "target_uniprot": "P28907", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5028", "product_url": "https://ichor.bio/isatuximab-biosimilar-research-grade", "rrid": "RRID:AB_2921572", "sequences": { "heavy_chain": "QVQLVQSGAEVAKPGTSVKLSCKASGYTFTDYWMQWVKQRPGQGLEWIGTIYPGDGDTGYAQKFQGKATLTADKSSKTVYMHLSSLASEDSAVYYCARGDYYGSNSLDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSHLSMSTSLGDPVSITCKASQDVSTVVAWYQQKPGQSPRRLIYSASYRYIGVPDRFTGSGAGTDFTFTISSVQAEDLAVYYCQQHYSPPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0050", "inn": "Ibalizumab", "target": "CD4", "target_uniprot": "P01730", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5029", "product_url": "https://ichor.bio/ibalizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921573", "sequences": { "heavy_chain": "QVQLQQSGPEVVKPGASVKMSCKASGYTFTSYVIHWVRQKPGQGLDWIGYINPYNDGTDYDEKFKGKATLTSDTSTSTAYMELSSLRSEDTAVYYCAREKDNYATGAWFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPDSLAVSLGERVTMNCKSSQSLLYSTNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYYCQQYYSYRTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.81, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0051", "inn": "Dacetuzumab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5030", "product_url": "https://ichor.bio/dacetuzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921574", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYYIHWVRQAPGKGLEWVARVIPNAGGTSYNQKFKGRFTLSVDNSKNTAYLQMNSLRAEDTAVYYCAREGIYWWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGNTFLHWYQQKPGKAPKLLIYTVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCSQTTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.59, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98% main peak)" } ] }, { "entry_id": "ICB-BSR-0052", "inn": "Sotigalimab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5031", "product_url": "https://ichor.bio/sotigalimab-biosimilar-research-grade", "rrid": "RRID:AB_2921575", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFSFSSTYVCWVRQAPGKGLEWIACIYTGDGTNYSASWAKGRFTISKDSSKNTVYLQMNSLRAEDTAVYFCARPDITYGFAINFWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVEHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTIKCQASQSISSRLAWYQQKPGKPPKLLIYRASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQCTGYGISWPIGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.46, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0053", "inn": "Selicrelumab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5032", "product_url": "https://ichor.bio/selicrelumab-biosimilar-research-grade", "rrid": "RRID:AB_2921576", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPDSGGTNYAQKFQGRVTMTRDTSISTAYMELNRLRSDDTAVYYCARDQPLGYCTNGVCSYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGIYSWLAWYQQKPGKAPNLLIYTASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANIFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.84, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.435, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.435% main peak)" } ] }, { "entry_id": "ICB-BSR-0054", "inn": "Lemzoparlimab", "target": "CD47", "target_uniprot": "Q08722", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5034", "product_url": "https://ichor.bio/lemzoparlimab-biosimilar-research-grade", "rrid": "RRID:AB_2921578", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGLTFERAWMNWVRQAPGKGLEWVGRIKRKTDGETTDYAAPVKGRFSISRDDSKNTLYLQMNSLKTEDTAVYYCAGSNRAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLYAGNNRNYLAWYQQKPGQPPKLLINQASTRASGVPDRFSGSGSGTEFTLIISSLQAEDVAIYYCQQYYTPPLAFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0055", "inn": "Magrolimab", "target": "CD47", "target_uniprot": "Q08722", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4", "product_sku": "ICH5036", "product_url": "https://ichor.bio/magrolimab-biosimilar-research-grade", "rrid": "RRID:AB_2921580", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYNMHWVRQAPGQRLEWMGTIYPGNDDTSYNQKFKDRVTITADTSASTAYMELSSLRSEDTAVYYCARGGYRAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSIVYSNGNTYLGWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.066, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.066% main peak)" } ] }, { "entry_id": "ICB-BSR-0056", "inn": "Cusatuzumab", "target": "CD70", "target_uniprot": "P32970", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5037", "product_url": "https://ichor.bio/cusatuzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921581", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSVYYMNWVRQAPGKGLEWVSDINNEGGTTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCARDAGYSNHVPIFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QAVVTQEPSLTVSPGGTVTLTCGLKSGSVTSDNFPTWYQQTPGQAPRLLIYNTNTRHSGVPDRFSGSILGNKAALTITGAQADDEAEYFCALFISNPSVEFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0057", "inn": "Oleclumab", "target": "CD73", "target_uniprot": "P21589", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5038", "product_url": "https://ichor.bio/oleclumab-biosimilar-research-grade", "rrid": "RRID:AB_2921582", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAYSWVRQAPGKGLEWVSAISGSGGRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLGYGRVDEWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSLSNIGRNPVNWYQQLPGTAPKLLIYLDNLRLSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSHPGWTFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.22, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0058", "inn": "Polatuzumab", "target": "CD79b", "target_uniprot": "P40259", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5039", "product_url": "https://ichor.bio/polatuzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921628", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.63, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0059", "inn": "Tusamitamab", "target": "CEACAM5", "target_uniprot": "P06731", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5040", "product_url": "https://ichor.bio/tusamitamab-biosimilar-research-grade", "rrid": "RRID:AB_2921583", "sequences": { "heavy_chain": "EVQLQESGPGLVKPGGSLSLSCAASGFVFSSYDMSWVRQTPERGLEWVAYISSGGGITYAPSTVKGRFTVSRDNAKNTLYLQMNSLTSEDTAVYYCAAHYFGSSGPFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPASLSASVGDRVTITCRASENIFSYLAWYQQKPGKSPKLLVYNTRTLAEGVPSRFSGSGSGTDFSLTISSLQPEDFATYYCQHHYGTPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0060", "inn": "Cibisatamab", "target": "CEA + CD3", "target_uniprot": "P06731;P07766", "format": "T-cell engager (TCB) | 2:1 TCB — bivalent tumor + monovalent CD3 | 2 Fabs + 1 CrossFab + heterodimeric Fc (5 chains)", "isotype": "Humanized IgG1", "product_sku": "ICH5041", "product_url": "https://ichor.bio/cibisatamab-biosimilar-research-grade", "rrid": "RRID:AB_2921633", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTEFGMNWVRQAPGQGLEWMGWINTKTGEATYVEEFKGRVTFTTDTSTSTAYMELRSLRSDDTAVYYCARWDFAYYVEAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASAAVGTYVAWYQQKPGKAPKLLIYSASYRKRGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCHQYYTYPLFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 194.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.5, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95.928, "unit": "%", "method": "SEC-HPLC (supplier CoA, 95.928% main peak)" } ] }, { "entry_id": "ICB-BSR-0061", "inn": "Tinurilimab", "target": "CEACAM6", "target_uniprot": "P40199", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5042", "product_url": "https://ichor.bio/tinurilimab-biosimilar-research-grade", "rrid": "RRID:AB_2921584", "sequences": { "heavy_chain": "QVTLRESGPALVKPTQTLTLTCTFSGFSLSTYGIGVGWIRQPPGKALEWLAHIWWNDNKYYSTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARISLPYFDYWGQGTTLTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQLTQSPSFLSASVGDRVTITCKASQNVGTAVAWYQQKPGKAPKLLIYSASNRYTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.18, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0062", "inn": "Erenumab", "target": "CGRP receptor", "target_uniprot": "Q16602", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5043", "product_url": "https://ichor.bio/erenumab-biosimilar-research-grade", "rrid": "RRID:AB_2921585", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAVISFDGSIKYSVDSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCARDRLNYYDSSGYYHYKYYGMAVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSTTLGITGLQTGDEADYYCGTWDSRLSAVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.48, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0063", "inn": "Eptinezumab", "target": "CALCA, CALCB", "target_uniprot": "P01258", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 N297A-Kappa", "product_sku": "ICH5044", "product_url": "https://ichor.bio/eptinezumab-biosimilar-research-grade", "rrid": "RRID:AB_2921586", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAVSGIDLSGYYMNWVRQAPGKGLEWVGVIGINGATYYASWAKGRFTISRDNSKTTVYLQMNSLRAEDTAVYFCARGDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDARVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QVLTQSPSSLSASVGDRVTINCQASQSVYHNTYLAWYQQKPGKVPKQLIYDASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLGSYDCTNGDCFVFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0064", "inn": "Fremanezumab", "target": "CGRP", "target_uniprot": "P06881", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5045", "product_url": "https://ichor.bio/fremanezumab-biosimilar-research-grade", "rrid": "RRID:AB_2921587", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWISWVRQAPGKGLEWVAEIRSESDASATHYAEAVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCLAYFDYGLAIQNYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCKASKRVTTYVSWYQQKPGQAPRLLIYGASNRYLGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCSQSYNYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0065", "inn": "Galcanezumab", "target": "CGRP", "target_uniprot": "P06881", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P/F234A/L235A/KDel)-Kappa", "product_sku": "ICH5046", "product_url": "https://ichor.bio/galcanezumab-biosimilar-research-grade", "rrid": "RRID:AB_2921588", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFGNYWMQWVRQAPGQGLEWMGAIYEGTGKTVYIQKFADRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSDYVSGFGYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASKDISKYLNWYQQKPGKAPKLLIYYTSGYHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGDALPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.66, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.735, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.735% main peak)" } ] }, { "entry_id": "ICB-BSR-0066", "inn": "Zolbetuximab", "target": "Claudin 18.2", "target_uniprot": "P56856", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 K97R-Kappa", "product_sku": "ICH5047", "product_url": "https://ichor.bio/zolbetuximab-biosimilar-research-grade", "rrid": "RRID:AB_2921589", "sequences": { "heavy_chain": "QVQLQQPGAELVRPGASVKLSCKASGYTFTSYWINWVKQRPGQGLEWIGNIYPSDSYTNYNQKFKDKATLTVDKSSSTAYMQLSSPTSEDSAVYYCTRSWRGNSFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQNDYSYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0067", "inn": "Rovalpituzumab", "target": "DLL3", "target_uniprot": "Q9NYJ7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5048", "product_url": "https://ichor.bio/rovalpituzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921590", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGEPTYADDFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARIGDSSPSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVMTQSPATLSVSPGERATLSCKASQSVSNDVVWYQQKPGQAPRLLIYYASNRYTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQDYTSPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0068", "inn": "Batoclimab", "target": "FcRn", "target_uniprot": "P55899", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Lambda2", "product_sku": "ICH5049", "product_url": "https://ichor.bio/batoclimab-biosimilar-research-grade", "rrid": "RRID:AB_2921591", "sequences": { "heavy_chain": "QLLLQESGPGLVKPSETLSLTCTVSGGSLSSSFSYWVWIRQPPGKGLEWIGTIYYSGNTYYNPSLKSRLTISVDTSKNHFSLKLSSVTAADTAVYYCARRAGILTGYLDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "SYVLTQSPSVSVAPGQTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSASNSGNTATLTISRVEAGDEADYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.073, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.073% main peak)" } ] }, { "entry_id": "ICB-BSR-0069", "inn": "Nipocalimab", "target": "FcRn", "target_uniprot": "P55899", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda3", "product_sku": "ICH5050", "product_url": "https://ichor.bio/nipocalimab-biosimilar-research-grade", "rrid": "RRID:AB_2921592", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYAMGWVRQAPGKGLEWVSSIGASGSQTRYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLAIGDSYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QSALTQPASVSGSPGQSITISCTGTGSDVGSYNLVSWYQQHPGKAPKLMIYGDSERPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYAGSGIYVFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 141.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0070", "inn": "Rozanolixizumab", "target": "FcRn", "target_uniprot": "P55899", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5051", "product_url": "https://ichor.bio/rozanolixizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921593", "sequences": { "heavy_chain": "EVPLVESGGGLVQPGGSLRLSCAVSGFTFSNYGMVWVRQAPGKGLEWVAYIDSDGDNTYYRDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCTTGIVRPFLYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKSSQSLVGASGKTYLYWLFQKPGKAPKRLIYLVSTLDSGIPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQGTHFPHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0071", "inn": "Aprutumab", "target": "FGFR2", "target_uniprot": "P21802", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5052", "product_url": "https://ichor.bio/aprutumab-biosimilar-research-grade", "rrid": "RRID:AB_2921594", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGTSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARVRYNWNHGDWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYENYNRPAGVPDRFSGSKSGTSASLAISGLRSEDEADYYCSSWDDSLNYWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0072", "inn": "Bemarituzumab", "target": "FGFR2b", "target_uniprot": "P21802", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5053", "product_url": "https://ichor.bio/bemarituzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921595", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYIFTTYNVHWVRQAPGQGLEWIGSIYPDNGDTSYNQNFKGRATITADKSTSTAYMELSSLRSEDTAVYYCARGDFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQGVSNDVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQHSTTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0073", "inn": "Mavrilimumab", "target": "GM-CSF", "target_uniprot": "P04141", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - lambda2", "product_sku": "ICH5054", "product_url": "https://ichor.bio/mavrilimumab-biosimilar-research-grade", "rrid": "RRID:AB_2921596", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGYTLTELSIHWVRQAPGKGLEWMGGFDPEENEIVYAQRFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCAIVGSFSPLTLGLWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSGSNIGAPYDVSWYQQLPGTAPKLLIYHNNKRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCATVEAGLSGSVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0074", "inn": "Codrituzumab", "target": "GPC3", "target_uniprot": "P51654", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5055", "product_url": "https://ichor.bio/codrituzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921597", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGALDPKTGDTAYSQKFKGRVTLTADKSTSTAYMELSSLTSEDTAVYYCTRFYSYTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLVHSNRNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQNTHVPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0075", "inn": "Margetuximab", "target": "HER2", "target_uniprot": "P04626", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5057", "product_url": "https://ichor.bio/margetuximab-biosimilar-research-grade", "rrid": "RRID:AB_2921599", "sequences": { "heavy_chain": "QVQLQQSGPELVKPGASLKLSCTASGFNIKDTYIHWVKQRPEQGLEWIGRIYPTNGYTRYDPKFQDKATITADTSSNTAYLQVSRLTSEDTAVYYCSRWGGDGFYAMDYWGQGASVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELVGGPSVFLLPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPPEEQYNSTLRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPLVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSHKFMSTSVGDRVSITCKASQDVNTAVAWYQQKPGHSPKLLIYSASFRYTGVPDRFTGSRSGTDFTFTISSVQAEDLAVYYCQQHYTTPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0076", "inn": "Lebrikizumab", "target": "IL-13", "target_uniprot": "P35225", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 S228P-Kappa", "product_sku": "ICH5058", "product_url": "https://ichor.bio/lebrikizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921600", "sequences": { "heavy_chain": "QVTLRESGPALVKPTQTLTLTCTVSGFSLSAYSVNWIRQPPGKALEWLAMIWGDGKIVYNSALKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCAGDGYYPYAMDNWGQGSLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPDSLSVSLGERATINCRASKSVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQNNEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.41, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.923, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.923% main peak)" } ] }, { "entry_id": "ICB-BSR-0077", "inn": "Tralokinumab", "target": "IL-13", "target_uniprot": "P35225", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 S228P-Kappa", "product_sku": "ICH5059", "product_url": "https://ichor.bio/tralokinumab-biosimilar-research-grade", "rrid": "RRID:AB_2921601", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGLSWVRQAPGQGLEWMGWISANNGDTNYGQEFQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDSSSSWARWFFDLWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "SYVLTQPPSVSVAPGKTARITCGGNIIGSKLVHWYQQKPGQAPVLVIYDDGDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDTGSDPVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.81, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0078", "inn": "Brodalumab", "target": "IL-17RA", "target_uniprot": "Q96F46;Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5060", "product_url": "https://ichor.bio/brodalumab-biosimilar-research-grade", "rrid": "RRID:AB_2921602", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYGISWVRQAPGQGLEWMGWISTYSGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARRQLYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWFQQKPGQAPRPLIYDASTRATGVPARFSGSGSGTDFTLTISSLQSEDFAVYYCQQYDNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.19, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0079", "inn": "Etokimab", "target": "IL-33", "target_uniprot": "O95760", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5061", "product_url": "https://ichor.bio/etokimab-biosimilar-research-grade", "rrid": "RRID:AB_2921603", "sequences": { "heavy_chain": "QVQLMQSGAEVKKPGASVKVSCKASGYTFTSYWMHWVRQAPGQGLEWMGTIYPRNSNTDYNQKFKARVTMTRDTSTSTVYMELSSLRSEDTAVYYCARPLYYYLTSPPTLFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSFLSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQAKTYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.7, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0080", "inn": "Dupilumab", "target": "IL-4R alpha", "target_uniprot": "P24394", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5062", "product_url": "https://ichor.bio/dupilumab-biosimilar-research-grade", "rrid": "RRID:AB_2921604", "sequences": { "heavy_chain": "EVQLVESGGGLEQPGGSLRLSCAGSGFTFRDYAMTWVRQAPGKGLEWVSSISGSGGNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRLSITIRPRYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLYSIGYNYLDWYLQKSGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGFYYCMQALQTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.78, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0081", "inn": "Clazakizumab", "target": "IL-6", "target_uniprot": "P05231", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5063", "product_url": "https://ichor.bio/clazakizumab-biosimilar-research-grade", "rrid": "RRID:AB_2921605", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFSLSNYYVTWVRQAPGKGLEWVGIIYGSDETAYATSAIGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDDSSDWDAKFNLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "AIQMTQSPSSLSASVGDRVTITCQASQSINNELSWYQQKPGKAPKLLIYRASTLASGVPSRFSGSGSGTDFTLTISSLQPDDFATYYCQQGYSLRNIDNAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0082", "inn": "Guselkumab", "target": "IL-23", "target_uniprot": "Q9NPF7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Lambda3", "product_sku": "ICH5064", "product_url": "https://ichor.bio/guselkumab-biosimilar-research-grade", "rrid": "RRID:AB_2921606", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFSNYWIGWVRQMPGKGLEWMGIIDPSNSYTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARWYYKPFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSSSNIGSGYDVHWYQQLPGTAPKLLIYGNSKRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCASWTDGLSLVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0083", "inn": "Simtuzumab", "target": "LOXL2", "target_uniprot": "Q9Y4K0", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5068", "product_url": "https://ichor.bio/simtuzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921610", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYAFTYYLIEWVRQAPGQGLEWIGVINPGSGGTNYNEKFKGRATITADKSTSTAYMELSSLRSEDTAVYFCARNWMNFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSKSLLHSNGNTYLYWFLQKPGQSPQFLIYRMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQHLEYPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0084", "inn": "Amatuximab", "target": "MSLN", "target_uniprot": "Q13421", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5069", "product_url": "https://ichor.bio/amatuximab-biosimilar-research-grade", "rrid": "RRID:AB_2921611", "sequences": { "heavy_chain": "QVQLQQSGPELEKPGASVKISCKASGYSFTGYTMNWVKQSHGKSLEWIGLITPYNGASSYNQKFRGKATLTVDKSSSTAYMDLLSLTSEDSAVYFCARGGYDGRGFDYWGSGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIELTQSPAIMSASPGEKVTMTCSASSSVSYMHWYQQKSGTSPKRWIYDTSKLASGVPGRFSGSGSGNSYSLTISSVEAEDDATYYCQQWSKHPLTFGSGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0085", "inn": "Enfortumab Vedotin", "target": "Nectin-4", "target_uniprot": "Q96NY8", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5070V", "product_url": "https://ichor.bio/enfortumab-vedotin-biosimilar-research-grade-ich5070v", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYNMNWVRQAPGKGLEWVSYISSSSSTIYYADSVKGRFTISRDNAKNSLSLQMNSLRDEDTAVYYCARAYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISGWLAWYQQKPGKAPKFLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0086", "inn": "Sacituzumab", "target": "TACSTD2", "target_uniprot": "P09758", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5076", "product_url": "https://ichor.bio/sacituzumab-biosimilar-research-grade", "rrid": "RRID:AB_2921618", "sequences": { "heavy_chain": "QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTYTGEPTYTDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCARGGFGSSYWYFDVWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVSITCKASQDVSIAVAWYQQKPGKAPKLLIYSASYRYTGVPDRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGAGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.992, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.992% main peak)" } ] }, { "entry_id": "ICB-BSR-0087", "inn": "Fresolimumab", "target": "TGF beta 1", "target_uniprot": "P01137", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 S228P-Kappa", "product_sku": "ICH5077", "product_url": "https://ichor.bio/fresolimumab-biosimilar-research-grade", "rrid": "RRID:AB_2921619", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFSSNVISWVRQAPGQGLEWMGGVIPIVDIANYAQRFKGRVTITADESTSTTYMELSSLRSEDTAVYYCASTLGLVLDAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "ETVLTQSPGTLSLSPGERATLSCRASQSLGSSYLAWYQQKPGQAPRLLIYGASSRAPGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYADSPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.55, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.327, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.327% main peak)" } ] }, { "entry_id": "ICB-BSR-0088", "inn": "Tiragolumab", "target": "TIGIT", "target_uniprot": "Q495A1", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5078", "product_url": "https://ichor.bio/tiragolumab-biosimilar-research-grade", "rrid": "RRID:AB_2921620", "sequences": { "heavy_chain": "EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 148.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.88, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.179, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.179% main peak)" } ] }, { "entry_id": "ICB-BSR-0089", "inn": "Sabatolimab", "target": "Tim-3", "target_uniprot": "Q8TDQ0", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 S228P-Kappa", "product_sku": "ICH5079", "product_url": "https://ichor.bio/sabatolimab-biosimilar-research-grade", "rrid": "RRID:AB_2921621", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGDIYPGNGDTSYNQKFKGRVTITADKSTSTVYMELSSLRSEDTAVYYCARVGGAFPMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASESVEYYGTSLMQWYQQKPGKAPKLLIYAASNVESGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQQSRKDPSTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0090", "inn": "Belimumab", "target": "BAFF", "target_uniprot": "Q9Y275", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 E239D ,M241L-lambda3 K83R", "product_sku": "ICH5080", "product_url": "https://ichor.bio/belimumab-biosimilar-research-grade", "rrid": "RRID:AB_2921622", "sequences": { "heavy_chain": "QVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "SSELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.08, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0091", "inn": "Onvatilimab", "target": "VISTA", "target_uniprot": "Q9H7M9", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5081", "product_url": "https://ichor.bio/onvatilimab-biosimilar-research-grade", "rrid": "RRID:AB_2921623", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARSSYGWSYEFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSIDTRLNWYQQKPGKAPKLLIYSASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSAYNPITFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0092", "inn": "Rosopatamab", "target": "PMSA", "target_uniprot": "Q04609", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5083", "product_url": "https://ichor.bio/rosopatamab-biosimilar-research-grade", "rrid": "RRID:AB_3075719", "sequences": { "heavy_chain": "EVQLVQSGPEVKKPGATVKISCKTSGYTFTEYTIHWVKQAPGKGLEWIGNINPNNGGTTYNQKFEDKATLTVDKSTDTAYMELSSLRSEDTAVYYCAAGWNFDYWGQGTLLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSTSVGDRVTLTCKASQDVGTAVDWYQQKPGPSPKLLIYWASTRHTGIPSRFSGSGSGTDFTLTISSLQPEDFADYYCQQYNSYPLTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.14, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.625, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.625% main peak)" } ] }, { "entry_id": "ICB-BSR-0093", "inn": "Rolinsatamab", "target": "PRLR", "target_uniprot": "P16471", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(S239C)-Kappa", "product_sku": "ICH5084", "product_url": "https://ichor.bio/rolinsatamab-biosimilar-research-grade", "rrid": "RRID:AB_3075720", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGYTFTTYWMHWVRQAPGQGLEWIGEIDPSDSYSNYNQKFKDRATLTVDKSTSTAYMELSSLRSEDTAVYYCARNGGLGPAWFSYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCKASQYVGTAVAWYQQKPGKSPKLLIYSASNRYTGVPSRFSDSGSGTDFTLTISSLQPEDFATYFCQQYSSYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.18, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0094", "inn": "Iratumumab", "target": "CD30", "target_uniprot": "P28908", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L/436YDel)-Kappa", "product_sku": "ICH5085", "product_url": "https://ichor.bio/iratumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075721", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSAYYWSWIRQPPGKGLEWIGDINHGGGTNYNPSLKSRVTISVDTSKNQFSLKLNSVTAADTAVYYCASLTAYWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHTQKSLSLSPGK", "light_chain": "DIQMTQSPTSLSASVGDRVTITCRASQGISSWLTWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYDSYPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0095", "inn": "Sofituzumab Vedotin", "target": "CA125 / MUC16", "target_uniprot": "Q8WXI7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5086V", "product_url": "https://ichor.bio/sofituzumab-vedotin-biosimilar-research-grade-ich5086v", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSITNDYAWNWVRQAPGKGLEWVGYISYSGYTTYNPSLKSRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARWTSGLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASDLIHNWLAWYQQKPGKAPKLLIYGATSLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYWTTPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0096", "inn": "Nadunolimab", "target": "IL1RAP", "target_uniprot": "Q9NPH3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(KDel)-Kappa", "product_sku": "ICH5088", "product_url": "https://ichor.bio/nadunolimab-biosimilar-research-grade-ich5088", "rrid": "RRID:AB_3075724", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFTSSWMNWVRQAPGQGLEWMGRIYPGDGNTHYAQKFQGRVTLTADKSTSTAYMELSSLRSEDTAVYYCGEGYLDPMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQGINNYLNWYQQKPGKAPKLLIHYTSGLHAGVPSRFSGSGSGTDYTLTISSLEPEDVATYYCQQYSILPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.35, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.35% main peak)" } ] }, { "entry_id": "ICB-BSR-0097", "inn": "Pivekimab", "target": "IL-3RA", "target_uniprot": "P26951", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L/S442C/KDel)-Kappa", "product_sku": "ICH5089", "product_url": "https://ichor.bio/pivekimab-biosimilar-research-grade", "rrid": "RRID:AB_3075725", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFTSSIMHWVRQAPGQGLEWIGYIKPYNDGTKYNEKFKGRATLTSDRSTSTAYMELSSLRSEDTAVYYCAREGGNDYYDTMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLCLSPG", "light_chain": "EIQMTQSPSSLSASVGDRVTITCRASQDINSYLSWFQQKPGKAPKTLIYRVNRLVDGVPSRFSGSGSGNDYTLTISSLQPEDFATYYCLQYDAFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.04, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0098", "inn": "Camidanlumab", "target": "IL2RA", "target_uniprot": "P01589", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R/E356D/M358L)-Kappa", "product_sku": "ICH5090", "product_url": "https://ichor.bio/camidanlumab-biosimilar-research-grade", "rrid": "RRID:AB_3075726", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSRYIINWVRQAPGQGLEWMGRIIPILGVENYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARKDWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0099", "inn": "Indusatumab", "target": "GC-C", "target_uniprot": "P25092", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5091", "product_url": "https://ichor.bio/indusatumab-biosimilar-research-grade", "rrid": "RRID:AB_3075727", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVFGGSFSGYYWSWIRQPPGKGLEWIGEINHRGNTNDNPSLKSRVTISVDTSKNQFALKLSSVTAADTAVYYCARERGYTYGNFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSRNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTIGSLQSEDFAVYYCQQYKTWPRTFGQGTNVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.59, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0100", "inn": "Edrecolomab", "target": "CD326", "target_uniprot": "P16422", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "Mouse IgG2a-kappa", "product_sku": "ICH5092", "product_url": "https://ichor.bio/edrecolomab-biosimilar-research-grade", "rrid": "RRID:AB_3075728", "sequences": { "heavy_chain": "QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGGTNYNEKFKGKATLTADKSSSTAYMQLSSLTSDDSAVYFCARDGPWFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "NIVMTQSPKSMSMSVGERVTLTCKASENVVTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYHCGQGYSYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0101", "inn": "Pinatuzumab Vedotin", "target": "Siglec-2 / CD22", "target_uniprot": "P20273", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5093V", "product_url": "https://ichor.bio/pinatuzumab-vedotin-biosimilar-research-grade-ich5093v", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYEFSRSWMNWVRQAPGKGLEWVGRIYPGDGDTNYSGKFKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARDGSSWDWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSIVHSVGNTFLEWYQQKPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCFQGSQFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0102", "inn": "Upifitamab", "target": "SLC34A2", "target_uniprot": "O95436", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R/E356D/M358L)-Kappa", "product_sku": "ICH5094", "product_url": "https://ichor.bio/upifitamab-biosimilar-research-grade", "rrid": "RRID:AB_3075730", "sequences": { "heavy_chain": "QVQLVQSGAEVVKPGASVKMSCKASGYTFTGYNIHWVKQAPGQGLEWIGAIYPGNGDTSYKQKFRGRATLTADTSTSTVYMELSSLRSEDSAVYYCARGETARATFAYWGQGTLVTVSSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASQDIGNFLNWYQQKPGKTVKVLIYYTSSLYSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYSKLPLTFGQGTKLELKRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0103", "inn": "Omburtamab", "target": "CD276", "target_uniprot": "Q5ZPR3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "Mouse IgG1-Kappa", "product_sku": "ICH5095", "product_url": "https://ichor.bio/omburtamab-biosimilar-research-grade", "rrid": "RRID:AB_3075731", "sequences": { "heavy_chain": "QVQLQQSGAELVKPGASVKLSCKASGYTFTNYDINWVRQRPEQGLEWIGWIFPGDGSTQYNEKFKGKATLTTDTSSSTAYMQLSRLTSEDSAVYFCARQTTATWFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "light_chain": "DIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.3, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0104", "inn": "Daxdilimab", "target": "ILT-7", "target_uniprot": "P59901", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Lambda2(K83R）", "product_sku": "ICH5096", "product_url": "https://ichor.bio/daxdilimab-biosimilar-research-grade", "rrid": "RRID:AB_3075732", "sequences": { "heavy_chain": "QVQLQQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYNGNTNYAQKLQGRVTMTIDTSTSTAYMELRSLRSDDTAVYYCARNGLWGWDSDAFDIWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTVVFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0105", "inn": "Mirvetuximab", "target": "FOLR1", "target_uniprot": "P15328", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L/KDel)-Kappa", "product_sku": "ICH5097", "product_url": "https://ichor.bio/mirvetuximab-biosimilar-research-grade", "rrid": "RRID:AB_3075733", "sequences": { "heavy_chain": "QVQLVQSGAEVVKPGASVKISCKASGYTFTGYFMNWVKQSPGQSLEWIGRIHPYDGDTFYNQKFQGKATLTVDKSSNTAHMELLSLTSEDFAVYYCTRYDGSRAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVLTQSPLSLAVSLGQPAIISCKASQSVSFAGTSLMHWYHQKPGQQPRLLIYRASNLEAGVPDRFSGSGSKTDFTLTISPVEAEDAATYYCQQSREYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.834, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.834% main peak)" } ] }, { "entry_id": "ICB-BSR-0106", "inn": "Ieramilimab", "target": "LAG3", "target_uniprot": "P18627", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P/KDel)-Kappa", "product_sku": "ICH5098", "product_url": "https://ichor.bio/ieramilimab-biosimilar-research-grade", "rrid": "RRID:AB_3075734", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGFTLTNYGMNWVRQARGQRLEWIGWINTDTGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPPYYYGTNNAEAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCSSSQDISNYLNWYLQKPGQSPQLLIYYTSTLHLGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYYNLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.26, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0107", "inn": "Veltuzumab", "target": "CD20", "target_uniprot": "P11836", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5099", "product_url": "https://ichor.bio/veltuzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075735", "sequences": { "heavy_chain": "QVQLQQSGAEVKKPGSSVKVSCKASGYTFTSYNMHWVKQAPGQGLEWIGAIYPGMGDTSYNQKFKGKATLTADESTNTAYMELSSLRSEDTAFYYCARSTYYGGDWYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTMTCRASSSVSYIHWFQQKPGKAPKPWIYATSNLASGVPVRFSGSGSGTDYTFTISSLQPEDIATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0108", "inn": "Tovetumab", "target": "PDGFR alpha", "target_uniprot": "P16234", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5100", "product_url": "https://ichor.bio/tovetumab-biosimilar-research-grade", "rrid": "RRID:AB_3075736", "sequences": { "heavy_chain": "QVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMNWIRQAPGKGLEWVSYISSSGSIIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGRIAARGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVSITCRPSQSFSRYINWYQQKPGKAPKLLIHAASSLVGGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQTYSNPPITFGQGTRLEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.3, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0109", "inn": "Teplizumab", "target": "CD3E", "target_uniprot": "P07766", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(L234A/L235A/E356D/M358L)-Kappa", "product_sku": "ICH5101", "product_url": "https://ichor.bio/teplizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075737", "sequences": { "heavy_chain": "QVQLVQSGGGVVQPGRSLRLSCKASGYTFTRYTMHWVRQAPGKGLEWIGYINPSRGYTNYNQKVKDRFTISRDNSKNTAFLQMDSLRPEDTGVYFCARYYDDHYCLDYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCSASSSVSYMNWYQQTPGKAPKRWIYDTSKLASGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQWSSNPFTFGQGTKLQITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.56, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.291, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.291% main peak)" } ] }, { "entry_id": "ICB-BSR-0110", "inn": "Tanezumab", "target": "NGF", "target_uniprot": "P01138", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2(A330S/P331S)-Kappa", "product_sku": "ICH5102", "product_url": "https://ichor.bio/tanezumab-biosimilar-research-grade", "rrid": "RRID:AB_3075738", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLIGYDLNWIRQPPGKGLEWIGIIWGDGTTDYNSAVKSRVTISKDTSKNQFSLKLSSVTAADTAVYYCARGGYWYATSYYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISNNLNWYQQKPGKAPKLLIYYTSRFHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQEHTLPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0111", "inn": "Tabalumab", "target": "BAFF", "target_uniprot": "Q9Y275", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa(S70N)", "product_sku": "ICH5103", "product_url": "https://ichor.bio/tabalumab-biosimilar-research-grade", "rrid": "RRID:AB_3075739", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGYYDILTGYYYYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSRYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDSTLTISSLEPEDFAVYYCQQRSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSNTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0112", "inn": "Siltuximab", "target": "IL-6", "target_uniprot": "P05231", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5104", "product_url": "https://ichor.bio/siltuximab-biosimilar-research-grade", "rrid": "RRID:AB_3075744", "sequences": { "heavy_chain": "EVQLVESGGKLLKPGGSLKLSCAASGFTFSSFAMSWFRQSPEKRLEWVAEISSGGSYTYYPDTVTGRFTISRDNAKNTLYLEMSSLRSEDTAMYYCARGLWGYYALDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QIVLIQSPAIMSASPGEKVTMTCSASSSVSYMYWYQQKPGSSPRLLIYDTSNLASGVPVRFSGSGSGTSYSLTISRMEAEDAATYYCQQWSGYPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0113", "inn": "Sifalimumab", "target": "Interferon Alpha 1", "target_uniprot": "P0DY56", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Kappa", "product_sku": "ICH5105", "product_url": "https://ichor.bio/sifalimumab-biosimilar-research-grade", "rrid": "RRID:AB_3075745", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYSISWVRQAPGQGLEWMGWISVYNGNTNYAQKFQGRVTMTTDTSTSTAYLELRSLRSDDTAVYYCARDPIAAGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0114", "inn": "Satralizumab", "target": "IL-6R", "target_uniprot": "P08887", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2(C131S/R133K/E137G/C219S/H264Q/R351Q/S374A/Q415E/N430A)-Kappa", "product_sku": "ICH5106", "product_url": "https://ichor.bio/satralizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075746", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCAVSGHSISHDHAWSWVRQPPGEGLEWIGFISYSGITNYNPSLQGRVTISRDNSKNTLYLQMNSLRAEDTAVYYCARSLARTTAMDYWGEGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHAHYTQKSLSLSP", "light_chain": "DIQMTQSPSSLSASVGDSVTITCQASTDISSHLNWYQQKPGKAPELLIYYGSHLLSGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCGQGNRLPYTFGQGTKVEIERTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 5.92, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0115", "inn": "Sarilumab", "target": "IL-6R", "target_uniprot": "P08887", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5107", "product_url": "https://ichor.bio/sarilumab-biosimilar-research-grade", "rrid": "RRID:AB_3075747", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASRFTFDDYAMHWVRQAPGKGLEWVSGISWNSGRIGYADSVKGRFTISRDNAENSLFLQMNGLRAEDTALYYCAKGRDSFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYGASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFASYYCQQANSFPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.08, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0116", "inn": "Romosozumab", "target": "SOST", "target_uniprot": "Q9BQB4", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5108", "product_url": "https://ichor.bio/romosozumab-biosimilar-research-grade", "rrid": "RRID:AB_3075753", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGEINPNSGGAGYNQKFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARLGYDDIYDDWYFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGDTLPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.62, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.336, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.336% main peak)" } ] }, { "entry_id": "ICB-BSR-0117", "inn": "Robatumumab", "target": "IGF1R", "target_uniprot": "P06213;P08069", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5109", "product_url": "https://ichor.bio/robatumumab-biosimilar-research-grade-ich5109", "rrid": "RRID:AB_3075754", "sequences": { "heavy_chain": "EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSFAMHWVRQAPGKGLEWISVIDTRGATYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGNFYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSVSPGERATLSCRASQSIGSSLHWYQQKPGQAPRLLIKYASQSLSGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCHQSSRLPHTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.52, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0118", "inn": "Rilotumumab", "target": "HGF", "target_uniprot": "P14210", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5110", "product_url": "https://ichor.bio/rilotumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075755", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGGSISIYYWSWIRQPPGKGLEWIGYVYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLNSVTAADTAVYYCARGGYDFWSGYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVDSNLAWYRQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYINWPPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.87, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0119", "inn": "Ponezumab", "target": "APP", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2(A330S/P331S)-Kappa", "product_sku": "ICH5111", "product_url": "https://ichor.bio/ponezumab-biosimilar-research-grade-ich5111", "rrid": "RRID:AB_3075756", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYYTEAYYIHWVRQAPGQGLEWMGRIDPATGNTKYAPRLQDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCASLYSLPVYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSLLYSDAKTYLNWFQQRPGQSPRRLIYQISRLDPGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQGTHYPVLFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.04, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0120", "inn": "Penpulimab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(L234A/L235A/G237A/E356D/M358L)-Kappa", "product_sku": "ICH5112", "product_url": "https://ichor.bio/penpulimab-biosimilar-research-grade", "rrid": "RRID:AB_3075757", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFAFSSYDMSWVRQAPGKGLDWVATISGGGRYTYYPDSVKGRFTISRDNSKNNLYLQMNSLRAEDTALYYCANRYGEAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSMSASVGDRVTFTCRASQDINTYLSWFQQKPGKSPKTLIYRANRLVSGVPSRFSGSGSGQDYTLTISSLQPEDMATYYCLQYDEFPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0121", "inn": "Vudalimab", "target": "PD-1 + CTLA-4", "target_uniprot": "Q15116;P16410", "format": "Dual checkpoint inhibitor (NOT a T-cell engager) | Asymmetric — 1 Fab + 1 scFv, both monovalent | Fab (H+L) + scFv-Fc + heterodimeric Fc (3 chains)", "isotype": "IgG1 (Xencor XmAb Fc)", "product_sku": "ICH5113", "product_url": "https://ichor.bio/vudalimab-biosimilar-research-grade", "rrid": "RRID:AB_3075758", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVSFISYDGNNKYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVLHEALHSHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSASPGERVTLTCRASQSVGNDVAWYQQKPGQAPRLLINYASHRYTGVPDRFTGSGYGTEFTLTISSVQSEDFGVYYCQQDFSSPRTFGGGTKVEIKGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVKPGGSLRLSCVASGFTFSNYWMNWVRQAPGKGLEWVAEIRLYSNNYATHYAESVKGRFTISRDDSKSTLYLQMNNLKTEDTGVYYCTRYYGNYGGYFDVWGRGTLVTVSSEPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 125.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.5, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0122", "inn": "Farletuzumab", "target": "FOLR1", "target_uniprot": "P15328", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5114", "product_url": "https://ichor.bio/farletuzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075759", "sequences": { "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCSASGFTFSGYGLSWVRQAPGKGLEWVAMISSGGSYTYYADSVKGRFAISRDNAKNTLFLQMDSLRPEDTGVYFCARHGDDPAWFAYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCSVSSSISSNNLHWYQQKPGKAPKPWIYGTSNLASGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQWSSYPYMYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.276, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.276% main peak)" } ] }, { "entry_id": "ICB-BSR-0123", "inn": "Canakinumab", "target": "IL1B", "target_uniprot": "P01584", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5115", "product_url": "https://ichor.bio/canakinumab-biosimilar-research-grade", "rrid": "RRID:AB_3075760", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSVYGMNWVRQAPGKGLEWVAIIWYDGDNQYYADSVKGRFTISRDNSKNTLYLQMNGLRAEDTAVYYCARDLRTGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPDFQSVTPKEKVTITCRASQSIGSSLHWYQQKPDQSPKLLIKYASQSFSGVPSRFSGSGSGTDFTLTINSLEAEDAAAYYCHQSSSLPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.746, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.746% main peak)" } ] }, { "entry_id": "ICB-BSR-0124", "inn": "Relatlimab", "target": "LAG3", "target_uniprot": "P18627", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5117", "product_url": "https://ichor.bio/relatlimab-biosimilar-research-grade", "rrid": "RRID:AB_3075762", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSDYYWNWIRQPPGKGLEWIGEINHRGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYEYNWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSISSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGQGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.59, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0125", "inn": "Ivuxolimab", "target": "OX40", "target_uniprot": "P43489", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5119", "product_url": "https://ichor.bio/ivuxolimab-biosimilar-research-grade", "rrid": "RRID:AB_3075764", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSYISSSSSTIDYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARESGWYLFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.81, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.297, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.297% main peak)" } ] }, { "entry_id": "ICB-BSR-0126", "inn": "Necitumumab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(F126L/K214R)-Kappa", "product_sku": "ICH5121", "product_url": "https://ichor.bio/necitumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075766", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGDYYWSWIRQPPGKGLEWIGYIYYSGSTDYNPSLKSRVTMSVDTSKNQFSLKVNSVTAADTAVYYCARVSIFGVGTFDYWGQGTLVTVSSASTKGPSVLPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHQYGSTPLTFGGGTKAEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0127", "inn": "Tilvestamab", "target": "Axl", "target_uniprot": "P30530", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Kappa", "product_sku": "ICH5122", "product_url": "https://ichor.bio/tilvestamab-biosimilar-research-grade", "rrid": "RRID:AB_3075767", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSFTDFYINWVRQAPGKGLEWVARIFPGGDNTYYNEKFKGRFTLSADTSKSTAYLQMNSLRAEDTAVYYCARRGLYYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGIPYLHWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCSQGTHVPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.5, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0128", "inn": "Nemolizumab", "target": "IL-31RA", "target_uniprot": "Q8NI17", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2(C130S/R132K/E136G/S137G/C218S/H263Q/R350Q/Q414E/G441DEL/K442DEL)-Kappa", "product_sku": "ICH5123", "product_url": "https://ichor.bio/nemolizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075768", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYIMNWVRQAPGQGLEWMGLINPYNGGTDYNPQFQDRVTITADKSTSTAYMELSSLRSEDTAVYYCARDGYDDGPYTLETWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSP", "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASEDIYSFVAWYQQKPGKAPKLLIYNAQTEAQGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYDSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 5.86, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0129", "inn": "Enoblituzumab", "target": "CD276", "target_uniprot": "Q5ZPR3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R/L235V/ F243L/R292P/Y300L/P396L)-Kappa", "product_sku": "ICH5124", "product_url": "https://ichor.bio/enoblituzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075769", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAYISSDSSAIYYADTVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCGRGRENIYYGSRLDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELVGGPSVFLLPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPPEEQYNSTLRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPLVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSFLSASVGDRVTITCKASQNVDTNVAWYQQKPGKAPKALIYSASYRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.025, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.025% main peak)" } ] }, { "entry_id": "ICB-BSR-0130", "inn": "Tilavonemab", "target": "Tau", "target_uniprot": "P10636", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5125", "product_url": "https://ichor.bio/tilavonemab-biosimilar-research-grade-ich5125", "rrid": "RRID:AB_3075770", "sequences": { "heavy_chain": "EVKVVESGGGLVQPGGSMKLSCVVSGFTFSNYWVNWVRQAPGKGLEWVAQIRLKSDNYATHYEESVKGRFTISRDDSKSSVYLQMNNLRAEDSGIYYCTNWEDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVLTQSPDSLAVSLGERATISCRASQSVSTSRYSYIHWYQQKPGQPPKLLIKYASNLESGVPSRFSGSGSGTDFTLNIHPLEPEDFATYYCHHSWEIPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.56, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95.203, "unit": "%", "method": "SEC-HPLC (supplier CoA, 95.203% main peak)" } ] }, { "entry_id": "ICB-BSR-0131", "inn": "Zagotenemab", "target": "Tau", "target_uniprot": "P10636", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P/F234A/L235A/K447Del)-Kappa", "product_sku": "ICH5126", "product_url": "https://ichor.bio/zagotenemab-biosimilar-research-grade-ich5126", "rrid": "RRID:AB_3075771", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYTFSNYWIEWVRQMPGKGLEWMGEILPGSDSIKYEKNFKGQVTISADKSISTAYLQWSSLKASDTAMYYCARRGNYVDDWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRSSQSLVHSNQNTYLHWYQQKPGQAPRLLIYKVDNRFSGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCSQSTLVPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.11, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0132", "inn": "Teprotumumab", "target": "IGF1R", "target_uniprot": "P06213;P08069", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5128", "product_url": "https://ichor.bio/teprotumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075773", "sequences": { "heavy_chain": "QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKWPPWTFGQGTKVESKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.6, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0133", "inn": "Lucatumumab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(S131A/K214R)-Kappa", "product_sku": "ICH5129", "product_url": "https://ichor.bio/lucatumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075774", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYEESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIAAPGPDYWGQGTLVTVSSASTKGPSVFPLAPASKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSLTVTPGEPASISCRSSQSLLYSNGYNYLDWYLQKPGQSPQVLISLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQARQTPFTFGPGTKVDIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.08, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0134", "inn": "Anifrolumab", "target": "IFNAR1", "target_uniprot": "P17181", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R/L351F/L352E/P448S)-Kappa", "product_sku": "ICH5130", "product_url": "https://ichor.bio/anifrolumab-biosimilar-research-grade", "rrid": "RRID:AB_3075775", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYIFTNYWIAWVRQMPGKGLESMGIIYPGDSDIRYSPSFQGQVTISADKSITTAYLQWSSLKASDTAMYYCARHDIEGFDYWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSFFAWYQQKPGQAPRLLIYGASSRATGIPDRLSGSGSGTDFTLTITRLEPEDFAVYYCQQYDSSAITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0135", "inn": "Uliledlimab", "target": "NT5E", "target_uniprot": "P21589", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(N297A)-Kappa", "product_sku": "ICH5131", "product_url": "https://ichor.bio/uliledlimab-biosimilar-research-grade", "rrid": "RRID:AB_3075776", "sequences": { "heavy_chain": "EVQLQESGPGLVKPSETLSLTCAVSGYSITSGYYWNWIRQPPGKKLEWMGYINYGGSNGYNPSLKSRITISRDTSKNQFSLKLSSVTAADTAVYYCARDYDAYYEALDDWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLSQSPATLSLSPGERATLSCRASSRVNYMHWYQQKPGQSPRPWISATSNLASGVPARFSGSGSGTSYTLTISSLEPEDFAVYYCQQWSSNPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0136", "inn": "Tafasitamab", "target": "CD19", "target_uniprot": "P15391;P51677", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(S239D/K274Q/Y296F/Y300F/L309V/I332E/A339T/V397M)-Kappa", "product_sku": "ICH5132", "product_url": "https://ichor.bio/tafasitamab-biosimilar-research-grade", "rrid": "RRID:AB_3075777", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKYNEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKALPAPEEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLNSGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.14, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0137", "inn": "Gevokizumab", "target": "IL-1B", "target_uniprot": "P01584", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5133", "product_url": "https://ichor.bio/gevokizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075778", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDGDESYNPSLKSRLTISKDTSKNQVSLKITSVTAADTAVYFCARNRYDPPWFVDWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVTSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGMEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSTSSLSASVGDRVTITCRASQDISNYLSWYQQKPGKAVKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQQEDFATYFCLQGKMLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.88, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.435, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.435% main peak)" } ] }, { "entry_id": "ICB-BSR-0138", "inn": "Enibarcimab", "target": "ADM", "target_uniprot": "P35318", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5134", "product_url": "https://ichor.bio/enibarcimab-biosimilar-research-grade", "rrid": "RRID:AB_3075779", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFSRYWIEWVRQAPGQGLEWIGEILPGSGSTNYNQKFQGRVTITADTSTSTAYMELSSLRSEDTAVYYCTEGYEYDGFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVLTQSPLSLPVTLGQPASISCRSSQSIVYSNGNTYLEWYLQRPGQSPRLLIYRVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0139", "inn": "Mupadolimab", "target": "CD73", "target_uniprot": "P21589", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(N297Q/E356D/M358L)-Kappa", "product_sku": "ICH5136", "product_url": "https://ichor.bio/mupadolimab-biosimilar-research-grade", "rrid": "RRID:AB_3075780", "sequences": { "heavy_chain": "QVQLVQSGAEVEKPGASVKVSCKASGYTFTSYWITWVRQAPGQGLEWMGDIYPGSGNTNYNEKFKTRVTITADKSTSTAYMELSSLRSEDTAVYYCAKEGGLTTEDYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASKNVSTSGYSYMHWYQQKPGQAPRLLIYLASNLESGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCQHSRELPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.14, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0140", "inn": "Brentuximab Vedotin", "target": "TNFRSF8 / CD30", "target_uniprot": "P28908", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5137V", "product_url": "https://ichor.bio/brentuximab-vedotin-biosimilar-research-grade-ich5137v", "rrid": "", "sequences": { "heavy_chain": "QIQLQQSGPEVVKPGASVKISCKASGYTFTDYYITWVKQKPGQGLEWIGWIYPGSGNTKYNEKFKGKATLTVDTSSSTAFMQLSSLTSEDTAVYFCANYGNYWFAYWGQGTQVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVLTQSPASLAVSLGQRATISCKASQSVDFDGDSYMNWYQQKPGQPPKVLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.66, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0141", "inn": "Abituzumab", "target": "CD51", "target_uniprot": "P06756", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5138", "product_url": "https://ichor.bio/abituzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075782", "sequences": { "heavy_chain": "QVQLQQSGGELAKPGASVKVSCKASGYTFSSFWMHWVRQAPGQGLEWIGYINPRSGYTEYNEIFRDKATMTTDTSTSTAYMELSSLRSEDTAVYYCASFLGRGAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVEPKSSDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQAQSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLAWYQQKPGKAPKLLIYYTSKIHSGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQGNTFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0142", "inn": "Abrilumab", "target": "ITGA4 + ITGB7", "target_uniprot": "P13612;P26010", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5139", "product_url": "https://ichor.bio/abrilumab-biosimilar-research-grade", "rrid": "RRID:AB_3075783", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGYTLSDLSIHWVRQAPGKGLEWMGGFDPQDGETIYAQKFQGRVTMTEDTSTDTAYMELSSLKSEDTAVYYCATGSSSSWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYGASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFANYYCQQANSFPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.45, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0143", "inn": "Bapineuzumab", "target": "APP", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Kappa", "product_sku": "ICH5140", "product_url": "https://ichor.bio/bapineuzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075784", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNKYTQKSLSLSPG", "light_chain": "DVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0144", "inn": "Blosozumab", "target": "SOST", "target_uniprot": "Q9BQB4", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P/KDel)-Kappa", "product_sku": "ICH5141", "product_url": "https://ichor.bio/blosozumab-biosimilar-research-grade", "rrid": "RRID:AB_3075785", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGFPIKDTFQHWVRQAPGKGLEWMGWSDPEIGDTEYASKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCATGDTTYKFDFWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVHTAVAWYQQKPGKAPKLLIYWASTRWTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSDYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.18, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0145", "inn": "Bococizumab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2(A330S/P331S)-Kappa", "product_sku": "ICH5142", "product_url": "https://ichor.bio/bococizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075786", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGEISPFGGRTNYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARERPLYASDLWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQRYSLWRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.47, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.526, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.526% main peak)" } ] }, { "entry_id": "ICB-BSR-0146", "inn": "Carlumab", "target": "CCL2", "target_uniprot": "P13500", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5143", "product_url": "https://ichor.bio/carlumab-biosimilar-research-grade", "rrid": "RRID:AB_3075787", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYGISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDGIYGELDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSDAYLAWYQQKPGQAPRLLIYDASSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCHQYIQLHSFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0147", "inn": "Cixutumumab", "target": "IGF1R", "target_uniprot": "P06213;P08069", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Kappa", "product_sku": "ICH5144", "product_url": "https://ichor.bio/cixutumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075788", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARAPLRFLEWSTQDHYYYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "SSELTQDPAVSVALGQTVRITCQGDSLRSYYATWYQQKPGQAPILVIYGENKRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCKSRDGSGQHLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPAECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95.668, "unit": "%", "method": "SEC-HPLC (supplier CoA, 95.668% main peak)" } ] }, { "entry_id": "ICB-BSR-0148", "inn": "Efalizumab", "target": "CD11a", "target_uniprot": "P20701", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Kappa", "product_sku": "ICH5145", "product_url": "https://ichor.bio/efalizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075789", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYSFTGHWMNWVRQAPGKGLEWVGMIHPSDSETRYNQKFKDRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARGIYFYGTTYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASKTISKYLAWYQQKPGKAPKLLIYSGSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHNEYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0149", "inn": "Eldelumab", "target": "CXCL10", "target_uniprot": "P02778", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5146", "product_url": "https://ichor.bio/eldelumab-biosimilar-research-grade", "rrid": "RRID:AB_3075790", "sequences": { "heavy_chain": "QMQLVESGGGVVQPGRSLRLSCTASGFTFSNNGMHWVRQAPGKGLEWVAVIWFDGMNKFYVDSVKGRFTISRDNSKNTLYLEMNSLRAEDTAIYYCAREGDGSGIYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPIFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0150", "inn": "Emapalumab", "target": "IFN-gamma", "target_uniprot": "P01579", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5147", "product_url": "https://ichor.bio/emapalumab-biosimilar-research-grade", "rrid": "RRID:AB_3075791", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDGSSGWYVPHWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDGSNRWMFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0151", "inn": "Emibetuzumab", "target": "MET", "target_uniprot": "P08581", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P/F234A/L235A/KDel)-Kappa", "product_sku": "ICH5148", "product_url": "https://ichor.bio/emibetuzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075792", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYYMHWVRQAPGQGLEWMGRVNPNRRGTTYNQKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARANWLDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCSVSSSVSSIYLHWYQQKPGKAPKLLIYSTSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQVYSGYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0152", "inn": "Enokizumab", "target": "IL-9", "target_uniprot": "P15248", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5149", "product_url": "https://ichor.bio/enokizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075793", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSYYWIEWVRQAPGQGLEWMGEILPGSGTTNPNEKFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARADYYGSDYVKFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQHVITHVTWYQQKPGKAPKLLIYGTSYSYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFYEYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0153", "inn": "Etrolizumab", "target": "ITGA4 + ITGB7", "target_uniprot": "P13612;P26010", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(KDel)-Kappa", "product_sku": "ICH5150", "product_url": "https://ichor.bio/etrolizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075794", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFFITNNYWGWVRQAPGKGLEWVGYISYSGSTSYNPSLKSRFTISRDTSKNTFYLQMNSLRAEDTAVYYCARTGSSGYFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASESVDDLLHWYQQKPGKAPKLLIKYASQSISGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGNSLPNTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0154", "inn": "Evinacumab", "target": "ANGPTL3", "target_uniprot": "Q9Y5C1", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5151", "product_url": "https://ichor.bio/evinacumab-biosimilar-research-grade", "rrid": "RRID:AB_3075795", "sequences": { "heavy_chain": "EVQLVESGGGVIQPGGSLRLSCAASGFTFDDYAMNWVRQGPGKGLEWVSAISGDGGSTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAFFYCAKDLRNTIFGVVIPDAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQSIRSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNSYSYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.78, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0155", "inn": "Fasinumab", "target": "NGF", "target_uniprot": "P01138", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5152", "product_url": "https://ichor.bio/fasinumab-biosimilar-research-grade", "rrid": "RRID:AB_3075796", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGFTLTELSIHWVRQAPGKGLEWMGGFDPEDGETIYAQKFQGRVTMTEDTSTDTAYMELTSLRSEDTAVYYCSTIFGVVTNFDNWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASAGDRVTITCRASQAIRNDLGWYQQKPGKAPKRLIYAAFNLQSGVPSRFSGSGSGTEFTLTISSLQPEDLASYYCQQYNRYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.59, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0156", "inn": "Ficlatuzumab", "target": "HGF", "target_uniprot": "P14210", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5153", "product_url": "https://ichor.bio/ficlatuzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075797", "sequences": { "heavy_chain": "QVQLVQPGAEVKKPGTSVKLSCKASGYTFTTYWMHWVRQAPGQGLEWIGEINPTNGHTNYNQKFQGRATLTVDKSTSTAYMELSSLRSEDTAVYYCARNYVGSIFDYWGQGTLLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAMSLGERVTLNCKASENVVSYVSWYQQKPGQSPKLLIYGASNRESGVPDRFSGSGSATDFTLTISSVQAEDVADYHCGQSYNYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0157", "inn": "Figitumumab", "target": "IGF1R", "target_uniprot": "P06213;P08069", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2(KDel)-Kappa", "product_sku": "ICH5154", "product_url": "https://ichor.bio/figitumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075798", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCTASGFTFSSYAMNWVRQAPGKGLEWVSAISGSGGTTFYADSVKGRFTISRDNSRTTLYLQMNSLRAEDTAVYYCAKDLGWSDSYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQFPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASRLHRGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYPCSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.86, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0158", "inn": "Fletikumab", "target": "IL-20", "target_uniprot": "Q9NYY1;Q9UHF5;Q6UXL0", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5155", "product_url": "https://ichor.bio/fletikumab-biosimilar-research-grade", "rrid": "RRID:AB_3075799", "sequences": { "heavy_chain": "QVQLVQSGAEVKRPGASVKVSCKASGYTFTNDIIHWVRQAPGQRLEWMGWINAGYGNTQYSQNFQDRVSITRDTSASTAYMELISLRSEDTAVYYCAREPLWFGESSPHDYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.63, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0159", "inn": "Foralumab", "target": "CD3E", "target_uniprot": "P07766", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Kappa", "product_sku": "ICH5156", "product_url": "https://ichor.bio/foralumab-biosimilar-research-grade", "rrid": "RRID:AB_3075800", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFKFSGYGMHWVRQAPGKGLEWVAVIWYDGSKKYYVDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQMGYWHFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.59, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.506, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.506% main peak)" } ] }, { "entry_id": "ICB-BSR-0160", "inn": "Fulranumab", "target": "NGF", "target_uniprot": "P01138", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5157", "product_url": "https://ichor.bio/fulranumab-biosimilar-research-grade", "rrid": "RRID:AB_3075801", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTLRSYSMNWVRQAPGKGLEWVSYISRSSHTIFYADSVKGRFTISRDNAKNSLYLQMDSLRDEDTAMYYCARVYSSGWHVSDYFDYWGQGILVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0161", "inn": "Zilovertamab", "target": "ROR1", "target_uniprot": "Q01973", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5158", "product_url": "https://ichor.bio/zilovertamab-biosimilar-research-grade", "rrid": "RRID:AB_3075802", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGYAFTAYNIHWVRQAPGQGLEWMGSFDPYDGGSSYNQKFKDRLTISKDTSKNQVVLTMTNMDPVDTATYYCARGWYYFDYWGHGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQTPLSLPVTPGEPASISCRASKSISKYLAWYQQKPGQAPRLLIYSGSTLQSGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCQQHDESPYTFGEGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.16, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.258, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.258% main peak)" } ] }, { "entry_id": "ICB-BSR-0162", "inn": "Vibostolimab", "target": "TIGIT", "target_uniprot": "Q495A1", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5159", "product_url": "https://ichor.bio/vibostolimab-biosimilar-research-grade", "rrid": "RRID:AB_3075803", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGYTFSSYVMHWVRQAPGQGLEWIGYIDPYNDGAKYAQKFQGRVTLTSDKSTSTAYMELSSLRSEDTAVYYCARGGPYGWYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASEHIYSYLSWYQQKPGKVPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQHHFGSPLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0163", "inn": "Burosumab", "target": "FGF23", "target_uniprot": "Q9GZV9", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5160", "product_url": "https://ichor.bio/burosumab-biosimilar-research-grade", "rrid": "RRID:AB_3075804", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHYMHWVRQAPGQGLEWMGIINPISGSTSNAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARDIVDAFDFWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALVWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNDYFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0164", "inn": "Cemiplimab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5161", "product_url": "https://ichor.bio/cemiplimab-biosimilar-research-grade", "rrid": "RRID:AB_3075805", "sequences": { "heavy_chain": "EVQLLESGGVLVQPGGSLRLSCAASGFTFSNFGMTWVRQAPGKGLEWVSGISGGGRDTYFADSVKGRFTISRDNSKNTLYLQMNSLKGEDTAVYYCVKWGNIYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDSITITCRASLSINTFLNWYQQKPGKAPNLLIYAASSLHGGVPSRFSGSGSGTDFTLTIRTLQPEDFATYYCQQSSNTPFTFGPGTVVDFRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.09, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.061, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.061% main peak)" } ] }, { "entry_id": "ICB-BSR-0165", "inn": "Glembatumumab", "target": "GPNMB", "target_uniprot": "Q14956", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5163", "product_url": "https://ichor.bio/glembatumumab-biosimilar-research-grade", "rrid": "RRID:AB_3075806", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSFNYYWSWIRHHPGKGLEWIGYIYYSGSTYSNPSLKSRVTISVDTSKNQFSLTLSSVTAADTAVYYCARGYNWNYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVDNNLVWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.87, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0166", "inn": "Naxitamab", "target": "Ganglioside GD2", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R/E356D/M358L)-Kappa", "product_sku": "ICH5164", "product_url": "https://ichor.bio/naxitamab-biosimilar-research-grade", "rrid": "RRID:AB_3075807", "sequences": { "heavy_chain": "QVQLVESGPGVVQPGRSLRISCAVSGFSVTNYGVHWVRQPPGKGLEWLGVIWAGGITNYNSAFMSRLTISKDNSKNTVYLQMNSLRAEDTAMYYCASRGGHYGYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQTPATLSVSAGERVTITCKASQSVSNDVTWYQQKPGQAPRLLIYSASNRYSGVPARFSGSGYGTEFTFTISSVQSEDFAVYFCQQDYSSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 96.588, "unit": "%", "method": "SEC-HPLC (supplier CoA, 96.588% main peak)" } ] }, { "entry_id": "ICB-BSR-0167", "inn": "Ixekizumab", "target": "IL-17A", "target_uniprot": "Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5165", "product_url": "https://ichor.bio/ixekizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075808", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYSFTDYHIHWVRQAPGQGLEWMGVINPMYGTTDYNQRFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDYFTGTGVYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSRSLVHSRGNTYLHWYLQKPGQSPQLLIYKVSNRFIGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHLPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.69, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.167, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.167% main peak)" } ] }, { "entry_id": "ICB-BSR-0168", "inn": "Lenzilumab", "target": "CSF2", "target_uniprot": "P04141", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5166", "product_url": "https://ichor.bio/lenzilumab-biosimilar-research-grade", "rrid": "RRID:AB_3075809", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYSFTNYYIHWVRQAPGQRLEWMGWINAGNGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCVRRQRFPYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSVSPGERATLSCRASQSVGTNVAWYQQKPGQAPRVLIYSTSSRATGITDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFNKSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.77, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0169", "inn": "Lirilumab", "target": "KIR2DL1", "target_uniprot": "P43626;Q14953;Q14954", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5167", "product_url": "https://ichor.bio/lirilumab-biosimilar-research-grade", "rrid": "RRID:AB_3075810", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSFYAISWVRQAPGQGLEWMGGFIPIFGAANYAQKFQGRVTITADESTSTAYMELSSLRSDDTAVYYCARIPSGSYYYDYDMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPVTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.78, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0170", "inn": "Inebilizumab", "target": "CD19", "target_uniprot": "P15391;P51677", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5168", "product_url": "https://ichor.bio/inebilizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075811", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSWMNWVRQAPGKGLEWVGRIYPGDGDTNYNVKFKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARSGFITTVRDFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPDFQSVTPKEKVTITCRASESVDTFGISFMNWFQQKPDQSPKLLIHEASNQGSGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQSKEVPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.13, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.359, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.359% main peak)" } ] }, { "entry_id": "ICB-BSR-0171", "inn": "Motavizumab", "target": "RSV", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5169", "product_url": "https://ichor.bio/motavizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075812", "sequences": { "heavy_chain": "QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0172", "inn": "Olokizumab", "target": "IL-6", "target_uniprot": "P05231", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P)-Kappa", "product_sku": "ICH5170", "product_url": "https://ichor.bio/olokizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075813", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNFNDYFMNWVRQAPGKGLEWVAQMRNKNYQYGTYYAESLEGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARESYYGFTSYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDIGISLSWYQQKPGKAPKLLIYNANNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQHNSAPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0173", "inn": "Otelixizumab", "target": "CD3E", "target_uniprot": "P07766", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(N297A/E356D/M358L)-Lambda2(K83R)", "product_sku": "ICH5171", "product_url": "https://ichor.bio/otelixizumab-biosimilar-research-grade-ich5171", "rrid": "RRID:AB_3075814", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSFPMAWVRQAPGKGLEWVSTISTSGGRTYYRDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKFRQYSGGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQPNSVSTSLGSTVKLSCTLSSGNIENNYVHWYQLYEGRSPTTMIYDDDKRPDGVPDRFSGSIDRSSNSAFLTIHNVAIEDEAIYFCHSYVSSFNVFGGGTKLTVLRQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0174", "inn": "Ozanezumab", "target": "NOGO-A", "target_uniprot": "Q9NQC3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(L235A/G237A/E356D/M358L)-Kappa", "product_sku": "ICH5173", "product_url": "https://ichor.bio/ozanezumab-biosimilar-research-grade", "rrid": "RRID:AB_3075816", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWMHWVRQAPGQGLEWIGNINPSNGGTNYNEKFKSKATMTRDTSTSTAYMELSSLRSEDTAVYYCELMQGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSNPVTLGQPVSISCRSSKSLLYKDGKTYLNWFLQRPGQSPQLLIYLMSTRASGVPDRFSGGGSGTDFTLKISRVEAEDVGVYYCQQLVEYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0175", "inn": "Panobacumab", "target": "Pseudomonas aeruginosa serotype IATS O11", "target_uniprot": null, "format": "IgM (pentamer; 5x[2H+2L]+J-chain, theoretical)", "isotype": "IgM-Kappa", "product_sku": "ICH5174", "product_url": "https://ichor.bio/panobacumab-biosimilar-research-grade-ich5174", "rrid": "RRID:AB_3075817", "sequences": { "heavy_chain": "EEQVVESGGGFVQPGGSLRLSCAASGFTFSPYWMHWVRQAPGKGLVWVSRINSDGSTYYADSVKGRFTISRDNARNTLYLQMNSLRAEDTAVYYCARDRYYGPEMWGQGTMVTVSSGSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITFSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLSQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY", "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNRDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 864.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0176", "inn": "Parsatuzumab", "target": "EGFL7", "target_uniprot": "Q9UHF1", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1-Kappa", "product_sku": "ICH5175", "product_url": "https://ichor.bio/parsatuzumab-biosimilar-research-grade-ich5175", "rrid": "RRID:AB_3075818", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFIDYYMNWVRQAPGKGLEWVGDINLDNSGTHYNQKFKGRFTISRDKSKNTAYLQMNSLRAEDTAVYYCAREGVYHDYDDYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSQSLVHINAITYLHWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCGQSTHVPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0177", "inn": "Fezakinumab", "target": "IL-22", "target_uniprot": "Q9GZX6;Q8N6P7;Q969J5", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(KDel)- Lambda 2(K83R)", "product_sku": "ICH5176", "product_url": "https://ichor.bio/fezakinumab-biosimilar-research-grade-ich5176", "rrid": "RRID:AB_3075819", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMHWVRQAPGQGLEWVGWINPYTGSAFYAQKFRGRVTMTRDTSISTAYMELSRLRSDDTAVYYCAREPEKFDSDDSDVWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QAVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYGVHWYQQLPGTAPKLLIYGDSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDNSLSGYVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.806, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.806% main peak)" } ] }, { "entry_id": "ICB-BSR-0178", "inn": "Emicizumab", "target": "Factor IX + Factor X", "target_uniprot": "P00740;P00742", "format": "bispecific / multi-chain (4 chains)", "isotype": "IgG4 mutation-kappa", "product_sku": "ICH5178", "product_url": "https://ichor.bio/emicizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075821", "sequences": { "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFSYYDIQWVRQAPGKGLEWVSSISPSGQSTYYRREVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRTGREYGGGWYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQKEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNRYTQKSLSLSP", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASRNIERQLAWYQQKPGQAPELLIYQASRKESGVPDRFSGSRYGTDFTLTISSLQPEDIATYYCQQYSDPPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.46, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.318, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.318% main peak)" } ] }, { "entry_id": "ICB-BSR-0179", "inn": "Ozuriftamab", "target": "ROR2", "target_uniprot": "Q01974", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L/KDel)-Kappa", "product_sku": "ICH5179", "product_url": "https://ichor.bio/ozuriftamab-biosimilar-research-grade", "rrid": "RRID:AB_3075822", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLRISCKGSGYTFTEYTMHWVRQAPGQGLEWMGGINTNNGGTGYNQKFKGRVTISADKSISTAYLQWSSLKASDTAMYYCAHGSLYSYGNSYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "AIQLTQSPSSLSASVGDRVTITCSATSSVSYMHWYLQKPGQSPQLLIYGTSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQRSSYPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0180", "inn": "Bamlanivimab", "target": "SARS-CoV-2", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(K214R)-Kappa", "product_sku": "ICH5180", "product_url": "https://ichor.bio/bamlanivimab-biosimilar-research-grade", "rrid": "RRID:AB_3075823", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNYAISWVRQAPGQGLEWMGRIIPILGIANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGYYEARHYYYYYAMDVWGQGTAVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSYLSWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTITSLQPEDFATYYCQQSYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.64, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0181", "inn": "Ponsegromab", "target": "GDF15", "target_uniprot": "Q99988", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(L234A/L235A/G237A/KDel)-Kappa", "product_sku": "ICH5182", "product_url": "https://ichor.bio/ponsegromab-biosimilar-research-grade", "rrid": "RRID:AB_3075825", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFSSYNIDWVRQAPGQGLEWMGGINPIFGTAFYNQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCAREAITTVGAMDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPATLSLSPGERATLSCRTSQSVHNYLAWYQQKPGQAPRLLIYDASTRADGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQFWSWPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.14, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0182", "inn": "Lusvertikimab", "target": "IL-7RA", "target_uniprot": "P16871", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4(S228P/L445P)-Kappa", "product_sku": "ICH5183", "product_url": "https://ichor.bio/lusvertikimab-biosimilar-research-grade", "rrid": "RRID:AB_3075826", "sequences": { "heavy_chain": "QVQLVESGGGLVKPGGSLRLSCAVSGFTLSDYYMAWIRQAPGKGLEWVSTISASGLRTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARPLSAHYGFNYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSEDIYQGLAWYQQKPGKAPKLLLYSANTLHIGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYYDYPLAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0183", "inn": "Tremelimumab", "target": "CTLA-4", "target_uniprot": "P16410", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 kappa", "product_sku": "ICH5184", "product_url": "https://ichor.bio/tremelimumab-biosimilar-research-grade", "rrid": "RRID:AB_3075827", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDPRGATLYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSINSYLDWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.04, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0184", "inn": "Mogamulizumab", "target": "CCR4", "target_uniprot": "Q9UK39;Q9ULM6;P51679", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1κ", "product_sku": "ICH5186", "product_url": "https://ichor.bio/mogamulizumab-biosimilar-research-grade", "rrid": "RRID:AB_3075829", "sequences": { "heavy_chain": "EVQLVESGGDLVQPGRSLRLSCAASGFIFSNYGMSWVRQAPGKGLEWVATISSASTYSYYPDSVKGRFTISRDNAKNSLYLQMNSLRVEDTALYYCGRHSDGNFAFGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVLMTQSPLSLPVTPGEPASISCRSSRNIVHINGDTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSLLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0185", "inn": "Oxelumab", "target": "CD37", "target_uniprot": "P11049", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1CH2+CH3(E356D/M358L)-Kappa", "product_sku": "ICH5187", "product_url": "https://ichor.bio/oxelumab-biosimilar-research-grade-ich5187", "rrid": "RRID:AB_3075832", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFNSYAMSWVRQAPGKGLEWVSIISGSGGFTYYADSVKGRFTISRDNSRTTLYLQMNSLRAEDTAVYYCAKDRLVAPGTFDYWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0186", "inn": "Briakinumab", "target": "CD30", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5188", "product_url": "https://ichor.bio/briakinumab-biosimilar-research-grade-1", "rrid": "RRID:AB_3075835", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIRYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCKTHGSHDNWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSVSGAPGQRVTISCSGSRSNIGSNTVKWYQQLPGTAPKLLIYYNDQRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDRYTHPALLFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0187", "inn": "Elotuzumab", "target": "SLAMF7", "target_uniprot": "Q9NQ25", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5202", "product_url": "https://ichor.bio/elotuzumab-biosimilar-research-grade-ich5202", "rrid": "RRID:AB_3075852", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFDFSRYWMSWVRQAPGKGLEWIGEINPDSSTINYAPSLKDKFIISRDNAKNSLYLQMNSLRAEDTAVYYCARPDGNYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVGIAVAWYQQKPGKVPKLLIYWASTRHTGVPDRFSGSGSGTDFTLTISSLQPEDVATYYCQQYSSYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.115, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.115% main peak)" } ] }, { "entry_id": "ICB-BSR-0188", "inn": "Patritumab", "target": "HER3", "target_uniprot": "P21860", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5206", "product_url": "https://ichor.bio/patritumab-biosimilar-research-grade-ich5206", "rrid": "RRID:AB_3075856", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWTWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIEMTQSPDSLAVSLGERATINCRSSQSVLYSSSNRNYLAWYQQNPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0189", "inn": "Patritumab Deruxtecan", "target": "ERBB3 / HER3", "target_uniprot": "P21860", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5206D", "product_url": "https://ichor.bio/patritumab-deruxtecan-biosimilar-research-grade-ich5206d", "rrid": "", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWTWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIEMTQSPDSLAVSLGERATINCRSSQSVLYSSSNRNYLAWYQQNPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0190", "inn": "Talquetamab", "target": "CD3 + GPRC5D", "target_uniprot": "P07766;Q9NZD1", "format": "bispecific / multi-chain (4 chains)", "isotype": "N/A", "product_sku": "ICH5207", "product_url": "https://ichor.bio/talquetamab-biosimilar-research-grade-ich5207", "rrid": "RRID:AB_3075857", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARHGNFGNSYVSWFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "QTVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.47, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0191", "inn": "Teclistamab", "target": "CD3 + BCMA", "target_uniprot": "P07766;Q02223", "format": "bispecific / multi-chain (4 chains)", "isotype": "IgG4 - lambda", "product_sku": "ICH5209", "product_url": "https://ichor.bio/teclistamab-biosimilar-research-grade", "rrid": "RRID:AB_3075859", "sequences": { "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSISSGSYFWGWIRQPPGKGLEWIGSIYYSGITYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARHDGAVAGLFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQPPGQAPVVVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEAVYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKGDSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.14, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.14% main peak)" } ] }, { "entry_id": "ICB-BSR-0192", "inn": "Risankizumab", "target": "IL-23α", "target_uniprot": "Q9NPF7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5210", "product_url": "https://ichor.bio/risankizumab-biosimilar-research-grade-ich5210", "rrid": "RRID:AB_3075860", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDQTIHWMRQAPGQGLEWIGYIYPRDDSPKYNENFKGKVTITADKSTSTAYMELSSLRSEDTAVYYCAIPDRSGYAWFIYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASRDVAIAVAWYQQKPGKVPKLLIYWASTRHTGVPSRFSGSGSRTDFTLTISSLQPEDVADYFCHQYSSYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0193", "inn": "Onartuzumab", "target": "MET", "target_uniprot": "P08581", "format": "Fab fragment (1 H-fragment + 1 L)", "isotype": "(Fab - G1 - kappa) - (Fc - G1)", "product_sku": "ICH5212", "product_url": "https://ichor.bio/onartuzumab-biosimilar-research-grade", "rrid": "RRID:AB_3075862", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYWLHWVRQAPGKGLEWVGMIDPSNSDTRFNPNFKDRFTISADTSKNTAYLQMNSLRAEDTAVYYCATYRSYVTPLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKSSQSLLYTSSQKNYLAWYQQKPGKAPKLLIYWASTRESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYAYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 73.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0194", "inn": "Tezepelumab", "target": "TSLP", "target_uniprot": "Q969D9", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5213", "product_url": "https://ichor.bio/tezepelumab-biosimilar-research-grade", "rrid": "RRID:AB_3075863", "sequences": { "heavy_chain": "QMQLVESGGGVVQPGRSLRLSCAASGFTFRTYGMHWVRQAPGKGLEWVAVIWYDGSNKHYADSVKGRFTITRDNSKNTLNLQMNSLRAEDTAVYYCARAPQWELVHEAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "SYVLTQPPSVSVAPGQTARITCGGNNLGSKSVHWYQQKPGQAPVLVVYDDSDRPSWIPERFSGSNSGNTATLTISRGEAGDEADYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.17, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 97.029, "unit": "%", "method": "SEC-HPLC (supplier CoA, 97.029% main peak)" } ] }, { "entry_id": "ICB-BSR-0195", "inn": "Prezalumab", "target": "B7H2", "target_uniprot": "O75144", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5214", "product_url": "https://ichor.bio/prezalumab-biosimilar-research-grade-ich5214", "rrid": "RRID:AB_3075864", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVAYIKQDGNEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGILWFGDLPTFWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISNWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYDSYPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.38, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0196", "inn": "Ganitumab", "target": "IGF1R", "target_uniprot": "P06213;P08069", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5216", "product_url": "https://ichor.bio/ganitumab-biosimilar-research-grade-ich5216", "rrid": "RRID:AB_3075866", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARWTGRTDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0197", "inn": "Datopotamab Deruxtecan", "target": "TROP2", "target_uniprot": "P09758", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5217D", "product_url": "https://ichor.bio/datopotamab-deruxtecan-biosimilar-research-grade-ich5217d", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWMGWINTHSGVPKYAEDFKGRVTISADTSTSTAYLQLSSLKSEDTAVYYCARSGFGSSYWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0198", "inn": "Lecanemab", "target": "Amyloid Beta", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5219", "product_url": "https://ichor.bio/lecanemab-biosimilar-research-grade", "rrid": "RRID:AB_3075869", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCSASGFTFSSFGMHWVRQAPGKGLEWVAYISSGSSTIYYGDTVKGRFTISRDNAKNSLFLQMSSLRAEDTAVYYCAREGGYYYGRSYYTMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTPGAPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLRISRVEAEDVGIYYCFQGSHVPPTFGPGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0199", "inn": "Amivantamab", "target": "EGFR + MET", "target_uniprot": "P00533;P08581", "format": "bispecific / multi-chain (4 chains)", "isotype": "IgG1 - kappa", "product_sku": "ICH5222", "product_url": "https://ichor.bio/amivantamab-biosimilar-research-grade", "rrid": "RRID:AB_3075872", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCETSGYTFTSYGISWVRQAPGHGLEWMGWISAYNGYTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDLRGTNYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISNWLAWFQHKPGKAPKLLIYAASSLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0200", "inn": "Tisotumab", "target": "CD142", "target_uniprot": "P13726", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5293", "product_url": "https://ichor.bio/tisotumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVSSISGSGDYTYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSPWGYYLDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPPSLSASAGDRVTITCRASQGISSRLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0201", "inn": "Tisotumab Vedotin", "target": "TF / Factor III / Tissue Factor / CD142", "target_uniprot": "P13726", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5293V", "product_url": "https://ichor.bio/tisotumab-vedotin-biosimilar-research-grade-ich5293v", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVSSISGSGDYTYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSPWGYYLDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPPSLSASAGDRVTITCRASQGISSRLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0202", "inn": "Depatuxizumab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5294", "product_url": "https://ichor.bio/depatuxizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGYSISSDFAWNWIRQPPGKGLEWMGYISYSGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTAGRGFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSMSVSVGDRVTITCHSSQDINSNIGWLQQKPGKSFKGLIYHGTNLDDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCVQYAQFPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0203", "inn": "Pozelimab", "target": "C5", "target_uniprot": "P01031", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5295", "product_url": "https://ichor.bio/pozelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGDSVSSSYWTWIRQPPGKGLEWIGYIYYSGSSNYNPSLKSRATISVDTSKNQFSLKLSSVTAADTAVYYCAREGNVDTTMIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "AIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKLLIYAASSLQSGVPSRFAGRGSGTDFTLTISSLQPEDFATYYCLQDFNYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.38, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0204", "inn": "Retifanlimab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5296", "product_url": "https://ichor.bio/retifanlimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYSFTSYWMNWVRQAPGQGLEWIGVIHPSDSETWLDQKFKDRVTITVDKSTSTAYMELSSLRSEDTAVYYCAREHYGTSPFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASESVDNYGMSFMNWFQQKPGQPPKLLIHAASNQGSGVPSRFSGSGSGTDFTLTISSLEPEDFAVYFCQQSKEVPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.35, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0205", "inn": "Ublituximab", "target": "CD20", "target_uniprot": "P11836", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5297", "product_url": "https://ichor.bio/ublituximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QAYLQQSGAELVRPGASVKMSCKASGYTFTSYNMHWVKQTPRQGLEWIGGIYPGNGDTSYNQKFKGKATLTVGKSSSTAYMQLSSLTSEDSAVYFCARYDYNYAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPARFSGSGSGTSYSFTISRVEAEDAATYYCQQWTFNPPTFGGGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.57, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0206", "inn": "Loncastuximab", "target": "CD19", "target_uniprot": "P15391;P51677", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5298", "product_url": "https://ichor.bio/loncastuximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQPGAEVVKPGASVKLSCKTSGYTFTSNWMHWVKQAPGQGLEWIGEIDPSDSYTNYNQNFQGKAKLTVDKSTSTAYMEVSSLRSDDTAVYYCARGSNPYYYAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPAIMSASPGERVTMTCSASSGVNYMHWYQQKPGTSPRRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEPEDAATYYCHQRGSYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.204, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.204% main peak)" } ] }, { "entry_id": "ICB-BSR-0207", "inn": "Crizanlizumab", "target": "SELP", "target_uniprot": "P16109", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5300", "product_url": "https://ichor.bio/crizanlizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYDINWVRQAPGKGLEWMGWIYPGDGSIKYNEKFKGRVTMTVDKSTDTAYMELSSLRSEDTAVYYCARRGEYGNYEGAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVTSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGMEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCAVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQSVDYDGHSYMNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSDENPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.46, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.767, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.767% main peak)" } ] }, { "entry_id": "ICB-BSR-0208", "inn": "Lanadelumab", "target": "KLKB1", "target_uniprot": "P03952", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5302", "product_url": "https://ichor.bio/lanadelumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVPRRDEFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0209", "inn": "Tildrakizumab", "target": "IL-23A", "target_uniprot": "Q9NPF7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5303", "product_url": "https://ichor.bio/tildrakizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFITYWMTWVRQAPGQGLEWMGQIFPASGSADYNEKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGGGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSENIYSYLAWYQQKPGKAPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGIPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0210", "inn": "Bezlotoxumab", "target": "Toxin B", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5304", "product_url": "https://ichor.bio/bezlotoxumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKSGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIFYPGDSSTRYSPSFQGQVTISADKSVNTAYLQWSSLKASDTAMYYCARRRNWGNAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSTWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0211", "inn": "Olaratumab", "target": "CD140a", "target_uniprot": "P16234", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5305", "product_url": "https://ichor.bio/olaratumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSINSSSYYWGWLRQSPGKGLEWIGSFFYTGSTYYNPSLRSRLTISVDTSKNQFSLMLSSVTAADTAVYYCARQSTYYYGSGNYYGWFDRWDQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPAFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0212", "inn": "Obiltoxaximab", "target": "Anthrax PA", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5306", "product_url": "https://ichor.bio/obiltoxaximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQQSGPELKKPGASVKVSCKDSGYAFSSSWMNWVRQAPGQGLEWIGRIYPGDGDTNYNGKFQGRVTITADKSSSTAYMELSSLRSEDTAVYFCARSGLLRYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAVKLLIYYTSRLLPGVPSRFSGSGSGTDYSLTISSQEQEDIGTYFCQQGNTLPWTFGQGTKVEIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0213", "inn": "Idarucizumab", "target": "Pradaxa", "target_uniprot": null, "format": "Fab fragment (1 H-fragment + 1 L)", "isotype": "Fab - G1 - kappa", "product_sku": "ICH5307", "product_url": "https://ichor.bio/idarucizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLTSYIVDWIRQPPGKGLEWIGVIWAGGSTGYNSALRSRVSITKDTSKNQFSLKLSSVTAADTAVYYCASAAYYSYYNYDGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSLLYTDGKTYLYWFLQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQSTHFPHTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 47.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.56, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0214", "inn": "Dinutuximab", "target": "Ganglioside GD2", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5308", "product_url": "https://ichor.bio/dinutuximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLQSGPELEKPGASVMISCKASGSSFTGYNMNWVRQNIGKSLEWIGAIDPYYGGTSYNQKFKGRATLTVDKSSSTAYMHLKSLTSEDSAVYYCVSGMEYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRSSQSLVHRNGNTYLHWYLQKPGQSPKLLIHKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0215", "inn": "Dostarlimab", "target": "PD-1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5311", "product_url": "https://ichor.bio/dostarlimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISGGGSYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASPYYAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQLTQSPSFLSAYVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTLHTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQHYSSYPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.84, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.065, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.065% main peak)" } ] }, { "entry_id": "ICB-BSR-0216", "inn": "Benralizumab", "target": "IL-5RA", "target_uniprot": "Q01344", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5313", "product_url": "https://ichor.bio/benralizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYVIHWVRQRPGQGLAWMGYINPYNDGTKYNERFKGKVTITSDRSTSTVYMELSSLRSEDTAVYLCGREGIRYYGLLGDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCGTSEDIINYLNWYQQKPGKAPKLLIYHTSRLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYTLPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.41, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.591, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.591% main peak)" } ] }, { "entry_id": "ICB-BSR-0217", "inn": "Telisotuzumab", "target": "MET", "target_uniprot": "P08581", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5315", "product_url": "https://ichor.bio/telisotuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFTAYTMHWVRQAPGQGLEWMGWIKPNNGLANYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSEITTEFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDCHCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSESVDSYANSFLHWYQQKPGQPPKLLIYRASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEDPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.41, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 95, "unit": "%", "method": "SEC-HPLC (supplier CoA, >95% spec)" } ] }, { "entry_id": "ICB-BSR-0218", "inn": "Telisotuzumab Vedotin", "target": "HGFR / c-Met", "target_uniprot": "P08581", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5315V", "product_url": "https://ichor.bio/telisotuzumab-vedotin-biosimilar-research-grade-ich5315v", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYIFTAYTMHWVRQAPGQGLEWMGWIKPNNGLANYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSEITTEFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDCHCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSESVDSYANSFLHWYQQKPGQPPKLLIYRASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEDPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0219", "inn": "Ravulizumab", "target": "Complement C5", "target_uniprot": "P01031", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-G4 - kappa", "product_sku": "ICH5317", "product_url": "https://ichor.bio/ravulizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGHIFSNYWIQWVRQAPGQGLEWMGEILPGSGHTEYTENFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYFFGSSPNWYFDVWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVLHEALHSHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCGASENIYGALNWYQQKPGKAPKLLIYGATNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLNTPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.31, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 99.763, "unit": "%", "method": "SEC-HPLC (supplier CoA, 99.763% main peak)" } ] }, { "entry_id": "ICB-BSR-0220", "inn": "Epcoritamab", "target": "CD3E + CD20", "target_uniprot": "P07766;P11836", "format": "bispecific / multi-chain (4 chains)", "isotype": "Ig(G1 - kappa_G1 - lambda2)", "product_sku": "ICH5319", "product_url": "https://ichor.bio/epcoritamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPDRSLRLSCAASGFTFHDYAMHWVRQAPGKGLEWVSTISWNSGTIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.28, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0221", "inn": "Faricimab", "target": "ANGPT2 + VEGFA", "target_uniprot": "O15123;P15692", "format": "Dual angiogenesis inhibitor (NOT a T-cell engager) | 1:1 bispecific IgG — 1 Fab per target, both monovalent | 2 Fabs (1 normal + 1 CrossMab) + heterodimeric Fc (4 chains)", "isotype": "Humanized IgG1", "product_sku": "ICH5320", "product_url": "https://ichor.bio/faricimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMASRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLAQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNAYTQKSLSLSPGK", "light_chain": "SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHWVFGGGTKLTVLSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.8, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0222", "inn": "Abagovomab", "target": "CA 125", "target_uniprot": "Q8WXI7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5321", "product_url": "https://ichor.bio/abagovomab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVKLQESGAELARPGASVKLSCKASGYTFTNYWMQWVKQRPGQGLDWIGAIYPGDGNTRYTHKFKGKATLTADKSSSTAYMQLSSLASEDSGVYYCARGEGNYAWFAYWGQGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "light_chain": "DIELTQSPASLSASVGETVTITCQASENIYSYLAWHQQKQGKSPQLLVYNAKTLAGGVSSRFSGSGSGTHFSLKIKSLQPEDFGIYYCQHHYGILPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.19, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0223", "inn": "Abelacimab", "target": "F11", "target_uniprot": "P03951", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5322", "product_url": "https://ichor.bio/abelacimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLLESGGGLVQPGGSLRLSCAASGFTFSTAAMSWVRQAPGKGLEWVSGISGSGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARELSYLYSGYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNDVSWYQQLPGTAPKLLIYKNYNRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCSAWDQRQFDVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0224", "inn": "Abrezekimab", "target": "IL13", "target_uniprot": "P35225", "format": "Fab fragment (1 H-fragment + 1 L)", "isotype": "Fab - G1 - kappa", "product_sku": "ICH5324", "product_url": "https://ichor.bio/abrezekimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVTLKESGPVLVKPTETLTLTCTVSGFSLTNYHVQWIRQPPGKALEWLGVMWSDGDTSFNSVLKSRLTISRDTSKSQVVLTMTNMDPVDTATYYCARDGTIAAMDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCLASEDISNYLAWYQQKPGKAPKLLIYHTSRLQDGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYRFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 47.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.14, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0225", "inn": "Actoxumab", "target": "toxin A [Clostridioides difficile]", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5326", "product_url": "https://ichor.bio/actoxumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFSFSNYGMHWVRQAPGKGLEWVALIWYDGSNEDYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARWGMVRGVIDVFDIWGQGTVVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQHKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.22, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0226", "inn": "Afasevikumab", "target": "IL17A", "target_uniprot": "Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5330", "product_url": "https://ichor.bio/afasevikumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGINWSSGGIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCARDIGGFGEFYWNFGLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVRSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPATFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.22, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0227", "inn": "Alsevalimab", "target": "VTCN1", "target_uniprot": "Q7Z7D3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5339", "product_url": "https://ichor.bio/alsevalimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSIKSGSYYWGWIRQPPGKGLEWIGNIYYSGSTYYNPSLRSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAREGSYPNQFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYHSFPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0228", "inn": "Andecaliximab", "target": "MMP9", "target_uniprot": "P14780", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5345", "product_url": "https://ichor.bio/andecaliximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLLSYGVHWVRQPPGKGLEWLGVIWTGGTTNYNSALMSRFTISKDDSKNTVYLKMNSLKTEDTAIYYCARYYYGMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSL", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVRNTVAWYQQKPGKAPKLLIYSSSYRNTGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQHYITPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0229", "inn": "Anrukinzumab", "target": "IL13", "target_uniprot": "P35225", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5347", "product_url": "https://ichor.bio/anrukinzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFISYAMSWVRQAPGKGLEWVASISSGGNTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLDGYYFGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEALGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASESVDNYGKSLMHWYQQKPGKAPKLLIYRASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0230", "inn": "Ascrinvacumab", "target": "ACVRL1", "target_uniprot": "P37023", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5355", "product_url": "https://ichor.bio/ascrinvacumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGEYYWNWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARESVAGFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0231", "inn": "Astegolimab", "target": "IL1RL1", "target_uniprot": "Q01638", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5356", "product_url": "https://ichor.bio/astegolimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFTNYWIGWVRQMPGKGLEWMGIIYPGNSDTRFSPSFQGQVTISADKSITTAYLQWSSLKASDTAMYYCARHGTSSDYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQDDNFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.45, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0232", "inn": "Atidortoxumab", "target": "alpha toxin", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5359", "product_url": "https://ichor.bio/atidortoxumab-biosimilar-research-grade-ich5359", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGPGLVRPSETLSLTCAVSGYSISSGMGWGWIRQPPGKGLEWIGSIDQRGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDAGHAVDMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISRWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYVFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0233", "inn": "Atinumab", "target": "RTN4", "target_uniprot": "Q9NQC3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5361", "product_url": "https://ichor.bio/atinumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMSWVRQAPGKGLEWVATIKQDGSQKNYVDSVKGRFTISRDNAKNSLYLRLNSLRAEDTAVYYCATELFDLWGRGSLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0234", "inn": "Atoltivimab", "target": "Zaire Ebola virus", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5362", "product_url": "https://ichor.bio/atoltivimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFNNYGMHWVRQAPGMGLEWVAVIWHDGSDKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARNWNLFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRITITCRASQSISTYLHWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSFSTPPINFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0235", "inn": "Avdoralimab", "target": "C5AR1", "target_uniprot": "P21730", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5364", "product_url": "https://ichor.bio/avdoralimab-biosimilar-research-grade-ich5364", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYVMHWVRQATGKGLEWVSAIDTGGGTYYADSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARDYYYYASGSYYKAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSRYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0236", "inn": "Avizakimab", "target": "IL21", "target_uniprot": "Q9HBE4", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5365", "product_url": "https://ichor.bio/avizakimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYWMHWVRQAPGQGLEWMGTIDPSDQYTIYSQNFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYGFAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCRASQDISNFLNWYQQKPGKAVKLLIYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGHTLPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0237", "inn": "Axatilimab", "target": "CSF1R", "target_uniprot": "P07333", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5366", "product_url": "https://ichor.bio/axatilimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVTLKESGPALVKPTQTLTLTCTFSGFSLTTYGMGVGWIRQPPGKALEWLANIWWDDDKYYNPSLKNRLTISKDTSKNQVVLTMTNMDPVDTATYYCARIGPIKYPTAPYRYFDFWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCLASEDIYDNLAWYQQKPGKAPKLLIYYASSLQDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCLQDSEYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0238", "inn": "Azintuxizumab", "target": "SLAMF7", "target_uniprot": "Q9NQ25", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5367", "product_url": "https://ichor.bio/azintuxizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMAWVRQAPGKGLEWVASINYDGSSTYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDRGYYFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQTPLSLSVTPGQPASISCRSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSTHVPPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0239", "inn": "Balstilimab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5369", "product_url": "https://ichor.bio/balstilimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASNGDHWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.08, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0240", "inn": "Bavituximab", "target": "phosphatidylserine [Homo sapiens]", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5376", "product_url": "https://ichor.bio/bavituximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQQSGPELEKPGASVKLSCKASGYSFTGYNMNWVKQSHGKSLEWIGHIDPYYGDTSYNQKFRGKATLTVDKSSSTAYMQLKSLTSEDSAVYYCVKGGYYGHWYFDVWGAGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASLGERVSLTCRASQDIGSSLNWLQQGPDGTIKRLIYATSSLDSGVPKRFSGSRSGSDYSLTISSLESEDFVDYYCLQYVSSPPTFGAGTKLELKRADAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0241", "inn": "Bedinvetmab", "target": "NGF", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5380", "product_url": "https://ichor.bio/bedinvetmab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGDLVKPGGSLRLSCVASGFTFSSHGMHWVRQSPGKGLQWVAVINSGGSSTYYTDAVKGRFTISRDNAKNTVYLQMNSLRAEDTAMYYCAKESVGGWEQLVGPHFDYWGQGTLVIVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEAAGAPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK", "light_chain": "QSVLTQPTSVSGSLGQRVTISCSGSTNNIGILGASWYQLFPGKAPKLLVYGNGNRPSGVPDRFSGADSGDSVTLTITGLQAEDEADYYCQSFDTTLGAHVFGGGTHLTVLGQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPVTQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.74, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0242", "inn": "Befovacimab", "target": "TFPI", "target_uniprot": "P10646", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5381", "product_url": "https://ichor.bio/befovacimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYGMDWVRQAPGKGLEWVSSIRGSRGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLYRYWFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "SYELTQPPSVSVSPGQTARITCSGDNLPKYYAHWYQQKPGQAPVVVIFYDVNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWWSSTPVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0243", "inn": "Begelomab", "target": "DPP4", "target_uniprot": "P27487", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2b - kappa", "product_sku": "ICH5382", "product_url": "https://ichor.bio/begelomab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQQSGAELVKPGASVKLSCKASGYTFRSYDINWVRQRPEQGLEWIGWIFPGDGSTKYNEKFKGKATLTTDKSSSTAYMQLSRLTSEDSAVYFCARWTVVGPGYFDVWGAGTTVTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "light_chain": "QIVLTQSPAIMSASPGEKVTITCSASSSVSYMNWFQQKPGTSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISRMEAEDAATYYCQQRSSYPNTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.04, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0244", "inn": "Benufutamab", "target": "TNFRSF10B", "target_uniprot": "O14763", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5390", "product_url": "https://ichor.bio/benufutamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQQSGAEVVKPGASVKLSCKASGFNIKDTFIHWVKQAPGQGLEWIGRIDPANTNTKYDPKFQGKATITTDTSSNTAYMELSSLRSEDTAVYYCVRGLYTYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHGALHNHYTQKSLSLSPG", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSISNNLHWYQQKPGQAPRLLIKFASQSITGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQGNSWPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0245", "inn": "Bepranemab", "target": "MAPT", "target_uniprot": "P10636", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5391", "product_url": "https://ichor.bio/bepranemab-biosimilar-research-grade-ich5391", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGPGLVKPSETLSLTCTVSGFSLTSNDIAWIRQPPGKGLEWMGTIWTDGSTNYNTAVQSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARHRLYYGAFDYWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSQSLEYSDGYTYLEWYLQKPGQSPQLLIYEVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQATHNPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.18, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0246", "inn": "Berlimatoxumab", "target": "LukGH", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5392", "product_url": "https://ichor.bio/berlimatoxumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "ELQLQESGPGLVKPSETLSLTCTVSGGSISSGSYYWDWIRQPPGKGLEWIGNIYKSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARERGMHYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSINSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQQFDPPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0247", "inn": "Bermekimab", "target": "IL1A", "target_uniprot": "P01583", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5393", "product_url": "https://ichor.bio/bermekimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCTASGFTFSMFGVHWVRQAPGKGLEWVAAVSYDGSNKYYAESVKGRFTISRDNSKNILFLQMDSLRLEDTAVYYCARGRPKVVIPAPLAHWGQGTLVTFSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYEASNLETGVPSRFSGSGSGSDFTLTISSLQPEDFATYYCQQTSSFLLSFGGGTKVEHKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.52, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0248", "inn": "Bersanlimab", "target": "ICAM1", "target_uniprot": "P05362", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5394", "product_url": "https://ichor.bio/bersanlimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVAFIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYSGWYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYDNNNRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCQSYDSSLSAWLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0249", "inn": "Bimagrumab", "target": "ACVR2B", "target_uniprot": "Q13705", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5402", "product_url": "https://ichor.bio/bimagrumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSSYINWVRQAPGQGLEWMGTINPVSGSTSYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGGWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGSYNYVNWYQQHPGKAPKLMIYGVSKRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCGTFAGGSYYGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0250", "inn": "Bimekizumab", "target": "IL17A", "target_uniprot": "Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5403", "product_url": "https://ichor.bio/bimekizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYNMAWVRQAPGKGLEWVATITYEGRNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASPPQYYEGSIYRLWFAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "AIQLTQSPSSLSASVGDRVTITCRADESVRTLMHWYQQKPGKAPKLLIYLVSNSEIGVPDRFSGSGSGTDFRLTISSLQPEDFATYYCQQTWSDPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0251", "inn": "Birtamimab", "target": "SAA1", "target_uniprot": "P0DJI8", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5404", "product_url": "https://ichor.bio/birtamimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMYWIRQAPGKGLEWVARIRSKSNNYAIYYADSVKDRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARPYSDSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSLVHSTGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0252", "inn": "Bleselumab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5407", "product_url": "https://ichor.bio/bleselumab-biosimilar-research-grade-ich5407", "rrid": "", "sequences": { "heavy_chain": "QLQLQESGPGLLKPSETLSLTCTVSGGSISSPGYYGGWIRQPPGKGLEWIGSIYKSGSTYHNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCTRPVVRYFGWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0253", "inn": "Blontuvetmab", "target": "MS4A1", "target_uniprot": "P11836", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - Vkappa-Clambda", "product_sku": "ICH5409", "product_url": "https://ichor.bio/blontuvetmab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQQSRAELVRPGASVTLSCKPSGYTFTDYEVHWVKQTPVHGLEWIGAIDPETGGTADNQKFKGKAILTADKSSSTAYMELRSLTSEDSAVYYCTNFVDVWGTGTTVTVSSASTTAPSVFPLAPSCGSQSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQKSLSHSPGK", "light_chain": "DVVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSGNQKNYLAWYQQKPGQSPRLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVFYCQQYYNYPLTFGGGTHLTVLGQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0254", "inn": "Brazikumab", "target": "IL23A", "target_uniprot": "Q9NPF7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5413", "product_url": "https://ichor.bio/brazikumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNEYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRGYTSSWYPDAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSSSNTGAGYDVHWYQQVPGTAPKLLIYGSGNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.12, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0255", "inn": "Brontictuzumab", "target": "NOTCH1", "target_uniprot": "P46531", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5416", "product_url": "https://ichor.bio/brontictuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKISCKVSGYTLRGYWIEWVRQAPGKGLEWIGQILPGTGRTNYNEKFKGRVTMTADTSTDTAYMELSSLRSEDTAVYYCARFDGNYGYYAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWFQQKPGQAPRTLIGGTNNRAPGVPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNHWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0256", "inn": "Budigalimab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5417", "product_url": "https://ichor.bio/budigalimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EIQLVQSGAEVKKPGSSVKVSCKASGYTFTHYGMNWVRQAPGQGLEWVGWVNTYTGEPTYADDFKGRLTFTLDTSTSTAYMELSSLRSEDTAVYYCTREGEGLGFGDWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTPGEPASISCRSSQSIVHSHGDTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIPVTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.75, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0257", "inn": "Cabiralizumab", "target": "CSF1R", "target_uniprot": "P07333", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5419", "product_url": "https://ichor.bio/cabiralizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDNYMIWVRQAPGQGLEWMGDINPYNGGTTFNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARESPYFSNLYVMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCKASQSVDYDGDNYMNWYQQKPGQAPRLLIYAASNLESGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHLSNEDLSTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.02, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0258", "inn": "Carotuximab", "target": "ENG", "target_uniprot": "P17813", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5428", "product_url": "https://ichor.bio/carotuximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVKLEESGGGLVQPGGSMKLSCAASGFTFSDAWMDWVRQSPEKGLEWVAEIRSKASNHATYYAESVKGRFTISRDDSKSSVYLQMNSLRAEDTGIYYCTRWRRFFDSWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWSSNPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0259", "inn": "Cendakimab", "target": "IL13", "target_uniprot": "P35225", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5432", "product_url": "https://ichor.bio/cendakimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVTLRESGPGLVKPTQTLTLTCTLYGFSLSTSDMGVDWIRQPPGKGLEWLAHIWWDDVKRYNPALKSRLTISKDTSKNQVVLKLTSVDPVDTATYYCARTVSSGYIYYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTISCRASQDIRNYLNWYQQKPGKAPKLLIFYTSKLHSGVPSRFSGSGSGTDYTLTISSLQPEDIATYYCQQGNTLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0260", "inn": "Cetrelimab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5434", "product_url": "https://ichor.bio/cetrelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFDTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARPGLAAAYDTGSLDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVRSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRNYWPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0261", "inn": "Cinpanemab", "target": "SNCA", "target_uniprot": "P37840", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5439", "product_url": "https://ichor.bio/cinpanemab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVEPGGSLRLSCAVSGFDFEKAWMSWVRQAPGQGLQWVARIKSTADGGTTSYAAPVEGRFIISRDDSRNMLYLQMNSLKTEDTAVYYCTSAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "SYELTQPPSVSVSPGQTARITCSGEALPMQFAHWYQQRPGKAPVIVVYKDSERPSGVPERFSGSSSGTTATLTITGVQAEDEADYYCQSPDSTNTYEVFGGGTKLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.53, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0262", "inn": "Cobolimab", "target": "HAVCR2", "target_uniprot": "Q8TDQ0", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5442", "product_url": "https://ichor.bio/cobolimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAAASGFTFSSYDMSWVRQAPGKGLDWVSTISGGGTYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSIRRYLNWYHQKPGKAPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQSHSAPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0263", "inn": "Cofetuzumab", "target": "PTK7", "target_uniprot": "Q13308", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5443", "product_url": "https://ichor.bio/cofetuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGPEVKKPGASVKVSCKASGYTFTDYAVHWVRQAPGKRLEWIGVISTYNDYTYNNQDFKGRVTMTRDTSASTAYMELSRLRSEDTAVYYCARGNSYFYALDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASESVDSYGKSFMHWYQQKPGQAPRLLIYRASNLESGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSNEDPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0264", "inn": "Conatumumab", "target": "TNFRSF10B", "target_uniprot": "O14763", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5445", "product_url": "https://ichor.bio/conatumumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGDYFWSWIRQLPGKGLEWIGHIHNSGTTYYNPSLKSRVTISVDTSKKQFSLRLSSVTAADTAVYYCARDRGGDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQGISRSYLAWYQQKPGQAPSLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0265", "inn": "Concizumab", "target": "TFPI", "target_uniprot": "P10646", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5447", "product_url": "https://ichor.bio/concizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQTPEKRLEWVATISRSGSYSYFPDSVQGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGGYDEGDAMDSWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLESDGKTYLNWYLQKPGQSPQLLIYLVSILDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQATHFPQTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.27, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0266", "inn": "Cosfroviximab", "target": "Zaire Ebola virus", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5450", "product_url": "https://ichor.bio/cosfroviximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0267", "inn": "Cosibelimab", "target": "PD-L1", "target_uniprot": "Q9NZQ7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5451", "product_url": "https://ichor.bio/cosibelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGGTFSRSAISWVRQAPGQGLEWMGVIIPAFGEANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGRQMFGAGIDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "NFMLTQPHSVSESPGKTVTISCTRSSGSIDSNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSNNRHVIFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0268", "inn": "Crenezumab", "target": "APP", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5454", "product_url": "https://ichor.bio/crenezumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKGLELVASINSNGGSTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASGDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLVYSNGDTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.63, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0269", "inn": "Crotedumab", "target": "GCGR", "target_uniprot": "P47871", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5456", "product_url": "https://ichor.bio/crotedumab-biosimilar-research-grade-ich5456", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYLMNWVRQAPGKGLEWLANIQEDGIEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREPSHYDILTGYDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFILTVSSLQPEDFATYYCLQYNSNPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.59, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0270", "inn": "Crovalimab", "target": "C5", "target_uniprot": "P01031", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5457", "product_url": "https://ichor.bio/crovalimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGLVQPGRSLRLSCAASGFTVHSSYYMAWVRQAPGKGLEWVGAIFTGSGAEYKAEWAKGRVTISKDTSKNQVVLTMTNMDPVDTATYYCASDAGYDYPTHAMHYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELRRGPKVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHAHYTRKELSLSP", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSSLAWYQQKPGKAPKLLIYGASETESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNTKVGSSYGNTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0271", "inn": "Cudarolimab", "target": "TNFRSF4", "target_uniprot": "P43489", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5458", "product_url": "https://ichor.bio/cudarolimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGRPWYSETGTSAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQSDHYPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0272", "inn": "Dalotuzumab", "target": "IGF1R", "target_uniprot": "P06213;P08069", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5463", "product_url": "https://ichor.bio/dalotuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGYSITGGYLWNWIRQPPGKGLEWIGYISYDGTNNYKPSLKDRVTISRDTSKNQFSLKLSSVTAADTAVYYCARYGRVFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSIVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRLYGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0273", "inn": "Dectrekumab", "target": "IL13", "target_uniprot": "P35225", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5470", "product_url": "https://ichor.bio/dectrekumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLWFGDLDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERAILSCRAGQSVSSYLVWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSSWPPVYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0274", "inn": "Demcizumab", "target": "DLL4", "target_uniprot": "Q9NR61", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5472", "product_url": "https://ichor.bio/demcizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKISCKASGYSFTAYYIHWVKQAPGQGLEWIGYISSYNGATNYNQKFKGRVTFTTDTSTSTAYMELRSLRSDDTAVYYCARDYDYDVGMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVMTQSPDSLAVSLGERATISCRASESVDNYGISFMKWFQQKPGQPPKLLIYAASNQGSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEVPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.62, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0275", "inn": "Demupitamab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5473", "product_url": "https://ichor.bio/demupitamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSTLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0276", "inn": "Dezamizumab", "target": "APCS", "target_uniprot": "P02743", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5478", "product_url": "https://ichor.bio/dezamizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGFTFATYNMHWVRQAPGQGLEWMGYIYPGDGNANYNQQFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGDFDYDGGYYFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASENIYSYLAWYQQKPGKAPKLLIHNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGAPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0277", "inn": "Diridavumab", "target": "influenza A virus hemagglutinin HA2 subunit from various strains", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5481", "product_url": "https://ichor.bio/diridavumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0278", "inn": "Disitamab", "target": "ERBB2", "target_uniprot": "P04626", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5482", "product_url": "https://ichor.bio/disitamab-biosimilar-research-grade-ich5482", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGATVKISCKVSGYTFTDYYIHWVQQAPGKGLEWMGRVNPDHGDSYYNQKFKDKATITADKSTDTAYMELSSLRSEDTAVYFCARNYLFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCHQFATYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0279", "inn": "Disitamab Vedotin", "target": "ERBB2 / HER2 / CD340", "target_uniprot": "P04626", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5482V", "product_url": "https://ichor.bio/disitamab-vedotin-biosimilar-research-grade-ich5482v", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGATVKISCKVSGYTFTDYYIHWVQQAPGKGLEWMGRVNPDHGDSYYNQKFKDKATITADKSTDTAYMELSSLRSEDTAVYFCARNYLFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCHQFATYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0280", "inn": "Docaravimab", "target": "ERA", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2b - kappa", "product_sku": "ICH5484", "product_url": "https://ichor.bio/docaravimab-biosimilar-research-grade-ich5484", "rrid": "", "sequences": { "heavy_chain": "QVQLKESGPGLLAPSQSLSITCTVSGFSLTGHGVNWVRQPPGKGLEWLGIIWADGTTNYNSALKSRLSISKDNSKSQVFLKMNSLQTDDTASYYCAREGDISGYYFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "light_chain": "DVQMTQTTSSLSASLGDRVTITCRPSQDINNYLSWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDFATYFCQQGNTLPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.48, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0281", "inn": "Domagrozumab", "target": "MSTN", "target_uniprot": "O14793", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5485", "product_url": "https://ichor.bio/domagrozumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSTISSGGSYTSYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKQDYAMNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHYSTPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0282", "inn": "Donanemab", "target": "APP", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5487", "product_url": "https://ichor.bio/donanemab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYDFTRYYINWVRQAPGQGLEWMGWINPGSGNTKYNEKFKGRVTITADESTSTAYMELSSLRSEDTAVYYCAREGITVYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLYSRGKTYLNWLLQKPGQSPQLLIYAVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVQGTHYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0283", "inn": "Dovanvetmab", "target": "Felcat IL31", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5489", "product_url": "https://ichor.bio/dovanvetmab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVLLVQSGAEVRTPGASVKIFCKASGYSFTSYTIHWLRQAPAQGLEWMGNINPTSGYTENNQRFKDRLTLTADTSTNTAYMELSSLRSADTAMYYCARWGFKYDGEWSFDVWGAGTTVTVSSASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEAAGAPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "light_chain": "EIQMTQSPSSLSASPGDRVTITCRASQGISIWLSWYQQKPGNIPKVLINKASNLHIGVPSRFSGSGSGTDFTLTISSLEPEDAATYYCLQSQTYPLTFGGGTKLEIKRSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFQRSEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.77, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0284", "inn": "Drozitumab", "target": "TNFRSF10B", "target_uniprot": "O14763", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda3", "product_sku": "ICH5491", "product_url": "https://ichor.bio/drozitumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGGGVERPGGSLRLSCAASGFTFDDYAMSWVRQAPGKGLEWVSGINWQGGSTGYADSVKGRVTISRDNAKNSLYLQMNSLRAEDTAVYYCAKILGAGRGWYFDYWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "SELTQDPAVSVALGQTVRITCSGDSLRSYYASWYQQKPGQAPVLVIYGANNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSADSSGNHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0285", "inn": "Duligotuzumab", "target": "ERBB3", "target_uniprot": "P21860", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5493", "product_url": "https://ichor.bio/duligotuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTLSGDWIHWVRQAPGKGLEWVGEISAAGGYTDYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARESRVSFEAAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQNIATDVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSEPEPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.66, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0286", "inn": "Dusigitumab", "target": "IGF2", "target_uniprot": "P01344", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5494", "product_url": "https://ichor.bio/dusigitumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYDINWVRQATGQGLEWMGWMNPNSGNTGYAQKFQGRVTMTRNTSISTAYMELSSLRSEDTAVYYCARDPYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSVSAAPGQKVTISCSGSSSNIENNHVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCETWDTSLSAGRVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.87, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0287", "inn": "Elezanumab", "target": "RGMA", "target_uniprot": "Q96B86", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5512", "product_url": "https://ichor.bio/elezanumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTSHGISWVRQAPGQGLDWMGWISPYSGNTNYAQKLQGRVTMTTDTSTSTAYMELSSLRSEDTAVYYCARVGSGPYYYMDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDQLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHNHYTQKSLSLSPGK", "light_chain": "QSALTQPRSVSGSPGQSVTISCTGTSSSVGDSIYVSWYQQHPGKAPKLMLYDVTKRPSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCYSYAGTDTLFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0288", "inn": "Elgemtumab", "target": "ERBB3", "target_uniprot": "P21860", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5513", "product_url": "https://ichor.bio/elgemtumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAINSQGKSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARWGDEGFDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISNWLAWYQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSFPTTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0289", "inn": "Elipovimab", "target": "HIV-1", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5514", "product_url": "https://ichor.bio/elipovimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QMQLQESGPGLVKPSETLSLTCSVSGASISDSYWSWIRRSPGKGLEWIGYVHKSGDTNYNPSLKSRVHLSLDTSKNQVSLSLTGVTAADSGKYYCARTLHGRRIYGIVAFNEWFTYFYMDVWGTGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLAGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPLPEEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK", "light_chain": "SDISVAPGETARISCGEKSLGSRAVQWYQHRAGQAPSLIIYNNQDRPSGIPERFSGSPDSRPGTTATLTITSVEAGDEADYYCHIWDSRVPTKWVFGGGTTLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.91, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0290", "inn": "Emactuzumab", "target": "CSF1R", "target_uniprot": "P07333", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5518", "product_url": "https://ichor.bio/emactuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYDISWVRQAPGQGLEWMGVIWTDGGTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDQRLYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASEDVNTYVSWYQQKPGKAPKLLIYAASNRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSFSYPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0291", "inn": "Enapotamab", "target": "AXL", "target_uniprot": "P30530", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5522", "product_url": "https://ichor.bio/enapotamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTTSGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKIWIAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0292", "inn": "Enapotamab Vedotin", "target": "AXL / UFO", "target_uniprot": "P30530", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5522V", "product_url": "https://ichor.bio/enapotamab-vedotin-biosimilar-research-grade-ich5522v", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTTSGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKIWIAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0293", "inn": "Enavatuzumab", "target": "TNFRSF12A", "target_uniprot": "Q9NP84", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5523", "product_url": "https://ichor.bio/enavatuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVAEIRLKSDNYATHYAESVKGRFTISRDDSKNSLYLQMNSLRAEDTAVYYCTGYYADAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKLLIKYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWEIPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0294", "inn": "Encelimab", "target": "LAG3", "target_uniprot": "P18627", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5524", "product_url": "https://ichor.bio/encelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGATVKISCKASGFSIKDDYIHWVQQAPGKGLEWMGWIDAMNDDSQYSSKFQGRVTITVDTSTNTAYMKLSSLRSEDTAVYYCTYAFGGYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSDSNTYLHWYLQKPGQSPQLLIYLVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCGQSTHVPYAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.69, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0295", "inn": "Enoticumab", "target": "DLL4", "target_uniprot": "Q9NR61", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5526", "product_url": "https://ichor.bio/enoticumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVSFLWYDGTNKNYVESVKGRFTISRDNSKNMLYLEMNSLRAEDTAVYYCARDHDFRSGYEGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHRSNWPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0296", "inn": "Ensituximab", "target": "MUC5AC", "target_uniprot": "P98088", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5527", "product_url": "https://ichor.bio/ensituximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLKESGPDLVAPSQSLSITCTVSGFSLSKFGVNWVRQPPGKGLEWLGVIWGDGSTSYNSGLISRLSISKENSKSQVFLKLNSLQADDTATYYCVKPGGDYWGHGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGPYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTMPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QVVLTQSPVIMSASPGEKVTMTCSASSSISYMYWYQQKPGTSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISNMEAGDAATYYCHQRDSYPWTFGGGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0297", "inn": "Etaracizumab", "target": "ITGAV_ITGB3", "target_uniprot": "P06756;P05106", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5534", "product_url": "https://ichor.bio/etaracizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVAKVSSGGGSTYYLDTVQGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARHLHGSFASWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCQASQSISNFLHWYQQRPGQAPRLLIRYRSQSISGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSGSWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.44, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0298", "inn": "Etigilimab", "target": "TIGIT", "target_uniprot": "Q495A1", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5536", "product_url": "https://ichor.bio/etigilimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCAVSGYSITSDYAWNWIRQPPGKGLEWIGYISYSGSTSYNPSLRSRVTISRDTSKNQFFLKLSSVTAADTAVYYCARRQVGLGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQHYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSNTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.58, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0299", "inn": "Favezelimab", "target": "LAG3", "target_uniprot": "P18627", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5545", "product_url": "https://ichor.bio/favezelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QMQLVQSGPEVKKPGTSVKVSCKASGYTFTDYNVDWVRQARGQRLEWIGDINPNDGGTIYAQKFQERVTITVDKSTSTAYMELSSLRSEDTAVYYCARNYRWFGAMDHWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCKASQSLDYEGDSDMNWYLQKPGQPPQLLIYGASNLESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQSTEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.02, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0300", "inn": "Felzartamab", "target": "CD38", "target_uniprot": "P28907", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5547", "product_url": "https://ichor.bio/felzartamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFSSYYMNWVRQAPGKGLEWVSGISGDPSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLPLVYTGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIELTQPPSVSVAPGQTARISCSGDNLRHYYVYWYQQKPGQAPVLVIYGDSKRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCQTYTGGASLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0301", "inn": "Fianlimab", "target": "LAG3", "target_uniprot": "P18627", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5548", "product_url": "https://ichor.bio/fianlimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCVASGFTFSSYGMHWVRQAPGKGLEWVAIIWYDGSNKYYADSVKGRFTISRDNSKNTQYLQMNSLRAEDTAVYYCASVATSGDFDYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERTTLSCRASQRISTYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTGFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0302", "inn": "Firivumab", "target": "influenza A virus hemagglutinin HA [Influenza A virus]", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5551", "product_url": "https://ichor.bio/firivumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKMPGSSVKVSCKTSGVFFSSHAISWVRQAPGQGLEWMGGISPMFGTTHYAQKFQGRVTITADQSTTTAYMELTSLTSEDTAVYYCARDGAGSYYPLNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASENIWNNLAWYQQKPGQAPRLLISGASTGATGVPSRFRGSGSRTEFTLTISSLQSEDFAIYFCQQYNSWPRTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.22, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0303", "inn": "Flanvotumab", "target": "TYRP1", "target_uniprot": "P17643", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5553", "product_url": "https://ichor.bio/flanvotumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGSELKKPGASVKISCKASGYTFTSYAMNWVRQAPGQGLESMGWINTNTGNPTYAQGFTGRFVFSMDTSVSTAYLQISSLKAEDTAIYYCAPRYSSSWYLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWLMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0304", "inn": "Foravirumab", "target": "RABV", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5555", "product_url": "https://ichor.bio/foravirumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGAVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVILYDGSDKFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKVAVAGTHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQLNSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0305", "inn": "Frovocimab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5558", "product_url": "https://ichor.bio/frovocimab-biosimilar-research-grade-ich5558", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFPFSKLGMVWVRQAPGKGLEWVSTISSGGGYTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGISFQGGTYTYVMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSKSLLHRNGITYSYWYLQKPGQSPQLLIYQLSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCYQNLELPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.09, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0306", "inn": "Frunevetmab", "target": "Felcat NGF", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5559", "product_url": "https://ichor.bio/frunevetmab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGAELVQPGESLRLTCAASGFSLTNNNVNWVRQAPGKGLEWMGGVWAGGATDYNSALKSRLTITRDTSKNTVFLQMHSLQSEDTATYYCARDGGYSSSTLYAMDAWGQGTTVTVSAASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "light_chain": "DIEMTQSPLSLSVTPGESVSISCRASEDIYNALAWYLQKPGRSPRLLIYNTDTLHTGVPDRFSGSGSGTDFTLKISRVQTEDVGVYFCQHYFHYPRTFGQGTKLELKRSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFNRSECQRE", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 148.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0307", "inn": "Futuximab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5560", "product_url": "https://ichor.bio/futuximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQQPGSELVRPGASVKLSCKASGYTFTSYWMHWVKQRPGQGLEWIGNIYPGSRSTNYDEKFKSKATLTVDTSSSTAYMQLSSLTSEDSAVYYCTRNGDYYVSSGDAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQTTSSLSASLGDRVTISCRTSQDIGNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDFSLTINNVEQEDVATYFCQHYNTVPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.16, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0308", "inn": "Garadacimab", "target": "F12", "target_uniprot": "P00748", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - lambda", "product_sku": "ICH5563", "product_url": "https://ichor.bio/garadacimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSKYIMQWVRQAPGKGLEWVSGIDIPTKGTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARALPRSGYLISPHYYYYALDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGRNYVYWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDASLRGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0309", "inn": "Garetosmab", "target": "INHBA", "target_uniprot": "P08476", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5564", "product_url": "https://ichor.bio/garetosmab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGGSFSSHFWSWIRQPPGKGLEWIGYILYTGGTSFNPSLKSRVSMSVGTSKNQFSLKLSSVTAADTAVYYCARARSGITFTGIIVPGSFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.08, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0310", "inn": "Gatipotuzumab", "target": "MUC1", "target_uniprot": "P15941", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5566", "product_url": "https://ichor.bio/gatipotuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSMRLSCVASGFPFSNYWMNWVRQAPGKGLEWVGEIRLKSNNYTTHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCTRHYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSNPVTPGEPASISCRSSKSLLHSNGITYFFWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLRISRVEAEDVGVYYCAQNLELPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0311", "inn": "Gatralimab", "target": "CD52", "target_uniprot": "P31358", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5567", "product_url": "https://ichor.bio/gatralimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFPFSNYWMNWVRQAPGKGLEWVGQIRLKSNNYATHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCTPIDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLYSNGKTYLNWVLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVQGSHFHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0312", "inn": "Gedivumab", "target": "influenza A virus hemagglutinin HA [Influenza A virus]", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5569", "product_url": "https://ichor.bio/gedivumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGVVQPGKSLRLSCAASGLTFSSYAVHWVRQAPGKGLEWVTLISYDGANQYYADSVKGRFTISRDNSKNTVYLQMNSLRPEDTAVYYCAVPGPVFGIFPPWSYFDNWGQGILVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSVSPGERATLSCRASQVISHNLAWYQQKPGQAPRLLIYGASTRASGIPARFSGSGSGTDYTLTITSLQSEDFAVYYCQHYSNWPPRLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0313", "inn": "Giloralimab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5571", "product_url": "https://ichor.bio/giloralimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGPGLVKPSETLSLTCTVSGYSITSNYYWNWIRQPPGKGLEWMGYIRYDGSNNYNPSLKNRVTISRDTSKNQFSLKLSSVTAADTAVYYCARLDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEEKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCRSSQSLENTNGNTFLNWYLQKPGQSPQLLIYRVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQVTHVPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0314", "inn": "Gilvetmab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5572", "product_url": "https://ichor.bio/gilvetmab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGGDLVKPGGSVRLSCVASGFNIKNTYMHWVRQAPGKGLQWIGRIAPANVDTKYAPKFQGKATISADTAKNTAYMQLNSLRAEDTAVYYCVLIYYDYDGDIDVWGQGTLVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVALDPEDPEVQISWFVDGKQMQTAKTQPREEQFAGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPGK", "light_chain": "DIVMTQTPLSLSVSLGEPASISCHASQNINVWLSWYRQKPGQIPQLLIYKASHLHTGVPDRFSGSGSGTDFTLRISRVEADDAGVYYCQQGQSWPLTFGQGTKVEIKRNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDSKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 148.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.58, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0315", "inn": "Gimsilumab", "target": "CSF2", "target_uniprot": "P04141", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5574", "product_url": "https://ichor.bio/gimsilumab-biosimilar-research-grade-ich5574", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRHWMHWLRQVPGKGPVWVSRINGAGTSITYADSVRGRFTISRDNANNTLFLQMNSLRADDTALYFCARANSVWFRGLFDYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVVHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPVTLSVSPGERVTLSCRASQSVSTNLAWYQQKLGQGPRLLIYGASTRATDIPARFSGSGSETEFTLTISSLQSEDFAVYYCQQYDKWPDTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.34, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0316", "inn": "Glembatumumab Vedotin", "target": "GPNMB", "target_uniprot": "Q14956", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-Kappa", "product_sku": "ICH5575V", "product_url": "https://ichor.bio/glembatumumab-vedotin-biosimilar-research-grade-ich5575v", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGGSISSFNYYWSWIRHHPGKGLEWIGYIYYSGSTYSNPSLKSRVTISVDTSKNQFSLTLSSVTAADTAVYYCARGYNWNYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVDNNLVWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.87, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0317", "inn": "Glenzocimab", "target": "GP6", "target_uniprot": "Q9HCN6", "format": "Fab fragment (1 H-fragment + 1 L)", "isotype": "Fab - G1 - kappa", "product_sku": "ICH5576", "product_url": "https://ichor.bio/glenzocimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGGIYPGNGDTSYNQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGTVVGDWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLENSNGNTYLNWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQLTHVPWTFGQGTKVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 48.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.57, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0318", "inn": "Gosuranemab", "target": "MAPT", "target_uniprot": "P10636", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5582", "product_url": "https://ichor.bio/gosuranemab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVHLVESGGALVKPGGSLRLSCAASGFSFSKYGMSWVRQAPGKGLEWVATISSSGSRTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAMYYCSISWDGAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSIVHSNGNTYLEWYLQKPGQSPQLLVYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGTYYCFQGSLVPWAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0319", "inn": "Ianalumab", "target": "TNFRSF13C", "target_uniprot": "Q96RJ3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5587", "product_url": "https://ichor.bio/ianalumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWGWIRQSPGRGLEWLGRIYYRSKWYNSYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARYDWVPKIGVFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVLTQSPATLSLSPGERATLSCRASQFISSSYLSWYQQKPGQAPRLLIYGSSSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQLYSSPMTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0320", "inn": "Icrucumab", "target": "FLT1", "target_uniprot": "P17948", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5589", "product_url": "https://ichor.bio/icrucumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QAQVVESGGGVVQSGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSENTLYLQMNSLRAEDTAVYYCARDHYGSGVHHYFYYGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0321", "inn": "Ifabotuzumab", "target": "EPHA3", "target_uniprot": "P29320", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5591", "product_url": "https://ichor.bio/ifabotuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYWMNWVRQAPGQGLEWMGDIYPGSGNTNYDEKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGGYYEDFDSWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSFLSASVGDRVTITCRASQGIISYLAWYQQKPEKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCGQYANYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0322", "inn": "Iladatuzumab", "target": "CD79B", "target_uniprot": "P40259", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5593", "product_url": "https://ichor.bio/iladatuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSSCSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.63, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0323", "inn": "Iladatuzumab Vedotin", "target": "CD79b", "target_uniprot": "P40259", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5593V", "product_url": "https://ichor.bio/iladatuzumab-vedotin-biosimilar-research-grade-ich5593v", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSSCSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.63, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0324", "inn": "Imalumab", "target": "MIF", "target_uniprot": "P14174", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5595", "product_url": "https://ichor.bio/imalumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSIYSMNWVRQAPGKGLEWVSSIGSSGGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGSQWLYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQRIMTYLNWYQQKPGKAPKLLIFVASHSQSGVPSRFRGSGSETDFTLTISGLQPEDSATYYCQQSFWTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0325", "inn": "Imaprelimab", "target": "MCAM", "target_uniprot": "P43121", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5596", "product_url": "https://ichor.bio/imaprelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVTLKESGPVLVKPTETLTLTCTVSGFSLTSNAVSWVRQPPGKALEWIAAISSGGTTYYNSAFKSRLTISRDTSKSQVVLTMTNMDPVDTATYYCARRYGYGWYFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTINCKASQNIYNSLAWYQQKPGKAPKVLIFNANSLQTGIPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFYSGYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0326", "inn": "Imgatuzumab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5600", "product_url": "https://ichor.bio/imgatuzumab-biosimilar-research-grade-ich5600", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGFTFTDYKIHWVRQAPGQGLEWMGYFNPNSGYSTYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSPGGYYVMDAWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGINNYLNWYQQKPGKAPKRLIYNTNNLQTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSFPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.5, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0327", "inn": "Inclacumab", "target": "SELP", "target_uniprot": "P16109", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5602", "product_url": "https://ichor.bio/inclacumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVRPGGSLRLSCAASGFTFSNYDMHWVRQATGKGLEWVSAITAAGDIYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGRYSGSGSYYNDWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0328", "inn": "Indusatumab Vedotin", "target": "GUCY2C", "target_uniprot": "P25092", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1(E356D/M358L)-Kappa", "product_sku": "ICH5604V", "product_url": "https://ichor.bio/indusatumab-vedotin-biosimilar-research-grade-ich5604v", "rrid": "", "sequences": { "heavy_chain": "QVQLQQWGAGLLKPSETLSLTCAVFGGSFSGYYWSWIRQPPGKGLEWIGEINHRGNTNDNPSLKSRVTISVDTSKNQFALKLSSVTAADTAVYYCARERGYTYGNFDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSVSRNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTIGSLQSEDFAVYYCQQYKTWPRTFGQGTNVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.59, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0329", "inn": "Intetumumab", "target": "ITGAV_ITGB3", "target_uniprot": "P06756;P05106", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5608", "product_url": "https://ichor.bio/intetumumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSRRLSCAASGFTFSRYTMHWVRQAPGKGLEWVAVISFDGSNKYYVDSVKGRFTISRDNSENTLYLQVNILRAEDTAVYYCAREARGSYAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0330", "inn": "Iscalimab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5610", "product_url": "https://ichor.bio/iscalimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYEESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIAAPGPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSLTVTPGEPASISCRSSQSLLYSNGYNYLDWYLQKPGQSPQVLISLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQARQTPFTFGPGTKVDIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.08, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0331", "inn": "Itolizumab", "target": "CD6", "target_uniprot": "P30203", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5611", "product_url": "https://ichor.bio/itolizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLKLSCAASGFKFSRYAMSWVRQAPGKRLEWVATISSGGSYIYYPDSVKGRFTISRDNVKNTLYLQMSSLRSEDTAMYYCARRDYDLDYFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASRDIRSYLTWYQQKPGKAPKTLIYYATSLADGVPSRFSGSGSGQDYSLTISSLESDDTATYYCLQHGESPFTLGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0332", "inn": "Labetuzumab Govitecan", "target": "CEACAM5 / CEA / CD66e", "target_uniprot": "P06731", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5617G", "product_url": "https://ichor.bio/labetuzumab-govitecan-biosimilar-research-grade-ich5617g", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCSASGFDFTTYWMSWVRQAPGKGLEWIGEIHPDSSTINYAPSLKDRFTISRDNAKNTLFLQMDSLRPEDTGVYFCASLYFGFPWFAYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSLSASVGDRVTITCKASQDVGTSVAWYQQKPGKAPKLLIYWTSTRHTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYSLYRSFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0333", "inn": "Lacnotuzumab", "target": "CSF1", "target_uniprot": "P09603", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5618", "product_url": "https://ichor.bio/lacnotuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSDYSITSDYAWNWIRQFPGKGLEWMGYISYSGSTSYNPSLKSRITISRDTSKNQFSLQLNSVTAADTAVYYCASFDYAHAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVLTQSPAFLSVTPGEKVTFTCQASQSIGTSIHWYQQKTDQAPKLLIKYASESISGIPSRFSGSGSGTDFTLTISSVEAEDAADYYCQQINSWPTTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0334", "inn": "Lacutamab", "target": "KIR3DL2", "target_uniprot": "P43630", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5619", "product_url": "https://ichor.bio/lacutamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QIQLVQSGSELKKPGASVKVSCKASGYTFTTAGMQWVRQAPGQGLEWIGWINSHSGVPKYAEDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYFCARGGDEGVMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPEEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSFLSASVGDRVTITCKASQDVSTAVAWYQQKPGQPPKLLIYWTSTRHTGVPDRFSGSGSGTDYTLTISSLQAEDVAVYYCQQHYSTPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0335", "inn": "Ladiratuzumab", "target": "SLC39A6", "target_uniprot": "Q13433", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5620", "product_url": "https://ichor.bio/ladiratuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGLTIEDYYMHWVRQAPGQGLEWMGWIDPENGDTEYGPKFQGRVTMTRDTSINTAYMELSRLRSDDTAVYYCAVHNAHYGTWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLLHSSGNTYLEWYQQRPGQSPRPLIYKISTRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0336", "inn": "Ladiratuzumab Vedotin", "target": "LIV-1 / SLC39A6", "target_uniprot": "Q13433", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5620V", "product_url": "https://ichor.bio/ladiratuzumab-vedotin-biosimilar-research-grade-ich5620v", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGLTIEDYYMHWVRQAPGQGLEWMGWIDPENGDTEYGPKFQGRVTMTRDTSINTAYMELSRLRSDDTAVYYCAVHNAHYGTWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLLHSSGNTYLEWYQQRPGQSPRPLIYKISTRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0337", "inn": "Lampalizumab", "target": "CFD", "target_uniprot": "P00746", "format": "Fab fragment (1 H-fragment + 1 L)", "isotype": "Fab - G1 - kappa", "product_sku": "ICH5622", "product_url": "https://ichor.bio/lampalizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGGVNNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQVTQSPSSLSASVGDRVTITCITSTDIDDDMNWYQQKPGKVPKLLISGGNTLRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 47.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.64, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0338", "inn": "Landogrozumab", "target": "MSTN", "target_uniprot": "O14793", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5624", "product_url": "https://ichor.bio/landogrozumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGLTFSRYPMSWVRQAPGKGLVWVSAITSSGGSTYYSDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARLPDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASSSVSSSYLHWYQQKPGQAPRLLIYSTSNLVAGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHHSGYHFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0339", "inn": "Laprituximab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5626", "product_url": "https://ichor.bio/laprituximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVAKPGASVKLSCKASGYTFTSYWMQWVKQRPGQGLECIGTIYPGDGDTTYTQKFQGKATLTADKSSSTAYMQLSSLRSEDSAVYYCARYDAPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDINNYLAWYQHKPGKGPKLLIHYTSTLHPGIPSRFSGSGSGRDYSFSISSLEPEDIATYYCLQYDNLLYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.87, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0340", "inn": "Laprituximab Emtansine", "target": "ERBB1 / EGFR / HER1", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5626E", "product_url": "https://ichor.bio/laprituximab-emtansine-biosimilar-research-grade-ich5626e", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVAKPGASVKLSCKASGYTFTSYWMQWVKQRPGQGLECIGTIYPGDGDTTYTQKFQGKATLTADKSSSTAYMQLSSLRSEDSAVYYCARYDAPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDINNYLAWYQHKPGKGPKLLIHYTSTLHPGIPSRFSGSGSGRDYSFSISSLEPEDIATYYCLQYDNLLYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.87, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0341", "inn": "Larcaviximab", "target": "Zaire Ebola virus", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5627", "product_url": "https://ichor.bio/larcaviximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGPELEMPGASVKISCKASGSSFTGFSMNWVKQSNGKSLEWIGNIDTYYGGTTYNQKFKGKATLTVDKSSSTAYMQLKSLTSEDSAVYYCARSAYYGSTFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNAKTLIEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYFCQHHFGTPFTFGSGTELEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0342", "inn": "Lenvervimab", "target": "HBV", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5632", "product_url": "https://ichor.bio/lenvervimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCSASGFSLTKYKMTWVRQAPGKGLEWVSSISSTSRDIDYADSVKGRFTISRDNAKNSLFLQMSSLRVDDTAVYYCTRDGWLWGWDVRSNYYYNALDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVVTQSPSSLSASVGDRVTITCRASQGIYNSIAWYQQKPGKAPKLLLYSTSTLLSGVPSRFSGSGSGTDYTLTITNLQPEDFATYYCQQYFVTPETFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0343", "inn": "Leronlimab", "target": "CCR5", "target_uniprot": "P51681", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5634", "product_url": "https://ichor.bio/leronlimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGYTFSNYWIGWVRQAPGKGLEWIGDIYPGGNYIRNNEKFKDKTTLSADTSKNTAYLQMNSLKTEDTAVYYCGSSFGSNYVFAWFTYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQRLLSSYGHTYLHWYLQKPGQSPQLLIYEVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.12, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0344", "inn": "Lesofavumab", "target": "influenza B virus hemagglutinin [Influenza B virus]", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5637", "product_url": "https://ichor.bio/lesofavumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKVSGYSFTSQWIGWVRQMPGKGLEWIGMMYPGESETIYSPSFQGQVTISADNSISTAYLQWSSLKASDTAIYYCASGPGYSGYHYGWFDTWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLRSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQALQTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0345", "inn": "Levilimab", "target": "IL6R", "target_uniprot": "P08887", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5639", "product_url": "https://ichor.bio/levilimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGGGLVQPGGSLRLSCAASGFTFSSYYMSWVRQAPGKGLEWVSGIYSDGTTHYGDSVKGRFTISRDNAKNTVYLQLNSLRAEDTAMYYCAKGAGPTWWYALDAWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPPVAGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSSVSVSVGERVTIDCKSSQSVLSASNTYLNWYQQKPGQAPQLLIYYASTRESGVPDRFSGSGSGTDFTLTISSLQAEDAAVYYCQQAYRAPVTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0346", "inn": "Lexatumumab", "target": "TNFRSF10B", "target_uniprot": "O14763", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5640", "product_url": "https://ichor.bio/lexatumumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGGGVERPGGSLRLSCAASGFTFDDYGMSWVRQAPGKGLEWVSGINWNGGSTGYADSVKGRVTISRDNAKNSLYLQMNSLRAEDTAVYYCAKILGAGRGWYFDLWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0347", "inn": "Ligelizumab", "target": "IGHE", "target_uniprot": "P01854", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5644", "product_url": "https://ichor.bio/ligelizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVMKPGSSVKVSCKASGYTFSWYWLEWVRQAPGHGLEWMGEIDPGTFTTNYNEKFKARVTFTADTSTSTAYMELSSLRSEDTAVYYCARFSHFSGSNYDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQSIGTNIHWYQQKPGQAPRLLIYYASESISGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQSWSWPTTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.16, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0348", "inn": "Lilotomab", "target": "CD37", "target_uniprot": "P11049", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5645", "product_url": "https://ichor.bio/lilotomab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EIQLQQSGPELVKPGASVKVSCKASGYSFTDYNMYWVKQSHGKSLEWIGYIDPYNGDTTYNQKFKGKATLTVDKSSSTAFIHLNSLTSEDSAVYYCARSPYGHYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "light_chain": "DIVMTQSHKLLSTSVGDRVSITCKASQDVSTAVDWYQQKPGQSPKLLINWASTRHTGVPDRFTGSGSGTDYTLTISSMQAEDLALYYCRQHYSTPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0349", "inn": "Lodapolimab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda", "product_sku": "ICH5651", "product_url": "https://ichor.bio/lodapolimab-biosimilar-research-grade-ich5651", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARSPDYSPYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCQSYDSSLSGSVFGGGIKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPAECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0350", "inn": "Lodelcizumab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5652", "product_url": "https://ichor.bio/lodelcizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFSTMYMSWVRQAPGQGLEWMGRIDPANEHTNYAQKFQGRVTMTRDTSISTAYMELSRLTSDDTAVYYCARSYYYYNMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QIVLTQSPATLSVSPGERATLSCRASQSVSYMHWYQQKPGQAPRLLIYGVFRRATGIPDRFSGSGSGTDFTLTIGRLEPEDFAVYYCLQWSSDPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0351", "inn": "Lokivetmab", "target": "IL31", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5653", "product_url": "https://ichor.bio/lokivetmab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGDLVKPGGSLRLSCVASGFTFSNYGMSWVRQAPGKGLQWVATISYGGSYTYYPDNIKGRFTISRDNAKNTLYLQMNSLRAEDTAMYYCVRGYGYDTMDYWGQGTLVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQESLSHSPG", "light_chain": "EIVMTQSPASLSLSQEEKVTITCKASQSVSFAGTGLMHWYQQKPGQAPKLLIYRASNLEAGVPSRFSGSGSGTDFSFTISSLEPEDVAVYYCQQSREYPWTFGQGTKLEIKRNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.11, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0352", "inn": "Losatuxizumab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5657", "product_url": "https://ichor.bio/losatuxizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGPGLVKPSQTLSLTCTVSGYSISRDFAWNWIRQPPGKGLEWMGYISYNGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTASRGFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSMSVSVGDRVTITCHSSQDINSNIGWLQQKPGKSFKGLIYHGTNLDDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCVQYAQFPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0353", "inn": "Lumretuzumab", "target": "ERBB3", "target_uniprot": "P21860", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5660", "product_url": "https://ichor.bio/lumretuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFRSSYISWVRQAPGQGLEWMGWIYAGTGSPSYNQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARHRDYYSNSLTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQSDYSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0354", "inn": "Lupartumab", "target": "LYPD3", "target_uniprot": "O95274", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5663", "product_url": "https://ichor.bio/lupartumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVSYISSSGSTIYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAREGLWAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "ESVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYVVHWYQQLPGTAPKLLIYDNNKRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDRLNGPVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0355", "inn": "Maftivimab", "target": "Zaire Ebola virus", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5666", "product_url": "https://ichor.bio/maftivimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTSSSYAMNWVRQAPGKGLEWVSTISGMGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKRGYPHSFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSFLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0356", "inn": "Manelimab", "target": "PD-L1", "target_uniprot": "Q9NZQ7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5667", "product_url": "https://ichor.bio/manelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGVVRPGGSLRLSCAASGFTFDDYAMSWVRQAPGKGLEWVSDISWSGSNTNYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYHCARAPLLLAMTFGVGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QTVVTQEPSLSVSPGGTVTLTCGLSSGTVTAINYPGWYQQTPGQAPRTLIYNTNTRHSGVPDRFSGSISGNKAALTITGAQAEDEADYYCALYMGNGGHMFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.91, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0357", "inn": "Marstacimab", "target": "TFPI", "target_uniprot": "P10646", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5671", "product_url": "https://ichor.bio/marstacimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAILGATSLSAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGSGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0358", "inn": "Mezagitamab", "target": "CD38", "target_uniprot": "P28907", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda", "product_sku": "ICH5679", "product_url": "https://ichor.bio/mezagitamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFDDYGMSWVRQAPGKGLEWVSDISWNGGKTHYVDSVKGQFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGSLFHDSSGFYFGHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSSSNIGDNYVSWYQQLPGTAPKLLIYRDSQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0359", "inn": "Milatuzumab", "target": "CD74", "target_uniprot": "P04233", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5681", "product_url": "https://ichor.bio/milatuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGVNWIKQAPGQGLQWMGWINPNTGEPTFDDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCSRSRGKNEAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPLSLPVTLGQPASISCRSSQSLVHRNGNTYLHWFQQRPGQSPRLLIYTVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSSHVPPTFGAGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.52, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0360", "inn": "Mirikizumab", "target": "IL23A", "target_uniprot": "Q9NPF7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5683", "product_url": "https://ichor.bio/mirikizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYKFTRYVMHWVRQAPGQGLEWMGYINPYNDGTNYNEKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNWDTGLWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASDHILKFLTWYQQKPGKAPKLLIYGATSLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQMYWSTPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0361", "inn": "Mirococept", "target": "complement C3b, C4b [Homo sapiens]", "target_uniprot": "P0C0L5", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "Conjugate - CR1 (complement receptor type 1, C3b/C4b receptor, C3BR, Knops blood group, KN, CD35) 41-238_peptidyl-myristoylated", "product_sku": "ICH5684", "product_url": "https://ichor.bio/mirococept-biosimilar-research-grade-ich5684", "rrid": "", "sequences": { "heavy_chain": "DIQMTQSPSSLSASVGDRVTITCKASQNVGTNVAWYQQKPGKAPKALIYSASFLYSGVPYRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "AKTIAYDEEARRGLERGLNALADAVKVTLGKWGAPTITNDGVSIAKEIELEDPYEKIGAEPKGRNVVLEKLVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKGDQSIGDLIAAVEKVTETLLKGAKEVETKEQIAATAAISAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDFHMHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQ", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 254.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 5.23, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0362", "inn": "Miromavimab", "target": "ERA", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5685", "product_url": "https://ichor.bio/miromavimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQQPGSVLVRPGASVKLSCKTSGYAFTSSWMHWAKQRPGQGLEWIGQTHPNSGYTNYNEKFKGKATLTVDTSSSTAYVDLSSLTSEDSAVYYCARESGDGPHWYFDVWGAGTAVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "light_chain": "DIVMTQSHKFMSTSVGDRVSITCKASQDVSTAVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSSPHTFGGGTKLETKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0363", "inn": "Mirzotamab", "target": "CD276", "target_uniprot": "Q5ZPR3", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5687", "product_url": "https://ichor.bio/mirzotamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGPGLVKPSETLSLTCAVTGYSITSGYSWHWIRQFPGNGLEWMGYIHSSGSTNYNPSLKSRISISRDTSKNQFFLKLSSVTAADTAVYYCAGYDDYFEYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQNVGFNVAWYQQKPGKSPKALIYSASYRYSGVPSRFSGSGSGTDFTLTISSLQPEDFAEYFCQQYNWYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0364", "inn": "Mitazalimab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5689", "product_url": "https://ichor.bio/mitazalimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYGMHWVRQAPGKGLEWLSYISGGSSYIFYADSVRGRFTISRDNSENALYLQMNSLRAEDTAVYYCARILRGGSGMDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCTGSSSNIGAGYNVYWYQQLPGTAPKLLIYGNINRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDKSISGLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0365", "inn": "Modotuximab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5691", "product_url": "https://ichor.bio/modotuximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQQPGAELVEPGGSVKLSCKASGYTFTSHWMHWVKQRPGQGLEWIGEINPSSGRNNYNEKFKSKATLTVDKSSSTAYMQFSSLTSEDSAVYYCVRYYGYDEAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIVMTQAAFSNPVTLGTSASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSSSGSGTDFTLRISRVEAEDVGVYYCAQNLELPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0366", "inn": "Murlentamab", "target": "AMHR2", "target_uniprot": "Q16671", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5694", "product_url": "https://ichor.bio/murlentamab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVRLVQSGAEVKKPGASVKVSCKASGYTFTSYHIHWVRQAPGQRLEWMGWIYPGDDSTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCTRGDRFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASSSVRYIAWYQQKPGKAPKLLTYPTSSLKSGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCLQWSSYPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.76, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0367", "inn": "Namilumab", "target": "CSF2", "target_uniprot": "P04141", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5697", "product_url": "https://ichor.bio/namilumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKAFGYPFTDYLLHWVRQAPGQGLEWVGWLNPYSGDTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCTRTTLISVYFDYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSVSASVGDRVTIACRASQNIRNILNWYQQRPGKAPQLLIYAASNLQSGVPSRFSGSGSGTDFTLTINSLQPEDFATYYCQQSYSMPRTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0368", "inn": "Naratuximab", "target": "CD37", "target_uniprot": "P11049", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5698", "product_url": "https://ichor.bio/naratuximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQVQESGPGLVAPSQTLSITCTVSGFSLTTSGVSWVRQPPGKGLEWLGVIWGDGSTNYHPSLKSRLSIKKDHSKSQVFLKLNSLTAADTATYYCAKGGYSLAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSVSVGERVTITCRASENIRSNLAWYQQKPGKSPKLLVNVATNLADGVPSRFSGSGSGTDYSLKINSLQPEDFGTYYCQHYWGTTWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0369", "inn": "Narnatumab", "target": "MST1R", "target_uniprot": "Q04912", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5699", "product_url": "https://ichor.bio/narnatumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYLMTWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLNLQMNSLRAEDTAVYYCTRDGYSSGRHYGMDVWGQGTTVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSRYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0370", "inn": "Narsoplimab", "target": "MASP2", "target_uniprot": "O00187", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - lambda2", "product_sku": "ICH5700", "product_url": "https://ichor.bio/narsoplimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVTLKESGPVLVKPTETLTLTCTVSGFSLSRGKMGVSWIRQPPGKALEWLAHIFSSDEKSYRTSLKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCARIRRGGIDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "QPVLTQPPSLSVSPGQTASITCSGEKLGDKYAYWYQQKPGQSPVLVMYQDKQRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTAVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0371", "inn": "Navivumab", "target": "influenza A virus hemagglutinin HA [Influenza A virus]", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5702", "product_url": "https://ichor.bio/navivumab-biosimilar-research-grade-ich5702", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKTSGYSFSTYGVSWVRQAPGQGPEWVGWISAYTGITDYAQKFQGRVTLTTDATTATAFLDLRSLRPDDTATYFCARDKVQGRVEVGSGGRHDYWGQGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", "light_chain": "EVVLTQSPGTLALPPGERATLSCRASHRVGSTYIAWYQQKSGQAPRRLIYGASNRATDIPDRFSGSGSGTDFTLTIRRLEPEDSAVYYCQQFSVSPWTFGQGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.59, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0372", "inn": "Netakimab", "target": "IL17A", "target_uniprot": "Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5709", "product_url": "https://ichor.bio/netakimab-biosimilar-research-grade-ich5709", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGGGLVQAGGSLRLSCAASGGTFATSPMGWLRQAPGKGTEFVAAISPSGGDRIYADSVKGRFTISRDNAGYFIYLQMNSLKPEDTAVYYCAVRRRFDGTSYYTGDYDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYSYSPVTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0373", "inn": "Nimacimab", "target": "CNR1", "target_uniprot": "P21554", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5711", "product_url": "https://ichor.bio/nimacimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYEFSYYWMNWVRQAPGQGLEWMGQIYPGDGETKYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARSHGNYLPYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSSYLHWYQQKPGQAPRLLIYSTSNLASGIPARFSGSGSGTDFTLTISRLEPEDFAVYYCHQYHRSPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0374", "inn": "Nirsevimab", "target": "RSV", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5712", "product_url": "https://ichor.bio/nirsevimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0375", "inn": "Nurulimab", "target": "CTLA4", "target_uniprot": "P16410", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5717", "product_url": "https://ichor.bio/nurulimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0376", "inn": "Obexelimab", "target": "CD19", "target_uniprot": "P15391;P51677", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5719", "product_url": "https://ichor.bio/obexelimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKYNEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVEHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKAFPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLNSGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0377", "inn": "Ocaratuzumab", "target": "MS4A1", "target_uniprot": "P11836", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5721", "product_url": "https://ichor.bio/ocaratuzumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGRTFTSYNMHWVRQMPGKGLEWMGAIYPLTGDTSYNQKSKLQVTISADKSISTAYLQWSSLKASDTAMYYCARSTYVGGDWQFDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKIKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKQKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASSSVPYIHWYQQKPGQAPRLLIYATSALASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQWLSNPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0378", "inn": "Odesivimab", "target": "Zaire Ebola virus", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5723", "product_url": "https://ichor.bio/odesivimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYDMHWVRQATGKGLEWVSAIGTAGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARTWFGELYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTEFTLTITSLQAEDVAVYYCQQYYSSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0379", "inn": "Olendalizumab", "target": "C5", "target_uniprot": "P01031", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2-G4 - kappa", "product_sku": "ICH5727", "product_url": "https://ichor.bio/olendalizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYSMDWVRQAPGQGLEWMGAIHLNTGYTNYNQKFKGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGFYDGYSPMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASESVDSYGNSFMHWYQQKPGKAPKLLIYRASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.45, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0380", "inn": "Olinvacimab", "target": "KDR", "target_uniprot": "P35968", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - Vlambda-Ckappa", "product_sku": "ICH5729", "product_url": "https://ichor.bio/olinvacimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QMQLVQSGAEVKKPGASVKLSCKASGYTFSSYWMHWVRQAPGQRLEWMGEINPGNGHTNYNEKFKSRVTITVDKSASTAYMELSSLRSEDTAVYYCAKIWGPSLTSPFDYWGQGTLVTVSSGLGGLASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "NFMLTQPPSVSVSPGKTARITCRGDNLGDVNVHWYQQRPGQAPVLVMYYDADRPSGIPERFSGSNSGNTATLTISGVEAGDEADYYCQVWDRTSEYVFGTGTKVTVLGGGASLVERSVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 148.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.68, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0381", "inn": "Ongericimab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5733", "product_url": "https://ichor.bio/ongericimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCTVSGFSISSYGIHWIRQSPGKGLEWIGVIWRGGITDYNAPFMSRVTISKDNSKNQVSFKLSSVTAADTAVYYCANHRDWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDINKYIDWYQHKPGKAPKLLIHYASTLQPGVPSRFSGSGSGRDYTFTISSLQPEDIATYYCLQYDDLWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0382", "inn": "Ontamalimab", "target": "MADCAM1", "target_uniprot": "Q13477", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5734", "product_url": "https://ichor.bio/ontamalimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGINWVRQAPGQGLEWMGWISVYSGNTNYAQKVQGRVTMTADTSTSTAYMDLRSLRSDDTAVYYCAREGSSSSGDYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQTPLSLSVTPGQPASISCKSSQSLLHTDGTTYLYWYLQKPGQPPQLLIYEVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGIYYCMQNIQLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.1, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0383", "inn": "Ontuxizumab", "target": "CD248", "target_uniprot": "Q9HCU0", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5736", "product_url": "https://ichor.bio/ontuxizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVRPSQTLSLTCTASGYTFTDYVIHWVKQPPGRGLEWIGYINPYDDDTTYNQKFKGRVTMLVDTSSNTAYLRLSSVTAEDTAVYYCARRGNSYDGYFDYSMDYWGSGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGFFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQNVGTAVAWLQQTPGKAPKLLIYSASNRYTGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQYTNYPMYTFGQGTKVQIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0384", "inn": "Opicinumab", "target": "LINGO1", "target_uniprot": "Q96FE5", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5738", "product_url": "https://ichor.bio/opicinumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSAYEMKWVRQAPGKGLEWVSVIGPSGGFTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATEGDNDAFDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSAYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.11, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0385", "inn": "Orilanolimab", "target": "FCGRT", "target_uniprot": "P55899", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5744", "product_url": "https://ichor.bio/orilanolimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAELKKPGASVKLSCKASGYTFTSYGISWVKQATGQGLEWIGEIYPRSGNTYYNEKFKGRATLTADKSTSTAYMELRSLRSEDSAVYFCARSTTVRPPGIWGTGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASDHINNWLAWYQQKPGQAPRLLISGATSLETGVPSRFSGSGTGKDYTLTISSLQPEDFATYYCQQYWSTPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0386", "inn": "Orticumab", "target": "oxLDL", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5746", "product_url": "https://ichor.bio/orticumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVSSISVGGHRTYYADSVKGRSTISRDNSKNTLYLQMNSLRAEDTAVYYCARIRVGPSGGAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQPPSASGTPGQRVTISCSGSNTNIGKNYVSWYQQLPGTAPKLLIYANSNRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCASWDASLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.6, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0387", "inn": "Osocimab", "target": "F11", "target_uniprot": "P03951", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5747", "product_url": "https://ichor.bio/osocimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSQYGMDWVRQAPGKGLEWVSGIGPSGGSTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGGPYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQADSFPVTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.84, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0388", "inn": "Otilimab", "target": "CSF2", "target_uniprot": "P04141", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5748", "product_url": "https://ichor.bio/otilimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMNWVRQAPGKGLEWVSGIENKYAGGATYYAASVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGFGTDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIELTQPPSVSVAPGQTARISCSGDSIGKKYAYWYQQKPGQAPVLVIYKKRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCSAWGDKGMVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0389", "inn": "Pacmilimab", "target": "PD-L1", "target_uniprot": "Q9NZQ7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5752", "product_url": "https://ichor.bio/pacmilimab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSSIWRNGIVTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKWSAAFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "QGQSGSGIALCPSHFCQLPQTGGGSSGGSGGSGGISSGLLSGRSDNHGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQDNGYPSTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 152.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0390", "inn": "Pamrevlumab", "target": "CTGF", "target_uniprot": "P29279", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5754", "product_url": "https://ichor.bio/pamrevlumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EGQLVQSGGGLVHPGGSLRLSCAGSGFTFSSYGMHWVRQAPGKGLEWVSGIGTGGGTYSTDSVKGRFTISRDNAKNSLYLQMNSLRAEDMAVYYCARGDYYGSGSFFDCWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPPTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0391", "inn": "Pateclizumab", "target": "LTA", "target_uniprot": "P01374", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5757", "product_url": "https://ichor.bio/pateclizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYVIHWVRQAPGKGLEWVGYNNPYNAGTNYNEKFKGRFTISSDKSKNTAYLQMNSLRAEDTAVYYCSRPTMLPWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQAVSSAVAWYQQKPGKAPKLLIYSASHRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQESYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0392", "inn": "Pepinemab", "target": "SEMA4D", "target_uniprot": "Q92854", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5768", "product_url": "https://ichor.bio/pepinemab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYSFSDYYMHWVRQAPGQGLEWMGQINPTTGGASYNQKFKGKATITVDKSTSTAYMELSSLRSEDTAVYYCARYYYGRHFDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSNEDPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0393", "inn": "Perakizumab", "target": "IL17A", "target_uniprot": "Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5769", "product_url": "https://ichor.bio/perakizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYTMLWVRQAPGKGLEWVAIIKSGGSYSYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDGDYGSSYGAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDINSYLSWFQQKPGKAPKSLIVRANRLVDGVPSRFSGSGSGQDYSLTISSLQPEDFATYYCLQYDAFPPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0394", "inn": "Pidilizumab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5773", "product_url": "https://ichor.bio/pidilizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGSELKKPGASVKISCKASGYTFTNYGMNWVRQAPGQGLQWMGWINTDSGESTYAEEFKGRFVFSLDTSVNTAYLQITSLTAEDTGMYFCVRVGYDALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPSSLSASVGDRVTITCSARSSVSYMHWFQQKPGKAPKLWIYRTSNLASGVPSRFSGSGSGTSYCLTINSLQPEDFATYYCQQRSSFPLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0395", "inn": "Plozalizumab", "target": "CCR2", "target_uniprot": "P41597", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5778", "product_url": "https://ichor.bio/plozalizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSAYAMNWVRQAPGKGLEWVGRIRTKNNNYATYYADSVKDRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTFYGNGVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTLGQPASISCKSSQSLLDSDGKTFLNWFQQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPYTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0396", "inn": "Porgaviximab", "target": "Zaire Ebola virus", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5780", "product_url": "https://ichor.bio/porgaviximab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGGGLMQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFTISRDDSKRSVYLQMNTLRAEDTGIYYCTRGNGNYRAMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPASLSVSVGETVSITCRASENIYSSLAWYQQKQGKSPQLLVYSATILADGVPSRFSGSGSGTQYSLKINSLQSEDFGTYYCQHFWGTPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0397", "inn": "Praluzatamab", "target": "ALCAM", "target_uniprot": "Q13740", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5785", "product_url": "https://ichor.bio/praluzatamab-biosimilar-research-grade-ich5785", "rrid": "", "sequences": { "heavy_chain": "QITLKESGPTLVKPTQTLTLTCTFSGFSLSTYGMGVGWIRQPPGKALEWLANIWWSEDKHYSPSLKSRLTITKDTSKNQVVLTITNVDPVDTATYYCVQIDYGNDYAFTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QGQSGQGLCHPAVLSAWESCSSGGGSSGGSAVGLLAPPGGLSGRSDNHGGSDIVMTQSPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 156.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.17, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0398", "inn": "Praluzatamab Ravtansine", "target": "ALCAM / CD166", "target_uniprot": "Q13740", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5785R", "product_url": "https://ichor.bio/praluzatamab-ravtansine-biosimilar-research-grade-ich5785r", "rrid": "", "sequences": { "heavy_chain": "QITLKESGPTLVKPTQTLTLTCTFSGFSLSTYGMGVGWIRQPPGKALEWLANIWWSEDKHYSPSLKSRLTITKDTSKNQVVLTITNVDPVDTATYYCVQIDYGNDYAFTYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QGQSGQGLCHPAVLSAWESCSSGGGSSGGSAVGLLAPPGGLSGRSDNHGGSDIVMTQSPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 156.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.17, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0399", "inn": "Prasinezumab", "target": "SNCA", "target_uniprot": "P37840", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5786", "product_url": "https://ichor.bio/prasinezumab-biosimilar-research-grade-ich5786", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASISSGGGSTYYPDNVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARGGAGIDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKSIQTLLYSSNQKNYLAWFQQKPGKAPKLLIYWASIRKSGVPSRFSGSGSGTDFTLTISSLQPEDLATYYCQQYYSYPLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.5, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0400", "inn": "Pritoxaximab", "target": "shiga toxin type 1", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5789", "product_url": "https://ichor.bio/pritoxaximab-biosimilar-research-grade-ich5789", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGAELVRSGASVRMSCKASGYTFTSYNMHWVKQTPGQGLEWIGYIYPGNGGTNYIQKFKGKAILTADTSSSTAYMQISSLTSEDSAVYFCTRSPSHYSSDPYFDYWGQGTTLTVSSEFASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMSQSHKFMSTSVGDRVSITCKASQDVGTAVAWYQQNPGQSPKFLIYWASTRHTGVPDRFTGSGSGTDFTLTITNVQSEDLADYFCQQYSSYPLTFGAGTSLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.17, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0401", "inn": "Prolgolimab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - Vlambda-Ckappa", "product_sku": "ICH5791", "product_url": "https://ichor.bio/prolgolimab-biosimilar-research-grade-ich5791", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGGGLVQPGGSLRLSCAASGFTFSSYWMYWVRQVPGKGLEWVSAIDTGGGRTYYADSVKGRFAISRVNAKNTMYLQMNSLRAEDTAVYYCARDEGGGTGWGVLKDWPYGLDAWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QPVLTQPLSVSVALGQTARITCGGNNIGSKNVHWYQQKPGQAPVLVIYRDSNRPSGIPERFSGSNSGNTATLTISRAQAGDEADYYCQVWDSSTAVFGTGTKLTVLQRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0402", "inn": "Quavonlimab", "target": "CTLA4", "target_uniprot": "P16410", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5794", "product_url": "https://ichor.bio/quavonlimab-biosimilar-research-grade-ich5794", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDNWMNWVRQAPGKGLEWLAQIRNKPYNYETYYSASVKGRFTISRDDSKNSVYLQMNSLKTEDTGVYYCTAQFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRTSENIYGGLNWYQRKPGKSPKLLIYGATNLASGVSSRFSGSGSGTDYTLTISSLQPEDVATYYCQNVLRSPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0403", "inn": "Quetmolimab", "target": "CX3CL1", "target_uniprot": "P78423", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5795", "product_url": "https://ichor.bio/quetmolimab-biosimilar-research-grade-ich5795", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYIHWVKQAPGQGLEWIGWIYPGDGSPKFNERFKGRTTLTADKSTNTAYMLLSSLRSEDTAVYFCATGPTDGDYFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPAAAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASGNIHNFLAWYQQKPGKAPKLLIYNEKTLADGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQFWSTPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0404", "inn": "Quilizumab", "target": "IGHE", "target_uniprot": "P01854", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5796", "product_url": "https://ichor.bio/quilizumab-biosimilar-research-grade-ich5796", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYGIAWVRQAPGKGLEWVAFISDLAYTIYYADTVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDNWDAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRSSQSLVHNNANTYLHWYQQKPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCSQNTLVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0405", "inn": "Racotumomab", "target": "idiotope of anti-", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5797", "product_url": "https://ichor.bio/racotumomab-biosimilar-research-grade-ich5797", "rrid": "", "sequences": { "heavy_chain": "QVQLQQSGAELVKPGASVKLSCKASGYTFTSYDINWVRQRPEQGLEWIGWIFPGDGSTKYNEKFKGKATLTTDKSSSTAYMQLSRLTSEDSAVYFCAREDYYDNSYYFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK", "light_chain": "DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.35, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0406", "inn": "Rafivirumab", "target": "RABV", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5799", "product_url": "https://ichor.bio/rafivirumab-biosimilar-research-grade-ich5799", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFNRYTVNWVRQAPGQGLEWMGGIIPIFGTANYAQRFQGRLTITADESTSTAYMELSSLRSDDTAVYFCARENLDNSGTYYYFSGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "QSALTQPRSVSGSPGQSVTISCTGTSSDIGGYNFVSWYQQHPGKAPKLMIYDATKRPSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCCSYAGDYTPGVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.88, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0407", "inn": "Ralpancizumab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5801", "product_url": "https://ichor.bio/ralpancizumab-biosimilar-research-grade-ich5801", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGEIHPSGGRTNYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARERPLYASDLWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVHTAVAWYQQKPGKAPKLLIYHASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQRYSLWRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0408", "inn": "Ranevetmab", "target": "NGF", "target_uniprot": "P01138", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5805", "product_url": "https://ichor.bio/ranevetmab-biosimilar-research-grade-ich5805", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCVASGFSLTNNNVNWVRQAPGKGLEWVGGVWAGGATDYNSALKSRFTISRDNAKNTVFLQMHSLRSEDTAVYYCARDGGYSSSTLYAMDAWGQGTSVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLHSLSSMVTVPSSRWPSETFTCNVVHPASNTKVDKPVFNECRCTDTPPCPVPEPLGGPSVLIFPPKPKDILRITRTPEVTCVVLDLGREDPEVQISWFVDGKEVHTAKTQSREQQFNGTYRVVSVLPIEHQDWLTGKEFKCRVNHIDLPSPIERTISKARGRAHKPSVYVLPPSPKELSSSDTVSITCLIKDFYPPDIDVEWQSNGQQEPERKHRMTPPQLDEDGSYFLYSKLSVDKSRWQQGDPFTCAVMHETLQNHYTDLSLSHSPGK", "light_chain": "DIVMTQSPASLSLSQGETVTITCRASEDIYNALAWYQQKPGQAPKLLIYNTDTLHTGVPSRFSGSGSGTDFSLTISSLEPEDVAVYYCQHYFHYPRTFGQGTKVELKRNDAQPAVYLFQPSPDQLHTGSASVVCLLNSFYPKDINVKWKVDGVIQDTGIQESVTEQDKDSTYSLSSTLTMSSTEYLSHELYSCEITHKSLPSTLIKSFQRSECQRVD", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 5.79, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0409", "inn": "Ravagalimab", "target": "CD40", "target_uniprot": "P25942", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5806", "product_url": "https://ichor.bio/ravagalimab-biosimilar-research-grade-ich5806", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSDYGMNWVRQAPGKGLEWIAYISSGRGNIYYADTVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARSWGYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDQLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSLLNRGNQKNYLTWFQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYTYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0410", "inn": "Refanezumab", "target": "MAG", "target_uniprot": "P20916", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5810", "product_url": "https://ichor.bio/refanezumab-biosimilar-research-grade-ich5810", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGSELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGEPTYADDFTGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPINYYGINYEGYVMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSHSVLYSSNQKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCHQYLSSLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 148.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0411", "inn": "Relfovetmab", "target": "Felcat NGF", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5814", "product_url": "https://ichor.bio/relfovetmab-biosimilar-research-grade-ich5814", "rrid": "", "sequences": { "heavy_chain": "DVQLVESGGDLVKPGGSLRLTCVASGFTYSNYWMHWVRQAPGKGLQWVARIDPYGGGTKHNEKFKRRFTISRDNAKNTLYLQMNSLKTEDTATYYCVRSGYDYYFDVWGQGTLVTVSSASTTAPSVFPLAPSCGTTSGATVALACLVLGYFPEPVTVSWNSGALTSGVHTFPAVLQASGLYSLSSMVTVPSSRWLSDTFTCNVAHPPSNTKVDKTVRKTDHPPGPKPCDCPKCPPPEMLGGPSIFIFPPKPKDTLSISRTPEVTCLVVDLGPDDSDVQITWFVDNTQVYTAKTSPREEQFNSTYRVVSVLPILHQDWLKGKEFKCKVNSKSLPSPIERTISKAKGQPHEPQVYVLPPAQEELSRNKVSVTCLIKSFHPPDIAVEWEITGQPEPENNYRTTPPQLDSDGTYFVYSKLSVDRSHWQRGNTYTCSVSHEALHSHHTQKSLTQSPGK", "light_chain": "EIQMTQSPSSLSASPGDRVTITCRASENIYSFLAWYQQKPGKVPKLLIYNANTLAEGVPSRFSGSGSGTDFTLTISSLEPEDAATYYCQHHFGTPFTFGSGTKLEIKRSDAQPSVFLFQPSLDELHTGSASIVCILNDFYPKEVNVKWKVDGVVQNKGIQESTTEQNSKDSTYSLSSTLTMSSTEYQSHEKFSCEVTHKSLASTLVKSFQRSECQRE", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 148.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.22, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0412", "inn": "Revdofilimab", "target": "TNFRSF4", "target_uniprot": "P43489", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5818", "product_url": "https://ichor.bio/revdofilimab-biosimilar-research-grade-ich5818", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYGMSWVRQAPGKGLELVATINSNGGRTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGITTAYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKASQSVDYDGDSYMHWYQQKPGQPPKLLIYAASILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSNEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.87, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0413", "inn": "Rinucumab", "target": "PDGFRB", "target_uniprot": "P09619", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5825", "product_url": "https://ichor.bio/rinucumab-biosimilar-research-grade-ich5825", "rrid": "", "sequences": { "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSITSSSYYWGWIRQPPGKGLEWIGSIYYRGSTNYNPSLKSRVTISVDSSKNQFYLKVSSVTAVDTAVYYCARQNGAARPSWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPDTISLSPGERATLSCRASQSISSIYLAWYQQKPGQAPRLLIYGASSRVTGIPDRFSVSGSGTDFTLTISRLEPEDFAVYYCQHYGISPFTFGPGTKVDIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0414", "inn": "Ripertamab", "target": "MS4A1", "target_uniprot": "P11836", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5826", "product_url": "https://ichor.bio/ripertamab-biosimilar-research-grade-ich5826", "rrid": "", "sequences": { "heavy_chain": "QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.57, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0415", "inn": "Rivabazumab", "target": "PcrV protein type III secretion system", "target_uniprot": null, "format": "Fab fragment (1 H-fragment + 1 L)", "isotype": "Fab' - G1 - kappa", "product_sku": "ICH5827", "product_url": "https://ichor.bio/rivabazumab-biosimilar-research-grade-ich5827", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGVVQPGRSLRLSCAASGFTFSNYPMHWVRQAPGKGLEWVAVISYDGSEKWYADSVKGRFTISRDNSKNTLYLEMNSLRPEDTAVYYCARNRGDIYYDFTYAMDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSSDKTHTCPPCPAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSTLSASVGDSVTITCRASEGVDRWLAWYQQKPGRAPKLLIYDASTLQSGVPSRFSGSGSGTEFSLTISSLQPDDVATYYCQHFWGTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGES", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 49.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.14, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0416", "inn": "Roledumab", "target": "RHD", "target_uniprot": "Q02161", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5830", "product_url": "https://ichor.bio/roledumab-biosimilar-research-grade-ich5830", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCTASGFTFKNYAMHWVRQAPAKGLEWVATISYDGRNIQYADSVKGRFTFSRDNSQDTLYLQLNSLRPEDTAVYYCARPVRSRWLQLGLEDAFHIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "AIRMTQSPSSFSASTGDRVTITCRASQDIRNYVAWYQQKSGKAPKFLIYAASTLQSGVPSRFSGSGSGTDFTLTINSLQSEDFATYYCQQYYNSPPTFGQGTRVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.59, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0417", "inn": "Rontalizumab", "target": "IFNA1", "target_uniprot": "P0DY56", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5835", "product_url": "https://ichor.bio/rontalizumab-biosimilar-research-grade-ich5835", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCATSGYTFTEYIIHWVRQAPGKGLEWVASINPDYDITNYNQRFKGRFTISLDKSKRTAYLQMNSLRAEDTAVYYCASWISDFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKVLISYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWGIPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0418", "inn": "Rosmantuzumab", "target": "RSPO3", "target_uniprot": "Q9BXY4", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5836", "product_url": "https://ichor.bio/rosmantuzumab-biosimilar-research-grade-ich5836", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYSIHWVRQAPGQGLEWIGYIYPSNGDSGYNQKFKNRVTMTRDTSTSTAYMELSRLRSEDTAVYYCATYFANNFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQSVDYDGDSYMNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISPVQAEDFATYYCQQSNEDPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0419", "inn": "Samrotamab", "target": "LRRC15", "target_uniprot": "Q8TF66", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5846", "product_url": "https://ichor.bio/samrotamab-biosimilar-research-grade-ich5846", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYKFSSYWIEWVKQAPGQGLEWIGEILPGSDTTNYNEKFKDRATFTSDTSINTAYMELSRLRSDDTAVYYCARDRGNYRAWFGYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGGAVKFLIYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQGEALPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0420", "inn": "Sasanlimab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5848", "product_url": "https://ichor.bio/sasanlimab-biosimilar-research-grade-ich5848", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWINWVRQAPGQGLEWMGNIYPGSSLTNYNEKFKNRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARLSTGTFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSLWDSGNQKNFLTWYQQKPGQPPKLLIYWTSYRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYFYPHTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0421", "inn": "Semorinemab", "target": "MAPT", "target_uniprot": "P10636", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5850", "product_url": "https://ichor.bio/semorinemab-biosimilar-research-grade-ich5850", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGLIFRSYGMSWVRQAPGKGLEWVATINSGGTYTYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCANSYSGAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DDVLTQTPLSLPVTPGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSLVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.81, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0422", "inn": "Serclutamab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5853", "product_url": "https://ichor.bio/serclutamab-biosimilar-research-grade-ich5853", "rrid": "", "sequences": { "heavy_chain": "EVQLQESGPGLVKPSQTLSLTCTVSGYSISRDFAWNWIRQPPGKGLEWMGYISYNGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTASRGFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSMSVSVGDRVTITCHSSQDINSNIGWLQQKPGKSFKGLIYHGTNLDDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCVQYAQFPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.31, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0423", "inn": "Seribantumab", "target": "ERBB3", "target_uniprot": "P21860", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5854", "product_url": "https://ichor.bio/seribantumab-biosimilar-research-grade-ich5854", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYVMAWVRQAPGKGLEWVSSISSSGGWTLYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGLKMATIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSALTQPASVSGSPGQSITISCTGTSSDVGSYNVVSWYQQHPGKAPKLIIYEVSQRPSGVSNRFSGSKSGNTASLTISGLQTEDEADYYCCSYAGSSIFVIFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.17, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0424", "inn": "Serplulimab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5855", "product_url": "https://ichor.bio/serplulimab-biosimilar-research-grade-ich5855", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGLVKPGGSLRLSCAASGFTFSNYGMSWIRQAPGKGLEWVSTISGGGSNIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCVSYYYGIDFWGQGTSVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVTTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHYTIPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0425", "inn": "Setoxaximab", "target": "shiga toxin type 2", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5856", "product_url": "https://ichor.bio/setoxaximab-biosimilar-research-grade-ich5856", "rrid": "", "sequences": { "heavy_chain": "EVQLQQPGPELEKPGASVKLSCKASGYSFTDYNMNWVKQNNGESLEWIGKIDPYYGGPSYNQKFKDKATLTVDKSSSTAYMQLKSLTSEDSAVYYCTRGGNRDWYFDVWGAGTTLTVSAEFASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVLSQSPSSLVVSVGEKVTMSCKSSQSLLYSRNQKNYLAWYQQKPGQSPKVLIYWASTRESGVPDRLTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.04, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0426", "inn": "Setrusumab", "target": "SOST", "target_uniprot": "Q9BQB4", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5857", "product_url": "https://ichor.bio/setrusumab-biosimilar-research-grade-ich5857", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGLVQPGGSLRLSCAASGFTFRSHWLSWVRQAPGKGLEWVSNINYDGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDTYLHFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIALTQPASVSGSPGQSITISCTGTSSDVGDINDVSWYQQHPGKAPKLMIYDVNNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCQSYAGSYLSEVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.69, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0427", "inn": "Sirtratumab", "target": "SLITRK6", "target_uniprot": "Q9H5Y7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5868", "product_url": "https://ichor.bio/sirtratumab-biosimilar-research-grade-ich5868", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNQYYADSVKGRFTISRDNSKNTLFLQMHSLRAEDTAVYYCARGLTSGRYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLLSHGFNYLDWYLQKPGQSPQLLIYLGSSRASGVPDRFSGSGSGTDFTLKISRVEAEDVGLYYCMQPLQIPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0428", "inn": "Sirtratumab Vedotin", "target": "SLITRK6", "target_uniprot": "Q9H5Y7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5868V", "product_url": "https://ichor.bio/sirtratumab-vedotin-biosimilar-research-grade-ich5868v", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNQYYADSVKGRFTISRDNSKNTLFLQMHSLRAEDTAVYYCARGLTSGRYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPLSLPVTPGEPASISCRSSQSLLLSHGFNYLDWYLQKPGQSPQLLIYLGSSRASGVPDRFSGSGSGTDFTLKISRVEAEDVGLYYCMQPLQIPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0429", "inn": "Sirukumab", "target": "IL6", "target_uniprot": "P05231", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5869", "product_url": "https://ichor.bio/sirukumab-biosimilar-research-grade-ich5869", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSPFAMSWVRQAPGKGLEWVAKISPGGSWTYYSDTVTGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLWGYYALDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCSASISVSYMYWYQQKPGQAPRLLIYDMSNLASGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCMQWSGYPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0430", "inn": "Solanezumab", "target": "APP", "target_uniprot": "P05067", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5871", "product_url": "https://ichor.bio/solanezumab-biosimilar-research-grade-ich5871", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYSMSWVRQAPGKGLELVAQINSVGNSTYYPDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCASGDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DVVMTQSPLSLPVTLGQPASISCRSSQSLIYSDGNAYLHWFLQKPGQSPRLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.33, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0431", "inn": "Spartalizumab", "target": "PDCD1", "target_uniprot": "Q15116", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5881", "product_url": "https://ichor.bio/spartalizumab-biosimilar-research-grade-ich5881", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLRISCKGSGYTFTTYWMHWVRQATGQGLEWMGNIYPGTGGSNFDEKFKNRVTITADKSTSTAYMELSSLRSEDTAVYYCTRWTTGTGAYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "EIVLTQSPATLSLSPGERATLSCKSSQSLLDSGNQKNFLTWYQQKPGQAPRLLIYWASTRESGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCQNDYSYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.59, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0432", "inn": "Spesolimab", "target": "IL1RL2", "target_uniprot": "Q9HB29", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5882", "product_url": "https://ichor.bio/spesolimab-biosimilar-research-grade-ich5882", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYSFTSSWIHWVKQAPGQGLEWMGEINPGNVRTNYNENFRNKVTMTVDTSISTAYMELSRLRSDDTAVYYCTVVFYGEPYFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QIVLTQSPGTLSLSPGERATMTCTASSSVSSSYFHWYQQKPGQAPRLWIYRTSRLASGVPDRFSGSGSGTDFTLTISRLEPEDAATYYCHQFHRSPLTFGAGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0433", "inn": "Suptavumab", "target": "RSV", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5887", "product_url": "https://ichor.bio/suptavumab-biosimilar-research-grade-ich5887", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGDLVQPGRSLRLSCVASGFTFDDYAMHWVRQAPGKGLEWVSGVSWSGSTVGYADSVKGRFTVSRDNAQKSLYLQMNSLRAEDTALYYCVKDAYKFNYYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVMTQSPATLSVSPGERATLSCRASQTILSNLAWYLQKPGQAPRLLIYGASTRATGLPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0434", "inn": "Suvizumab", "target": "HIV-1", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5890", "product_url": "https://ichor.bio/suvizumab-biosimilar-research-grade-ich5890", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQRPDSLSASVGDRVTMSCKSSQSLLNSGDQKNYLTWYQQKPGQPPKLLIYWASTGESGVPDRFSGSGSGTDFTFTISSLQPEDIATYYCQNDYSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0435", "inn": "Suvratoxumab", "target": "alpha toxin", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5891", "product_url": "https://ichor.bio/suvratoxumab-biosimilar-research-grade-ich5891", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSHDMHWVRQATGKGLEWVSGIGTAGDTYYPDSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARDRYSPTGHYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCKQYADYWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0436", "inn": "Tabituximab", "target": "FZD10", "target_uniprot": "Q9ULW2", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5892", "product_url": "https://ichor.bio/tabituximab-biosimilar-research-grade-ich5892", "rrid": "", "sequences": { "heavy_chain": "EVQLQQSGAELVKPGASVKLSCTASGFNINDTYMHWVKQRPEQGLEWIGRIDPANGNTKYDPKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCARGARGSRFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPASLSVSVGETVTITCRASENIYSNLAWYQQKQGKSPQLLVYVATNLADGVPSRFSGSGSGTQYSLKINSLQSEDFGSYYCQHFWGTPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0437", "inn": "Tadocizumab", "target": "ITGA2B_ITGB3", "target_uniprot": "P08514;P05106", "format": "Fab fragment (1 H-fragment + 1 L)", "isotype": "Fab - G1 - kappa", "product_sku": "ICH5893", "product_url": "https://ichor.bio/tadocizumab-biosimilar-research-grade-ich5893", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYAFTNYLIEWVRQAPGQGLEWIGVIYPGSGGTNYNEKFKGRVTLTVDESTNTAYMELSSLRSEDTAVYFCARRDGNYGWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQTPSTLSASVGDRVTISCRASQDINNYLNWYQQKPGKAPKLLIYYTSTLHSGVPSRFSGSGSGTDYTLTISSLQPDDFATYFCQQGNTLPWTFGQGTKVEVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 47.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.5, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0438", "inn": "Tafolecimab", "target": "PCSK9", "target_uniprot": "Q8NBP7", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5894", "product_url": "https://ichor.bio/tafolecimab-biosimilar-research-grade-ich5894", "rrid": "", "sequences": { "heavy_chain": "QLQLQESGPGLVKPSETLSLTCTVSGGSISSASYYWSWIRQPPGKGLEWIGSINYRGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARENSGVVPAAGPNWFGPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRRNWFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.05, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0439", "inn": "Talacotuzumab", "target": "IL3RA", "target_uniprot": "P26951", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5896", "product_url": "https://ichor.bio/talacotuzumab-biosimilar-research-grade-ich5896", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGESLKISCKGSGYSFTDYYMKWARQMPGKGLEWMGDIIPSNGATFYNQKFKGQVTISADKSISTTYLQWSSLKASDTAMYYCARSHLLRASWFAYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKALPAPEEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCESSQSLLNSGNQKNYLTWYQQKPGQPPKPLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0440", "inn": "Tamrintamab", "target": "DPEP3", "target_uniprot": "Q9H4B8", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5898", "product_url": "https://ichor.bio/tamrintamab-biosimilar-research-grade-ich5898", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYWIEWVRQAPGQGLEWMGEILPGSGNTYYNERFKDRVTITADESTSTAYMELSSLRSEDTAVYYCARRAAAYYSNPEWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "EIVLTQSPATLSLSPGERATLSCTASSSVNSFYLHWYQQKPGLAPRLLIYSTSNLASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCHQYHRSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0441", "inn": "Tamtuvetmab", "target": "CD52", "target_uniprot": "Q28896", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - Vkappa-Clambda", "product_sku": "ICH5899", "product_url": "https://ichor.bio/tamtuvetmab-biosimilar-research-grade-ich5899", "rrid": "", "sequences": { "heavy_chain": "EVKLLESGGGLVQPGGSMRLSCAGSGFTFTDFYMNWIRQPAGKAPEWLGFIRDKAKGYTTEYNPSVKGRFTISRDNTQNMLYLQMNTLRAEDTATYYCAREGHTAAPFDYWGQGTLVTVSSASTTAPSVFPLAPSCGSTSGSTVALACLVSGYFPEPVTVSWNSGSLTSGVHTFPSVLQSSGLYSLSSMVTVPSSRWPSETFTCNVAHPASKTKVDKPVPKRENGRVPRPPDCPKCPAPEMLGGPSVFIFPPKPKDTLLIARTPEVTCVVVDLDPEDPEVQISWFVDGKQMQTAKTQPREEQFNGTYRVVSVLPIGHQDWLKGKQFTCKVNNKALPSPIERTISKARGQAHQPSVYVLPPSREELSKNTVSLTCLIKDFFPPDIDVEWQSNGQQEPESKYRTTPPQLDEDGSYFLYSKLSVDKSRWQRGDTFICAVMHEALHNHYTQKSLSHSPGK", "light_chain": "DIKMTQSPSFLSASVGDRVTLNCKASQNIDKYLNWYQQKLGESPKLLIYNTNNLQTGIPSRFSGSGSGTDFTLTISSLQPEDVATYFCLQHISRPRTFGGGTHLTVLGQPKASPSVTLFPPSSEELGANKATLVCLISDFYPSGVTVAWKADGSPITQGVETTKPSKQSNNKYAASSYLSLTPDKWKSHSSFSCLVTHEGSTVEKKVAPAECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.35, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0442", "inn": "Tarextumab", "target": "NOTCH2", "target_uniprot": "Q04721", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5902", "product_url": "https://ichor.bio/tarextumab-biosimilar-research-grade-ich5902", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSGMSWVRQAPGKGLEWVSVIASSGSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSIFYTTWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVLTQSPATLSLSPGERATLSCRASQSVRSNYLAWYQQKPGQAPRLLIYGASSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNFPITFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.05, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0443", "inn": "Tavolimab", "target": "TNFRSF4", "target_uniprot": "P43489", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5903", "product_url": "https://ichor.bio/tavolimab-biosimilar-research-grade-ich5903", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSQTLSLTCAVYGGSFSSGYWNWIRKHPGKGLEYIGYISYNGITYHNPSLKSRITINRDTSKNQYSLQLNSVTPEDTAVYYCARYKYDYDGGHAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGSALPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.4, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0444", "inn": "Telazorlimab", "target": "TNFRSF4", "target_uniprot": "P43489", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5909", "product_url": "https://ichor.bio/telazorlimab-biosimilar-research-grade-ich5909", "rrid": "", "sequences": { "heavy_chain": "QVTLKESGPALVKPTQTLTLTCSFSGFSLSTSGMGVGWIRQPPGKALEWIAHIWWDDDKYYNTALKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARIDWDGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASSSVSYMHWYQQKPGQAPRPWIYATSNRATGIPARFSGSGSGTDYTLTISSLEPEDFAVYYCQQWSSNPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.07, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0445", "inn": "Temelimab", "target": "endogenous retrovirus", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5912", "product_url": "https://ichor.bio/temelimab-biosimilar-research-grade-ich5912", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDYEMHWVRQAPGQGLEWIGAVAPETGGTAYNQKFKGRATITADKSTSTAYMELSSLRSEDTAVYYCTSTVVPFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "QIQLTQSPSSLSASVGDRVTITCSASSSVSYMYWYQQKPGKAPKAWIYRTSNLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQYQSLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0446", "inn": "Tenatumomab", "target": "TNC", "target_uniprot": "P24821", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2b - kappa", "product_sku": "ICH5914", "product_url": "https://ichor.bio/tenatumomab-biosimilar-research-grade-ich5914", "rrid": "", "sequences": { "heavy_chain": "EIQLQQSGPELVKPGASVKVSCKASGYAFTSYNMYWVKQSHGKSLEWIGYIDPYNGVTSYNQKFKGKATLTVDKSSSTAYMHLNSLTSEDSAVYYCARGGGSIYYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGK", "light_chain": "DIVMTQAAPSVPVTPGESVSISCRSSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLRISRVEAEDVGVYYCMQHLEYPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0447", "inn": "Tesidolumab", "target": "C5", "target_uniprot": "P01031", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5918", "product_url": "https://ichor.bio/tesidolumab-biosimilar-research-grade-ich5918", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIGPFFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARDTPYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "SYELTQPLSVSVALGQTARITCSGDSIPNYYVYWYQQKPGQAPVLVIYDDSNRPSGIPERFSGSNSGNTATLTISRAQAGDEADYYCQSFDSSLNAEVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.84, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0448", "inn": "Tesnatilimab", "target": "KLRK1", "target_uniprot": "P26718", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5919", "product_url": "https://ichor.bio/tesnatilimab-biosimilar-research-grade-ich5919", "rrid": "", "sequences": { "heavy_chain": "QVHLQESGPGLVKPSETLSLTCTVSDDSISSYYWSWIRQPPGKGLEWIGHISYSGSANYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCANWDDAFNIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.63, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0449", "inn": "Tifcemalimab", "target": "BTLA", "target_uniprot": "Q7Z6A9", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5920", "product_url": "https://ichor.bio/tifcemalimab-biosimilar-research-grade-ich5920", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKLSCKASGYNFKHTYAHWVRQAPGQGLEWIGRIDPANGNTKYDPKFQGRATMTADTASNTAYLELSSLRSEDTAVYYCVADHYGSSLLDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DVVMTQTPLSLSVTPGQPASISCKSSQSLLDSDGKTYLNWFQQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTYFPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0450", "inn": "Tigatuzumab", "target": "TNFRSF10B", "target_uniprot": "O14763", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5921", "product_url": "https://ichor.bio/tigatuzumab-biosimilar-research-grade-ich5921", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARRGDSMITTDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSYRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0451", "inn": "Tilogotamab", "target": "TNFRSF10B", "target_uniprot": "O14763", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5922", "product_url": "https://ichor.bio/tilogotamab-biosimilar-research-grade-ich5922", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGFNIKDTHMHWVRQAPGQRLEWIGRIDPANGNTEYDQKFQGRVTITVDTSASTAYMELSSLRSEDTAVYYCARWGTNVYFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHGALHNHYTQKSLSLSPG", "light_chain": "DIQLTQSPSSLSASVGDRVTITCSASSSVSYMYWYQQKPGKAPKPWIYRTSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYHSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0452", "inn": "Timigutuzumab", "target": "ERBB2", "target_uniprot": "P04626", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5925", "product_url": "https://ichor.bio/timigutuzumab-biosimilar-research-grade-ich5925", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.32, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0453", "inn": "Timolumab", "target": "AOC3", "target_uniprot": "Q16853", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5926", "product_url": "https://ichor.bio/timolumab-biosimilar-research-grade-ich5926", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFFSYAMHWVRQTPGKGLEWVAVIWFDGSNENYVDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDAWSYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "VIQLTQSPSSLSASVGDRVTITCRASQGISRALAWYQQKPGKGPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0454", "inn": "Tomaralimab", "target": "TLR2", "target_uniprot": "O60603", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5932", "product_url": "https://ichor.bio/tomaralimab-biosimilar-research-grade-ich5932", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGSELKKPGASVKLSCKASGFTFTTYGINWVRQAPGQGLEWIGWIYPRDGSTNFNENFKDRATITVDTSASTAYMELSSLRSEDTAVYFCARLTGGTFLDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIVLTQSPATLSLSPGERATLSCRASESVEYYGTSLMQWYQQKPGQPPKLLIFGASNVESGVPDRFSGSGSGTDFTLKISRVEAEDVGMYFCQQSRKLPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.56, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0455", "inn": "Tomuzotuximab", "target": "EGFR", "target_uniprot": "P00533", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5933", "product_url": "https://ichor.bio/tomuzotuximab-biosimilar-research-grade-ich5933", "rrid": "", "sequences": { "heavy_chain": "QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSTASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEGLHNHYTQKSLSLSPG", "light_chain": "DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.9, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0456", "inn": "Tosatoxumab", "target": "alpha toxin", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda", "product_sku": "ICH5936", "product_url": "https://ichor.bio/tosatoxumab-biosimilar-research-grade-ich5936", "rrid": "", "sequences": { "heavy_chain": "EVQMVQSGAEVKKPGEPLKISCKGSGYKFGTHWIGWVRQRPGKGLEWMGIIHPADSETKYSPSFQGQVSFSADKSSNTAYLHWSTLRASDTAMYYCARRSGSSSWYALDFWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "QSVLTQSPSASGTPGQRVTISCSGGSSNIGSNTVNWYQQFPGAAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGLYVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.51, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0457", "inn": "Tregalizumab", "target": "CD4", "target_uniprot": "P01730", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5942", "product_url": "https://ichor.bio/tregalizumab-biosimilar-research-grade-ich5942", "rrid": "", "sequences": { "heavy_chain": "EEQLVESGGGLVKPGGSLRLSCAASGFSFSDCRMYWLRQAPGKGLEWIGVISVKSENYGANYAESVRGRFTISRDDSKNTVYLQMNSLKTEDTAVYYCSASYYRYDVGAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSYIYWYQQKPGQPPKLLIYLASILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRELPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.66, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0458", "inn": "Trevogrumab", "target": "MSTN", "target_uniprot": "O14793", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5943", "product_url": "https://ichor.bio/trevogrumab-biosimilar-research-grade-ich5943", "rrid": "", "sequences": { "heavy_chain": "EVQVLESGGDLVQPGGSLRLSCAASGFTFSAYAMTWVRQAPGKGLEWVSAISGSGGSAYYADSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAKDGAWKMSGLDVWGQGTTVIVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DIQMTQSPASLSASVGDRVTITCRASQDISDYLAWYQQKPGKIPRLLIYTTSTLQSGVPSRFRGSGSGTDFTLTISSLQPEDVATYYCQKYDSAPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0459", "inn": "Ulocuplumab", "target": "CXCR4", "target_uniprot": "P61073", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5954", "product_url": "https://ichor.bio/ulocuplumab-biosimilar-research-grade-ich5954", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAAAGFTFSSYSMNWVRQAPGKGLEWVSYISSRSRTIYYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARDYGGQPPYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFVTYYCQQYNSYPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.37, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0460", "inn": "Urabrelimab", "target": "CD47", "target_uniprot": "Q08722", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5961", "product_url": "https://ichor.bio/urabrelimab-biosimilar-research-grade-ich5961", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSGTLSLTCAVSGVSIRSINWWNWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLNSVTAADTAVYYCARDGGIAVTDYYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "EIVLTQSPATLSLSPGERATLSCRASESVSSNLAWYQQKPGQAPRLLIYGAFNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSDWFTFGGGTKVEIKTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.09, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0461", "inn": "Vadastuximab", "target": "CD33", "target_uniprot": "P20138", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5964", "product_url": "https://ichor.bio/vadastuximab-biosimilar-research-grade-ich5964", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYDINWVRQAPGQGLEWIGWIYPGDGSTKYNEKFKAKATLTADTSTSTAYMELRSLRSDDTAVYYCASGYEDAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTINCKASQDINSYLSWFQQKPGKAPKTLIYRANRLVDGVPSRFSGSGSGQDYTLTISSLQPEDFATYYCLQYDEFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.65, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0462", "inn": "Vantictumab", "target": "frizzled family receptor", "target_uniprot": null, "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - lambda", "product_sku": "ICH5967", "product_url": "https://ichor.bio/vantictumab-biosimilar-research-grade-ich5967", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSHYTLSWVRQAPGKGLEWVSVISGDGSYTYYADSVKGRFTISSDNSKNTLYLQMNSLRAEDTAVYYCARNFIKYVFANWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIELTQPPSVSVAPGQTARISCSGDNIGSFYVHWYQQKPGQAPVLVIYDKSNRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCQSYANTLSLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 142.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 6.66, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0463", "inn": "Varisacumab", "target": "VEGFA", "target_uniprot": "P15692", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5969", "product_url": "https://ichor.bio/varisacumab-biosimilar-research-grade-ich5969", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGFDPEDGETIYAQKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCATGRSMVRGVIIPFNGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIRMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.89, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0464", "inn": "Vatelizumab", "target": "ITGA2", "target_uniprot": "P17301", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH5970", "product_url": "https://ichor.bio/vatelizumab-biosimilar-research-grade-ich5970", "rrid": "", "sequences": { "heavy_chain": "QVQLQESGPGLVKPSETLSLTCTVSGFSLTNYGIHWIRQPPGKGLEWLGVIWARGFTNYNSALMSRLTISKDNSKNQVSLKLSSVTAADTAVYYCARANDGVYYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DFVMTQSPAFLSVTPGEKVTITCSAQSSVNYIHWYQQKPDQAPKKLIYDTSKLASGVPSRFSGSGSGTDYTFTISSLEAEDAATYYCQQWTTNPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.1, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0465", "inn": "Vesencumab", "target": "NRP1", "target_uniprot": "O14786", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5977", "product_url": "https://ichor.bio/vesencumab-biosimilar-research-grade-ich5977", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSQISPAGGYTNYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARGELPYYRMSKVMDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQYFSSYLAWYQQKPGKAPKLLIYGASSRASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLGSPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0466", "inn": "Vofatamab", "target": "FGFR3", "target_uniprot": "P22607", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5986", "product_url": "https://ichor.bio/vofatamab-biosimilar-research-grade-ich5986", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFTSTGISWVRQAPGKGLEWVGRIYPTSGSTNYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARTYGIYDLYVDYTEYVMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDVDTSLAWYKQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGHPQTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0467", "inn": "Volagidemab", "target": "GCGR", "target_uniprot": "P47871", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG2 - kappa", "product_sku": "ICH5987", "product_url": "https://ichor.bio/volagidemab-biosimilar-research-grade-ich5987", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVMWYDGSNKDYVDSVKGRFTISRDNSKNTLYLQMNRLRAEDTAVYYCAREKDHYDILTGYNYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSVQPEDFVTYYCLQHNSNPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 147.0, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.04, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0468", "inn": "Vonlerolizumab", "target": "TNFRSF4", "target_uniprot": "P43489", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5989", "product_url": "https://ichor.bio/vonlerolizumab-biosimilar-research-grade-ich5989", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTDSYMSWVRQAPGQGLEWIGDMYPDNGDSSYNQKFRERVTITRDTSTSTAYLELSSLRSEDTAVYYCVLAPRWYFSVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLRSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGHTLPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.3, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.2, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0469", "inn": "Vopratelimab", "target": "ICOS", "target_uniprot": "Q9Y6W8", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5991", "product_url": "https://ichor.bio/vopratelimab-biosimilar-research-grade-ich5991", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYWMDWVRQAPGKGLVWVSNIDEDGSITEYSPFVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCTRWGRFGFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCKSSQSLLSGSFNYLTWYQQKPGQPPKLLIFYASTRHTGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCHHHYNAPPTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.44, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0470", "inn": "Vorsetuzumab", "target": "CD70", "target_uniprot": "P32970", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5992", "product_url": "https://ichor.bio/vorsetuzumab-biosimilar-research-grade-ich5992", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLKWMGWINTYTGEPTYADAFKGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARDYGDYGMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSREVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0471", "inn": "Vorsetuzumab Mafodotin", "target": "TNFSF7 / CD27L / CD70", "target_uniprot": "P32970", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1", "product_sku": "ICH5992M", "product_url": "https://ichor.bio/vorsetuzumab-mafodotin-biosimilar-research-grade-ich5992m", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLKWMGWINTYTGEPTYADAFKGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARDYGDYGMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSREVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.1, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.06, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0472", "inn": "Vunakizumab", "target": "IL17A", "target_uniprot": "Q16552", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5995", "product_url": "https://ichor.bio/vunakizumab-biosimilar-research-grade-ich5995", "rrid": "", "sequences": { "heavy_chain": "EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEVHWVRQAPGQGLEWMGVIDPGTGGVAYNQKFEGRVTMTADTSTSTAYMELRSLRSDDTAVYYCTRYSLFYGSSPYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPDFQSVTPKEKVTITCSASSSVNYMHWFQQKPDQSPKLWIYRTSNLASGVPSRFSGSGSGTDYTLTINSLEAEDAATYYCQQRSSYPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.41, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0473", "inn": "Xentuzumab", "target": "IGF2", "target_uniprot": "P01344", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - lambda2", "product_sku": "ICH5996", "product_url": "https://ichor.bio/xentuzumab-biosimilar-research-grade-ich5996", "rrid": "", "sequences": { "heavy_chain": "QVELVESGGGLVQPGGSLRLSCAASGFTFTSYWMSWVRQAPGKGLELVSSITSYGSFTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARNMYTHFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVLTQPPSVSGAPGQRVTISCSGSSSNIGSNSVSWYQQLPGTAPKLLIYDNSKRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCQSRDTYGYYWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKGDSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.7, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.21, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0474", "inn": "Zalifrelimab", "target": "CTLA4", "target_uniprot": "P16410", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH5998", "product_url": "https://ichor.bio/zalifrelimab-biosimilar-research-grade-ich5998", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVGLMGPFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "EIVLTQSPGTLSLSPGERATLSCRASQSVSRYLGWYQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTDFTLTITRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 144.6, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.43, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0475", "inn": "Zampilimab", "target": "TGM2", "target_uniprot": "P21980", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG4 - kappa", "product_sku": "ICH6001", "product_url": "https://ichor.bio/zampilimab-biosimilar-research-grade-ich6001", "rrid": "", "sequences": { "heavy_chain": "EVQLLESGGGLVQPGGSLRLSCAASGFTLSTHAMSWVRQAPGKGLEWVATISSGGRSTYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARLISTYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK", "light_chain": "DITMTQSPSSLSASVGDRVTITCKASQDINSYLTWFQQKPGKAPKILIYLVNRLVDGVPSRFSGSGSGQDYALTISSLQPEDFATYYCLQYDDFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 143.5, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.39, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0476", "inn": "Zanidatamab", "target": "ERBB2", "target_uniprot": "P04626", "format": "bispecific / multi-chain (3 chains)", "isotype": "half-IG G1 - kappa / (scFv - kappa - heavy) -h-CH2-CH3", "product_sku": "ICH6002", "product_url": "https://ichor.bio/zanidatamab-biosimilar-research-grade-ich6002", "rrid": "", "sequences": { "heavy_chain": "GEVQLVESGGGLVQPGGSLRLSCAASGFTFADYTMDWVRQAPGKGLEWVGDVNPNSGGSIYNQRFKGRFTFSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYVYPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFALVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "GDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGGSGGGSGGGSGGGSGGGSGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSAAEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYVLPPSRDELTKNQVSLLCLVKGFYPSDIAVEWESNGQPENNYLTWPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 124.8, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.92, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 98.138, "unit": "%", "method": "SEC-HPLC (supplier CoA, 98.138% main peak)" } ] }, { "entry_id": "ICB-BSR-0477", "inn": "Zelminemab", "target": "ADCYAP1R1", "target_uniprot": "P41586", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH6005", "product_url": "https://ichor.bio/zelminemab-biosimilar-research-grade-ich6005", "rrid": "", "sequences": { "heavy_chain": "QVQLVESGAEVVKPGASVKVSCKASGFTFSRFAMHWVRQAPGQGLEWMGVISYDGGNKYYAESVKGRVTMTRDTSTSTLYMELSSLRSEDTAVYYCARGYDVLTGYPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYGSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQLTQSPSFLSASVGDRVTITCRASQSIGRSLHWYQQKPGKAPKLLIKYASQSLSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCHQSSRLPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.5, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0478", "inn": "Ziltivekimab", "target": "IL6", "target_uniprot": "P05231", "format": "standard IgG (2H+2L, theoretical from sequence)", "isotype": "IgG1 - kappa", "product_sku": "ICH6008", "product_url": "https://ichor.bio/ziltivekimab-biosimilar-research-grade-ich6008", "rrid": "", "sequences": { "heavy_chain": "EVQLVESGGGLVQPGGSLRLSCAASGFTISSNYMIWVRQAPGKGLEWVSDLYYYAGDTYYADSVKGRFTMSRDISKNTVYLQMNSLRAEDTAVYYCARWADDHPPWIDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIQMTQSPSTLSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKVLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQSWLGGSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.4, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.67, "unit": "pH units", "method": "theoretical (from sequence)" } ] }, { "entry_id": "ICB-BSR-0479", "inn": "Zenocutuzumab", "target": null, "target_uniprot": null, "format": "bispecific / multi-chain (4 chains)", "isotype": "IgG1 - kappa", "product_sku": "ICH6013", "product_url": "https://ichor.bio/zenocutuzumab-biosimilar-research-grade-ich6013", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKLSCKASGYTFTAYYINWVRQAPGQGLEWIGRIYPGSGYTSYAQKFQGRATLTADESTSTAYMELSSLRSEDTAVYFCARPPVYYDSAWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTDPPSREEMTKNQVSLTCEVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG", "light_chain": "DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 145.9, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 8.42, "unit": "pH units", "method": "theoretical (from sequence)" }, { "parameter": "pct_monomer", "value": 100.0, "unit": "%", "method": "SEC-HPLC (supplier CoA, 100% main peak)" } ] }, { "entry_id": "ICB-BSR-0480", "inn": "Navicixizumab", "target": "VEGFA + DLL4", "target_uniprot": "P15692;Q9NR61", "format": "bispecific / multi-chain (4 chains)", "isotype": "IgG2 - kappa", "product_sku": "ICH6020", "product_url": "https://ichor.bio/navicixizumab-biosimilar-research-grade", "rrid": "", "sequences": { "heavy_chain": "QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWMHWVRQAPGQGLEWMGDINPSNGRTSYKEKFKRRVTLSVDKSSSTAYMELSSLRSEDTAVYFCTIHYDDKYYPLMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREKMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLKSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "light_chain": "DIVMTQSPDSLAVSLGERATISCRASESVDNYGISFMKWFQQKPGQPPKLLIYAASNQGSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEVPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC", "source": "IMGT/mAb-DB" }, "measurements": [ { "parameter": "mw_kda", "value": 146.2, "unit": "kDa", "method": "theoretical (from sequence)" }, { "parameter": "theoretical_pi", "value": 7.25, "unit": "pH units", "method": "theoretical (from sequence)" } ] } ] }