input stringlengths 304 2.65k | output dict | schema listlengths 0 0 |
|---|---|---|
Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor.
A marked coronary angiogenesis is known to occur with chronic bradycardia. We tested the hypothesis that vascular endothelial growth factor (VEGF), an endothelial cell mitogen and a major regulator of angiogenesis, is upregul... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 29,
"end": 41
},
"arguments": [
{
"role": "Theme",
"text": "coronary",
"start": 20,
"end": 28
... | [] |
External beam radiotherapy for subretinal neovascularization in age-related macular degeneration: is this treatment efficient?
PURPOSE: Control of the natural course of subretinal neovascularization (SRNV) in age-related macular degeneration (AMD) is difficult. Only a subset of patients is suitable for laser coagulati... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neovascularization",
"start": 42,
"end": 60
},
"arguments": []
},
{
"trigger": {
"text": "neovascularization",
"start": 181,
"e... | [] |
Increased serum levels of vascular endothelial growth factor in patients with renal cell carcinoma.
Neovascularization, an essential event for the growth of solid tumors, is regulated by a number of angiogenic factors. One such factor, vascular endothelial growth factor (VEGF), is considered to exert a potent angiogen... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "Neovascularization",
"start": 101,
"end": 119
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 200,
"end": 2... | [] |
Insulin-induced vascular endothelial growth factor expression in retina.
PURPOSE: Clinical studies have demonstrated that intensive insulin therapy causes a transient worsening of retinopathy. The mechanisms underlying the initial insulin-induced deterioration of retinal status in patients with diabetes remain unknown... | {
"json_structures": {
"Cell_proliferation": [
{
"trigger": {
"text": "proliferation",
"start": 1019,
"end": 1032
},
"arguments": [
{
"role": "Theme",
"text": "capillary endothelial cell",
"start": 992,
... | [] |
The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice.
The aim of this study was to ascertain the potential usefulness of the antiangiogenic compound linomide for treatment of von Hippel-Lindau (VHL)-related tumors. Paraganglioma tissue fragments obtained at s... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenic",
"start": 8,
"end": 18
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 190,
"end": 200
... | [] |
Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis.
Long-term peritoneal dialysis (PD) is associated with alterations in peritoneal permeability and loss of ultrafiltration. These changes originate from increased peritoneal s... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1750,
"end": 1762
},
"arguments": []
}
],
"Development": [
{
"trigger": {
"text": "proliferation",
"start... | [] |
Active hair growth (anagen) is associated with angiogenesis.
After the completion of skin development, angiogenesis, i.e., the growth of new capillaries from pre-existing blood vessels, is held to occur in the skin only under pathologic conditions. It has long been noted, however, that hair follicle cycling is associa... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 47,
"end": 59
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 104,
"end": 116
... | [] |
Alpha-melanocyte-stimulating hormone modulates activation of NF-kappa B and AP-1 and secretion of interleukin-8 in human dermal fibroblasts.
Alpha-melanocyte-stimulating hormone (alpha-MSH) has evolved as a mediator of diverse biological activities in an ever-growing number of non-melanocytic cell types. One mechanism... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binding",
"start": 849,
"end": 856
},
"arguments": [
{
"role": "Theme",
"text": "NF-kappa B",
"start": 812,
"end": 822
}
... | [] |
Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells.
Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial re... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "bind",
"start": 798,
"end": 802
},
"arguments": [
{
"role": "Theme",
"text": "VASP",
"start": 768,
"end": 772
},
{
... | [] |
Urokinase receptor: a molecular organizer in cellular communication.
In a variety of cell types, the glycolipid-anchored urokinase receptor (uPAR) is colocalized pericellularly with components of the plasminogen activation system and endocytosis receptors. uPAR is also coexpressed with caveolin and members of the inte... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "adhesive processes",
"start": 565,
"end": 583
},
"arguments": [
{
"role": "Theme",
"text": "cell",
"start": 560,
"end": 564
}
... | [] |
RNA damage and inhibition of neoplastic endothelial cell growth: effects of human and amphibian ribonucleases.
Angiogenesis defines the many steps involved in the growth and migration of endothelial cell-derived blood vessels. This process is necessary for the growth and metastasis of tumors, and considerable effort i... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "Angiogenesis",
"start": 112,
"end": 124
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 365,
"end": 377
... | [] |
IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk.
In vivo IL-12-dependent tumor inhibition rests on the ability of IL-12 to activate a CD8-mediated cytotoxicity, inhibit angiogenesis, and cause vascular injury. Although in vivo studies have shown that su... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "adhere",
"start": 871,
"end": 877
},
"arguments": [
{
"role": "Theme",
"text": "EC",
"start": 865,
"end": 867
},
{
... | [] |
Effects of morphological patterning on endothelial cell migration.
The migration of vascular endothelial cells (ECs) plays an important role in vascular remodeling. Here we studied the effects of cell morphology on the migration of bovine aortic ECs by culturing cells on micropatterned strips of collagen matrix (60-, ... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1230,
"end": 1242
},
"arguments": []
}
],
"Localization": [
{
"trigger": {
"text": "migration",
"start": ... | [] |
Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism.
The angiogenic switch during tumorigenesis is thought to be induced by a change in the balance of pro- angiogenic and anti-angiogenic factors. To elucidate the biological role of the endogenous angiogenesis... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenic",
"start": 118,
"end": 128
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 217,
"end": 227
... | [] |
Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs.
In animal or cell culture studies, the growth and spread of cancer can be slowed by many nutrients, food factors, herbal extracts, and well-tolerated, available drugs that are sti... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1109,
"end": 1121
},
"arguments": []
}
],
"Growth": [
{
"trigger": {
"text": "growth",
"start": 41,
... | [] |
Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors.
Interactions among growth factors, cells, and extracellular matrix regulate proliferation during normal development and in pathol... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "Interactions",
"start": 191,
"end": 203
},
"arguments": [
{
"role": "Theme",
"text": "cells",
"start": 226,
"end": 231
},
... | [] |
Upregulation of vascular endothelial growth factor receptors is associated with advanced neuroblastoma.
BACKGROUND: Angiogenesis is essential for tumor growth and relies on the production of angiogenic factors. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis that binds to tyrosine kinase... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binds",
"start": 296,
"end": 301
},
"arguments": [
{
"role": "Theme",
"text": "Vascular endothelial growth factor",
"start": 212,
"end":... | [] |
Optimizing treatment of choroidal neovascularization feeder vessels associated with age-related macular degeneration.
PURPOSE: To optimize the method of treating choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD). DESIGN: Experimental study and interventional case series. METHODS... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neovascularization",
"start": 34,
"end": 52
},
"arguments": [
{
"role": "Theme",
"text": "feeder vessels",
"start": 53,
... | [] |
Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid.
Dietary conjugated linoleic acid (CLA) has been shown previously to inhibit rat mammary carcinogenesis. In addition to direct effects on mammary epithelial cells,including decreased proliferation and induction of apoptosis, CLA ma... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 14,
"end": 26
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 682,
"end": 694
... | [] |
Molecular characterization of angiogenic properties of human oral squamous cell carcinoma cells.
Little is known about the specificity of angiogenic properties of oral cancer cells and the possible mechanisms. Stimulatory effects on proliferation and migration of human umbilical vein endothelial cells (HUVEC) characte... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenic",
"start": 30,
"end": 40
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 139,
"end": 149
... | [] |
Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model.
Homeostasis of the extracellular matrix is a delicate balance between degradation and remodeling, the balance being maintained by the interaction of activa... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interaction",
"start": 299,
"end": 310
},
"arguments": [
{
"role": "Theme",
"text": "matrix metalloproteinases",
"start": 324,
"end": 34... | [] |
Brn-3a, a neuronal transcription factor of the POU gene family: indications for its involvement in cancer and angiogenesis.
Brn-3a, a member of the POU gene family (so-called because of the similarity with the group of transcription factors Pit, Oct, and Unc), was found in neuronal cells engaged in the transcription a... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 110,
"end": 122
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 1088,
"end": 1100... | [] |
Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats.
Roles of cell adhesion molecules mediating the interaction of cancer and endothelial cells in tumor angiogenesis were investigated using new in vitro and in vivo model systems with a cultur... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interaction",
"start": 178,
"end": 189
},
"arguments": [
{
"role": "Theme",
"text": "cancer",
"start": 193,
"end": 199
},
... | [] |
Regulation of transforming growth factor-beta signaling and vascular diseases.
PURPOSE: Members of the transforming growth factor (TGF)-beta superfamily play critical roles in regulation of various cellular functions. Dysregulation of the signaling mechanisms of the TGF-beta superfamily proteins is associated with cli... | {
"json_structures": {
"Negative_regulation": [
{
"trigger": {
"text": "inhibitory",
"start": 784,
"end": 794
},
"arguments": [
{
"role": "Theme",
"text": "Smads",
"start": 795,
"end": 800
... | [] |
Arteriogenesis: the development and growth of collateral arteries.
In patients with atherosclerotic vascular diseases, collateral vessels bypassing major arterial obstructions have frequently been observed. This may explain why some patients remain without symptoms or signs of ischemia. The term "arteriogenesis" was i... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "Arteriogenesis",
"start": 0,
"end": 14
},
"arguments": [
{
"role": "Theme",
"text": "collateral arteries",
"start": 46,
... | [] |
Possible role of cyclooxygenase II in the acquisition of ovarian luteal function in rodents.
The development of the corpus luteum (CL), which involves angiogenesis, is essential for the establishment of early pregnancy. We investigated the roles of the prostaglandin synthases cyclooxygenase (COX) I and COX-II in angio... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 152,
"end": 164
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 315,
"end": 327
... | [] |
Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression.
The expression of endothelial cell (EC) adhesion molecules involved in leukocyte-vessel wall interactions is suppressed in malignancies. In the present study, we investigated in vivo the regula... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interactions",
"start": 51,
"end": 63
},
"arguments": [
{
"role": "Theme",
"text": "leukocyte",
"start": 29,
"end": 38
},
... | [] |
Prognostic value of p53 protein expression and vascular endothelial growth factor expression in resected squamous cell carcinoma of the esophagus.
The most common genetic alterations found in a wide variety of cancers are p53 tumor suppressor gene mutations. p53 appears to be a nuclear transcription factor that plays ... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "Angiogenesis",
"start": 418,
"end": 430
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 587,
"end": 597
... | [] |
The role of organ vascularization and lipoplex-serum initial contact in intravenous murine lipofection.
Following intravenous administration of cationic lipid-DNA complexes (lipoplexes) into mice, transfection (lipofection) occurs predominantly in the lungs. This was attributed to high entrapment of lipoplexes in the ... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "aggregate",
"start": 1340,
"end": 1349
},
"arguments": [
{
"role": "Theme",
"text": "lipoplexes",
"start": 1269,
"end": 1279
}... | [] |
Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. a pilot study.
Retinopathy is the most common microvascular diabetes complication and represents a major threat to the eyesight. The aim of this study... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenic",
"start": 93,
"end": 103
},
"arguments": [
{
"role": "AtLoc",
"text": "ocular",
"start": 81,
"end": 87
... | [] |
Angiogenesis--biomedical technology.
All of these studies show that angiogenesis research can benefit from new biomedical technology tools currently being developed, as well as contribute by providing new technologies that can be used in other areas of medicine. It is hoped that the chapters in this book in this area ... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "Angiogenesis",
"start": 0,
"end": 12
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 69,
"end": 81
... | [] |
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat.
Interleukin-1 (IL-1) synthesis in the brain is stimulated by mechanical injury and IL-1 mimics some effects of injury, such as gliosis and neovascularization. We report that neuronal death resulting from focal cerebral isc... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neovascularization",
"start": 237,
"end": 255
},
"arguments": []
}
],
"Breakdown": [
{
"trigger": {
"text": "damage",
"start": 78... | [] |
Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells.
The interaction between the vascular endothelium and hemodynamic forces (and more specifically, fluid shear stress), induced by the flow of blood, plays a major role in vascular remodeling ... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binding",
"start": 779,
"end": 786
},
"arguments": [
{
"role": "Theme",
"text": "Tie1",
"start": 802,
"end": 806
},
... | [] |
Therapeutic angiogenesis: a complex problem requiring a sophisticated approach.
Blood and vascular disorders underlie a plethora of pathologic conditions and are the single most frequent cause of human disease. Ischemia, involving restricted blood flow to tissues is the most common consequence of vessel dysfunction re... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 12,
"end": 24
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 1782,
"end": 1792
... | [] |
Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels.
The vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor (IGF-1R), and multiple binding proteins. This growth factor system exerts multiple physiologic effects on the vasculature thro... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interactions",
"start": 469,
"end": 481
},
"arguments": [
{
"role": "Theme",
"text": "IGF-1",
"start": 390,
"end": 395
},
... | [] |
Morphogenesis of embryonic CNS vessels.
This chapter focuses on the morphology of blood vessel formation in and around the early central nervous system (CNS, i.e., brain and spinal cord) of avian embryos. We discuss cell lineages, proliferation and interactions of endothelial cells, pericytes and smooth muscle cells, ... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interactions",
"start": 250,
"end": 262
},
"arguments": [
{
"role": "Theme",
"text": "endothelial cells",
"start": 266,
"end": 283
... | [] |
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Gliomas are the most common primary tumours of the central nervous system, with nearly 15,000 diagnosed annually in the United States and a lethality approaching 80% within the first year of glioblastoma diagnosis. The marked ... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interacts",
"start": 1086,
"end": 1095
},
"arguments": [
{
"role": "Theme",
"text": "ING4",
"start": 1070,
"end": 1074
},
... | [] |
TGFbeta1, back to the future: revisiting its role as a transforming growth factor.
TGFbeta1 was initially identified in culture media from transformed cells as part of a factor that could produce a transformed phenotype in a nontransformed cell line. Subsequently this activity was separated into TGFbeta and TGFalpha a... | {
"json_structures": {
"Gene_expression": [
{
"trigger": {
"text": "overexpress",
"start": 653,
"end": 664
},
"arguments": [
{
"role": "Theme",
"text": "TGFbeta1",
"start": 665,
"end": 673
... | [] |
Role of thrombin in angiogenesis and tumor progression.
Clinical, laboratory, histopathological, and pharmacological evidence support the notion that the coagulation system, which is activated in most cancer patients, plays an important role in tumor biology. Our laboratory has provided evidence that thrombin activate... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "attach",
"start": 597,
"end": 603
},
"arguments": [
{
"role": "Theme",
"text": "Thrombin",
"start": 542,
"end": 550
},
... | [] |
Matrix metalloproteinase activity and immunohistochemical profile of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 during human dermal wound healing.
Proteolytic activity is required for the turnover of the extracellular matrix during wound healing. Matrix metalloproteinases can collect... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1641,
"end": 1653
},
"arguments": []
}
],
"Breakdown": [
{
"trigger": {
"text": "cleave",
"start": 326,
... | [] |
Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation.
The functional benefit of cell transplantation after a myocardial infarction is diminished by early cell losses. IGF-1 enhances cell proliferation and survival. We hypothesized that IGF-1-transfected smooth muscle cells (SMCs... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 851,
"end": 863
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 1744,
"end": 1756... | [] |
[Glaucoma and ocular ischemic syndrome--case report]
PURPOSE: Ocular ischemic syndrome (OIS) is often poorly diagnosed and treated as primary open angle glaucoma or later on, as neovascular glaucoma. We present a 54 year old male, treated topical since 23 years for glaucoma and sent to our clinic for trabeculectomy be... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neovascularization",
"start": 511,
"end": 529
},
"arguments": [
{
"role": "AtLoc",
"text": "iris",
"start": 506,
"end":... | [] |
Hypoxia-responsive element-mediated soluble Tie2 vector exhibits an anti-angiogenic activity in vitro under hypoxic condition.
Hypoxia-inducible factor-1 (HIF-1) is one of the key mammalian transcription factors and shows increased levels in both protein stability and intrinsic transcriptional activity during low oxyg... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binds",
"start": 375,
"end": 380
},
"arguments": [
{
"role": "Theme2",
"text": "HIF-1",
"start": 361,
"end": 366
},
... | [] |
2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.
PURPOSE: Head and neck squamous cell carcinomas have been reported to overexpress hypoxia-inducible factor (HIF)-1alpha, a transcription factor that pro... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binding",
"start": 1240,
"end": 1247
},
"arguments": [
{
"role": "Theme",
"text": "HIF-1alpha",
"start": 1229,
"end": 1239
}
... | [] |
Expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 for inhibitor screening.
Vascular endothelial growth factor (VEGF), an endothelial cell-specific mitogen, can act in tumor-induced angiogenesis by binding to specific receptors on the surface of endothelial cells... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binding",
"start": 255,
"end": 262
},
"arguments": [
{
"role": "Theme",
"text": "Vascular endothelial growth factor",
"start": 133,
"end... | [] |
Novel biological agents for the treatment of hormone-refractory prostate cancer (HRPC).
Hormone-refractory prostate cancer (HRPC) is an inevitable evolution of prostate carcinogenesis, through which the normal dependence on hormones for growth and survival is bypassed. Although advances in terms of symptoms palliation... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 902,
"end": 914
},
"arguments": []
}
],
"Development": [
{
"trigger": {
"text": "carcinogenesis",
"start"... | [] |
Role of thrombogenic factors in the development of atherosclerosis.
Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autop... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "aggregation",
"start": 785,
"end": 796
},
"arguments": [
{
"role": "Theme",
"text": "platelet",
"start": 776,
"end": 784
}
... | [] |
Rofecoxib as adjunctive therapy for haemophilic arthropathy.
Joint haemorrhage and subsequent haemophilic arthropathy are significant complications in haemophilia. The pathophysiology involves inflammation and angiogenesis. Cyclooxygenase-2 (COX-2) inhibitors are anti-inflammatory agents, which have potent anti-inflam... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 211,
"end": 223
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 333,
"end": 343
... | [] |
Thalidomide and angiostatin inhibit tumor growth in a murine xenograft model of human cervical cancer.
OBJECTIVE: To determine the impact of thalidomide and angiostatin on tumor growth, angiogenesis, and apoptosis in a xenograft model of cervical cancer. METHODS: Human umbilical endothelial cells were treated with ang... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 187,
"end": 199
},
"arguments": [
{
"role": "AtLoc",
"text": "cervical cancer",
"start": 239,
"... | [] |
Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis.
BACKGROUND: The effects of a rectified semi-sinewave signal (15 mT amplitude, 120 pulses per second, EMF Therapeutics, Inc.) (TEMF) alone and in combination with gamma irradiation (IR) t... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 104,
"end": 116
},
"arguments": [
{
"role": "AtLoc",
"text": "breast cancer xenograft",
"start": 72,
... | [] |
The merits of vascular targeting for gynecologic malignancies.
Neovascularization is an early and critical step in tumor development and progression. Tumor vessels are distinct from their normal counterparts morphologically as well as at a molecular level. Recent studies on factors involved in tumor vascular developme... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "Neovascularization",
"start": 64,
"end": 82
},
"arguments": []
},
{
"trigger": {
"text": "neovascularization",
"start": 384,
"e... | [] |
Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt.
Domain 5 (D5) of cleaved high molecular weight kininogen (HKa) inhibits angiogenesis in vivo and endothelial cell migration in vitro, but the cell signaling pathways involved in HKa and D5 inhibition of endothelial cel... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 174,
"end": 186
},
"arguments": []
}
],
"Localization": [
{
"trigger": {
"text": "migration",
"start": 78... | [] |
Effect of thalidomide affecting VEGF secretion, cell migration, adhesion and capillary tube formation of human endothelial EA.hy 926 cells.
Angiogenesis, new blood vessel formation, is a multistep process, precisely regulated by pro-angiogenic cytokines, which stimulate endothelial cells to migrate, proliferate and di... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "adhesion",
"start": 64,
"end": 72
},
"arguments": [
{
"role": "Theme",
"text": "endothelial EA.hy 926 cells",
"start": 111,
"end": 138
... | [] |
Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCalpha.
Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the f... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 36,
"end": 48
},
"arguments": [
{
"role": "Theme",
"text": "skin microvasculature",
"start": 14,
... | [] |
The differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor may contribute to the clinically more aggressive behavior of p63-positive breast carcinomas.
p63, a p53 homologue, is a myoepithelial cell marker in the normal mammary gland but p63-positive neoplastic cells ma... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1429,
"end": 1441
},
"arguments": []
}
],
"Development": [
{
"trigger": {
"text": "differentiated",
"star... | [] |
Regulation of tumor angiogenesis by thrombospondin-1.
Angiogenesis plays a critical role in the growth and metastasis of tumors. Thrombospondin-1 (TSP-1) is a potent angiogenesis inhibitor, and down-regulation of TSP-1 has been suggested to alter tumor growth by modulating angiogenesis in a variety of tumor types. Exp... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 20,
"end": 32
},
"arguments": [
{
"role": "AtLoc",
"text": "tumor",
"start": 14,
"end": 19
... | [] |
Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression.
Low density lipoprotein receptor-related protein-1 (LRP-1) is a catabolic receptor for extracellular matrix (ECM) structural proteins and for proteins that... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "bind",
"start": 321,
"end": 325
},
"arguments": [
{
"role": "Theme",
"text": "ECM",
"start": 329,
"end": 332
}
]
... | [] |
Pericytes limit tumor cell metastasis.
Previously we observed that neural cell adhesion molecule (NCAM) deficiency in beta tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient beta cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-c... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "cell-cell interactions",
"start": 314,
"end": 336
},
"arguments": [
{
"role": "Theme",
"text": "pericyte",
"start": 293,
"end": 301
... | [] |
NF-kappaB and IKK as therapeutic targets in cancer.
The transcription factor NF-kappaB and associated regulatory factors (including IkappaB kinase subunits and the IkappaB family member Bcl-3) are strongly implicated in a variety of hematologic and solid tumor malignancies. A role for NF-kappaB in cancer cells appears... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "associated",
"start": 92,
"end": 102
},
"arguments": [
{
"role": "Theme",
"text": "NF-kappaB",
"start": 78,
"end": 87
},
... | [] |
Circulating endothelial cells in malignant disease.
Cancer is a disease largely dependent on neoangiogenesis. Cancer neoangiogenesis is often disordered and abnormal, with evidence of coexisting vascular endothelial dysfunction. A novel method of assessing vascular endothelial function in cancer is via the quantificat... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neoangiogenesis",
"start": 94,
"end": 109
},
"arguments": []
},
{
"trigger": {
"text": "neoangiogenesis",
"start": 118,
"end": ... | [] |
GDP and AGE receptors: mechanisms of peritoneal damage.
Long-term peritoneal dialysis (PD) is limited by morphological changes of the peritoneal membrane. Structural changes were promoted by toxicity of glucose degradation products (GDPs) which are generated during heat sterilization in peritoneal dialysis fluids (PDF... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neoangiogenesis",
"start": 787,
"end": 802
},
"arguments": [
{
"role": "AtLoc",
"text": "peritoneal membrane",
"start": 824,
... | [] |
[Autologous bone marrow stem cell or peripheral blood endothelial progenitor cell therapy in patients with peripheral limb ischaemia]
No effective medical therapies have been developed sofar to enhance blood flow in the legs of patients with peripheral arterial disease (PAD). For patients with limb threatening ischaem... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neoangiogenesis",
"start": 581,
"end": 596
},
"arguments": []
},
{
"trigger": {
"text": "neovascularization",
"start": 600,
"en... | [] |
Formation of new bone during vertical distraction osteogenesis of the human mandible is related to the presence of blood vessels.
We examined the effect of distraction rate on blood vessel growth in intramembraneous ossification after vertical distraction osteogenesis in the human mandible. Six edentulous patients (ag... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1151,
"end": 1163
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 1592,
"end": 16... | [] |
Imaging tumor angiogenesis.
Since the discovery of vascular-specific growth factors with angiogenic activity, there has been a significant effort to develop cancer drugs that restrict tumorigenesis by targeting the blood supply. In this issue of the JCI, Mancuso et al. use mouse models to better understand the plastic... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 14,
"end": 26
},
"arguments": [
{
"role": "AtLoc",
"text": "tumor",
"start": 8,
"end": 13
... | [] |
Collagen-poly glycolic acid hybrid matrix with basic fibroblast growth factor accelerated angiogenesis and granulation tissue formation in diabetic mice.
Because poor skin wound healing associated with diabetes is thought to be partly a result from impaired angiogenesis, treatments that improve angiogenesis could have... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 90,
"end": 102
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 259,
"end": 271
... | [] |
Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer.
The last 7 years have seen over seven times as many publications indexed by Medline dealing with pomegranate and Punica granatum than in all the years preceding them. Because of this, and the virtual explosion of i... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1180,
"end": 1192
},
"arguments": []
}
],
"Cell_proliferation": [
{
"trigger": {
"text": "proliferation",
... | [] |
Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.
20-Hydroxyeicosatetraenoic acid (20-HETE) is formed by the omega-hydroxylation of arachidonic acid by cytochrome P450 4A and 4F enzymes, and it induces angio... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenic",
"start": 315,
"end": 325
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 2056,
"end": 2068
... | [] |
Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Hyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hypericum perforatum), has emerged as key player not only in the antidepressant activity of... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 134,
"end": 146
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 1130,
"end": 1142... | [] |
New vectors and strategies for cardiovascular gene therapy.
Cardiovascular diseases are the major cause of morbidity and mortality in both men and women in industrially developed countries. These disorders may result from impaired angiogenesis, particularly in response to hypoxia. Despite many limitations, gene therap... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 232,
"end": 244
},
"arguments": []
},
{
"trigger": {
"text": "revascularization",
"start": 419,
"end": ... | [] |
Impaired apoptosis of pulmonary endothelial cells is associated with intimal proliferation and irreversibility of pulmonary hypertension in congenital heart disease.
OBJECTIVES: This study sought to assess the cellular and histologic basis of irreversible pulmonary hypertension (PHT) in the clinical setting of congeni... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 718,
"end": 730
},
"arguments": []
},
{
"trigger": {
"text": "neoangiogenesis",
"start": 1106,
"end": 1... | [] |
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.
Vascular development is dependent on various growth factors and certain modifiers critical for providing arterial or venous identity, interaction with the surrounding stroma and tissues, hierarchic net... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interaction",
"start": 253,
"end": 264
},
"arguments": [
{
"role": "Theme",
"text": "stroma",
"start": 286,
"end": 292
},
... | [] |
An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody.
Platelet-derived growth factor (PDGF) and its receptors (PDGFR) play important roles in tumorigenesis through stimulating tumor growth and promoting angiogenesis via enhancing ... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binds",
"start": 449,
"end": 454
},
"arguments": [
{
"role": "Theme",
"text": "1B3",
"start": 445,
"end": 448
},
{
... | [] |
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.
Frequent coffee consumption has been associated with a reduced risk of colorectal cancer in a number of case-control studies. Coffee... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 496,
"end": 508
},
"arguments": [
{
"role": "AtLoc",
"text": "tumor",
"start": 490,
"end": 495
... | [] |
Medical therapy for intermittent claudication.
Medical therapy to improve symptoms, stabilise the underlying vascular disease and improve lower limb outcomes is an important and effective adjunct to lifestyle modification and surgical or endovascular interventions in patients with IC. Randomised placebo controlled tri... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 939,
"end": 951
},
"arguments": []
},
{
"trigger": {
"text": "collateralisation",
"start": 996,
"end": ... | [] |
An assay to measure angiogenesis in human fat tissue.
BACKGROUND: Inhibition of angiogenesis reverses rodent obesity. A validated assay in human fat tissue is needed to study the role of angiogenesis in human obesity. METHODS: Human fat tissue fragments from surgery were placed in 96-well plates, embedded in fibrin th... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 20,
"end": 32
},
"arguments": [
{
"role": "AtLoc",
"text": "fat tissue",
"start": 42,
"end": 52... | [] |
Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion.
The role of the pro-inflammatory peptide, LL-37, and its pro-form, human cationic antimicrobial protein 18 (hCAP-18), in cancer development and progression is poorly understo... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenic",
"start": 410,
"end": 420
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 1589,
"end": 1601
... | [] |
Role of telomeres in vascular senescence.
Telomeres are DNA regions composed of TTAGGG repeats that are located at the ends of chromosomes. Specific proteins associate with the telomeres and form non-nucleosomal DNA-protein complexes that serve as protective caps for the chromosome ends. There is accumulating evidence... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neovascularization",
"start": 740,
"end": 758
},
"arguments": []
}
],
"Breakdown": [
{
"trigger": {
"text": "dysfunction",
"start... | [] |
Tumor microenvironment, a dangerous society leading to cancer metastasis. From mechanisms to therapy and prevention.
Cancer is no longer considered by scientists just a jumble of mutated cells. To grow, invade and metastasize, a treacherous society between cancer and host cells must be formed, and this association pro... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interactions",
"start": 494,
"end": 506
},
"arguments": [
{
"role": "Theme",
"text": "host",
"start": 478,
"end": 482
},
... | [] |
[Photodynamic therapy in severe chronic central serous chorioretinopaty]
OBJECTIVE: To determine the efficacy of Photodynamic Therapy (PDT) in chronic Central Serous Chorioretinopathy (CSC). METHODS: Patients diagnosed with chronic CSC, with clinical evidence of activity and treated with Photodynamic Therapy, are incl... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neovascularization",
"start": 1082,
"end": 1100
},
"arguments": []
}
],
"Planned_process": [
{
"trigger": {
"text": "treated",
"s... | [] |
Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.
Vascular endothelial growth factor (VEGF) and Angiopoietin 1 (Ang1) are both potent proangiogenic factors, but, whereas VEGF causes vascular permeability, Ang1 stabilizes blood vessels and protects them from VEGF-induced pl... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "association",
"start": 833,
"end": 844
},
"arguments": [
{
"role": "Theme",
"text": "mDia",
"start": 848,
"end": 852
},
... | [] |
Suppression of lung tumor growth and metastasis in mice by adeno-associated virus-mediated expression of vasostatin.
PURPOSE: Angiogenesis inhibitors have strong therapeutic potential as antitumor agents in suppressing tumor growth and metastatic progression. Vasostatin, the N-terminal domain of calreticulin, is a pot... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "Angiogenesis",
"start": 127,
"end": 139
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 324,
"end": 336
... | [] |
Radiation retinopathy is treatable with anti-vascular endothelial growth factor bevacizumab (Avastin).
PURPOSE: To report on bevacizumab treatment for radiation retinopathy affecting the macula. PATIENTS AND METHODS: Twenty-one patients with radiation retinopathy (edema, hemorrhages, capillary dropout, and neovascular... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "neovascularization",
"start": 309,
"end": 327
},
"arguments": []
}
],
"Breakdown": [
{
"trigger": {
"text": "damage",
"start": 14... | [] |
Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma.
We hypothesized that signaling through multiple mitogen-activated protein kinase (MAPK) kinase (MKK) pathways is essential for the growth and vascularization of soft-tissue sarcomas, which are malignant tumors derive... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "vascularization",
"start": 70,
"end": 85
},
"arguments": [
{
"role": "AtLoc",
"text": "fibrosarcoma",
"start": 89,
"end... | [] |
Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells.
Physiological angiogenesis is regulated by various factors, including signaling through vascular endothelial growth factor (VEGF) receptors. We previously reported that a single dose of ethanol (1.4 g/kg), yielding a blood alcohol conce... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 98,
"end": 110
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 365,
"end": 377
... | [] |
Adenomatoid tumour of the liver.
An unusual primary adenomatoid tumour arising in the normal liver is described. Hepatectomy was performed, and the patient is alive and free of disease 1 year postsurgery. Grossly, the tumour showed a haemorrhagic cut surface with numerous microcystic structures. Histological examinati... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiomatoid",
"start": 342,
"end": 353
},
"arguments": []
}
],
"Cell_proliferation": [
{
"trigger": {
"text": "proliferation",
"s... | [] |
Research advances of endostatin and its short internal fragments.
Endostatin, the C-terminal fragment of collagen XVIII, is a potent angiogenesis inhibitor. At present, there are a large number of research papers on endostatin. However, the action mechanism of endostatin is still a matter of ongoing discussion. The ob... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 134,
"end": 146
},
"arguments": []
},
{
"trigger": {
"text": "angiogenic",
"start": 549,
"end": 559
... | [] |
Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists.
The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the A... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "revascularization",
"start": 740,
"end": 757
},
"arguments": [
{
"role": "AtLoc",
"text": "pulpal",
"start": 733,
"end"... | [] |
The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior.
Platelet-derived endothelial cell growth-factor (PD-ECGF) is similar to the pyrimidine enzyme thymidine phosphorylase (TP). A high TP expression at tumor sites is correlated with tumor growth, induction of angiogenes... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 310,
"end": 322
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 721,
"end": 733
... | [] |
Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia.
Bone marrow-derived mesenchymal stem cells (BM-MSC) have been demonstrated to be an attractive therapeutic cell source for tissue regeneration and repair. However, it remains unk... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 90,
"end": 102
},
"arguments": []
}
],
"Cell_proliferation": [
{
"trigger": {
"text": "proliferation",
"s... | [] |
Intracerebral grafting of cultured autologous skin fibroblasts into the rat striatum: an assessment of graft size and ultrastructure.
To identify a suitable donor cell population for gene therapy applications to the central nervous system, primary fibroblasts isolated from skin biopsies and maintained in culture are e... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "contact",
"start": 561,
"end": 568
},
"arguments": [
{
"role": "Theme",
"text": "cells",
"start": 546,
"end": 551
}
]
... | [] |
Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity.
OBJECTIVE: The expansion of adipose tissue is linked to the development of its vasculature. However, the regulation of adipose tissue angiogenesis in humans has not been extensively studied. Our aim was to compare the angiog... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "connection",
"start": 1050,
"end": 1060
},
"arguments": [
{
"role": "Theme",
"text": "CAM",
"start": 1069,
"end": 1072
},
... | [] |
M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo.
BACKGROUND: M-CSF recruits mononuclear phagocytes which regulate processes such as angiogenesis and metastases in tumors. VEGF is a potent activator of angiogenesis as it promotes endothelial cell proliferati... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "binding",
"start": 703,
"end": 710
},
"arguments": [
{
"role": "Theme2",
"text": "HIF",
"start": 699,
"end": 702
},
... | [] |
A novel integrin alpha5beta1 antagonistic peptide, A5-1, screened by Protein Chip system as a potent angiogenesis inhibitor.
Integrin alpha5beta1 immobilized on a ProteoChip was used to screen new antagonistic peptides from multiple hexapeptide sub-libraries of the positional scanning synthetic peptide combinatorial l... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interaction",
"start": 375,
"end": 386
},
"arguments": [
{
"role": "Theme",
"text": "integrin alpha5beta1",
"start": 342,
"end": 362
... | [] |
Evaluation of electrical stimulation for ischemic wound therapy: a feasibility study using the lapine wound model.
Chronic wounds are a major secondary complication for many people with impaired mobility. Electrical stimulation (ES) has been recommended as a adjunctive therapy, however optimal treatment paradigms have... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1795,
"end": 1807
},
"arguments": []
}
],
"Gene_expression": [
{
"trigger": {
"text": "expression",
"star... | [] |
VEGF, angiopoietin-1 and -2 in bronchial asthma: new molecular targets in airway angiogenesis and microvascular remodeling.
Airway angiogenesis and microvascular remodeling are known features of bronchial asthma, but the mechanisms of these structural alterations are just beginning to be elucidated. Vascular endotheli... | {
"json_structures": {
"Binding": [
{
"trigger": {
"text": "interactions",
"start": 1265,
"end": 1277
},
"arguments": [
{
"role": "Theme",
"text": "VEGF",
"start": 1286,
"end": 1290
},
... | [] |
Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction.
BACKGROUND: Mesenchymal stem cells (MSCs) transplantation is of therapeutic potential after ischemic injury in both experimental and clinical studies. Clinically, elderly pa... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 2556,
"end": 2568
},
"arguments": []
}
],
"Cell_proliferation": [
{
"trigger": {
"text": "proliferated",
... | [] |
Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer.
Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) plays an essential role in angiogenesis and development. A previous study showed that the expression of COUP-TFII enhanced ... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 224,
"end": 236
},
"arguments": []
}
],
"Gene_expression": [
{
"trigger": {
"text": "expression",
"start"... | [] |
Involvement of PTEN promoter methylation in cerebral cavernous malformations.
BACKGROUND AND PURPOSE: Cerebral cavernous malformations (CCMs) are prevalent cerebral vascular lesions involving aberrant angiogenesis. However, the underlying mechanism is poorly understood. Phosphatase and tension homolog deleted on chrom... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 202,
"end": 214
},
"arguments": []
},
{
"trigger": {
"text": "angiogenesis",
"start": 545,
"end": 557
... | [] |
Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors.
BACKGROUND: Aberrant angiogenesis is a landmark feature in cancer, which is important for proliferation, growth and metastasis, and is mediated by various pro-angiogenic factors. The VEGF pathway i... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 69,
"end": 81
},
"arguments": [
{
"role": "AtLoc",
"text": "tumour",
"start": 62,
"end": 68
... | [] |
The effect of perfluorocarbon-based artificial oxygen carriers on tissue-engineered trachea.
The biological effect of the perfluorocarbon-based artificial oxygen carrier (Oxygent) was investigated in tissue-engineered trachea (TET) construction. Media supplemented with and without 10% Oxygent were compared in all asse... | {
"json_structures": {
"Blood_vessel_development": [
{
"trigger": {
"text": "angiogenesis",
"start": 1768,
"end": 1780
},
"arguments": []
}
],
"Development": [
{
"trigger": {
"text": "formation",
"start": 1... | [] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.