{
  "entities": [
    {
      "label": "anatomical system",
      "description": "A connected anatomical system made up of multiple organs or structures."
    },
    {
      "label": "cell",
      "description": "A cell or cell population mentioned in the text."
    },
    {
      "label": "cellular component",
      "description": "A component or structure within a cell."
    },
    {
      "label": "developing anatomical structure",
      "description": "An anatomical structure described during development."
    },
    {
      "label": "dna domain or region",
      "description": "A named or described domain or region of DNA."
    },
    {
      "label": "drug or compound",
      "description": "A drug, chemical compound, or other administered substance."
    },
    {
      "label": "gene or gene product",
      "description": "A gene, RNA, protein, or gene product mention."
    },
    {
      "label": "immaterial anatomical entity",
      "description": "A non-material anatomical feature such as a boundary or space."
    },
    {
      "label": "multi-tissue structure",
      "description": "An anatomical structure composed of more than one tissue type."
    },
    {
      "label": "organ",
      "description": "A distinct anatomical organ."
    },
    {
      "label": "organism",
      "description": "An organism or organism population."
    },
    {
      "label": "organism subdivision",
      "description": "A subdivision or region of an organism."
    },
    {
      "label": "organism substance",
      "description": "A naturally occurring substance produced by or found in an organism."
    },
    {
      "label": "pathological formation",
      "description": "A pathological anatomical formation, lesion, or disease-associated structure."
    },
    {
      "label": "protein domain or region",
      "description": "A domain, region, or site within a protein."
    },
    {
      "label": "tissue",
      "description": "A tissue or tissue population."
    }
  ],
  "json_structures": [
    {
      "label": "Acetylation",
      "description": "Addition of an acetyl group to a biological molecule.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Binding",
      "description": "Association of two or more biological participants.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Site",
          "description": "The site on the theme where the event occurs."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        },
        {
          "label": "Theme2",
          "description": "The primary participant or event affected by the event; Theme2 distinguishes an additional filler of the same role."
        }
      ]
    },
    {
      "label": "Blood_vessel_development",
      "description": "Formation or development of blood vessels.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "AtLoc",
          "description": "The location at which the event or its theme is situated."
        },
        {
          "label": "FromLoc",
          "description": "The source location from which a participant moves."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Breakdown",
      "description": "Breakdown or disassembly of a biological structure or material.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Catabolism",
      "description": "Catabolic processing or degradation of a biological participant.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Cell_division",
      "description": "Division of a cell into daughter cells.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Cell_proliferation",
      "description": "Increase in the number of cells through proliferation.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "DNA_methylation",
      "description": "Addition of methyl groups to DNA.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Site",
          "description": "The site on the theme where the event occurs."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Death",
      "description": "Death of a cell, tissue, organism, or other biological participant.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Dephosphorylation",
      "description": "Removal of a phosphate group from a biological molecule.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Site",
          "description": "The site on the theme where the event occurs."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Development",
      "description": "Development or maturation of a biological structure or organism.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Dissociation",
      "description": "Separation of previously associated biological participants.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Gene_expression",
      "description": "Expression or production of a gene product.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Growth",
      "description": "Increase in size or extent of a biological participant.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Localization",
      "description": "Presence or movement of a biological participant at or to a location.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "AtLoc",
          "description": "The location at which the event or its theme is situated."
        },
        {
          "label": "FromLoc",
          "description": "The source location from which a participant moves."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        },
        {
          "label": "ToLoc",
          "description": "The destination location to which a participant moves."
        }
      ]
    },
    {
      "label": "Metabolism",
      "description": "A metabolic process involving biological material.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Negative_regulation",
      "description": "Regulation that decreases, suppresses, or prevents its theme.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "CSite",
          "description": "The site on the cause that participates in a regulatory event."
        },
        {
          "label": "Cause",
          "description": "The participant or event responsible for causing or regulating the event."
        },
        {
          "label": "Site",
          "description": "The site on the theme where the event occurs."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Pathway",
      "description": "A biological pathway or linked sequence of processes.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Participant",
          "description": "A participant involved in the event."
        },
        {
          "label": "Participant2",
          "description": "A participant involved in the event; Participant2 distinguishes an additional filler of the same role."
        },
        {
          "label": "Participant3",
          "description": "A participant involved in the event; Participant3 distinguishes an additional filler of the same role."
        },
        {
          "label": "Participant4",
          "description": "A participant involved in the event; Participant4 distinguishes an additional filler of the same role."
        }
      ]
    },
    {
      "label": "Phosphorylation",
      "description": "Addition of a phosphate group to a biological molecule.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Site",
          "description": "The site on the theme where the event occurs."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Planned_process",
      "description": "An experimentally or clinically planned biological process.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Instrument",
          "description": "An instrument, treatment, or means used in the event."
        },
        {
          "label": "Instrument2",
          "description": "An instrument, treatment, or means used in the event; Instrument2 distinguishes an additional filler of the same role."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        },
        {
          "label": "Theme2",
          "description": "The primary participant or event affected by the event; Theme2 distinguishes an additional filler of the same role."
        }
      ]
    },
    {
      "label": "Positive_regulation",
      "description": "Regulation that increases, promotes, or enables its theme.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "CSite",
          "description": "The site on the cause that participates in a regulatory event."
        },
        {
          "label": "Cause",
          "description": "The participant or event responsible for causing or regulating the event."
        },
        {
          "label": "Site",
          "description": "The site on the theme where the event occurs."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        },
        {
          "label": "Theme2",
          "description": "The primary participant or event affected by the event; Theme2 distinguishes an additional filler of the same role."
        }
      ]
    },
    {
      "label": "Protein_processing",
      "description": "Processing or maturation of a protein product.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Regulation",
      "description": "Regulation whose positive or negative direction is not specified.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "CSite",
          "description": "The site on the cause that participates in a regulatory event."
        },
        {
          "label": "Cause",
          "description": "The participant or event responsible for causing or regulating the event."
        },
        {
          "label": "Site",
          "description": "The site on the theme where the event occurs."
        },
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Remodeling",
      "description": "Remodeling or structural reorganization of biological material.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Reproduction",
      "description": "A reproductive biological process.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Synthesis",
      "description": "Synthesis or production of a biological participant.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Transcription",
      "description": "Transcription of a gene or DNA template into RNA.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Translation",
      "description": "Translation of RNA into a protein product.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    },
    {
      "label": "Ubiquitination",
      "description": "Addition of ubiquitin to a protein or other biological molecule.",
      "anchor": "trigger",
      "anchor_description": "The word or phrase that expresses the event.",
      "roles": [
        {
          "label": "Theme",
          "description": "The primary participant or event affected by the event."
        }
      ]
    }
  ]
}