diff --git a/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_analyze.log b/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_analyze.log new file mode 100644 index 0000000000000000000000000000000000000000..b65587eba10bed0980c4542c0fa526dcec21bf6d --- /dev/null +++ b/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_analyze.log @@ -0,0 +1,722 @@ + arm state thin gen obs_thinned obs_native_n gen_pct obs_pct gen_over_obs spearman_donors + zs__raw C1Q-high monocyte (reference) 0.421 63 / 45,474 5,908 / 111,269 6788 0.139 5.310 0.026 0.149 + zs__raw Cycling T/NK 0.419 294 / 54,913 2,232 / 345,949 3461 0.535 0.645 0.830 0.119 + zs__raw Cycling activated T (CD38/HLA-DR) 0.441 168 / 43,347 3,198 / 298,117 5877 0.388 1.073 0.361 0.034 + zs__raw Proliferating T (label) 1.000 1,369 / 43,347 4,793 / 298,117 4793 3.158 1.608 1.964 -0.019 + zs__raw Plasmablast (label) 1.000 678 / 123,000 8,423 / 589,478 8423 0.551 1.429 0.386 0.332 + zs__raw Plasmablast (markers) 0.495 882 / 123,000 15,275 / 589,478 26774 0.717 2.591 0.277 0.376 + zs__raw MS1 monocyte (IL1R2+) 0.421 403 / 45,474 12,363 / 111,269 18712 0.886 11.111 0.080 0.526 + zs__raw Cycling monocyte (Ye 2026) 0.421 103 / 45,474 2,618 / 111,269 4601 0.227 2.353 0.096 0.191 + zs__raw ISG-high monocyte (positive control) 0.421 8,106 / 45,474 11,029 / 111,269 21377 17.826 9.912 1.798 0.496 + zs__raw ISG-high T 0.441 1,144 / 43,347 4,514 / 298,117 10685 2.639 1.514 1.743 0.432 + zs__raw DN2 / ABC B 0.575 710 / 18,316 2,592 / 99,729 4309 3.876 2.599 1.491 0.105 + zs__raw HSPC 0.495 72 / 123,000 629 / 589,478 741 0.059 0.107 0.549 -0.006 + zs__raw Cytotoxic CD4 T 0.619 85 / 15,654 1,767 / 140,213 2091 0.543 1.260 0.431 0.375 + zs__raw Granulocyte-like (LDG) 0.495 321 / 123,000 6,501 / 589,478 14337 0.261 1.103 0.237 0.417 + zs__raw Platelet signal in monocytes (negative control) 0.421 1,308 / 45,474 11,518 / 111,269 23329 2.876 10.351 0.278 0.234 + xcalL_K1000 C1Q-high monocyte (reference) 0.799 143 / 32,496 6,578 / 111,269 6788 0.440 5.912 0.074 0.112 + xcalL_K1000 Cycling T/NK 0.769 280 / 69,407 3,048 / 345,949 3461 0.403 0.881 0.458 0.163 + xcalL_K1000 Cycling activated T (CD38/HLA-DR) 0.779 230 / 57,613 4,851 / 298,117 5877 0.399 1.627 0.245 0.134 + xcalL_K1000 Proliferating T (label) 1.000 595 / 57,613 4,793 / 298,117 4793 1.033 1.608 0.642 0.081 + xcalL_K1000 Plasmablast (label) 1.000 1,369 / 123,000 8,423 / 589,478 8423 1.113 1.429 0.779 0.413 + xcalL_K1000 Plasmablast (markers) 0.828 1,753 / 123,000 22,886 / 589,478 26774 1.425 3.882 0.367 0.489 + xcalL_K1000 MS1 monocyte (IL1R2+) 0.799 3,632 / 32,496 17,185 / 111,269 18712 11.177 15.445 0.724 0.647 + xcalL_K1000 Cycling monocyte (Ye 2026) 0.799 293 / 32,496 3,975 / 111,269 4601 0.902 3.572 0.252 0.417 + xcalL_K1000 ISG-high monocyte (positive control) 0.799 7,586 / 32,496 18,301 / 111,269 21377 23.344 16.448 1.419 0.501 + xcalL_K1000 ISG-high T 0.779 2,550 / 57,613 8,275 / 298,117 10685 4.426 2.776 1.595 0.552 + xcalL_K1000 DN2 / ABC B 0.987 226 / 17,472 4,260 / 99,729 4309 1.293 4.272 0.303 -0.063 + xcalL_K1000 HSPC 0.828 248 / 123,000 707 / 589,478 741 0.202 0.120 1.681 0.133 + xcalL_K1000 Cytotoxic CD4 T 0.919 457 / 15,566 2,034 / 140,213 2091 2.936 1.451 2.024 0.490 + xcalL_K1000 Granulocyte-like (LDG) 0.828 156 / 123,000 11,842 / 589,478 14337 0.127 2.009 0.063 0.308 + xcalL_K1000 Platelet signal in monocytes (negative control) 0.799 1,074 / 32,496 19,698 / 111,269 23329 3.305 17.703 0.187 0.220 + locoL_lora16sat_s26750_K1000 C1Q-high monocyte (reference) 0.398 41 / 22,524 5,862 / 111,269 6788 0.182 5.268 0.035 0.018 + locoL_lora16sat_s26750_K1000 Cycling T/NK 0.576 76 / 66,367 2,628 / 345,949 3461 0.115 0.760 0.151 -0.128 + locoL_lora16sat_s26750_K1000 Cycling activated T (CD38/HLA-DR) 0.601 69 / 51,586 4,069 / 298,117 5877 0.134 1.365 0.098 -0.082 + locoL_lora16sat_s26750_K1000 Proliferating T (label) 1.000 654 / 51,586 4,793 / 298,117 4793 1.268 1.608 0.789 0.068 + locoL_lora16sat_s26750_K1000 Plasmablast (label) 1.000 2,420 / 123,000 8,423 / 589,478 8423 1.967 1.429 1.377 0.356 + locoL_lora16sat_s26750_K1000 Plasmablast (markers) 0.577 2,799 / 123,000 17,094 / 589,478 26774 2.276 2.900 0.785 0.478 + locoL_lora16sat_s26750_K1000 MS1 monocyte (IL1R2+) 0.398 292 / 22,524 11,961 / 111,269 18712 1.296 10.750 0.121 0.400 + locoL_lora16sat_s26750_K1000 Cycling monocyte (Ye 2026) 0.398 32 / 22,524 2,531 / 111,269 4601 0.142 2.275 0.062 0.034 + locoL_lora16sat_s26750_K1000 ISG-high monocyte (positive control) 0.398 2,818 / 22,524 10,616 / 111,269 21377 12.511 9.541 1.311 0.422 + locoL_lora16sat_s26750_K1000 ISG-high T 0.601 1,839 / 51,586 6,395 / 298,117 10685 3.565 2.145 1.662 0.533 + locoL_lora16sat_s26750_K1000 DN2 / ABC B 0.646 144 / 28,860 2,881 / 99,729 4309 0.499 2.889 0.173 0.109 + locoL_lora16sat_s26750_K1000 HSPC 0.577 223 / 123,000 661 / 589,478 741 0.181 0.112 1.617 0.068 + locoL_lora16sat_s26750_K1000 Cytotoxic CD4 T 0.691 340 / 18,454 1,833 / 140,213 2091 1.842 1.307 1.409 0.541 + locoL_lora16sat_s26750_K1000 Granulocyte-like (LDG) 0.577 17 / 123,000 7,951 / 589,478 14337 0.014 1.349 0.010 -0.063 + locoL_lora16sat_s26750_K1000 Platelet signal in monocytes (negative control) 0.398 411 / 22,524 11,037 / 111,269 23329 1.825 9.919 0.184 0.148 + locoL_lora64sat_s59000_K1000 C1Q-high monocyte (reference) 0.376 59 / 20,054 5,796 / 111,269 6788 0.294 5.209 0.056 0.055 + locoL_lora64sat_s59000_K1000 Cycling T/NK 0.516 76 / 62,886 2,433 / 345,949 3461 0.121 0.703 0.172 -0.160 + locoL_lora64sat_s59000_K1000 Cycling activated T (CD38/HLA-DR) 0.539 83 / 47,130 3,740 / 298,117 5877 0.176 1.255 0.140 0.084 + locoL_lora64sat_s59000_K1000 Proliferating T (label) 1.000 786 / 47,130 4,793 / 298,117 4793 1.668 1.608 1.037 0.138 + locoL_lora64sat_s59000_K1000 Plasmablast (label) 1.000 1,775 / 123,000 8,423 / 589,478 8423 1.443 1.429 1.010 0.375 + locoL_lora64sat_s59000_K1000 Plasmablast (markers) 0.515 2,244 / 123,000 15,686 / 589,478 26774 1.824 2.661 0.686 0.439 + locoL_lora64sat_s59000_K1000 MS1 monocyte (IL1R2+) 0.376 235 / 20,054 11,572 / 111,269 18712 1.172 10.400 0.113 0.419 + locoL_lora64sat_s59000_K1000 Cycling monocyte (Ye 2026) 0.376 31 / 20,054 2,455 / 111,269 4601 0.155 2.206 0.070 0.097 + locoL_lora64sat_s59000_K1000 ISG-high monocyte (positive control) 0.376 2,640 / 20,054 10,099 / 111,269 21377 13.164 9.076 1.450 0.487 + locoL_lora64sat_s59000_K1000 ISG-high T 0.539 1,710 / 47,130 5,613 / 298,117 10685 3.628 1.883 1.927 0.514 + locoL_lora64sat_s59000_K1000 DN2 / ABC B 0.541 152 / 33,758 2,472 / 99,729 4309 0.450 2.479 0.182 0.315 + locoL_lora64sat_s59000_K1000 HSPC 0.515 393 / 123,000 637 / 589,478 741 0.320 0.108 2.957 0.096 + locoL_lora64sat_s59000_K1000 Cytotoxic CD4 T 0.622 372 / 17,818 1,721 / 140,213 2091 2.088 1.227 1.701 0.581 + locoL_lora64sat_s59000_K1000 Granulocyte-like (LDG) 0.515 23 / 123,000 6,864 / 589,478 14337 0.019 1.164 0.016 0.143 + locoL_lora64sat_s59000_K1000 Platelet signal in monocytes (negative control) 0.376 342 / 20,054 10,482 / 111,269 23329 1.705 9.420 0.181 0.357 + locoL_fullsat_s20000_K1000 C1Q-high monocyte (reference) 0.338 103 / 24,002 5,654 / 111,269 6788 0.429 5.081 0.084 0.084 + locoL_fullsat_s20000_K1000 Cycling T/NK 0.570 170 / 64,082 2,639 / 345,949 3461 0.265 0.763 0.348 0.096 + locoL_fullsat_s20000_K1000 Cycling activated T (CD38/HLA-DR) 0.619 142 / 49,480 4,135 / 298,117 5877 0.287 1.387 0.207 0.232 + locoL_fullsat_s20000_K1000 Proliferating T (label) 1.000 862 / 49,480 4,793 / 298,117 4793 1.742 1.608 1.084 0.074 + locoL_fullsat_s20000_K1000 Plasmablast (label) 1.000 3,117 / 123,000 8,423 / 589,478 8423 2.534 1.429 1.774 0.330 + locoL_fullsat_s20000_K1000 Plasmablast (markers) 0.544 3,756 / 123,000 16,338 / 589,478 26774 3.054 2.772 1.102 0.435 + locoL_fullsat_s20000_K1000 MS1 monocyte (IL1R2+) 0.338 679 / 24,002 10,777 / 111,269 18712 2.829 9.686 0.292 0.543 + locoL_fullsat_s20000_K1000 Cycling monocyte (Ye 2026) 0.338 73 / 24,002 2,253 / 111,269 4601 0.304 2.025 0.150 0.138 + locoL_fullsat_s20000_K1000 ISG-high monocyte (positive control) 0.338 2,727 / 24,002 9,217 / 111,269 21377 11.362 8.284 1.372 0.432 + locoL_fullsat_s20000_K1000 ISG-high T 0.619 1,469 / 49,480 6,546 / 298,117 10685 2.969 2.196 1.352 0.443 + locoL_fullsat_s20000_K1000 DN2 / ABC B 0.596 204 / 30,208 2,717 / 99,729 4309 0.675 2.724 0.248 0.059 + locoL_fullsat_s20000_K1000 HSPC 0.544 190 / 123,000 649 / 589,478 741 0.154 0.110 1.403 0.157 + locoL_fullsat_s20000_K1000 Cytotoxic CD4 T 0.782 412 / 18,475 1,928 / 140,213 2091 2.230 1.375 1.622 0.569 + locoL_fullsat_s20000_K1000 Granulocyte-like (LDG) 0.544 21 / 123,000 7,441 / 589,478 14337 0.017 1.262 0.014 0.003 + locoL_fullsat_s20000_K1000 Platelet signal in monocytes (negative control) 0.338 918 / 24,002 9,482 / 111,269 23329 3.825 8.522 0.449 0.218 + locoL_fullsat_s108500_K1000 C1Q-high monocyte (reference) 0.370 94 / 19,494 5,757 / 111,269 6788 0.482 5.174 0.093 0.018 + locoL_fullsat_s108500_K1000 Cycling T/NK 0.546 168 / 64,331 2,539 / 345,949 3461 0.261 0.734 0.356 -0.023 + locoL_fullsat_s108500_K1000 Cycling activated T (CD38/HLA-DR) 0.578 143 / 47,593 3,950 / 298,117 5877 0.300 1.325 0.227 0.038 + locoL_fullsat_s108500_K1000 Proliferating T (label) 1.000 862 / 47,593 4,793 / 298,117 4793 1.811 1.608 1.127 0.036 + locoL_fullsat_s108500_K1000 Plasmablast (label) 1.000 3,891 / 123,000 8,423 / 589,478 8423 3.163 1.429 2.214 0.228 + locoL_fullsat_s108500_K1000 Plasmablast (markers) 0.536 4,968 / 123,000 16,158 / 589,478 26774 4.039 2.741 1.474 0.347 + locoL_fullsat_s108500_K1000 MS1 monocyte (IL1R2+) 0.370 530 / 19,494 11,411 / 111,269 18712 2.719 10.255 0.265 0.505 + locoL_fullsat_s108500_K1000 Cycling monocyte (Ye 2026) 0.370 48 / 19,494 2,398 / 111,269 4601 0.246 2.155 0.114 0.318 + locoL_fullsat_s108500_K1000 ISG-high monocyte (positive control) 0.370 3,082 / 19,494 9,931 / 111,269 21377 15.810 8.925 1.771 0.458 + locoL_fullsat_s108500_K1000 ISG-high T 0.578 1,975 / 47,593 6,031 / 298,117 10685 4.150 2.023 2.051 0.472 + locoL_fullsat_s108500_K1000 DN2 / ABC B 0.567 248 / 33,880 2,573 / 99,729 4309 0.732 2.580 0.284 0.390 + locoL_fullsat_s108500_K1000 HSPC 0.536 401 / 123,000 648 / 589,478 741 0.326 0.110 2.966 0.070 + locoL_fullsat_s108500_K1000 Cytotoxic CD4 T 0.690 330 / 15,734 1,828 / 140,213 2091 2.097 1.304 1.609 0.616 + locoL_fullsat_s108500_K1000 Granulocyte-like (LDG) 0.536 24 / 123,000 7,235 / 589,478 14337 0.020 1.227 0.016 0.135 + locoL_fullsat_s108500_K1000 Platelet signal in monocytes (negative control) 0.370 652 / 19,494 10,416 / 111,269 23329 3.345 9.361 0.357 0.269 + locoL_scratchsat_s50000_K1000 C1Q-high monocyte (reference) 1.000 126 / 22,424 6,788 / 111,269 6788 0.562 6.101 0.092 0.206 + locoL_scratchsat_s50000_K1000 Cycling T/NK 1.000 45 / 74,248 3,461 / 345,949 3461 0.061 1.000 0.061 0.001 + locoL_scratchsat_s50000_K1000 Cycling activated T (CD38/HLA-DR) 1.000 86 / 55,016 5,877 / 298,117 5877 0.156 1.971 0.079 -0.049 + locoL_scratchsat_s50000_K1000 Proliferating T (label) 1.000 393 / 55,016 4,793 / 298,117 4793 0.714 1.608 0.444 -0.088 + locoL_scratchsat_s50000_K1000 Plasmablast (label) 1.000 855 / 123,000 8,423 / 589,478 8423 0.695 1.429 0.486 0.361 + locoL_scratchsat_s50000_K1000 Plasmablast (markers) 1.000 1,461 / 123,000 26,774 / 589,478 26774 1.188 4.542 0.262 0.429 + locoL_scratchsat_s50000_K1000 MS1 monocyte (IL1R2+) 1.000 595 / 22,424 18,712 / 111,269 18712 2.653 16.817 0.158 0.511 + locoL_scratchsat_s50000_K1000 Cycling monocyte (Ye 2026) 1.000 55 / 22,424 4,601 / 111,269 4601 0.245 4.135 0.059 0.274 + locoL_scratchsat_s50000_K1000 ISG-high monocyte (positive control) 1.000 2,268 / 22,424 21,377 / 111,269 21377 10.114 19.212 0.526 0.442 + locoL_scratchsat_s50000_K1000 ISG-high T 1.000 1,374 / 55,016 10,685 / 298,117 10685 2.497 3.584 0.697 0.248 + locoL_scratchsat_s50000_K1000 DN2 / ABC B 1.000 156 / 22,935 4,309 / 99,729 4309 0.680 4.321 0.157 0.077 + locoL_scratchsat_s50000_K1000 HSPC 1.000 148 / 123,000 741 / 589,478 741 0.120 0.126 0.957 0.189 + locoL_scratchsat_s50000_K1000 Cytotoxic CD4 T 1.000 270 / 21,052 2,091 / 140,213 2091 1.283 1.491 0.860 0.393 + locoL_scratchsat_s50000_K1000 Granulocyte-like (LDG) 1.000 106 / 123,000 14,337 / 589,478 14337 0.086 2.432 0.035 0.445 + locoL_scratchsat_s50000_K1000 Platelet signal in monocytes (negative control) 1.000 618 / 22,424 23,329 / 111,269 23329 2.756 20.966 0.131 0.307 +locoL_scratchsat_s100000_K1000 C1Q-high monocyte (reference) 1.000 114 / 22,868 6,788 / 111,269 6788 0.499 6.101 0.082 0.234 +locoL_scratchsat_s100000_K1000 Cycling T/NK 1.000 88 / 70,677 3,461 / 345,949 3461 0.125 1.000 0.124 0.013 +locoL_scratchsat_s100000_K1000 Cycling activated T (CD38/HLA-DR) 1.000 113 / 53,046 5,877 / 298,117 5877 0.213 1.971 0.108 0.054 +locoL_scratchsat_s100000_K1000 Proliferating T (label) 1.000 444 / 53,046 4,793 / 298,117 4793 0.837 1.608 0.521 0.076 +locoL_scratchsat_s100000_K1000 Plasmablast (label) 1.000 1,187 / 123,000 8,423 / 589,478 8423 0.965 1.429 0.675 0.292 +locoL_scratchsat_s100000_K1000 Plasmablast (markers) 1.000 1,714 / 123,000 26,774 / 589,478 26774 1.393 4.542 0.307 0.485 +locoL_scratchsat_s100000_K1000 MS1 monocyte (IL1R2+) 1.000 448 / 22,868 18,712 / 111,269 18712 1.959 16.817 0.116 0.510 +locoL_scratchsat_s100000_K1000 Cycling monocyte (Ye 2026) 1.000 21 / 22,868 4,601 / 111,269 4601 0.092 4.135 0.022 0.223 +locoL_scratchsat_s100000_K1000 ISG-high monocyte (positive control) 1.000 1,918 / 22,868 21,377 / 111,269 21377 8.387 19.212 0.437 0.405 +locoL_scratchsat_s100000_K1000 ISG-high T 1.000 1,078 / 53,046 10,685 / 298,117 10685 2.032 3.584 0.567 0.379 +locoL_scratchsat_s100000_K1000 DN2 / ABC B 1.000 176 / 24,584 4,309 / 99,729 4309 0.716 4.321 0.166 0.154 +locoL_scratchsat_s100000_K1000 HSPC 1.000 399 / 123,000 741 / 589,478 741 0.324 0.126 2.581 0.103 +locoL_scratchsat_s100000_K1000 Cytotoxic CD4 T 1.000 306 / 20,421 2,091 / 140,213 2091 1.498 1.491 1.005 0.426 +locoL_scratchsat_s100000_K1000 Granulocyte-like (LDG) 1.000 44 / 123,000 14,337 / 589,478 14337 0.036 2.432 0.015 0.437 +locoL_scratchsat_s100000_K1000 Platelet signal in monocytes (negative control) 1.000 537 / 22,868 23,329 / 111,269 23329 2.348 20.966 0.112 0.192 +locoL_scratchsat_s150000_K1000 C1Q-high monocyte (reference) 1.000 106 / 24,718 6,788 / 111,269 6788 0.429 6.101 0.070 0.276 +locoL_scratchsat_s150000_K1000 Cycling T/NK 1.000 46 / 67,979 3,461 / 345,949 3461 0.068 1.000 0.068 0.012 +locoL_scratchsat_s150000_K1000 Cycling activated T (CD38/HLA-DR) 1.000 74 / 51,762 5,877 / 298,117 5877 0.143 1.971 0.073 0.003 +locoL_scratchsat_s150000_K1000 Proliferating T (label) 1.000 469 / 51,762 4,793 / 298,117 4793 0.906 1.608 0.564 0.034 +locoL_scratchsat_s150000_K1000 Plasmablast (label) 1.000 1,395 / 123,000 8,423 / 589,478 8423 1.134 1.429 0.794 0.286 +locoL_scratchsat_s150000_K1000 Plasmablast (markers) 1.000 1,841 / 123,000 26,774 / 589,478 26774 1.497 4.542 0.330 0.492 +locoL_scratchsat_s150000_K1000 MS1 monocyte (IL1R2+) 1.000 437 / 24,718 18,712 / 111,269 18712 1.768 16.817 0.105 0.409 +locoL_scratchsat_s150000_K1000 Cycling monocyte (Ye 2026) 1.000 20 / 24,718 4,601 / 111,269 4601 0.081 4.135 0.020 0.062 +locoL_scratchsat_s150000_K1000 ISG-high monocyte (positive control) 1.000 2,373 / 24,718 21,377 / 111,269 21377 9.600 19.212 0.500 0.402 +locoL_scratchsat_s150000_K1000 ISG-high T 1.000 1,116 / 51,762 10,685 / 298,117 10685 2.156 3.584 0.602 0.343 +locoL_scratchsat_s150000_K1000 DN2 / ABC B 1.000 201 / 26,415 4,309 / 99,729 4309 0.761 4.321 0.176 0.059 +locoL_scratchsat_s150000_K1000 HSPC 1.000 201 / 123,000 741 / 589,478 741 0.163 0.126 1.300 0.293 +locoL_scratchsat_s150000_K1000 Cytotoxic CD4 T 1.000 271 / 19,128 2,091 / 140,213 2091 1.417 1.491 0.950 0.481 +locoL_scratchsat_s150000_K1000 Granulocyte-like (LDG) 1.000 33 / 123,000 14,337 / 589,478 14337 0.027 2.432 0.011 0.186 +locoL_scratchsat_s150000_K1000 Platelet signal in monocytes (negative control) 1.000 386 / 24,718 23,329 / 111,269 23329 1.562 20.966 0.074 0.228 +locoL_scratchsat_s162000_K1000 C1Q-high monocyte (reference) 1.000 86 / 20,808 6,788 / 111,269 6788 0.413 6.101 0.068 0.100 +locoL_scratchsat_s162000_K1000 Cycling T/NK 1.000 35 / 72,018 3,461 / 345,949 3461 0.049 1.000 0.049 -0.054 +locoL_scratchsat_s162000_K1000 Cycling activated T (CD38/HLA-DR) 1.000 56 / 55,309 5,877 / 298,117 5877 0.101 1.971 0.051 0.163 +locoL_scratchsat_s162000_K1000 Proliferating T (label) 1.000 473 / 55,309 4,793 / 298,117 4793 0.855 1.608 0.532 0.093 +locoL_scratchsat_s162000_K1000 Plasmablast (label) 1.000 1,537 / 123,000 8,423 / 589,478 8423 1.250 1.429 0.875 0.315 +locoL_scratchsat_s162000_K1000 Plasmablast (markers) 1.000 1,891 / 123,000 26,774 / 589,478 26774 1.537 4.542 0.338 0.507 +locoL_scratchsat_s162000_K1000 MS1 monocyte (IL1R2+) 1.000 357 / 20,808 18,712 / 111,269 18712 1.716 16.817 0.102 0.523 +locoL_scratchsat_s162000_K1000 Cycling monocyte (Ye 2026) 1.000 21 / 20,808 4,601 / 111,269 4601 0.101 4.135 0.024 0.072 +locoL_scratchsat_s162000_K1000 ISG-high monocyte (positive control) 1.000 1,889 / 20,808 21,377 / 111,269 21377 9.078 19.212 0.473 0.406 +locoL_scratchsat_s162000_K1000 ISG-high T 1.000 1,188 / 55,309 10,685 / 298,117 10685 2.148 3.584 0.599 0.383 +locoL_scratchsat_s162000_K1000 DN2 / ABC B 1.000 188 / 26,655 4,309 / 99,729 4309 0.705 4.321 0.163 0.105 +locoL_scratchsat_s162000_K1000 HSPC 1.000 203 / 123,000 741 / 589,478 741 0.165 0.126 1.313 0.275 +locoL_scratchsat_s162000_K1000 Cytotoxic CD4 T 1.000 289 / 20,606 2,091 / 140,213 2091 1.403 1.491 0.940 0.404 +locoL_scratchsat_s162000_K1000 Granulocyte-like (LDG) 1.000 35 / 123,000 14,337 / 589,478 14337 0.028 2.432 0.012 0.183 +locoL_scratchsat_s162000_K1000 Platelet signal in monocytes (negative control) 1.000 341 / 20,808 23,329 / 111,269 23329 1.639 20.966 0.078 0.159 + lora_n5__raw C1Q-high monocyte (reference) 0.821 669 / 21,211 6,612 / 111,269 6788 3.154 5.942 0.531 0.152 + lora_n5__raw Cycling T/NK 0.929 211 / 76,200 3,331 / 345,949 3461 0.277 0.963 0.288 0.122 + lora_n5__raw Cycling activated T (CD38/HLA-DR) 0.914 205 / 71,032 5,478 / 298,117 5877 0.289 1.838 0.157 0.116 + lora_n5__raw Proliferating T (label) 1.000 703 / 71,032 4,793 / 298,117 4793 0.990 1.608 0.616 0.222 + lora_n5__raw Plasmablast (label) 1.000 712 / 123,000 8,423 / 589,478 8423 0.579 1.429 0.405 0.125 + lora_n5__raw Plasmablast (markers) 0.908 998 / 123,000 24,720 / 589,478 26774 0.811 4.194 0.193 0.370 + lora_n5__raw MS1 monocyte (IL1R2+) 0.821 2,129 / 21,211 17,336 / 111,269 18712 10.037 15.580 0.644 0.439 + lora_n5__raw Cycling monocyte (Ye 2026) 0.821 235 / 21,211 4,056 / 111,269 4601 1.108 3.645 0.304 0.165 + lora_n5__raw ISG-high monocyte (positive control) 0.821 1,957 / 21,211 18,703 / 111,269 21377 9.226 16.809 0.549 0.309 + lora_n5__raw ISG-high T 0.914 898 / 71,032 9,763 / 298,117 10685 1.264 3.275 0.386 0.519 + lora_n5__raw DN2 / ABC B 0.915 363 / 21,371 3,994 / 99,729 4309 1.699 4.005 0.424 0.047 + lora_n5__raw HSPC 0.908 107 / 123,000 727 / 589,478 741 0.087 0.123 0.705 -0.001 + lora_n5__raw Cytotoxic CD4 T 0.949 518 / 33,233 2,058 / 140,213 2091 1.559 1.468 1.062 0.541 + lora_n5__raw Granulocyte-like (LDG) 0.908 106 / 123,000 12,961 / 589,478 14337 0.086 2.199 0.039 0.354 + lora_n5__raw Platelet signal in monocytes (negative control) 0.821 2,194 / 21,211 20,052 / 111,269 23329 10.344 18.021 0.574 0.203 + real_lora__raw C1Q-high monocyte (reference) 0.823 676 / 22,723 6,599 / 111,269 6788 2.975 5.931 0.502 0.217 + real_lora__raw Cycling T/NK 1.000 405 / 75,578 3,461 / 345,949 3461 0.536 1.000 0.536 0.332 + real_lora__raw Cycling activated T (CD38/HLA-DR) 0.996 396 / 67,850 5,860 / 298,117 5877 0.584 1.966 0.297 0.173 + real_lora__raw Proliferating T (label) 1.000 846 / 67,850 4,793 / 298,117 4793 1.247 1.608 0.776 0.386 + real_lora__raw Plasmablast (label) 1.000 1,331 / 123,000 8,423 / 589,478 8423 1.082 1.429 0.757 0.195 + real_lora__raw Plasmablast (markers) 0.957 1,803 / 123,000 25,808 / 589,478 26774 1.466 4.378 0.335 0.433 + real_lora__raw MS1 monocyte (IL1R2+) 0.823 2,507 / 22,723 17,362 / 111,269 18712 11.033 15.604 0.707 0.571 + real_lora__raw Cycling monocyte (Ye 2026) 0.823 189 / 22,723 4,056 / 111,269 4601 0.832 3.645 0.228 0.128 + real_lora__raw ISG-high monocyte (positive control) 0.823 2,332 / 22,723 18,665 / 111,269 21377 10.263 16.775 0.612 0.601 + real_lora__raw ISG-high T 0.996 1,378 / 67,850 10,634 / 298,117 10685 2.031 3.567 0.569 0.699 + real_lora__raw DN2 / ABC B 0.934 249 / 19,896 4,036 / 99,729 4309 1.252 4.047 0.309 0.423 + real_lora__raw HSPC 0.957 61 / 123,000 732 / 589,478 741 0.050 0.124 0.399 0.049 + real_lora__raw Cytotoxic CD4 T 1.000 609 / 30,246 2,091 / 140,213 2091 2.013 1.491 1.350 0.692 + real_lora__raw Granulocyte-like (LDG) 0.957 196 / 123,000 13,680 / 589,478 14337 0.159 2.321 0.069 0.378 + real_lora__raw Platelet signal in monocytes (negative control) 0.823 2,308 / 22,723 20,063 / 111,269 23329 10.157 18.031 0.563 0.100 + arm state contrast n_a n_b obs_a obs_b gen_a gen_b obs_diff gen_diff same_direction + zs__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3281 / 57131 105 / 8702 41 / 30375 1 / 2195 5.45 0.08 True + zs__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2114 / 15430 33 / 4363 10 / 6066 2 / 897 8.48 -0.02 False + zs__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5395 / 72561 513 / 38708 51 / 36441 12 / 9033 6.12 0.01 True + zs__raw Cycling T/NK adult sepsis vs adult HC 46 7 807 / 187719 108 / 44192 158 / 27878 18 / 7023 0.32 0.37 True + zs__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 545 / 43733 248 / 24170 80 / 10404 10 / 3500 0.16 0.52 True + zs__raw Cycling T/NK all sepsis vs all controls 61 21 1352 / 231452 880 / 114497 238 / 38282 56 / 16631 -0.12 0.30 False + zs__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 1249 / 162485 195 / 33194 107 / 20787 9 / 5978 0.41 0.47 True + zs__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 659 / 40153 371 / 20916 37 / 8615 3 / 3099 -0.27 0.40 False + zs__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 1908 / 202638 1290 / 95479 144 / 29402 24 / 13945 -0.32 0.38 False + zs__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 776 / 20787 74 / 5978 -0.06 2.65 False + zs__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 399 / 8615 36 / 3099 -0.18 3.77 False + zs__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 1175 / 29402 194 / 13945 -0.62 2.52 False + zs__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 342 / 69000 1 / 10500 0.97 0.49 True + zs__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 299 / 22500 1 / 6000 -0.14 1.31 False + zs__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 641 / 91500 37 / 31500 0.29 0.58 True + zs__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 6497 / 310451 442 / 59344 468 / 69000 11 / 10500 1.26 0.57 True + zs__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 4409 / 98395 2024 / 35572 342 / 22500 10 / 6000 -1.50 1.35 False + zs__raw Plasmablast (markers) all sepsis vs all controls 61 21 10906 / 408846 4369 / 180632 810 / 91500 72 / 31500 -0.06 0.66 False + zs__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 8049 / 57131 18 / 8702 331 / 30375 1 / 2195 12.73 0.85 True + zs__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 1894 / 15430 0 / 4363 54 / 6066 0 / 897 14.19 0.74 True + zs__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 9943 / 72561 2420 / 38708 385 / 36441 18 / 9033 7.86 0.72 True + zs__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1106 / 57131 52 / 8702 72 / 30375 6 / 2195 1.07 -0.03 False + zs__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1188 / 15430 31 / 4363 22 / 6066 1 / 897 5.31 0.28 True + zs__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 2294 / 72561 324 / 38708 94 / 36441 9 / 9033 2.04 0.14 True + zs__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 4859 / 57131 653 / 8702 5219 / 30375 140 / 2195 3.32 12.25 True + zs__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 3628 / 15430 927 / 4363 1919 / 6066 297 / 897 -7.30 -3.20 True + zs__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 8487 / 72561 2542 / 38708 7138 / 36441 968 / 9033 2.10 7.39 True + zs__raw ISG-high T adult sepsis vs adult HC 46 7 912 / 162485 146 / 33194 371 / 20787 16 / 5978 0.78 1.34 True + zs__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 971 / 40153 2166 / 20916 357 / 8615 332 / 3099 -12.31 -6.02 True + zs__raw ISG-high T all sepsis vs all controls 61 21 1883 / 202638 2631 / 95479 728 / 29402 416 / 13945 -1.74 -0.39 True + zs__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1148 / 47206 171 / 4301 365 / 7936 46 / 1124 -0.18 0.93 False + zs__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 802 / 33660 160 / 4954 158 / 5234 33 / 1505 -0.37 1.39 False + zs__raw DN2 / ABC B all sepsis vs all controls 61 21 1950 / 80866 642 / 18863 523 / 13170 187 / 5146 0.16 0.77 True + zs__raw HSPC adult sepsis vs adult HC 46 7 336 / 310451 57 / 59344 48 / 69000 1 / 10500 0.01 0.06 True + zs__raw HSPC paediatric sepsis vs paediatric HC 15 4 138 / 98395 21 / 35572 10 / 22500 3 / 6000 0.08 -0.01 False + zs__raw HSPC all sepsis vs all controls 61 21 474 / 408846 155 / 180632 58 / 91500 14 / 31500 0.03 0.02 True + zs__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1076 / 83070 346 / 13845 50 / 6908 12 / 1517 -1.16 0.16 False + zs__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 60 / 17697 27 / 8125 7 / 3518 4 / 1480 -0.06 0.15 False + zs__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1136 / 100767 631 / 39446 57 / 10426 28 / 5228 -1.06 0.15 False + zs__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 4088 / 310451 446 / 59344 220 / 69000 15 / 10500 0.85 0.18 True + zs__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 1010 / 98395 96 / 35572 33 / 22500 7 / 6000 0.82 0.03 True + zs__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 5098 / 408846 1403 / 180632 253 / 91500 68 / 31500 0.56 0.06 True + zs__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 6667 / 57131 622 / 8702 983 / 30375 30 / 2195 3.05 1.67 True + zs__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 1695 / 15430 170 / 4363 151 / 6066 7 / 897 2.95 1.15 True + zs__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 8362 / 72561 3156 / 38708 1134 / 36441 174 / 9033 2.15 1.00 True + xcalL_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3676 / 57131 138 / 8702 103 / 22454 2 / 980 6.05 0.21 True + xcalL_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2285 / 15430 35 / 4363 19 / 4362 1 / 356 9.23 0.14 True + xcalL_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5961 / 72561 617 / 38708 122 / 26816 21 / 5680 6.82 0.13 True + xcalL_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 1086 / 187719 125 / 44192 179 / 37390 7 / 9012 0.48 0.51 True + xcalL_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 718 / 43733 372 / 24170 57 / 11112 4 / 4017 -0.02 0.46 False + xcalL_K1000 Cycling T/NK all sepsis vs all controls 61 21 1804 / 231452 1244 / 114497 236 / 48502 44 / 20905 -0.25 0.27 False + xcalL_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 1946 / 162485 328 / 33194 145 / 29736 7 / 7893 0.44 0.48 True + xcalL_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 879 / 40153 589 / 20916 44 / 9739 6 / 3708 -0.91 0.27 False + xcalL_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 2825 / 202638 2026 / 95479 189 / 39475 41 / 18138 -0.71 0.21 False + xcalL_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 343 / 29736 22 / 7893 -0.06 0.97 False + xcalL_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 162 / 9739 21 / 3708 -0.18 0.97 False + xcalL_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 505 / 39475 90 / 18138 -0.62 0.74 False + xcalL_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 833 / 69000 2 / 10500 0.97 1.19 True + xcalL_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 471 / 22500 24 / 6000 -0.14 1.69 False + xcalL_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1304 / 91500 65 / 31500 0.29 1.22 True + xcalL_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 9923 / 310451 804 / 59344 1040 / 69000 11 / 10500 1.65 1.40 True + xcalL_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 6529 / 98395 2752 / 35572 591 / 22500 43 / 6000 -1.49 1.91 False + xcalL_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 16452 / 408846 6434 / 180632 1631 / 91500 122 / 31500 -0.02 1.40 False + xcalL_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11085 / 57131 42 / 8702 2717 / 22454 3 / 980 17.53 8.85 True + xcalL_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2535 / 15430 6 / 4363 522 / 4362 0 / 356 20.19 7.79 True + xcalL_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 13620 / 72561 3565 / 38708 3239 / 26816 393 / 5680 10.55 6.24 True + xcalL_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1843 / 57131 85 / 8702 227 / 22454 0 / 980 1.97 0.82 True + xcalL_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1605 / 15430 40 / 4363 56 / 4362 1 / 356 6.71 0.78 True + xcalL_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3448 / 72561 527 / 38708 283 / 26816 10 / 5680 2.94 0.67 True + xcalL_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8077 / 57131 1353 / 8702 5336 / 22454 94 / 980 1.35 16.36 True + xcalL_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5515 / 15430 1342 / 4363 1676 / 4362 128 / 356 -7.12 1.29 False + xcalL_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 13592 / 72561 4709 / 38708 7012 / 26816 574 / 5680 1.95 12.32 True + xcalL_K1000 ISG-high T adult sepsis vs adult HC 46 7 2256 / 162485 356 / 33194 1089 / 29736 25 / 7893 1.48 3.08 True + xcalL_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 1979 / 40153 2963 / 20916 655 / 9739 663 / 3708 -15.36 -12.59 True + xcalL_K1000 ISG-high T all sepsis vs all controls 61 21 4235 / 202638 4040 / 95479 1744 / 39475 806 / 18138 -1.79 -0.18 True + xcalL_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1782 / 47206 279 / 4301 133 / 6629 3 / 403 -0.64 0.42 False + xcalL_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1418 / 33660 288 / 4954 59 / 6518 3 / 1578 -1.17 1.12 False + xcalL_K1000 DN2 / ABC B all sepsis vs all controls 61 21 3200 / 80866 1060 / 18863 192 / 13147 34 / 4325 -0.09 0.75 False + xcalL_K1000 HSPC adult sepsis vs adult HC 46 7 377 / 310451 65 / 59344 164 / 69000 2 / 10500 0.01 0.22 True + xcalL_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 153 / 98395 25 / 35572 57 / 22500 1 / 6000 0.08 0.24 True + xcalL_K1000 HSPC all sepsis vs all controls 61 21 530 / 408846 177 / 180632 221 / 91500 27 / 31500 0.03 0.16 True + xcalL_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1219 / 83070 411 / 13845 267 / 7317 65 / 996 -1.43 -1.79 True + xcalL_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 70 / 17697 37 / 8125 55 / 3858 17 / 1288 -0.16 1.06 False + xcalL_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1289 / 100767 745 / 39446 322 / 11175 135 / 4391 -1.17 -0.06 True + xcalL_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 7041 / 310451 853 / 59344 113 / 69000 4 / 10500 1.23 0.13 True + xcalL_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 1915 / 98395 229 / 35572 27 / 22500 0 / 6000 1.44 0.12 True + xcalL_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 8956 / 408846 2886 / 180632 140 / 91500 16 / 31500 0.70 0.10 True + xcalL_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 10809 / 57131 1070 / 8702 817 / 22454 14 / 980 4.49 2.29 True + xcalL_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 2898 / 15430 395 / 4363 90 / 4362 4 / 356 2.94 0.73 True + xcalL_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 13707 / 72561 5991 / 38708 907 / 26816 167 / 5680 1.84 1.14 True + locoL_lora16sat_s26750_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3256 / 57131 111 / 8702 24 / 13963 5 / 1677 5.58 -0.24 False + locoL_lora16sat_s26750_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2081 / 15430 31 / 4363 5 / 2836 1 / 452 8.21 -0.05 False + locoL_lora16sat_s26750_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5337 / 72561 525 / 38708 29 / 16799 12 / 5725 6.18 -0.08 False + locoL_lora16sat_s26750_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 936 / 187719 123 / 44192 43 / 38684 8 / 7284 0.39 0.01 True + locoL_lora16sat_s26750_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 625 / 43733 297 / 24170 16 / 10100 0 / 2921 0.13 0.20 True + locoL_lora16sat_s26750_K1000 Cycling T/NK all sepsis vs all controls 61 21 1561 / 231452 1067 / 114497 59 / 48784 17 / 17583 -0.19 0.04 False + locoL_lora16sat_s26750_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 1611 / 162485 281 / 33194 40 / 30072 4 / 5269 0.37 0.08 True + locoL_lora16sat_s26750_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 778 / 40153 489 / 20916 15 / 8009 1 / 2425 -0.62 0.24 False + locoL_lora16sat_s26750_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 2389 / 202638 1680 / 95479 55 / 38081 14 / 13505 -0.53 0.06 False + locoL_lora16sat_s26750_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 416 / 30072 47 / 5269 -0.06 0.64 False + locoL_lora16sat_s26750_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 141 / 8009 10 / 2425 -0.18 1.04 False + locoL_lora16sat_s26750_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 557 / 38081 97 / 13505 -0.62 0.67 False + locoL_lora16sat_s26750_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 1296 / 69000 17 / 10500 0.97 1.72 True + locoL_lora16sat_s26750_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 979 / 22500 38 / 6000 -0.14 3.72 False + locoL_lora16sat_s26750_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 2275 / 91500 145 / 31500 0.29 2.03 True + locoL_lora16sat_s26750_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 7297 / 310451 490 / 59344 1502 / 69000 41 / 10500 1.39 1.79 True + locoL_lora16sat_s26750_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 4873 / 98395 2239 / 35572 1065 / 22500 67 / 6000 -1.67 3.62 False + locoL_lora16sat_s26750_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 12170 / 408846 4924 / 180632 2567 / 91500 232 / 31500 -0.12 2.07 False + locoL_lora16sat_s26750_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 7810 / 57131 13 / 8702 223 / 13963 1 / 1677 12.51 1.23 True + locoL_lora16sat_s26750_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 1827 / 15430 2 / 4363 55 / 2836 1 / 452 12.83 0.90 True + locoL_lora16sat_s26750_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 9637 / 72561 2324 / 38708 278 / 16799 14 / 5725 7.55 1.03 True + locoL_lora16sat_s26750_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1097 / 57131 48 / 8702 23 / 13963 0 / 1677 1.02 0.14 True + locoL_lora16sat_s26750_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1130 / 15430 28 / 4363 8 / 2836 0 / 452 4.62 0.38 True + locoL_lora16sat_s26750_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 2227 / 72561 304 / 38708 31 / 16799 1 / 5725 1.82 0.19 True + locoL_lora16sat_s26750_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 4678 / 57131 577 / 8702 1691 / 13963 78 / 1677 5.26 11.70 True + locoL_lora16sat_s26750_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 3544 / 15430 899 / 4363 832 / 2836 61 / 452 -7.31 4.04 False + locoL_lora16sat_s26750_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 8222 / 72561 2394 / 38708 2523 / 16799 295 / 5725 3.38 9.41 True + locoL_lora16sat_s26750_K1000 ISG-high T adult sepsis vs adult HC 46 7 1559 / 162485 256 / 33194 914 / 30072 19 / 5269 1.12 2.31 True + locoL_lora16sat_s26750_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 1491 / 40153 2605 / 20916 632 / 8009 213 / 2425 -14.07 -8.00 True + locoL_lora16sat_s26750_K1000 ISG-high T all sepsis vs all controls 61 21 3050 / 202638 3345 / 95479 1546 / 38081 293 / 13505 -1.79 0.27 False + locoL_lora16sat_s26750_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1238 / 47206 187 / 4301 99 / 12976 6 / 1127 -0.19 0.18 False + locoL_lora16sat_s26750_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 938 / 33660 182 / 4954 23 / 8929 2 / 2488 -0.42 0.23 False + locoL_lora16sat_s26750_K1000 DN2 / ABC B all sepsis vs all controls 61 21 2176 / 80866 705 / 18863 122 / 21905 22 / 6955 0.14 0.23 True + locoL_lora16sat_s26750_K1000 HSPC adult sepsis vs adult HC 46 7 352 / 310451 58 / 59344 129 / 69000 7 / 10500 0.01 0.12 True + locoL_lora16sat_s26750_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 147 / 98395 24 / 35572 63 / 22500 3 / 6000 0.08 0.23 True + locoL_lora16sat_s26750_K1000 HSPC all sepsis vs all controls 61 21 499 / 408846 162 / 180632 192 / 91500 31 / 31500 0.03 0.11 True + locoL_lora16sat_s26750_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1119 / 83070 370 / 13845 221 / 10765 37 / 1170 -1.22 0.88 False + locoL_lora16sat_s26750_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 56 / 17697 29 / 8125 27 / 2988 8 / 1053 -0.11 0.54 False + locoL_lora16sat_s26750_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1175 / 100767 658 / 39446 248 / 13753 92 / 4701 -1.07 0.87 False + locoL_lora16sat_s26750_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 4891 / 310451 541 / 59344 9 / 69000 4 / 10500 0.98 -0.03 False + locoL_lora16sat_s26750_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 1247 / 98395 139 / 35572 1 / 22500 0 / 6000 0.95 0.00 True + locoL_lora16sat_s26750_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 6138 / 408846 1813 / 180632 10 / 91500 7 / 31500 0.61 -0.01 False + locoL_lora16sat_s26750_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 6417 / 57131 589 / 8702 272 / 13963 18 / 1677 3.55 1.01 True + locoL_lora16sat_s26750_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 1600 / 15430 189 / 4363 58 / 2836 4 / 452 3.52 0.71 True + locoL_lora16sat_s26750_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 8017 / 72561 3020 / 38708 330 / 16799 81 / 5725 2.71 0.82 True + locoL_lora64sat_s59000_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3242 / 57131 107 / 8702 37 / 12065 4 / 1434 5.32 0.00 True + locoL_lora64sat_s59000_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2065 / 15430 27 / 4363 7 / 2999 1 / 461 8.18 -0.29 False + locoL_lora64sat_s59000_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5307 / 72561 489 / 38708 44 / 15064 15 / 4990 5.99 -0.07 False + locoL_lora64sat_s59000_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 867 / 187719 112 / 44192 46 / 38063 3 / 6710 0.36 0.09 True + locoL_lora64sat_s59000_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 607 / 43733 265 / 24170 18 / 8640 0 / 2223 0.22 0.25 True + locoL_lora64sat_s59000_K1000 Cycling T/NK all sepsis vs all controls 61 21 1474 / 231452 959 / 114497 64 / 46703 12 / 16183 -0.12 0.08 False + locoL_lora64sat_s59000_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 1461 / 162485 242 / 33194 49 / 28887 5 / 4522 0.39 0.07 True + locoL_lora64sat_s59000_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 730 / 40153 447 / 20916 24 / 6597 0 / 1586 -0.52 0.41 False + locoL_lora64sat_s59000_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 2191 / 202638 1549 / 95479 73 / 35484 10 / 11646 -0.48 0.14 False + locoL_lora64sat_s59000_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 450 / 28887 57 / 4522 -0.06 0.53 False + locoL_lora64sat_s59000_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 192 / 6597 23 / 1586 -0.18 0.87 False + locoL_lora64sat_s59000_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 642 / 35484 144 / 11646 -0.62 0.48 False + locoL_lora64sat_s59000_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 833 / 69000 12 / 10500 0.97 1.09 True + locoL_lora64sat_s59000_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 831 / 22500 19 / 6000 -0.14 3.38 False + locoL_lora64sat_s59000_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1664 / 91500 111 / 31500 0.29 1.47 True + locoL_lora64sat_s59000_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 6629 / 310451 446 / 59344 1096 / 69000 33 / 10500 1.26 1.27 True + locoL_lora64sat_s59000_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 4563 / 98395 2058 / 35572 930 / 22500 43 / 6000 -1.45 3.42 False + locoL_lora64sat_s59000_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 11192 / 408846 4494 / 180632 2026 / 91500 218 / 31500 -0.09 1.52 False + locoL_lora64sat_s59000_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 7579 / 57131 18 / 8702 163 / 12065 0 / 1434 11.87 0.99 True + locoL_lora64sat_s59000_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 1752 / 15430 2 / 4363 45 / 2999 0 / 461 13.73 0.69 True + locoL_lora64sat_s59000_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 9331 / 72561 2241 / 38708 208 / 15064 27 / 4990 7.47 0.62 True + locoL_lora64sat_s59000_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1073 / 57131 43 / 8702 20 / 12065 0 / 1434 1.11 0.20 True + locoL_lora64sat_s59000_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1117 / 15430 24 / 4363 8 / 2999 1 / 461 5.09 -0.01 False + locoL_lora64sat_s59000_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 2190 / 72561 265 / 38708 28 / 15064 3 / 4990 1.98 0.14 True + locoL_lora64sat_s59000_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 4428 / 57131 569 / 8702 1538 / 12065 40 / 1434 4.60 12.66 True + locoL_lora64sat_s59000_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 3420 / 15430 854 / 4363 827 / 2999 76 / 461 -5.31 4.80 False + locoL_lora64sat_s59000_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 7848 / 72561 2251 / 38708 2365 / 15064 275 / 4990 3.40 9.06 True + locoL_lora64sat_s59000_K1000 ISG-high T adult sepsis vs adult HC 46 7 1262 / 162485 208 / 33194 842 / 28887 9 / 4522 0.97 2.33 True + locoL_lora64sat_s59000_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 1280 / 40153 2446 / 20916 609 / 6597 172 / 1586 -13.51 -8.05 True + locoL_lora64sat_s59000_K1000 ISG-high T all sepsis vs all controls 61 21 2542 / 202638 3071 / 95479 1451 / 35484 259 / 11646 -1.81 0.06 False + locoL_lora64sat_s59000_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1111 / 47206 175 / 4301 90 / 15091 12 / 1586 -0.16 -0.14 True + locoL_lora64sat_s59000_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 771 / 33660 144 / 4954 23 / 10077 9 / 3124 -0.13 -0.05 True + locoL_lora64sat_s59000_K1000 DN2 / ABC B all sepsis vs all controls 61 21 1882 / 80866 590 / 18863 113 / 25168 39 / 8590 0.44 -0.01 False + locoL_lora64sat_s59000_K1000 HSPC adult sepsis vs adult HC 46 7 334 / 310451 60 / 59344 278 / 69000 9 / 10500 0.00 0.32 True + locoL_lora64sat_s59000_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 141 / 98395 22 / 35572 62 / 22500 5 / 6000 0.08 0.19 True + locoL_lora64sat_s59000_K1000 HSPC all sepsis vs all controls 61 21 475 / 408846 162 / 180632 340 / 91500 53 / 31500 0.03 0.20 True + locoL_lora64sat_s59000_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1069 / 83070 336 / 13845 266 / 11194 29 / 776 -1.06 0.53 False + locoL_lora64sat_s59000_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 52 / 17697 22 / 8125 25 / 2376 7 / 725 0.02 0.85 True + locoL_lora64sat_s59000_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1121 / 100767 600 / 39446 291 / 13570 81 / 4248 -0.97 1.03 False + locoL_lora64sat_s59000_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 4336 / 310451 447 / 59344 13 / 69000 2 / 10500 0.92 -0.00 False + locoL_lora64sat_s59000_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 1057 / 98395 120 / 35572 1 / 22500 2 / 6000 0.80 -0.03 False + locoL_lora64sat_s59000_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 5393 / 408846 1471 / 180632 14 / 91500 9 / 31500 0.61 -0.01 False + locoL_lora64sat_s59000_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 6114 / 57131 542 / 8702 218 / 12065 22 / 1434 3.25 0.47 True + locoL_lora64sat_s59000_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 1551 / 15430 166 / 4363 50 / 2999 6 / 461 2.56 0.02 True + locoL_lora64sat_s59000_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 7665 / 72561 2817 / 38708 268 / 15064 74 / 4990 2.32 0.22 True + locoL_fullsat_s20000_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3175 / 57131 95 / 8702 68 / 15193 10 / 1864 5.43 -0.13 False + locoL_fullsat_s20000_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2019 / 15430 24 / 4363 8 / 3084 1 / 349 7.59 -0.12 False + locoL_fullsat_s20000_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5194 / 72561 460 / 38708 76 / 18277 27 / 5725 5.88 -0.03 False + locoL_fullsat_s20000_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 947 / 187719 127 / 44192 110 / 37250 9 / 7194 0.38 0.19 True + locoL_fullsat_s20000_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 623 / 43733 309 / 24170 22 / 9116 6 / 2960 0.04 0.05 True + locoL_fullsat_s20000_K1000 Cycling T/NK all sepsis vs all controls 61 21 1570 / 231452 1069 / 114497 132 / 46366 38 / 17716 -0.18 0.08 False + locoL_fullsat_s20000_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 1661 / 162485 262 / 33194 93 / 28623 4 / 5466 0.47 0.28 True + locoL_fullsat_s20000_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 792 / 40153 495 / 20916 24 / 7112 3 / 2395 -0.63 0.29 False + locoL_fullsat_s20000_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 2453 / 202638 1682 / 95479 117 / 35735 25 / 13745 -0.51 0.19 False + locoL_fullsat_s20000_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 533 / 28623 53 / 5466 -0.06 1.18 False + locoL_fullsat_s20000_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 177 / 7112 24 / 2395 -0.18 1.40 False + locoL_fullsat_s20000_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 710 / 35735 152 / 13745 -0.62 0.91 False + locoL_fullsat_s20000_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 1861 / 69000 10 / 10500 0.97 2.60 True + locoL_fullsat_s20000_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 1160 / 22500 28 / 6000 -0.14 4.69 False + locoL_fullsat_s20000_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 3021 / 91500 96 / 31500 0.29 3.00 True + locoL_fullsat_s20000_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 6975 / 310451 480 / 59344 2193 / 69000 34 / 10500 1.32 2.85 True + locoL_fullsat_s20000_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 4711 / 98395 2100 / 35572 1324 / 22500 81 / 6000 -1.41 4.53 False + locoL_fullsat_s20000_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 11686 / 408846 4652 / 180632 3517 / 91500 239 / 31500 -0.07 3.08 False + locoL_fullsat_s20000_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 7069 / 57131 12 / 8702 542 / 15193 0 / 1864 10.35 2.51 True + locoL_fullsat_s20000_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 1675 / 15430 1 / 4363 108 / 3084 0 / 349 12.17 2.07 True + locoL_fullsat_s20000_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 8744 / 72561 2033 / 38708 650 / 18277 29 / 5725 6.33 2.12 True + locoL_fullsat_s20000_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 954 / 57131 44 / 8702 55 / 15193 1 / 1864 1.03 0.35 True + locoL_fullsat_s20000_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1019 / 15430 22 / 4363 14 / 3084 0 / 349 3.96 0.29 True + locoL_fullsat_s20000_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 1973 / 72561 280 / 38708 69 / 18277 4 / 5725 1.63 0.31 True + locoL_fullsat_s20000_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 4054 / 57131 480 / 8702 1853 / 15193 66 / 1864 4.09 13.04 True + locoL_fullsat_s20000_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 3140 / 15430 795 / 4363 621 / 3084 47 / 349 -6.50 -4.02 True + locoL_fullsat_s20000_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 7194 / 72561 2023 / 38708 2474 / 18277 253 / 5725 2.40 8.00 True + locoL_fullsat_s20000_K1000 ISG-high T adult sepsis vs adult HC 46 7 1596 / 162485 254 / 33194 700 / 28623 22 / 5466 1.11 1.84 True + locoL_fullsat_s20000_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 1545 / 40153 2649 / 20916 468 / 7112 222 / 2395 -14.28 -10.53 True + locoL_fullsat_s20000_K1000 ISG-high T all sepsis vs all controls 61 21 3141 / 202638 3405 / 95479 1168 / 35735 301 / 13745 -1.85 -0.54 True + locoL_fullsat_s20000_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1189 / 47206 188 / 4301 133 / 13570 6 / 998 -0.37 0.52 False + locoL_fullsat_s20000_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 867 / 33660 161 / 4954 50 / 9704 2 / 2595 -0.36 0.57 False + locoL_fullsat_s20000_K1000 DN2 / ABC B all sepsis vs all controls 61 21 2056 / 80866 661 / 18863 183 / 23274 21 / 6934 0.11 0.57 True + locoL_fullsat_s20000_K1000 HSPC adult sepsis vs adult HC 46 7 351 / 310451 51 / 59344 129 / 69000 4 / 10500 0.02 0.15 True + locoL_fullsat_s20000_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 141 / 98395 24 / 35572 34 / 22500 1 / 6000 0.07 0.13 True + locoL_fullsat_s20000_K1000 HSPC all sepsis vs all controls 61 21 492 / 408846 157 / 180632 163 / 91500 27 / 31500 0.03 0.09 True + locoL_fullsat_s20000_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1178 / 83070 379 / 13845 231 / 10807 76 / 1362 -1.22 -0.47 True + locoL_fullsat_s20000_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 68 / 17697 34 / 8125 30 / 2782 12 / 990 -0.10 1.00 False + locoL_fullsat_s20000_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1246 / 100767 682 / 39446 261 / 13589 151 / 4886 -1.04 0.47 False + locoL_fullsat_s20000_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 4583 / 310451 527 / 59344 15 / 69000 1 / 10500 0.88 0.01 True + locoL_fullsat_s20000_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 1183 / 98395 124 / 35572 1 / 22500 0 / 6000 0.93 0.00 True + locoL_fullsat_s20000_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 5766 / 408846 1675 / 180632 16 / 91500 5 / 31500 0.59 0.00 True + locoL_fullsat_s20000_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 5600 / 57131 521 / 8702 640 / 15193 41 / 1864 2.62 1.30 True + locoL_fullsat_s20000_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 1381 / 15430 149 / 4363 103 / 3084 6 / 349 2.78 0.77 True + locoL_fullsat_s20000_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 6981 / 72561 2501 / 38708 743 / 18277 175 / 5725 2.18 0.84 True + locoL_fullsat_s108500_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3223 / 57131 94 / 8702 55 / 11904 11 / 2028 5.34 -0.23 False + locoL_fullsat_s108500_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2051 / 15430 25 / 4363 15 / 2414 0 / 310 7.83 0.83 True + locoL_fullsat_s108500_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5274 / 72561 483 / 38708 70 / 14318 24 / 5176 5.84 0.13 True + locoL_fullsat_s108500_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 928 / 187719 121 / 44192 103 / 39389 14 / 6301 0.38 0.05 True + locoL_fullsat_s108500_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 606 / 43733 289 / 24170 27 / 8056 4 / 2680 0.12 0.38 True + locoL_fullsat_s108500_K1000 Cycling T/NK all sepsis vs all controls 61 21 1534 / 231452 1005 / 114497 130 / 47445 38 / 16886 -0.13 0.11 False + locoL_fullsat_s108500_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 1562 / 162485 257 / 33194 93 / 29481 14 / 4443 0.42 0.03 True + locoL_fullsat_s108500_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 751 / 40153 495 / 20916 21 / 5724 3 / 2031 -0.72 0.49 False + locoL_fullsat_s108500_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 2313 / 202638 1637 / 95479 114 / 35205 29 / 12388 -0.51 0.17 False + locoL_fullsat_s108500_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 551 / 29481 50 / 4443 -0.06 0.87 False + locoL_fullsat_s108500_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 170 / 5724 17 / 2031 -0.18 3.06 False + locoL_fullsat_s108500_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 721 / 35205 141 / 12388 -0.62 1.18 False + locoL_fullsat_s108500_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 2108 / 69000 20 / 10500 0.97 2.86 True + locoL_fullsat_s108500_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 1632 / 22500 45 / 6000 -0.14 6.50 False + locoL_fullsat_s108500_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 3740 / 91500 151 / 31500 0.29 3.61 True + locoL_fullsat_s108500_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 6908 / 310451 437 / 59344 2632 / 69000 70 / 10500 1.37 3.15 True + locoL_fullsat_s108500_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 4664 / 98395 2087 / 35572 1917 / 22500 144 / 6000 -1.44 6.12 False + locoL_fullsat_s108500_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 11572 / 408846 4586 / 180632 4549 / 91500 419 / 31500 -0.06 3.64 False + locoL_fullsat_s108500_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 7405 / 57131 12 / 8702 401 / 11904 1 / 2028 11.89 3.03 True + locoL_fullsat_s108500_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 1776 / 15430 1 / 4363 106 / 2414 0 / 310 13.87 1.66 True + locoL_fullsat_s108500_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 9181 / 72561 2230 / 38708 507 / 14318 23 / 5176 7.49 2.47 True + locoL_fullsat_s108500_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1026 / 57131 49 / 8702 34 / 11904 1 / 2028 1.13 0.32 True + locoL_fullsat_s108500_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1096 / 15430 27 / 4363 12 / 2414 0 / 310 4.62 0.25 True + locoL_fullsat_s108500_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 2122 / 72561 276 / 38708 46 / 14318 2 / 5176 1.91 0.31 True + locoL_fullsat_s108500_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 4308 / 57131 536 / 8702 2077 / 11904 197 / 2028 4.74 15.55 True + locoL_fullsat_s108500_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 3428 / 15430 857 / 4363 539 / 2414 38 / 310 -6.44 -8.45 True + locoL_fullsat_s108500_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 7736 / 72561 2195 / 38708 2616 / 14318 466 / 5176 3.20 8.24 True + locoL_fullsat_s108500_K1000 ISG-high T adult sepsis vs adult HC 46 7 1380 / 162485 242 / 33194 817 / 29481 13 / 4443 0.92 2.16 True + locoL_fullsat_s108500_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 1384 / 40153 2557 / 20916 756 / 5724 265 / 2031 -14.02 -8.75 True + locoL_fullsat_s108500_K1000 ISG-high T all sepsis vs all controls 61 21 2764 / 202638 3267 / 95479 1573 / 35205 402 / 12388 -1.90 -0.26 True + locoL_fullsat_s108500_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1148 / 47206 175 / 4301 141 / 14849 18 / 1194 -0.10 -0.37 True + locoL_fullsat_s108500_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 810 / 33660 145 / 4954 58 / 11367 12 / 2858 -0.11 0.12 False + locoL_fullsat_s108500_K1000 DN2 / ABC B all sepsis vs all controls 61 21 1958 / 80866 615 / 18863 199 / 26216 49 / 7664 0.41 0.12 True + locoL_fullsat_s108500_K1000 HSPC adult sepsis vs adult HC 46 7 348 / 310451 53 / 59344 269 / 69000 12 / 10500 0.02 0.28 True + locoL_fullsat_s108500_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 143 / 98395 23 / 35572 67 / 22500 7 / 6000 0.08 0.18 True + locoL_fullsat_s108500_K1000 HSPC all sepsis vs all controls 61 21 491 / 408846 157 / 180632 336 / 91500 65 / 31500 0.03 0.16 True + locoL_fullsat_s108500_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1126 / 83070 350 / 13845 229 / 9642 37 / 981 -1.09 2.10 False + locoL_fullsat_s108500_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 61 / 17697 31 / 8125 18 / 2154 6 / 751 -0.10 0.51 False + locoL_fullsat_s108500_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1187 / 100767 641 / 39446 247 / 11796 83 / 3938 -0.93 1.88 False + locoL_fullsat_s108500_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 4498 / 310451 493 / 59344 16 / 69000 2 / 10500 0.90 0.00 True + locoL_fullsat_s108500_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 1133 / 98395 130 / 35572 2 / 22500 0 / 6000 0.86 0.01 True + locoL_fullsat_s108500_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 5631 / 408846 1604 / 180632 18 / 91500 6 / 31500 0.59 0.00 True + locoL_fullsat_s108500_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 6103 / 57131 546 / 8702 452 / 11904 48 / 2028 3.13 1.36 True + locoL_fullsat_s108500_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 1518 / 15430 159 / 4363 62 / 2414 4 / 310 2.85 0.16 True + locoL_fullsat_s108500_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 7621 / 72561 2795 / 38708 514 / 14318 138 / 5176 2.27 0.73 True + locoL_scratchsat_s50000_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3794 / 57131 144 / 8702 82 / 13649 17 / 1447 6.14 -0.37 False + locoL_scratchsat_s50000_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2339 / 15430 40 / 4363 19 / 3547 0 / 426 9.37 0.37 True + locoL_scratchsat_s50000_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 6133 / 72561 655 / 38708 101 / 17196 25 / 5228 6.91 0.15 True + locoL_scratchsat_s50000_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 26 / 42758 1 / 8098 0.51 0.05 True + locoL_scratchsat_s50000_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 15 / 11911 0 / 3438 -0.24 0.11 False + locoL_scratchsat_s50000_K1000 Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 41 / 54669 4 / 19579 -0.37 0.05 False + locoL_scratchsat_s50000_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2401 / 162485 422 / 33194 51 / 32341 5 / 5474 0.46 0.07 True + locoL_scratchsat_s50000_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 751 / 20916 19 / 8795 0 / 2354 -1.42 0.22 False + locoL_scratchsat_s50000_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3412 / 202638 2465 / 95479 70 / 41136 16 / 13880 -0.90 0.05 False + locoL_scratchsat_s50000_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 222 / 32341 38 / 5474 -0.06 0.02 False + locoL_scratchsat_s50000_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 85 / 8795 11 / 2354 -0.18 0.58 False + locoL_scratchsat_s50000_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 307 / 41136 86 / 13880 -0.62 0.12 False + locoL_scratchsat_s50000_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 407 / 69000 16 / 10500 0.97 0.44 True + locoL_scratchsat_s50000_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 369 / 22500 9 / 6000 -0.14 1.49 False + locoL_scratchsat_s50000_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 776 / 91500 79 / 31500 0.29 0.60 True + locoL_scratchsat_s50000_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 11716 / 310451 991 / 59344 686 / 69000 53 / 10500 1.88 0.49 True + locoL_scratchsat_s50000_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7674 / 98395 3047 / 35572 523 / 22500 59 / 6000 -1.18 1.34 False + locoL_scratchsat_s50000_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 19390 / 408846 7384 / 180632 1209 / 91500 252 / 31500 0.10 0.52 True + locoL_scratchsat_s50000_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 12017 / 57131 56 / 8702 408 / 13649 0 / 1447 18.97 2.17 True + locoL_scratchsat_s50000_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2757 / 15430 7 / 4363 57 / 3547 0 / 426 22.03 0.98 True + locoL_scratchsat_s50000_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 14774 / 72561 3938 / 38708 465 / 17196 130 / 5228 11.40 0.88 True + locoL_scratchsat_s50000_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 2156 / 57131 107 / 8702 34 / 13649 1 / 1447 2.15 0.24 True + locoL_scratchsat_s50000_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1801 / 15430 53 / 4363 16 / 3547 0 / 426 7.86 0.42 True + locoL_scratchsat_s50000_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3957 / 72561 644 / 38708 50 / 17196 5 / 5228 3.34 0.24 True + locoL_scratchsat_s50000_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 9490 / 57131 1676 / 8702 1480 / 13649 49 / 1447 -0.19 10.68 False + locoL_scratchsat_s50000_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 6227 / 15430 1520 / 4363 547 / 3547 86 / 426 -5.95 -3.49 True + locoL_scratchsat_s50000_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 15717 / 72561 5660 / 38708 2027 / 17196 241 / 5228 1.77 5.48 True + locoL_scratchsat_s50000_K1000 ISG-high T adult sepsis vs adult HC 46 7 3234 / 162485 542 / 33194 518 / 32341 0 / 5474 1.70 1.32 True + locoL_scratchsat_s50000_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 2623 / 40153 3251 / 20916 677 / 8795 157 / 2354 -15.64 -2.85 True + locoL_scratchsat_s50000_K1000 ISG-high T all sepsis vs all controls 61 21 5857 / 202638 4828 / 95479 1195 / 41136 179 / 13880 -1.65 0.58 False + locoL_scratchsat_s50000_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1804 / 47206 286 / 4301 87 / 10618 7 / 722 -0.84 0.10 False + locoL_scratchsat_s50000_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1435 / 33660 291 / 4954 30 / 6418 9 / 1997 -1.18 -0.04 True + locoL_scratchsat_s50000_K1000 DN2 / ABC B all sepsis vs all controls 61 21 3239 / 80866 1070 / 18863 117 / 17036 39 / 5899 -0.13 0.15 False + locoL_scratchsat_s50000_K1000 HSPC adult sepsis vs adult HC 46 7 391 / 310451 69 / 59344 77 / 69000 3 / 10500 0.01 0.08 True + locoL_scratchsat_s50000_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 159 / 98395 29 / 35572 37 / 22500 3 / 6000 0.08 0.11 True + locoL_scratchsat_s50000_K1000 HSPC all sepsis vs all controls 61 21 550 / 408846 191 / 180632 114 / 91500 34 / 31500 0.03 0.02 True + locoL_scratchsat_s50000_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 180 / 12432 25 / 1724 -1.46 2.14 False + locoL_scratchsat_s50000_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 26 / 3436 7 / 1014 -0.25 1.12 False + locoL_scratchsat_s50000_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 206 / 15868 64 / 5184 -1.22 1.68 False + locoL_scratchsat_s50000_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 8326 / 310451 1095 / 59344 76 / 69000 5 / 10500 1.27 0.06 True + locoL_scratchsat_s50000_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2362 / 98395 299 / 35572 15 / 22500 0 / 6000 1.72 0.07 True + locoL_scratchsat_s50000_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 10688 / 408846 3649 / 180632 91 / 91500 15 / 31500 0.70 0.05 True + locoL_scratchsat_s50000_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 12569 / 57131 1290 / 8702 448 / 13649 18 / 1447 4.69 1.24 True + locoL_scratchsat_s50000_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 3420 / 15430 505 / 4363 78 / 3547 6 / 426 4.08 0.52 True + locoL_scratchsat_s50000_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 15989 / 72561 7340 / 38708 526 / 17196 92 / 5228 1.65 0.87 True +locoL_scratchsat_s100000_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3794 / 57131 144 / 8702 85 / 13944 4 / 1372 6.14 0.15 True +locoL_scratchsat_s100000_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2339 / 15430 40 / 4363 15 / 3617 2 / 509 9.37 -0.19 False +locoL_scratchsat_s100000_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 6133 / 72561 655 / 38708 100 / 17561 14 / 5307 6.91 0.16 True +locoL_scratchsat_s100000_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 50 / 40939 1 / 7701 0.51 0.12 True +locoL_scratchsat_s100000_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 31 / 11222 2 / 3129 -0.24 0.21 False +locoL_scratchsat_s100000_K1000 Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 81 / 52161 7 / 18516 -0.37 0.13 False +locoL_scratchsat_s100000_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2401 / 162485 422 / 33194 63 / 31365 5 / 5366 0.46 0.13 True +locoL_scratchsat_s100000_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 751 / 20916 35 / 8541 3 / 2034 -1.42 0.30 False +locoL_scratchsat_s100000_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3412 / 202638 2465 / 95479 98 / 39906 15 / 13140 -0.90 0.15 False +locoL_scratchsat_s100000_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 249 / 31365 30 / 5366 -0.06 0.28 False +locoL_scratchsat_s100000_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 107 / 8541 16 / 2034 -0.18 0.58 False +locoL_scratchsat_s100000_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 356 / 39906 88 / 13140 -0.62 0.19 False +locoL_scratchsat_s100000_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 553 / 69000 29 / 10500 0.97 0.53 True +locoL_scratchsat_s100000_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 508 / 22500 22 / 6000 -0.14 1.89 False +locoL_scratchsat_s100000_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1061 / 91500 126 / 31500 0.29 0.76 True +locoL_scratchsat_s100000_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 11716 / 310451 991 / 59344 791 / 69000 60 / 10500 1.88 0.57 True +locoL_scratchsat_s100000_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7674 / 98395 3047 / 35572 651 / 22500 66 / 6000 -1.18 1.79 False +locoL_scratchsat_s100000_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 19390 / 408846 7384 / 180632 1442 / 91500 272 / 31500 0.10 0.71 True +locoL_scratchsat_s100000_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 12017 / 57131 56 / 8702 291 / 13944 2 / 1372 18.97 1.40 True +locoL_scratchsat_s100000_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2757 / 15430 7 / 4363 35 / 3617 0 / 509 22.03 0.78 True +locoL_scratchsat_s100000_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 14774 / 72561 3938 / 38708 326 / 17561 122 / 5307 11.40 0.41 True +locoL_scratchsat_s100000_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 2156 / 57131 107 / 8702 18 / 13944 0 / 1372 2.15 0.13 True +locoL_scratchsat_s100000_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1801 / 15430 53 / 4363 2 / 3617 0 / 509 7.86 0.03 True +locoL_scratchsat_s100000_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3957 / 72561 644 / 38708 20 / 17561 1 / 5307 3.34 0.10 True +locoL_scratchsat_s100000_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 9490 / 57131 1676 / 8702 1211 / 13944 51 / 1372 -0.19 8.94 False +locoL_scratchsat_s100000_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 6227 / 15430 1520 / 4363 463 / 3617 103 / 509 -5.95 -5.32 True +locoL_scratchsat_s100000_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 15717 / 72561 5660 / 38708 1674 / 17561 244 / 5307 1.77 5.53 True +locoL_scratchsat_s100000_K1000 ISG-high T adult sepsis vs adult HC 46 7 3234 / 162485 542 / 33194 372 / 31365 4 / 5366 1.70 0.95 True +locoL_scratchsat_s100000_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 2623 / 40153 3251 / 20916 565 / 8541 112 / 2034 -15.64 -2.03 True +locoL_scratchsat_s100000_K1000 ISG-high T all sepsis vs all controls 61 21 5857 / 202638 4828 / 95479 937 / 39906 141 / 13140 -1.65 0.47 False +locoL_scratchsat_s100000_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1804 / 47206 286 / 4301 94 / 11414 8 / 1091 -0.84 -0.23 True +locoL_scratchsat_s100000_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1435 / 33660 291 / 4954 40 / 6688 8 / 2148 -1.18 0.26 False +locoL_scratchsat_s100000_K1000 DN2 / ABC B all sepsis vs all controls 61 21 3239 / 80866 1070 / 18863 134 / 18102 42 / 6482 -0.13 -0.11 True +locoL_scratchsat_s100000_K1000 HSPC adult sepsis vs adult HC 46 7 391 / 310451 69 / 59344 206 / 69000 9 / 10500 0.01 0.21 True +locoL_scratchsat_s100000_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 159 / 98395 29 / 35572 114 / 22500 24 / 6000 0.08 0.11 True +locoL_scratchsat_s100000_K1000 HSPC all sepsis vs all controls 61 21 550 / 408846 191 / 180632 320 / 91500 79 / 31500 0.03 0.10 True +locoL_scratchsat_s100000_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 200 / 11993 30 / 1783 -1.46 1.21 False +locoL_scratchsat_s100000_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 33 / 3420 7 / 891 -0.25 0.72 False +locoL_scratchsat_s100000_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 233 / 15413 73 / 5008 -1.22 0.76 False +locoL_scratchsat_s100000_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 8326 / 310451 1095 / 59344 32 / 69000 2 / 10500 1.27 0.03 True +locoL_scratchsat_s100000_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2362 / 98395 299 / 35572 4 / 22500 0 / 6000 1.72 0.02 True +locoL_scratchsat_s100000_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 10688 / 408846 3649 / 180632 36 / 91500 8 / 31500 0.70 0.01 True +locoL_scratchsat_s100000_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 12569 / 57131 1290 / 8702 381 / 13944 14 / 1372 4.69 1.58 True +locoL_scratchsat_s100000_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 3420 / 15430 505 / 4363 70 / 3617 8 / 509 4.08 0.17 True +locoL_scratchsat_s100000_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 15989 / 72561 7340 / 38708 451 / 17561 86 / 5307 1.65 1.05 True +locoL_scratchsat_s150000_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3794 / 57131 144 / 8702 74 / 15214 4 / 1291 6.14 0.02 True +locoL_scratchsat_s150000_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2339 / 15430 40 / 4363 19 / 4043 0 / 590 9.37 0.33 True +locoL_scratchsat_s150000_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 6133 / 72561 655 / 38708 93 / 19257 13 / 5461 6.91 0.20 True +locoL_scratchsat_s150000_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 27 / 39656 0 / 7823 0.51 0.07 True +locoL_scratchsat_s150000_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 16 / 10564 0 / 2721 -0.24 0.14 False +locoL_scratchsat_s150000_K1000 Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 43 / 50220 3 / 17759 -0.37 0.07 False +locoL_scratchsat_s150000_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2401 / 162485 422 / 33194 47 / 30828 3 / 5645 0.46 0.11 True +locoL_scratchsat_s150000_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 751 / 20916 19 / 8050 1 / 1722 -1.42 0.15 False +locoL_scratchsat_s150000_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3412 / 202638 2465 / 95479 66 / 38878 8 / 12884 -0.90 0.11 False +locoL_scratchsat_s150000_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 263 / 30828 34 / 5645 -0.06 0.32 False +locoL_scratchsat_s150000_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 118 / 8050 12 / 1722 -0.18 0.66 False +locoL_scratchsat_s150000_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 381 / 38878 88 / 12884 -0.62 0.24 False +locoL_scratchsat_s150000_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 653 / 69000 27 / 10500 0.97 0.69 True +locoL_scratchsat_s150000_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 550 / 22500 44 / 6000 -0.14 1.71 False +locoL_scratchsat_s150000_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1203 / 91500 192 / 31500 0.29 0.71 True +locoL_scratchsat_s150000_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 11716 / 310451 991 / 59344 857 / 69000 48 / 10500 1.88 0.78 True +locoL_scratchsat_s150000_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7674 / 98395 3047 / 35572 682 / 22500 82 / 6000 -1.18 1.66 False +locoL_scratchsat_s150000_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 19390 / 408846 7384 / 180632 1539 / 91500 302 / 31500 0.10 0.72 True +locoL_scratchsat_s150000_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 12017 / 57131 56 / 8702 299 / 15214 0 / 1291 18.97 1.50 True +locoL_scratchsat_s150000_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2757 / 15430 7 / 4363 42 / 4043 0 / 590 22.03 0.72 True +locoL_scratchsat_s150000_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 14774 / 72561 3938 / 38708 341 / 19257 96 / 5461 11.40 0.66 True +locoL_scratchsat_s150000_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 2156 / 57131 107 / 8702 15 / 15214 0 / 1291 2.15 0.08 True +locoL_scratchsat_s150000_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1801 / 15430 53 / 4363 4 / 4043 0 / 590 7.86 0.05 True +locoL_scratchsat_s150000_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3957 / 72561 644 / 38708 19 / 19257 1 / 5461 3.34 0.06 True +locoL_scratchsat_s150000_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 9490 / 57131 1676 / 8702 1529 / 15214 47 / 1291 -0.19 10.09 False +locoL_scratchsat_s150000_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 6227 / 15430 1520 / 4363 542 / 4043 133 / 590 -5.95 -7.15 True +locoL_scratchsat_s150000_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 15717 / 72561 5660 / 38708 2071 / 19257 302 / 5461 1.77 5.75 True +locoL_scratchsat_s150000_K1000 ISG-high T adult sepsis vs adult HC 46 7 3234 / 162485 542 / 33194 420 / 30828 1 / 5645 1.70 1.15 True +locoL_scratchsat_s150000_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 2623 / 40153 3251 / 20916 577 / 8050 101 / 1722 -15.64 -3.12 True +locoL_scratchsat_s150000_K1000 ISG-high T all sepsis vs all controls 61 21 5857 / 202638 4828 / 95479 997 / 38878 119 / 12884 -1.65 0.42 False +locoL_scratchsat_s150000_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1804 / 47206 286 / 4301 122 / 11943 17 / 1123 -0.84 -0.60 True +locoL_scratchsat_s150000_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1435 / 33660 291 / 4954 33 / 7122 8 / 2510 -1.18 0.25 False +locoL_scratchsat_s150000_K1000 DN2 / ABC B all sepsis vs all controls 61 21 3239 / 80866 1070 / 18863 155 / 19065 46 / 7350 -0.13 0.08 False +locoL_scratchsat_s150000_K1000 HSPC adult sepsis vs adult HC 46 7 391 / 310451 69 / 59344 112 / 69000 4 / 10500 0.01 0.12 True +locoL_scratchsat_s150000_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 159 / 98395 29 / 35572 55 / 22500 4 / 6000 0.08 0.18 True +locoL_scratchsat_s150000_K1000 HSPC all sepsis vs all controls 61 21 550 / 408846 191 / 180632 167 / 91500 34 / 31500 0.03 0.07 True +locoL_scratchsat_s150000_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 184 / 11371 23 / 1758 -1.46 2.07 False +locoL_scratchsat_s150000_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 25 / 3154 6 / 705 -0.25 0.61 False +locoL_scratchsat_s150000_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 209 / 14525 62 / 4603 -1.22 1.16 False +locoL_scratchsat_s150000_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 8326 / 310451 1095 / 59344 22 / 69000 1 / 10500 1.27 0.02 True +locoL_scratchsat_s150000_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2362 / 98395 299 / 35572 4 / 22500 0 / 6000 1.72 0.02 True +locoL_scratchsat_s150000_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 10688 / 408846 3649 / 180632 26 / 91500 7 / 31500 0.70 0.01 True +locoL_scratchsat_s150000_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 12569 / 57131 1290 / 8702 290 / 15214 14 / 1291 4.69 0.67 True +locoL_scratchsat_s150000_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 3420 / 15430 505 / 4363 52 / 4043 1 / 590 4.08 0.72 True +locoL_scratchsat_s150000_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 15989 / 72561 7340 / 38708 342 / 19257 44 / 5461 1.65 0.90 True +locoL_scratchsat_s162000_K1000 C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3794 / 57131 144 / 8702 61 / 12841 2 / 1206 6.14 0.25 True +locoL_scratchsat_s162000_K1000 C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2339 / 15430 40 / 4363 12 / 3173 1 / 457 9.37 -0.13 False +locoL_scratchsat_s162000_K1000 C1Q-high monocyte (reference) all sepsis vs all controls 61 21 6133 / 72561 655 / 38708 73 / 16014 13 / 4794 6.91 0.08 True +locoL_scratchsat_s162000_K1000 Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 22 / 42154 0 / 7912 0.51 0.05 True +locoL_scratchsat_s162000_K1000 Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 12 / 11321 0 / 2939 -0.24 0.09 False +locoL_scratchsat_s162000_K1000 Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 34 / 53475 1 / 18543 -0.37 0.06 False +locoL_scratchsat_s162000_K1000 Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2401 / 162485 422 / 33194 31 / 32954 3 / 5726 0.46 0.04 True +locoL_scratchsat_s162000_K1000 Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 751 / 20916 17 / 8717 2 / 2003 -1.42 0.06 False +locoL_scratchsat_s162000_K1000 Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3412 / 202638 2465 / 95479 48 / 41671 8 / 13638 -0.90 0.04 False +locoL_scratchsat_s162000_K1000 Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 268 / 32954 37 / 5726 -0.06 0.24 False +locoL_scratchsat_s162000_K1000 Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 110 / 8717 21 / 2003 -0.18 0.16 False +locoL_scratchsat_s162000_K1000 Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 378 / 41671 95 / 13638 -0.62 0.18 False +locoL_scratchsat_s162000_K1000 Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 700 / 69000 32 / 10500 0.97 0.71 True +locoL_scratchsat_s162000_K1000 Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 631 / 22500 52 / 6000 -0.14 1.94 False +locoL_scratchsat_s162000_K1000 Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1331 / 91500 206 / 31500 0.29 0.80 True +locoL_scratchsat_s162000_K1000 Plasmablast (markers) adult sepsis vs adult HC 46 7 11716 / 310451 991 / 59344 863 / 69000 50 / 10500 1.88 0.77 True +locoL_scratchsat_s162000_K1000 Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7674 / 98395 3047 / 35572 730 / 22500 77 / 6000 -1.18 1.96 False +locoL_scratchsat_s162000_K1000 Plasmablast (markers) all sepsis vs all controls 61 21 19390 / 408846 7384 / 180632 1593 / 91500 298 / 31500 0.10 0.79 True +locoL_scratchsat_s162000_K1000 MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 12017 / 57131 56 / 8702 218 / 12841 0 / 1206 18.97 1.18 True +locoL_scratchsat_s162000_K1000 MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2757 / 15430 7 / 4363 35 / 3173 0 / 457 22.03 0.92 True +locoL_scratchsat_s162000_K1000 MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 14774 / 72561 3938 / 38708 253 / 16014 104 / 4794 11.40 0.39 True +locoL_scratchsat_s162000_K1000 Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 2156 / 57131 107 / 8702 12 / 12841 1 / 1206 2.15 0.12 True +locoL_scratchsat_s162000_K1000 Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1801 / 15430 53 / 4363 5 / 3173 0 / 457 7.86 0.13 True +locoL_scratchsat_s162000_K1000 Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3957 / 72561 644 / 38708 17 / 16014 4 / 4794 3.34 0.11 True +locoL_scratchsat_s162000_K1000 ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 9490 / 57131 1676 / 8702 1247 / 12841 35 / 1206 -0.19 10.47 False +locoL_scratchsat_s162000_K1000 ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 6227 / 15430 1520 / 4363 421 / 3173 89 / 457 -5.95 -2.93 True +locoL_scratchsat_s162000_K1000 ISG-high monocyte (positive control) all sepsis vs all controls 61 21 15717 / 72561 5660 / 38708 1668 / 16014 221 / 4794 1.77 6.51 True +locoL_scratchsat_s162000_K1000 ISG-high T adult sepsis vs adult HC 46 7 3234 / 162485 542 / 33194 481 / 32954 6 / 5726 1.70 1.14 True +locoL_scratchsat_s162000_K1000 ISG-high T paediatric sepsis vs paediatric HC 15 4 2623 / 40153 3251 / 20916 555 / 8717 121 / 2003 -15.64 -3.10 True +locoL_scratchsat_s162000_K1000 ISG-high T all sepsis vs all controls 61 21 5857 / 202638 4828 / 95479 1036 / 41671 152 / 13638 -1.65 0.40 False +locoL_scratchsat_s162000_K1000 DN2 / ABC B adult sepsis vs adult HC 46 7 1804 / 47206 286 / 4301 106 / 11999 13 / 1132 -0.84 -0.33 True +locoL_scratchsat_s162000_K1000 DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1435 / 33660 291 / 4954 35 / 7323 9 / 2456 -1.18 0.13 False +locoL_scratchsat_s162000_K1000 DN2 / ABC B all sepsis vs all controls 61 21 3239 / 80866 1070 / 18863 141 / 19322 47 / 7333 -0.13 0.00 False +locoL_scratchsat_s162000_K1000 HSPC adult sepsis vs adult HC 46 7 391 / 310451 69 / 59344 123 / 69000 6 / 10500 0.01 0.12 True +locoL_scratchsat_s162000_K1000 HSPC paediatric sepsis vs paediatric HC 15 4 159 / 98395 29 / 35572 41 / 22500 6 / 6000 0.08 0.08 True +locoL_scratchsat_s162000_K1000 HSPC all sepsis vs all controls 61 21 550 / 408846 191 / 180632 164 / 91500 39 / 31500 0.03 0.06 True +locoL_scratchsat_s162000_K1000 Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 205 / 12308 16 / 1898 -1.46 2.57 False +locoL_scratchsat_s162000_K1000 Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 32 / 3340 2 / 770 -0.25 1.61 False +locoL_scratchsat_s162000_K1000 Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 237 / 15648 52 / 4958 -1.22 1.45 False +locoL_scratchsat_s162000_K1000 Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 8326 / 310451 1095 / 59344 25 / 69000 1 / 10500 1.27 0.03 True +locoL_scratchsat_s162000_K1000 Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2362 / 98395 299 / 35572 5 / 22500 2 / 6000 1.72 -0.01 False +locoL_scratchsat_s162000_K1000 Granulocyte-like (LDG) all sepsis vs all controls 61 21 10688 / 408846 3649 / 180632 30 / 91500 5 / 31500 0.70 0.02 True +locoL_scratchsat_s162000_K1000 Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 12569 / 57131 1290 / 8702 249 / 12841 12 / 1206 4.69 0.96 True +locoL_scratchsat_s162000_K1000 Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 3420 / 15430 505 / 4363 38 / 3173 4 / 457 4.08 -0.12 False +locoL_scratchsat_s162000_K1000 Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 15989 / 72561 7340 / 38708 287 / 16014 54 / 4794 1.65 0.74 True + lora_n5__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3692 / 57131 136 / 8702 449 / 13060 47 / 1245 6.09 -0.47 False + lora_n5__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2291 / 15430 37 / 4363 121 / 3124 1 / 369 9.18 1.36 True + lora_n5__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5983 / 72561 629 / 38708 570 / 16184 99 / 5027 6.82 0.40 True + lora_n5__raw Cycling T/NK adult sepsis vs adult HC 46 7 1171 / 187719 146 / 44192 124 / 43294 14 / 8248 0.49 0.17 True + lora_n5__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 763 / 43733 427 / 24170 40 / 12279 10 / 4045 -0.17 0.17 False + lora_n5__raw Cycling T/NK all sepsis vs all controls 61 21 1934 / 231452 1397 / 114497 164 / 55573 47 / 20627 -0.34 0.13 False + lora_n5__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2223 / 162485 390 / 33194 128 / 40009 15 / 7765 0.44 0.17 True + lora_n5__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 956 / 40153 702 / 20916 36 / 11571 5 / 3883 -1.31 0.25 False + lora_n5__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3179 / 202638 2299 / 95479 164 / 51580 41 / 19452 -0.83 0.15 False + lora_n5__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 370 / 40009 73 / 7765 -0.06 0.08 False + lora_n5__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 152 / 11571 40 / 3883 -0.18 0.25 False + lora_n5__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 522 / 51580 181 / 19452 -0.62 0.18 False + lora_n5__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 421 / 69000 8 / 10500 0.97 0.53 True + lora_n5__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 225 / 22500 6 / 6000 -0.14 0.90 False + lora_n5__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 646 / 91500 66 / 31500 0.29 0.50 True + lora_n5__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 10788 / 310451 875 / 59344 567 / 69000 19 / 10500 1.78 0.64 True + lora_n5__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7043 / 98395 2902 / 35572 316 / 22500 14 / 6000 -1.40 1.17 False + lora_n5__raw Plasmablast (markers) all sepsis vs all controls 61 21 17831 / 408846 6889 / 180632 883 / 91500 115 / 31500 0.02 0.60 True + lora_n5__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11179 / 57131 44 / 8702 1180 / 13060 1 / 1245 17.78 4.36 True + lora_n5__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2546 / 15430 6 / 4363 841 / 3124 0 / 369 19.60 10.68 True + lora_n5__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 13725 / 72561 3611 / 38708 2021 / 16184 108 / 5027 10.57 4.91 True + lora_n5__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1876 / 57131 87 / 8702 160 / 13060 2 / 1245 1.94 0.52 True + lora_n5__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1638 / 15430 45 / 4363 67 / 3124 1 / 369 6.76 0.73 True + lora_n5__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3514 / 72561 542 / 38708 227 / 16184 8 / 5027 2.91 0.53 True + lora_n5__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8278 / 57131 1402 / 8702 1207 / 13060 30 / 1245 1.34 6.12 True + lora_n5__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5591 / 15430 1373 / 4363 544 / 3124 81 / 369 -6.52 -3.77 True + lora_n5__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 13869 / 72561 4834 / 38708 1751 / 16184 206 / 5027 2.18 3.71 True + lora_n5__raw ISG-high T adult sepsis vs adult HC 46 7 2840 / 162485 461 / 33194 361 / 40009 11 / 7765 1.61 0.88 True + lora_n5__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 2412 / 40153 3142 / 20916 302 / 11571 196 / 3883 -15.45 -3.45 True + lora_n5__raw ISG-high T all sepsis vs all controls 61 21 5252 / 202638 4511 / 95479 663 / 51580 235 / 19452 -1.67 0.07 False + lora_n5__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1672 / 47206 273 / 4301 214 / 9724 26 / 859 -0.87 -0.57 True + lora_n5__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1321 / 33660 271 / 4954 82 / 6524 10 / 1542 -1.09 0.84 False + lora_n5__raw DN2 / ABC B all sepsis vs all controls 61 21 2993 / 80866 1001 / 18863 296 / 16248 67 / 5123 -0.12 0.37 False + lora_n5__raw HSPC adult sepsis vs adult HC 46 7 387 / 310451 69 / 59344 69 / 69000 0 / 10500 0.00 0.10 True + lora_n5__raw HSPC paediatric sepsis vs paediatric HC 15 4 156 / 98395 26 / 35572 14 / 22500 5 / 6000 0.08 -0.02 False + lora_n5__raw HSPC all sepsis vs all controls 61 21 543 / 408846 184 / 180632 83 / 91500 24 / 31500 0.03 0.01 True + lora_n5__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1230 / 83070 412 / 13845 299 / 18428 113 / 3333 -1.43 -2.11 True + lora_n5__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 70 / 17697 43 / 8125 38 / 5392 15 / 2035 -0.26 -0.10 True + lora_n5__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1300 / 100767 758 / 39446 337 / 23820 181 / 9413 -1.20 -0.61 True + lora_n5__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 7606 / 310451 976 / 59344 63 / 69000 6 / 10500 1.20 0.03 True + lora_n5__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2119 / 98395 264 / 35572 16 / 22500 2 / 6000 1.56 0.04 True + lora_n5__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 9725 / 408846 3236 / 180632 79 / 91500 27 / 31500 0.69 0.00 True + lora_n5__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 10916 / 57131 1107 / 8702 1565 / 13060 73 / 1245 4.46 3.93 True + lora_n5__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 2976 / 15430 413 / 4363 280 / 3124 8 / 369 4.30 5.38 True + lora_n5__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 13892 / 72561 6160 / 38708 1845 / 16184 349 / 5027 2.18 2.44 True + real_lora__raw C1Q-high monocyte (reference) adult sepsis vs adult HC 46 7 3688 / 57131 135 / 8702 481 / 14056 18 / 1543 6.06 1.89 True + real_lora__raw C1Q-high monocyte (reference) paediatric sepsis vs paediatric HC 15 4 2285 / 15430 39 / 4363 122 / 3325 1 / 524 9.07 3.12 True + real_lora__raw C1Q-high monocyte (reference) all sepsis vs all controls 61 21 5973 / 72561 626 / 38708 603 / 17381 73 / 5342 6.77 2.05 True + real_lora__raw Cycling T/NK adult sepsis vs adult HC 46 7 1216 / 187719 151 / 44192 158 / 42538 28 / 8068 0.51 0.07 True + real_lora__raw Cycling T/NK paediatric sepsis vs paediatric HC 15 4 784 / 43733 454 / 24170 163 / 11841 31 / 4618 -0.24 0.55 False + real_lora__raw Cycling T/NK all sepsis vs all controls 61 21 2000 / 231452 1461 / 114497 321 / 54379 84 / 21199 -0.37 0.22 False + real_lora__raw Cycling activated T (CD38/HLA-DR) adult sepsis vs adult HC 46 7 2393 / 162485 419 / 33194 159 / 37951 24 / 6885 0.46 0.13 True + real_lora__raw Cycling activated T (CD38/HLA-DR) paediatric sepsis vs paediatric HC 15 4 1011 / 40153 748 / 20916 169 / 11014 27 / 4230 -1.41 0.71 False + real_lora__raw Cycling activated T (CD38/HLA-DR) all sepsis vs all controls 61 21 3404 / 202638 2456 / 95479 328 / 48965 68 / 18885 -0.89 0.34 False + real_lora__raw Proliferating T (label) adult sepsis vs adult HC 46 7 1725 / 162485 439 / 33194 374 / 37951 78 / 6885 -0.06 0.00 False + real_lora__raw Proliferating T (label) paediatric sepsis vs paediatric HC 15 4 1130 / 40153 542 / 20916 283 / 11014 57 / 4230 -0.18 0.94 False + real_lora__raw Proliferating T (label) all sepsis vs all controls 61 21 2855 / 202638 1938 / 95479 657 / 48965 189 / 18885 -0.62 0.41 False + real_lora__raw Plasmablast (label) adult sepsis vs adult HC 46 7 3601 / 310451 90 / 59344 704 / 69000 21 / 10500 0.97 0.82 True + real_lora__raw Plasmablast (label) paediatric sepsis vs paediatric HC 15 4 2779 / 98395 1000 / 35572 527 / 22500 21 / 6000 -0.14 1.99 False + real_lora__raw Plasmablast (label) all sepsis vs all controls 61 21 6380 / 408846 2043 / 180632 1231 / 91500 100 / 31500 0.29 1.03 True + real_lora__raw Plasmablast (markers) adult sepsis vs adult HC 46 7 11242 / 310451 955 / 59344 915 / 69000 37 / 10500 1.79 0.97 True + real_lora__raw Plasmablast (markers) paediatric sepsis vs paediatric HC 15 4 7387 / 98395 2989 / 35572 692 / 22500 44 / 6000 -1.30 2.34 False + real_lora__raw Plasmablast (markers) all sepsis vs all controls 61 21 18629 / 408846 7179 / 180632 1607 / 91500 196 / 31500 0.04 1.13 True + real_lora__raw MS1 monocyte (IL1R2+) adult sepsis vs adult HC 46 7 11171 / 57131 48 / 8702 1627 / 14056 2 / 1543 17.50 10.88 True + real_lora__raw MS1 monocyte (IL1R2+) paediatric sepsis vs paediatric HC 15 4 2544 / 15430 4 / 4363 554 / 3325 1 / 524 20.58 13.70 True + real_lora__raw MS1 monocyte (IL1R2+) all sepsis vs all controls 61 21 13715 / 72561 3647 / 38708 2181 / 17381 326 / 5342 10.53 8.69 True + real_lora__raw Cycling monocyte (Ye 2026) adult sepsis vs adult HC 46 7 1873 / 57131 90 / 8702 137 / 14056 2 / 1543 1.94 0.58 True + real_lora__raw Cycling monocyte (Ye 2026) paediatric sepsis vs paediatric HC 15 4 1636 / 15430 45 / 4363 33 / 3325 1 / 524 7.03 1.00 True + real_lora__raw Cycling monocyte (Ye 2026) all sepsis vs all controls 61 21 3509 / 72561 547 / 38708 170 / 17381 19 / 5342 3.01 0.48 True + real_lora__raw ISG-high monocyte (positive control) adult sepsis vs adult HC 46 7 8240 / 57131 1373 / 8702 1292 / 14056 54 / 1543 1.52 3.81 True + real_lora__raw ISG-high monocyte (positive control) paediatric sepsis vs paediatric HC 15 4 5620 / 15430 1380 / 4363 828 / 3325 74 / 524 -7.29 -12.70 True + real_lora__raw ISG-high monocyte (positive control) all sepsis vs all controls 61 21 13860 / 72561 4805 / 38708 2120 / 17381 212 / 5342 2.04 0.73 True + real_lora__raw ISG-high T adult sepsis vs adult HC 46 7 3214 / 162485 538 / 33194 299 / 37951 26 / 6885 1.69 0.45 True + real_lora__raw ISG-high T paediatric sepsis vs paediatric HC 15 4 2608 / 40153 3243 / 20916 413 / 11014 604 / 4230 -15.62 -7.75 True + real_lora__raw ISG-high T all sepsis vs all controls 61 21 5822 / 202638 4812 / 95479 712 / 48965 666 / 18885 -1.65 -0.92 True + real_lora__raw DN2 / ABC B adult sepsis vs adult HC 46 7 1691 / 47206 270 / 4301 138 / 9133 23 / 564 -0.88 -2.28 True + real_lora__raw DN2 / ABC B paediatric sepsis vs paediatric HC 15 4 1344 / 33660 276 / 4954 55 / 6769 15 / 702 -1.12 -1.46 True + real_lora__raw DN2 / ABC B all sepsis vs all controls 61 21 3035 / 80866 1001 / 18863 193 / 15902 56 / 3994 -0.12 -0.73 True + real_lora__raw HSPC adult sepsis vs adult HC 46 7 387 / 310451 68 / 59344 30 / 69000 11 / 10500 0.01 -0.06 False + real_lora__raw HSPC paediatric sepsis vs paediatric HC 15 4 157 / 98395 29 / 35572 8 / 22500 1 / 6000 0.07 0.02 True + real_lora__raw HSPC all sepsis vs all controls 61 21 544 / 408846 188 / 180632 38 / 91500 23 / 31500 0.03 -0.03 False + real_lora__raw Cytotoxic CD4 T adult sepsis vs adult HC 46 7 1249 / 83070 419 / 13845 356 / 17362 151 / 2655 -1.46 -3.62 True + real_lora__raw Cytotoxic CD4 T paediatric sepsis vs paediatric HC 15 4 71 / 17697 44 / 8125 26 / 4716 8 / 1677 -0.25 0.17 False + real_lora__raw Cytotoxic CD4 T all sepsis vs all controls 61 21 1320 / 100767 771 / 39446 382 / 22078 227 / 8168 -1.22 -1.19 True + real_lora__raw Granulocyte-like (LDG) adult sepsis vs adult HC 46 7 7984 / 310451 1038 / 59344 118 / 69000 13 / 10500 1.24 0.05 True + real_lora__raw Granulocyte-like (LDG) paediatric sepsis vs paediatric HC 15 4 2236 / 98395 290 / 35572 57 / 22500 2 / 6000 1.61 0.22 True + real_lora__raw Granulocyte-like (LDG) all sepsis vs all controls 61 21 10220 / 408846 3460 / 180632 175 / 91500 21 / 31500 0.69 0.12 True + real_lora__raw Platelet signal in monocytes (negative control) adult sepsis vs adult HC 46 7 10975 / 57131 1091 / 8702 1521 / 14056 111 / 1543 4.49 3.32 True + real_lora__raw Platelet signal in monocytes (negative control) paediatric sepsis vs paediatric HC 15 4 2946 / 15430 401 / 4363 309 / 3325 35 / 524 4.29 1.97 True + real_lora__raw Platelet signal in monocytes (negative control) all sepsis vs all controls 61 21 13921 / 72561 6142 / 38708 1830 / 17381 478 / 5342 2.03 2.21 True diff --git a/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_driver.log b/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_driver.log new file mode 100644 index 0000000000000000000000000000000000000000..385a6157f2a93d5b704bbcdcf74f62abe8e3b4c1 --- /dev/null +++ b/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_driver.log @@ -0,0 +1,19 @@ +2026-10-05T21:59:37+09:00 xcalL_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/xcal_K1000.npz +2026-10-05T21:59:58+09:00 xcalL_K1000: {"arm": "xcalL_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 1628.0} +2026-10-05T21:59:59+09:00 locoL_lora16sat_s26750_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_lora16sat_s26750.npz +2026-10-05T22:00:19+09:00 locoL_lora16sat_s26750_K1000: {"arm": "locoL_lora16sat_s26750_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 1135.0} +2026-10-05T22:00:20+09:00 locoL_lora64sat_s59000_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_lora64sat_s59000.npz +2026-10-05T22:00:41+09:00 locoL_lora64sat_s59000_K1000: {"arm": "locoL_lora64sat_s59000_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 1013.0} +2026-10-05T22:00:42+09:00 locoL_fullsat_s20000_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_fullsat_s20000.npz +2026-10-05T22:01:03+09:00 locoL_fullsat_s20000_K1000: {"arm": "locoL_fullsat_s20000_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 1070.0} +2026-10-05T22:01:03+09:00 locoL_fullsat_s108500_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_fullsat_s108500.npz +2026-10-05T22:01:25+09:00 locoL_fullsat_s108500_K1000: {"arm": "locoL_fullsat_s108500_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 1055.0} +2026-10-05T22:01:26+09:00 locoL_scratchsat_s50000_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_scratchsat_s50000.npz +2026-10-05T22:01:46+09:00 locoL_scratchsat_s50000_K1000: {"arm": "locoL_scratchsat_s50000_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 13891.0} +2026-10-05T22:01:47+09:00 locoL_scratchsat_s100000_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_scratchsat_s100000.npz +2026-10-05T22:02:08+09:00 locoL_scratchsat_s100000_K1000: {"arm": "locoL_scratchsat_s100000_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 19138.0} +2026-10-05T22:02:09+09:00 locoL_scratchsat_s150000_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_scratchsat_s150000.npz +2026-10-05T22:02:29+09:00 locoL_scratchsat_s150000_K1000: {"arm": "locoL_scratchsat_s150000_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 20524.0} +2026-10-05T22:02:29+09:00 locoL_scratchsat_s162000_K1000: extracting from spark-0110:/home/sj_server_1/PBISC/immun-pbmc-fm/model_8_sparse_data_diffusion/plans/paired_crosscohort_20261002/generated/ye2026_sepsis/hoL_ye2026_sepsis/K1000_scratchsat_s162000.npz +2026-10-05T22:02:50+09:00 locoL_scratchsat_s162000_K1000: {"arm": "locoL_scratchsat_s162000_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 20606.0} +2026-10-05T22:02:50+09:00 done; failed=0 diff --git a/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_locoL_fullsat_s108500_K1000.err b/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_locoL_fullsat_s108500_K1000.err new file mode 100644 index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391 diff --git a/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_locoL_fullsat_s108500_K1000.log b/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_locoL_fullsat_s108500_K1000.log new file mode 100644 index 0000000000000000000000000000000000000000..008fda2aa74bf7f88c2f0de8e3e508fca8d5aa5f --- /dev/null +++ b/paper-releases/pbisc-diffusion/updates/20261005T142225Z-rare-states-scratch-vs-pretrained/diffusion/dataset/server_1/model8/plans/rare_states_screen_20261004/logs/loco_extract_locoL_fullsat_s108500_K1000.log @@ -0,0 +1 @@ +{"arm": "locoL_fullsat_s108500_K1000", "sha256_ok": true, "cells": 123000, "donors": 82, "poisson_reproduced": true, "median_lib_measured": 1055.0}